shakB

Summary

Gene Symbol: shakB
Description: shaking B
Alias: CG12678, CG1321, CG15451, CG32508, CG34358, Dmel\CG34358, Dmel_CG12678, Dmel_CG32508, E81, FBpp0111481, Pas, R-9-29, R9-29, Shak B, Shak-B, ShakB, inx8, l(1)19Eb, l(1)LB21, l(1)R-10-14, l(1)R-10-3, l(1)R-10-7, l(1)R-9-29, l(1)TH73, l(1)W3, l(1)W3b, lincRNA.1031, nj-156, nj156, pas, pass, shB, shak-B, shkB, CG34358 gene product from transcript CG34358-RH, CG34358-PA, CG34358-PC, CG34358-PD, CG34358-PE, CG34358-PF, CG34358-PG, CG34358-PH, CG34358-PI, Shaking-B, non-jumper-156, passover, passover-vital protein, section 2, section 3, section 6, shakB-PA, shakB-PC, shakB-PD, shakB-PE, shakB-PF, shakB-PG, shakB-PH, shakB-PI
Species: fruit fly

Top Publications

  1. ncbi The shaking B gene in Drosophila regulates the number of gap junctions between photoreceptor terminals in the lamina
    M Shimohigashi
    Neuroscience Institute, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurobiol 35:105-17. 1998
  2. ncbi Genes, gene knockouts, and mutations in the analysis of gap junctions
    C W Lo
    Department of Biology, University of Pennsylvania, Philadelphia 19104 6017, USA
    Dev Genet 24:1-4. 1999
  3. ncbi Passover: a gene required for synaptic connectivity in the giant fiber system of Drosophila
    S N Krishnan
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Cell 73:967-77. 1993
  4. ncbi Essential and neural transcripts from the Drosophila shaking-B locus are differentially expressed in the embryonic mesoderm and pupal nervous system
    D Crompton
    School of Biological Sciences, Sussex University, Falmer, Brighton, United Kingdom
    Dev Biol 170:142-58. 1995
  5. ncbi Passover eliminates gap junctional communication between neurons of the giant fiber system in Drosophila. off
    Y A Sun
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    J Neurobiol 30:340-8. 1996
  6. ncbi Innexins get into the gap
    P Phelan
    Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
    Bioessays 23:388-96. 2001
  7. ncbi Drosophila Shaking-B protein forms gap junctions in paired Xenopus oocytes
    P Phelan
    Sussex Centre for Neuroscience, Brighton, UK
    Nature 391:181-4. 1998
  8. ncbi Synaptogenesis in the giant-fibre system of Drosophila: interaction of the giant fibre and its major motorneuronal target
    K Jacobs
    Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK
    Development 127:5203-12. 2000
  9. ncbi Nested transcripts of gap junction gene have distinct expression patterns
    Z Zhang
    Department of Molecular, Cellular and Developmental Biology, 610 KBT, Yale University, P O Box 208103, New Haven, Connecticut 06520, USA
    J Neurobiol 40:288-301. 1999
  10. ncbi Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila
    M J Allen
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 19:9374-84. 1999

Research Grants

  1. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
  2. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010

