lab

Summary

Gene Symbol: lab
Description: labial
Alias: BG:DS00004.9, CG1264, Dm lab, DmLab, Dmel\CG1264, Dmlab, EfR9, F121, F24, F90, F90-2, LAB, Lab, l(3)01241, l(3)84Ac, CG1264 gene product from transcript CG1264-RA, CG1264-PA, CG1264-PB, lab-PA, lab-PB
Species: fruit fly

Top Publications

  1. ncbi Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13
    Adrian Streit
    Department of Biology, University of Fribourg, Perolles, Fribourg, CH 1700, Switzerland
    Dev Biol 242:96-108. 2002
  2. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  3. ncbi Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system
    J G Heuer
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405
    Development 115:35-47. 1992
  4. ncbi Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster: evidence for both positive and negative autogenous regulation
    S Chouinard
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405
    Development 113:1267-80. 1991
  5. ncbi Induction across germ layers in Drosophila mediated by a genetic cascade
    K Immergluck
    Zoological Institute, University of Zurich, Switzerland
    Cell 62:261-8. 1990
  6. ncbi Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos
    R Reuter
    Howard Hughes Medical Institute, University of Colorado, Boulder 80309 0347
    Development 110:1031-40. 1990
  7. ncbi A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis
    G E Panganiban
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Development 110:1041-50. 1990
  8. ncbi A genetic and developmental analysis of mutations in labial, a gene necessary for proper head formation in Drosophila melanogaster
    V K Merrill
    Department of Biology, Indiana University, Bloomington 47405
    Dev Biol 135:376-91. 1989
  9. ncbi The specificity of homeotic gene function
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioessays 17:855-63. 1995
  10. ncbi Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
    H Popperl
    Medical Research Council, National Institute for Medical Research, London, England
    Cell 81:1031-42. 1995

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. ncbi Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13
    Adrian Streit
    Department of Biology, University of Fribourg, Perolles, Fribourg, CH 1700, Switzerland
    Dev Biol 242:96-108. 2002
    ..The second regulatory sequence is sufficient to drive correct early embryonic expression of ceh-13. Interestingly, this enhancer fragment acts as a response element of the Wnt/WG signaling pathway in Drosophila embryos...
  2. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  3. ncbi Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system
    J G Heuer
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405
    Development 115:35-47. 1992
    ..In addition, we also report the effects of ectopic expression of the homeotic genes labial (lab), Deformed (Dfd), Scr, Antp or Ubx on the normal development of sensory organs in the embryonic PNS...
  4. ncbi Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster: evidence for both positive and negative autogenous regulation
    S Chouinard
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405
    Development 113:1267-80. 1991
    The homeotic gene labial (lab) is required for proper development of the embryonic and adult head in Drosophila melanogaster. The lab gene product accumulates in a complex pattern in both embryonic and imaginal tissue...
  5. ncbi Induction across germ layers in Drosophila mediated by a genetic cascade
    K Immergluck
    Zoological Institute, University of Zurich, Switzerland
    Cell 62:261-8. 1990
    ..Positional instruction of this kind may be needed since the endoderm, unlike the mesoderm, appears unsegmented at first as it originates from two primordia near the embryonic poles, outside the realm of segmentation genes...
  6. ncbi Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos
    R Reuter
    Howard Hughes Medical Institute, University of Colorado, Boulder 80309 0347
    Development 110:1031-40. 1990
    ..One consequence of dpp expression is the induction of labial (lab) in the underlying endoderm cells...
  7. ncbi A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis
    G E Panganiban
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Development 110:1041-50. 1990
    ..across the apposing endodermal cell layer in a region of the endoderm that expresses the homeotic gene labial (lab)...
  8. ncbi A genetic and developmental analysis of mutations in labial, a gene necessary for proper head formation in Drosophila melanogaster
    V K Merrill
    Department of Biology, Indiana University, Bloomington 47405
    Dev Biol 135:376-91. 1989
    We have undertaken a developmental genetic analysis of labial (lab), the most proximal gene in the Antennapedia complex (ANT-C) of Drosophila melanogaster...
  9. ncbi The specificity of homeotic gene function
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioessays 17:855-63. 1995
    ..Although exd provides part of the answer as to how specificity is achieved, there may be additional cofactors and mechanisms that have yet to be identified...
