sgg

Summary

Gene Symbol: sgg
Description: shaggy
Alias: CG2621, DMSGG3, DMZ3K25Z, Dm Zw3, Dmel\CG2621, Dmsgg3, EG:155E2.3, EG:BACR7C10.8, GSK, GSK-3, GSK-3B, GSK-3beta, GSK-3betaSgg, GSK3, GSK3-beta, GSK3A, GSK3Beta, GSK3beta, GSK3beta/SGG, GSK3betagr, GSKbeta, Gsk-3, Gsk-3beta, Gsk3, SGG, SGG/GSK3b, Sgg, Sgg/GSK-3b, Sgg/Zw3/GSK3, ZW-3, ZW3, Zw-3, Zw3, Zw3-sh, Zw3/GSK3, Zw3[sgg], anon-WO03040301.254, gsk3, l(1)3Ba, l(1)G0055, l(1)G0183, l(1)G0263, l(1)G0335, l(1)zw3, sgg-zw3, sgg/zw3, sgg10, sgg39, sgg46, zw-3, zw3, zw3(sgg), zw3/GSK3beta, zw3/sgg, zw3[sgg], zw[3], CG2621 gene product from transcript CG2621-RA, CG2621-PA, CG2621-PB, CG2621-PC, CG2621-PD, CG2621-PE, CG2621-PF, CG2621-PG, CG2621-PH, CG2621-PI, CG2621-PJ, CG2621-PK, CG2621-PM, CG2621-PN, CG2621-PO, CG2621-PP, CG2621-PQ, CG2621-PR, GSK-3 kinase, GSK3betagr, Shaggy/GSK-3beta, Shaggy/Glycogen synthase kinase 3, Shaggy/Zeste-white-3/Glycogen synthase kinase 3beta, Zeste-white3, Zw3 kinase, glycogen synthase Kinase-3, glycogen synthase kinase 3, glycogen synthase kinase 3Beta, glycogen synthase kinase-3beta, saggy, sgg-PA, sgg-PB, sgg-PC, sgg-PD, sgg-PE, sgg-PF, sgg-PG, sgg-PH, sgg-PI, sgg-PJ, sgg-PK, sgg-PM, sgg-PN, sgg-PO, sgg-PP, sgg-PQ, sgg-PR, shaggy-zeste white 3, shaggy/zeste-white 3, zest-white 3, zeste white 3, zeste white-3, zeste white3, zeste-white 3, zestewhite-3
Species: fruit fly

Top Publications

  1. ncbi Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
    Mary Ann Price
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Cell 108:823-35. 2002
  2. ncbi wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
    E Siegfried
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 71:1167-79. 1992
  3. ncbi Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    George R Jackson
    Neurogenetics Program, Department of Neurology, University of California Los Angeles, School of Medicine, 710 Westwood Plaza, 90095, USA
    Neuron 34:509-19. 2002
  4. pmc The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation
    Mary Packard
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Cell 111:319-30. 2002
  5. ncbi Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
    Nicholas S Tolwinski
    Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 4:407-18. 2003
  6. ncbi Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus
    M Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Science 287:1606-9. 2000
  7. ncbi Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila
    Bénédicte Franco
    Laboratoire de Génomique Fonctionnelle, Unité Propre de Recherche Centre National de la Recherche Scientifique 2580, 34094 Montpellier Cedex 5, France
    J Neurosci 24:6573-7. 2004
  8. pmc The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila
    A Gallet
    Labororatoire de Génétique et Physiologie du Développement, UMR 9943 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy Case 907, F 13288 Marseille, Cedex 09, France
    EMBO J 18:2208-17. 1999
  9. pmc Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo
    Pamela F Colosimo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 1:e9. 2006
  10. ncbi Study of tauopathies by comparing Drosophila and human tau in Drosophila
    Xinping Chen
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Tissue Res 329:169-78. 2007

Detail Information

Publications140 found, 100 shown here

  1. ncbi Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
    Mary Ann Price
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Cell 108:823-35. 2002
    ..We show that these phosphoserines prime further phosphorylation at adjacent Glycogen Synthase Kinase 3 (GSK3) and Casein Kinase I (CK1) sites...
