numb

Summary

Gene Symbol: numb
Description: CG3779 gene product from transcript CG3779-RB
Alias: CG3779, Dmel\CG3779, N7-1, Numb, d-numb, dNumb, l(2)03235, l(2)3235, l(2)s2201, numbs, CG3779 gene product from transcript CG3779-RB, CG3779-PA, CG3779-PB, CG3779-PD, d-Numb, numb-PA, numb-PB, numb-PD
Species: fruit fly

Top Publications

  1. ncbi Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
    Emmanuel Caussinus
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Genet 37:1125-9. 2005
  2. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
  3. ncbi Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system
    Gregory Emery
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 122:763-73. 2005
  4. ncbi Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and Sanpodo in Drosophila sensory-organ precursor cells
    Johanna Langevin
    Institut Curie, Unite Mixte de Recherche 144, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Biol 15:955-62. 2005
  5. ncbi Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Dev Biol 276:367-77. 2004
  6. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
  7. doi AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors
    Najate Benhra
    CNRS UMR 6061 Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 2 avenue du Professeur Bernard, 35000 Rennes, France
    Curr Biol 21:87-95. 2011
  8. ncbi prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 67:941-53. 1991
  9. pmc Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions
    A Burcu Babaoglan
    Program in Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 136:4089-98. 2009
  10. ncbi Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Development 126:2083-92. 1999

Research Grants

  1. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
  2. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
  3. NOTCH SIGNALING IN HEMATOPOIETIC CELLS
    THOMAS KADESCH; Fiscal Year: 2002
  4. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
  5. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
  6. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
  7. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
  8. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
  9. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
  10. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
    Emmanuel Caussinus
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Genet 37:1125-9. 2005
    ..We found that larval brain tissue carrying neuroblasts with mutations in raps (also called pins), mira, numb or pros grew to more than 100 times their initial size, invading other tissues and killing the hosts in 2 weeks...
  2. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
    ..Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila...
  3. ncbi Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system
    Gregory Emery
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 122:763-73. 2005
    ..During SOP division, the determinants Numb and Neuralized segregate into the pIIb daughter cell and establish a distinct cell fate by regulating Notch/Delta ..
  4. ncbi Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and Sanpodo in Drosophila sensory-organ precursor cells
    Johanna Langevin
    Institut Curie, Unite Mixte de Recherche 144, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Biol 15:955-62. 2005
    ..We show here that Lgl promotes the cortical recruitment of Partner of Numb (Pon) and regulates the asymmetric distribution of the fate determinants Numb and Neuralized during the pI cell ..
  5. ncbi Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Dev Biol 276:367-77. 2004
    ..Cell diversity is achieved by the asymmetric segregation of cell determinants, such as Numb and Neuralized (Neur), resulting in differential activation of the Notch (N) pathway...
  6. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
    ..PAN neuroblasts rely on the segregating determinants Numb and Brat to generate smaller, secondary neuroblasts that in turn give rise to ganglion mother cells (GMCs) and ..
  7. doi AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors
    Najate Benhra
    CNRS UMR 6061 Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 2 avenue du Professeur Bernard, 35000 Rennes, France
    Curr Biol 21:87-95. 2011
    ..Loss of AP-1 affects neither cell polarity nor the unequal segregation of the cell fate determinants Numb and Neuralized...
  8. ncbi prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 67:941-53. 1991
    ..prospero encodes a large nuclear protein with multiple homopolymeric amino acid stretches and is expressed in neuronal precursors early during their formation. It is probably generally required for proper neuronal differentiation...
  9. pmc Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions
    A Burcu Babaoglan
    Program in Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 136:4089-98. 2009
    ..Antagonistic interactions between the Notch pathway and the intrinsic cell-fate determinant Numb appear to regulate asymmetric divisions in flies and vertebrates...
  10. ncbi Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Development 126:2083-92. 1999
    ..Pros misexpression is sufficient for the transformation of PIIa to PIIb fate. The expression of Pros in the normal PIIb cell appears to be regulated by Notch signaling...
  11. ncbi The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision
    M T Su
    Department of Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Development 126:3241-51. 1999
    ..Epistasis experiments show that zfh-1 specifies EPC development independently of numb, the lineage gene that controls DA1 founder versus EPC cell fate...
