hth

Summary

Gene Symbol: hth
Description: homothorax
Alias: 1323/07, 1422/04, CG17117, Dm-HTH, Dmel\CG17117, HTH, Hth, Meis1, P53, anon-EST:Liang-2.13, clone 2.13, dtl, hth1, hth2, l(3)05745, l(3)86Ca, CG17117 gene product from transcript CG17117-RC, CG17117-PA, CG17117-PC, CG17117-PE, CG17117-PF, CG17117-PI, dorsotonals, gene II, hth-PA, hth-PC, hth-PE, hth-PF, hth-PI
Species: fruit fly

Top Publications

  1. doi hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit
    Carla S Lopes
    CABD Centro Andaluz de Biologia del Desarrollo Univ Pablo de Olavide CSIC, Ctra Utrera km 1, Sevilla 41013, Spain
    Dev Biol 339:78-88. 2010
  2. ncbi Specificity of Distalless repression and limb primordia development by abdominal Hox proteins
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Dev Cell 3:487-98. 2002
  3. pmc Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
    H Wayne Peng
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 23:2307-19. 2009
  4. pmc Genome-wide tissue-specific occupancy of the Hox protein Ultrabithorax and Hox cofactor Homothorax in Drosophila
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e14686. 2011
  5. doi Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system
    Ramakrishnan Kannan
    Center for Cellular and Molecular Biology, Hyderabad, India
    Mech Dev 127:137-45. 2010
  6. ncbi Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex
    Ulrich Weihe
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:767-74. 2004
  7. ncbi Cofactor-interaction motifs and the cooption of a homeotic Hox protein into the segmentation pathway of Drosophila melanogaster
    Ulrike Löhr
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Gottingen, Germany
    Curr Biol 15:643-9. 2005
  8. pmc Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 135:627-36. 2008
  9. pmc Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in Drosophila
    Siew Woh Choo
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e14778. 2011
  10. ncbi Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
    G E Rieckhof
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 91:171-83. 1997

Research Grants

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. doi hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit
    Carla S Lopes
    CABD Centro Andaluz de Biologia del Desarrollo Univ Pablo de Olavide CSIC, Ctra Utrera km 1, Sevilla 41013, Spain
    Dev Biol 339:78-88. 2010
    ..However, how this coupling operates is still unclear. Here we show that the transcription factor hth, together with eyeless, is required to stimulate proliferation of progenitor cells...
  2. ncbi Specificity of Distalless repression and limb primordia development by abdominal Hox proteins
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Dev Cell 3:487-98. 2002
    ..Instead, an additional alternatively spliced domain in Ubx is required for Distalless repression but not DNA binding. Thus, the functional specificities of Hox proteins depend on both DNA binding-dependent and -independent mechanisms...
  3. pmc Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
    H Wayne Peng
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 23:2307-19. 2009
    ..Here we provide evidence that Yki can also regulate target genes in conjunction with Homothorax (Hth) and Teashirt (Tsh), two DNA-binding transcription factors expressed in the uncommitted progenitor cells of the ..
  4. pmc Genome-wide tissue-specific occupancy of the Hox protein Ultrabithorax and Hox cofactor Homothorax in Drosophila
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e14686. 2011
    ..In addition, we used ChIP-chip to identify the sites bound by the Hox cofactor, Homothorax (Hth)...
  5. doi Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system
    Ramakrishnan Kannan
    Center for Cellular and Molecular Biology, Hyderabad, India
    Mech Dev 127:137-45. 2010
    ..Furthermore, our data suggest a complex network to regulate CycE expression where AbdA functions as a key regulator...
  6. ncbi Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex
    Ulrich Weihe
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:767-74. 2004
    ..We present evidence that the zinc-finger proteins encoded by the elbow and no ocelli genes act in leg and wing primordia to repress body wall-specifying genes and thereby direct appendage formation...
  7. ncbi Cofactor-interaction motifs and the cooption of a homeotic Hox protein into the segmentation pathway of Drosophila melanogaster
    Ulrike Löhr
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Gottingen, Germany
    Curr Biol 15:643-9. 2005
    ..Strengthening the Ftz/Ftz-F1 interaction led to degeneration of the YPWM and loss of homeotic activity. Thus, small changes in protein sequence can result in a qualitative switch in function during evolution...