  10. ncbi Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
    H Popperl
    Medical Research Council, National Institute for Medical Research, London, England
    Cell 81:1031-42. 1995
    ..demonstrated that the conserved elements are involved in a positive autoregulatory loop dependent on labial (lab) family members...
  11. ncbi Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins
    C P Hunter
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0554, USA
    Nature 377:229-32. 1995
    ..Together these findings suggest that factors important for target recognition by specific Hox proteins have been conserved throughout much of the animal kingdom...
  12. ncbi Homeotic genes of Drosophila
    G Morata
    Centro de Biologia Molecular CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Curr Opin Genet Dev 3:606-14. 1993
    ..Comparison between Drosophila and other species suggests a common functional organization of homeotic complexes in the animal kingdom...
  13. ncbi Ectopic decapentaplegic in the Drosophila midgut alters the expression of five homeotic genes, dpp, and wingless, causing specific morphological defects
    K Staehling-Hampton
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Dev Biol 164:502-12. 1994
    ....
  14. ncbi Colinearity and functional hierarchy among genes of the homeotic complexes
    D Duboule
    Département de Zoologie et Biologie Animale, Universite de Geneve, Switzerland
    Trends Genet 10:358-64. 1994
    ....
  15. ncbi Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic
    D Nellen
    Zoologisches Institut Universität Zürich, Switzerland
    Cell 78:225-37. 1994
    ..We propose that specification of distinct cell fates in response to different concentrations of dpp may be achieved combinatorially by the sax and tkv receptors...
  16. ncbi Rescue of Drosophila labial null mutant by the chicken ortholog Hoxb-1 demonstrates that the function of Hox genes is phylogenetically conserved
    B Lutz
    Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 10:176-84. 1996
    ..We have studied this issue with the Drosophila labial (lab) gene and its chicken ortholog gHoxb-1...
  17. pmc An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif
    S K Chan
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    EMBO J 15:2476-87. 1996
    ..that a 20 bp oligonucleotide from the 5' region of the mouse Hoxb-1 gene, a homolog of Drosophila labial (lab), is sufficient to direct an expression pattern in Drosophila that is very similar to endogenous lab...
  18. ncbi Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA
    Trends Genet 12:258-62. 1996
    ....
  19. ncbi Switching the in vivo specificity of a minimal Hox-responsive element
    S K Chan
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Development 124:2007-14. 1997
    ..Thus, the choice of Hox partner, and therefore Hox target genes, depends on subtle differences between Hox-PBC binding sites...
  20. ncbi D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction
    J Riese
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 124:3353-61. 1997
    ....
  21. ncbi Endoderm induction in Drosophila: the nuclear targets of the inducing signals
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Genet Dev 7:683-8. 1997
  22. pmc Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling
    N C Grieder
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    EMBO J 16:7402-10. 1997
    ..We have identified a single essential Labial (LAB)/EXD-binding site in a Decapentaplegic (DPP)-responsive enhancer of the homeotic gene lab which drives expression ..
  23. ncbi Mutations of alpha spectrin and labial block cuprophilic cell differentiation and acid secretion in the middle midgut of Drosophila larvae
    R R Dubreuil
    Department of Pharmacological and Physiological Sciences, University of Chicago, 947 East 58th Street, Chicago, Illinois, 60637, USA
    Dev Biol 194:1-11. 1998
    ..We propose that the alpha-specrg41 mutation in Drosophila interferes with the polarized activities of homologous molecules that drive acid secretion in cuprophilic cells...
  24. ncbi Homeotic gene action in embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, University of Basel, Basel, Switzerland
    Development 125:1579-89. 1998
    ..Our findings demonstrate that the action of the homeotic genes labial and Deformed are required for neuronal differentiation in the developing brain of Drosophila...
  25. ncbi Shaping animal body plans in development and evolution by modulation of Hox expression patterns
    G Gellon
    Department of Biology, Yale University, New Haven, CT, USA
    Bioessays 20:116-25. 1998
    ....
  26. ncbi Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex
    J M Passner
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 397:714-9. 1999
    ..Together, these protein-DNA and protein-protein interactions define the general principles by which homeotic proteins interact with Extradenticle (or Pbx1) to affect development along the anterior-posterior axis of animals...
