trp

Summary

Gene Symbol: trp
Description: transient receptor potential
Alias: 559, CG7875, DmTRP, Dmel\CG7875, TRP, Trp, dTRP, dTrp, gene B, idl-B, CG7875 gene product from transcript CG7875-RA, CG7875-PA, CG7875-PB, Cosens-Manning mutant, INAD localization-B, transient photreceptor potential, transient receptor potential protein, trp-PA, trp-PB
Species: fruit fly

Top Publications

  1. pmc The biology of vision of Drosophila
    C S Zuker
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093 0649, USA
    Proc Natl Acad Sci U S A 93:571-6. 1996
  2. ncbi Calcium homeostasis in photoreceptor cells of Drosophila mutants inaC and trp studied with the pupil mechanism
    C A Hofstee
    Department of Biophysics, University of Groningen, The Netherlands
    Vis Neurosci 13:257-63. 1996
  3. ncbi Calcium signalling: setting store by calcium channels
    R C Hardie
    Cambridge University, Department of Anatomy, UK
    Curr Biol 6:1371-3. 1996
  4. ncbi Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies
    F M Adamski
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 273:17713-9. 1998
  5. ncbi Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
    S Chyb
    Cambridge University Department of Anatomy, UK
    Nature 397:255-9. 1999
  6. ncbi Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD
    P D Wes
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 2:447-53. 1999
  7. doi The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin
    Claudia Oberegelsbacher
    Department of Biosensorics, Institute of Physiology, University of Hohenheim, 70599 Stuttgart, Germany
    Eur J Cell Biol 90:620-30. 2011
  8. ncbi The cellular and molecular basis of store-operated calcium entry
    Kartik Venkatachalam
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Cell Biol 4:E263-72. 2002
  9. pmc Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade
    Nina E Meyer
    Department of Biosensorics, Institute of Physiology, University of Hohenheim, 70599 Stuttgart, Germany
    J Cell Sci 119:2592-603. 2006
  10. pmc Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors
    Akiko K Satoh
    Department of Biological Sciences, Graduate School of Science, Nagoya University, Nagoya 466 8601, Japan
    Neuron 67:997-1008. 2010

Research Grants

  1. MEKK2 KO DEFINES HEMATOPOIETIC CELL SIGNAL FUNCTION
    Timothy Garrington; Fiscal Year: 2004
  2. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011
  3. Conference Proposal: Calcium and Cell Function
    Craig Montell; Fiscal Year: 2004
  4. APTAMERS TO ANALYZE REGULATORY NETWORKS IN DROSOPHILA
    RUSSELL FINLEY; Fiscal Year: 2004
  5. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
  6. A Drosophila geneome-wide protein interaction map
    RUSSELL FINLEY; Fiscal Year: 2009
  7. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
  8. Temperature Sensation and Its Behavioral Consequences
    MIRIAM GOODMAN; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. pmc The biology of vision of Drosophila
    C S Zuker
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093 0649, USA
    Proc Natl Acad Sci U S A 93:571-6. 1996
    ..In this manuscript I review some of our recent findings and the strategies used to dissect this process...
  2. ncbi Calcium homeostasis in photoreceptor cells of Drosophila mutants inaC and trp studied with the pupil mechanism
    C A Hofstee
    Department of Biophysics, University of Groningen, The Netherlands
    Vis Neurosci 13:257-63. 1996
    ..by in vivo reflection microspectrophotometry in wild type (WT) Drosophila and in the photoreceptor mutants inaC and trp. The pupillary response of a dark-adapted WT eye to a step in light is a monophasic reflectance increase reaching a ..
  3. ncbi Calcium signalling: setting store by calcium channels
    R C Hardie
    Cambridge University, Department of Anatomy, UK
    Curr Biol 6:1371-3. 1996
    ..Recent work, stemming from genetic studies of phototransduction in Drosophila, has identified a set of homologous channel proteins that appear to mediate capacitative Ca2+ entry in species from worms and files to humans...