  8. pmc Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 135:627-36. 2008
    ..Based on these results, we present a model for how Dpp and Wg, which are present as dorsal and ventral gradients, respectively, induce nearly circular domains of gene expression along the PD axis...
  9. pmc Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in Drosophila
    Siew Woh Choo
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e14778. 2011
    ..We also performed genome-wide analysis of the binding sites for the Hox cofactor Homothorax (Hth), revealing a striking similarity with the Ubx binding profile...
  10. ncbi Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
    G E Rieckhof
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 91:171-83. 1997
    ..Extradenticle (EXD), and encodes a homeodomain protein that shares extensive identity with the product of Meis1, a murine proto-oncogene...
  11. ncbi Getting a molecular grasp on Hox contextual activity
    Samir Merabet
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Trends Genet 21:477-80. 2005
    ..A recent study identified novel Hox molecular partners, whose properties set a conceptual framework to understand how Hox proteins use and integrate contextual information...
  12. pmc The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila
    C Y Pai
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan, Republic of China
    Genes Dev 12:435-46. 1998
    ..We report the cloning of the Drosophila homothorax (hth) gene, a homolog of the mouse Meis1 proto-oncogene that has a homeobox related to that of exd...
  13. ncbi Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS
    E Kurant
    Unit of Genetics, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Development 125:1037-48. 1998
    ..Here we report the phenotypic and molecular analysis of one such gene, homothorax (hth; also named dorsotonals)...
  14. ncbi Control of antennal versus leg development in Drosophila
    F Casares
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 392:723-6. 1998
    ..Third, Antp is a repressor of hth. Fourth, ectopic expression of Meis1, a murine hth homologue, can trigger antennal development elsewhere in the fly...
  15. ncbi Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development
    M Abu-Shaar
    Department of Biochemistry and Molecular Biophysics, Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 125:3821-30. 1998
    homothorax (hth) is a Drosophila member of the Meis family of homeobox genes. hth function is required for the nuclear localization of the Hox cofactor Extradenticle (EXD)...
  16. ncbi Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less
    J Wu
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Germany
    Development 126:109-17. 1999
    ..Drosophila are subdivided into proximal and distal domains by the activity of the homeodomain proteins Homothorax (Hth) and Distal-less (Dll). The expression domains of Dll and Hth are initially reciprocal...
  17. pmc Control of the nuclear localization of Extradenticle by competing nuclear import and export signals
    M Abu-Shaar
    Department of Biochemistry and Molecular Biophysics, Integrated Programin Cellular, Molecular, and Biophysical Studies, Columbia University, New York, New York 10032, USA
    Genes Dev 13:935-45. 1999
    ..Exd) is regulated at the level of its subcellular distribution: It is cytoplasmic in the absence of Homothorax (Hth), a Meis family member, and nuclear in the presence of Hth...
  18. ncbi Patterning mechanisms in the body trunk and the appendages of Drosophila
    G Morata
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 126:2823-8. 1999
    ..We speculate that, although the basic mechanisms are similar, there are significant differences in the manner the body trunk and appendages respond to them...
  19. ncbi A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila
    F Casares
    Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1108, New York, NY 10032 USA
    Development 127:1499-508. 2000
    ..Here we show that wg activates the gene homothorax (hth) in the hinge and that hth is necessary for hinge development...
  20. ncbi Function and regulation of homothorax in the wing imaginal disc of Drosophila
    N Azpiazu
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Development 127:2685-93. 2000
    The gene homothorax (hth) is originally expressed uniformly in the wing imaginal disc but, during development, its activity is restricted to the cells that form the thorax and the hinge, where the wing blade attaches to the thorax, and ..
  21. ncbi Proximal distal axis formation in the Drosophila leg: distinct functions of teashirt and homothorax in the proximal leg
    J Wu
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mech Dev 94:47-56. 2000
    ..Homothorax has been implicated in forming a boundary between proximal and distal segments of the leg. We present evidence that Teashirt is required for the formation of proximal leg segments, but has no role in boundary formation...
  22. ncbi The Hox gene Abdominal-B antagonizes appendage development in the genital disc of Drosophila
    B Estrada
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 128:331-9. 2001
    ..We propose that the genital primordia should be subdivided into two regions, one of them competent to be transformed into an appendage in the absence of Abdominal-B...
