fz

Summary

Gene Symbol: fz
Description: frizzled
Alias: CG17697, CG3646, DFZ1, DFz, DFz1, Dfz, Dfz1, Dm Fz1, Dmel\CG17697, Frz, Fz1, dFz, frz, fz1, fz[[1]], CG17697 gene product from transcript CG17697-RA, CG17697-PA, CG17697-PC, Frizzled1, frizzled 1, frizzled[[1]], fz-PA, fz-PC
Species: fruit fly

Top Publications

  1. pmc Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 12:2610-22. 1998
  2. pmc Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics, and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Dev Cell 20:511-25. 2011
  3. pmc The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis
    Rebecca Bastock
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 134:3055-64. 2007
  4. pmc Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling
    Andreas Jenny
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cellular and Developmental Biology, 1 Gustave L Levy Place, New York, NY 10029, USA
    EMBO J 22:4409-20. 2003
  5. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
  6. pmc Differential stability of flamingo protein complexes underlies the establishment of planar polarity
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics and, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN Sheffield, United Kingdom
    Curr Biol 18:1555-64. 2008
  7. pmc The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation
    Jie Yan
    Biology Department, Department of Cell Biology, Morphogenesis and Regenerative Medicine Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 180:219-28. 2008
  8. ncbi Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development
    P Bhanot
    Department of Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Development 126:4175-86. 1999
  9. ncbi The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family
    J Chae
    Department of Life Science, Kwangju Institute of Science and Technology K JIST, Kwangju, Korea
    Development 126:5421-9. 1999
  10. ncbi Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye
    Amy S Rawls
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 130:1877-87. 2003

Detail Information

Publications160 found, 100 shown here

  1. pmc Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 12:2610-22. 1998
    In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may utilize DFz2 as a receptor...
  2. pmc Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics, and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Dev Cell 20:511-25. 2011
    ..Thus, we define the distinct roles of specific core proteins in the formation of asymmetric contacts between cells, which is a key event in the generation of coordinated cellular asymmetry...
  3. pmc The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis
    Rebecca Bastock
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 134:3055-64. 2007
    ..We conclude that, during collective cell migration, the planar polarity pathway can mediate communication between motile and non-motile cells, which enhances the efficiency of migration via the modulation of actin dynamics...
  4. pmc Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling
    Andreas Jenny
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cellular and Developmental Biology, 1 Gustave L Levy Place, New York, NY 10029, USA
    EMBO J 22:4409-20. 2003
    Frizzled (Fz) signaling regulates the establishment of planar cell polarity (PCP). The PCP genes prickle (pk) and strabismus (stbm) are thought to antagonize Fz signaling...
  5. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
    ..Thus, while our results support the existence of Ft-Ds binding and show that it is sufficient to alter PCP, ds expression is permissive or redundant with other PCP cues in much of the wing...
  6. pmc Differential stability of flamingo protein complexes underlies the establishment of planar polarity
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics and, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN Sheffield, United Kingdom
    Curr Biol 18:1555-64. 2008
    ..The core polarity protein Flamingo (Fmi) localizes to both proximal and distal cell boundaries and is known to have asymmetric activity, but the molecular basis of this asymmetric activity is unknown...
  7. pmc The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation
    Jie Yan
    Biology Department, Department of Cell Biology, Morphogenesis and Regenerative Medicine Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 180:219-28. 2008
    ..This later function appears to be a feedback mechanism that limits cytoskeleton activation to ensure a single hair is formed...
  8. ncbi Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development
    P Bhanot
    Department of Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Development 126:4175-86. 1999
    ..The redundancy of Frizzled and Dfrizzled2 explains why Wingless receptors were not identified in earlier genetic screens for mutants defective in embryonic patterning...
  9. ncbi The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family
    J Chae
    Department of Life Science, Kwangju Institute of Science and Technology K JIST, Kwangju, Korea
    Development 126:5421-9. 1999
    ..The detailed polarity phenotype of stan on the wing suggested that it is most likely a component of the frizzled (fz) pathway. Consistent with this hypothesis, stan appears to be downstream of and required for fz function...
