stg

Summary

Gene Symbol: stg
Description: string
Alias: 0224/06, 0245/03, 0439/22, 0730/13, 0896/05, 0967/05, 0980/06, 1083/13, 1089/08, 1143/02, 5473, CDC25, CDC25[string], CG1395, Cdc25, Cdc25[Stg], Cdc25[String], Cdc25[stg], Cdc25[string], Cdc25c, Dmel\CG1395, EP1213, S(rux)3A, STG, SY3-4, Stg, String/Cdc25, anon-EST:Liang-2.21, cdc25, cdc25[string], clone 2.21, l(3)01235, l(3)j10B9, l(3)j1D3, l(3)j1E3, l(3)j3D1, l(3)s2213, stg[cdc25], str/cdc25, CG1395 gene product from transcript CG1395-RA, CG1395-PA, CG1395-PB, Cdc25, String/Cdc25 phosphatase, cdc25/string, stg-PA, stg-PB, string/cdc25, suppressor of rux 3A
Species: fruit fly

Top Publications

  1. ncbi A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
    J C de Nooij
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Cell 87:1237-47. 1996
  2. ncbi Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25
    Achim Reber
    BZMB, Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
    Development 133:3201-11. 2006
  3. ncbi Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing
    L A Johnston
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 394:82-4. 1998
  4. ncbi The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition
    O C Sibon
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, New York, USA
    Curr Biol 9:302-12. 1999
  5. ncbi To differentiate or not to differentiate?
    D L Myster
    Department of Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    Curr Biol 10:R302-4. 2000
  6. pmc Spatial and temporal control of RNA stability
    A Bashirullah
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Proc Natl Acad Sci U S A 98:7025-8. 2001
  7. ncbi Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny
    T Isshiki
    Institute of Neuroscience Institute of Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
    Cell 106:511-21. 2001
  8. pmc Cell cycle roles for two 14-3-3 proteins during Drosophila development
    T T Su
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Sci 114:3445-54. 2001
  9. pmc Developmental and cell cycle regulation of the Drosophila histone locus body
    Anne E White
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Biol Cell 18:2491-502. 2007
  10. pmc Progression of the cell cycle through mitosis leads to abortion of nascent transcripts
    A W Shermoen
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448
    Cell 67:303-10. 1991

Research Grants

  1. Cell Cycle Regulation by Checkpoints in Drosophila
    Tin Tin Su; Fiscal Year: 2006
  2. Cell Growth and Radiation Survival in Drosophila
    Tin Tin Su; Fiscal Year: 2007
  3. An in vivo Screen for Radiation Sensitizers
    Tin Tin Su; Fiscal Year: 2008
  4. Molecular Genetics of Drosophila MAGUK's
    Peter Bryant; Fiscal Year: 2005
  5. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2006
  6. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2008
  7. SPECTRAL CONFOCAL MICROSCOPE
    Peter Bryant; Fiscal Year: 2002
  8. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  9. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
  10. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. ncbi A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
    J C de Nooij
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Cell 87:1237-47. 1996
    ..Thus, dap functions during embryogenesis to achieve a precisely timed exit from the cell cycle...
  2. ncbi Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25
    Achim Reber
    BZMB, Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
    Development 133:3201-11. 2006
    ..results in the premature degradation of the Cdk1 activators Cyclin B and Cyclin B3, and apparently of String/Cdc25 phosphatase as well. Without these activators, entry into terminal mitoses is not possible...
  3. ncbi Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing
    L A Johnston
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 394:82-4. 1998
    ..by inducing the proneural genes achaete and scute, which downregulate the mitosis-inducing phosphatase String (Cdc25)...
  4. ncbi The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition
    O C Sibon
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, New York, USA
    Curr Biol 9:302-12. 1999
    ....
  5. ncbi To differentiate or not to differentiate?
    D L Myster
    Department of Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    Curr Biol 10:R302-4. 2000
    ..Equally important is regulated withdrawal from the cell cycle to allow cells to differentiate. Recent evidence supports a direct link between transcriptional regulation of the cell cycle machinery and cell differentiation...
  6. pmc Spatial and temporal control of RNA stability
    A Bashirullah
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Proc Natl Acad Sci U S A 98:7025-8. 2001
    ..Similar mechanisms are likely to act later in development to restrict certain classes of transcripts to particular cell types within somatic cell lineages. Functions of transcript degradation and protection are discussed...