  23. ncbi Development. Legs, eyes, or wings--selectors and signals make the difference
    M Affolter
    Biozentrum der Universitat Basel, Abteilung Zellbiologie, Basel CH 4056, Switzerland
    Science 292:1080-1. 2001
  24. ncbi Distal-less and homothorax regulate multiple targets to pattern the Drosophila antenna
    P D Si Dong
    Department of Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 129:1967-74. 2002
    ..We therefore propose that there are significant genetic similarities between the auditory organs of humans and flies...
  25. ncbi The hexapeptide and linker regions of the AbdA Hox protein regulate its activating and repressive functions
    Samir Merabet
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Dev Cell 4:761-8. 2003
    ..Our in vivo data thus reveal functions not previously anticipated from in vitro analyses for the hexapeptide motif in the regulation of Hox activity...
  26. ncbi Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function
    Aurelie Grienenberger
    Laboratoire de Génétique et Biologie du Développement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Development 130:5445-55. 2003
    ..The signal, acting through Mad and Creb, provides spatial information that subdivides the domain of Abdominal A function through direct combinatorial action, conferring specificity and diversity upon Abdominal A activity...
  27. ncbi The role of buttonhead and Sp1 in the development of the ventral imaginal discs of Drosophila
    Carlos Estella
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 130:5929-41. 2003
    ..We propose that this property is a reflection of the initial function of the btd/Sp1 genes that consists of establishing the fate of the ventral disc primordia and determining their pattern and growth...
  28. ncbi Drosophila cardiac tube organogenesis requires multiple phases of Hox activity
    Laurent Perrin
    Laboratoire de Genetique et Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS Université de la Méditerranée, Marseille Cedex 09, 13288 France
    Dev Biol 272:419-31. 2004
    ..This analysis illustrates the mechanisms by which Hox genes can orchestrate organogenesis and, in particular, allows a clear uncoupling of the different phases of Hox activity in this process...
  29. ncbi Direct integration of Hox and segmentation gene inputs during Drosophila development
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics and Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, New York 10032, USA
    Nature 431:653-9. 2004
    ..Our results suggest that these two classes of proteins may collaborate to directly control gene expression at many downstream target genes...
  30. ncbi Patterning function of homothorax/extradenticle in the thorax of Drosophila
    Silvia Aldaz
    Centro de Biologia Molecular, CSIC UAM, Universidad Autonoma de Madrid, Madrid, 28049, Spain
    Development 132:439-46. 2005
    ..Here, we have investigated the role of the homothorax/extradenticle (hth/exd) gene pair in the elaboration of the pattern of the anterior mesothorax (notum)...
  31. ncbi Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex
    Andreas Ebner
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 132:1591-600. 2005
    ..Drosophila, Hox proteins bind to target DNA sequences in association with the Extradenticle (Exd) and Homothorax (Hth) co-factors...
  32. pmc Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing
    Evgeny A Glazov
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Genome Res 15:800-8. 2005
    ..The longest identical, nongapped orthologous match between the three genomes was found within the homothorax (hth) gene...
  33. pmc Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax
    Barbara Noro
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genes Dev 20:1636-50. 2006
    ..We further demonstrate that the mouse ortholog of hth, Meis1, also encodes a HDless isoform, suggesting that homeodomain-less variants of this gene family are evolutionarily ..
  34. pmc Functional specificity of a Hox protein mediated by the recognition of minor groove structure
    Rohit Joshi
    Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1104, New York, NY 10032, USA
    Cell 131:530-43. 2007
    ..Our results suggest that these residues, which are conserved in a paralog-specific manner, confer specificity by recognizing a sequence-dependent DNA structure instead of directly reading a specific DNA sequence...
  35. ncbi Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila
    Delphine Coiffier
    Institut de Biologie du Developpement de Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Case 907 Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Development 135:291-300. 2008
    ..We propose that an evolutionary early function of Hox genes was to modify primitive head morphology with novel functions specialising the trunk appearing later on...
  36. pmc Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Dev Cell 14:86-96. 2008
    ..The "trigger-maintenance" model describes a mechanism by which secreted morphogens act combinatorially to induce the stable expression of target genes...