  12. pmc Differentiation of the Drosophila serotonergic lineage depends on the regulation of Zfh-1 by Notch and Eagle
    Hyung Kook Lee
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell Neurosci 36:47-58. 2007
    ..Our observations on the regulation of Zfh-1 provide a new approach for examining the function of Zfh-1 in motor neurons and larval locomotion...
  13. pmc Pdm and Castor close successive temporal identity windows in the NB3-1 lineage
    Khoa D Tran
    Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Development 135:3491-9. 2008
    ..Our results provide a new neuroblast lineage for investigating temporal identity and reveal the importance of Pdm and Cas as timing factors that close temporal identity windows...
  14. pmc Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila
    Yingshi Ouyang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 138:2185-96. 2011
    ..Drosophila Numb protein regulates this process through its preferential segregation into the differentiating daughter cell...
  15. ncbi Asymmetric division of Drosophila neural stem cells: a basis for neural diversity
    F Matsuzaki
    CREST, Japan Science and Technology Corporation, Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba ku, 980 8575, Japan tohoku ac jp
    Curr Opin Neurobiol 10:38-44. 2000
    ..Our understanding now extends to the molecular nature of the cell polarity that underlies asymmetric divisions. This polarity is conserved among neural stem cells, epithelial cells and fertilized eggs...
  16. ncbi Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila
    Sheetal Bhalerao
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Curr Biol 15:1583-90. 2005
    During asymmetric cell division, protein determinants are segregated into one of the two daughter cells. The Numb protein acts as a segregating determinant during both mouse and Drosophila development...
  17. ncbi Nature versus nurture: asymmetric cell divisions in Drosophila bristle development
    J W Posakony
    Department of Biology, University of California, San Diego, La Jolla 92093 0322
    Cell 76:415-8. 1994
  18. ncbi Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
    M S Rhyu
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 76:477-91. 1994
    ..We determined by immunocytochemistry that numb is a membrane-associated protein which localizes asymmetrically to one-half of the predivisional SOP cell...
  19. ncbi Control of daughter cell fates during asymmetric division: interaction of Numb and Notch
    M Guo
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:27-41. 1996
    ..b>Numb, a membrane-associated protein, is asymmetrically segregated into one daughter cell during SOP division and acts as ..
  20. ncbi The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein
    C A Dye
    Department of Cell Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:1845-56. 1998
    ..phenotype is similar to that observed when Notch function is lost late in embryonic development and opposite to the numb loss-of-function phenotype. Genetic interaction studies show that sanpodo is epistatic to numb...
  21. ncbi Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila
    M Gho
    Laboratoire de Génétique du Développement de la Drosophile, URA 1857, Ecole Normale Superieure, Paris, France
    Nature 393:178-81. 1998
    ..At each division, distinct fates are conferred on sister cells by the asymmetric segregation of Numb, a negative regulator of Notch signalling...
  22. ncbi Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo
    M Park
    Department of Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Mech Dev 75:117-26. 1998
    ..the result of a fixed pattern of asymmetric cell divisions which are directed, in part, by interactions between numb, a localized intracellular-receptor protein, sanpodo (spdo), a potential tropomodulin homolog, and Notch, a ..
  23. ncbi Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila
    A C Nagel
    Institut für Genetik 240, Universitat Hohenheim, Stuttgart, Germany
    Mech Dev 94:3-12. 2000
    ..Thereby, Hairless and numb may have partly redundant activities...
  24. ncbi Regulation of notch signaling activity
    Francois Schweisguth
    CNRS UMR 8542, Ecole Normale Superieure, Paris, France
    Curr Biol 14:R129-38. 2004
    ..Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time...
  25. ncbi A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Dev Biol 269:1-17. 2004
    ..We propose that most Drosophila sensory organs are built from an archetypal lineage, and we speculate about how this stereotyped pattern of cell divisions may have been built during evolution...
  26. ncbi The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
    Ciara M Gallagher
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 11:641-53. 2006
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs...
  27. ncbi Asymmetric segregation of Numb and Prospero during cell division
    J A Knoblich
    Howard Hughes Medical Institute, University of California at San Francisco 94143 0724, USA
    Nature 377:624-7. 1995
    A cell can divide asymmetrically by specifically segregating a determinant into one of its daughter cells. The Numb protein is a candidate for such a determinant in the asymmetric cell divisions of the developing Drosophila nervous system...