  10. ncbi Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye
    Amy S Rawls
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 130:1877-87. 2003
    ..Our data suggest that Strabismus, Flamingo and Prickle function together to regulate the establishment of tissue polarity in the Drosophila eye...
  11. pmc The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling
    Jun Wu
    Mount Sinai School of Medicine, Department of Developmental and Regenerative Biology, 1 Gustav L Levy Place, New York, NY 10029, USA
    Dev Cell 15:462-9. 2008
    The Frizzled (Fz) receptor is required cell autonomously in Wnt/beta-catenin and planar cell polarity (PCP) signaling...
  12. ncbi Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
    Nicholas S Tolwinski
    Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 4:407-18. 2003
    ..We propose that Arrow (LRP) recruits Axin to the membrane, and that this interaction leads to Axin degradation. As a consequence, Armadillo is no longer bound by Axin, resulting in nuclear signaling by Armadillo...
  13. ncbi Smoothened translates Hedgehog levels into distinct responses
    Joan E Hooper
    Department of Cell and Structural Biology and Program in Cell and Developmental Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Development 130:3951-63. 2003
    ..Thus, two activities of Smoothened translate different levels of Hedgehog into distinct intracellular responses...
  14. ncbi Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
    ..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy...
  15. ncbi Wnt-mediated axon guidance via the Drosophila Derailed receptor
    Shingo Yoshikawa
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, PO Box 85800, San Diego, California 92186, USA
    Nature 422:583-8. 2003
    ..Our results reveal an unexpected role in axon guidance for a Wnt family member, and show that the Derailed receptor is an essential component of Wnt signalling in these guidance events...
  16. ncbi frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis
    K M Bhat
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cell 95:1027-36. 1998
    The Drosophila Frizzled (Fz) and Frizzled2 (DFz2) proteins function as receptors for Wingless (Wg) in tissue culture cells...
  17. ncbi Transducing properties of Drosophila Frizzled proteins
    W R Strapps
    Department of Genetics and Development, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 701 West 168 Street, Room 602, New York, NY 10032, USA
    Development 128:4829-35. 2001
    In Drosophila, two closely related serpentine receptors, Frizzled (Fz) and D-Frizzled2 (Fz2) are able to act as receptors for the secreted Wnt peptide, Wingless (Wg)...
  18. ncbi Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
    David R P Tree
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
    Cell 109:371-81. 2002
    ..This activity is linked to Frizzled activity on the adjacent cell surface. Prickle therefore functions in a feedback loop that amplifies differences between Frizzled levels on adjacent cell surfaces...
  19. ncbi Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway
    Anne Kathrin Classen
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01309 Dresden, Germany
    Dev Cell 9:805-17. 2005
    ..We propose that these proteins polarize trafficking of Cadherin-containing exocyst vesicles during junction remodeling. This may be a common mechanism for the action of planar cell polarity proteins in diverse systems...
  20. pmc Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila
    Jun Wu
    Developmental and Regenerative Biology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mech Dev 125:30-42. 2008
    Members of the Frizzled (Fz) family of seven-pass transmembrane receptors are required for the transduction of both Wnt-Fz/beta-catenin and Fz/planar cell polarity (PCP) signals...
  21. ncbi Signaling specificity by Frizzled receptors in Drosophila
    M Boutros
    European Molecular Biology Laboratory, Developmental Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Science 288:1825-8. 2000
    Wnt-Frizzled (Fz) signaling pathways play recurring important roles during the development and homeostasis of vertebrates and invertebrates. Fz receptors can signal through beta-catenin-dependent and -independent pathways...
  22. ncbi Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels
    P N Adler
    Biology Department, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 7:940-9. 1997
    The frizzled (fz) gene of Drosophila encodes the founding member of the large family of receptors for the Wnt family of signaling molecules...
  23. pmc Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling
    J D Axelrod
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Genes Dev 15:1182-7. 2001
    Drosophila epithelia acquire a planar cell polarity (PCP) orthogonal to their apical-basal axes. Frizzled (Fz) is the receptor for the PCP signal, and Dishevelled (Dsh) transduces the signal...