  2. ncbi wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
    E Siegfried
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 71:1167-79. 1992
    ..Here, we report that the segment polarity gene zeste-white 3 (zw3; also known as shaggy) acts as a repressor of en autoregulation...
  3. ncbi Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    George R Jackson
    Neurogenetics Program, Department of Neurology, University of California Los Angeles, School of Medicine, 710 Westwood Plaza, 90095, USA
    Neuron 34:509-19. 2002
    ..we show that tau overexpression, in combination with phosphorylation by the Drosophila glycogen synthase kinase-3 (GSK-3) homolog and wingless pathway component (Shaggy), exacerbated neurodegeneration induced by tau overexpression ..
  4. pmc The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation
    Mary Packard
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Cell 111:319-30. 2002
    ..We suggest that Wg signals the coordinated development of pre- and postsynaptic compartments...
  5. ncbi Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
    Nicholas S Tolwinski
    Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 4:407-18. 2003
    ..The intracellular pathway bypasses Gsk3beta/Zw3, the kinase normally required for controlling beta-catenin/Armadillo levels, suggesting that modulated ..
  6. ncbi Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus
    M Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Science 287:1606-9. 2000
  7. ncbi Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila
    Bénédicte Franco
    Laboratoire de Génomique Fonctionnelle, Unité Propre de Recherche Centre National de la Recherche Scientifique 2580, 34094 Montpellier Cedex 5, France
    J Neurosci 24:6573-7. 2004
    ..We found that Shaggy (Sgg), the Drosophila homolog of the mammalian glycogen synthase kinases 3 alpha and beta, two serine-threonine kinases, ..
  8. pmc The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila
    A Gallet
    Labororatoire de Génétique et Physiologie du Développement, UMR 9943 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy Case 907, F 13288 Marseille, Cedex 09, France
    EMBO J 18:2208-17. 1999
    ..We discuss these results with respect to current models of Armadillo/beta-catenin action for the transmission of the Wingless/Wnt pathway...
  9. pmc Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo
    Pamela F Colosimo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 1:e9. 2006
    ..Our results suggest new roles for Hh and Wg as instructive polarizing cues that help establish directionality within a cell sheet, and a new polarity-signaling role for the membrane fraction of the oncoprotein Arm...
  10. ncbi Study of tauopathies by comparing Drosophila and human tau in Drosophila
    Xinping Chen
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Tissue Res 329:169-78. 2007
    ..These results suggest that the two tau genes differ significantly. This comparison between species-specific isoforms may help to clarify whether the homologous tau genes are conserved...
  11. doi Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease
    James Folwell
    Department of Neurosciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Exp Neurol 223:401-9. 2010
    ..of tau(wt)/Abeta(42) and flies with LiCl ameliorates the exacerbating effect of Abeta(42), suggesting that GSK-3beta may be involved in the mechanism by which Abeta(42) and tau(wt) interact to cause neuronal dysfunction...
  12. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
    ..It was reported previously that overexpression of a second kinase, Shaggy (SGG)/Glycogen Synthase Kinase 3, accelerates PER nuclear accumulation...
  13. pmc Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila
    T B Chou
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Genetics 131:643-53. 1992
    ..We describe the parameters of FLP-recombinase induced germline mitotic recombination and the use of the "FLP-DFS" technique to analyze the maternal effect of X-linked zygotic lethal mutations...
  14. ncbi Components of wingless signalling in Drosophila
    E Siegfried
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Nature 367:76-80. 1994
    ..Wg signalling functions by inactivating or antagonizing the activity of zestewhite 3 (zw3)...
  15. ncbi Negative regulation of Armadillo, a Wingless effector in Drosophila
    L M Pai
    Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Development 124:2255-66. 1997
    ..We discuss two models for the negative regulation of Armadillo in normal development and discuss how escape from this regulation contributes to tumorigenesis...
  16. ncbi Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
    Y Ahmed
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Cell 93:1171-82. 1998
    ..Uncoupling of these two Arm-induced processes suggests a novel role for the Arm/dTCF complex in the activation of apoptosis...