Scientific Experts

  • K D Curtin
  • John E Pool
  • Vincent T Cunliffe
  • Austin Hughes
  • Marcus J Allen
  • Juan Song
  • Pauline Phelan
  • L A Stebbings
  • G O Pflugfelder
  • Salli I Tazuke
  • J M Blagburn
  • Maria Luisa Chiusano
  • M D Egger
  • C W Lo
  • Adeline P Pézier
  • Christopher M Smendziuk
  • William D Marks
  • I Martha Skerrett
  • Christopher J H Elliott
  • Indulekha P Sudhakaran
  • Adam Depriest
  • Chia Lin Wu
  • Emre Yaksi
  • Maaria Kankare
  • Sarah Hammond
  • R J Wyman
  • M G Todman
  • Jonathan P Bacon
  • Sami H Jezzini
  • Anat Messenberg
  • Guy Tanentzapf
  • A Wayne Vogl
  • Andreas Keller
  • J F Brookfield
  • Sahar Osman
  • Eimear E Holohan
  • John C Sparrow
  • Veronica Rodrigues
  • Mani Ramaswami
  • K Vijayraghavan
  • D Nurminsky
  • D Kuebler
  • Meng Fu Maxwell Shih
  • Ann Shyn Chiang
  • Hsun Ti Yang
  • J A Davies
  • Y A Sun
  • Jason Sih Yu Lai
  • Glenn C Turner
  • Linyi Chen
  • Tiina Salminen
  • Asta Laiho
  • K Jacobs
  • Anneli Hoikkala
  • Laura Vesala
  • Rachel I Wilson
  • J P Bacon
  • D A Burden
  • Z Zhang
  • Michael O'Shea
  • M Shimohigashi
  • S N Krishnan
  • E Johnson
  • J R Trimarchi
  • Troy Zars
  • Martin Heisenberg
  • Sean T Sweeney
  • Cahir J O'Kane
  • D L Hartl
  • M A Tanouye
  • D D Aguiar
  • X Ren
  • H Zhang
  • C D Bustamante
  • R K Murphey
  • D Crompton
  • R A Baines
  • N Osheroff
  • G L Miklos
  • E Frei
  • M A Seeger
  • I A Meinertzhagen
  • D H Baird
  • J Ringo
  • H Dowse
  • E Lifschytz
  • R W Phillis
  • A P Schalet
  • G S Boyan
  • S Ji

