Genomes and Genes
Gene Symbol: zip
Alias: CG15792, DROMHC, Dm nmII, Dmel\CG15792, DmnmII, Dronm-MII, E(br), MHC, Mhc-c, Mhc-c, Myo, Myo II, Myo-II, Myo-II HC, Myo15, Myo2, MyoII, NMM, NMMII, ZIP, Zip, anon-WO0140519.37, l(2)02957, l(2)17F1, myo II, myoII, myosin-II, nmMHC, nmy-2, zip/MyoII, zpr, CG15792 gene product from transcript CG15792-RB, CG15792-PA, CG15792-PB, CG15792-PC, CG15792-PD, CG15792-PE, CG15792-PF, CG15792-PG, CG15792-PH, CG15792-PI, Myo-II heavy chain, MyoII heavy chain, Myosin-2, Myosin-II, cytoplasmic myosin, cytoplasmic myosin II, cytoplasmic myosin heavy chain, cytoplasmic myosin-II, enhancer of broad, lethal (2) 17F1, myosin, myosin 2, myosin HC, myosin II, myosin II heavy chain, myosin heavy chain, myosin heavy chain-cytoplasmic, myosin-heavy-chain-cytoplasmic, myosins II, non muscle myosin, non-muscle myosin, non-muscle myosin II, non-muscle myosin II heavy chain, non-muscle myosin heavy-chain, non-muscle myosin-II, nonmuscle myosin II, nonmuscle myosin II heavy chain, nonmuscle myosin II heavychain, nonmuscle myosin heavy chain, nonmuscle myosin-II, nonmuscle myosin-II heavy chain, zip-PA, zip-PB, zip-PC, zip-PD, zip-PE, zip-PF, zip-PG, zip-PH, zip-PI, zipper heavy chain
Species: fruit fly
Publications125 found, 100 shown here
- Myosin-dependent junction remodelling controls planar cell intercalation and axis elongationClaire Bertet
Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
Nature 429:667-71. 2004..b>Myosin II is specifically enriched in disassembling junctions, and its planar polarized localization and activity are ..
- Morphogenesis in Drosophila requires nonmuscle myosin heavy chain functionP E Young
Department of Cellular and Developmental Biology, Harvard Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
Genes Dev 7:29-41. 1993..are allelic to previously identified, recessive, embryonic-lethal zipper mutations and thereby identify nonmuscle myosin heavy chain as the zipper gene product...
- folded gastrulation, cell shape change and the control of myosin localizationRachel E Dawes-Hoang
Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, NJ 08544, USA
Development 132:4165-78. 2005..protein is apically polarized, making this the earliest polarized component of a pathway that ultimately drives myosin to the apical side of the cell...
- Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probesN H Patel
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
Methods Cell Biol 44:445-87. 1994
- Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulationM G Ricos
Drosophila Neurobiology Laboratory and Glaxo IMCB Group, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
J Cell Sci 112:1225-35. 1999..Signaling in the transforming-growth-factor-beta-like pathway is mediated by Dcdc42, and acts during the closure process to control the mechanics of the migration process, most likely via its putative effector kinase DPAK...
- Patterned gene expression directs bipolar planar polarity in DrosophilaJennifer A Zallen
Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
Dev Cell 6:343-55. 2004..This polarity consists of an enrichment of nonmuscle myosin II at A-P cell borders and Bazooka/PAR-3 protein at the reciprocal D-V cell borders...
- The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblastsClaudia Petritsch
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 4:273-81. 2003..Here we report that Miranda localization requires the unconventional myosin VI Jaguar (Jar)...
- Mechanisms of epithelial fusion and repairA Jacinto
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Nat Cell Biol 3:E117-23. 2001..We are also gaining insight into the nature of the brakes and stop signals, and the mechanisms by which the confronting epithelial sheets knit together to form a seam...
- Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesionShu Yi Wei
Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
Dev Cell 8:493-504. 2005..Finally, cells lacking either Echinoid or DE-Cadherin accumulate a high density of the reciprocal protein, further suggesting that Echinoid and DE-Cadherin play similar and complementary roles in cell adhesion...
- Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesisLaura E Swan
European Neuroscience Institute Göttingen, Gottingen, Germany
EMBO J 25:3640-51. 2006..We propose that Ed and DGrip form a signaling complex, where competition between N-terminal and the C-terminal PDZDs of DGrip for Ed binding controls signaling function...
- Multicellular rosette formation links planar cell polarity to tissue morphogenesisJ Todd Blankenship
Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
Dev Cell 11:459-70. 2006..We find that planar polarity in the Drosophila embryo is established through a sequential enrichment of actin-myosin cables and adherens junction proteins in complementary surface domains...
- Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genesJasmin Kirchner
Department of Zoology, University of Oxford, Oxford, United Kingdom
Genetics 176:273-81. 2007..PP1 beta 9C (flapwing) encodes the fourth PP1c gene and has a specific and nonredundant function as a nonmuscle myosin phosphatase. PP1 alpha 87B is the major form and contributes approximately 80% of the total PP1 activity...
- Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in DrosophilaKaren L Pope
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
Development 135:2227-38. 2008..As amnioserosa cells elongate, they maintain their original cell-cell contacts and develop planar polarity. Myosin II localizes to anterior-posterior contacts, while the polarity protein Bazooka (PAR-3) localizes to dorsoventral ..
- Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 functionStephanie Saja
Department of Biology, The College of Charleston, 66 George Street, Charleston, SC 29424, USA
Neurobiol Dis 40:135-45. 2010..This work lays the groundwork for further experimental exploration of these processes to better understand their contributions to the INCL disease process...
- The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and EnabledWangsun Choi
Department of Biology, University of North Carolina at Chapel Hill, USA
Mol Biol Cell 22:2010-30. 2011..Pyd loss does not dramatically affect AJ protein localization or initial localization of actin and myosin during dorsal closure. However, Pyd loss does affect several cell behaviors that drive dorsal closure...
- Anillin, a contractile ring protein that cycles from the nucleus to the cell cortexC M Field
Department of Biochemistry and Biophysics, University of California, San Francisco Medical Center 94143 0448, USA
J Cell Biol 131:165-78. 1995..cytoplasm and cortex, and during anaphase-telophase it becomes highly enriched in the cleavage furrow along with myosin II. In the syncytial embryo, anillin, along with myosin-II, is enriched in cortical areas undergoing cell cycle ..
- puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in DrosophilaE Martin-Blanco
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
Genes Dev 12:557-70. 1998....
- Regulated expression of nullo is required for the formation of distinct apical and basal adherens junctions in the Drosophila blastodermC Hunter
Howard Hughes Medical Institute, Molecular Biology Department, Princeton University, Princeton, New Jersey 08540, USA
J Cell Biol 150:391-401. 2000..These observations reveal differences in the formation of the apical and basal junctions, and offer insight into the role of Nullo in basal junction formation...
- Drosophila myosin phosphatase and its role in dorsal closureTomoaki Mizuno
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
Development 129:1215-23. 2002Myosin phosphatase negatively regulates nonmuscle myosin II through dephosphorylation of the myosin regulatory light chain (MRLC)...
- Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transportClaudia S Barros
Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
Dev Cell 5:829-40. 2003..Here we show that nonmuscle myosin II regulates asymmetric cell division by an unexpected mechanism, excluding determinants from the apical ..
- Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in DrosophilaCaroline Laplante
Department of Biology, McGill University, 1205 Doctor Penfield Avenue, Montreal, QC H3A 1B1, Canada
Development 133:3255-64. 2006..We propose that local modulation of the cytoskeleton at Ed expression borders may represent a general mechanism for promoting epithelial morphogenesis...