  27. pmc The anterior determinant bicoid of Drosophila is a derived Hox class 3 gene
    M Stauber
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg 11, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 96:3786-9. 1999
    ....
  28. pmc Nuclear interpretation of Dpp signaling in Drosophila
    M Affolter
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4026 Basel, Switzerland
    EMBO J 20:3298-305. 2001
    ..It remains to be seen whether similar molecular mechanisms operate in the nucleus in vertebrate systems...
  29. ncbi A HOX complex, a repressor element and a 50 bp sequence confer regional specificity to a DPP-responsive enhancer
    T Marty
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 128:2833-45. 2001
    ....
  30. ncbi Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 128:4781-8. 2001
    ..This suggests that in embryonic brain development, differences in Hox gene action rely mainly on cis-acting regulatory elements and not on Hox protein specificity...
  31. ncbi An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila
    Frank Hirth
    Institute of Zoology, Biozentrum Pharmazentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 130:2365-73. 2003
    ..This suggests that a tripartite organization of the embryonic brain was already established in the last common urbilaterian ancestor of protostomes and deuterostomes...
  32. ncbi A new split of the Hox gene complex in Drosophila: relocation and evolution of the gene labial
    Barbara Negre
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Bellaterra Barcelona Spain
    Mol Biol Evol 20:2042-54. 2003
    ..discovered in the species of the Drosophila repleta group, which relocated the most anterior gene of the complex, lab, to a distant chromosomal site near the two most posterior Hox genes, abd-A and Abd-B...
  33. ncbi Hox gene cross-regulatory interactions in the embryonic brain of Drosophila
    Simon G Sprecher
    Institute of Zoology, Biocenter Pharmacenter University of Basel, Klingelbergstr 50, CH 4056 Basel, Switzerland
    Mech Dev 121:527-36. 2004
    ....
  34. ncbi Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex
    Andreas Ebner
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 132:1591-600. 2005
    ..Here, we report that the regulation of a newly identified Lab target gene does not rely on the previously established consensus Lab/Exd/Hth-binding site, but on a strongly ..
  35. pmc Conservation of regulatory sequences and gene expression patterns in the disintegrating Drosophila Hox gene complex
    Barbara Negre
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Genome Res 15:692-700. 2005
    ..Rather, the organization of Hox genes is modular, and their clustering seems the result of phylogenetic inertia more than functional necessity...
  36. ncbi Tarsus determination in Drosophila melanogaster
    Anthony Percival-Smith
    Department of Biology, University of Western Ontario, London, Canada
    Genome 48:712-21. 2005
    ..iii) Ectopic overexpression of ANTP, Labial (LAB), Deformed (DFD), SCR, Ultrabithorax (UBX), Abdominal-A (ABD-A), or Abdominal-B (ABD-B), using the dppGAL4 driver, ..
  37. pmc Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax
    Barbara Noro
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genes Dev 20:1636-50. 2006
    ..We further demonstrate that the mouse ortholog of hth, Meis1, also encodes a HDless isoform, suggesting that homeodomain-less variants of this gene family are evolutionarily ancient...
  38. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007
    ..By integrating these parameters, general conclusions emerge that can help solve the aforementioned dilemma...
  39. pmc Comparing anterior and posterior Hox complex formation reveals guidelines for predicting cis-regulatory elements
    Juli D Uhl
    Division of Developmental Biology, Cincinnati Children s Hospital, 3333 Burnet Ave, MLC 7007, Cincinnati, OH 45229, USA
    Dev Biol 343:154-66. 2010
    ..Based upon these findings, we suggest a general set of guidelines to serve as a basis for designing bioinformatics algorithms aimed at identifying Hox regulatory elements using the wealth of recently sequenced genomes...
  40. pmc Quiescent gastric stem cells maintain the adult Drosophila stomach
    Marie Strand
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:17696-701. 2011
    ..Characterization of the GSSC lineage in Drosophila, with striking similarities to mammals, will advance the study of both homeostatic and pathogenic processes in the stomach...