  37. pmc Cross-regulatory protein-protein interactions between Hox and Pax transcription factors
    Serge Plaza
    Centre National de la Recherche Scientifique Centre de Biologie du Developpement, 118 route de Narbonne, Bâtiment 4R3, 31062 Toulouse, France
    Proc Natl Acad Sci U S A 105:13439-44. 2008
    ..These results demonstrate that the homeodomain supports multiple molecular regulatory functions in addition to protein-DNA and protein-RNA interactions; it is also involved in protein-protein interactions...
  38. pmc The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene
    Daniel J Mckay
    Department of Biochemistry and Molecular Biophysics, Integrated Program in Cellular, Molecular, Structural and Genetic Studies, Columbia University, 701 W 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 136:61-71. 2009
    ..Together, these findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll...
  39. pmc Retinal determination genes as targets and possible effectors of extracellular signals
    Lucy C Firth
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 327:366-75. 2009
    ....
  40. doi Temporal and spatial windows delimit activation of the outer ring of wingless in the Drosophila wing
    Daniel Perea
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma C S I C, Madrid, Spain
    Dev Biol 328:445-55. 2009
    ..Thus, cell proliferation in the proximal-distal axis is controlled by the sequential activation of wingless in the inner ring and the outer ring at different stages of development...
  41. ncbi A new role for hth in the early pre-blastodermic divisions in drosophila
    Lara Salvany
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Cell Cycle 8:2748-55. 2009
    ..In this report, we show that the Homothorax (Hth) transcription factor is maternally provided and that its function is necessary for the proper assembly of the ..
  42. pmc Function and specificity of synthetic Hox transcription factors in vivo
    Dimitrios K Papadopoulos
    Department of Cell Biology, Biozentrum, University of Basel, 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 107:4087-92. 2010
    ..We also demonstrate that synthetic peptides behave largely in a predictable way, by exhibiting Scr-specific phenotypes throughout development, which makes them an important tool for synthetic biology...
  43. pmc Comparing anterior and posterior Hox complex formation reveals guidelines for predicting cis-regulatory elements
    Juli D Uhl
    Division of Developmental Biology, Cincinnati Children s Hospital, 3333 Burnet Ave, MLC 7007, Cincinnati, OH 45229, USA
    Dev Biol 343:154-66. 2010
    ..of each element by forming protein complexes with two cofactor proteins, Extradenticle (Exd) and Homothorax (Hth)...
  44. pmc Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues
    Daniel Karlsson
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    PLoS Biol 8:e1000368. 2010
    ..This study reveals a surprisingly restricted, yet multifaceted, function of both anteroposterior and temporal cues with respect to lineage control and cell fate specification...
  45. doi Regulation of ocellar specification and size by twin of eyeless and homothorax
    Anette Brockmann
    Centro Andaluz de Biologia del Desarrollo CABD, CSIC UPO, Seville, Spain
    Dev Dyn 240:75-85. 2011
    ..a set of simple eyes located on the fly's dorsal head, by studying the expression, regulation, and function of toy, hth, eya, and so, members of the Pax6, Meis, Eya, and Six gene families...
  46. pmc Selection of distinct Hox-Extradenticle interaction modes fine-tunes Hox protein activity
    Mehdi Saadaoui
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique, Universite de la Mediterranee, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 108:2276-81. 2011
    ..These findings identify Hox-PBC interaction as a template for subtle regulation of Hox protein activity that may have played a major role in the diversification of Hox protein function in development and evolution...
  47. doi Concentric zones, cell migration and neuronal circuits in the Drosophila visual center
    Eri Hasegawa
    Frontier Science Organization, Kanazawa University, 13 1 Takaramachi Kanazawa shi, Ishikawa, Japan
    Development 138:983-93. 2011
    ..Thus, genes that show the concentric zones may form a genetic hierarchy to establish neuronal circuits in the medulla...
  48. pmc Interactions among Polycomb domains are guided by chromosome architecture
    Bas Tolhuis
    Division of Molecular Genetics and Centre for Biomedical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS Genet 7:e1001343. 2011
    ..Our results demonstrate that many interactions among PcG target genes exist and that these interactions are guided by overall chromosome architecture...
  49. pmc Yki/YAP, Sd/TEAD and Hth/MEIS control tissue specification in the Drosophila eye disc epithelium
    Tianyi Zhang
    Department of Ophthalmology, Center for Vision Research, and SUNY Eye Institute, SUNY Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 6:e22278. 2011
    ..We also show that knockdown of the transcription factor Homothorax (Hth), known to partner Yki in some developmental contexts, also induces an ectopic retina domain, that Yki and ..
