Pc

Summary

Gene Symbol: Pc
Description: Polycomb
Alias: CG32443, CG7618, DmPc, Dmel\CG32443, Pc-G, PcG, dPC, CG32443 gene product from transcript CG32443-RA, CG32443-PA, Pc-PA, polycomb
Species: fruit fly

Top Publications

  1. pmc Alternative epigenetic chromatin states of polycomb target genes
    Yuri B Schwartz
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
    PLoS Genet 6:e1000805. 2010
  2. doi Essential role of the glycosyltransferase sxc/Ogt in polycomb repression
    Maria Cristina Gambetta
    Gene Expression Programme, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Science 325:93-6. 2009
  3. pmc CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing
    Feng Tie
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 136:3131-41. 2009
  4. ncbi A gene complex controlling segmentation in Drosophila
    E B Lewis
    Nature 276:565-70. 1978
  5. ncbi Hierarchical recruitment of polycomb group silencing complexes
    Liangjun Wang
    Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
    Mol Cell 14:637-46. 2004
  6. pmc The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain
    S E Celniker
    Division of Biology, California Institute of Technology, Pasadena 91125
    EMBO J 9:4277-86. 1990
  7. ncbi Polycomb silencing blocks transcription initiation
    Gaetano I Dellino
    Department of Zoology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva, Switzerland
    Mol Cell 13:887-93. 2004
  8. ncbi Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes
    I F Zhimulev
    Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk 630090, Russia
    Chromosoma 111:377-98. 2003
  9. pmc A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling
    Anne Kathrin Classen
    Department of Molecular and Cellular Biology, University of California, Berkeley, California, USA
    Nat Genet 41:1150-5. 2009
  10. ncbi Stabilization of chromatin structure by PRC1, a Polycomb complex
    Z Shao
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Cell 98:37-46. 1999

Patents

  1. HUMANIZED ANTIBODIES TO Fc RECEPTORS FOR IMMUNOGLOBULIN G ON HUMAN MONONUCLEAR PHAGOCYTES

Detail Information

Publications172 found, 100 shown here

  1. pmc Alternative epigenetic chromatin states of polycomb target genes
    Yuri B Schwartz
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
    PLoS Genet 6:e1000805. 2010
    b>Polycomb (PcG) regulation has been thought to produce stable long-term gene silencing. Genomic analyses in Drosophila and mammals, however, have shown that it targets many genes, which can switch state during development...
  2. doi Essential role of the glycosyltransferase sxc/Ogt in polycomb repression
    Maria Cristina Gambetta
    Gene Expression Programme, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Science 325:93-6. 2009
    b>Polycomb group proteins are conserved transcriptional repressors that control animal and plant development...
  3. pmc CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing
    Feng Tie
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 136:3131-41. 2009
    Trimethylation of histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) is essential for transcriptional silencing of Polycomb target genes, whereas acetylation of H3K27 (H3K27ac) has recently been shown to be associated ..
  4. ncbi A gene complex controlling segmentation in Drosophila
    E B Lewis
    Nature 276:565-70. 1978
    ..of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repressor of the complex...
  5. ncbi Hierarchical recruitment of polycomb group silencing complexes
    Liangjun Wang
    Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
    Mol Cell 14:637-46. 2004
    b>Polycomb group (PcG) proteins maintain the transcriptional silence of target genes through many cycles of cell division...
  6. pmc The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain
    S E Celniker
    Division of Biology, California Institute of Technology, Pasadena 91125
    EMBO J 9:4277-86. 1990
    ..gain-of-function mutants Miscadastral pigmentation (Mcp) and Superabdominal (Sab), and (iii) a trans-regulator, Polycomb (Pc)...
  7. ncbi Polycomb silencing blocks transcription initiation
    Gaetano I Dellino
    Department of Zoology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva, Switzerland
    Mol Cell 13:887-93. 2004
    b>Polycomb (PcG) complexes maintain the silent state of target genes. The mechanism of silencing is not known but has been inferred to involve chromatin packaging to block the access of transcription factors...
  8. ncbi Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes
    I F Zhimulev
    Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk 630090, Russia
    Chromosoma 111:377-98. 2003
    ..In the 4xSuUR(+) strain, 60% of the weak points coincide with the localization of Polycomb group (PcG) proteins...
  9. pmc A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling
    Anne Kathrin Classen
    Department of Molecular and Cellular Biology, University of California, Berkeley, California, USA
    Nat Genet 41:1150-5. 2009
    A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity by repressing differentiation genes, and abundant evidence points to an oncogenic role for PcG proteins in human cancer...