  17. ncbi Frizzled signaling and the developmental control of cell polarity
    J M Shulman
    Wellcome CRC Institute, UK
    Trends Genet 14:452-8. 1998
    ..Recently described examples from the nematode and frog suggest that the developmental control of cell polarity by FZ receptors might represent a functionally conserved signaling mechanism...
  18. ncbi A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
    K Willert
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 126:4165-73. 1999
    ..The loss-of-function and overexpression phenotypes show that Daxin, like its mammalian counterpart, acts as a negative regulator of wg/Wnt signaling...
  19. pmc Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
    ..We discuss the implications of our results for Wg signaling, and suggest a role for dAPC2 as a mediator of Wg effects on the cytoskeleton. We also speculate on more general roles that APCs may play in cytoskeletal dynamics...
  20. ncbi APC: the plot thickens
    M Bienz
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Opin Genet Dev 9:595-603. 1999
    ..It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin...
  21. ncbi A new Drosophila APC homologue associated with adhesive zones of epithelial cells
    X Yu
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Cell Biol 1:144-51. 1999
    ..In a complex with glycogen synthase kinase-3 (GSK-3), APC binds to and destabilizes cytoplasmic ('free') beta-catenin...
  22. ncbi Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
    Thomas Kramps
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Cell 109:47-60. 2002
    ....
  23. ncbi Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development
    Yi A Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
    Development 131:2911-20. 2004
    ..These observations suggest that the patterning mechanism governed by Wg involves a negative feedback circuit in which Wg induces expression of its own antagonist Nemo...
  24. pmc A directed screen for genes involved in Drosophila blood cell activation
    Carl Johan Zettervall
    Umea Centre for Molecular Pathogenesis, Byggnad 6L, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 101:14192-7. 2004
    ..We conclude that the activation of a cellular response is complex and affected by multiple signaling pathways...
  25. pmc Intracellular shuttling of a Drosophila APC tumour suppressor homolog
    Adam Cliffe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    BMC Cell Biol 5:37. 2004
    ..Here, we ask whether the junctional association of E-APC is stable, or whether E-APC shuttles between the plasma membrane and the cytoplasm...
  26. ncbi TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
    Vikram Khurana
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, Massachusetts 02115, USA
    Curr Biol 16:230-41. 2006
    ..However, the critical questions of whether cell-cycle activation is causal or epiphenomenal to tau-induced neurodegeneration and which signaling pathways mediate cell-cycle activation in tauopathy remain unresolved...
  27. pmc A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity
    Pipat Nawathean
    Howard Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Mol Cell Biol 27:5002-13. 2007
    ..This is then followed by additional PER phosphorylation, which occurs within the nucleus and leads to PER degradation...
  28. pmc Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1)
    Yanshan Fang
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:1506-18. 2007
    ..However, PP1 does not act in a simple antagonistic manner to SHAGGY (SGG), the kinase that phosphorylates TIM, because the behavioral phenotypes produced by inhibiting PP1 in flies are ..
  29. ncbi Shaggy (zeste-white 3) and the formation of supernumerary bristle precursors in the developing wing blade of Drosophila
    S S Blair
    Department of Zoology, University of Wisconsin Madison 53706
    Dev Biol 152:263-78. 1992
    The development of supernumerary bristle precursors induced by the mutation shaggy (sgg; also known as zeste-white 3) was examined in the developing wing blade of imaginal and pupal Drosophila...
  30. ncbi Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase
    M Peifer
    Department of Biology, University of North Carolina at Chapel Hill 27599
    Dev Biol 166:543-56. 1994
    ..We discuss the implications of these results for regulation of Wingless/Wnt-1 signaling and adherens junction function...
  31. ncbi wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo
    M Peifer
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280
    Development 120:369-80. 1994
    ..We present a model for the role of Armadillo stripes in transduction of wingless signal...
  32. ncbi The wingless signalling pathway and the patterning of the wing margin in Drosophila
    J P Couso
    Department of Zoology, University of Cambridge, UK
    Development 120:621-36. 1994
    ..the wingless signal requires the activity of at least three genes: armadillo (arm), dishevelled (dsh) and shaggy (sgg) and that the functional relationship between these genes and wg is the same as that which exist during the ..
  33. pmc Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
    K Hughes
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 12:803-8. 1993
    Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase implicated in the cellular response to insulin...
