rut

Summary

Gene Symbol: rut
Description: rutabaga
Alias: Ac12F, CG9533, Dmel\CG9533, EP1603, RUT, Rut, Rut-AC, CG9533 gene product from transcript CG9533-RB, CG9533-PA, CG9533-PB, CG9533-PC, CG9533-PD, CG9533-PE, CG9533-PF, CG9533-PG, RUTABAGA, adenylyl cyclase, rut-PA, rut-PB, rut-PC, rut-PD, rut-PE, rut-PF, rut-PG, rutabage
Species: fruit fly

Top Publications

  1. ncbi Role of cAMP cascade in synaptic stability and plasticity: ultrastructural and physiological analyses of individual synaptic boutons in Drosophila memory mutants
    J J Renger
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52240, USA
    J Neurosci 20:3980-92. 2000
  2. ncbi A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster
    M J Cann
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Genes Evol 210:200-6. 2000
  3. pmc Interactions between the inositol 1,4,5-trisphosphate and cyclic AMP signaling pathways regulate larval molting in Drosophila
    K Venkatesh
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Rd, Bangalore 560065, India
    Genetics 158:309-18. 2001
  4. ncbi Mutations affecting the cAMP transduction pathway modify olfaction in Drosophila
    F Martin
    Department of Functional Biology Genetics, Facultad de Medicina Universidad de Oviedo, Spain
    J Comp Physiol A 187:359-70. 2001
  5. pmc Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch
    Zhengmei Mao
    Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:198-203. 2004
  6. ncbi A neurofibromatosis-1-regulated pathway is required for learning in Drosophila
    H F Guo
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 403:895-8. 2000
  7. pmc A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory
    Monica E Buchanan
    Department of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurosci 30:10135-43. 2010
  8. ncbi Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade
    Y Zhong
    Department of Biology, University of Iowa, Iowa City 52242
    J Neurosci 12:644-51. 1992
  9. ncbi Preferential expression of the Drosophila rutabaga gene in mushroom bodies, neural centers for learning in insects
    P L Han
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    Neuron 9:619-27. 1992
  10. ncbi Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade
    Y Zhong
    Department of Biology, University of Iowa, Iowa City 52242
    Science 251:198-201. 1991

Research Grants

  1. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
  2. NEURON DIFFERENTIATION IN C ELEGANS
    Scott Emmons; Fiscal Year: 2002
  3. GENETIC INTERFERENCE WITH MEMORY CONSOLIDATION
    Edward Korzus; Fiscal Year: 2003
  4. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
  5. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
  6. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2008
  7. How do photoreceptor axons choose appropriate post-synaptic partners?
    THOMAS ROBERT CLANDININ; Fiscal Year: 2010
  8. GENETIC ANALYSIS OF MORPHOGENESIS IN A NEMATODE
    Scott Emmons; Fiscal Year: 2005
  9. Connectivity in the Nematode Nervous System
    Scott Emmons; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. ncbi Role of cAMP cascade in synaptic stability and plasticity: ultrastructural and physiological analyses of individual synaptic boutons in Drosophila memory mutants
    J J Renger
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52240, USA
    J Neurosci 20:3980-92. 2000
    Mutations of the genes rutabaga (rut) and dunce (dnc) affect the synthesis and degradation of cAMP, respectively, and disrupt learning in Drosophila...
  2. ncbi A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster
    M J Cann
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Genes Evol 210:200-6. 2000
    We describe the cloning and characterization of a new gene family of adenylyl cyclase related genes in Drosophila. The five adenylyl cyclase-like genes that define this family are clearly distinct from previously known adenylyl cyclases...
  3. pmc Interactions between the inositol 1,4,5-trisphosphate and cyclic AMP signaling pathways regulate larval molting in Drosophila
    K Venkatesh
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Rd, Bangalore 560065, India
    Genetics 158:309-18. 2001
    ..Here we show that mutants for adenylate cyclase (rut) synergize, during larval molting, with itpr mutant alleles, indicating that both cAMP and InsP(3) signaling ..
  4. ncbi Mutations affecting the cAMP transduction pathway modify olfaction in Drosophila
    F Martin
    Department of Functional Biology Genetics, Facultad de Medicina Universidad de Oviedo, Spain
    J Comp Physiol A 187:359-70. 2001
    ..and dunce genes, encode two enzymes of the cyclic adenosine monophosphate transduction pathway in Drosophila, adenylyl cyclase and cyclic adenosine monophosphate phosphodiesterase, respectively...
  5. pmc Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch
    Zhengmei Mao
    Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:198-203. 2004
    ..This line was used to drive the expression of a rutabaga cDNA in otherwise rutabaga mutant flies...
