tra

Summary

Gene Symbol: tra
Description: transformer
Alias: CG16724, Dmel\CG16724, Dmtra, TRA, Tra, CG16724 gene product from transcript CG16724-RA, CG16724-PA, CG16724-PB, tra-PA, tra-PB
Species: fruit fly

Top Publications

  1. ncbi Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior
    K D Finley
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, San Diego, California 92186, USA
    Neuron 21:1363-74. 1998
  2. ncbi Mushroom bodies are not required for courtship behavior by normal and sexually mosaic Drosophila
    Asami Kido
    National Institute for Basic Biology, Myodaiji, Okazaki, Aichi 444 8585, Japan
    J Neurobiol 52:302-11. 2002
  3. ncbi Neural circuitry that governs Drosophila male courtship behavior
    Petra Stockinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:795-807. 2005
  4. pmc Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster
    Elizabeth J Rideout
    Faculty of Biomedical and Life Sciences, Integrative and Systems Biology, University of Glasgow, Glasgow, UK
    Nat Neurosci 13:458-66. 2010
  5. ncbi Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila
    K Hoshijima
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Science 252:833-6. 1991
  6. ncbi Genetic feminization of brain structures and changed sexual orientation in male Drosophila
    J F Ferveur
    Department of Biology, New York University, NY 10003
    Science 267:902-5. 1995
  7. ncbi Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer
    K W Lynch
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 10:2089-101. 1996
  8. pmc Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila
    Yesser Hadj Belgacem
    Bases Neurales du Mouvement chez la Drosophile, Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8620, Universite Paris Sud, F 91405 Orsay, France
    Proc Natl Acad Sci U S A 99:15154-8. 2002
  9. ncbi Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene
    L C Ryner
    Department of Biological Sciences, Stanford University, California 94305, USA
    Cell 87:1079-89. 1996
  10. ncbi The remarkable ubiquity of DM domain factors as regulators of sexual phenotype: ancestry or aptitude?
    Jonathan Hodgkin
    Genetics Unit, Department of Biochemistry, University of Oxford, OX1 3QU, UK
    Genes Dev 16:2322-6. 2002

Research Grants

Scientific Experts

Detail Information

Publications128 found, 100 shown here

  1. ncbi Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior
    K D Finley
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, San Diego, California 92186, USA
    Neuron 21:1363-74. 1998
    ..Expression of a female transformer cDNA under the control of a dsf enhancer in males leads to dsf-like bisexual behavior...
  2. ncbi Mushroom bodies are not required for courtship behavior by normal and sexually mosaic Drosophila
    Asami Kido
    National Institute for Basic Biology, Myodaiji, Okazaki, Aichi 444 8585, Japan
    J Neurobiol 52:302-11. 2002
    ..Thus, contrary to previous assumptions, the mushroom bodies are not required for the control of courtship. Present evidence supports its mediation by other distributed protocerebral regions...
  3. ncbi Neural circuitry that governs Drosophila male courtship behavior
    Petra Stockinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:795-807. 2005
    ..This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent...
  4. pmc Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster
    Elizabeth J Rideout
    Faculty of Biomedical and Life Sciences, Integrative and Systems Biology, University of Glasgow, Glasgow, UK
    Nat Neurosci 13:458-66. 2010
    ..We found that disrupting dsx neuronal function had profound effects on male sexual behavior. Furthermore, our results suggest that dsx-positive neurons are involved in pre- to post-copulatory female reproductive behaviors...
  5. ncbi Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila
    K Hoshijima
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Science 252:833-6. 1991
    ..Cotransfection analyses in which the dsx gene and the female-specific transformer (tra) and transformer-2 (tra-2) complementary DNAs were expressed in Drosophila Kc cells revealed that female-specific ..
  6. ncbi Genetic feminization of brain structures and changed sexual orientation in male Drosophila
    J F Ferveur
    Department of Biology, New York University, NY 10003
    Science 267:902-5. 1995
    ..These two brain structures, both of which are involved in olfactory processing, may function in the recognition of sex-specific pheromones, in the control of sex-specific behaviors, or both...
  7. ncbi Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer
    K W Lynch
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 10:2089-101. 1996
    ..Here, we show that the Drosophila regulatory proteins Transformer (Tra) and Transformer 2 (Tra2) recruit different members of the SR family of splicing factors to the repeats and the PRE...
  8. pmc Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila
    Yesser Hadj Belgacem
    Bases Neurales du Mouvement chez la Drosophile, Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8620, Universite Paris Sud, F 91405 Orsay, France
    Proc Natl Acad Sci U S A 99:15154-8. 2002
    ....