  41. pmc Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168 th Street, HHSC 1104, New York, NY 10032, USA
    Cell 147:1270-82. 2011
    ..Together, these data suggest that emergent DNA recognition properties revealed by interactions with cofactors contribute to transcription factor specificities in vivo...
  42. pmc Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex
    M Mlodzik
    Biozentrum, University of Basel, Switzerland
    EMBO J 7:2569-78. 1988
    ..The structure and complete sequence are presented. Deletion analysis indicates that the cloned gene, F24, most likely corresponds to the labial (lab) gene...
  43. ncbi Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development
    R J Diederich
    Department of Biology, Indiana University, Bloomington 47405
    Genes Dev 3:399-414. 1989
    The labial (lab) gene of Drosophila melanogaster is necessary for the proper development of the embryonic (larval) and adult head...
  44. ncbi Specification of a single cell type by a Drosophila homeotic gene
    S Hoppler
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, England
    Cell 76:689-702. 1994
    ..We show here that expression of this gene, labial (lab), coincides with copper cells, highly specialized cells of the larval midgut...
  45. pmc A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells
    H Nakagoshi
    Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Genes Dev 12:2724-34. 1998
    ..Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia...
  46. ncbi An autoregulatory function of Dfos during Drosophila endoderm induction
    D Szuts
    MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    Mech Dev 98:71-6. 2000
    ..We show that Dfos expression is stimulated by Egfr signalling. Finally, we find that Dfos function is required for its own upregulation. Thus, endoderm induction is based on at least four tiers of positive autoregulatory feedback loops...
  47. ncbi The evolving role of Hox genes in arthropods
    M Akam
    Wellcome CRC Institute, Cambridge, UK
    Dev Suppl . 1994
    ..They show conserved patterns of expression in the nervous system, but not during early development...
  48. ncbi Cross-regulation of Hox genes in the Drosophila melanogaster embryo
    D F Miller
    Department of Biology, Howard Hughes Medical Institute, Indiana University, Bloomington, IN 47405, USA
    Mech Dev 102:3-16. 2001
    ..for tissue specific interactions between various Hox genes and demonstrate the induction of endodermal labial (lab) by ectopically expressed Ultrabithorax outside the visceral mesoderm (VMS)...
  49. ncbi Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster
    B T Wakimoto
    Dev Biol 102:147-72. 1984
    ..The mutant phenotypes suggest, in addition to ensuring proper segment identity, the wild-type alleles of the 84A-84B1,2 genes are necessary for normal segmentation and elongation of the germ band and normal head involution...
  50. ncbi Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses
    R G Wisotzkey
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 125:1433-45. 1998
    ..We propose that this provides a general model for Smad4/MEDEA function in signaling by the TGF-beta family...
  51. ncbi Understanding the genetic basis of morphological evolution: the role of homeotic genes in the diversification of the arthropod bauplan
    A POPADIC
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405, USA
    Int J Dev Biol 42:453-61. 1998
    ..In this review, we will address the question of the possible role of four Hox genes: labial (lab), proboscipedia (pb), Deformed (Dfd), and Sex combs reduced (Scr) in the morphological evolution of arthropods, ..
  52. ncbi Debatable issues. Interview by Alain Ghysen
    L Wolpert
    Dept of Anatomy and Developmental Biology, University College London Medical School, United Kingdom
    Int J Dev Biol 42:511-8. 1998
    ..Obviously the discussion did not provide any firm answers to any of these questions. Perhaps more importantly, it provides a vivid picture of two contrasting ways of thinking about developmental problems...
  53. ncbi Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex
    H D Ryoo
    Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1108, New York, NY, USA
    Development 126:5137-48. 1999
    ..These data suggest that Hox proteins often function as part of a multiprotein complex, composed of HTH, Hox, and EXD proteins, bound to DNA...
  54. ncbi Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
    C M Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 126:5441-52. 1999
    ..These results extend prior evidence of a ligand-receptor relationship between Wnt and Frizzled proteins and suggest that Fz and Fz2 are the primary receptors for Wg in Drosophila...
  55. ncbi Expression, regulation and function of the homeobox gene empty spiracles in brain and ventral nerve cord development of Drosophila
    B Hartmann
    Institute of Zoology, University of Basel, Rheinsprung 9, 4051, Basel, Switzerland
    Mech Dev 90:143-53. 2000
    ..In the posterior brain and VNC ems is necessary for correct axonal pathfinding of specific interneurons. Rescue experiments indicate that the murine Emx2 gene can partially replace the fly ems gene in CNS development...