  24. ncbi Fidelity in planar cell polarity signalling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 421:543-7. 2003
    ..Subsequent action of the Frizzled feedback loop is sufficient to align all the cells cooperatively. This economical system is therefore highly robust, and produces virtually error-free arrays...
  25. ncbi Cooperative activities of drosophila DE-cadherin and DN-cadherin regulate the cell motility process of ommatidial rotation
    Ivana Mirkovic
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY, USA
    Development 133:3283-93. 2006
    ..A similar input into mammalian E- and N-cadherins might function in the progression of diseases such as metastatic ovarian cancer...
  26. pmc Differential activities of the core planar polarity proteins during Drosophila wing patterning
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK
    Dev Biol 302:181-94. 2007
    ....
  27. ncbi The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization
    F Feiguin
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Dev Cell 1:93-101. 2001
    ..Our data suggest that Frizzled acts through Diego to promote local clustering of Flamingo, and that clustering of Diego and Flamingo in one cell nonautonomously propagates to others...
  28. pmc Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling
    Wei Shen Chen
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 133:1093-105. 2008
    ..The transmembrane proteins Frizzled (Fz) and Van Gogh (Vang) are essential components of the intercellular communication mechanism, as loss of either ..
  29. ncbi Planar polarity: out of joint?
    S Bray
    Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, UK
    Curr Biol 10:R155-8. 2000
    ..This planar polarity requires the transmembrane receptor Frizzled. Recent studies have shed new light on mechanisms that could be involved in generating or transducing the polarity signal...
  30. ncbi Wolbachia bacteria, the cause for false vesicular staining pattern in Drosophila melanogaster
    Kyung Ok Cho
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene Expr Patterns 5:167-70. 2004
    ..Thus, combinatorial use of contaminated antisera and Wolbachia-infected flies can result in serious misinterpretations, which can be avoided by curing laboratory strains of Wolbachia...
  31. pmc Cell packing influences planar cell polarity signaling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 105:18800-5. 2008
    ..Hence, in the wild type, broad distribution of the global directional cue combines with a local feedback mechanism to overcome irregularities in cell packing geometry during PCP signaling...
  32. ncbi Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
    T Usui
    Department of Biophysics, Faculty of Science, Japan
    Cell 98:585-95. 1999
    ..This biased localization of Fmi appears to be driven by an imbalance of the activity of Frizzled (Fz) across the proximal/distal cell boundary...
  33. ncbi Frizzled signaling and cell-cell interactions in planar polarity
    P N Adler
    Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Opin Cell Biol 13:635-40. 2001
    ..This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair...
  34. ncbi Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila
    C R Vinson
    Biology Department, University of Virginia, Charlottesville 22901
    Nature 329:549-51. 1987
    The function of the frizzled (fz) locus is required for the development of a parallel array of bristles and hairs on the adult cuticle of Drosophila melanogaster...
  35. pmc Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
    L L Wong
    Biology Department, University of Virginia, Charlottesville 22901
    J Cell Biol 123:209-21. 1993
    ..This suggests that the tissue polarity genes function in or on a pathway that controls hair polarity by regulating the subcellular location for prehair formation...
  36. ncbi Dishevelled is a component of the frizzled signaling pathway in Drosophila
    R E Krasnow
    Biology Department, University of Virginia, Charlottesville 22903, USA
    Development 121:4095-102. 1995
    ..Three of the genes, frizzled (fz), dishevelled (dsh), and prickle (pk) share a similar tissue polarity phenotype, suggesting that they function ..
  37. ncbi A new member of the frizzled family from Drosophila functions as a Wingless receptor
    P Bhanot
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 382:225-30. 1996
    ..Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules...
  38. ncbi Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling
    P N Adler
    Biology Department, University of Virginia, Charlottesville, VA 22903, USA
    Development 125:959-68. 1998
    ..The direction of this domineering nonautonomy was coincident with the direction of the abnormal hair polarity. We conclude that dachsous causes a tissue polarity phenotype because it alters the direction of frizzled signaling...