  7. ncbi Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny
    T Isshiki
    Institute of Neuroscience Institute of Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
    Cell 106:511-21. 2001
    ..We propose that Hunchback and Krüppel control early-born temporal identity in neuroblast cell lineages...
  8. pmc Cell cycle roles for two 14-3-3 proteins during Drosophila development
    T T Su
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Sci 114:3445-54. 2001
    ..Using mutants of cyclins, Cdk1 and Cdc25(string) to manipulate Cdk1 activity, we found that the localization of 14-3-3 proteins is coupled to Cdk1 activity ..
  9. pmc Developmental and cell cycle regulation of the Drosophila histone locus body
    Anne E White
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Biol Cell 18:2491-502. 2007
    ..HLB foci are present in histone deletion embryos, although the MPM-2 foci are smaller, and some Lsm11 foci are not associated with MPM-2 foci, suggesting that the histone locus is important for HLB integrity...
  10. pmc Progression of the cell cycle through mitosis leads to abortion of nascent transcripts
    A W Shermoen
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448
    Cell 67:303-10. 1991
    ..We conclude that progression through mitosis causes abortion of nascent transcripts and suggest that periodic abortion of transcription contributes to regulation of expression of large genes...
  11. ncbi Sensillum development in the absence of cell division: the sensillum phenotype of the Drosophila mutant string
    V Hartenstein
    Department of Biology, University of California San Diego, La Jolla 92093
    Dev Biol 138:147-58. 1990
    We have investigated sensillum development in Drosophila embryos homozygous for mutations in the locus string (stg). In these embryos, cell division is blocked following blastoderm formation...
  12. pmc The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string
    B A Edgar
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Cell 62:469-80. 1990
    The string (stg) locus of Drosophila encodes a factor that is thought to trigger mitosis by activating the p34cdc2 protein kinase...
  13. pmc Genetic control of cell division patterns in the Drosophila embryo
    B A Edgar
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Cell 57:177-87. 1989
    ..We describe the cloning of stg, and show that its predicted amino acid sequence is homologous to that of cdc25, a regular of mitotic initiation in the yeast S. pombe...
  14. ncbi Transposition of cloned P elements into Drosophila germ line chromosomes
    A C Spradling
    Science 218:341-7. 1982
    ..Thus P elements can efficiently and selectively transpose from extrachromosomal DNA to the DNA of germ line chromosomes in Drosophila embryos. These observations provide the basis for efficient DNA-mediated gene transfer in Drosophila...
  15. ncbi Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis
    B A Edgar
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Genes Dev 8:440-52. 1994
    The conserved regulators of cell cycle progression--Cyclins, Cdc2 kinase, and String phosphatase (Cdc25)--accommodate multiple modes of regulation during Drosophila embryogenesis...
  16. ncbi The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3187-95. 1995
    ..The asymmetric cortical localization of prospero at mitosis is a mechanism for rapidly establishing distinct sibling cell fates in the CNS and possibly other tissues...
  17. ncbi Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis
    K Sauer
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Germany
    Genes Dev 9:1327-39. 1995
    ..Observations in cyclin A mutants implicate G2 cyclins in this regulation. Our results suggest molecular explanations for the different rules governing S phase during mitotic and endoreduplication cycles...
  18. ncbi Cell cycle progression in the developing Drosophila eye: roughex encodes a novel protein required for the establishment of G1
    B J Thomas
    Department of Biological Chemistry, University of California, Los Angeles 90024
    Cell 77:1003-14. 1994
    ..e., Ras1 and Star). rux encodes a novel protein of 335 amino acids. We propose that rux functions as a negative regulator of G1 progression in the developing eye...
  19. pmc Synergistic action of Drosophila cyclins A and B during the G2-M transition
    J A Knoblich
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Germany
    EMBO J 12:65-74. 1993
    ..However, mitotic spindles are clearly abnormal and progression through mitosis is delayed in these cyclin B deficient embryos...
  20. pmc Cell cycling and patterned cell proliferation in the wing primordium of Drosophila
    M Milan
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Proc Natl Acad Sci U S A 93:640-5. 1996
    ..Cell cycle progression is linear rather than concentric. Clusters appear throughout the disc but with symmetries related to presumptive wing patterns, compartment boundaries, and vein clonal restrictions...