  28. ncbi Asymmetric segregation of the homeodomain protein Prospero during Drosophila development
    J Hirata
    Department of Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan
    Nature 377:627-30. 1995
    ..We have identified a region in Prospero that is responsible for this event. The region shares a common motif with Numb, which also shows unequal segregation...
  29. ncbi The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3187-95. 1995
    ..Asymmetric cortical localization of prospero in neuroblasts requires entry into mitosis; it does not depend on numb function...
  30. ncbi tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS
    M Guo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143, USA
    Neuron 14:913-25. 1995
    ..ttk is expressed in support cells but not in neurons. It has been shown that numb, a membrane-associated protein asymmetrically distributed during the SOP division, confers different daughter cell ..
  31. ncbi Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3489-94. 1995
    ..We find that asymmetric localization of the numb protein autonomously controls a binary cell fate decision in the Drosophila CNS...
  32. ncbi Numb diverts notch pathway off the tramtrack
    J A Campos-Ortega
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Neuron 17:1-4. 1996
  33. ncbi Role of inscuteable in orienting asymmetric cell divisions in Drosophila
    R Kraut
    Institute of Molecular and Cell Biology, National University of Singapore
    Nature 383:50-5. 1996
    ..cells in the procephalic neurogenic region divide perpendicular to the surface, and segregate the proteins Numb and Prospero into the basal daughter cell...
  34. pmc The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
    E Frise
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Proc Natl Acad Sci U S A 93:11925-32. 1996
    ..fates in the Drosophila external sense organ lineage requires asymmetric localization of the intrinsic determinant Numb as well as cell-cell interactions mediated by the Delta ligand and Notch receptor...
  35. ncbi Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila
    C P Shen
    Howard Hughes Medical Institute and Department of Physiology, University of California at San Francisco, 94143 0724, USA
    Cell 90:449-58. 1997
    ..sensory organ precursor cells, and cells in the procephalic neurogenic region involves the segregation of Numb and Prospero proteins into one of the two daughter cells...
  36. pmc The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization
    J A Knoblich
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Proc Natl Acad Sci U S A 94:13005-10. 1997
    Drosophila Numb is a membrane associated protein of 557 amino acids (aa) that localizes asymmetrically into a cortical crescent in mitotic neural precursor cells and segregates into one of the daughter cells, where it is required for ..
  37. ncbi Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions
    H Ikeshima-Kataoka
    Department of Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan
    Nature 390:625-9. 1997
    ..miranda thus creates intrinsic differences between sibling cells by mediating the asymmetric segregation of a transcription factor into only one daughter cell during neural stem-cell division...
  38. ncbi Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless
    S Wang
    Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco 94143 0724, USA
    Development 124:4435-46. 1997
    ..Shortly after, the IIb cell divides to generate the neuron and the sheath cell. The membrane-associated protein Numb has been shown to be required for the first two asymmetric divisions...
  39. ncbi Segregation of myogenic lineages in Drosophila requires numb
    M Ruiz Gomez
    Department of Zoology, Cambridge, UK
    Development 124:4857-66. 1997
    ..These differences depend on an asymmetric segregation of Numb between sibling cells...
  40. pmc Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis
    A Carmena
    Centro de Biologia Molecular Severo Ochoa, C S I C Universidad Autonoma, 28049 Madrid, Spain
    Genes Dev 12:304-15. 1998
    ..Our results show that Inscuteable and Numb proteins are localized as cortical crescents on opposite sides of dividing progenitor cells...
  41. ncbi Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis
    L Yaich
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:10381-8. 1998
    The Numb protein is involved in cell fate determination during Drosophila neural development. Numb has a protein domain homologous to the phosphotyrosine-binding domain (PTB) in the adaptor protein Shc...
  42. ncbi Asymmetric cell division
    Y N Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143 0725, USA
    Nature 392:775-8. 1998
    ....
  43. pmc Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells
    M Buescher
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Genes Dev 12:1858-70. 1998
    ..of sibling neurons is accomplished through the interplay of Notch (N) signaling and the intrinsic fate determinant Numb. We show that GMCs have apical-basal polarity and Numb localization and the orientation of division are coordinated ..