  6. ncbi A neurofibromatosis-1-regulated pathway is required for learning in Drosophila
    H F Guo
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 403:895-8. 2000
    ..as a Ras-GAP but also as a possible regulator of the cAMP pathway that involves the rutabaga (rut)-encoded adenylyl cyclase. Because rut was isolated as a learning and short-term memory mutant, we have pursued the hypothesis that NF1 ..
  7. pmc A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory
    Monica E Buchanan
    Department of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurosci 30:10135-43. 2010
    ..the cAMP pathway, including the demonstration of a genetic interaction between Nf1 and the rutabaga-encoded adenylyl cyclase (Rut-AC)...
  8. ncbi Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade
    Y Zhong
    Department of Biology, University of Iowa, Iowa City 52242
    J Neurosci 12:644-51. 1992
    ..and potentiation are disrupted at larval neuromuscular junctions in the memory mutants dunce (dnc) and rutabaga (rut) of Drosophila...
  9. ncbi Preferential expression of the Drosophila rutabaga gene in mushroom bodies, neural centers for learning in insects
    P L Han
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    Neuron 9:619-27. 1992
    ..demonstrated that the expression of the rutabaga gene, which encodes a Ca2+/calmodulin-responsive adenylyl cyclase, is markedly elevated in the mushroom bodies of normal flies and that the insertion elements compromised its ..
  10. ncbi Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade
    Y Zhong
    Department of Biology, University of Iowa, Iowa City 52242
    Science 251:198-201. 1991
    Synaptic transmission was examined in Drosophila mutants deficient in memory function. These mutants, dunce and rutabaga, are defective in different steps of the cyclic adenosine 3',5'-monophosphate (cAMP) cascade...
  11. ncbi Adaptation and fatigue of a mechanosensory neuron in wild-type Drosophila and in memory mutants
    G Corfas
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    J Neurosci 10:491-9. 1990
    ..This sensory fatigue depends on the duration of the stimuli and the rate of stimulation. Two mutants, rutabaga (rut) and dunce (dnc), which are defective in learning and in the activity of the cAMP cascade, show altered ..
  12. pmc Rescue of the learning defect in dunce, a Drosophila learning mutant, by an allele of rutabaga, a second learning mutant
    M B Feany
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 87:2795-9. 1990
    ..Selection of mutations that suppress dunce sterility has led to the isolation of two rutabaga alleles. The alleles (rut2 and rut3) decrease basal adenylate cyclase activity [Bellen, H. J., Gregory, B. K...
  13. ncbi Classical conditioning and retention in normal and mutant Drosophila melanogaster
    T Tully
    J Comp Physiol A 157:263-77. 1985
    ..The mutants amnesiac, rutabaga and dunce showed appreciable learning acquisition, but their memories decayed very rapidly during the first 30 ..
  14. ncbi Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant
    M S Livingstone
    Cell 37:205-15. 1984
    ..The mutation possibly affects the catalytic subunit directly. We postulate that there is at least one other type of adenylate cyclase activity that is unaffected by the mutation and insensitive to calcium/calmodulin...
  15. pmc Reward learning in normal and mutant Drosophila
    B L Tempel
    Proc Natl Acad Sci U S A 80:1482-6. 1983
    ..Two other mutants, dunce and rutabaga, which were isolated because they failed to learn the shock-avoidance task, learn normally in response to sucrose ..
  16. pmc Three Drosophila mutations that block associative learning also affect habituation and sensitization
    J S Duerr
    Proc Natl Acad Sci U S A 79:3646-50. 1982
    ..The dunce, turnip, and rutabaga mutants all habituate less than normal flies...
  17. ncbi Genetic dissection of consolidated memory in Drosophila
    T Tully
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:35-47. 1994
    ..LTM showed no appreciable decay over 7 days, was sensitive to CXM, and was not disrupted by the radish mutation...
  18. ncbi The mating of a fly
    J C Hall
    Department of Biology, Brandeis University, Waltham, MA 02254 9110
    Science 264:1702-14. 1994
    ..Further behavioral mutations seemed originally to be courtship-specific, turned out not to have that property, and have led to a broadened perspective on the nature and action of Drosophila's sex-determination genes...
  19. ncbi Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies
    J S de Belle
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Universitat Wurzburg, Germany
    Science 263:692-5. 1994
    ..This deficit cannot be attributed to reductions in olfactory sensitivity, shock reactivity, or locomotor behavior. The results demonstrate that MBs mediate associative odor learning in flies...