  21. ncbi A Cdc2 dependent checkpoint maintains diploidy in Drosophila
    S Hayashi
    National Institute of Genetics, Mishima, Shizuoka ken, Japan
    Development 122:1051-8. 1996
    ..These results suggest that in G2, escargot is required to maintain a high level of G2/M cdk that actively inhibits the entry into S phase...
  22. ncbi Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program
    B A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Genes Dev 10:1966-77. 1996
    ..Here we show that this transition requires degradation of two maternal mRNAs, string and twine, which encode Cdc25 phosphatases...
  23. pmc Cell cycling and patterned cell proliferation in the Drosophila wing during metamorphosis
    M Milan
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 93:11687-92. 1996
    ..The final number of cells of the wing is fixed independently of experimental perturbations that alter the cell division schedule. These results are discussed in the context of a model of wing morphogenesis...
  24. ncbi Developmental control of cell cycle regulators: a fly's perspective
    B A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 274:1646-52. 1996
    ....
  25. ncbi Induction of Drosophila eye development by decapentaplegic
    F Pignoni
    Howard Hughes Medical Institute, The School of Medicine, University of California, Los Angeles 90095, USA
    Development 124:271-8. 1997
    ..In addition, Dpp positively controls its own expression and suppresses wingless transcription. In contrast to the wing disc, Dpp does not appear to be the principal mediator of Hedgehog function in the eye...
  26. ncbi Coordination of growth and cell division in the Drosophila wing
    T P Neufeld
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 93:1183-93. 1998
    ..of the transcriptional regulator dE2F increased expression of the S- and M-phase initiators Cyclin E and String (Cdc25), thereby accelerating cell proliferation...
  27. pmc Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B
    H W Jacobs
    Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
    Genes Dev 12:3741-51. 1998
    ..However, both are required for female fertility and Cyclin B also for male fertility...
  28. ncbi Pattern formation in the absence of cell proliferation: tissue-specific regulation of cell cycle progression by string (stg) during Drosophila eye development
    B A Mozer
    Laboratory of Molecular Biology, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Building 36, Room 3D02, Bethesda, Maryland 20892, USA
    Dev Biol 213:54-69. 1999
    ..The cdc25 phosphatase string (stg) has been proposed to contribute to the synchronization of retinal precursors anterior to ..
  29. pmc Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis
    L Li
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210 USA
    Genes Dev 14:147-51. 2000
    ..pros activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes...
  30. ncbi A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila
    A Klebes
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Dusseldorf, 40225, Germany
    Curr Biol 10:76-85. 2000
    ..As previously shown, expression of just the short membrane-bound cytoplasmic domain is sufficient to rescue major defects associated with the loss of crumbs function...
  31. ncbi Activating the DNA damage checkpoint in a developmental context
    T T Su
    Campus Box 0347, MCD Biology, University of Colorado, Boulder, 80309, USA
    Curr Biol 10:119-26. 2000
    ..To understand the effects of checkpoint activation in a developmental context, we examined the effect of X-rays on post-blastoderm embryos of Drosophila melanogaster...
  32. ncbi Ras1 promotes cellular growth in the Drosophila wing
    D A Prober
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 100:435-46. 2000
    ..We propose that Ras primarily promotes growth and that growth is coupled to G1/S progression via cyclin E. Interestingly, upregulation of growth by Ras did not deregulate G2/M progression or a developmentally regulated cell cycle exit...
  33. ncbi Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation
    T C Seher
    Institute of Genetics, University of Cologne, Germany
    Curr Biol 10:623-9. 2000
    ..In particular, cell division is incompatible with certain types of morphogenetic cell behaviour, such as migration, adhesion and changes in cell shape. Mechanisms must therefore exist to ensure that one does not interfere with the other...
  34. ncbi A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila
    J Grosshans
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08540, USA
    Cell 101:523-31. 2000
    ..Here we describe a novel mitotic inhibitor that acts during Drosophila gastrulation to counteract String/Cdc25, specifically in the cells that invaginate to form the mesoderm...
  35. ncbi Cycling through development in Drosophila and other metazoa
    S J Vidwans
    Department of Biochemistry and Biophysics, University of California at San Francisco, California 94143 0448, USA
    Nat Cell Biol 3:E35-9. 2001
    ..Here we present the various modes of cell-cycle regulation in metazoa and discuss their possible generation by a combination of universally conserved molecules and new regulatory circuits...