  9. ncbi Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene
    L C Ryner
    Department of Biological Sciences, Stanford University, California 94305, USA
    Cell 87:1079-89. 1996
    ....
  10. ncbi The remarkable ubiquity of DM domain factors as regulators of sexual phenotype: ancestry or aptitude?
    Jonathan Hodgkin
    Genetics Unit, Department of Biochemistry, University of Oxford, OX1 3QU, UK
    Genes Dev 16:2322-6. 2002
  11. ncbi The Drosophila melanogaster gene lethal(3)73Ah encodes a ring finger protein homologous to the oncoproteins MEL-18 and BMI-1
    I Irminger-Finger
    Department of Biochemistry, University of Geneva, Switzerland
    Gene 163:203-8. 1995
    ..Its transcription is temporally and spatially regulated with maximal expression in adult females. In all stages the mRNA can be localized to the fat body and, in addition, to the ovaries of adult females...
  12. pmc The sex-determination genes fruitless and doublesex specify a neural substrate required for courtship song
    Elizabeth J Rideout
    Division of Molecular Genetics, University of Glasgow, Anderson College, Glasgow, UK
    Curr Biol 17:1473-8. 2007
    ....
  13. pmc RNA binding by Sxl proteins in vitro and in vivo
    M E Samuels
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Mol Cell Biol 14:4975-90. 1994
    ..MBP-Sxl formed two shifted complexes on a tra regulated acceptor site RNA; the doubly shifted form may have been stabilized by protein-protein interactions...
  14. pmc Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing
    K Inoue
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Proc Natl Acad Sci U S A 89:8092-6. 1992
    ..UV-crosslinking experiments revealed that both female-specific transformer (tra) and transformer-2 (tra-2) products bind to the 13-nucleotide sequences of dsx pre-mRNA...
  15. ncbi Moving up the hierarchy: a hypothesis on the evolution of a genetic sex determination pathway
    A S Wilkins
    Company of Biologists, Ltd, New Museums Site, University of Cambridge, UK
    Bioessays 17:71-7. 1995
    ..Finally, the specific molecular and population genetic questions that the model raises are described and some tests are proposed...
  16. ncbi The evolutionary dynamics of sex determination
    I Marin
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Science 281:1990-4. 1998
    ....
  17. ncbi Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases
    B J Blencowe
    Dept of Medical Research, C H Best Institute, University of Toronto, 112 College St, Toronto, Ontario, Canada M5G 1L6
    Trends Biochem Sci 25:106-10. 2000
    ..Ominously, these latter studies predict that many human genetic diseases linked to mutations within exons might be caused by the inactivation of ESEs...
  18. ncbi Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation
    L C Ryner
    Department of Biological Sciences, Stanford University, California 94305
    Genes Dev 5:2071-85. 1991
    ..results from the utilization of an upstream 3'-terminal exon and requires the activities of both the transformer (tra) and transformer-2 (tra-2) genes...
  19. ncbi A splicing enhancer exhibits both constitutive and regulated activities
    M Tian
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 8:1703-12. 1994
    The Drosophila proteins Transformer (Tra) and Transformer2 (Tra2) regulate the sex-specific alternative splicing of Drosophila doublesex (dsx) pre-mRNA by specifically binding to a splicing enhancer (dsx repeat element; dsxRE) located ..
  20. ncbi Behavioral and neurobiological implications of sex-determining factors in Drosophila
    B J Taylor
    Department of Zoology, Oregon State University, Corvallis
    Dev Genet 15:275-96. 1994
    ....
  21. pmc dissatisfaction, a gene involved in sex-specific behavior and neural development of Drosophila melanogaster
    K D Finley
    Molecular Biology and Virology Laboratory, The Salk Institute, San Diego, CA 92186, USA
    Proc Natl Acad Sci U S A 94:913-8. 1997
    ..Epistasis experiments show that dsf acts in a tra-dependent and dsx-independent manner, placing dsf in the dsx-independent portion of the sex determination cascade.
  22. ncbi The pheromonal role of cuticular hydrocarbons in Drosophila melanogaster
    J F Ferveur
    Mecanismes de Communication, NAM4, URA CNRS 1491, Batiment 446, Universite Paris Sud, Orsay, France
    Bioessays 19:353-8. 1997
    ..Recent exploration of these interspecific variations, and of intraspecific variations, has led to the characterization of genes and to the mapping of structures that process the production and perception of chemical messages...