  39. ncbi Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis
    M Wehrli
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 125:1421-32. 1998
    ..Further, we show that the polarizing information acting in this equatorial/polar axis (Eq/Pl) is established in at least two steps - the activity of one signaling molecule functions to establish the graded activity of a second signal...
  40. ncbi Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila
    M Gho
    Laboratoire de Génétique du Développement de la Drosophile, URA 1857, Ecole Normale Superieure, Paris, France
    Nature 393:178-81. 1998
    ..This difference in cell-division orientation is largely independent of the identity of the secondary precursor cells, and is regulated by Frizzled-independent mechanisms...
  41. ncbi Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
    J R Kennerdell
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Cell 95:1017-26. 1998
    ..Our results demonstrate that dsRNA interference can be used to analyze many aspects of gene function...
  42. pmc The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs
    D Gubb
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Genes Dev 13:2315-27. 1999
    ..Lack of both pk and sple transcripts gives a phenotype affecting the whole body surface that is similar to those of dishevelled and frizzled (fz) suggesting a functional relationship between pk and fz signaling.
  43. ncbi Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila
    B Lu
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, California 94143 0725, USA
    Curr Biol 9:1247-50. 1999
    ..Instead, the Frizzled (Fz) protein mediates a planar polarity signal that controls the anteroposteriorly oriented first division (pl) of SOPs [..
  44. ncbi Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye
    U Weber
    European Molecular Biology Laboratory, Developmental Biology Programme, Meyerhofstrasse 1, Germany
    Development 127:3619-29. 2000
    ..Genetic interaction studies have suggested that Jun and JNK signaling are involved in Frizzled (Fz)-mediated planar polarity generation in the Drosophila eye...
  45. ncbi The domineering non-autonomy of frizzled and van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling
    P N Adler
    Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
    Mech Dev 96:197-207. 2000
    The frizzled (fz) gene is required for the development of distally pointing hairs on the Drosophila wing. It has been suggested that fz is needed for the propagation of a signal along the proximal distal axis of the wing...
  46. ncbi Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
    C G Winter
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 105:81-91. 2001
    Frizzled (Fz) and Dishevelled (Dsh) are components of an evolutionarily conserved signaling pathway that regulates planar cell polarity...
  47. ncbi Regulated endocytic routing modulates wingless signaling in Drosophila embryos
    L Dubois
    National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, United Kingdom
    Cell 105:613-24. 2001
    ....
  48. ncbi Asymmetric colocalization of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarization
    Y Shimada
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, 606 8502, Kyoto, Japan
    Curr Biol 11:859-63. 2001
    ..Achievement of the biased Fmi pattern depends on two upstream components in the PCP signaling pathway: Frizzled (Fz), a receptor for a hypothetical polarity signal, and an intracellular protein, Dishevelled (Dsh) [6-8]...
  49. ncbi Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A
    Michael Hannus
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 129:3493-503. 2002
    ..In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms...
  50. ncbi Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning
    Rebecca Bastock
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 130:3007-14. 2003
    ..In the second phase, Dishevelled and Prickle are required for these proteins to become asymmetrically distributed on the proximodistal axis...
  51. ncbi The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila
    Yohanns Bellaiche
    Ecole Normale Superieure, UMR 8542, 46, rue d Ulm, 75230 Paris, Cedex 05, France
    Development 131:469-78. 2004
    ..bristle lineage, the sensory organ precursor (pI) cell is polarized along the anteroposterior (AP) axis by Frizzled (Fz) receptor signaling...
  52. ncbi Cell interactions and planar polarity in the abdominal epidermis of Drosophila
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 131:4651-64. 2004
    ..We study four polarity genes, frizzled (fz), prickle (pk), Van gogh/strabismus (Vang/stbm) and starry night/flamingo (stan/fmi), and note what happens when ..
  53. ncbi Trimeric G protein-dependent frizzled signaling in Drosophila
    Vladimir L Katanaev
    Department of Genetics and Development, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 701 West 168 Street, New York, NY 10032, USA
    Cell 120:111-22. 2005
    Frizzled (Fz) proteins are serpentine receptors that transduce critical cellular signals during development. Serpentine receptors usually signal to downstream effectors through an associated trimeric G protein complex...