  34. ncbi Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch
    L Ruel
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Faculte de Medecine, Strasbourg, France
    Nature 362:557-60. 1993
    ..the lateral signal and encodes serine/threonine protein kinases with homology to the glycogen synthase kinase-3 (GSK-3) enzymes that act in signal transduction pathways in vertebrates...
  35. pmc Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila
    L Ruel
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Faculte de Medecine, Strasbourg, France
    EMBO J 12:1657-69. 1993
    ..This protein probably also functions as part of a signal transduction cascade in the imaginal neuroepithelium, where cells have to choose between epidermal and neural fates...
  36. ncbi decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut
    X Yu
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 122:849-58. 1996
    ..As decapentaplegic itself is required for wingless expression in the midgut, this represents a positive feed-back loop between two cell groups signalling to each other to stimulate each other's signal production...
  37. ncbi wingless signaling in the Drosophila eye and embryonic epidermis
    K M Cadigan
    Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Development 122:2801-12. 1996
    ..However, we present evidence that wingless signaling still occurs normally in the complete absence of Notch protein in the embryonic epidermis. Thus, in the simplest model for wingless signalling, a direct role for Notch is unlikely...
  38. ncbi Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    V Stambolic
    Ontario Cancer Institute, Toronto, Canada
    Curr Biol 6:1664-8. 1996
    ..or disruption, respectively, of a highly conserved protein serine/threonine kinase, glycogen synthase kinase-3 (GSK-3)...
  39. ncbi Accumulation of Armadillo induced by Wingless, Dishevelled, and dominant-negative Zeste-White 3 leads to elevated DE-cadherin in Drosophila clone 8 wing disc cells
    S i Yanagawa
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto, 606 Japan
    J Biol Chem 272:25243-51. 1997
    ..In addition, overexpression of DE-cadherin elevated Arm levels by stabilizing Arm at cell-cell junctions...
  40. ncbi Linking Frizzled and Wnt signaling in Drosophila development
    A Tomlinson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 124:4515-21. 1997
    ..In addition, we show that overexpression of Shaggy (Sgg - another component of the Wnt pathway) in the eye also causes a phenotype similar to Fz and Dsh...
  41. ncbi Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis
    M Wehrli
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 125:1421-32. 1998
    ..Further, we show that the polarizing information acting in this equatorial/polar axis (Eq/Pl) is established in at least two steps - the activity of one signaling molecule functions to establish the graded activity of a second signal...
  42. ncbi Overexpression of zeste white 3 blocks wingless signaling in the Drosophila embryonic midgut
    M C Steitz
    Department of Biology and Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Dev Biol 197:218-33. 1998
    ..the signaling pathway of the Drosophila Wnt homologue, Wingless, have identified a number of genes, including zeste white 3, which function to transduce the Wingless signal. zeste white 3 encodes a serine/threonine kinase...
  43. ncbi Interactions between Wingless and DFz2 during Drosophila wing development
    J Zhang
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260 USA
    Development 125:3075-85. 1998
    ..These observations suggest that a single dominant-negative form of Fz or DFz2 can block more than one type of Wnt signaling pathway and imply that truncated proteins of the Fz family lose some aspect of signaling specificity...
  44. pmc Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 12:2610-22. 1998
    ..The PCP signal may selectively result in focal Fz activation and asymmetric relocalization of Dsh to the membrane, where Dsh effects cytoskeletal reorganization to orient prehair initiation...
  45. ncbi Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
    F Hamada
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita 565 0871, Japan
    Science 283:1739-42. 1999
    ..Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila...
  46. ncbi Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function
    W Helms
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Dev Biol 215:358-74. 1999
    ..This system should prove useful for the investigation of the role of Mam within the Notch pathway...
  47. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  48. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
    ..manner, a transduction step between the Wnt signaling components Dishevelled (Dsh) and Zeste-white 3 kinase (Zw3)...
  49. ncbi A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock
    S Martinek
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, NY 10021, USA
    Cell 105:769-79. 2001
    Tissue-specific overexpression of the glycogen synthase kinase-3 (GSK-3) ortholog shaggy (sgg) shortens the period of the Drosophila circadian locomotor activity cycle...