  20. ncbi Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory
    E M Skoulakis
    Center for Learning and Memory, Cold Spring Harbor Laboratory, New York 11724
    Neuron 11:197-208. 1993
    ..suggested by the aberrant behavioral phenotypes of the mutants dunce (cAMP phosphodiesterase) and rutabaga (adenylyl cyclase)...
  21. ncbi Altered habituation of an identified escape circuit in Drosophila memory mutants
    J E Engel
    Department of Biological Sciences, University of Iowa, Iowa City 52242, USA
    J Neurosci 16:3486-99. 1996
    ..Mutations of rutabaga that diminish cAMP synthesis reduced the rate of habituation, whereas dunce mutations that increase cAMP levels ..
  22. ncbi The Drosophila brain revisited by enhancer detection
    P L Han
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurobiol 31:88-102. 1996
    ..The expression patterns produced by 12 different insertions at the rutabaga locus were found to be extremely similar in the brain and offer strong evidence that the enhancer detector ..
  23. ncbi Gene discovery in Drosophila: new insights for learning and memory
    J Dubnau
    Cold Spring Harbor Laboratory, New York 11724, USA
    Annu Rev Neurosci 21:407-44. 1998
    ..Second, because core cellular mechanisms of simple forms of learning are evolutionarily conserved, biological pathways discovered in invertebrates are likely to be conserved in vertebrate systems as well...
  24. ncbi Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway
    M S Moore
    Gallo Center and Department of Neurology, University of California, San Francisco, 94110, USA
    Cell 93:997-1007. 1998
    ..Taken together, our results provide functional evidence for the involvement of the cAMP signal transduction pathway in the behavioral response to intoxicating levels of ethanol...
  25. ncbi Decreased odor avoidance after electric shock in Drosophila mutants biases learning and memory tests
    T Preat
    Institut Alfred Fessard, Centre National de la Recherche Scientifique, 91190 Gif sur Yvette, France
    J Neurosci 18:8534-8. 1998
    The Drosophila mutants amnesiac, dunce (dnc), and rutabaga were isolated after associative conditioning tests, during which animals were trained to associate the presence of an odor with that of electric shocks (ES)...
  26. pmc Tripartite mushroom body architecture revealed by antigenic markers
    J R Crittenden
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 5:38-51. 1998
    ..to eight proteins expressed preferentially in the mushroom bodies: DAMB, DCO, DRK, FASII, LEO, OAMB, PKA RII, and RUT. Previous to this work, four axonal lobes, two projecting dorsally (alpha and alpha') and two medially (beta and ..
  27. ncbi Genetic approaches to memory storage
    M Mayford
    University of California, San Diego, Department of Neurosciences, La Jolla, CA 92093 0691, USA
    Trends Genet 15:463-70. 1999
    ..In these organisms, the effectiveness of genetic approaches in the study of memory has improved significantly in the past five years. Below we review these advances...
  28. ncbi A calcium-inhibited Drosophila adenylyl cyclase
    V Iourgenko
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1495:125-39. 2000
    Mammals possess a family of transmembrane, G-protein-responsive adenylyl cyclase isoforms (tmACs) encoded by distinct genes differing in their patterns of expression and modes of biochemical regulation...
  29. pmc Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram
    T Zars
    Theodor Boveri Institut fuer Biowissenschaften, Lehrstuhl fuer Genetik, Biozentrum Am Hubland, D97074, Wuerzburg, Germany
    Learn Mem 7:18-31. 2000
    ..We have used the Drosophila rutabaga type I Ca(2+)/CaM-dependent adenylyl cyclase (AC) gene to determine in which CNS region AC expression is sufficient for memory formation...
  30. ncbi Localization of a short-term memory in Drosophila
    T Zars
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Biozentrum Am Hubland, D97074, Wurzburg, Germany
    Science 288:672-5. 2000
    ..The rutabaga adenylyl cyclase, an enzyme that is ubiquitously expressed in the Drosophila brain and that mediates synaptic plasticity, is ..
  31. ncbi Behavioral functions of the insect mushroom bodies
    T Zars
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl für Genetik und Neurobiologie, Am Hubland, Biozentrum, D 97074, Wurzburg, Germany
    Curr Opin Neurobiol 10:790-5. 2000
    ..In addition, the mushroom bodies are necessary for context generalization in visual learning and for regulating the transition from walking to rest...
  32. ncbi Drosophila NO-dependent guanylyl cyclase is finely regulated by sequential order of coincidental signaling
    Lixing Zhang
    CNRS, Centre Européen des Sciences du Goût, 15, rue Hugues Picardet, Dijon 21000, France
    J Cell Biochem 85:392-402. 2002
    ....