  54. ncbi The endocytic pathway and formation of the Wingless morphogen gradient
    Eric Marois
    Max Planck Institute for Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Development 133:307-17. 2006
    ..Thus, subcellular localization of Wingless along the apical-basal axis of receiving cells may be instrumental in shaping the Wingless gradient...
  55. ncbi frizzled regulates mirror-symmetric pattern formation in the Drosophila eye
    L Zheng
    Department of Biological Sciences, University of Pittsburgh, PA 15260, USA
    Development 121:3045-55. 1995
    ..We propose that frizzled mediates a bidirectional signal emanating from the equator...
  56. ncbi The frizzled gene of Drosophila encodes a membrane protein with an odd number of transmembrane domains
    W J Park
    Biology Department, University of Virginia, Charlottesville 22901
    Mech Dev 45:127-37. 1994
    The protein encoded by the Drosophila tissue polarity gene, frizzled (fz), is required for both the intercellular transmission and the intracellular transduction of a tissue polarity signal...
  57. pmc Molecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster
    K H Jones
    Biology Department, University of Virginia, Charlottesville 22903, USA
    Genetics 142:205-15. 1996
    The frizzled (fz) gene of Drosophila is essential for the development of normal tissue polarity in the adult cuticle of Drosophila. In fz mutants the parallel array of hairs and bristles that decorate the cuticle is disrupted...
  58. ncbi Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
    M Boutros
    European Molecular Biology Laboratory, Developmental Biology Programme, Heidelberg, Germany
    Cell 94:109-18. 1998
    ..Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain ..
  59. ncbi Identification and characterization of a novel line of Drosophila Schneider S2 cells that respond to wingless signaling
    S Yanagawa
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 273:32353-9. 1998
    ..S2R+ cells are as sensitive to Wg as are clone 8 cells but can grow in simpler medium. Therefore, the S2R+ cell line is likely to prove highly useful for in vitro analyses of Wg signaling...
  60. ncbi A role for Wnts in morpho-genesis and tissue polarity
    S Sokol
    Nat Cell Biol 2:E124-5. 2000
    ..The analysis of Dishevelled, a cytoplasmic mediator of Wnt signalling, reveals unexpected similarity between gastrulation in vertebrates and polarization of cells in Drosophila epithelia...
  61. ncbi Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division
    Y Bellaiche
    Ecole Normale Superieure, UMR 8544, 46, rue d Ulm, 75230 Paris Cedex 05, France
    Nat Cell Biol 3:50-7. 2001
    ..By imaging living frizzled (fz) mutant pupae we show that Fz regulates the orientation of the polarity axis of pI, the initiation of spindle ..
  62. ncbi Asymmetric cell division: plane but not simple
    P N Adler
    University of Virginia, Department of Biology and Cancer Center, Charlottesville, Virginia 22903, USA
    Curr Biol 11:R233-6. 2001
    ..The orientation of these divisions is under the control of the Frizzled pathway that generates planar polarity in a number of cell types...
  63. ncbi The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila
    Y Bellaiche
    Ecole Normale Superieure, UMR 8544, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Cell 106:355-66. 2001
    Frizzled (Fz) signaling regulates cell polarity in both vertebrates and invertebrates. In Drosophila, Fz orients the asymmetric division of the sensory organ precursor cell (pI) along the antero-posterior axis of the notum...
  64. ncbi Planar polarity: photoreceptors on a high fat diet
    Helen Strutt
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 12:R384-5. 2002
    ..Differential activity of Frizzled in the R3/R4 photo-receptors of Drosophila regulates the orientation of ommatidia. New evidence suggests that the cadherins Dachsous and Fat act upstream of Frizzled in this process...
  65. ncbi Long-range coordination of planar polarity in Drosophila
    Helen Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Bioessays 27:1218-27. 2005
    ..Subsequently, this long-range polarity signal is refined by local cell-cell interactions involving the transmembrane molecules Frizzled, Strabismus and Flamingo. The role of these factors in coordinating polarity will be discussed...