  10. ncbi Stabilization of chromatin structure by PRC1, a Polycomb complex
    Z Shao
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Cell 98:37-46. 1999
    The Polycomb group (PcG) genes are required for maintenance of homeotic gene repression during development. Mutations in these genes can be suppressed by mutations in genes of the SWI/SNF family...
  11. pmc Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27
    Jinrong Min
    W M Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 17:1823-8. 2003
    The chromodomain of Drosophila Polycomb protein is essential for maintaining the silencing state of homeotic genes during development...
  12. pmc Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function
    Ian F G King
    Massachusetts General Hospital, Dept of Molecular Biology, Welman 10, 50 Blossom St, Boston, MA 02114, USA
    Mol Cell Biol 25:6578-91. 2005
    b>Polycomb group (PcG) genes propagate patterns of transcriptional repression throughout development...
  13. ncbi Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products
    J Simon
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Dev Biol 158:131-44. 1993
    The Polycomb (Pc) group genes encode repressors that restrict expression of homeotic genes to precise domains along the anterior-posterior (A-P) axis...
  14. ncbi Genetic interactions and dosage effects of Polycomb group genes of Drosophila
    R B Campbell
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Mol Gen Genet 246:291-300. 1995
    The Polycomb (Pc) group of genes are required for maintenance of cell determination in Drosophila melanogaster...
  15. ncbi Recruitment of components of Polycomb Group chromatin complexes in Drosophila
    S Poux
    Department of Zoology, University of Geneva, CH1211 Geneva, Switzerland
    Development 128:75-85. 2001
    b>Polycomb Group complexes assemble at polycomb response elements (PREs) in vivo and silence genes in the surrounding chromatin...
  16. ncbi Zeste maintains repression of Ubx transgenes: support for a new model of Polycomb repression
    Man Wook Hur
    Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 134 Shinchon dong, Seodaemoon ku, Seoul, Korea 120 752
    Development 129:1339-43. 2002
    ..the expression domains of homeotic genes are maintained by two groups of ubiquitously expressed regulators: the Polycomb repressors and the Trithorax activators...
  17. pmc Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins
    Bernadett Papp
    European Molecular Biology Laboratory, Gene Expression Programme, Heidelberg, Germany
    Genes Dev 20:2041-54. 2006
    b>Polycomb group (PcG) and trithorax group (trxG) proteins act as antagonistic regulators to maintain transcriptional OFF and ON states of HOX and other target genes...
  18. ncbi Function of the Polycomb protein is conserved in mice and flies
    J Muller
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 121:2847-52. 1995
    ..In Drosophila, in those groups of cells where particular selector genes must remain inactive, it is the Polycomb-Group of genes that keep them silenced...
  19. ncbi The Drosophila homeotic gene moira regulates expression of engrailed and HOM genes in imaginal tissues
    B J Brizuela
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mech Dev 65:209-20. 1997
    ..The abnormalities caused by the loss of moira function in germ cells suggests that at least one other target gene requires moira for normal oogenesis...
  20. ncbi The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
    Ru Cao
    Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599 7295, USA
    Curr Opin Genet Dev 14:155-64. 2004
    b>Polycomb group (PcG) proteins are important for maintaining the silenced state of homeotic genes...
  21. ncbi The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II
    Shrividhya Srinivasan
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Development 132:1623-35. 2005
    The Drosophila trithorax group gene kismet (kis) was identified in a screen for extragenic suppressors of Polycomb (Pc) and subsequently shown to play important roles in both segmentation and the determination of body segment identities...
  22. ncbi The ABC of the BX-C: the bithorax complex explained
    Robert K Maeda
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Development 133:1413-22. 2006
    ..This primer attempts to distill and explain our current knowledge about this classic, complex locus...
  23. doi Drosophila Polycomb complexes restrict neuroblast competence to generate motoneurons
    Johnny J Touma
    School of Natural Sciences, University of California Merced, CA 95343, USA
    Development 139:657-66. 2012
    ..We have found that Polycomb repressor complexes (PRCs) are necessary and sufficient to restrict competence in NB7-1...
  24. ncbi Molecular mechanisms of determination in Drosophila
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Cell Biol 4:955-61. 1992
    ..Interactions between these proteins and their target selector genes are beginning to be understood, shaping our molecular view as to how stable determination of cells is achieved...