  23. pmc Analysis of the functional specificity of RS domains in vivo
    B Dauwalder
    Department of Molecular Genetics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 45, Houston, TX 77030, USA
    EMBO J 17:6049-60. 1998
    ..domains from several proteins to substitute in vivo for an essential RS domain in the Drosophila splicing regulator TRA-2...
  24. ncbi Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression
    K Usui-Aoki
    School of Human Sciences and Advanced Research Institute for Science and Engineering, Waseda University, 2 579 15, Mikajima, Tokorozawa 359 1192, Japan
    Nat Cell Biol 2:500-6. 2000
    ..fru gene encodes a putative transcription factor with a BTB domain and two zinc-finger motifs, and with consensus Tra-binding sequences...
  25. ncbi Median bundle neurons coordinate behaviours during Drosophila male courtship
    Devanand S Manoli
    Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Nature 430:564-9. 2004
    ..Our results identify a small group of median bundle neurons, that in wild-type Drosophila appropriately trigger the sequential execution of the component behaviours that constitute the Drosophila courtship ritual...
  26. ncbi Control of male sexual behavior in Drosophila by the sex determination pathway
    Jean Christophe Billeter
    IBLS Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK
    Curr Biol 16:R766-76. 2006
    ....
  27. pmc A role for the adult fat body in Drosophila male courtship behavior
    Anna A Lazareva
    Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States of America
    PLoS Genet 3:e16. 2007
    ..In support of this idea, we demonstrate that Takeout, a protein known to influence mating, is present in the hemolymph of adult males but not females and acts as a secreted protein...
  28. ncbi Positive control of pre-mRNA splicing in vitro
    M Tian
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138
    Science 256:237-40. 1992
    ..melanogaster involves the activation of a female-specific 3' splice site by the products of the transformer (tra) and transformer-2 (tra-2) genes...
  29. ncbi Commitment of abdominal neuroblasts in Drosophila to a male or female fate is dependent on genes of the sex-determining hierarchy
    B J Taylor
    Department of Zoology, University of Washington, Seattle 98195
    Development 114:625-42. 1992
    ..The time when neuroblasts become committed to generate their sex-specific divisions were identified by shifting tra-2ts flies between the male- and female-specifying temperatures at various times during larval development...
  30. ncbi Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript
    K Inoue
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Nature 344:461-3. 1990
    ..functional female-specific splicing of the transcripts of the immediately downstream regulatory gene, transformer (tra). The first exon of the tra primary transcript is spliced to one of two acceptor sites...
  31. ncbi Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila
    L R Bell
    Department of Biology, Princeton University, New Jersey 08544
    Cell 65:229-39. 1991
    ..We conclude that the female determined state is maintained by Sxl through positive autoregulation, while the male determined state is maintained by default...
  32. ncbi Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene
    R T Boggs
    Cell 50:739-47. 1987
    The transformer (tra) gene regulates female somatic sexual differentiation and has no known function in males. It gives rise to two sizes of RNA, one non-sex-specific and one female-specific...
  33. ncbi Ectopic expression of the female transformer gene product leads to female differentiation of chromosomally male Drosophila
    M McKeown
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138
    Cell 53:887-95. 1988
    The transformer (tra) gene of Drosophila is necessary for all aspects of female somatic sexual differentiation. tra uses a single set of precursor RNAs to produce female- and non-sex-specific RNAs by alternative splicing...
  34. pmc The sex-determining gene tra of Drosophila: molecular cloning and transformation studies
    B Butler
    EMBO J 5:3607-13. 1986
    ..is read by a key gene (Sxl) and transmitted down to the differentiation genes by the subordinate control genes tra, tra-2, ix and dsx. Mutations in tra transform chromosomal females (X/X; tra/tra) into sterile males (pseudomales)...
  35. ncbi A molecular analysis of transformer, a gene in Drosophila melanogaster that controls female sexual differentiation
    M McKeown
    Cell 48:489-99. 1987
    The transformer (tra) gene regulates all aspects of somatic sexual differentiation in Drosophila melanogaster females and has no function in males. We have isolated the tra gene as part of a 200 kb chromosomal walk...
  36. ncbi The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster
    R N Nagoshi
    Department of Biological Sciences, Stanford University, California 94305
    Cell 53:229-36. 1988
    The transformer (tra) and doublesex (dsx) genes produce sex-specific transcripts that are generated by differential RNA processing...
  37. pmc Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster
    B S Baker
    Genetics 94:383-423. 1980
    ..is under the control of the X chromosome:autosome ratio and at least four major regulatory genes: transformer (tra), transformer-2 (tra-2), doublesex (dsx) and intersex (ix)...