  66. ncbi Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila
    Helen Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Curr Biol 16:1329-36. 2006
    ..Finally, we also find that dco function in polarity is partially redundant with CKIalpha...
  67. ncbi Multiple roles of a trimeric G protein in Drosophila cell polarization
    Vladimir L Katanaev
    Department of Biology, University of Konstanz, Konstanz, Germany
    Cell Cycle 5:2464-72. 2006
    ..In Drosophila PCP is under the hierarchical control of Frizzled (Fz)-a serpentine receptor (that also functions in the Wnt signaling pathway)...
  68. doi The Frizzled Planar Cell Polarity signaling pathway controls Drosophila wing topography
    Kristy Doyle
    Department of Biological Sciences, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA
    Dev Biol 317:354-67. 2008
    ..Each wing epithelial cell produces a distally pointing hair under the control of the Frizzled (Fz) PCP signaling pathway...
  69. pmc Wnt/PCP proteins regulate stereotyped axon branch extension in Drosophila
    Julian Ng
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, United Kingdom
    Development 139:165-77. 2012
    ..I found that Wnt/PCP components do not need to be asymmetrically localized to distinct branches to execute branching functions. However, Prickle axonal localization depends on Frizzled and Strabismus...
  70. pmc Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity
    Gary Struhl
    Department of Genetics and Development, HHMI, HHSC, College of Physicians and Surgeons, 701 West 168th Street, Room 1116, New York, NY 10032, USA
    Development 139:3665-74. 2012
    ..Stan acts together with other transmembrane proteins, most notably Frizzled (Fz) and Van Gogh (Vang, also called Strabismus)...
  71. ncbi The genetic control of tissue polarity in Drosophila
    P N Adler
    Biology Department, University of Virginia, Charlottesville
    Bioessays 14:735-41. 1992
    ..Based on their behavior in genetic mosaics, it has proved possible to determine that individual genes are required either for the generation of an intercellular polarity signal and/or the transduction of that signal to the cytoskeleton...
  72. ncbi A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains
    C R Vinson
    Biology Department, University of Virginia, Charlottesville 22901
    Nature 338:263-4. 1989
    The function of the frizzled (fz) locus in Drosophilia melanogaster is required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles (for example on the wild-type wing all hairs ..
  73. ncbi A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster
    D Gubb
    J Embryol Exp Morphol 68:37-57. 1982
    The polarity mutants pk, sple, mwh, fz and in alter the orientations of cuticular processes in several regions of the body. The mutant polarity patterns are constant and do not result from alterations in cell lineage...
  74. ncbi four-jointed is required for intermediate growth in the proximal-distal axis in Drosophila
    J L Villano
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038, USA
    Development 121:2767-77. 1995
    ..We propose that fj encodes a secreted signal that functions as a positive regulator of regional growth and differentiation along the PD axis of the imaginal discs...
  75. ncbi The cold-sensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis
    P N Adler
    Biology Department, University of Virginia, Charlottesville 22903 2477
    Mech Dev 46:101-7. 1994
    The function of the frizzled (fz) gene is essential for the development of the normal pattern of hairs on the Drosophila wing. In the absence of fz function hairs develop, but they display an abnormal polarity...
  76. ncbi Planar polarization of Drosophila and vertebrate epithelia
    S Eaton
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Curr Opin Cell Biol 9:860-6. 1997
    ..Advances in our understanding of the Frizzled pathway, which coordinates planar polarization in Drosophila, are moving the field closer to understanding the links between signal transduction and polarized cytoskeletal reorganization...
  77. pmc Van Gogh: a new Drosophila tissue polarity gene
    J Taylor
    Biology Department and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 150:199-210. 1998
    ..In both cases the domineering nonautonomy was suppressed consistent with Van Gogh being essential for frizzled signaling...
  78. ncbi Frizzled signaling and the developmental control of cell polarity
    J M Shulman
    Wellcome CRC Institute, UK
    Trends Genet 14:452-8. 1998
    ..However, the founding member of the Frizzled family, Drosophila Frizzled (FZ), was cloned almost a decade ago because of its role in regulating cell polarity within the plane of an epithelium...