  25. ncbi Gene inactivation in Drosophila mediated by the Polycomb gene product or by position-effect variegation does not involve major changes in the accessibility of the chromatin fibre
    J Schlossherr
    Institut fur Genetik, Universitat Koln, Germany
    Mol Gen Genet 243:453-62. 1994
    In Drosophila position effect variegation and Polycomb-dependent regulation of homeotic gene expression are phenomena in which genes are inactivated in a clonally inherited manner...
  26. ncbi brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064
    Cell 68:561-72. 1992
    ..Loss-of-function brm mutations suppress mutations in Polycomb, a repressor of homeotic genes, and cause developmental defects similar to those arising from insufficient ..
  27. pmc The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila
    R Paro
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:263-7. 1991
    The Polycomb (Pc) gene of Drosophila melanogaster is a member of a large class of genes (Pc group) required for the segment-specific repression of homeotic selector genes...
  28. pmc Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster
    I M Duncan
    Genetics 102:49-70. 1982
    ..Since the wild-type allele of another gene, called Polycomb (Pc), has previously been shown to have many of the same properties as Pcl+, it appears that the BX-C and perhaps ..
  29. ncbi The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein
    E C Martin
    Biology Department, University of Virginia, Charlottesville 22903
    Development 117:641-55. 1993
    The Posterior Sex Combs (Psc) gene of Drosophila has been studied at the molecular level both because it is a Polycomb group (Pc-G) gene and hence required for the maintenance of segmental determination, and because it is the Drosophila ..
  30. pmc A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression
    C S Chan
    Department of Zoology, University of Geneva, Switzerland
    EMBO J 13:2553-64. 1994
    ..Maintenance of the pattern is due to the Polycomb group of genes (Pc-G) and the trithorax group of genes (trx-G), responsible for the persistence of the active or ..
  31. pmc Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression
    H Strutt
    ZMBH, University of Heidelberg, Germany
    EMBO J 16:3621-32. 1997
    The Polycomb group and trithorax group genes of Drosophila are required for maintaining the differential expression state of developmental regulators, such as the homeotic genes, in a stable and heritable manner throughout development...
  32. ncbi Shaping animal body plans in development and evolution by modulation of Hox expression patterns
    G Gellon
    Department of Biology, Yale University, New Haven, CT, USA
    Bioessays 20:116-25. 1998
    ..for maintenance of Hox expression pattern seem more conserved among different phyla, and rely on the action of Pc and trx group genes as well as auto- and cross-regulation among Hox genes...
  33. ncbi Propagation of silencing; recruitment and repression of naive chromatin in trans by polycomb repressed chromatin
    Marc Lavigne
    Department of Molecular Biology Massachusetts General Hospital, Massachusetts 02114, USA
    Mol Cell 13:415-25. 2004
    The Polycomb group (PcG) proteins maintain stable and heritable repression of homeotic genes...
  34. ncbi HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila
    Barbara Perrini
    Fondazione Cenci Bolognetti and Dipartimento, di Genetica e Biologia Molecolare, Universita La Sapienza, 00185 Roma, Italy
    Mol Cell 15:467-76. 2004
    ..Here, we tested this model, and we found that the capping function of HP1 is due to its direct binding to telomeric DNA, while the silencing of telomeric sequences and telomere elongation is due to its interaction with H3-MeK9...
  35. ncbi Genome-wide analysis of Polycomb targets in Drosophila melanogaster
    Yuri B Schwartz
    Rutgers University, Department of Molecular Biology and Biochemistry, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nat Genet 38:700-5. 2006
    b>Polycomb group (PcG) complexes are multiprotein assemblages that bind to chromatin and establish chromatin states leading to epigenetic silencing...
  36. doi A vertebrate Polycomb response element governs segmentation of the posterior hindbrain
    Angela Sing
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Cell 138:885-97. 2009
    Chromatin remodeling by Polycomb group (PcG) and trithorax group (trxG) proteins regulates gene expression in all metazoans...
  37. pmc The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development
    A M Pattatucci
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405
    Genetics 129:443-61. 1991
    ..Finally, we have demonstrated that the extent of Scr expression is influenced by mutations at the Polycomb (Pc) locus but not by mutant alleles of the zeste (z) gene...
  38. ncbi Reconstitution of a functional core polycomb repressive complex
    N J Francis
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell 8:545-56. 2001
    The opposing actions of polycomb (PcG) and trithorax group (trxG) gene products maintain essential gene expression patterns during Drosophila development...