  33. ncbi Extinction antagonizes olfactory memory at the subcellular level
    Martin Schwaerzel
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, Wurzburg, Germany
    Neuron 35:951-60. 2002
    ..Thus, unreinforced presentation of learned odorants antagonizes intracellularly the signaling cascade underlying memory formation...
  34. ncbi High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila
    Fred W Wolf
    Department of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 22:11035-44. 2002
    ..The effects of ethanol on locomotion are comparable in flies and mammals, suggesting that Drosophila is a suitable model system to study the underlying mechanisms...
  35. ncbi Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion
    Adrian Rothenfluh
    Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, 94143 0452, USA
    Curr Opin Neurobiol 12:639-45. 2002
    ..Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels...
  36. ncbi Mushroom body memoir: from maps to models
    Martin Heisenberg
    Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Nat Rev Neurosci 4:266-75. 2003
  37. ncbi Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila
    Martin Schwaerzel
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
    J Neurosci 23:10495-502. 2003
    ..Our results suggest that in associative conditioning, different memories are formed of the same odor under different circumstances, and that they are linked to the respective motivational systems by their specific modulatory pathways...
  38. ncbi Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
    ..The transient expression of the rutabaga-encoded adenylyl cyclase in the mushroom bodies of the adult brain was necessary and sufficient to rescue the rutabaga memory deficit, ..
  39. ncbi Cooperation between Drosophila flies in searching behavior
    S Tinette
    CNRS Centre Européen des Sciences du Goût, rue Hugues Picardet, Dijon, France
    Genes Brain Behav 3:39-50. 2004
    ..Future investigations of the neuronal signaling involved in this behavior will help us to understand the complexities of this aspect of Drosophila social behaviour...
  40. ncbi Habituation of an odorant-induced startle response in Drosophila
    W Cho
    Department of Anatomy, University of California at San Francisco, 94143 0452, USA
    Genes Brain Behav 3:127-37. 2004
    ..Finally, habituation is impaired in rutabaga, an adenylyl cyclase mutant isolated based on a defect in olfactory associative learning...
  41. ncbi Exclusive consolidated memory phases in Drosophila
    Guillaume Isabel
    Developpement, Evolution, Plasticité du Système Nerveux, CNRS, 1 Avenue de la Terrasse, 91190 Gifsur Yvette, France
    Science 304:1024-7. 2004
    ..We propose that ARM acts as a gating mechanism that ensures that LTM is formed only after repetitive and spaced training...
  42. ncbi An engram found? Evaluating the evidence from fruit flies
    Bertram Gerber
    Universitat Wurzburg, Lehrstuhl für Genetik und Neurobiologie, Biozentrum Am Hubland, D 970 74 Würzburg, Germany
    Curr Opin Neurobiol 14:737-44. 2004
    ..With regard to olfactory learning in flies, we argue that the notion of the olfactory memory trace being localized to the Kenyon cells of the mushroom bodies is a reasonable working hypothesis...
  43. ncbi Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 123:945-57. 2005
    ..DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition...
  44. ncbi Distinct memory traces for two visual features in the Drosophila brain
    Gang Liu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Nature 439:551-6. 2006
    ..These can be localized to two groups of neurons extending branches as parallel, horizontal strata in the fan-shaped body. The central location of this memory store is well suited to mediate translational invariance...
  45. pmc Roles for Drosophila mushroom body neurons in olfactory learning and memory
    David Benjamin G Akalal
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 13:659-68. 2006
    ..We expressed the rutabaga (rut)-encoded adenylyl cyclase in either the gamma or alpha/beta neurons and examined the effects on restoring olfactory associative ..
  46. ncbi Attention-like processes in Drosophila require short-term memory genes
    Bruno van Swinderen
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 315:1590-3. 2007
    ..These processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga. Attention defects in these mutants were associated with distinct optomotor effects in behavioral assays.
  47. doi Analysis of a spatial orientation memory in Drosophila
    Kirsa Neuser
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Nature 453:1244-7. 2008
    ..The S6KII signalling pathway therefore seems to be acutely required in the ring neurons for spatial orientation memory in flies...
  48. doi cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila
    Sung Tae Hong
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong Dong, Yusong gu, Daejeon, 305 701, Korea
    Nature 454:771-5. 2008
    ..Preferred temperatures were affected by the level of cAMP and PKA activity in the MBs in various PKA pathway mutants...
  49. doi Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster
    Kohei Ueno
    Department of Behavioral Sciences, Graduate School of Medicine, Gunma University, Maebashi, Japan
    Eur J Neurosci 28:1956-66. 2008
    ..2006). Because DGsalpha is a homolog of Gs, we hypothesized that the sugar receptors are coupled to adenylyl cyclase (AC) in Drosophila. The aim of this study was to identify the AC that participates in sugar perception...