  36. ncbi The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 104:699-708. 2001
    ..Through proliferation and survival control, such signals couple the total number of uncommitted cells being generated to the neural patterning of the retina...
  37. ncbi Endoreplication cell cycles: more for less
    B A Edgar
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, WA 98109, USA
    Cell 105:297-306. 2001
  38. ncbi Notch-Delta signaling induces a transition from mitotic cell cycle to endocycle in Drosophila follicle cells
    W M Deng
    Department of Biochemistry, University of Washington, J591, HSB, Seattle, WA 98195 7350, USA
    Development 128:4737-46. 2001
    ....
  39. ncbi Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression
    Claas A Meyer
    Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
    Development 129:319-28. 2002
    ..The dacapo regulatory region includes many independent cis-regulatory elements. The elements that control epidermal expression integrate developmental cues that time the arrest of cell proliferation...
  40. ncbi Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis
    Antonio Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 4:976-80. 2002
    ..mitotic wave' is triggered by EGFR signalling and depends on expression of String, the Drosophila homologue of Cdc25 phosphatase, the ultimate regulator of mitosis in all eukaryotic cells...
  41. ncbi Mitotic G2-arrest is required for neural cell fate determination in Drosophila
    Nicolas Negre
    Institut de Genetique Humaine, CNRS, 141 rue de la Cardonille, 34396 Cedex 5, Montpellier, France
    Mech Dev 120:253-65. 2003
    ..We forced G2 cells to enter mitosis by overexpression of string, the Drosophila homologue of the cdc25 gene. Premature entrance in the cell cycle is associated to a loss of precursor cells...
  42. ncbi Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells
    Valerie Schaeffer
    Department of Biochemistry, University of Washington, J591 Health Science Building, Seattle, WA 98195 7350, USA
    Curr Biol 14:630-6. 2004
    ..In this context, the only known cell cycle component that responds to the Notch pathway is String/Cdc25 (Stg), a G2/M cell cycle regulator...
  43. ncbi Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing
    Tânia Reis
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cell 117:253-64. 2004
    ..dE2F1, in turn, positively regulates cyclin E and string/cdc25, which activate the Cdks to drive cell cycle progression...
  44. ncbi Regulation of temporal identity transitions in Drosophila neuroblasts
    Ruth Grosskortenhaus
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Dev Cell 8:193-202. 2005
    ..We conclude that two distinct "timers" regulate neuroblast gene expression: a hunchback --> Kruppel timer requiring cytokinesis, and a Kruppel --> pdm1 --> castor timer which is cell cycle independent...
  45. pmc Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells
    Jianjun Sun
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    Development 132:4299-308. 2005
    ..Our data suggest that Cut functions in regulating both cell differentiation and the cell cycle, and that downregulation of Cut by Notch contributes to the mitotic cycle/endocycle switch and cell differentiation in follicle cells...
  46. ncbi Connecting cancer to the asymmetric division of stem cells
    Andreas Wodarz
    Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain CMPB, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Cell 124:1121-3. 2006
    ..This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis...
  47. pmc Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity
    Brent S Wells
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Biol 16:1606-15. 2006
    ..Here we provide evidence that Drosophila p53 (dp53) has a previously unidentified role in coordinating the compensatory growth response to tissue damage...
  48. pmc Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control
    Yuri M Moshkin
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 27:651-61. 2007
    ..BAP mediates G(2)/M transition through direct regulation of string/cdc25. Its signature subunit, OSA, is required for directing BAP to the string/cdc25 promoter...
  49. ncbi Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis
    Shusaku Shibutani
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Development 134:467-78. 2007
    ..E2f1 protein reaccumulates in epidermal cells arrested in G1(17), and in these cells the induction of p27(Dap) activates Rbf1 to repress E2f1-target genes to maintain a stable G1 arrest...
  50. ncbi Multiple protein phosphatases are required for mitosis in Drosophila
    Feng Chen
    Cancer Research United Kingdom, Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Curr Biol 17:293-303. 2007
    ..Approximately one-third of the Drosophila kinome has been ascribed some cell-cycle function. However, little is known about which of its 117 protein phosphatases (PPs) or subunits have counteracting roles...