  44. ncbi Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors
    B Lu
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0725, USA
    Cell 95:225-35. 1998
    During mitosis of multiple types of precursor cells in Drosophila, Numb is asymmetrically distributed between the two daughter cells and confers distinct daughter cell fates...
  45. ncbi Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity
    S C Li
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Nat Struct Biol 5:1075-83. 1998
    The phosphotyrosine-binding (PTB) domain of Numb, a protein involved in asymmetric cell division, has recently been shown to bind to the adapter protein Lnx through an LDNPAY sequence, to the Numb-associated kinase (Nak) through a ..
  46. ncbi Asymmetric cell division: from A to Z
    N Hawkins
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3204, USA
    Genes Dev 12:3625-38. 1998
  47. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  48. ncbi Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell
    M Gho
    Ecole Normale Superieure, ATIPE URA1857, 75005 Paris, France
    Development 126:3573-84. 1999
    ..Both Numb and Prospero segregated specifically into the basal glial and neuronal cells during the pIIb and pIIIb divisions, ..
  49. ncbi Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts
    M Schober
    Research Institute of Molecular Pathology, Vienna, Austria
    Nature 402:548-51. 1999
    ..Several proteins, including Numb and Miranda, segregate into the basal daughter cell and are needed for the determination of its correct cell fate...
  50. ncbi Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
    F Yu
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Cell 100:399-409. 2000
    ....
  51. ncbi A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila
    M Schaefer
    Research Institute of Molecular Pathology IMP, Vienna, A 1030, Austria
    Curr Biol 10:353-62. 2000
    ..both the apical-basal orientation of the mitotic spindle and the basal localisation of the protein determinants Numb and Prospero during mitosis...
  52. ncbi Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast
    T Ohshiro
    CREST, Japan Science and Technology Corporation, Sendai
    Nature 408:593-6. 2000
    ..At mitosis, neural fate determinants, including Prospero and Numb, localize to the basal cortex, from which the ganglion mother cell buds off; Inscuteable and Bazooka, which ..
  53. ncbi Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division
    Y Bellaiche
    Ecole Normale Superieure, UMR 8544, 46, rue d Ulm, 75230 Paris Cedex 05, France
    Nat Cell Biol 3:50-7. 2001
    ..The anterior pIIb cell specifically inherits the determinant Numb and the adaptor protein Partner of Numb (Pon)...
  54. ncbi Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage
    F Roegiers
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, California 94143 0725, USA
    Nat Cell Biol 3:58-67. 2001
    ..On the basis of these observations, we propose that two distinct mechanisms for controlling asymmetric cell divisions occur within the same lineage in the developing peripheral nervous system in Drosophila...
  55. ncbi Spindles cotton on to junctions, APC and EB1
    M Bienz
    Nat Cell Biol 3:E67-8. 2001
  56. pmc Inscuteable-independent apicobasally oriented asymmetric divisions in the Drosophila embryonic CNS
    Priyadarshini Rath
    Developmental Neurobiology Laboratory, Institute of Molecular and Cell Biology, Sinagapore, UK
    EMBO Rep 3:660-5. 2002
    ..We show that for MP2 divisions, asymmetric localisation and segregation of Numb and the specification of distinct dMP2 and vMP2 identities require bazooka but not inscuteable...
  57. ncbi Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals
    Michel Cayouette
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 5:1265-9. 2002
    ..There is increasing evidence that this mechanism also operates in vertebrate neural development and that Numb proteins, which function as cell-fate determinants during Drosophila development, may also function in this way in ..
  58. ncbi Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage
    Nicholas Justice
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0725, USA
    Curr Biol 13:778-83. 2003
    ..Neuroblasts that delaminate from the embryonic epithelium require lgl to promote formation of a basal Numb and Prospero crescent, which will be asymmetrically segregated to the basal daughter cell upon division to specify ..
  59. ncbi Unequal segregation of Neuralized biases Notch activation during asymmetric cell division
    Roland Le Borgne
    Departement de Biologie, Ecole Normale Superieure, CNRS UMR 8542, 46, rue d Ulm 75230, Cedex, Paris, France
    Dev Cell 5:139-48. 2003
    ..asymmetrically in the dividing pI cell and unequally segregates into the pIIb cell, like the Notch inhibitor Numb. Furthermore, Neuralized upregulates endocytosis of the Notch ligand Delta in the pIIb cell and acts in the pIIb ..