  50. pmc Insights into Hox protein function from a large scale combinatorial analysis of protein domains
    Samir Merabet
    Institut de Biologie du Developpement de Marseille Luminy, UMR6216 CNRS, Parc Scientifique de Luminy, Case 907, Marseille, France
    PLoS Genet 7:e1002302. 2011
    ....
  51. pmc Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168 th Street, HHSC 1104, New York, NY 10032, USA
    Cell 147:1270-82. 2011
    ..Together, these data suggest that emergent DNA recognition properties revealed by interactions with cofactors contribute to transcription factor specificities in vivo...
  52. pmc Variable motif utilization in homeotic selector (Hox)-cofactor complex formation controls specificity
    Katherine M Lelli
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:21122-7. 2011
    ..selector (Hox) proteins often bind DNA cooperatively with cofactors such as Extradenticle (Exd) and Homothorax (Hth) to achieve functional specificity in vivo...
  53. pmc Developmental regulation of chromatin conformation by Hox proteins in Drosophila
    Marios Agelopoulos
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 W 168th Street, HHSC 1104, New York, NY 10032, USA
    Cell Rep 1:350-9. 2012
    ..The pattern of binding by GAGA factor and the variant histone H2Av suggest that they play a role in the regulation of Dll chromatin conformation in expressing and nonexpressing cell types, respectively...
  54. pmc Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammals
    Maria L Spletter
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Exp Cell Res 321:90-8. 2014
    ..Thus, research in Drosophila can provide important mechanistic insight into muscle fiber specification, which is relevant to homologous processes in mammals and to the pathology of muscle diseases. ..
  55. pmc White as a reporter gene to detect transcriptional silencers specifying position-specific gene expression during Drosophila melanogaster eye development
    Y H Sun
    Institute of Molecular Biology, Academia Sinica, Nankang Taipei, Republic of China
    Genetics 141:1075-86. 1995
    ..teashirt is also implicated as a candidate gene. We propose that this "silencer trap"' may be an efficient way of identifying genes involved in imaginal pattern formation...
  56. ncbi Repression of Teashirt marks the initiation of wing development
    Jun Wu
    Developmental Biology Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 129:2411-8. 2002
    ..action of Wingless and Decapentaplegic is required for wing pouch formation and for subsequent repression of Hth. Thus, repression of Tsh defines the presumptive wing earlier in development than repression of Hth, which must ..
  57. pmc Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt
    Jose Bessa
    Instituto de Biologia Molecular e Celular IBMC, 4150 180 Porto, Portugal
    Genes Dev 16:2415-27. 2002
    ..One subdomain, anterior to the MF, expresses two homeobox genes, eyeless (ey) and homothorax (hth), and the zinc-finger gene teashirt (tsh)...
  58. pmc Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila
    Masatomo Kobayashi
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 130:741-51. 2003
    ..These studies expand the functional requirements for extradenticle and homothorax beyond the Hox proteins to a larger family of non-Hox homeodomain proteins...
  59. ncbi Dorso-ventral asymmetric functions of teashirt in Drosophila eye development depend on spatial cues provided by early DV patterning genes
    Amit Singh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Dev 121:365-70. 2004
    ..promoting eye development in dorsal and suppressing eye development in ventral by Wingless mediated Homothorax (HTH) induction [Development 129 (2002) 4271]...
  60. ncbi Signaling circuitries in development: insights from the retinal determination gene network
    Serena J Silver
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Development 132:3-13. 2005
    ..Further study of the RDGN may provide insights into how common cues can generate context-specific responses, a key aspect of developmental regulation that remains poorly understood...
  61. pmc The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells
    Samir Merabet
    Biozentrum der Universitat Basel, Switzerland
    EMBO Rep 6:762-8. 2005
    ..These findings provide a hitherto unknown and interesting link between combinatorial inputs of transcription factors, cell-specific ligand expression and organ morphogenesis...
  62. ncbi Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila
    Jose Bessa
    Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide Consejo Superior de Investigaciones Científicas, Seville, 41013, Spain
    Development 132:5011-20. 2005
    ..Under these conditions, though, terminal eye differentiation proceeds only if tsh expression is transient...