  4. ncbi Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies
    F M Adamski
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 273:17713-9. 1998
    ..eye-PKC, NORPA (phospholipase Cbeta), and transient-receptor-potential (TRP) (calcium channel) are integral components of a signal transduction complex organized by INAD, a protein containing ..
  5. ncbi Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
    S Chyb
    Cambridge University Department of Anatomy, UK
    Nature 397:255-9. 1999
    ..that both of these fatty acids reversibly activate native light-sensitive channels (transient receptor potential (TRP) and TRP-like (TRPL)) in Drosophila photoreceptors as well as recombinant TRPL channels expressed in Drosophila S2 ..
  6. ncbi Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD
    P D Wes
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 2:447-53. 1999
    ..Disruption of the NINAC/INAD interaction delayed termination of the photoreceptor response. Thus one role of this signaling complex is in rapid deactivation of the photoresponse...
  7. doi The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin
    Claudia Oberegelsbacher
    Department of Biosensorics, Institute of Physiology, University of Hohenheim, 70599 Stuttgart, Germany
    Eur J Cell Biol 90:620-30. 2011
    ..is embedded in the rhabdomeres of photoreceptor cells and culminates in the opening of the two ion channels, TRP and TRPL...
  8. ncbi The cellular and molecular basis of store-operated calcium entry
    Kartik Venkatachalam
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Cell Biol 4:E263-72. 2002
    ..Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals...
  9. pmc Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade
    Nina E Meyer
    Department of Biosensorics, Institute of Physiology, University of Hohenheim, 70599 Stuttgart, Germany
    J Cell Sci 119:2592-603. 2006
    Signal-mediated translocation of transient receptor potential (TRP) channels is a novel mechanism to fine tune a variety of signaling pathways including neuronal path finding and Drosophila photoreception...
  10. pmc Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors
    Akiko K Satoh
    Department of Biological Sciences, Graduate School of Science, Nagoya University, Nagoya 466 8601, Japan
    Neuron 67:997-1008. 2010
    ..of key phototransduction proteins, including phospholipase C (PLC), Gq, and the light-sensitive Ca2+-permeable TRP channels, slows translocation by 10- to 100-fold...
  11. ncbi INDO-1 measurements of absolute resting and light-induced Ca2+ concentration in Drosophila photoreceptors
    R C Hardie
    Cambridge University, Department of Anatomy, United Kingdom
    J Neurosci 16:2924-33. 1996
    ..7 nM/pC. In the transient receptor potential (trp) mutant, which lacks a putative light-sensitive channel subunit, the slope was only 1.1 nM/pC, indicating a 2...
  12. ncbi Protein modules as organizers of membrane structure
    A S Fanning
    Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, PO Box 208019, New Haven, CT 06520 8019, USA
    Curr Opin Cell Biol 11:432-9. 1999
    ..The organization of these proteins into discreet structures has functional consequences for downstream signaling...
  13. ncbi TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL
    X Z Xu
    Department of Biological Chemistry and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 26:647-57. 2000
    b>TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete...
  14. ncbi Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels
    H T Ma
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 276:18888-96. 2001
    ..Although SOCs have not been molecularly identified, transient receptor potential (TRP) channels share a number of operational parameters with SOCs...
  15. pmc Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels
    J Tang
    Neurobiotechnology Center, Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 276:21303-10. 2001
    Homologues of Drosophila Trp (transient receptor potential) form plasma membrane channels that mediate Ca(2+) entry following the activation of phospholipase C by cell surface receptors...
  16. ncbi In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1)
    Roger C Hardie
    Department of Anatomy, Cambridge University, Downing St, Cambridge CB2 3DY, United Kingdom
    J Biol Chem 279:47773-82. 2004
    ..recordings were made from mutants lacking both classes of light-sensitive transient receptor potential channels (TRP and TRPL)...
  17. ncbi lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction
    Isaac Garcia-Murillas
    Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Neuron 49:533-46. 2006
    ..PI(4,5)P2 by phospholipase Cbeta (PLCbeta) to generate a second messenger that opens the light-activated channels TRP and TRPL...