  60. ncbi The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila
    Martha J Lundell
    Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Development 130:4109-21. 2003
    ..In this paper, we examine the role of Numb/Notch signaling in the development of the serotonin lineage of Drosophila and show that it is necessary for ..
  61. ncbi Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila
    Kate M O'Connor-Giles
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Cell 5:231-43. 2003
    ..One such mechanism is the asymmetric localization of Numb to ensure that sibling cells respond differently to the extrinsic Notch signal and, thus, adopt distinct fates (A ..
  62. ncbi A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division
    Hanjuan Qin
    Department of Biochemistry and Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 279:11304-12. 2004
    b>Numb, an evolutionarily conserved cell fate-determining factor, plays a pivotal role in the development of Drosophila and vertebrate nervous systems...
  63. pmc The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling
    Christian A Smith
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Mol Biol Cell 15:3698-708. 2004
    The adaptor protein Numb is necessary for the cell fate specification of progenitor cells in the Drosophila nervous system...
  64. pmc Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons
    Rachel L Griffiths
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
    EMBO J 23:2440-50. 2004
    ..This enables prospero-expressing cells alone to divide further upon elimination of neurons and to adjust glial number to axons during development...
  65. ncbi Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates
    Jörg Betschinger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 14:R674-85. 2004
    ..Here, we outline the steps and factors that are involved in this process in Drosophila and C. elegans and discuss their potential conservation in vertebrates...
  66. pmc Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs
    Fabrice Roegiers
    Howard Hughes Medical Institute and Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, CA 94143 0725, USA
    Mol Biol Cell 16:3480-7. 2005
    ..of neural precursors of the central and peripheral nervous system (PNS), where a membrane-associated protein, Numb, is asymmetrically localized during cell division and is segregated to one of the two daughter cells (the pIIb cell)..
  67. pmc Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs
    Andrea Hutterer
    Institute of Molecular Biotechnology, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    EMBO Rep 6:836-42. 2005
    During asymmetric cell division in Drosophila sensory organ precursors (SOPs), the Numb protein segregates into one of the two daughter cells, in which it inhibits Notch signalling to specify pIIb cell fate...
  68. ncbi Quantitative analysis of protein dynamics during asymmetric cell division
    Bernd Mayer
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Curr Biol 15:1847-54. 2005
    In dividing Drosophila sensory organ precursor (SOP) cells, the fate determinant Numb and its associated adaptor protein Pon localize asymmetrically and segregate into the anterior daughter cell, where Numb influences cell fate by ..
  69. pmc The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity
    Nicole A Siddall
    Department of Anatomy and Cell Biology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Proc Natl Acad Sci U S A 103:8402-7. 2006
    ..We describe the complementary expression patterns of the murine Msi paralogues Msi1 and Msi2 during spermatogenesis, which support the idea of distinct, evolutionarily conserved roles of Msi...
  70. ncbi The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Dev Cell 10:731-42. 2006
    ..Our data suggest a model in which asymmetrically localized Pins-G alphai complexes regulate spindle orientation by directly binding to Mud...
  71. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
    ..b>Numb, which also acts as a tumor suppressor in larval brains, is a major downstream target of AurA and aPKC...
  72. pmc Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Genes Dev 20:3464-74. 2006
    ..This phenotype is due to two independent neuroblast defects: abnormal atypical protein kinase C (aPKC)/Numb cortical polarity and failure to align the mitotic spindle with the cortical polarity axis...
  73. pmc aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb
    Christian A Smith
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    EMBO J 26:468-80. 2007
    ..protein kinase C (aPKC) directs the polarized distribution and unequal segregation of the cell fate determinant Numb during asymmetric cell divisions...
  74. pmc Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Nature 449:96-100. 2007
    ..b>Numb is one such factor that is segregated to the differentiating daughter cell during the stem-cell-like neuroblast ..
  75. pmc Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
    Frederik Wirtz-Peitz
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell 135:161-73. 2008
    Drosophila neural precursor cells divide asymmetrically by segregating the Numb protein into one of the two daughter cells. Numb is uniformly cortical in interphase but assumes a polarized localization in mitosis...
  76. pmc S-phase favours notch cell responsiveness in the Drosophila bristle lineage
    Sylvie Remaud
    Universite Pierre et Marie Curie, UMR 7622, Paris, France
    PLoS ONE 3:e3646. 2008
    ..We suggest that high-order chromatin structures associated with the S-phase create favourable conditions that increase the efficiency of the transcriptional machinery with respect to N-target genes...