Detail Information

Publications69

  1. ncbi The shaking B gene in Drosophila regulates the number of gap junctions between photoreceptor terminals in the lamina
    M Shimohigashi
    Neuroscience Institute, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurobiol 35:105-17. 1998
    ..structure of insect gap junctions differs from that in vertebrates, and in Drosophila is possibly encoded by the shaking B (= Passover) locus. shaking B2 is a null allele that acts in the nervous system...
  2. ncbi Genes, gene knockouts, and mutations in the analysis of gap junctions
    C W Lo
    Department of Biology, University of Pennsylvania, Philadelphia 19104 6017, USA
    Dev Genet 24:1-4. 1999
    ..It may be timely to form a Nomenclature Committee to establish a uniform classification scheme for naming gap junction proteins...
  3. ncbi Passover: a gene required for synaptic connectivity in the giant fiber system of Drosophila
    S N Krishnan
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Cell 73:967-77. 1993
    b>Passover (Pas) flies fail to jump in response to a light-off stimulus. The mutation disrupts specific synapses of the giant fibers (GFs), command neurons for this response. Pas was cloned from a P element-induced allele...
  4. ncbi Essential and neural transcripts from the Drosophila shaking-B locus are differentially expressed in the embryonic mesoderm and pupal nervous system
    D Crompton
    School of Biological Sciences, Sussex University, Falmer, Brighton, United Kingdom
    Dev Biol 170:142-58. 1995
    ....
  5. ncbi Passover eliminates gap junctional communication between neurons of the giant fiber system in Drosophila. off
    Y A Sun
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    J Neurobiol 30:340-8. 1996
    The Passover-related gene family plays significant roles in cellular connectivity. Mutations in three family members from Drosophila and from Caenorhabditis elegans alter a few specific electrical synapses...
  6. ncbi Innexins get into the gap
    P Phelan
    Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
    Bioessays 23:388-96. 2001
    ..The completed genomic sequences for the fly and worm allow identification of the full complement of innexin genes in these two organisms and provide valuable resources for genetic analyses of gap junction function...
  7. ncbi Drosophila Shaking-B protein forms gap junctions in paired Xenopus oocytes
    P Phelan
    Sussex Centre for Neuroscience, Brighton, UK
    Nature 391:181-4. 1998
    ..To our knowledge, this is the first structural component of an invertebrate gap junction to be characterized...
  8. ncbi Synaptogenesis in the giant-fibre system of Drosophila: interaction of the giant fibre and its major motorneuronal target
    K Jacobs
    Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK
    Development 127:5203-12. 2000
    ..This results in the Giant Fibre remaining stranded at the midline, unable to make its characteristic bend. We conclude that Giant Fibre morphogenesis normally relies on fasciculation with its major motorneuronal target...
  9. ncbi Nested transcripts of gap junction gene have distinct expression patterns
    Z Zhang
    Department of Molecular, Cellular and Developmental Biology, 610 KBT, Yale University, P O Box 208103, New Haven, Connecticut 06520, USA
    J Neurobiol 40:288-301. 1999
    The shaking B locus (shakB, or Passover) codes for structural molecules of gap junctions in Drosophila. This report describes the complex set of transcripts from the shakB locus. A nested set of five transcripts is described...
  10. ncbi Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila
    M J Allen
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 19:9374-84. 1999
    ..We speculate that disrupting transport of a retrograde signal disrupts synapse formation and maturation...
  11. ncbi Mutations in shaking-B prevent electrical synapse formation in the Drosophila giant fiber system
    P Phelan
    Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton, United Kingdom
    J Neurosci 16:1101-13. 1996
    ..The mutation shak-B2, which eliminates protein expression, prevents the establishment of dye coupling shaking-B, therefore, is essential for the assembly and/or maintenance of functional gap junctions at electrical synapses in the GFS...
  12. ncbi Mutations altering synaptic connectivity between identified neurons in Drosophila
    J B Thomas
    J Neurosci 4:530-8. 1984
    ..One mutation, bendless, disrupts synaptic transmission between the GF and the TTM motor neuron. Another, gfA, disrupts the synaptic connections of the PSI, and a third mutation, passover, disrupts transmission in both pathways.
  13. ncbi The shaking-B2 mutation disrupts electrical synapses in a flight circuit in adult Drosophila
    J R Trimarchi
    Department of Biology, Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 17:4700-10. 1997
    ..Together, these results show that the haltere-to-flight motoneuron synapses comprise an electrical component that requires shaking-B and a chemical component that is likely to be cholinergic...