  63. ncbi Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution
    Krishanu Mukherjee
    Department of Biosciences and Nutrition, Karolinska Institutet, and School of Life Sciences, Södertörns högskola, Huddinge, Sweden
    J Mol Evol 65:137-53. 2007
    ..In addition, several instances of gene loss were identified. In conclusion, our comprehensive analysis provides a defining framework for the classification of animal TALE homeobox genes and the understanding of their evolution...
  64. doi Zinc-finger paralogues tsh and tio are functionally equivalent during imaginal development in Drosophila and maintain their expression levels through auto- and cross-negative feedback loops
    Jose Bessa
    Centro Andaluz de Biologia del Desarrollo CABD, CSIC Universidad Pablo de Olavide, Campus UPO, Seville, Spain
    Dev Dyn 238:19-28. 2009
    ..This mechanism might be required to maintain a tight control on the total levels of tio/tsh and could help explaining why Drosophila keeps an apparently dispensable gene...
  65. pmc Non-redundant selector and growth-promoting functions of two sister genes, buttonhead and Sp1, in Drosophila leg development
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS Genet 6:e1001001. 2010
    ..These observations suggest that an ancient Sp8/Dlx gene cassette was used in an early metazoan for primitive limb-like outgrowths and that this cassette was co-opted multiple times for appendage formation in multiple animal phyla...
  66. pmc Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired
    Miki Fujioka
    Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Dev Biol 366:382-92. 2012
    ..cooperative binding sites for En, with the homeodomain-containing Hox cofactors Extradenticle (Exd) and Homothorax (Hth), within two CRMs that drive similar expression patterns...
  67. pmc Extradenticle and homothorax control adult muscle fiber identity in Drosophila
    Anton L Bryantsev
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Dev Cell 23:664-73. 2012
    Here we identify a key role for the homeodomain proteins Extradenticle (Exd) and Homothorax (Hth) in the specification of muscle fiber fate in Drosophila...
  68. pmc Antagonism versus cooperativity with TALE cofactors at the base of the functional diversification of Hox protein function
    María Luisa Rivas
    CABD, CSIC JA Universidad Pablo de Olavide, Seville, Spain
    PLoS Genet 9:e1003252. 2013
    Extradenticle (Exd) and Homothorax (Hth) function as positive transcriptional cofactors of Hox proteins, helping them to bind specifically their direct targets...
  69. pmc Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America Institute for Genomics and Systems Biology and Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 9:e1003753. 2013
    ..the nucleus to regulate gene expression; in Drosophila, the developmental regulators Scalloped (Sd) and Homothorax (Hth) are two such partners...
  70. ncbi The ground state of the ventral appendage in Drosophila
    F Casares
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168 Street, New York, NY 10032, USA
    Science 293:1477-80. 2001
    ..These results raise the possibility that, during evolution, leglike appendages could have developed without selector gene activity...
  71. pmc Mechanism of G1 arrest in the Drosophila eye imaginal disc
    Luis M Escudero
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    BMC Dev Biol 7:13. 2007
    ....
  72. pmc A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax
    Samir Merabet
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 104:16946-51. 2007
    ....
  73. ncbi Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex
    H D Ryoo
    Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1108, New York, NY, USA
    Development 126:5137-48. 1999
    ..bind DNA, it must be in the nucleus, and its nuclear localization requires a third homeodomain protein, Homothorax (HTH)...
  74. ncbi homothorax and iroquois-C genes are required for the establishment of territories within the developing eye disc
    F Pichaud
    Laboratory of Molecular Genetics, Department of Biology, New York University, New York, NY 10003, USA
    Mech Dev 96:15-25. 2000
    ..In addition, we show that the iroquois-complex genes are required for dorsal head development antagonizing the function of homothorax in this region of the disc...
  75. pmc Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin
    Nan Xin
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Development 138:4955-67. 2011
    ....
  76. ncbi Selector genes and limb identity in arthropods and vertebrates
    S D Weatherbee
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Cell 97:283-6. 1999
  77. ncbi A common mechanism for antenna-to-Leg transformation in Drosophila: suppression of homothorax transcription by four HOM-C genes
    L C Yao
    Institute of Genetics, Department of Life Science, National Yang Ming University, Shipai, Taipei, 112, Taiwan, Republic of China
    Dev Biol 211:268-76. 1999
    ..HOM-C genes all exert their effects through a common mechanism: suppressing the transcription of the homothorax (hth) homeobox gene and thereby preventing the nuclear localization of the Extradenticle homeodomain protein...