  51. ncbi A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila
    Laura A Buttitta
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 12:631-43. 2007
    ..In other cell types, however (e.g., wing epithelial cells), unknown mechanisms inhibit E2F and Cyclin/Cdk activity in parallel to enforce permanent cell cycle exit upon terminal differentiation...
  52. pmc Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent
    Jennifer Jemc
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Dev Biol 310:416-29. 2007
    ..Among the targets identified by our analysis was the cell cycle regulatory gene, string (stg), suggesting that EYA and SO may influence cell proliferation through transcriptional regulation of stg...
  53. pmc The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles
    Norman Zielke
    University of Cologne, Institute for Genetics, 50674 Koln, Germany
    Genes Dev 22:1690-703. 2008
    ..Geminin is only abundant in cells with high CycE-Cdk2 activity, suggesting that APC/C-Fzr activity is periodically inhibited by CycE-Cdk2, to prevent relicensing in S-phase cells...
  54. pmc The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye
    Abhishek Bhattacharya
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 327:288-300. 2009
    ..A model is proposed in which Extramacrochaetae acts in parallel to or as a feed-forward regulator of the E(spl)-Complex to promote Notch signaling in particular cellular contexts...
  55. doi Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1
    Ralf B Schittenhelm
    Institute of Molecular Life Sciences, University of Zurich, CH 8057 Zurich, Switzerland
    J Cell Sci 123:3768-79. 2010
    ..We demonstrate that the low amount of endogenous Cal1 prevents centromere expansion and mitotic kinetochore failure when Cenp-A/Cid and Cenp-C are present in excess...
  56. pmc String (Cdc25) regulates stem cell maintenance, proliferation and aging in Drosophila testis
    Mayu Inaba
    Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 138:5079-86. 2011
    ..Here, we show that the Cdc25 homolog String (Stg) is a crucial regulator of germline stem cells (GSCs) and cyst stem cells (CySCs) in ..
  57. ncbi Degradation of maternal string mRNA is controlled by proteins encoded on maternally contributed transcripts
    F A Myers
    Biophysics Laboratory, University of Portsmouth, UK
    Mech Dev 51:217-26. 1995
    ..Therefore, the proteins required to activate the degradation of string mRNA are encoded on a maternally contributed mRNA. We discuss possible models to explain the degradation pathway...
  58. ncbi Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
    J A Knoblich
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    Cell 77:107-20. 1994
    ..Therefore, Drosophila cyclin E, which forms a complex with the Dmcdc2c kinase, controls progression through S phase and its down-regulation limits embryonic proliferation...
  59. ncbi Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos
    I A Dawson
    Department of Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536 0812
    Development 117:359-76. 1993
    ..These results demonstrate that fizzy is a cell cycle mutation and that the normal function of the fizzy gene is required for dividing cells to exit metaphase and complete mitosis...
  60. ncbi DNA-replication checkpoint control at the Drosophila midblastula transition
    O C Sibon
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, 11794 5215, USA
    Nature 388:93-7. 1997
    ..This delay may allow both completion of S phase and transcription of genes that initiate the switch to zygotic control of embryogenesis...
  61. ncbi Imaginal tissues of Drosophila melanogaster exhibit different modes of cell proliferation control
    P Kylsten
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Sweden
    Dev Biol 192:509-22. 1997
    ..We show that G2-phase arrest in late larval wing imaginal disks requires transcriptional control of stg, a mitotic inducer that encodes a D. melanogaster homologue of the Schizosaccharomyces pombe p80cdc25 phosphatase...
  62. ncbi Cis-regulatory elements of the mitotic regulator, string/Cdc25
    D A Lehman
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 126:1793-803. 1999
    Mitosis in most Drosophila cells is triggered by brief bursts of transcription of string (stg), a Cdc25-type phosphatase that activates the mitotic kinase, Cdk1 (Cdc2)...
  63. pmc Joint action of two RNA degradation pathways controls the timing of maternal transcript elimination at the midblastula transition in Drosophila melanogaster
    A Bashirullah
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    EMBO J 18:2610-20. 1999
    ..The second pathway is activated 2 h after fertilization and functions together with the maternal pathway to ensure that transcripts are degraded by the MBT...