  18. ncbi Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene
    A M Phillips
    Department of Genetics, University of Melbourne, Parkville, Victoria, Australia
    Neuron 8:631-42. 1992
    ..acid sequence and tissue-specific expression are observed between this gene and the transient receptor potential (trp) gene. We propose the name transient receptor potential-like (trpl) to describe this newly isolated gene...
  19. ncbi The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors
    R C Hardie
    Department of Zoology, Cambridge University, England
    Neuron 8:643-51. 1992
    ..In the transient receptor potential (trp) mutant, one of the most intensively studied transduction mutants of Drosophila, the light response quickly ..
  20. ncbi Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction
    C Montell
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Neuron 2:1313-23. 1989
    ..the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequent to the production of IP3...
  21. pmc Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors
    A Peretz
    Department of Physiology, Hadassah Medical School, Hebrew University, Jerusalem, Israel
    J Gen Physiol 104:1057-77. 1994
    ..delta Ca2+]o in Drosophila retina using Ca(2+)-selective microelectrodes in both the transient receptor potential (trp) mutant, in which the calcium permeability of the light-sensitive channels is greatly diminished and in the ..
  22. ncbi TRP, a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors
    J A Pollock
    Center for Light Microscopic Imaging and Biotechnology, Mellon University, Pittsburgh, Pennsylvania 15213 3890, USA
    J Neurosci 15:3747-60. 1995
    The Drosophila transient receptor potential (trp) gene product (TRP) shows some structural similarity to vertebrate voltage-gated Ca2+ channels...
  23. ncbi The light response of Drosophila photoreceptors is accompanied by an increase in cellular calcium: effects of specific mutations
    A Peretz
    Department of Physiology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Neuron 12:1257-67. 1994
    ..In Calcium Green-5N-loaded trp mutants, which lack a large fraction of the Ca2+ permeability underlying the light-evoked inward current, the Ca2+ ..
  24. ncbi Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp
    R C Hardie
    Department of Anatomy, University of Cambridge, UK
    Cell Calcium 18:256-74. 1995
    ..The light-activated conductance in Drosophila is normally highly permeable to Ca2+, but in null mutants of the trp gene Ca2+ permeability is greatly reduced...
  25. ncbi Regulation of the TRP Ca2+ channel by INAD in Drosophila photoreceptors
    B H Shieh
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6600, USA
    Neuron 16:991-8. 1996
    ..We report that anti-INAD antibodies coimmunoprecipitate TRP, identified by its electrophoretic mobility, cross reactivity with anti-TRP antibody, and absence in a null allele ..
  26. ncbi The Drosophila light-activated conductance is composed of the two channels TRP and TRPL
    B A Niemeyer
    Howard Hughes Medical Institute, Department of Biology, Department of Neurosciences, University of California at San Diego, La Jolla, California 92093 0649, USA
    Cell 85:651-9. 1996
    ..The Drosophila light-activated conductance is constituted in part by the transient receptor potential (trp) ion channel, yet trp mutants still display a robust response demonstrating the presence of additional channels...
  27. pmc The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD
    A Huber
    Zoological Institute I, University of Karlsruhe, Germany
    EMBO J 15:7036-45. 1996
    The transient receptor potential protein (Trp) is a putative capacitative Ca2+ entry channel present in fly photoreceptors, which use the inositol 1,4,5-trisphosphate (InsP3) signaling pathway for phototransduction...
  28. ncbi Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex
    J Chevesich
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 18:95-105. 1997
    In Drosophila, the store-operated Ca2+ channel, TRP, is required in photoreceptor cells for a sustained response to light...
  29. ncbi Coassembly of TRP and TRPL produces a distinct store-operated conductance
    X Z Xu
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 89:1155-64. 1997
    The Drosophila retinal-specific protein, TRP (transient receptor potential), is the founding member of a family of store-operated channels (SOCs) conserved from C. elegans to humans...
  30. ncbi A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
    S Tsunoda
    Howard Hughes Medical Institute, and Department of Biology, University of California at San Diego, La Jolla 92093 0649, USA
    Nature 388:243-9. 1997
    ..A picture emerges of a highly organized unit of signalling, a 'transduclisome', with PDZ domains functioning as key elements in the organization of transduction complexes in vivo...