  14. ncbi Null mutation in shaking-B eliminates electrical, but not chemical, synapses in the Drosophila giant fiber system: a structural study
    J M Blagburn
    Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan 00901, USA
    J Comp Neurol 404:449-58. 1999
    ..Gap junctions with more vertebratelike separation of membranes (1.41 nm +/- 0.08) were abundant between peripheral perineurial glial processes; these were unaffected in the mutants...
  15. pmc The Passover locus in Drosophila melanogaster: complex complementation and different effects on the giant fiber neural pathway
    D H Baird
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Genetics 126:1045-59. 1990
    Drosophila melanogaster bearing the Passover mutation fail to jump in response to a light-off stimulus. Pas also disrupts some of the synapses between the neurons of the giant fiber system which mediate this escape behavior...
  16. ncbi Gap junction proteins expressed during development are required for adult neural function in the Drosophila optic lamina
    Kathryn D Curtin
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA
    J Neurosci 22:7088-96. 2002
    ..Here we show that developmental gap junction genes can be required for normally functioning neural connections to form...
  17. pmc Shaking B Mediates Synaptic Coupling between Auditory Sensory Neurons and the Giant Fiber of Drosophila melanogaster
    Adeline P Pézier
    Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, United States of America
    PLoS ONE 11:e0152211. 2016
    ..The GF is known to express Shaking B (ShakB), specifically the ShakB(N+16) isoform only, at its output synapses in the thorax...
  18. doi Role of amino terminus in voltage gating and junctional rectification of Shaking B innexins
    William D Marks
    Biology Department, State University of New York, Buffalo State, Buffalo, New York and
    J Neurophysiol 111:1383-95. 2014
    ..giant fiber system, adjacent cells express and contribute different transcript variants of the innexin Shaking B, resulting in heterotypic gap junctions with rectifying properties...
  19. doi Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms
    Vincent T Cunliffe
    Bateson Centre, Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom Electronic address
    Seizure 24:44-51. 2015
    ..The short generation times of most of these model organisms also mean that they lend themselves particularly conveniently to the investigation of drug effects or epileptogenic processes across the lifecourse. ..
  20. doi Bi-directional gap junction-mediated soma-germline communication is essential for spermatogenesis
    Christopher M Smendziuk
    Department of Cellular and Physiological Sciences, 2350 Health Sciences Mall, University of British Columbia, Vancouver, Canada V6T 1Z3
    Development 142:2598-609. 2015
    ..Moreover, we show that stem cell maintenance and differentiation in the testis are directed by gap junction-derived cues. ..
  21. pmc The Mosaic Ancestry of the Drosophila Genetic Reference Panel and the D. melanogaster Reference Genome Reveals a Network of Epistatic Fitness Interactions
    John E Pool
    Laboratory of Genetics, University of Wisconsin Madison
    Mol Biol Evol 32:3236-51. 2015
    ..These findings suggest that admixed D. melanogaster samples could become an important study system for the genetics of early-stage isolation between populations. ..
  22. doi Plasticity of recurrent inhibition in the Drosophila antennal lobe
    Indulekha P Sudhakaran
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 32:7225-31. 2012
    ..Thus, PN output is monitored by an LN subtype whose resultant plasticity underlies behavioral habituation. We propose that recurrent inhibitory motifs common in neural circuits may similarly underlie habituation to other complex stimuli...
  23. pmc Tryptophan scanning mutagenesis of the first transmembrane domain of the innexin Shaking-B(Lethal)
    Adam Depriest
    Biology Department, Buffalo State College, Buffalo, New York, USA
    Biophys J 101:2408-16. 2011
    ..In addition, several mutations induced hemichannel activity. These changes are similar to those observed after substitutions within the transmembrane domains of connexins...
  24. doi In vivo measurement of muscle output in intact Drosophila
    Christopher J H Elliott
    Department of Biology, University of York, York YO10 5DD, UK
    Methods 56:78-86. 2012
    ..We have now extended the use of the apparatus to record the muscle forces during larval and other aspects of adult locomotion. The robustness, simplicity and versatility of the apparatus are key to these measurements...
  25. doi Heterotypic gap junctions between two neurons in the drosophila brain are critical for memory
    Chia Lin Wu
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan
    Curr Biol 21:848-54. 2011
    ..in the regulation of neuronal metabolism and homeostasis by serving as connections that enable small molecules to pass between cells and synchronize activity between cells...
  26. pmc Electrical coupling between olfactory glomeruli
    Emre Yaksi