  39. ncbi White gene expression, repressive chromatin domains and homeotic gene regulation in Drosophila
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Bioessays 16:549-56. 1994
    ..Another type of repressive domain is established, beginning at specific sequences, by complexes of Polycomb Group proteins...
  40. ncbi General transcription factors bind promoters repressed by Polycomb group proteins
    A Breiling
    DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Nature 412:651-5. 2001
    ..The proteins of the Polycomb group (PcG) are part of such a mechanism, maintaining gene silencing...
  41. pmc pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex
    Der Hwa Huang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 115, Republic of China
    Mol Cell Biol 22:6261-71. 2002
    The Polycomb (Pc) group (Pc-G) of repressors is essential for transcriptional silencing of homeotic genes that determine the axial development of metazoan animals...
  42. pmc Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA
    Niveen M Mulholland
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genes Dev 17:2741-6. 2003
    Repression and activation of the expression of homeotic genes are maintained by proteins encoded by the Polycomb group (PcG) and trithorax group (trxG) genes...
  43. pmc Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila
    Julie M Goodliffe
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Genes Dev 19:2941-6. 2005
    ..We find that the developmental repressor Polycomb (Pc) is required for dmyc autorepression, and that this Pc-dMyc-mediated repression spreads across an 875-kb ..
  44. pmc The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complex
    Gillian E Chalkley
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 28:2920-9. 2008
    ..Genetic analysis suggested that, like BAP, PBAP also counteracts Polycomb silencing...
  45. ncbi The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb
    M DeCamillis
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genes Dev 6:223-32. 1992
    The Polycomb group (PcG) genes in Drosophila melanogaster are required for maintenance of correct spatial expression of homeotic genes, and their products are thought to form either a regulatory network or act as a multimeric complex...
  46. ncbi Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products
    J Simon
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
    Development 114:493-505. 1992
    Mutations in genes of the Polycomb (Pc) group cause abnormal segmental development due to ectopic expression of the homeotic products of the Antennapedia and bithorax complexes...
  47. pmc Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila
    D Moazed
    UCSF School of Medicine, Department of Biochemistry and Biophysics 94143
    Development 116:805-10. 1992
    ..patterns of homeotic genes depends on the function of a number of negative trans-regulators, termed the Polycomb (Pc) group of genes...
  48. pmc Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster
    B Zink
    Center of Molecular Biology, University of Heidelberg, FRG
    EMBO J 10:153-62. 1991
    The Polycomb (Pc) gene is responsible for the elaboration and maintenance of the expression pattern of the homeotic genes during development of Drosophila...
  49. pmc Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:8136-40. 1988
    Two genes known to control the determination of segmental identity in Drosophila melanogaster are polycomb and antennapedia...
  50. ncbi The role of brahma and related proteins in transcription and development
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064, USA
    Curr Opin Genet Dev 5:473-7. 1995
    The differential transcription of Drosophila homeotic genes is maintained by the Polycomb and trithorax groups of regulatory proteins, many of which are thought to modulate chromatin structure...
  51. pmc Transcriptional silencing by the Polycomb protein in Drosophila embryos
    J Muller
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 14:1209-20. 1995
    b>Polycomb group (Pc-G) proteins act to keep homeotic genes stably and heritably silenced during Drosophila development...
  52. pmc The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites
    V Chinwalla
    Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4955, USA
    EMBO J 14:2056-65. 1995
    ..Simultaneous localization of trithorax and Polycomb indicates that many of their chromosomal binding sites coincide...
  53. ncbi Early tagma-specific commitment of Drosophila CNS progenitor NB1-1
    A Prokop
    Institut für Genetik Zellbiologie, Mainz, Germany
    Development 120:2567-78. 1994
    ..Heat induction of Ubx or abd-A expression or their derepression in Polycomb mutant embryos can override thoracic determination several hours after gastrulation (stage 10/11)...
  54. pmc Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region
    J A Kassis
    Laboratory of Developmental Biology, Food and Drug Administration, Bethesda, Maryland 20892
    Genetics 136:1025-38. 1994
    ..Genes were sought which influence the function of PS sites. Mutations in some Polycomb and trithorax group genes were found to affect the eye color from some P[en] insertion sites...
  55. ncbi polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila
    M O Fauvarque
    Centre National de la Recherche Scientifique CNRS URA 1134, Universite Paris XI, Orsay, France
    Genes Dev 7:1508-20. 1993
    ..Interestingly, it is sensitive to ph and Polycomb (Pc) mutations, which are known to affect homeotic gene regulation...