  31. pmc The phosphatidylinositol transfer protein domain of Drosophila retinal degeneration B protein is essential for photoreceptor cell survival and recovery from light stimulation
    S C Milligan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Cell Biol 139:351-63. 1997
    ..This in vivo analysis of PITP function in a metazoan system provides further insights into the links between PITP dysfunction and an inherited disease in a higher eukaryote...
  32. pmc Association of INAD with NORPA is essential for controlled activation and deactivation of Drosophila phototransduction in vivo
    B H Shieh
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6600, USA
    Proc Natl Acad Sci U S A 94:12682-7. 1997
    ..phospholipase C-mediated process that leads to depolarization via activation of the transient receptor potential (TRP) calcium channel...
  33. ncbi In vivo analysis of the drosophila light-sensitive channels, TRP and TRPL
    H Reuss
    Department of Anatomy, Cambridge University, United Kingdom
    Neuron 19:1249-59. 1997
    ..conductance with that in mutants lacking one or the other of the putative light-sensitive channel subunits, TRP and TRPL...
  34. ncbi Olfactory adaptation depends on the Trp Ca2+ channel in Drosophila
    K F Störtkuhl
    Department of Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    J Neurosci 19:4839-46. 1999
    ..Mutants of the transient receptor potential (Trp) Ca2+ channel were normal in olfactory response, but defective in olfactory adaptation, when measured either ..
  35. ncbi Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila
    J Yoon
    Institute of Genetic Engineering and Natural Sciences, Department of Genetic Engineering, Kyunghee University, Yongin City, Kyungki do, 449 701 Korea
    J Neurosci 20:649-59. 2000
    The Drosophila trp gene encodes a light-activated Ca(2+) channel subunit, which is a prototypical member of a novel class of channel proteins...
  36. pmc Single photon responses in Drosophila photoreceptors and their regulation by Ca2+
    S R Henderson
    Cambridge University, Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK
    J Physiol 524:179-94. 2000
    ..Quantum bumps in trp mutants lacking the major class of light-sensitive channel were reduced in size (mean 3...
  37. ncbi Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors
    M Liu
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 275:12194-9. 2000
    In the Drosophila visual cascade, the transient receptor potential (TRP) calcium channel, phospholipase Cbeta (no-receptor-potential A), and an eye-specific isoform of protein kinase C (eye-PKC) comprise a multimolecular signaling ..
  38. ncbi Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA
    P Raghu
    Department of Anatomy, Cambridge University, United Kingdom
    Neuron 26:169-79. 2000
    ..Whole-cell recordings revealed that light-sensitive Ca2+ channels encoded by the trp gene were constitutively active in rdgA photoreceptors...
  39. ncbi Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo
    K Agam
    Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurosci 20:5748-55. 2000
    Drosophila transient receptor potential (TRP) is a prototypical member of a novel family of channel proteins underlying phosphoinositide-mediated Ca(2+) entry...
  40. ncbi Phenotypes of trpl mutants and interactions between the transient receptor potential (TRP) and TRP-like channels in Drosophila
    H T Leung
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 1392, USA
    J Neurosci 20:6797-803. 2000
    The trp and trpl genes are thought to encode two classes of light-activated ion channels in Drosophila. A previous report indicated that a null trpl mutant does not display any mutant phenotype...
  41. ncbi Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors
    S Tsunoda
    Howard Hughes Medical Institute and Departments of Biology and Neurosciences, University of California at San Diego, La Jolla, California 92093 0649, USA
    J Neurosci 21:150-8. 2001
    ..phototransduction cascade into a macromolecular signaling complex containing the effector PLC, the light-activated TRP channels, and a regulatory PKC...
  42. ncbi Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors
    R C Hardie
    Department of Anatomy, Cambridge, United Kingdom
    Neuron 30:149-59. 2001
    The trp (transient receptor potential) gene encodes a Ca2+ channel responsible for the major component of the phospholipase C (PLC) mediated light response in Drosophila...
  43. ncbi Visual transduction in Drosophila
    R C Hardie
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Nature 413:186-93. 2001
    ..Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance...