  50. ncbi Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan
    N S Tolwinski
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Development 128:2107-17. 2001
    ..We find that nuclear retention is dependent on dTCF/Pangolin. This suggests that cellular distribution of Arm is controlled by an anchoring system, where various nuclear and cytoplasmic binding partners determine its localization...
  51. ncbi Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Nat Cell Biol 3:933-8. 2001
    ..Together, these data suggest that APC2, Armadillo and alpha-catenin provide an important link between spindles and cortical actin, and that this link is regulated by Zeste-white 3 kinase...
  52. ncbi Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    Jianhang Jia
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Nature 416:548-52. 2002
    The Drosophila protein Shaggy (Sgg, also known as Zeste-white3, Zw3) and its vertebrate orthologue glycogen synthase kinase 3 (GSK3) are inhibitory components of the Wingless (Wg) and Wnt pathways...
  53. ncbi Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development
    Yashi Ahmed
    HHMI Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 129:1751-62. 2002
    ....
  54. ncbi The subcellular destinations of APC proteins
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Mol Cell Biol 3:328-38. 2002
    ..These destinations have prompted the discovery of new functions for the APC proteins, and this multitasking of APC might explain why its loss often leads to cancer...
  55. ncbi Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila
    David S Parker
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor 48109, USA
    Development 129:2565-76. 2002
    ..Our data argue strongly that Pygopus is a new core component of the Wg signaling pathway that acts downstream or at the level of TCF...
  56. ncbi Targeted increase in shaggy activity levels blocks wingless signaling
    Marc Bourouis
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
    Genesis 34:99-102. 2002
  57. ncbi The F-box protein slimb controls the levels of clock proteins period and timeless
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 420:178-82. 2002
    ..Because levels of Per and Tim oscillate in slmb mutants maintained in light:dark conditions, light- and clock-controlled degradation of Per and Tim do not rely on the same mechanisms...
  58. ncbi Similarities between the Hedgehog and Wnt signaling pathways
    Daniel Kalderon
    Department of Biological Sciences, Columbia University, New York NY 10027, USA
    Trends Cell Biol 12:523-31. 2002
    ..Recently, the common use of glycogen synthase kinase 3 and casein kinase 1 has been added to a growing list of straightforward similarities between Hedgehog ..
  59. ncbi Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?
    Mariann Bienz
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 5:179-82. 2003
    ..Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/beta-catenin...
  60. ncbi A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling
    Adam Cliffe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom
    Curr Biol 13:960-6. 2003
    ..as a scaffold in this complex, to assemble beta-catenin substrate and kinases (casein kinase I [CKI] and glycogen synthase kinase 3 beta [GSK3])...
  61. ncbi GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
    A Mudher
    Department of Neuroscience and Old Age Psychiatry, Institute of Psychiatry, Kings College London, De Crespigny Park, London, UK
    Mol Psychiatry 9:522-30. 2004
    ..Co-expression of constitutively active glycogen-synthase kinase-3beta (GSK-3beta) enhances and two GSK-3beta inhibitors, lithium and AR-A014418, reverse both the axon transport and locomotor ..
  62. ncbi PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila
    Isao Nishimura
    Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 116:671-82. 2004
    ..This phosphorylation event is a prerequisite for the action of downstream kinases, including glycogen synthase kinase 3 (GSK-3) and cyclin-dependent kinase-5 (Cdk5), to phosphorylate several other sites and generate disease-..
  63. pmc A nuclear function for armadillo/beta-catenin
    Nicholas S Tolwinski
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 2:E95. 2004
    ..Further, this activity is dependent on the presence of the C-terminus-specific negative regulator Chibby. Our data clearly show that nuclear localization of beta-catenin is in fact necessary for Wnt pathway activation...
  64. ncbi Armadillo/beta-catenin-dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila
    Veronique Morel
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Development 131:3273-83. 2004
    ..g. Flamingo, PCP Wingless signalling is not involved in DC...
  65. ncbi Trimeric G protein-dependent frizzled signaling in Drosophila
    Vladimir L Katanaev
    Department of Genetics and Development, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 701 West 168 Street, New York, NY 10032, USA
    Cell 120:111-22. 2005
    ..Thus, Go is likely part of a trimeric G protein complex that directly transduces Fz signals from the membrane to downstream components...