  56. pmc The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger
    N Tripoulas
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 143:913-28. 1996
    ..Both of these motifs are found in the products of some trithorax group and Polycomb group genes...
  57. pmc The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex
    O Rozenblatt-Rosen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:4152-7. 1998
    ..Its Drosophila homolog trithorax (trx) is a member of the trx-Polycomb gene family, which maintains correct spatial expression of the Antennapedia and bithorax complexes during ..
  58. pmc Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis
    V Orlando
    ZMBH, University of Heidelberg, INF 282, 69120 Heidelberg, Germany
    EMBO J 17:5141-50. 1998
    ..The Polycomb group (PcG) and trithorax group (trxG) genes encode proteins involved in chromatin remodelling...
  59. ncbi Epigenetic inheritance of active chromatin after removal of the main transactivator
    G Cavalli
    Zentrum für Molekulare Biologie ZMBH, Universität of Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Science 286:955-8. 1999
    The Drosophila Polycomb and trithorax group proteins act through chromosomal elements such as Fab-7 to maintain repressed or active gene expression, respectively...
  60. ncbi polyhomeotic controls engrailed expression and the hedgehog signaling pathway in imaginal discs
    N B Randsholt
    Centre de Génétique Moléculaire du C N R S, UPR 2167, F 91198, Gif sur Yvette Cedex, France
    Mech Dev 95:89-99. 2000
    b>Polycomb group (PcG) genes maintain cell identities during development in insects and mammals and their products are required in many developmental pathways...
  61. pmc Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers
    F Bantignies
    Vollum Institute and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 20:9317-30. 2000
    ..Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure...
  62. pmc The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity
    R K Mishra
    Département de Zoologie et Biologie Animale, Universite de Geneve, 1211 Geneva 4, Switzerland
    Mol Cell Biol 21:1311-8. 2001
    In the work reported here we have undertaken a functional dissection of a Polycomb response element (PRE) from the iab-7 cis-regulatory domain of the Drosophila melanogaster bithorax complex (BX-C)...
  63. ncbi The MCP silencer of the Drosophila Abd-B gene requires both Pleiohomeotic and GAGA factor for the maintenance of repression
    A Busturia
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, CSIC UAM, Campus de Cantoblanco, Madrid 28049, Spain
    Development 128:2163-73. 2001
    Silencing of homeotic gene expression requires the function of cis-regulatory elements known as Polycomb Response Elements (PREs)...
  64. ncbi The Drosophila trithorax protein is a coactivator required to prevent re-establishment of polycomb silencing
    Sylvain Poux
    Department of Zoology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva, Switzerland
    Development 129:2483-93. 2002
    b>Polycomb group (PcG) and Trithorax (TRX) complexes assemble at Polycomb response elements (PREs) and maintain respectively the repressed and active state of homeotic genes...
  65. pmc Transvection and silencing of the Scr homeotic gene of Drosophila melanogaster
    Jeffrey W Southworth
    Section on Drosophila Gene Regulation, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2785, USA
    Genetics 161:733-46. 2002
    ..Silencing of the Scr gene in the second and third thoracic segments, which requires the Polycomb group proteins, is disrupted by most chromosomal aberrations within the Scr gene...
  66. ncbi Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1
    Christian Beisel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Nature 419:857-62. 2002
    ..Thus, histone methylation by Ash1 may provide a specific signal for the establishment of epigenetic, active transcription patterns...
  67. ncbi The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing
    J Lesley Brown
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 130:285-94. 2003
    b>Polycomb group proteins (PcG) repress homeotic genes in cells where these genes must remain inactive during Drosophila and vertebrate development...
  68. pmc Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908 0733, USA
    Genes Dev 17:1870-81. 2003
    ..Here we show that the chromodomain proteins Polycomb (Pc) and HP1 (heterochromatin protein 1) are highly discriminatory for binding to these sites in vivo and in ..
  69. pmc YY1 DNA binding and PcG recruitment requires CtBP
    Lakshmi Srinivasan
    University of Pennsylvania, School of Veterinary Medicine, Department of Animal Biology, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 18:2596-601. 2004
    We found that mammalian Polycomb group (PcG) protein YY1 can bind to Polycomb response elements in Drosophila embryos and can recruit other PcG proteins to DNA. PcG recruitment results in deacetylation and methylation of histone H3...
  70. ncbi Tissue specificity of hedgehog repression by the Polycomb group during Drosophila melanogaster development
    Grégory Chanas
    Institut de Génétique Humaine IGH CNRS UPR 1142 141 rue de la Cardonille 34396 Montpellier France
    Mech Dev 122:975-87. 2005
    ..In this article, we show that hh is maintained in a repressed state by the Polycomb group (PcG) chromatin proteins...