  44. ncbi Phototransduction in Drosophila melanogaster
    R C Hardie
    Cambridge University, Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK
    J Exp Biol 204:3403-9. 2001
    ..glycerol (DAG), leading to activation of two classes of Ca(2+)-permeable light-sensitive channel, encoded by the trp and trpl genes...
  45. ncbi Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current
    Monika Bähner
    Zoological Institute, Department of Cell and Neurobiology, University of Karlsruhe, 76128 Karlsruhe, Germany
    Neuron 34:83-93. 2002
    ..in the opening of two classes of cation channels, composed of the channel subunits transient receptor potential (TRP), TRP-like (TRPL), and TRPgamma...
  46. ncbi Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin
    Seung Jae Lee
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 39:121-32. 2003
    ..Since phospholipase C activity is required for activation of Drosophila phototransduction, these data point to a dual role of PIs in phototransduction...
  47. ncbi Light-dependent subcellular translocation of Gqalpha in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC
    Michelle A Cronin
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 117:4797-806. 2004
    ....
  48. ncbi TRP channels at a glance
    Raghu Padinjat
    Signalling Programme, Babraham Institute, Cambridge, CB2 4AT, UK
    J Cell Sci 117:5707-9. 2004
  49. ncbi Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX
    Tao Wang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 45:367-78. 2005
    ..CalX had reciprocal effects and greatly suppressed the retinal degeneration caused by constitutive activity of the TRP channel...
  50. pmc Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium
    Matthew R MacPherson
    IBLS Division of Molecular Genetics, University of Glasgow, UK
    Genetics 169:1541-52. 2005
    ..We demonstrate the first epithelial role, in vivo, for members of the TRP family of calcium channels. RT-PCR revealed expression of trp, trpl, and trpgamma in tubules...
  51. ncbi Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors
    Akiko K Satoh
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Development 132:1487-97. 2005
    ..Furthermore, Rab11 is required for transport of TRP, another rhabdomeric protein, and for development of specialized membrane structures within Garland cells...
  52. pmc Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid
    Mary M LaLonde
    Program in Molecular and Cellular Biology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794, USA
    J Cell Biol 169:471-9. 2005
    ..Altogether, these findings suggest that Pld facilitates phototransduction by maintaining adequate levels of PIP2 and by protecting the visual system from metarhodopsin-induced, low light degeneration...
  53. ncbi Mechanisms of light adaptation in Drosophila photoreceptors
    Yuchun Gu
    Department of Anatomy, Cambridge University, Downing Street, Cambridge CB2 3DY, United Kingdom
    Curr Biol 15:1228-34. 2005
    ..is mediated by a phospholipase C (PLC) cascade culminating in activation of transient receptor potential (TRP) channels...
  54. pmc Activity-independent prespecification of synaptic partners in the visual map of Drosophila
    P Robin Hiesinger
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Biol 16:1835-43. 2006
    ..analysis of photoreceptor synapses in mutants affecting the generation of electrical potentials (norpA, trp;trpl), neurotransmitter release (hdc, syt), vesicle endocytosis (synj), the trafficking of specific guidance ..
  55. pmc Light-induced recruitment of INAD-signaling complexes to detergent-resistant lipid rafts in Drosophila photoreceptors
    Parthena D Sanxaridis
    Department of Biology, Boston University, Boston, MA 02215, USA
    Mol Cell Neurosci 36:36-46. 2007
    ..Mutations affecting INAD and TRP showed that PDZ4 and PDZ5 domains of INAD, as well as the INAD-TRP interaction, are required for translocation of ..
  56. pmc Anchoring TRP to the INAD macromolecular complex requires the last 14 residues in its carboxyl terminus
    Li Peng
    Department of Pharmacology, Center for Molecular Neuroscience, and Vanderbilt Vision Research Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Neurochem 104:1526-35. 2008
    Drosophila transient-receptor-potential (TRP) is a Ca2+ channel responsible for the light-dependent depolarization of photoreceptors. TRP is anchored to a macromolecular complex by tethering to inactivation-no-afterpotential D (INAD)...