  38. ncbi Functional dissection of the Drosophila mushroom bodies by selective feminization of genetically defined subcompartments
    K M O'Dell
    Laboratory of Genetics, University of Glasgow, Scotland
    Neuron 15:55-61. 1995
    ..Expression of transformer in other mushroom body domains, and in control lines, has no such effect. Our data support the view that genetically defined subsets of mushroom body intrinsic neurons perform different functional roles...
  39. ncbi The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA
    J Valcarcel
    Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605
    Nature 362:171-5. 1993
    ..The protein Sex-lethal (Sxl) activates a female-specific 3' splice site in the first intron of transformer (tra) pre-mRNA while repressing an alternative non-sex-specific site...
  40. ncbi The regulation of the yolk protein genes, a family of sex differentiation genes in Drosophila melanogaster
    M Bownes
    Division of Biological Sciences, University of Edinburgh, UK
    Bioessays 16:745-52. 1994
    ....
  41. ncbi The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2
    H Amrein
    Howard Hughes Medical Institute, Columbia University, New York, New York 10032
    Cell 76:735-46. 1994
    ..These results demonstrate that both protein-RNA and protein-protein interactions are involved in tra2-dependent activation and repression of alternative splicing...
  42. ncbi The mating of a fly
    J C Hall
    Department of Biology, Brandeis University, Waltham, MA 02254 9110
    Science 264:1702-14. 1994
    ..Further behavioral mutations seemed originally to be courtship-specific, turned out not to have that property, and have led to a broadened perspective on the nature and action of Drosophila's sex-determination genes...
  43. ncbi The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila
    A Hilfiker
    Zoological Institute, University of Zurich, Switzerland
    Development 121:4017-26. 1995
    ..They have male-specifically spliced mRNA of tra, and when rescued by msl, also of Sxl...
  44. ncbi Simultaneous influence on male courtship of stimulatory and inhibitory pheromones produced by live sex-mosaic Drosophila melanogaster
    J F Ferveur
    U R A CNRS 1491, Universite Paris Sud, Orsay, France
    Proc Biol Sci 263:967-73. 1996
    ..The influence of secondary molecules on male behaviours was also evaluated. The role of these substances is discussed with regard to their structure, sexual specificity, and evolutionary function...
  45. ncbi Vive la différence: males vs females in flies vs worms
    T W Cline
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Annu Rev Genet 30:637-702. 1996
    ..Although no overlap has been found among the molecules used by flies and worms to achieve sex determination, striking similarities have been found in the genetic strategies used by these two species to differentiate their sexes...
  46. ncbi The gene fl(2)d is needed for the sex-specific splicing of transformer pre-mRNA but not for double-sex pre-mRNA in Drosophila melanogaster
    B Granadino
    Centro de Investigaciones Biologicas, Madrid, Spain
    Mol Gen Genet 253:26-31. 1996
    ..The first gene is Sex-lethal(Sxl). The downstream target of Sxl is the gene transformer (tra): the Sxl protein controls the female-specific splicing of the Tra pre-mRNA...
  47. ncbi Genetic feminization of pheromones and its behavioral consequences in Drosophila males
    J F Ferveur
    Mecanismes de Communication, Unité de Recherche Associée CNRS 1491, Batiment 446, Universite Paris Sud, 91405, Orsay Cedex, France
    Science 276:1555-8. 1997
    ..The resulting flies generally exhibited male heterosexual orientation but elicited homosexual courtship from other males...
  48. pmc Regulation of sex-specific selection of fruitless 5' splice sites by transformer and transformer-2
    V Heinrichs
    Department of Biological Sciences, Stanford University, California 94305 5020, USA
    Mol Cell Biol 18:450-8. 1998
    ..Here we report that the Drosophila sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern ..
  49. ncbi Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica
    M Meise
    Zoological Institute, University of Zurich Irchel, Zurich, Switzerland
    Development 125:1487-94. 1998
    ..Peluso, I., Artiaco, D. , Giodano, E., Bopp, D. and Polito, L. C. (1998) Development 125, 1495-1500) suggesting that, in these non-drosophilid species, Sxl performs a function different from that in sex determination...
  50. ncbi The function of multisite splicing enhancers
    K J Hertel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell 1:449-55. 1998
    ..Thus, the function of multisite enhancer elements to increase the probability of an interaction between the enhancer complex and the splicing machinery rather than to promote functional synergy...