  71. ncbi Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs
    Nara Lee
    Centre for Molecular Biology Heidelberg ZMBH, University of Heidelberg, 69120 Heidelberg, Germany
    Nature 438:234-7. 2005
    ..b>Polycomb group (PcG) proteins maintain cellular fates by controlling the expression patterns of homeotic genes and other ..
  72. pmc Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and Pleiohomeotic
    Andras Blastyak
    Hungarian Academy of Sciences, Biological Research Center, Institute of Genetics, Temesvari krt 62, P O B 521, H 6701 Szeged, Hungary
    Mol Cell Biol 26:1434-44. 2006
    Specific targeting of the protein complexes formed by the Polycomb group of proteins is critically required to maintain the inactive state of a group of developmentally regulated genes...
  73. doi Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity
    Svetlana Petruk
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 135:2383-90. 2008
    b>Polycomb group (PcG) and trithorax group (trxG) proteins act in an epigenetic fashion to maintain active and repressive states of expression of the Hox and other target genes by altering their chromatin structure...
  74. pmc Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II
    Shrividhya Srinivasan
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA
    PLoS Genet 4:e1000217. 2008
    b>Polycomb and trithorax group proteins regulate cellular pluripotency and differentiation by maintaining hereditable states of transcription...
  75. ncbi Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster
    S Messmer
    Center for Molecular Biology ZMBH, University of Heidelberg, Germany
    Genes Dev 6:1241-54. 1992
    The chromo domain was identified as a homologous protein motif between Polycomb (Pc)--a member of the Pc-group genes encoding transcriptional repressors of the homeotic genes--and HP1--a heterochromatin-associated protein encoded by the ..
  76. pmc The ash-1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related
    A Shearn
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    Genetics 121:517-25. 1989
    ..The third test was to examine the interaction with a mutation of the Polycomb gene...
  77. ncbi In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster
    B Zink
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, FRG
    Nature 337:468-71. 1989
    ..One of the trans-regulatory genes, Polycomb (Pc), acts as a repressor of the ANT-C and BX-C...
  78. ncbi The localization and regulation of Antennapedia protein expression in Drosophila embryos
    S B Carroll
    Cell 47:113-22. 1986
    ..The distributions of the Antp and the Ultrabithorax (Ubx) proteins in doubly-labeled embryos suggest that the Ubx protein may be one direct negative regulator of Antp gene expression...
  79. pmc Homoeosis in Drosophila. I. Complementation studies with revertants of Nasobemia
    R E Denell
    Genetics 75:279-97. 1973
    ..allele; and three genes causing a transformation of second and third legs into first legs: Extra sex comb (Scx), Polycomb (Pc), and Multiple sex comb (Msc.)...
  80. ncbi Different requirements for homeotic genes in the soma and germ line of Drosophila
    P A Lawrence
    Cell 35:27-34. 1983
    ..Similarly, neither of two regulatory genes (Polycomb+ and extra sex combs+) are required for normal oogenesis...
  81. ncbi A gene product required for correct initiation of segmental determination in Drosophila
    G Struhl
    Nature 293:36-41. 1981
    ..The resulting combinations of active and inactive genes established at this time then maintain the specific pathways of development followed subsequently by the different segments...
  82. ncbi Locking in stable states of gene expression: transcriptional control during Drosophila development
    J Simon
    Department of Biochemistry, University of Minnesota, St Paul 55108, USA
    Curr Opin Cell Biol 7:376-85. 1995
    ..The Polycomb group and trithorax group proteins of Drosophila are key transcriptional regulators that maintain stable ..
  83. ncbi Imaginal disc silencers from Ultrabithorax: evidence for Polycomb response elements
    B Christen
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Mech Dev 48:255-66. 1994
    Silencers from the Drosophila homeotic gene Ultrabithorax (Ubx) require hunchback (hb) and Polycomb (Pc) to suppress the activity of embryonic enhancers outside the Ubx domain...
  84. pmc Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster
    N N Cheng
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genetics 138:1151-62. 1994
    The Polycomb (Pc) group genes of Drosophila are negative regulators of homeotic genes, but individual loci have pleiotropic phenotypes...
  85. ncbi The Polycomb gene is differentially regulated during oogenesis and embryogenesis of Drosophila melanogaster
    R Paro
    ZMBH Universität Heidelberg, Germany
    Mech Dev 40:37-46. 1993
    ..In laterstages the Polycomb-group (Pc-G) genes were found to keep homeotic genes stably repressed in those domains where they have to be ..