  64. ncbi The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions
    Halyna R Shcherbata
    Department of Biochemistry, University of Washington, J591, HSB, Seattle, WA 98195 7350, USA
    Development 131:3169-81. 2004
    ..These genes include the G2/M regulator Cdc25 phosphatase, String; a regulator of the APC ubiquitination complex Hec/CdhFzr and an inhibitor of the CyclinE/CDK ..
  65. ncbi Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome
    Manolo Bellotto
    Zoologisches Institut der Universitat Zurich, Switzerland
    Int J Dev Biol 46:149-57. 2002
    ....
  66. pmc A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila
    Duarte Mesquita
    Institute for Research in Biomedicine, Barcelona, Spain
    PLoS Biol 8:e1000566. 2010
    ....
  67. pmc Embryonic onset of late replication requires Cdc25 down-regulation
    Jeffrey A Farrell
    Department of Biochemistry, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 26:714-25. 2012
    ..At the MBT, down-regulation of Cdc25 phosphatase and the resulting inhibitory phosphorylation of the mitotic kinase Cdk1 create a G2 pause in ..
  68. ncbi Role of the zygotic genome in the restructuring of the actin cytoskeleton at the cycle-14 transition during Drosophila embryogenesis
    E D Schejter
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Cold Spring Harb Symp Quant Biol 57:653-9. 1992
  69. ncbi twine, a cdc25 homolog that functions in the male and female germline of Drosophila
    L Alphey
    Department of Biochemistry, The University, Dundee, Scotland
    Cell 69:977-88. 1992
    twine is the second homolog of the fission yeast gene cdc25 to be found in Drosophila. Both string and twine cDNAs can rescue a temperature-sensitive cdc25 mutation in fission yeast, but not a deletion...
  70. ncbi Cell shape changes during gastrulation in Drosophila
    M Leptin
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, West Germany
    Development 110:73-84. 1990
    ..Finally, we show that the region where the ventral furrow forms is determined by the expression of mesoderm-specific genes, and not by mechanical or other epigenetic properties of the egg...
  71. ncbi Drosophila development pulls the strings of the cell cycle
    B H Reed
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Bioessays 17:553-6. 1995
    ..by the string gene is a positive regulator of cdc2 kinase and a Drosophila homologue of the Saccharomyces pombe cdc25 tyrosine phosphatase...
  72. ncbi The role of the cell cycle and cytokinesis in regulating neuroblast sublineage gene expression in the Drosophila CNS
    X Cui
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3233-43. 1995
    ..These results suggest that neuroblasts have an intrinsic gene regulatory hierarchy controlling unplugged and achaete expression, but that cell cycle- or cytokinesis-dependent mechanisms are required for ming and eve CNS expression...
  73. ncbi Cell cycle. Cell-cycle control in a developmental context
    B A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Curr Biol 4:522-4. 1994
    ..Down-regulation of a cyclin specific to the G1 phase of the cell cycle, cyclin E, terminates the initial period of cell proliferation in developing Drosophila embryos...
  74. ncbi The dominant Drop eye mutations of Drosophila melanogaster define two loci implicated in normal eye development
    R Tearle
    Department of Biochemistry, Adelaide University, Australia
    Mol Gen Genet 244:426-34. 1994
    ....
  75. ncbi Expression of protein tyrosine phosphatase genes during oogenesis in Drosophila melanogaster
    K A Fitzpatrick
    Institute of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    Mech Dev 53:171-83. 1995
    ..DPTP69D transcripts are sequestered in the nucleus from stage 7 to stage 10, and then released to the cytoplasm. Our observations suggest that the export of DPTP69D mRNA from the nucleus is temporally regulated during oogenesis...
  76. pmc A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo
    S Hayashi
    Department of Molecular Biology, Princeton University, NJ 08540, USA
    Proc Natl Acad Sci U S A 94:242-7. 1997
    ..As observed in the rodent, high levels of D-APC expression have been detected in the central nervous system, suggesting a role for D-APC in central nervous system formation...
  77. pmc Size control: cell proliferation does not equal growth
    T T Su
    Department of Biochemistry and Biophysics, University of California San Francisco 94143 0448, USA
    Curr Biol 8:R687-9. 1998
    ..Both classic and recent experiments confirm this simple rationale: altering proliferation produces normally sized body structures with either especially small or exceptionally large cells...
  78. ncbi Who pulls the string to pattern cell division in Drosophila?