  51. ncbi Sexual behaviour in Drosophila is irreversibly programmed during a critical period
    B I Arthur
    Zoological Institute University of Zurich Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 8:1187-90. 1998
    ..One sex-determining gene is transformer (tra), the activity of which is needed for female development...
  52. ncbi The N-terminal domain of Sxl protein disrupts Sxl autoregulation in females and promotes female-specific splicing of tra in males
    G Deshpande
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 126:2841-53. 1999
    ..determined state and activates female differentiation pathways by directing the female-specific splicing of Sxl and tra pre-mRNAs...
  53. pmc Analysis of the doublesex female protein in Drosophila melanogaster: role on sexual differentiation and behavior and dependence on intersex
    J A Waterbury
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA
    Genetics 152:1653-67. 1999
    ..Finally, we provide evidence that intersex is required for the feminizing activities of Dsx(F) and that it is not regulated by the sex-specific splicing cascade...
  54. pmc Genetic elimination of known pheromones reveals the fundamental chemical bases of mating and isolation in Drosophila
    F Savarit
    Neurobiologie de l Apprentissage et de la Memoire Mécanismes de Communication, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8620, Universite Paris Sud, 91405 Orsay, France
    Proc Natl Acad Sci U S A 96:9015-20. 1999
    Overexpression of the UAS-tra transgene in Drosophila melanogaster females led to the complete elimination of their cuticular pheromones. According to current models of Drosophila behavior, these flies should induce no courtship...
  55. pmc Neutral evolution of the sex-determining gene transformer in Drosophila
    B F McAllister
    Institute for Cell, Animal and Population Biology, University of Edinburgh, United Kingdom
    Genetics 154:1711-20. 2000
    The amino acid sequence of the transformer (tra) gene exhibits an extremely rapid rate of evolution among Drosophila species, although the gene performs a critical step in sex determination...
  56. ncbi Genetic identification of neurons controlling a sexually dimorphic behaviour
    S Gatti
    UMR 8620, Bases Neurales du Mouvement chez la Drosophile, Universite Paris Sud, Orsay, F 91405, France
    Curr Biol 10:667-70. 2000
    ..Nor does it control male courtship behaviour, because feminisation of courtship was not correlated with the feminisation of locomotor activity...
  57. ncbi Alternative pre-mRNA splicing: the logic of combinatorial control
    C W Smith
    Dept of Biochemistry, University of Cambridge, 80 Tennis Court Road, Old Addenbrookes Site, Cambridge, UK CB2 1GA
    Trends Biochem Sci 25:381-8. 2000
    ..Its modulation is achieved through the combinatorial interplay of positive and negative regulatory signals present in the RNA, which are recognized by complexes composed of members of the hnRNP and SR protein families...
  58. ncbi The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to deploy dachshund sex-specifically in the genital imaginal disc
    E L Keisman
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 128:1643-56. 2001
    ..We find that the sex determination pathway acts cell-autonomously to determine whether dac is activated by wg signaling, as in females, or by dpp signaling, as in males...
  59. ncbi Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila
    B S Baker
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 105:13-24. 2001
  60. ncbi Doublesex surprises
    S Vincent
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 106:399-402. 2001
  61. ncbi The sex determination gene doublesex regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc
    E L Keisman
    Department of Biological Sciences, Stanford University, California 94305, USA
    Dev Cell 1:215-25. 2001
    ..Instead, we show that dsx regulates the A/P organizer to control growth of each genital primordium, and then directs each genital primordium to differentiate defined adult structures in both sexes...
  62. pmc A central neural circuit for experience-independent olfactory and courtship behavior in Drosophila melanogaster
    G Heimbeck
    Department of Biology and Program in Neuroscience, University of Fribourg, CH 1700 Fribourg, Switzerland
    Proc Natl Acad Sci U S A 98:15336-41. 2001
    ..Moreover, the involvement of an olfactory pathway in male courtship suggests a role of volatile attractive female pheromones in Drosophila...
  63. ncbi Sex comes in from the cold: the integration of sex and pattern
    Audrey E Christiansen
    Department Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Trends Genet 18:510-6. 2002
    ....
  64. pmc The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior
    Brigitte Dauwalder
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 16:2879-92. 2002
    ..Expression analysis of a subset of these genes suggests that the takeout gene family encodes multiple factors with sex-specific functions...
  65. ncbi Masters change, slaves remain
    Patricia Graham
    Dept Molecular Biology, Princeton University, NJ 08544 1041, USA
    Bioessays 25:1-4. 2003
    ..DmSxl controls the alternative splicing of a downstream gene, transformer (tra), which acts with tra2 to control alternative splicing of doublesex (dsx)...