  50. pmc Role of rut adenylyl cyclase in the ensemble regulation of presynaptic terminal excitability: reduced synaptic strength and precision in a Drosophila memory mutant
    Atsushi Ueda
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurogenet 23:185-99. 2009
    ..of the learning mutant rutabaga (rut) suggests a tight regulation of presynaptic terminal excitability by rut adenylyl cyclase (AC) that is responsible for Ca2+/calmodulin-dependent cAMP synthesis...
  51. pmc The GABAA receptor RDL suppresses the conditioned stimulus pathway for olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:1573-9. 2009
    ..down failed to enhance learning in animals carrying mutations in genes of the cAMP signaling pathway, such as rutabaga and NF1, suggesting that RDL works up stream of these functions in CS/US integration...
  52. doi Mutations affecting the cAMP transduction pathway disrupt the centrophobism behavior
    Sebastien Lebreton
    Bases Neurales des Comportements chez la Drosophile Laboratoire de Neurobiologie Cellulaire et Moléculaire NBCM, CNRS, Gif sur Yvette, France
    J Neurogenet 23:225-34. 2009
    ..Here, we report that disturbing this pathway by using different mutants, such as dnc, rut, PKA, or amn, lead to centrophobism defect...
  53. doi Differential roles of the fan-shaped body and the ellipsoid body in Drosophila visual pattern memory
    Yufeng Pan
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, People s Republic of China
    Learn Mem 16:289-95. 2009
    ..Localized expression of rutabaga adenylyl cyclase in either the fan-shaped body or the ellipsoid body is sufficient to rescue the memory defect of the rut(2080)..
  54. pmc Short- and long-term memory in Drosophila require cAMP signaling in distinct neuron types
    Allison L Blum
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 19:1341-50. 2009
    ..At the neuroanatomical level, however, different temporal stages of memory can engage distinct neural circuits, a notion that has not been conceptually integrated with the cellular view...
  55. pmc Writing memories with light-addressable reinforcement circuitry
    Adam Claridge-Chang
    Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Cell 139:405-15. 2009
    ..The delineation of core reinforcement circuitry is an essential first step in dissecting the neural mechanisms that compute and represent valuations, store associations, and guide actions...
  56. pmc Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway
    Seth M Tomchik
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:510-21. 2009
    ..revealed a synergistic increase in cAMP in the mushroom body lobes, which was dependent on the rutabaga adenylyl cyclase. This synergy was restricted to the axons of mushroom body neurons, and occurred only following forward ..
  57. doi Forgetting is regulated through Rac activity in Drosophila
    Yichun Shuai
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, P R China
    Cell 140:579-89. 2010
    ..This forgetting mechanism does not affect memory acquisition and is independent of Rutabaga adenylyl cyclase-mediated memory formation mechanisms...
  58. pmc Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
    Alex C Koon
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Neurosci 14:190-9. 2011
    ..Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range...
  59. pmc Plasticity of local GABAergic interneurons drives olfactory habituation
    Sudeshna Das
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    Proc Natl Acad Sci U S A 108:E646-54. 2011
    ..Both short-term (STH) and long-term (LTH) forms of olfactory habituation require function of the rutabaga-encoded adenylate cyclase in multiglomerular local interneurons (LNs) that mediate GABAergic inhibition in the ..
  60. doi Parallel processing of appetitive short- and long-term memories in Drosophila
    Severine Trannoy
    Genes and Dynamics of Memory Systems Group, Neurobiology Unit, CNRS, ESPCI, 10 rue Vauquelin, 75005 Paris, France
    Curr Biol 21:1647-53. 2011
    ..2) STM information is not transferred from γ neurons to αβ neurons for LTM formation; and (3) the adenylyl cyclase RUT, which is thought to operate as a coincidence detector between the olfactory stimulus and the sugar ..
  61. doi Gustatory habituation in Drosophila relies on rutabaga (adenylate cyclase)-dependent plasticity of GABAergic inhibitory neurons
    Pushkar Paranjpe
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    Learn Mem 19:627-35. 2012
    ..We explain why these data provide significant and independent support for a general model in which inhibitory potentiation underlies habituation in multiple neural systems and species...
  62. ncbi Signaling through Gs alpha is required for the growth and function of neuromuscular synapses in Drosophila
    William J Wolfgang
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Dev Biol 268:295-311. 2004
    ..Our results demonstrate that Gs alpha-dependent signaling plays a role in the dynamic cellular reorganization that underlies synaptic growth...