  57. doi Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade
    Young Kwon
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, 855 North Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 11:871-3. 2008
    ..We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range...
  58. pmc Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster
    Mark Rosenzweig
    National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, MA 02458, USA
    Proc Natl Acad Sci U S A 105:14668-73. 2008
    ..At the molecular level, members of the transient receptor potential (TRP) family of cation channels contribute to thermosensory behaviors in animals from flies to humans...
  59. pmc Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels
    Moshe Parnas
    Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    Cell Calcium 45:300-9. 2009
    Transient receptor potential (TRP) channels are essential components of biological sensors that detect changes in the environment in response to a myriad of stimuli...
  60. doi Unitary recordings of TRP and TRPL channels from isolated Drosophila retinal photoreceptor rhabdomeres: activation by light and lipids
    Ricardo Delgado
    Dept of Biology, Faculty of Sciences, University of Chile, P O Box 653, Santiago, Chile
    J Neurophysiol 101:2372-9. 2009
    Transient receptor potential (TRP) channels play key roles in sensory transduction...
  61. doi Activation of TRP channels by protons and phosphoinositide depletion in Drosophila photoreceptors
    Jiehong Huang
    Department of Physiology, Development, and Neuroscience, Cambridge University, Cambridge CB2 3DY, UK
    Curr Biol 20:189-97. 2010
    ..phospholipase C (PLC), but how PLC activation leads to the opening of the light-sensitive TRPC channels (TRP and TRPL) remains unresolved...
  62. pmc Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal
    Young Kwon
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 20:1672-8. 2010
    ....
  63. pmc Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall
    Yang Xiang
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California San Francisco, San Francisco, California 94158, USA
    Nature 468:921-6. 2010
    ..These novel photoreceptors use phototransduction machinery distinct from other photoreceptors in Drosophila and enable larvae to sense light exposure over their entire bodies and move out of danger...
  64. doi The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye
    Wei Liu
    Division of Life Science, Molecular Neuroscience Center, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Cell 145:1088-101. 2011
    ..of PIP(2), disrupts the interaction between PDZ4 and PDZ5, leading to PDZ5 oxidation and dissociation from the TRP Ca(2+) channel, a key component of fly visual signaling...
  65. pmc Translocation of the Drosophila transient receptor potential-like (TRPL) channel requires both the N- and C-terminal regions together with sustained Ca2+ entry
    David Richter
    Department of Biosensorics, Institute of Physiology, University of Hohenheim, 70599 Stuttgart, Germany
    J Biol Chem 286:34234-43. 2011
    In Drosophila photoreceptors the transient receptor potential-like (TRPL), but not the TRP channels undergo light-dependent translocation between the rhabdomere and cell body...
  66. doi A subset of dopamine neurons signals reward for odour memory in Drosophila
    Chang Liu
    Max Planck Institut fur Neurobiologie, Martinsried 82152, Germany
    Nature 488:512-6. 2012
    ..Dopamine in insects is known to mediate aversive reinforcement signals. Our results highlight the cellular specificity underlying the various roles of dopamine and the importance of spatially segregated local circuits within the MBs...
  67. pmc Depletion of PtdIns(4,5)P₂ underlies retinal degeneration in Drosophila trp mutants
    Sukanya Sengupta
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Cell Sci 126:1247-59. 2013
    The prototypical transient receptor potential (TRP) channel is the major light-sensitive, and Ca(2+)-permeable channel in the microvillar photoreceptors of Drosophila...
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    C Montell
    Science 230:1040-3. 1985
    ..Mutations such as transient receptor potential (trp) affect intermediate steps in phototransduction...
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    R C Hardie
    Department of Zoology, Cambridge University, UK
    Nature 363:634-7. 1993
    ..Furthermore, we show that in the absence of PKC individual bumps fail to terminate normally, an effect that can account for the pleiotropic manifestations of the inaC phenotype...