  66. ncbi Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
    Wensheng Zhang
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Dev Cell 8:267-78. 2005
    ..In Drosophila, Hh counteracts phosphorylation by PKA, GSK3, and CKI to prevent Cubitus interruptus (Ci) processing through unknown mechanisms...
  67. pmc Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity
    Penny Hayward
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Development 132:1819-30. 2005
    ..The modulatory function of Notch described here, contributes to the establishment of a robust threshold for Wnt signalling which is likely to play important roles in both normal and pathological situations...
  68. ncbi DNA-binding domain mutations in SMAD genes yield dominant-negative proteins or a neomorphic protein that can activate WG target genes in Drosophila
    Norma T Takaesu
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Development 132:4883-94. 2005
    ..From a larger perspective, our study shows that the genetic characterization of missense mutations, particularly in modular proteins, requires experimental verification...
  69. ncbi Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Cell 9:819-30. 2005
    ..Ci processing requires sequential phosphorylation by PKA, GSK3, and a casein kinase I (CKI) family member(s)...
  70. ncbi Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb
    Margery G Smelkinson
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Curr Biol 16:110-6. 2006
    ..phosphorylation of full-length Ci (Ci-155) by protein kinase A (PKA), casein kinase 1 (CK1), and glycogen synthase kinase 3 (GSK3), as well as the activity of Slimb ...
  71. pmc Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein
    Eun Young Kim
    Department of Molecular Biology and Biochemistry, Rutgers University, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:6178-83. 2006
    ....
  72. ncbi Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila
    Katy Wing Kam Chau
    Department of Biochemistry and Molecular Biotechnology Programme, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Biochem Biophys Res Commun 346:150-9. 2006
    ..that human Tau protein was phosphorylated by endogenous protein kinases in flies, and overexpression of either GSK3beta or Cdk5 enhanced tau-induced toxicity...
  73. ncbi Age-independent synaptogenesis by phosphoinositide 3 kinase
    Alfonso Martín-Peña
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 26:10199-208. 2006
    ..Thus, we propose that PI3K stimulation can be applied to prevent or delay synapse loss in normal aging and in neurological disorders...
  74. ncbi Lobe and Serrate are required for cell survival during early eye development in Drosophila
    Amit Singh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 133:4771-81. 2006
    ..5-fold higher frequency. This suggests that L or Ser loss-of-function triggers both caspase-dependent and -independent cell death. Our studies thus identify a mechanism responsible for cell survival in the early eye...
  75. ncbi Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
    Laurent Ruel
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Universite de Nice Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 02, France
    Development 134:3677-89. 2007
    ..This study provides new insight into the mechanistic regulation of the protein complex that mediates Hh signalling and a unique antibody tool for directly monitoring Hh receptor activity in all activated cells...
  76. pmc E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8
    Erick J Morris
    Laboratory of Molecular Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, 13th Street, Building 149, Charlestown, Massachusetts 02129, USA
    Nature 455:552-6. 2008
    ..deregulation suppresses beta-catenin activity in an adenomatous polyposis coli (APC)/glycogen synthase kinase-3 (GSK3)-independent manner, reducing the expression of key beta-catenin targets including c-MYC...
  77. pmc Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model
    Shreyasi Chatterjee
    Department of Neurology, Neurogenetics and Movement Disorders Programs, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:164-77. 2009
    ..play a role in such phosphorylation events include the proline-directed kinases glycogen synthase kinase-3beta (GSK-3beta) and cyclin-dependent kinase 5 (Cdk5), as well as nonproline-directed kinases such as microtubule affinity-..
  78. pmc Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction
    Claudia Miech
    F M Kirby Neurobiology Center, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 28:10875-84. 2008
    ..arrow/LRP (low-density lipoprotein receptor-related protein), dishevelled, and the glycogen synthase kinase shaggy (GSK3) and regulates the formation of microtubule loops within synaptic boutons as well as the number of synaptic boutons...