  63. ncbi Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
    James Jiayuan Tong
    Center for Molecular and Mitochondrial Medicine and Genetics with Department of Biological Chemistry, Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
    Nat Genet 39:476-85. 2007
    ..These phenotypic effects proved to be modulated by the adenylyl cyclase/cyclic AMP (cAMP)/protein kinase A pathway, not the Ras/Raf pathway. Treatment of wild-type D...
  64. pmc The AKAP Yu is required for olfactory long-term memory formation in Drosophila
    Yubing Lu
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Proc Natl Acad Sci U S A 104:13792-7. 2007
    ..These observations lead us to conclude that proper localization of PKA by Yu AKAP in MB neurons is required for the formation of LTM...
  65. ncbi Multiple memory traces for olfactory reward learning in Drosophila
    Andreas S Thum
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Neurosci 27:11132-8. 2007
    ..The adenylate cyclase protein, Rutabaga, has been shown to mediate both traces...
  66. pmc Prolonged presynaptic posttetanic cyclic GMP signaling in Drosophila motoneurons
    Dinara Shakiryanova
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 105:13610-3. 2008
    ..However, mutations that inhibit rutabaga Ca(2+)-stimulated adenylyl cyclase and dunce cAMP-specific phosphodiesterase (PDE) have no effect...
  67. ncbi The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase
    L R Levin
    Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205
    Cell 68:479-89. 1992
    Four putative adenylyl cyclase genes from Drosophila melanogaster were identified by virtue of their extensive sequence homology with mammalian cyclases...
  68. ncbi Odour avoidance learning in the larva of Drosophila melanogaster
    Sukant Khurana
    Tata Institute of Fundamental Research, National Centre for Biological Sciences, Bangalore 560 065, India
    J Biosci 34:621-31. 2009
    ..The same method of analysis when applied to learning mutants dunce, amnesiac, rutabaga and radish reveals memory deficits characteristic of the mutant strains.
  69. pmc An olfactory circuit increases the fidelity of visual behavior
    Dawnis M Chow
    Molecular, Cellular and Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 31:15035-47. 2011
    ..Together, our results implicate the MBs in a fast-acting, memory-independent olfactory modification of a visual reflex that is critical for flight control...
  70. pmc Sleep deprivation specifically impairs short-term olfactory memory in Drosophila
    Xinjian Li
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Sleep 32:1417-24. 2009
    ..Sleep is crucial to memory consolidation in humans and other animals; however, the effect of insufficient sleep on subsequent learning and memory remains largely elusive...
  71. pmc A genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity to halothane
    K S Krishnan
    Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:8632-6. 1990
    ..In the absence of anesthetics, these mutants display alterations of behavior that imply changes in the adult and the larval neuromuscular system...
  72. ncbi Abnormal activity of adenylate cyclase in the Drosophila memory mutant rutabaga
    Y Dudai
    Neurosci Lett 42:207-12. 1983
    The activity of adenylate cyclase in homogenates prepared from the Drosophila memory mutant rutabaga is lower than normal...
  73. ncbi Dissection of memory formation: from behavioral pharmacology to molecular genetics
    J DeZazzo
    Cold Spring Harbor Laboratory, Harbor, NY 11724, USA
    Trends Neurosci 18:212-8. 1995
    ..These studies support the application of reverse-genetic strategies, including the use of temporally specific agonists and antagonists, to advance the functional dissection of memory formation...
  74. ncbi Drosophila mushroom body subdomains: innate or learned representations of odor preference and sexual orientation?
    J S de Belle
    Max Planck Institut für biologische Kybernetik, Tubingen, Federal Republic of Germany
    Neuron 15:245-7. 1995
  75. ncbi Mediation of PACAP-like neuropeptide transmission by coactivation of Ras/Raf and cAMP signal transduction pathways in Drosophila
    Y Zhong
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 375:588-92. 1995
    ..The free G alpha then modulates the activity of adenylyl cyclase and phospholipase C...
  76. ncbi Progress in understanding the Drosophila dnc locus
    A Nighorn
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Comp Biochem Physiol Biochem Mol Biol 108:1-9. 1994
    ..This paper reviews the recent developments in the understanding of the structure and function of the gene identified by the first and best-characterized of these mutants, the Drosophila dunce mutant...
  77. ncbi Neuronal specificity and its development in the Drosophila wing disc and its derivatives
    J Palka
    Department of Zoology, University of Washington, Seattle 98195
    J Neurobiol 24:788-802. 1993
    ..The highly individual characteristics of certain of the sensory organs is emphasized, both in the context of their adult roles and as a challenge for future studies in developmental genetics...