  66. ncbi Rapid evolution of the sex-determining gene, transformer: structural diversity and rate heterogeneity among sibling species of Drosophila
    Rob J Kulathinal
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 20:441-52. 2003
    While developmentally regulated genes are generally conserved, transformer (tra), a key locus involved in the regulation of sexual differentiation, is highly diverged between species of Drosophila...
  67. ncbi Doublesex gene expression in the central nervous system of Drosophila melanogaster
    Gyunghee Lee
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurogenet 16:229-48. 2002
    ....
  68. pmc Evolution of sexual dimorphism in the olfactory brain of Hawaiian Drosophila
    Yasuhiro Kondoh
    Yamamoto Behaviour Genes Project, ERATO, JST, University of Hawaii, 3050 Maile Way, 408 Gilmore, Honolulu, HI 96822, USA
    Proc Biol Sci 270:1005-13. 2003
    ..The formation of glomeruli of male size is prevented by the ectopic expression of female-type transformer (tra) cDNA in males, indicating that the glomerular sexual dimorphism is under the control of the sex-determination ..
  69. ncbi A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship
    Steven Bray
    Duke University Medical Center, Department of Molecular Genetics and Microbiology, 252 CARL Building, Research Drive, Durham, NC 27710, USA
    Neuron 39:1019-29. 2003
    ....
  70. ncbi Excitatory and inhibitory switches for courtship in the brain of Drosophila melanogaster
    Susan J Broughton
    Department of Biology, New York University, New York, NY 10003, USA
    Curr Biol 14:538-47. 2004
    ..Much less is known of the more expansive, nondimorphic, but nonetheless essential, neural elements subserving male courtship behavior...
  71. pmc The evolution of the Drosophila sex-determination pathway
    Andrew Pomiankowski
    Department of Biology, University College, London NW1 2HE, United Kingdom
    Genetics 166:1761-73. 2004
    ..Our hypothesis is built on the available data from Drosophila and other insect species, and we point out where it is amenable to further experimental and comparative tests...
  72. ncbi The dice of fate: the csd gene and how its allelic composition regulates sexual development in the honey bee, Apis mellifera
    Martin Beye
    Martin Luther Universitat Halle Wittenberg, Biozentrum, Institut fur Zoologie, Weinberg Weg 22, 06120 Halle, Germany
    Bioessays 26:1131-9. 2004
    ..Comparison to hierarchies of dipteran insects suggests that SR-type protein has facilitated the differentiation of sex-determining systems and hierarchies...
  73. ncbi fruitless splicing specifies male courtship behavior in Drosophila
    Ebru Demir
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:785-94. 2005
    ..These females direct their courtship toward other females (or males engineered to produce female pheromones). The splicing of a single neuronal gene thus specifies essentially all aspects of a complex innate behavior...
  74. ncbi Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour
    Devanand S Manoli
    Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Nature 436:395-400. 2005
    ..Together, these data demonstrate that FruM proteins specify the neural substrates of male courtship...
  75. ncbi Genetic variation for expression of the sex determination pathway genes in Drosophila melanogaster
    Aaron M Tarone
    Evolution and Ecology, University of California at Davis, CA 95616, USA
    Genet Res 86:31-40. 2005
    ....
  76. ncbi Fruitless specifies sexually dimorphic neural circuitry in the Drosophila brain
    Ken ichi Kimura
    Laboratory of Biology, Iwamizawa Campus, Hokkaido University of Education, Iwamizawa 068 8642, Japan
    Nature 438:229-33. 2005
    ..Thus, Fru expression can produce a male-specific neural circuit, probably used during heterosexual courtship, by preventing cell death in identifiable neurons...
  77. ncbi Isoform-specific control of male neuronal differentiation and behavior in Drosophila by the fruitless gene
    Jean Christophe Billeter
    IBLS Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, United Kingdom
    Curr Biol 16:1063-76. 2006
    ..These putative transcription factors, containing one of three alternative DNA binding domains, determine the neuronal substrates for sexual behavior in male CNS...
  78. ncbi The control of sexual identity in the Drosophila germline
    Abbie Casper
    Department of Biology, 302 Mudd Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Development 133:2783-91. 2006
    ..Here, we explore how sexual identity is established in the Drosophila germline, how this affects other aspects of germ cell development and what studies in Drosophila can teach us about mammalian germ cells...
  79. pmc Specific subgroups of FruM neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster
    Yick Bun Chan
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:19577-82. 2007
    ....