  56. ncbi Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila
    Delphine Coiffier
    Institut de Biologie du Developpement de Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Case 907 Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Development 135:291-300. 2008
    ..We propose that an evolutionary early function of Hox genes was to modify primitive head morphology with novel functions specialising the trunk appearing later on...
  57. doi Essential role of the glycosyltransferase sxc/Ogt in polycomb repression
    Maria Cristina Gambetta
    Gene Expression Programme, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Science 325:93-6. 2009
    ..Polycomb repression appears to be a critical function of Sxc/Ogt in Drosophila and may be mediated by the glycosylation of Polyhomeotic...
  58. pmc Hox proteins coordinate peripodial decapentaplegic expression to direct adult head morphogenesis in Drosophila
    Brian G Stultz
    Division of Cell and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Dev Biol 369:362-76. 2012
    ..Thus Hox/BMP interactions in the peripodial epithelium of the eye-antennal disc contribute inductively to the shape of the external form of the adult Drosophila head...
  59. pmc Dual role for Hox genes and Hox co-factors in conferring leg motoneuron survival and identity in Drosophila
    Myungin Baek
    Department of Biological Sciences, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 140:2027-38. 2013
    ..Thus, in addition to being essential for survival, Hox and hth are required to specify accurate MN morphologies in a level-dependent manner...
  60. pmc Molecular mechanism and functional significance of acid generation in the Drosophila midgut
    Gayle Overend
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Sci Rep 6:27242. 2016
    ..These results demonstrate that the acidic gut region protects the insect and gut microbiome from pathological disruption, and shed light on the mechanisms by which low pH can be maintained in the absence of H(+), K(+) ATPase. ..
  61. pmc Gene expression patterns in primary neuronal clusters of the Drosophila embryonic brain
    Simon G Sprecher
    Biozentrum, University of Basel, Basel, Switzerland
    Gene Expr Patterns 7:584-95. 2007
    ....
  62. doi Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex
    Swarnava Roy
    NIDDK Metabolic Diseases Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Genet Genomics 285:113-23. 2011
    ..A control gene, Dref, was not affected. A full understanding of the regulation of ANT-C genes during development will have to take the role of BEAF into account...
  63. ncbi Organogenesis in Drosophila melanogaster: embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes
    S Panzer
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 114:49-57. 1992
    ....
  64. ncbi The role of the teashirt gene in trunk segmental identity in Drosophila
    L Röder
    Laboratoire de Génétique et Biologie Cellulaires, CNRS Case 907, Centre Universitaire Marseille Luminy, France
    Development 115:1017-33. 1992
    ..These genes act synergistically to suppress the expression of the procephalic gene labial (lab) in subsets of cells in each segment of the trunk...
  65. pmc Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue
    P G Feinstein
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 140:573-86. 1995
    ..These results illustrate potentially general rules about the homeotic control of target gene expression and suggest that subtractive hybridization can be used to isolate interesting homeotic target genes...
  66. ncbi Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis
    M Affolter
    Biozentrum, Universitat Basel, Switzerland
    Development 120:3105-17. 1994
    ..The requirements for tkv in dorsal closure, visceral mesoderm and trachea development assign novel functions to dpp or a closely related member of the TGF beta superfamily...
  67. ncbi Signaling by wingless in Drosophila
    J Klingensmith
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, California 94305
    Dev Biol 166:396-414. 1994
    ..Where appropriate, wingless signaling will be compared to the activity of vertebrate Wnt proteins...
  68. ncbi The Sex combs reduced gene of Drosophila melanogaster has multiple transcripts
    D J Andrew
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5247
    Gene 152:149-55. 1995
    ..As with most of the D. melanogaster homeotic genes, Scr has alternative exons...
  69. pmc Discovery and genetic definition of the Drosophila Antennapedia complex
    R Denell
    Division of Biology, Kansas State University, Manhattan 66506 4901
    Genetics 138:549-52. 1994
  70. ncbi Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A
    K Staehling-Hampton
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Cell Growth Differ 5:585-93. 1994
    ....