  79. ncbi Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants
    A Sato
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 126:4421-30. 1999
    ..Wingless signaling may thus be attenuated by Dfrizzled-3 at least in wingless hypomorphic mutants...
  80. ncbi Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
    C M Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 126:5441-52. 1999
    ..Two members of the Frizzled (Fz) family of seven-pass transmembrane proteins, Drosophila Fz and Fz2, can bind Wg and are candidate Wg receptors...
  81. ncbi Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless
    E J Rulifson
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, California 94305, USA
    Mol Cell 6:117-26. 2000
    The Frizzled (Fz) protein in Drosophila is a bifunctional receptor that acts through a GTPase pathway in planar polarity signaling and as a receptor for Wingless (Wg) using the canonical Wnt pathway...
  82. ncbi Control of dendritic field formation in Drosophila: the roles of flamingo and competition between homologous neurons
    F B Gao
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143, USA
    Neuron 28:91-101. 2000
    ..Whereas Flamingo functions downstream of Frizzled in specifying planar polarity, Flamingo-dependent dendritic outgrowth is independent of Frizzled...
  83. ncbi Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing
    D I Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN, Sheffield, United Kingdom
    Mol Cell 7:367-75. 2001
    ..This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell...
  84. ncbi Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye
    Chung Hui Yang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 108:675-88. 2002
    ....
  85. ncbi DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis
    E David Cohen
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 2:437-48. 2002
    ..The DWnt4 cell motility pathway is distinct from both the canonical Wnt pathway and the planar polarity pathway. Our data suggest that DWnt4 facilitates motility through regulation of focal adhesions...
  86. pmc The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy
    Haeryun Lee
    Biology Department and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 160:1535-47. 2002
    ..g., abdomen) the inturned-like genes were epistatic to the frizzled-like genes, but in other body regions (e.g., eye) that was not the case. Thus, the genetic control of tissue polarity is body region specific...
  87. ncbi Planar polarity and actin dynamics in the epidermis of Drosophila
    Julia A Kaltschmidt
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Nat Cell Biol 4:937-44. 2002
    ..We show that Wingless (Wg) signalling and Jun amino-terminal kinase (JNK) signalling have overlapping but different roles in these events...
  88. ncbi Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled
    Helen Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, United Kingdom
    Dev Cell 3:851-63. 2002
    The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously...
  89. ncbi Frizzled signalling and cell polarisation in Drosophila and vertebrates
    David Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 130:4501-13. 2003
    ..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation...
  90. ncbi EGF signaling and ommatidial rotation in the Drosophila eye
    Helen Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Curr Biol 13:1451-7. 2003
    ..The choice of chirality is governed by higher activity of the frizzled (fz) gene in one cell of the R3/R4 photoreceptor pair and by Notch-Delta (N-Dl) signaling...
  91. pmc Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2
    Stacey K Ogden
    Department of Pharmacology and Toxicology, Dartmouth Medical School, 7650 Remsen Hall, Hanover, NH 03755, USA
    Curr Biol 13:1998-2003. 2003
    ..This work fills in the last major gap in our understanding of the Hh signal transduction pathway by suggesting that no intermediate signal is required to connect Smo to the HSC...
  92. ncbi Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors
    Mathias F Wernet
    New York University, Department of Biology, 100 Washington Square East, New York, NY 10003, USA
    Cell 115:267-79. 2003
    ..Homothorax expression is induced by the iroquois complex and the wingless (wg) pathway. However, crucial wg pathway components are not required, suggesting that additional signals are involved...
  93. ncbi Patterned gene expression directs bipolar planar polarity in Drosophila
    Jennifer A Zallen
    Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
    Dev Cell 6:343-55. 2004
    ..These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement...
  94. pmc Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless
    Chiann Mun Chen
    Howard Hughes Medical Institute and Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:15961-6. 2004
    ..Thus, we infer that signal transduction does not require binding of Wg to the CRD, but instead depends on interactions between Wg and other portions of the receptor, or other proteins of the receptor complex...