  78. ncbi Fringe, Notch, and making developmental boundaries
    K D Irvine
    Waksman Institute, Department of Molecular Biology and Biochemistry, 190 Frelinghuysen Rd, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Opin Genet Dev 9:434-41. 1999
    ..Lunatic Fringe has been shown to be required for vertebrate somitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling...
  79. ncbi Regeneration in insects
    J L Marsh
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA
    Semin Cell Dev Biol 10:365-75. 1999
    ..Each of the regulatory networks could themselves serve as the subject of a detailed review and that is beyond the scope of this discussion. Here we will focus on the interplay between the regulatory networks in patterning the tissue...
  80. ncbi The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development
    B Kerber
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Development 128:1231-8. 2001
    ..Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development...
  81. ncbi The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc
    J D Lee
    Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 128:1519-29. 2001
    ..However, Wingless signaling does not lead to ventral mirror expression, implying the existence of ventral repressors...
  82. ncbi Limb development: getting down to the ground state
    B Starling Emerald
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117, Heidelberg, Germany
    Curr Biol 11:R1025-7. 2001
    ..Recent genetic studies on the Antennapedia and Homothorax genes of Drosophila raise questions about the nature of this ground state appendage...
  83. ncbi Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge
    David del Alamo Rodríguez Dd
    Centro de Biología Molecular Severo Ochoa C S I C, Facultad de Ciencias CV, Universidad Autónoma Cantoblanco, 28049 Madrid, Spain
    Development 129:3995-4004. 2002
    ..We discuss the role of wingless in patterning the wing hinge...
  84. ncbi Eyeless collaborates with Hedgehog and Decapentaplegic signaling in Drosophila eye induction
    Madhuri Kango-Singh
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan, Republic of China
    Dev Biol 256:49-60. 2003
    ..Coexpression experiments show that EY needs to collaborate with high level of HH and DPP to induce ectopic eye formation. Ectopic eye formation also requires the activation of an eye-specific enhancer of the endogenous hh gene...
  85. ncbi Evolution of transcription factor function
    Cheryl C Hsia
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Genet Dev 13:199-206. 2003
    ..Interestingly, recent studies provide evidence that changes in transcription factor protein sequence can affect the regulation of only a subset of target genes, even in the same cells of a developing animal...
  86. ncbi A novel double-stranded RNA-binding protein, disco interacting protein 1 (DIP1), contributes to cell fate decisions during Drosophila development
    Dorothy DeSousa
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Biol Chem 278:38040-50. 2003
    ..A role for DIP1 in epigenetic mechanisms that lead to the establishment and/or maintenance of cell fate specification is discussed...
  87. ncbi Hox gene cross-regulatory interactions in the embryonic brain of Drosophila
    Simon G Sprecher
    Institute of Zoology, Biocenter Pharmacenter University of Basel, Klingelbergstr 50, CH 4056 Basel, Switzerland
    Mech Dev 121:527-36. 2004
    ..insight into the cross-regulatory interactions of Hox genes in embryonic brain development and suggest that specification of tritocerebral neuronal identity requires equilibrated levels of a Hox protein and Hth and n-Exd cofactors.
  88. pmc A piggyBac transposon gene trap for the analysis of gene expression and function in Drosophila
    Christopher P Bonin
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genetics 167:1801-11. 2004
    ..These experiments highlight the utility of the PBss system for expanding the functional genomics tools that are available in Drosophila...
  89. ncbi Tarsus determination in Drosophila melanogaster
    Anthony Percival-Smith
    Department of Biology, University of Western Ontario, London, Canada
    Genome 48:712-21. 2005
    ..Clonal ectopic overexpression of ANTP did not repress the expression of the arista determining protein Homothorax (HTH) in early 3rd stadium antennal imaginal discs...
  90. ncbi Transcriptional activation by extradenticle in the Drosophila visceral mesoderm
    Brian G Stultz
    Cellular and Tissue Therapy Branch, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM 730, Bldg 29B, Rm 1E16, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Dev Biol 290:482-94. 2006
    ..We demonstrate that extradenticle (exd) and homothorax (hth) are also required for dpp expression in this location, as well as in PS3, at the site of the developing gastric ..