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 67:1034-47. 2010
    ..We propose that when stimuli are weak, lateral excitation promotes sensitivity, whereas when stimuli are strong, lateral excitation helps recruit inhibitory gain control...
  27. pmc Changes in gene expression linked with adult reproductive diapause in a northern malt fly species: a candidate gene microarray study
    Maaria Kankare
    Centre of Excellence in Evolutionary Research, Department of Biological and Environmental Science, P O Box 35, 40014 University of Jyväskylä, Finland
    BMC Ecol 10:3. 2010
    ..This array gave us a chance to filter out genes showing expression changes during photoperiodic reproductive diapause in a species adapted to live in northern latitudes with high seasonal changes in environmental conditions...
  28. pmc The chemical component of the mixed GF-TTMn synapse in Drosophila melanogaster uses acetylcholine as its neurotransmitter
    Marcus J Allen
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Eur J Neurosci 26:439-45. 2007
    ..Our findings show that the two components of this synapse can be separated to allow further studies into the mechanisms by which mixed synapses are built and function...
  29. pmc Molecular mechanism of rectification at identified electrical synapses in the Drosophila giant fiber system
    Pauline Phelan
    Department of Biosciences, University of Kent, Canterbury, UK
    Curr Biol 18:1955-60. 2008
    ..These data provide the most definitive evidence to date that rectification is achieved by differential regulation of the pre- and postsynaptic elements of structurally asymmetric junctions...
  30. ncbi Population genetics: the signature of selection
    J F Brookfield
    Institute of Genetics, University of Nottingham, Queens Medical Centre, NG7 2UH, Nottingham, UK
    Curr Biol 11:R388-90. 2001
    ..New work on Drosophila genes that seem to have been subject to adaptive changes illustrates the difficulties in calculating the statistical significance of data trends that seem to show this...
  31. ncbi Genetic suppression of seizure susceptibility in Drosophila
    D Kuebler
    Department of Molecular and Cell Biology, Division of Neurobiology, University of California, Berkeley, CA 94720, USA
    J Neurophysiol 86:1211-25. 2001
    ..These results demonstrate the utility of Drosophila as a model system for studying seizure susceptibility and identify physiological processes that modify seizure susceptibility...
  32. ncbi Targeted expression of tetanus neurotoxin interferes with behavioral responses to sensory input in Drosophila
    Andreas Keller
    Institut für Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    J Neurobiol 50:221-33. 2002
    ..To increase the utility of the GAL4 system for such purposes, we have designed an inducible system that allows us to circumvent lethality caused by TNT expression during early development...
  33. ncbi Gap junctions in Drosophila: developmental expression of the entire innexin gene family
    Lucy A Stebbings
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Mech Dev 113:197-205. 2002
    ..This work forms an essential basis for future studies of innexin interactions in Drosophila and outlines the potential extent of gap-junction involvement in development...
  34. ncbi A germline-specific gap junction protein required for survival of differentiating early germ cells
    Salli I Tazuke
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Development 129:2529-39. 2002
    ....
  35. ncbi Gap junction proteins are not interchangeable in development of neural function in the Drosophila visual system
    Kathryn D Curtin
    Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
    J Cell Sci 115:3379-88. 2002
    ..Mutations in either of two Drosophila GJ genes (innexins), shakB and ogre, lead to a loss of transients in the electroretinogram (ERG), which is indicative of a failure of the ..
  36. ncbi The mutations previously designated as flightless-I3, flightless-O2 and standby are members of the W-2 lethal complementation group at the base of the X-chromosome of Drosophila melanogaster
    G L Miklos
    Molecular Neurobiology Group, Research School of Biological Sciences, Australian National University, Canberra ACT
    J Neurogenet 6:133-51. 1990
    ..These viable flightless mutations are all hypomorphs since the homozygous deficiency of the W-2 X-chromosomal region is lethal to the organism...
  37. ncbi A possible flip-flop genetic mechanism for reciprocal gene expression
    Maria Luisa Chiusano
    Department of Genetics, General and Molecular Biology, University of Naples Federico II, Via Mezzocannone, 8, 80134 Naples, Italy
    FEBS Lett 579:4919-22. 2005
    ..melanogaster cellular compartments. We propose here a new and robust mechanism, based on our analysis of the genomic organization of inx-2 and inx-7, that structurally justifies the reciprocal expression of genes...
  38. ncbi Seizure suppression by shakB2, a gap junction mutation in Drosophila
    Juan Song