  86. ncbi The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2785, USA
    Annu Rev Genet 29:289-303. 1995
    The Polycomb and trithorax group genes encode trans-regulators of homeotic gene function in Drosophila...
  87. pmc Hunchback-independent silencing of late Ubx enhancers by a Polycomb Group Response Element
    S Poux
    Department of Zoology, University of Geneva, Switzerland
    EMBO J 15:4713-22. 1996
    ..are kept silent outside of their appropriate expression domains by a repressive chromatin complex formed by the Polycomb Group proteins...
  88. ncbi In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element
    J Mihaly
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Development 124:1809-20. 1997
    ..an extensive collection of new Fab-7 mutations that allow us to subdivide Fab-7 into a boundary element and a Polycomb-respond element (PRE)...
  89. ncbi Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent
    M Pal-Bhadra
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Cell 90:479-90. 1997
    ..Silencing of the Adh gene is not influenced by zeste-dependent transvection but strongly affected by the Polycomb and Polycomblike mutations...
  90. ncbi The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen
    Y Yamamoto
    Biozentrum, University of Basel, Switzerland
    Development 124:3385-94. 1997
    ..characterized the cramped (crm) gene of Drosophila melanogaster, and show that it can be classified as a Polycomb-group (Pc-G) gene...
  91. ncbi Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences
    M Pal-Bhadra
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Cell 99:35-46. 1999
    ..The silencing interaction is initiated during early development. The silenced transgenes are associated with the Polycomb group complex of chromatin proteins.
  92. pmc Structure of a polycomb response element and in vitro binding of polycomb group complexes containing GAGA factor
    B Horard
    Department of Zoology, University of Geneva, CH1211 Geneva, Switzerland
    Mol Cell Biol 20:3187-97. 2000
    b>Polycomb response elements (PREs) are regulatory sites that mediate the silencing of homeotic and other genes...
  93. ncbi Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing
    R Lupo
    DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy
    Mol Cell 7:127-36. 2001
    ..We show that Topoisomerase II (TOPOII) and Barren (BARR) interact in vivo with Polycomb group (PcG) target sequences in the bithorax complex of Drosophila, including Polycomb response elements...
  94. ncbi Polycomb group proteins and heritable silencing of Drosophila Hox genes
    D Beuchle
    Max Planck Institut fur Entwicklungsbiologie, Spemannstr 35 III, 72076 Tubingen, Germany
    Development 128:993-1004. 2001
    ..This phenomenon of heritable silencing depends on proteins of the Polycomb Group (PcG) and on cis-acting Polycomb response elements (PREs) in the Hox gene loci...
  95. pmc Essential role of Drosophila Hdac1 in homeotic gene silencing
    Y L Chang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China
    Proc Natl Acad Sci U S A 98:9730-5. 2001
    ..We show that Drosophila Hdac1, an Rpd3-type gene, interacts cooperatively with Polycomb group repressors in silencing the homeotic genes that are essential for axial patterning of body segments...
  96. pmc Polycomb group repression reduces DNA accessibility
    D P Fitzgerald
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:6585-97. 2001
    The Polycomb group proteins are responsible for long-term repression of a number of genes in Drosophila melanogaster, including the homeotic genes of the bithorax complex...
  97. ncbi Chromatin insulators and boundaries: effects on transcription and nuclear organization
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, UDA
    Annu Rev Genet 35:193-208. 2001
    ..Insulators might modulate transcription by organizing the chromatin fiber within the nucleus through the establishment of higher-order domains of chromatin structure...
  98. ncbi RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila
    Manika Pal-Bhadra
    Division of Biological Sciences, 117 Tucker Hall, University of Missouri, Columbia, MO 65211, USA
    Mol Cell 9:315-27. 2002
    ..Transcriptional gene silencing (TGS) is Polycomb dependent and occurs when Adh is driven by the white eye color gene promoter...
  99. ncbi Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    Ru Cao
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Science 298:1039-43. 2002
    b>Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX genes. Recent studies have implicated histone methylation in long-term gene silencing...
  100. pmc Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression
    Adone Mohd-Sarip
    Department of Molecular and Cell Biology, Centre for Biomedical Genetics, Leiden University Medical Center, 2300 RA Leiden, The Netherlands
    Mol Cell Biol 22:7473-83. 2002
    b>Polycomb group (PcG) proteins function through cis-acting DNA elements called PcG response elements (PREs) to stably silence developmental regulators, including the homeotic genes...