  70. ncbi Calmodulin regulation of Drosophila light-activated channels and receptor function mediates termination of the light response in vivo
    K Scott
    Howard Hughes Medical Institute, Department of Biology, University of California at San Diego, La Jolla 92093 0649, USA
    Cell 91:375-83. 1997
    ..Contrary to current models of excitation and TRP channel function, we demonstrate that the transient phenotype of trp mutants can be explained by CAM regulation of ..
  71. pmc TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells
    H S Li
    Department of Biological Chemistry and Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 150:1411-22. 2000
    ..At least seven proteins bind INAD, including the transient receptor potential (TRP) channel, which depends on INAD for localization to the phototransducing organelle, the rhabdomere...
  72. ncbi A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channels
    Paula R Towers
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
    Bioessays 24:1066-73. 2002
    ..In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines...
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    Mickey Kosloff
    Department of Biological Chemistry and the Kuhne Minerva Center for Studies of Visual Transduction, Institute of Life Sciences, The Hebrew University, Givat Ram, Jerusalem, 91904, Israel
    EMBO J 22:459-68. 2003
    ....
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    Michelle A Cronin
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 119:2935-44. 2006
    Transient receptor potential (TRP) channels across species are expressed in sensory receptor cells, and often localized to specialized subcellular sites...
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    C Montell
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Neurobiol 8:389-97. 1998
    ..the Drosophila eye, photoactivation of rhodopsin leads to the opening of the light-sensitive cation influx channels TRP and TRPL...
  77. ncbi Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway
    Seung Jae Lee
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA
    Curr Biol 14:2076-85. 2004
    ..It has been presumed that the visual impairment resulting from long-term, continuous exposure to ambient light is a secondary consequence of the effects of light on retinal morphology, but this has not been addressed...
  78. ncbi Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant
    Plamen Georgiev
    The Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
    J Cell Sci 118:1373-84. 2005
    The TRP family of ion channels mediates a wide range of calcium-influx phenomena in eukaryotic cells...
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    B Minke
    J Gen Physiol 79:361-85. 1982
    In the transient receptor potential (trp) mutant of Drosophila, the receptor potential appears almost normal in response to a flash but quickly decays to baseline during prolonged illumination...
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    R C Hardie
    Department of Zoology, Cambridge University, United Kingdom
    J Gen Physiol 103:409-27. 1994
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    D L Bennett
    Laboratory of Molecular Signalling, Department of Zoology, Cambridge, UK
    Curr Biol 5:1225-8. 1995
    ..Capacitative Ca(2+) entry produces the very rapid light response in Drosophila photoreceptors; studies using this amenable system may help unravel the machinery and mechanisms that underlie this Ca(2+)-entry pathway...
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    R C Hardie
    Department of Anatomy, Cambridge University, UK
    Cell Calcium 21:431-40. 1997
    Drosophila photoreceptors express two putative cation channels encoded by the transient receptor potential (trp) and trp-like (trpl) genes, which represent prototypical members of a novel family of phosphoinositide-regulated calcium ..
  83. ncbi TRP, TRPL and trouble in photoreceptor cells
    K Scott
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093 0649, USA
    Curr Opin Neurobiol 8:383-8. 1998
    Calcium influx through the TRP and TRPL light-activated channels triggers a complex regulatory hierarchy resulting in positive and negative feedback regulation of the phototransduction cascade...
  84. ncbi The roles of PDZ-containing proteins in PLC-beta-mediated signaling
    P G Suh
    Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790 784, South Korea
    Biochem Biophys Res Commun 288:1-7. 2001
    ..NORPA, a Drosophila PLC-beta, is known to be a component of a signaling complex that includes TRP and rhodopsin through interaction with INAD, a PDZ-containing protein...
  85. ncbi The TRP family of cation channels: probing and advancing the concepts on receptor-activated calcium entry
    Christof Zitt
    Institut fur Physiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, D 52074, Aachen, Germany
    Prog Neurobiol 66:243-64. 2002
    ..advanced by the discovery of mammalian homologs of the Drosophila cation channel transient receptor potential (TRP)...
  86. pmc Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity
    Junhai Han
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO J 26:4966-73. 2007
    ..Our work has identified an arrestin-independent endocytic pathway of G protein-coupled receptor in the fly. This pathway may also function in mammals and mediate an early feedback regulation of receptor signaling...