    H Skaer
    Developmental Genetics Programme, Krebs Institute, University of Sheffield, UK
    Trends Genet 14:337-9. 1998
  79. ncbi Hox genes differentially regulate Serrate to generate segment-specific structures
    E L Wiellette
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    Development 126:1985-95. 1999
    ..However, Serrate does not require rhomboid function in the maxillary segment, suggesting that the Hox-Serrate pathway to segment-specific morphogenesis can be linked to more than one downstream function...
  80. pmc Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes
    E Foley
    Institut fur Genetik, Universitat zu Koln, Koln, D 50931, Germany
    Curr Biol 9:1392-402. 1999
    ..Rux has no homology to known Cdk inhibitors (CKIs), and the molecular mechanism of Rux function is not known...
  81. ncbi Cell behaviour of Drosophila fat cadherin mutations in wing development
    F Garoia
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Italy
    Mech Dev 94:95-109. 2000
    ..Mutant ft cells show, in addition, smaller cell sizes during proliferation and abnormal cuticular differentiation, which reflect cell membrane and cytoskeleton anomalies, which are not modulated by the DER pathway...
  82. ncbi The CNS midline cells coordinate proper cell cycle progression and identity determination of the Drosophila ventral neuroectoderm
    J Chang
    Department of Chemistry, Konkuk University, Seoul, 143 701, Korea
    Dev Biol 227:307-23. 2000
    ..This study indicates that the CNS midline cells play important roles in the coordination of the proper cell cycle progression and the correct identity determination of the adjacent ventral neuroectoderm along the dorsoventral axis...
  83. ncbi The Snail protein family regulates neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila
    S I Ashraf
    Program in Molecular Medicine and Department of Cell Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Development 128:4757-67. 2001
    ..These results suggest that the Snail family of proteins control both asymmetry and cell division of neuroblasts by activating, probably indirectly, the expression of inscuteable and string...
  84. ncbi [Phase-specific elements of the regulatory zone of the Drosophila melanogaster string gene]
    S A Trunova
    Institute of Cytology and Genetics, Russian Academy of Science, Novosibirsk, 630090 Russia
    Genetika 37:1616-20. 2001
    The phases of the reporter gene expression controlled by different fragments of the string (stg) gene regulatory region were determined in Drosophila neuroblasts by detection of beta-galactosidase activity and radioautography...
  85. pmc Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos
    Smruti J Vidwans
    Department of Biochemistry and Biophysics, University of California, San Francisco, Box 0448, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Curr Biol 12:829-33. 2002
    ....
  86. ncbi The formation of sense organs in Drosophila: a logical approach
    Alain Ghysen
    Laboratoire de Neurogénétique, Universite Montpellier II, France
    Bioessays 25:802-7. 2003
    ..e., of its possible evolutions and of its reactions to fluctuations and perturbations...
  87. ncbi The Drosophila RCC1 homolog, Bj1, regulates nucleocytoplasmic transport and neural differentiation during Drosophila development
    Wei Yang Shi
    Program in Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 270:106-21. 2004
    ..Finally, we show that dRCC1 is required for cell proliferation and/or survival during germline, eye and wing development and that dRCC1 appears to facilitate apoptosis...
  88. ncbi string(cdc25) and cyclin E are required for patterned histone expression at different stages of Drosophila embryonic development
    David J Lanzotti
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Biol 274:82-93. 2004
    ..In post-blastoderm Drosophila embryos, zygotic expression of the stg(cdc25) phosphatase in G2 activates cyclin/cdc2 kinases and triggers mitosis...
  89. pmc The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins
    Pawel Gawlinski
    ZMBH, Im Neuenheimer Feld 282, Heidelberg 69120, Germany
    EMBO Rep 8:490-6. 2007
    ..We propose that binding of Frs to cyclins blocks the hydrophobic patch to interfere with Cdk1 substrate recognition...
  90. doi Negative-feedback regulation of proneural proteins controls the timing of neural precursor division
    Pao Ju Chang
    Department of Life Science, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan 333, Taiwan
    Development 135:3021-30. 2008
    ..As phyl is a direct transcriptional target of Ac and Sc, our data suggest that, in addition to mediating cell cycle arrest, proneural protein initiates a negative-feedback regulation to time the mitotic entry of neural precursors...