  77. pmc The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors
    Akhila Rajan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 11:815-24. 2009
    ..Our data indicate that WASp-dependent Arp2/3 actin polymerization is crucial for apical presentation of Delta, providing a mechanistic link between actin polymerization and Notch signalling...
  78. pmc Notch and Prospero repress proliferation following cyclin E overexpression in the Drosophila bristle lineage
    Françoise Simon
    Universite Pierre et Marie Curie Paris 6, UMR 7622, Paris, France
    PLoS Genet 5:e1000594. 2009
    ..Our results demonstrate that the terminal quiescent state and differentiation are regulated by two parallel mechanisms acting simultaneously on fate acquisition and cell cycle progression...
  79. pmc dbx mediates neuronal specification and differentiation through cross-repressive, lineage-specific interactions with eve and hb9
    Haluk Lacin
    Program in Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 136:3257-66. 2009
    ..of dbx and eve, or dbx and hb9, within pairs of sibling neurons is initially established as a result of Notch/Numb-mediated asymmetric divisions...
  80. doi dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila
    Mo Weng
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    Dev Cell 18:126-35. 2010
    ..We conclude that Erm dependence functionally distinguishes intermediate neural progenitors from neuroblasts in the Drosophila larval brain, balancing neurogenesis with stem cell maintenance...
  81. doi Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development
    Wei Wang
    School of Life Sciences, Tsinghua University, Beijing, China
    Dev Biol 350:414-28. 2011
    ..promotes neuroepithelial cell expansion while suppressing medulla neuroblast formation and neurogenesis; numb loss of function mimics Notch overactivation, suggesting that Numb may inhibit Notch signaling activity in the ..
  82. ncbi numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
    T Uemura
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724
    Cell 58:349-60. 1989
    ..This cell lineage is affected in numb mutants...
  83. ncbi Numb antagonizes Notch signaling to specify sibling neuron cell fates
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 17:21-6. 1996
    ..Delta-Notch signaling is required to specify vMP2 fate, whereas the localized determinant Numb is segregated into dMP2 and is required to specify dMP2 fate...
  84. ncbi Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS
    J B Skeath
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana, Illinois 61801, USA
    Development 125:1857-65. 1998
    ..Loss of Notch signaling gives the same phenotype, whereas loss of numb gives the opposite phenotype ('A/A')...
  85. ncbi Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons
    Michael E Rothenberg
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuron 39:779-91. 2003
    ..Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance...
  86. ncbi Calmodulin transcription is limited to the nervous system during Drosophila embryogenesis
    G E Kovalick
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005
    Dev Biol 150:33-46. 1992
    ..expression in embryos homozygous for mutations in four loci which are known to affect nervous system development: numb, the achaete-scute complex, daughterless, and mastermind...
  87. pmc Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo
    C T Chien
    Howard Hughes Medical Institute and Department of Physiology and Biochemistry, University of California at San Francisco, 94143 0724, USA
    Mol Cell Biol 18:598-607. 1998
    During asymmetric cell division, the membrane-associated Numb protein localizes to a crescent in the mitotic progenitor and is segregated predominantly to one of the two daughter cells...
  88. ncbi Asymmetric cell division: lessons from flies and worms
    B Lu
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0725, USA
    Curr Opin Genet Dev 8:392-9. 1998
    ..elegans and Frizzled signaling in Drosophila reveals additional mechanisms for modulating cellular polarity and suggests that there are some similarities between the two systems...
  89. pmc Genes regulating dendritic outgrowth, branching, and routing in Drosophila
    F B Gao
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, California 94143 0725, USA
    Genes Dev 13:2549-61. 1999
    ..These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis...
  90. pmc Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb
    C Zwahlen
    Structural Biology and Biochemistry Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8
    EMBO J 19:1505-15. 2000
    The phosphotyrosine-binding (PTB) domain of the cell fate determinant Numb is involved in the formation of multiple protein complexes in vivo and can bind a diverse array of peptide sequences in vitro...
  91. pmc Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling
    S Ben-Yaacov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 152:1-13. 2001
    ..The asymmetric segregation of key elements such as Numb is unaffected during this division, despite the misassignment of cell fates...