    Department of Environmental Science, Policy and Management, Division of Insect Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Neurophysiol 95:627-35. 2006
    Gap junction proteins mediate electrical synaptic transmission. In Drosophila, flies carrying null mutations in the shakB locus, such as shakB2, have behavioral and electrophysiological defects in the giant fiber (GF) system neurocircuit ..
  39. ncbi Chromosome structure at interfaces between major chromatin types: alpha- and beta-heterochromatin
    G L Miklos
    Molecular Neurobiology Group, Research School of Biological Sciences, Australian National University, Canberra
    Bioessays 12:1-6. 1990
    ..The recent microcloning of part of this region, the isolation of a monoclonal antibody to a beta-heterochromatin binding protein, and new in situ studies now shed a little more light on this chromosomal region...
  40. ncbi Ontogeny of flight initiation in the fly Drosophila melanogaster: implications for the giant fibre system
    Sarah Hammond
    Sussex Centre for Neuroscience, University of Sussex, Brighton, BN1 9QG, UK
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:1125-37. 2007
    ..Thus, the escape mechanism is subject to developmental modulation following eclosion and the GF system does not underlie voluntary flight...
  41. ncbi A deficiency chromosome in Drosophila alters neuritic projections in an identified motoneuron
    G P Swain
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854 5635
    Brain Res 535:147-50. 1990
    ....
  42. ncbi The shaker and shaking-B genes specify elements in the processing of gustatory information in Drosophila melanogaster
    R Balakrishnan
    Molecular Biology Unit, Tata Institute of Fundamental Research, Bombay, India
    J Exp Biol 157:161-81. 1991
    ..Mutants at this locus show increased thresholds for detection of sucrose and fructose and lack the attraction response to 0.1 mol l-1 sodium chloride that is exhibited by the wild-type fly...
  43. ncbi Molecular analysis of the lethal(1)B214 region at the base of the X chromosome of Drosophila melanogaster
    R J Russell
    CSIRO Division of Entomology, Canberra, A C T, Australia
    Chromosoma 101:456-66. 1992
    ....
  44. ncbi The segmentation gene runt is needed to activate Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila
    M Torres
    Centro de Investigaciones Biologicas, Madrid, Spain
    Genet Res 59:189-98. 1992
    ..We conclude that runt is needed for the initial step of Sex-lethal activation, but does not have a major role as an X-counting element...
  45. ncbi Analysis of a cDNA from the neurologically active locus shaking-B (Passover) of Drosophila melanogaster
    D E Crompton
    Institute of Genetics, University of Glasgow, UK
    Gene 122:385-6. 1992
    ..melanogaster gene, l(1)ogre. This suggests the existence of a new family of proteins required for the development and maintenance of the D. melanogaster nervous system...
  46. ncbi The role of X-linked lethal and viable male-sterile mutations in male gametogenesis of Drosophila melanogaster: genetic analysis
    E Lifschytz
    Mol Gen Genet 161:275-84. 1978
    ..It is further shown that about the same proportion of vital genes is operating in female gonads and that the two groups overlap by about 70%. The role of viable and lethal male gametogenesis is discussed in detail...
  47. ncbi Genetic lesions in Drosophila behavioural mutants
    G O Pflugfelder
    Theodor Boveri Institut Biozentrum, Lehrstuhl fur Genetik, Universität Würzburg Am Hubland, Germany
    Behav Brain Res 95:3-15. 1998
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations...
  48. ncbi Genetic and molecular dissection of axon pathfinding in the Drosophila nervous system
    M A Seeger
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104 5073
    Curr Opin Neurobiol 4:56-62. 1994
    ....
  49. ncbi Dendritic reduction in Passover, a Drosophila mutant with a defective giant fiber neuronal pathway
    D H Baird
    Department of Anatomy and Neurobiology, Medical College of Pennsylvania, Philadelphia 19129
    J Neurobiol 24:971-84. 1993
    ..Flies bearing the X-chromosome mutation Passover (Pas) fail to jump in response to a light-off stimulus, and electrical stimulation of the GF in the brain no ..
  50. pmc Isolation of mutations affecting neural circuitry required for grooming behavior in Drosophila melanogaster
    R W Phillis
    Department of Biology, University of Massachusetts, Amherst 01003
    Genetics 133:581-92. 1993
    ..We have also used our assay to test the grooming ability of stocks containing mutations that produce known neural defects...
  51. pmc Molecular basis of intracistronic complementation in the Passover locus of Drosophila
    S N Krishnan
    Department of Biology, Yale University, New Haven, CT 06511
    Proc Natl Acad Sci U S A 92:2021-5. 1995
    ..The Drosophila neural mutant Passover (Pas) disrupts specific synaptic connections...
  52. ncbi Behavioral mutants of Drosophila melanogaster. III. Isolation and mapping of mutations by direct visual observations of behavioral phenotypes
    T Homyk
    Mol Gen Genet 177:553-65. 1980
    ....