  80. doi Fruitless and doublesex coordinate to generate male-specific neurons that can initiate courtship
    Ken ichi Kimura
    Laboratory of Biology, Iwamizawa Campus, Hokkaido University of Education, Iwamizawa 068 8642, Japan
    Neuron 59:759-69. 2008
    ..Thus, the coordinated actions of two sex determination genes, dsx and fru, confer the unique ability to initiate male-typical sexual behavior on P1 neurons...
  81. pmc Sexual back talk with evolutionary implications: stimulation of the Drosophila sex-determination gene sex-lethal by its target transformer
    Scott G Siera
    Department of Molecular and Cell Biology, Division of Genetics, Genomics and Development, University of California, Berkeley, California 94720 3204, USA
    Genetics 180:1963-81. 2008
    ..between two key genes of the Drosophila sex-determination gene hierarchy, Sex-lethal (Sxl) and transformer (tra)...
  82. doi Effect of the gene transformer of Anastrepha on the somatic sexual development of Drosophila
    Maria Fernanda Ruiz
    Centro de Investigaciones Biologicas CSIC, Madrid, Spain
    Int J Dev Biol 54:627-33. 2010
    The gene transformer (tra) is the key regulatory memory device for sex determination in tephritid insects...
  83. pmc Sexual dimorphism in the fly brain
    Sebastian Cachero
    Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 20:1589-601. 2010
    ..Subsequently, three discrete anatomical differences in central brain fru+ neurons have been reported, but the global organization of sex differences in wiring is unclear...
  84. pmc Function and evolution of sex determination mechanisms, genes and pathways in insects
    Tanja Gempe
    Department of Genetics, Heinrich Heine University, Duesseldorf, Universitaetsstrasse 1, Duesseldorf, Germany
    Bioessays 33:52-60. 2011
    ..This review summarises recent findings in insects, surveys evidence of how and why sex determination mechanisms can change rapidly and suggests fruitful areas of future research...
  85. pmc Pheromonal and behavioral cues trigger male-to-female aggression in Drosophila
    María de la Paz Fernández
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Biol 8:e1000541. 2010
    ..Therefore, both pheromonal and behavioral cues are used by Drosophila males in recognizing a conspecific as a competitor...
  86. ncbi Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage
    B A Sosnowski
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138
    Cell 58:449-59. 1989
    ..These results are consistent with a model in which female-specific factors block the function of the non-sex-specific 3' splice site...
  87. pmc Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements
    K J Hertel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    RNA 2:969-81. 1996
    ..sequence conservation was demonstrated by showing that the two enhancers are functionally interchangeable in Tra-/Tra2-dependent in vitro splicing...
  88. pmc Enhancer-dependent 5'-splice site control of fruitless pre-mRNA splicing
    Bianca J Lam
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, California 92697 4025, USA
    J Biol Chem 278:22740-7. 2003
    ..Alternative splicing of fru is regulated by TRA and TRA2 and depends on an exonic splicing enhancer (fruRE) consisting of three 13-nucleotide repeat elements, ..
  89. ncbi Is sex determination in germ line and soma controlled by separate genetic mechanisms?
    J L Marsh
    Nature 272:249-51. 1978
  90. ncbi Fly sex drive traced to fru gene
    W Roush
    Science 274:1836. 1996
  91. pmc Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf(+) gene dose effects
    T W Cline
    Department of Molecular Biology, University of California, Berkeley, 401 Barker Hall, Berkeley, CA 94720 3204, USA
    Proc Natl Acad Sci U S A 96:14451-8. 1999
    ..Mammalian U1A protein, like Snf, has a snRNP-independent function...
  92. ncbi What determines the rate of sequence evolution?
    J F Brookfield
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, UK
    Curr Biol 10:R410-R0411. 2000
    ..However, two recent studies have shown that rapid evolution of amino-acid sequence can also be congruent with neutrality...
  93. ncbi Cell-autonomous and somatic signals control sex-specific gene expression in XY germ cells of Drosophila
    B Janzer
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mech Dev 100:3-13. 2001
    ..We thus report for the first time the existence of downstream targets of the gene Sxl in the germline...
  94. ncbi Temperature affects the ontogeny of sexually dimorphic cuticular hydrocarbons in Drosophila melanogaster
    Fabrice Savarit
    LEEC, CNRS FRE 2413, Universite Paris 13, 93430 Villetaneuse, France
    J Exp Biol 205:3241-9. 2002
    ..This study describes the time course of the events involved in the production of male- and female-predominant CHs. We also found that 'immature' CHs, sexually monomorphic CHs on younger flies, were not affected by these treatments...