  87. doi Light-dependent modulation of Shab channels via phosphoinositide depletion in Drosophila photoreceptors
    Yani Krause
    University of Oulu, Department of Physical Sciences, Division of Biophysics, 90014 Oulun yliopisto, Finland
    Neuron 59:596-607. 2008
    ..The results indicate a functionally implemented mechanism of Kv channel modulation by PIP(2) in photoreceptors, which enables light-dependent regulation of signal processing by direct coupling to the phototransduction cascade...
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    Lina Ni
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci 28:13478-87. 2008
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    R Ranganathan
    Dept of Biology, University of California, San Diego, La Jolla 92093
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    Fruitflies carrying the autosomal recessive mutation transient receptor potential (trp) are blind in bright light because the receptor potential of such a mutant decays almost completely during an intense stimulus...
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    C C Petersen
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, U K
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    ..It has been suggested that the protein encoded by the transient receptor potential (trp) gene expressed in Drosophila photoreceptors may be homologous with capacitative calcium entry channels...
  95. ncbi Drosophila in vision research. The Friedenwald Lecture
    W L Pak
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Invest Ophthalmol Vis Sci 36:2340-57. 1995
    ..Study of trp mutants is providing insights into this process...
  96. ncbi Missing link in ion channels
    M Strong
    Nature 362:26. 1993
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    R M Kliman
    Department of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855 1059
    Genetics 137:1049-56. 1994
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    R C Hardie
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  99. ncbi The COOH-terminal domain of Drosophila TRP channels confers thapsigargin sensitivity
    W G Sinkins
    Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Biol Chem 271:2955-60. 1996
    Previous studies have shown that the Drosophila cation channels designated Trp and Trpl can be functionally expressed in Sf9 insect cells using baculovirus expression vectors...
  100. ncbi TRP is cracked but is CRAC TRP?
    D E Clapham
    Mayo Foundation, Rochester, Minnesota 55905, USA
    Neuron 16:1069-72. 1996
  101. ncbi Excitation of Drosophila photoreceptors by BAPTA and ionomycin: evidence for capacitative Ca2+ entry?
    R C Hardie
    Department of Anatomy, University of Cambridge, UK
    Cell Calcium 20:315-27. 1996
    ..the light-activated conductance and were similarly affected by a null mutation of the transient receptor potential (trp) gene which is believed to encode a subunit of the light-sensitive channels...

Research Grants8

  1. MEKK2 KO DEFINES HEMATOPOIETIC CELL SIGNAL FUNCTION
    Timothy Garrington; Fiscal Year: 2004
    ..Gary Johnson's lab is an ideal environment in which to learn these skills. ..
  2. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011
    ..The Health-Relatedness of this proposal is that such chemical agents may act to reduce infectious disease transmission by vector insects in the future. ..
  3. Conference Proposal: Calcium and Cell Function
    Craig Montell; Fiscal Year: 2004
    ..The topics to be covered at the meeting are of fundamental importance and are relevant to understanding the bases of a diseases such as neurodegeneration, communicative disorders, aging, cancer, kidney and cardiovascular disease. ..
  4. APTAMERS TO ANALYZE REGULATORY NETWORKS IN DROSOPHILA
    RUSSELL FINLEY; Fiscal Year: 2004
    ..4) To use peptide aptomers to analyze the function of this core group of proteins. ..
  5. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
    ..The health relatedness of these studies is that an understanding of circuits underlying sensory perception is relevant for brain disorders with a neurological or psychiatric basis. ..
  6. A Drosophila geneome-wide protein interaction map
    RUSSELL FINLEY; Fiscal Year: 2009
    ..Combined, the data from this project will provide a foundation for understanding the functions of conserved protein networks and for modeling complex biological processes and diseases. ..
  7. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
    ..The health relatedness of these studies is that cellular and molecular factors that regulate axonal pathfinding may have direct application to neurological and psychiatric disorders with a developmental basis. ..
  8. Temperature Sensation and Its Behavioral Consequences
    MIRIAM GOODMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..