  53. ncbi Effect of storage and dose on MMS-induced deletions. Complementation analysis of X-chromosomal recessive lethals in the zeste-white and maroon-like regions of Drosophila melanogaster
    E Paradi
    Mutat Res 111:145-59. 1983
    ..An interesting aspect for further analysis is the apparent infrequency in the zeste-white region of alkylation-induced chromosomal breakage, as observed by various investigators for MMS, EMS and MNNG...
  54. ncbi Modulation of Drosophila heartbeat by neurotransmitters
    E Johnson
    Department of Zoology, University of Maine, Orono 04469, USA
    J Comp Physiol B 167:89-97. 1997
    ..Dopamine-N-acetyltransferase, which is on the catabolic route to dopamine, serotonin, and octopamine, has no effect. hypoactiveC reduces the rate of the heart, but its mechanism of action is unknown...
  55. ncbi Fine structure analysis of a chromosome segment in Drosophila melanogaster: analysis of ethyl methanesulphonate-induced lethals
    E Lifschytz
    Mutat Res 8:147-55. 1969
  56. ncbi Patterns of connectivity in a Drosophila nerve
    M D Egger
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Comp Neurol 387:63-72. 1997
    ..The distribution of synaptic profiles was also examined in a mutant strain, Passover (Pas), known to affect connectivity in a pathway that includes the PAPSI...
  57. ncbi Fine structure analysis of a chromosome segment in Drosophila melanogaster. Analysis of x-ray-induced lethals
    E Lifschytz
    Mutat Res 6:235-44. 1968
  58. ncbi The grasshopper, Drosophila and neuronal homology (advantages of the insect nervous system for the neuroscientist)
    G S Boyan
    Zoologisches Institut, Universitat Basel, Switzerland
    Prog Neurobiol 41:657-82. 1993
  59. pmc Innexins: a family of invertebrate gap-junction proteins
    P Phelan
    Trends Genet 14:348-9. 1998
  60. ncbi The localization of "ordinary" sex-linked genes in section 20 of the polytene X chromosome of Drosophila melanogaster
    A Schalet
    Chromosoma 44:183-202. 1973
  61. ncbi In vitro evolution of preferred topoisomerase II DNA cleavage sites
    D A Burden
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 274:5227-35. 1999
    ..melanogaster, implying that it may be a site for the physiological action of this enzyme...
  62. ncbi Gap-Junctional communication between developing Drosophila muscles is essential for their normal development
    M G Todman
    Sussex Centre for Neuroscience, University of Sussex, Brighton, UK
    Dev Genet 24:57-68. 1999
    ..Our observations show that Shak-B(neural) is one of a set of embryonic gap-junction proteins, and that it is required for the normal temporal development of potassium currents in some larval muscles...
  63. ncbi Drosophila has several genes for gap junction proteins
    K D Curtin
    Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA
    Gene 232:191-201. 1999
    ..We have used PCR techniques to identify three new members of this family from Drosophila. These are designated pas-related proteins (prp) 6, 7, and 33...
  64. ncbi Localization of the genes shaking-B, small optic lobes, sluggish-A, stoned and stress-sensitive-C to a well-defined region on the X-chromosome of Drosophila melanogaster
    G L Miklos
    J Neurogenet 4:1-19. 1987
    ....
  65. ncbi Some mutations affecting neural or muscular tissues alter the physiological components of the electroretinogram in Drosophila
    T Homyk
    Department of Biological Sciences, Purdue University, W Lafayette, Indiana 47906
    J Neurogenet 5:37-48. 1989
    ..Mutations bas, rex and sesD delay recovery from the prolonged depolarization afterpotential. The visual defects of mutations elavjl and nbAEE171 are not complemented by lethal mutations, which, presumably, affect other tissues...
  66. pmc Two Drosophila innexins are expressed in overlapping domains and cooperate to form gap-junction channels
    L A Stebbings
    Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton, BN1 9QG, United Kingdom
    Mol Biol Cell 11:2459-70. 2000
    ..We conclude that Dm-Inx2 and Dm-Inx3, which are expressed in overlapping domains during embryogenesis, can form oligomeric gap-junction channels...
  67. pmc Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster
    N Perrimon
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genetics 121:313-31. 1989
    ..Additionally, all lethal complementation groups, as well as a specific subset of deficiencies, have been studied histologically for defects in the development of the central and peripheral embryonic nervous systems...
  68. ncbi Chromosomal effects of rapid gene evolution in Drosophila melanogaster
    D Nurminsky
    Department of Anatomy and Cell Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Science 291:128-30. 2001
    ..These findings imply that the pattern of genetic variation along a chromosome may be useful for inferring its evolutionary history and for revealing regions in which recent adaptive fixations have taken place...

Research Grants2

  1. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  2. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..