  79. pmc Membrane bound axin is sufficient for Wingless signaling in Drosophila embryos
    Nicholas S Tolwinski
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genetics 181:1169-73. 2009
    ..I find that nuclear localization of APC2 appears to be required, but Axin can block signaling when tethered to the membrane. These results support the model where Axin regulates Armadillo localization and activity in the cytoplasm...
  80. pmc Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases
    Margherita Galletti
    Department of Biology, City College of the City University of New York, 138th at Convent Ave, New York, NY 10031, USA
    Mol Cell Biol 29:3424-34. 2009
    ..is regulated in vitro and in vivo by members of the casein kinase 1 (CK1) family and by glycogen synthase kinase 3beta (GSK3beta)...
  81. doi GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels
    Pamela F Colosimo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Dyn 239:115-25. 2010
    ..We show that loss of the Wnt signaling component GSK3 beta results in increased levels of aPKC and leads to defects in apical-basal polarity...
  82. pmc Epithelial polarity: interactions between junctions and apical-basal machinery
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genetics 183:897-904. 2009
    ..Further, in embryos lacking the Wingless signaling component zw3, the same full apical expansion occurs again with only a reduction in lgl...
  83. doi Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 423, New York, NY 10021, USA
    J Cell Sci 123:3157-65. 2010
    ..We conclude that apical-basal proteins, used to establish polarity within a cell, can be independently co-opted to function in epithelial morphogenesis...
  84. pmc Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease
    Oyinkan Sofola
    Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing and Research, University College London, London, United Kingdom
    PLoS Genet 6:e1001087. 2010
    ..Glycogen synthase kinase-3 (GSK-3) is increasingly implicated as playing a pivotal role in this amyloid cascade...
  85. doi LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß
    Chin Hsien Lin
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    J Neurosci 30:13138-49. 2010
    ..Mechanistically, hyperactivated G2019S promotes tau phosphorylation at the T212 site by the Drosophila glycogen synthase kinase 3β homolog Shaggy (Sgg)...
  86. doi Synapse loss in olfactory local interneurons modifies perception
    Angel Acebes
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 31:2734-45. 2011
    ..Here we modified a PI3K/AKT/GSK3 signaling pathway to reduce the number of synapses--without affecting the number of cells--in five subsets of local ..
  87. pmc The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
    Qing Shi
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Development 138:4219-31. 2011
    ....
  88. doi Central adaptation to odorants depends on PI3K levels in local interneurons of the antennal lobe
    Angel Acebes
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 32:417-22. 2012
    ....
  89. ncbi Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy
    R P de Groot
    Laboratoire de Génétique Moléculaire des Eucaryotes de CNRS, Unité 184 de l INSERM, Faculte de Medecine, Strasbourg, France
    Oncogene 8:841-7. 1993
    ..It has been shown that phosphorylation mediated by glycogen synthase kinase 3 (GSK-3) is involved in negative regulation of c-Jun DNA-binding function in vitro...
  90. pmc Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster
    Deppie Papadopoulou
    ISBDC, CNRS UMR 6543 Centre de Biochimie, Universite de Nice, 06108 Nice Cedex 2, France
    Mol Cell Biol 24:4909-19. 2004
    Early studies of glycogen synthase kinase 3 (GSK-3) in mammalian systems focused on its pivotal role in glycogen metabolism and insulin-mediated signaling...
  91. ncbi The genetic basis of patterned baldness in Drosophila
    N Perrimon
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 76:781-4. 1994
  92. pmc The making of a maggot: patterning the Drosophila embryonic epidermis
    S DiNardo
    Rockefeller University, New York, New York
    Curr Opin Genet Dev 4:529-34. 1994
    ..These signals mediate a mutually re-enforcing interaction between the two rows of cells to sustain organizer function. In a distinct and subsequent phase, wingless and hedgehog act to specify the fates of cells...
  93. ncbi Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos
    L Ruel
    Division of Experimental Therapeutics, Ontario Cancer Institute, and the Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 274:21790-6. 1999
    The protein-serine kinase Shaggy(Zeste-white3) (Sgg(Zw3)) is the Drosophila homolog of mammalian glycogen synthase kinase-3 and has been genetically implicated in signal transduction pathways necessary for the establishment of patterning...