  92. ncbi Notch signaling represses the glial fate in fly PNS
    V Van De Bor
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS IGBMC ULP INSERM BP 163 67404 ILLKIRCH, C U de Strasbourg, France
    Development 128:1381-90. 2001
    ..Moreover, Notch represses neurogenesis or gliogenesis, depending on the sensory organ type. Numb, which is asymmetrically localized in the multipotent cell that produces the glial precursor, induces glial cells ..
  93. ncbi The COE--Collier/Olf1/EBF--transcription factors: structural conservation and diversity of developmental functions
    L Dubois
    Centre de Biologie du Developpement, UMR 5547, CNRS Université Paul Sabatier, 118 route de Narbonne 31062 Toulouse cedex 04, France
    Mech Dev 108:3-12. 2001
    ..We also discuss the existence of an evolutionarily conserved pathway linking Notch signalling and COE regulatory functions in various developmental decisions...
  94. ncbi Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS
    B Mehta
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 128:3161-8. 2001
    ..These results tie a cell-non-autonomous signaling pathway to the asymmetric division of precursor cells during neurogenesis...
  95. ncbi Dcas is required for importin-alpha3 nuclear export and mechano-sensory organ cell fate specification in Drosophila
    Hildegard Tekotte
    Wellcome Trust Centre for Cell Biology, ICMB, King s Buildings, University of Edinburgh, Edinburgh, Scotland, EH9 3JR, UK
    Dev Biol 244:396-406. 2002
    ..We propose that mutations in house keeping genes often cause specific developmental phenotypes, such as those observed in many human genetic disorders...
  96. ncbi Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis
    Daniela Berdnik
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:640-7. 2002
    During asymmetric cell division in the Drosophila nervous system, Numb segregates into one of two daughter cells where it is required for the establishment of the correct cell fate...
  97. ncbi Context-dependent utilization of Notch activity in Drosophila glial determination
    Yoshihiko Umesono
    Division of Developmental Genetics, National Institute of Genetics, Department of Genetics, Graduate University for Advanced Studies, Mishima, 411 8540, Japan
    Development 129:2391-9. 2002
    ..We present evidence that POU-domain protein Nubbin/PDM-1 is one of the factors that provide such context...
  98. ncbi Axon guidance: Comm hither, Robo
    Jessica Couch
    Department of Biology, 071 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Curr Biol 12:R741-2. 2002
    ..Recent studies have shed new light on the mechanism by which commissural axons change their sensitivity to guidance cues after crossing the midline...
  99. ncbi The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila
    Yohanns Bellaiche
    Ecole Normale Superieure, UMR 8542, 46, rue d Ulm, 75230 Paris, Cedex 05, France
    Development 131:469-78. 2004
    ..We propose that the Stbm-dependent recruitment of Pins at the anterior cortex of the pI cell is a novel read-out of planar cell polarity...
  100. pmc Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila
    Vladimir L Katanaev
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, Suite 1120, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:6524-9. 2006
    ..In Drosophila sensory organ precursor cells, the localization of Numb protein to the cell's anterior cortex is a key patterning event and is achieved by the combined action of many ..
  101. pmc Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal
    Chiswili Chabu
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Dev Biol 330:399-405. 2009
    ..We conclude that Twins/PP2A is required to maintain aPKC at the apical cortex of mitotic neuroblasts, keeping it out of the differentiating GMC, and thereby maintaining neuroblast homeostasis...

Research Grants13

  1. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  2. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  3. NOTCH SIGNALING IN HEMATOPOIETIC CELLS
    THOMAS KADESCH; Fiscal Year: 2002
    ..Experiments are proposed to characterize signaling through Deltex. ..
  4. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
    ..This work will provide insight into the role of these proteins in neurodegenerative diseases and development. ..
  5. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  6. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  7. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
    ..by dividing asymmetrically to produce a daughter progenitor cell and a neuron and that in such divisions, mammalian Numb proteins, m- Numb and Numblike (Numbl), asymmetrically segregate to the progenitor daughter to promote its fate...
  8. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  9. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  10. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  11. TRANSCRIPTIONAL DETERMINANTS OF B LYMPHOCYTES
    THOMAS KADESCH; Fiscal Year: 2002
    ....
  12. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  13. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..