  95. ncbi Inturned localizes to the proximal side of wing cells under the instruction of upstream planar polarity proteins
    Paul N Adler
    Biology Department, Morphogenesis and Regenerative Medicine, Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 14:2046-51. 2004
    Planar polarity development in the Drosophila wing is under the control of the frizzled (fz) pathway...
  96. ncbi Temporal regulation of planar cell polarity: insights from the Drosophila eye
    Francois Schweisguth
    Cell 121:497-9. 2005
    ..The authors propose that a component of the apical Crumbs complex regulates the phosphorylation of the Frizzled (Fz) PCP receptor, thus modulating PCP in the Drosophila eye.
  97. ncbi The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye
    Alexandre Djiane
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 121:621-31. 2005
    ..While apical localization of PCP determinants such as Frizzled (Fz1) is critical for their function, the link between A/B polarity and PCP is poorly understood...
  98. ncbi Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding
    Andreas Jenny
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cellular and Developmental Biology, 1 Gustave L Levy Place, New York, NY 10029, USA
    Nat Cell Biol 7:691-7. 2005
    ..Strikingly, Diego and Prickle compete with one another for Dishevelled binding, thereby modulating Frizzled/Dishevelled activity and ensuring tight control over Frizzled PCP signalling...
  99. ncbi Control of planar cell polarity by interaction of DWnt4 and four-jointed
    Janghoo Lim
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genesis 42:150-61. 2005
    The Drosophila eye and the wing display specific planar cell polarity. Although Frizzled (Fz) signaling has been implicated in the establishment of ommatidial and wing hair polarity, evidence for the Wnt gene function has been limited...
  100. pmc Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism
    Michael Povelones
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genetics 171:1643-54. 2005
    The frizzled (fz) gene in Drosophila controls two distinct signaling pathways: it directs the planar cell polarization (PCP) of epithelia and it regulates cell fate decisions through Armadillo (Arm) by acting as a receptor for the Wnt ..
  101. pmc The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling
    Michael Povelones
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    EMBO J 24:3493-503. 2005
    The Frizzled (Fz) receptors contain seven transmembrane helices and an amino-terminal cysteine-rich domain (CRD) that is sufficient and necessary for binding of the ligands, the Wnts...

Research Grants17

  1. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  2. Mechanisms governing polarity in Drosophila oogenesis
    Daniel Kalderon; Fiscal Year: 2004
    ....
  3. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  4. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  5. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..Insights into new diagnostic markers and novel therapeutic targets and approaches for cancer are also expected. ..
  6. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  7. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  8. Mechanism of Hedgehog signal transduction
    JOAN HOOPER; Fiscal Year: 2007
    ..Their successful completion would significantly advance our understanding of this fundamental signal transduction pathway and may pinpoint therapeutic targets for Hh-based pathologies. [unreadable] [unreadable] [unreadable]..
  9. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..
  11. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  12. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
    ..Since the machinery for Wnt signal transduction is also evolutionarily conserved, understanding tissue specific mechanisms of Wg signaling in flies should have broad relevance to other organisms. ..
  13. ANALYSIS OF NEUROFIBROMATOSIS TYPE 1 GENE FUNCTION
    Andre Bernards; Fiscal Year: 2003
    ..These studies will help us understand the normal function of the NF1 gene in vivo and will contribute to our understanding of the diverse manifestations of the disease process. ..
  14. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  15. GENETIC CONTROL OF CELL FATE DIVERSITY IN DROSOPHILA
    Amy Bejsovec; Fiscal Year: 2003
    ..This specificity may indicate a novel function in the Wg pathway. Aim 4 describes a plan for the molecular cloning of this new gene and for the subsequent characterization of its gene product. ..
  16. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  17. Conference on Wnt and Beta Catenin Signaling
    Randall Moon; Fiscal Year: 2002
    ..Given the explosive growth in research in this field owing to its connection to various cancers, it is extremely timely to have a meeting with the joint focus on the roles of Wnt and B-catenin signaling in both development and disease. ..