  94. pmc Complementation analysis of methyl methane-sulfonate-induced recessive lethal mutations in the zeste-white region of the X chromosome of Drosophila melanogaster
    C P Liu
    Genetics 79:601-11. 1975
    ....
  95. ncbi Patterning of the Drosophila nervous system: the achaete-scute gene complex
    S Campuzano
    Centro de Biologia Molecular, CSIC, Madrid, Spain
    Trends Genet 8:202-8. 1992
    ..Neuroblasts or sensory organ mother cells are born within these clusters. Thus, the patterns of expression of the AS-C genes help to define the topology of the nervous system...
  96. ncbi Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila
    P Simpson
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg
    Development 109:509-19. 1990
    ..The molecular nature of the protein products of the neurogenic genes is consistent with this idea...
  97. ncbi Mutant Drosophila embryos in which all cells adopt a neural fate
    M Bourouis
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Nature 341:442-4. 1989
    ..The neurogenic class of genes is thought to mediate these cell interactions. Here we report that cells in embryos mutant for shaggy which are unable to adopt any of the early initial fates, instead develop neural characteristics...
  98. pmc The anatomy and function of a segment of the X chromosome of Drosophila melanogaster
    B H Judd
    Genetics 71:139-56. 1972
    ..The data clearly show one functional group per chromomere. It is postulated that a chromomere is one cistron within which much of the DNA is regulatory in function...
  99. pmc Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster
    M P Shannon
    Genetics 72:615-38. 1972
    ..These results provide additional evidence that only one function is associated with each chromomere.-The results of the lethality pattern analysis are also compared with previous studies of lethal mutants of Drosophila...
  100. ncbi The body language of cells: the intimate connection between cell adhesion and behavior
    M W Klymkowsky
    University of Colorado, Boulder, Colorado 80309 0347, USA
    Cell 83:5-8. 1995
  101. ncbi Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless
    M Gonzalez-Gaitan
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Development 121:2313-25. 1995
    ..Our results suggest that the wingless pathway acts not as an instructive signal, but as a permissive factor which coordinates the spatial activity of morphoregulatory signals within the stomatogastric nervous system anlage...

Research Grants16

  1. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..
  2. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
    ..Further, these in vivo studies may help in understanding the basis of some dysmorphologies in humans. ..
  3. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2005
    ..Finally, we have identified a collection of mutants affecting disc growth patterns that serve as an enriched collection of new candidate genes to participate in these events. ..
  4. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  5. Conference on Wnt and Beta Catenin Signaling
    Randall Moon; Fiscal Year: 2002
    ..Given the explosive growth in research in this field owing to its connection to various cancers, it is extremely timely to have a meeting with the joint focus on the roles of Wnt and B-catenin signaling in both development and disease. ..
  6. Mechanisms governing polarity in Drosophila oogenesis
    Daniel Kalderon; Fiscal Year: 2004
    ....
  7. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005
    ..Mutations identified from this screen will provide entry points to dissect genetic and molecular pathways involved in vertebrate organogenesis. ..
  8. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. Lipid droplets as sites for protein sequestration
    MICHAEL WELTE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
    ..The health relatedness of these studies is that an understanding of circuits underlying sensory perception is relevant for brain disorders with a neurological or psychiatric basis. ..
  11. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..g., Wnt-1) acting to stabilize beta-catenin. The glycogen synthase kinase 3beta (GSK3beta) protein functions in concert with the Axin and APC (adenomatous polyposis coli) tumor ..
  12. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  13. SCF complex and the Drosophila centrosome cycle
    EDWARD JOHN WOJCIK; Fiscal Year: 2010
    ..These discoveries will provide new diagnostic or therapeutic targets for the prevention or treatment of cancer. ..
  14. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011
    ..The Health-Relatedness of this proposal is that such chemical agents may act to reduce infectious disease transmission by vector insects in the future. ..
  15. Molecular Genetics of Polyglutamine-Induced Degeneration
    George Jackson; Fiscal Year: 2003
    ..abstract not available ..
  16. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
    ..The health relatedness of these studies is that cellular and molecular factors that regulate axonal pathfinding may have direct application to neurological and psychiatric disorders with a developmental basis. ..