  95. ncbi Sex determination in flies, fruitflies and butterflies
    G Saccone
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita degli Studi di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
    Genetica 116:15-23. 2002
    ..Indeed, the molecularly characterized genes of the Drosophila sex determination hierarchy X:A > Sxl > tra > dsx have been fruitful starting points in the cloning of homologous genes from other insect species...
  96. ncbi Male-specific expression of the fruitless protein is not common to all Drosophila species
    Daisuke Yamamoto
    Laboratory of Genetics, Graduate School of Human Sciences, Waseda University, Higashi Fushimi, Nishi Tokyo, Tokyo 202 0021, Japan
    Genetica 120:267-72. 2004
    ..This male-specific translation of Fru was also observed in D. simulans, D. yakuba, D. pseudoobscura and D. virilis; however, in D. suzukii, the Fru protein expression was detected even in the female CNS...
  97. ncbi Sex determination and differentiation in invertebrates: Drosophila and Caenorhabditis elegans
    M McKeown
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Curr Opin Cell Biol 4:948-54. 1992
    ..We are now gaining an understanding of the molecular mechanisms governing the largely post-transcriptional regulation of the intermediate steps in these cascades...
  98. ncbi Mechanisms of alternative pre-mRNA splicing
    T Maniatis
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138
    Science 251:33-4. 1991
  99. ncbi Molecular genetics of transformer, a genetic switch controlling sexual differentiation in Drosophila
    J M Belote
    Department of Biology, Syracuse University, New York 13244
    Dev Genet 10:143-54. 1989
    ..The female-specific expression of the tra gene, previously inferred from genetic observations, is based on sex-specific alternative splicing of tra pre-mRNA ..
  100. ncbi Overlapping genes of Drosophila melanogaster: organization of the z600-gonadal-Eip28/29 gene cluster
    R A Schulz
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 3:232-42. 1989
    ..An analysis of germ-line transformants reveals that gdl can be expressed properly outside the overlapping gene environment because a 1.8-kb DNA region contains all the sequences necessary for gdl sex-specific expression...
  101. ncbi Control of sexual differentiation in Drosophila melanogaster
    J M Belote
    Cold Spring Harb Symp Quant Biol 50:605-14. 1985

Research Grants10

  1. AGE-RELATED NON-DISJUNCTION IN OOCYTES
    HELEN SALZ; Fiscal Year: 2004
    ..abstract_text> ..
  2. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
    ..of chronobiology in this model system may provide insights into the nature of certain rhythm-related disorders of humans, some of which are associated with genetic variations of Drosophila clock gene orthologs [unreadable] [unreadable]..
  3. Molecular genetics of egg activation and pronuclear function in Drosophila
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2010
    ..Thus, we exploit the powerful genetics of Drosophila to elucidate efficiently the molecules and gene pathways needed to start development in humans. ..
  4. Regulation of Sex-lethal pre-mRNA splicing during Drosophila development
    HELEN KAREN SALZ; Fiscal Year: 2010
    ..Due to the remarkable conservation of the splicing machinery from humans to flies, the paradigms we develop using the very tractable Drosophila system are relevant to human biology. ..
  5. THERMODYNAMICS AND STRUCTURE OF POLYMERIZING ACTIN
    SANDRA GREER; Fiscal Year: 2001
    ..abstract_text> ..
  6. GENETIC ANALYSIS OF MORPHOGENESIS IN A NEMATODE
    Scott Emmons; Fiscal Year: 2005
    ..This research will contribute to understanding a fundamental aspect of animal development, and thus help towards progress in overcoming diseases that arise as a result of developmental abnormalities. ..
  7. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
    ..melanogaster ..
  8. The Mechanisms and Regulatory Networks of Alternative Splicing in Drosophila
    BRENTON GRAVELEY; Fiscal Year: 2009
    ....
  9. Connectivity in the Nematode Nervous System
    Scott Emmons; Fiscal Year: 2002
    ..The preanal ganglion circuitry provides a unique opportunity to explore the development and function of a defined set of synapses during postembryonic life in a system which is not essential for survival in this hermaphroditic species. ..
  10. NEURON DIFFERENTIATION IN C ELEGANS
    Scott Emmons; Fiscal Year: 2002
    ..3) screen for mutants (including ts alleles) in which TH::GFP expression is lost and characterize the corresponding genes molecularly. (4) identify genes involved in the axon connectivity of DA neurons. ..