  101. pmc Native and recombinant polycomb group complexes establish a selective block to template accessibility to repress transcription in vitro
    Ian F G King
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Cell Biol 22:7919-28. 2002
    b>Polycomb group (PcG) proteins are responsible for stable repression of homeotic gene expression during Drosophila melanogaster development...

Research Grants19

  1. ALIGNMENT BASED METHODS FOR MOLECULAR SEQUENCE ANALYSIS
    Steven Henikoff; Fiscal Year: 2001
    ..This effort could yield new eukaryotic family members of great importance for understanding epigenetic phenomena, some of which, such as parental imprinting, are relevant to human disease. ..
  2. Biochemical dissection of epigenetic inheritance by Polycomb group proteins
    NICOLE JANE FRANCIS; Fiscal Year: 2010
    ..Proteins encoded by the Drosophila Polycomb Group (PcG) genes maintain key patterns of gene expression during development...
  3. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2004
    ..This will help illuminate the basic mechanisms underlying gene expression defects that occur in some human diseases. ..
  4. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 2005
    ..These studies represent parallel in vitro and in vivo approaches to study gene regulation and cellular differentiation. ..
  5. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
    ..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
  6. Genetic Control of Cardiac Cell-Type Specification
    Rolf Bodmer; Fiscal Year: 2005
    ....
  7. Long-range High-resolution Mapping of Chromatin
    Robert Kingston; Fiscal Year: 2005
    ..Aim 3 will develop bioinformatics tools to interpret the data collected in Aim 2. ..
  8. Roles of Oct4 dimers during mouse germline development
    Michael Atchison; Fiscal Year: 2006
    ..The anticipated results will have relevant applicability to stem cell and germline biology and lead to a better understanding of human reproduction. ..
  9. Maintenance of blocks-based tools for functional genomic
    Steven Henikoff; Fiscal Year: 2006
    ..These various components will be packaged to facilitate updates and local implementations. [unreadable] [unreadable]..
  10. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
    ..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. [unreadable] [unreadable] [unreadable]..
  11. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010
    ..3) We plan to determine how the polycomb group chromatin remodeling protein, M33, is involved in the establishment of ovarian or testis developmental ..
  12. Control of fat accumulation in relation to cardiac function in Drosophila
    Rolf Bodmer; Fiscal Year: 2008
    ..The outcome of these efforts is expected to provide key mechanistic insights into the complex control of fat accumulation and its influence on heart function ..
  13. Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell Lineage
    Xin Chen; Fiscal Year: 2008
    ..factors) homologs are responsible for expression of spermatid differentiation genes by counteracting the Polycomb transcription represser...
  14. PcG Function of YY1 in Transcription and Development
    Michael L Atchison; Fiscal Year: 2010
    YY1 is a developmental^ important transcription factor that regulates expression of numerous genes. The Drosophila Polycomb group (PcG) protein, Pleiohomeotic (PHO), bears sequence homology with YY1...
  15. TRANSCRIPTION FACTOR INTERACTIONS WITH NUCLEOSOMES
    Robert Kingston; Fiscal Year: 2008
    ..We will develop a tissue culture system to characterize the magnitude and spread of changes in chromatin structure caused by different remodeling activities. [unreadable] [unreadable]..
  16. Noncoding RNAs and Chromatin Structure
    Richard Kelley; Fiscal Year: 2007
    ..A new model to explain how cis spreading operates will be tested. New search methods will be developed to identify currently unknown noncoding RNAs. [unreadable] [unreadable]..
  17. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
    ..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. [unreadable] [unreadable]..
  18. CHARACTERIZATION OF POLYCOMB GROUP COMPLEXES
    Robert Kingston; Fiscal Year: 2003
    DESCRIPTION (adapted from applicant's abstract): The polycomb-group (Pc-G) genes of Drosophila are required to maintain appropriate repression of genes that regulate developmental processes...
  19. Analysis of MRG family and hTERT null phenotypes by RNAi
    Michael Bertram; Fiscal Year: 2002
    ..These experiments will lay the groundwork for further investigation into molecular and genetic interactions involving the MRG family and hTERT by providing an in vivo null system experimental system. ..

Patents1

  1. HUMANIZED ANTIBODIES TO Fc RECEPTORS FOR IMMUNOGLOBULIN G ON HUMAN MONONUCLEAR PHAGOCYTES
    Patent Number: WO9410332-A1; Date:1994-05-11