  71. ncbi Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Development 117:1199-210. 1993
    ..the endodermal germ layers has recently been described in the regulation of the Drosophila homeotic gene labial (lab)...
  72. ncbi The arthropod initiator: the capsite consensus plays an important role in transcription
    L Cherbas
    Department of Biology, Indiana University, Bloomington 47405
    Insect Biochem Mol Biol 23:81-90. 1993
    ....
  73. pmc A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer
    S K Chan
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 93:5223-8. 1996
    ..These results demonstrate that extradenticle prefers to bind cooperatively with different HOX proteins depending on subtle differences in the heterodimer binding site...
  74. pmc bowel, an odd-skipped homolog, functions in the terminal pathway during Drosophila embryogenesis
    L Wang
    E A Doisy Department of Biochemistry and Molecular Biology, St Louis University Medical School, MO 63104, USA
    EMBO J 15:3182-96. 1996
    ....
  75. ncbi High nucleotide sequence variation in a region of low recombination in Drosophila simulans is consistent with the background selection model
    M T Hamblin
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Evol 13:1133-40. 1996
    ..melanogaster. Alternatively, the deleterious mutation rate may be smaller in D. simulans, or balancing selection may be acting nearby, thereby reducing the effect of background selection...
  76. ncbi The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
    T Kadowaki
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:3116-28. 1996
    ..We identified a human sequence related to Porc suggesting the existence of a family of proteins involved in processing of Wnts...
  77. pmc A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction
    S Eresh
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 16:2014-22. 1997
    ..Therefore, a CREB protein may act as a nuclear target, or as a partner of a nuclear target, for Dpp signalling in the embryonic midgut...
  78. ncbi A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs
    L P Keegan
    Department of Cell Biology, Basel University Biozentrum, Switzerland
    Mech Dev 63:145-57. 1997
    ..Testing a reporter gene construct with mutated binding sites in mouse embryos shows that HB1 is also active in the expression domains of posterior Hox genes in the mouse neural tube...
  79. ncbi Why are Hox genes clustered?
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioessays 19:661-4. 1997
    ..Moreover, characterizing the activity of one of these mouse enhancers in Drosophila illustrates that despite many similarities, not all Hox clusters are built in the same way...
  80. ncbi Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
    G E Rieckhof
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 91:171-83. 1997
    ..These data suggest a novel and evolutionarily conserved mechanism for regulating HOX activity in which a direct protein-protein interaction between EXD and HTH results in EXD's nuclear translocation...
  81. ncbi The wingless gene is required for embryonic brain development in Drosophila
    S Richter
    Institute of Zoology, University of Basel, Rheinsprung 9, CH 4051 Basel, Switzerland
    Dev Genes Evol 208:37-45. 1998
    ..We propose that an important role of wingless in this part of the developing brain is the determination of neural cell fate...
  82. pmc Needs and targets for the multi sex combs gene product in Drosophila melanogaster
    O Saget
    Centre de Genetique Moleculaire du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette Cedex, France
    Genetics 149:1823-38. 1998
    ..We discuss these data in view of the numerous functions of PcG genes during development...
  83. ncbi Complexity of EGF receptor signalling revealed in Drosophila
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Genet Dev 8:407-11. 1998
    ..The integration of signalling pathways into networks is beginning to be understood...
  84. pmc The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of Drosophila
    I D Zorin
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 152:1045-55. 1999
    ..These results suggest that the lawc protein is involved in regulating the higher-order organization of chromatin...
  85. ncbi A sequence motif distinct from Hox binding sites controls the specificity of a Hox response element
    X Li
    Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 126:5581-9. 1999
    ..Thus, cofactor binding sites that are separate and distinct from homeodomain binding sites can dictate the regulatory specificity of a Hox response element...
  86. ncbi knot is required for the hypopharyngeal lobe and its derivatives in the Drosophila embryo
    M Seecoomar
    Department of Biological Sciences, Barnard College, 3009 Broadway, New York, NY 10027 USA
    Mech Dev 91:209-15. 2000
    ....
  87. ncbi The Drosophila tumor suppressor gene lethal(2)giant larvae is required for the emission of the Decapentaplegic signal
    N Arquier
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France
    Development 128:2209-20. 2001
    ....