  91. ncbi "Mir"acles in hox gene regulation
    Vivek S Chopra
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Bioessays 28:445-8. 2006
    ..This study unveils a new complexity and finesse to the regulation of hox gene expression pattern that is needed for determining the anteroposterior body axis in all bilaterians...
  92. ncbi The specification of a highly derived arthropod appendage, the Drosophila labial palps, requires the joint action of selectors and signaling pathways
    Laurent Joulia
    Centre de Biologie du Developpement, CNRS, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
    Dev Genes Evol 216:431-42. 2006
    ..of the Hox selector genes proboscipedia (pb) and Sex combs reduced (Scr), and the antennal selectors homothorax (hth) and spineless (ss) in labial specification, by tissue-directed mitotic recombination...
  93. pmc Cytochrome c-d regulates developmental apoptosis in the Drosophila retina
    César S Mendes
    Howard Hughes Medical Institute, Strang Laboratory of Cancer Research, The Rockefeller University, 1230 York Avenue Box 252, 10021, New York, New York 10021, USA
    EMBO Rep 7:933-9. 2006
    ..Collectively, our results indicate a role of Cyt c in caspase regulation of Drosophila somatic cells...
  94. ncbi Organization of the peripheral fly eye: the roles of Snail family transcription factors in peripheral retinal apoptosis
    Hui Ying Lim
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 133:3529-37. 2006
    ..Furthermore, we describe a later requirement for Snail family proteins in the 2 degrees and 3 degrees pigment cells throughout the main body of the eye...
  95. ncbi Continuity versus split and reconstitution: exploring the molecular developmental corollaries of insect eye primordium evolution
    Markus Friedrich
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA
    Dev Biol 299:310-29. 2006
    ....
  96. ncbi The JAK/STAT pathway regulates proximo-distal patterning in Drosophila
    Aidee Ayala-Camargo
    Pharmacology Department, New York University School of Medicine, New York, New York 10016 6402, USA
    Dev Dyn 236:2721-30. 2007
    ....
  97. ncbi Complex genetic interactions govern the temporal effects of Antennapedia on antenna-to-leg transformations in Drosophila melanogaster
    Ian Dworkin
    Department of Zoology, University of Toronto, 25 Herbord St, Toronto, Ontario M5S 3G5, Canada
    J Genet 86:111-23. 2007
    The putative regulatory relationships between Antennapedia (Antp), spalt major (salm) and homothorax (hth) are tested with regard to the sensitive period of antenna-to-leg transformations...
  98. pmc Transformation of eye to antenna by misexpression of a single gene
    Hao A Duong
    Department of Chemistry and Biochemistry, University of California Los Angeles, 607 Charles E Young Drive East, Los Angeles, CA 90095 1569, USA
    Mech Dev 125:130-41. 2008
    ..The finding that this transformation occurs only in the eye disc, and not in other imaginal discs, suggests a close developmental and therefore evolutionary relationship between eyes and antennae...
  99. doi Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen
    Hassina Benchabane
    Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Development 135:963-71. 2008
    ..We conclude that Apc activity is not present in vast excess, but instead is near the minimal level required for accurate graded responses to the Wg morphogen...
  100. pmc The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets
    Yan I Liu
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Dev Biol 323:41-52. 2008
    ..Our results argue that WG signaling activates target gene expression partly by overcoming the chromatin barrier maintained by ISWI and ACF1...
  101. doi Notch signalling coordinates tissue growth and wing fate specification in Drosophila
    Neus Rafel
    ICREA and Institute for Research in Biomedicine IRB Científic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
    Development 135:3995-4001. 2008
    ..These results highlight a crucial role of Notch in linking proliferation and fate specification in the developing wing primordium...

Research Grants7

  1. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
    ..Further, these in vivo studies may help in understanding the basis of some dysmorphologies in humans. ..
  2. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  3. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  4. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  5. Molecular Mechanisms of Segmentation
    Cordelia Rauskolb; Fiscal Year: 2005
    ..abstract_text> ..
  6. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2005
    ..Finally, we have identified a collection of mutants affecting disc growth patterns that serve as an enriched collection of new candidate genes to participate in these events. ..
  7. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..