  78. pmc A genetic analysis of the stoned locus and its interaction with dunce, shibire and Suppressor of stoned variants of Drosophila melanogaster
    T Z Petrovich
    Department of Genetics, University of Melbourne, Parkville, Victoria, Australia
    Genetics 133:955-65. 1993
    ....
  79. ncbi The cyclic AMP system and Drosophila learning
    R L Davis
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biochem 149:271-8. 1995
    ..The rutabaga gene encodes one type of adenylyl cyclase (AC) similar in properties to the Type I AC characterized from vertebrate brain...
  80. ncbi Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
    K J Mitchell
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley California 94720, USA
    Neuron 17:203-15. 1996
    ..Expression of either Netrin gene in all muscles also results in aberrant motor projections. Thus, Drosophila Netrins are required for the guidance of commissural axons at the midline, and of motor axons to their target muscles...
  81. ncbi Reduced growth cone motility in cultured neurons from Drosophila memory mutants with a defective cAMP cascade
    Y T Kim
    Department of Biological Sciences, University of lowa, lowa City 52242, USA
    J Neurosci 16:5593-602. 1996
    Drosophila memory mutants dunce (dnc) and rutabaga (rut) are known to have altered intracellular cAMP levels, nerve terminal growth, and plasticity of synaptic transmission...
  82. pmc Discovery of genes involved with learning and memory: an experimental synthesis of Hirschian and Benzerian perspectives
    T Tully
    Cold Spring Harbor Laboratory, NY 11724, USA
    Proc Natl Acad Sci U S A 93:13460-7. 1996
    ..In addition, more specific conclusions will be obtained from reverse-genetic experiments, in which gene disruptions are restricted in time and/or space...
  83. ncbi Drosophila learning and memory: recent progress and new approaches
    M P Belvin
    Cold Spring Harbor Laboratory, NY 11724, USA
    Bioessays 19:1083-9. 1997
    ....
  84. ncbi Integrin-mediated short-term memory in Drosophila
    M S Grotewiel
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 391:455-60. 1998
    ..We propose a model in which integrins act as dynamic regulators of synapse structure or the signalling events underlying short-term memory formation...
  85. ncbi Structure of the Drosophila DNA topoisomerase I gene and expression of messages with different lengths in the 3' untranslated region
    S D Brown
    Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Gene 211:195-203. 1998
    ..No significant heterogeneity at the 5' end of the top1 transcripts is seen. Sequence searches have revealed a number of regulatory sequences for potential translational control in the 3' untranslated region...
  86. ncbi The fruit fly: a model organism to study the genetics of alcohol abuse and addiction?
    H J Bellen
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 93:909-12. 1998
  87. ncbi Genetic lesions in Drosophila behavioural mutants
    G O Pflugfelder
    Theodor Boveri Institut Biozentrum, Lehrstuhl fur Genetik, Universität Würzburg Am Hubland, Germany
    Behav Brain Res 95:3-15. 1998
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations...
  88. ncbi The role of Ca2+/calmodulin-stimulable adenylyl cyclases as molecular coincidence detectors in memory formation
    N Mons
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 5807, Universite de Bordeaux 1, Talence, France
    Cell Mol Life Sci 55:525-33. 1999
    Evidence from systems as diverse as mollusks, insects and mammals has revealed that adenylyl cyclase, cyclic adenosine 3',5'-monophosphate (cAMP) cascade, cAMP-dependent protein kinases and their substrates are required for the cellular ..
  89. ncbi Altered outward K(+) currents in Drosophila larval neurons of memory mutants rutabaga and amnesiac
    D Yu
    Laboratory of Visual Information Processing, Department of Neurobiology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    J Neurobiol 40:158-70. 1999
    ..in amplitude by 5 mM cyclic adenosine monophosphate (cAMP) analog 8-bromo-cAMP in both Drosophila memory mutants rutabaga (rut) and amnesiac (amn) was significantly larger than that (50%) in wild type...
  90. ncbi Genes to remember
    C M Alberini
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Exp Biol 202:2887-91. 1999
    ..Here, we review the studies showing that conserved molecules and biological mechanisms are engaged in simple and complex forms of memory...
  91. ncbi Learning performance of normal and mutant Drosophila after repeated conditioning trials with discrete stimuli
    C D Beck
    Department of Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 20:2944-53. 2000
    ..Thus, the effect is short-lived. The utility of using a battery of tests, including a single short trial, two massed trials, and two spaced trials, to investigate parameters of memory formation in several mutants was demonstrated...
  92. ncbi Functional anatomy: from molecule to memory
    J Dubnau
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 11:R240-3. 2001
    ..Blockade of synaptic transmission in the amnesiac-expressing cells disrupts memory, but not learning, suggesting presynaptic and postsynaptic sites for memory formation...