  91. doi Notch signalling coordinates tissue growth and wing fate specification in Drosophila
    Neus Rafel
    ICREA and Institute for Research in Biomedicine IRB Científic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
    Development 135:3995-4001. 2008
    ..These results highlight a crucial role of Notch in linking proliferation and fate specification in the developing wing primordium...
  92. doi Regulation of cell proliferation and wing development by Drosophila SIN3 and String
    Aishwarya Swaminathan
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mech Dev 127:96-106. 2010
    ..SIN3 affects normal cell growth and leads to down regulation of expression of the cell cycle regulator gene String (STG)...
  93. ncbi Blocking cell division does not remove the requirement for Polycomb function in Drosophila embryogenesis
    A P Gould
    Department of Anatomy, University of Cambridge, UK
    Development 110:1319-25. 1990
    ..Thus, even in the absence of DNA replication, Pc is required to maintain spatially restricted patterns of homeotic gene expression. The role of the Pc gene product in the stable repression of homeotic gene transcription is discussed...
  94. pmc Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string
    J Jimenez
    Department of Biochemistry, University of Oxford, UK
    EMBO J 9:3565-71. 1990
    ..This library was introduced into S.pombe cdc2 and cdc25 mutants, and plasmids isolated carrying cDNAs that complement these mutations...
  95. ncbi Abbreviated and regulated cell cycles in Drosophila
    D M Glover
    Department of Biochemistry, University of Dundee, Scotland
    Curr Opin Cell Biol 2:258-61. 1990
  96. ncbi Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector
    E Bier
    Howard Hughes Medical Institute, San Francisco, California
    Genes Dev 3:1273-87. 1989
    ..This type of screen appears to be an effective way to find new loci that may play a role in the development of the Drosophila nervous system...
  97. ncbi Distribution of swallow protein in egg chambers and embryos of Drosophila melanogaster
    J Hegde
    Department of Biology, University of Rochester, NY 14627
    Development 119:457-70. 1993
    ....
  98. ncbi Singling out the tip cell of the Malpighian tubules--lessons from neurogenesis
    A S Wilkins
    Company of Biologists, Ltd, Cambridge, UK
    Bioessays 17:199-202. 1995
    ..Beyond these similarities between neural development and tip cell selection, the later differentiation of the tip cell shows some intriguing elements of neural cell differentiation...
  99. ncbi Growth and differentiation in the Drosophila eye coordinated by hedgehog
    U Heberlein
    Department of Neurology and Program in Neuroscience, University of California, San Francisco
    Nature 373:709-11. 1995
    ..We propose that the morphogenetic furrow coincides with a transient boundary that coordinates growth and differentiation of the eye disc, and that hedgehog is necessary and sufficient to propagate this boundary across the epithelium...
  100. ncbi Transcriptional control and signal transduction: of soap-operas and reductionism
    W S Dynan
    Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309 0215
    Trends Genet 9:154-6. 1993

Research Grants15

  1. Cell Cycle Regulation by Checkpoints in Drosophila
    Tin Tin Su; Fiscal Year: 2006
    ..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..
  2. Cell Growth and Radiation Survival in Drosophila
    Tin Tin Su; Fiscal Year: 2007
    ..Understanding radiation survival in a multicellular context could help identify potential therapies for when we do not want cells to survive irradiation, such as in the treatment of cancer. ..
  3. An in vivo Screen for Radiation Sensitizers
    Tin Tin Su; Fiscal Year: 2008
    ..Successful completion of this project would establish a novel, rapid and effective primary screen in vivo for radiosensitizers with potential therapeutic value. [unreadable] [unreadable] [unreadable]..
  4. Molecular Genetics of Drosophila MAGUK's
    Peter Bryant; Fiscal Year: 2005
    ..The work will provide a genetic approach to understanding the functions of Dlg and its mammalian homologs, some of which are strongly implicated in a variety of human cancers. ..
  5. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2006
    ..abstract_text> ..
  6. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2008
    ....
  7. SPECTRAL CONFOCAL MICROSCOPE
    Peter Bryant; Fiscal Year: 2002
    ..abstract_text> ..
  8. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ..Other PTPases have been shown to have important effects on cellular growth control. PTPases such as cdc25 and MKP-1 have very specific intracellular substrates, cdc-2, Map kinase, respectively, thus establishing their ..
  9. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  10. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  11. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. [unreadable] [unreadable]..
  12. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  14. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..