  88. ncbi Evolution of transcription factor function
    Cheryl C Hsia
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Genet Dev 13:199-206. 2003
    ..Interestingly, recent studies provide evidence that changes in transcription factor protein sequence can affect the regulation of only a subset of target genes, even in the same cells of a developing animal...
  89. ncbi The evolution of HOM-C homeoboxes in the Dipteran family Drosophilidae
    R DeSalle
    Division of Invertebrates, American Museum of Natural History, 79th Street at Central Park West, New York, NY 10024, USA
    Insect Mol Biol 12:345-51. 2003
    ..In addition, different patterns of codon bias were detected in homeoboxes interrupted with introns when compared to homeoboxes that are uninterrupted...
  90. ncbi Subdivision and developmental fate of the head mesoderm in Drosophila melanogaster
    Begona De Velasco
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Genes Evol 216:39-51. 2006
    ..The lSHM contributes hemocytes, as well as the nephrocytes forming the subesophageal body, also called garland cells...
  91. ncbi Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax
    Ella Tour
    Section in Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 132:5271-81. 2005
    ..These results suggest that the N-terminal region containing the SSYF motif has been conserved in many Hox proteins for its role in transcriptional activation...
  92. pmc Fast sequence evolution of Hox and Hox-derived genes in the genus Drosophila
    Sònia Casillas
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    BMC Evol Biol 6:106. 2006
    ..However, some observations point to a completely different scenario. Hox genes are usually highly conserved inside the homeobox, but very variable outside it...
  93. ncbi Notch-, Wingless-, and Dpp-mediated signaling pathways are required for functional specification of Drosophila midgut cells
    Ryushin Tanaka
    Graduate School of Natural and Science Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Dev Biol 304:53-61. 2007
    ..These results provide valuable insights into the molecular mechanism underlying functional specification...
  94. pmc Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins
    Christian Beisel
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 104:16615-20. 2007
    ..Besides its presumptive function in recruiting PcG complexes to their site of action, our results now uncover that Pho plays an additional role in the repression of already induced genes...
  95. pmc FoxK mediates TGF-beta signalling during midgut differentiation in flies
    Sergio Casas-Tinto
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Cell Biol 183:1049-60. 2008
    ..Thus, we propose that the combined activity of the TGF-beta target genes FoxK and Dfos is critical for the direct activation of lab in the endoderm.
  96. doi Expression of the apoptosis gene reaper in homeotic, segmentation and other mutants in Drosophila
    Zongzhao Zhai
    MPI for Development Biology, Department of Molecular Bilogy, AC I Lohmann, 72076 Tubingen, Germany
    Gene Expr Patterns 9:357-63. 2009
    ....
  97. pmc Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
    Johanna C Scheuermann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 465:243-7. 2010
    ..Polycomb gene silencing may thus entail a dynamic balance between H2A ubiquitination by PRC1 and dRAF, and H2A deubiquitination by PR-DUB...
  98. ncbi The genetics of brain development: conserved programs in flies and mice
    S Thor
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Neuron 15:975-7. 1995
  99. pmc Two different thresholds of wingless signalling with distinct developmental consequences in the Drosophila midgut
    S Hoppler
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 14:5016-26. 1995
    ..Thus, midgut cells respond differentially to distinct wingless thresholds in terms of both gene control and cellular differentiation...
  100. ncbi The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family
    K Arora
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717, USA
    Cell 81:781-90. 1995
    ..Genetic interactions and the strikingly similar phenotypes of mutations in shn and the dpp receptors encoded by thick veins and punt suggest that shn plays a downstream role in dpp signaling...

Research Grants5

  1. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2004
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  2. Integrated Approcahes to Find Hox-regulated DNA Elements
    Richard Mann; Fiscal Year: 2008
    ..Once these methods are worked out, they will be applicable to a wide variety of problems in biology. [unreadable] [unreadable]..
  3. Computational and Functional Analysis of Gene Networks
    MARC HALFON; Fiscal Year: 2006
    ..abstract_text> ..
  4. Genetic Transfer in the Evolution of Infectious Disease
    Rob DeSalle; Fiscal Year: 2005
    ....
  5. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..