  93. ncbi Synchronized neural activity in the Drosophila memory centers and its modulation by amnesiac
    P Rosay
    IBLS Division of Molecular Genetics, Anderson College Complex, University of Glasgow, G11 6NU, Scotland, Glasgow, United Kingdom
    Neuron 30:759-70. 2001
    ..It is also sensitive to pharmacological agents specific for several classes of ion channel and for acetylcholine and GABA receptors. A role in memory consolidation involving transcriptionally mediated synaptic strengthening is proposed...
  94. ncbi Molecular biology and anatomy of Drosophila olfactory associative learning
    G Roman
    Department of Molecular and Cellular Biology and Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston 77030, USA
    Bioessays 23:571-81. 2001
    ..In this review, we discuss the nature of the behavioral tasks, the molecules, and the neuronal circuits involved in olfactory learning in Drosophila...
  95. ncbi Neurobiology. Learning how a fruit fly forgets
    S Waddell
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 293:1271-2. 2001
  96. ncbi What can we teach Drosophila? What can they teach us?
    S Waddell
    Dept of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trends Genet 17:719-26. 2001
    ..Cloning of the affected genes implicated the adenylyl cyclase second-messenger system as key in learning and memory...
  97. ncbi The genetics of cognitive processes: candidate genes in humans and animals
    K I Morley
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Behav Genet 31:511-31. 2001
    ..This survey confirms that many genes are associated with cognitive variation and highlights the potential importance of animal models in the study of human cognition...
  98. ncbi Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila
    Aylin R Rodan
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    J Neurosci 22:9490-501. 2002
    ..We conclude that the regulation of ethanol-induced behaviors by PKA involves complex interactions among groups of cells that mediate either increased or reduced sensitivity to the acute intoxicating effects of ethanol...
  99. ncbi Genetic basis of male sexual behavior
    Scott W Emmons
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Neurobiol 54:93-110. 2003
    ..It can also help us to gain an appreciation of how behavior is encoded by genes and their regulatory sequences...
  100. ncbi Courtship lite: a personal history of reproductive behavioral neurogenetics in Drosophila
    Jeffrey C Hall
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurogenet 16:135-63. 2002
  101. ncbi Unconventional sex: fresh approaches to courtship learning
    Jennifer E Mehren
    Department of Biology and Volen Center for Complex Systems, Brandeis University MS008, 415 South Street, Waltham, Massachusetts 02454 9110, USA
    Curr Opin Neurobiol 14:745-50. 2004
    ..Advances in transgenic tools and developments in behavioral assays have increased the power of studying courtship learning in the fruit fly...

Research Grants9

  1. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
    ..The techniques proposed here offer a general method for turning on gene activity both spatially and temporally in Drosophila. ..
  2. NEURON DIFFERENTIATION IN C ELEGANS
    Scott Emmons; Fiscal Year: 2002
    ..3) screen for mutants (including ts alleles) in which TH::GFP expression is lost and characterize the corresponding genes molecularly. (4) identify genes involved in the axon connectivity of DA neurons. ..
  3. GENETIC INTERFERENCE WITH MEMORY CONSOLIDATION
    Edward Korzus; Fiscal Year: 2003
    ..A newly created mouse model will provide the unique approach to study memory consolidation at molecular, cellular and cognitive level. ..
  4. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
    ..of chronobiology in this model system may provide insights into the nature of certain rhythm-related disorders of humans, some of which are associated with genetic variations of Drosophila clock gene orthologs [unreadable] [unreadable]..
  5. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
    ..melanogaster ..
  6. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2008
    ..As a result, an understanding of the "logic" of how information is processed in relatively simple nervous systems can greatly inform future investigations of human cognition. ..
  7. How do photoreceptor axons choose appropriate post-synaptic partners?
    THOMAS ROBERT CLANDININ; Fiscal Year: 2010
    ..This study will examine the functions of several of these proteins during eye development, will inform our broad understanding of how these proteins normally act, and will benefit the creation of new treatment strategies. ..
  8. GENETIC ANALYSIS OF MORPHOGENESIS IN A NEMATODE
    Scott Emmons; Fiscal Year: 2005
    ..This research will contribute to understanding a fundamental aspect of animal development, and thus help towards progress in overcoming diseases that arise as a result of developmental abnormalities. ..
  9. Connectivity in the Nematode Nervous System
    Scott Emmons; Fiscal Year: 2002
    ..The preanal ganglion circuitry provides a unique opportunity to explore the development and function of a defined set of synapses during postembryonic life in a system which is not essential for survival in this hermaphroditic species. ..