- Native nonmuscle myosin II stability and light chain binding in Drosophila melanogasterJosef D Franke
Department of Biology, Duke University, Durham, North Carolina 27708, USA
Cell Motil Cytoskeleton 63:604-22. 2006..By immunodepletion we find that the majority of both light chains are associated with the nonmuscle myosin II heavy chain but pools of free light chain and/or light chain bound to other proteins are present...
- Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesisP E Young
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
Development 111:1-14. 1991..with both whole immune serum and affinity-purified antibodies directed against Drosophila non-muscle myosin heavy chain. They are not detected in embryos stained with anti-Drosophila muscle myosin antiserum or with preimmune ..
- Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in DrosophilaP J Gotwals
Department of Molecular and Cellular Biology, University of California, Berkeley 94720
Genetics 127:747-59. 1991..b>Enhancer of broad (E(br)) was identified as a dominant enhancer of the br1 allele of the BR-C and is a recessive lethal...
- Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene familyD P Kiehart
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02128
EMBO J 8:913-22. 1989..Flies also contain a cytoplasmic myosin heavy chain polypeptide that by immunological and peptide mapping criteria is clearly different from the major ..
- Cytoplasmic myosin from Drosophila melanogasterD P Kiehart
J Cell Biol 103:1517-25. 1986..One-dimensional peptide maps of SDS PAGE purified myosin heavy chain confirm these structural data...
- Zipper encodes a putative integral membrane protein required for normal axon patterning during Drosophila neurogenesisD B Zhao
Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, FRG
EMBO J 7:1115-9. 1988..We have found that the zipper (zip) gene, initially identified on the basis of a defective larval cuticle in zip mutant embryos, is possibly involved ..
- The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eyeJ R Riesgo-Escovar
Zoologisches Institut, Universitat Zurich, Switzerland
Genes Dev 10:2759-68. 1996..Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that requires MAP kinase and DJun function...
- JNK signaling and morphogenesis in DrosophilaS Noselli
Centre de Biologie du Developpement, UMR 5547 CNRS, Toulouse, France
Trends Genet 14:33-8. 1998
- Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesisS R Halsell
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genetics 148:1845-63. 1998..The nonmuscle myosin heavy chain is encoded by a single locus, zipper...
- The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in DrosophilaK J Blake
Department of Anatomy, University of Connecticut Health Center, Farmington, Connecticut, 06030, USA
Dev Biol 203:177-88. 1998..Furthermore, mutations of zipper, the gene encoding the nonmuscle myosin heavy chain, exhibit mutant phenotypes in most of the same tissues affected by rib and raw, and many of the ..
- Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesisN Harden
Glaxo IMCB and Drosophila Neurobiology Laboratories, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
J Cell Sci 112:273-84. 1999..Rather, our results suggest that while all &Rgr; subfamily p21s tested are required for dorsal closure, they act largely in parallel...
- Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in DrosophilaD C Zarnescu
Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Cell Biol 146:1075-86. 1999....
- Functional analysis of the Drosophila diaphanous FH protein in early embryonic developmentK Afshar
Department of Biology, Center for Molecular Genetics, University of California, San Diego, La Jolla CA 92093 0634, USA
Development 127:1887-97. 2000..In addition, the dia mutant phenotype reveals a role for Diaphanous in recruitment of myosin II, anillin and Peanut to the cortical region between actin caps...
- Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesisS R Halsell
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genetics 155:1253-65. 2000A dynamic actomyosin cytoskeleton drives many morphogenetic events. Conventional nonmuscle myosin-II (myosin) is a key chemomechanical motor that drives contraction of the actin cytoskeleton...
- The Drosophila tumor suppressor gene lethal(2)giant larvae is required for the emission of the Decapentaplegic signalN Arquier
Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France
Development 128:2209-20. 2001..is required for the dpp-dependent transcriptional activation of zipper (zip), which encodes the non-muscle myosin heavy chain (NMHC), in the dorsalmost ectodermal cells - the leading edge cells...
- zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formationJ W Bloor
Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, B330 LSRC Building, Research Drive, Durham, North Carolina 27708 1000, USA
Dev Biol 239:215-28. 2001Nonmuscle myosin-II is a key motor protein that drives cell shape change and cell movement. Here, we analyze the function of nonmuscle myosin-II during Drosophila embryonic myogenesis...
- Dynamic analysis of actin cable function during Drosophila dorsal closureAntonio Jacinto
Department of Anatomy andDevelopmental Biology, University College London, United Kingdom
Curr Biol 12:1245-50. 2002..GFP-actin-expressing embryos in which the cable is disrupted by modulating Rho1 signaling or by loss of non-muscle myosin (Zipper) function. We show that the cable serves a dual role during dorsal closure...
- Roles of myosin phosphatase during Drosophila developmentChange Tan
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Development 130:671-81. 2003Myosins are a superfamily of actin-dependent molecular motor proteins, among which the bipolar filament forming myosins II have been the most studied...
- Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetryRoger Albertson
Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, OR 97403, USA
Nat Cell Biol 5:166-70. 2003..We conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts...
- Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryosAnne Royou
CNRS Centre de Génétique Moléculaire, 91198 Gif sur Yvette, France
Mol Biol Cell 15:838-50. 2004..Both involve actin cytoskeleton rearrangements, and both have myosin II at or near the forming furrow...
- Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesisRobert E Ward
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5331, USA
Genetics 165:1397-415. 2003....
- Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosisGuang Chao Chen
Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Curr Biol 14:309-13. 2004..Together, these findings indicate a link between Rho-LIMK signaling and steroid hormone-induced gene expression in the context of metamorphosis and thereby establish a novel role for the Rho GTPase in development...
- Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epitheliumArnold Lee
Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Mol Biol Cell 15:3285-95. 2004..chain Spaghetti squash rather than another potential substrate, Moesin, and that it requires the nonmuscle myosin II heavy chain Zipper...
- Spatial pattern of nonmuscle myosin-II distribution during the development of the Drosophila compound eye and implications for retinal morphogenesisOtto Baumann
Institut für Biochemie und Biologie, Zoophysiologie, Universitat Potsdam, D 14415 Potsdam, Germany
Dev Biol 269:519-33. 2004Nonmuscle myosin-II is a motor protein that drives cell movement and changes in cell shape during tissue and organ development...
- The essential role of PP1beta in Drosophila is to regulate nonmuscle myosinNatalia Vereshchagina
Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
Mol Biol Cell 15:4395-405. 2004Reversible phosphorylation of myosin regulatory light chain (MRLC) is a key regulatory mechanism controlling myosin activity and thus regulating the actin/myosin cytoskeleton...
- Drosophila citron kinase is required for the final steps of cytokinesisValeria Naim
Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185 Rome, Italy
Mol Biol Cell 15:5053-63. 2004....
- Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent mannerStephen L Rogers
Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
Curr Biol 14:1827-33. 2004..S2 cells as a model system, we show that DRhoGEF2 induces contractile cell shape changes by stimulating myosin II via the Rho1 pathway...
- RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisationJörg Grosshans
ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Development 132:1009-20. 2005..Our results support a model in which RhoGEF2 and dia control position, shape and stability of the forming furrow canal by spatially restricted assembly of actin filaments required for the proper infolding of the plasma membrane...
- Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesisSara O Dean
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 102:13473-8. 2005The correct localization of myosin II to the equatorial cortex is crucial for proper cell division...
- Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesisLeonard Dobens
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th Street, Charlestown, MA 02129, USA
Dev Biol 287:425-37. 2005....
- Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closureJosef D Franke
Department of Biology, Developmental Cell and Molecular Biology Group, Duke University, Durham, North Carolina 27708, USA
Curr Biol 15:2208-21. 2005..Closure requires that four forces, derived from distinct tissues, be precisely balanced. The proteins responsible for generating each of the forces have not been determined...
- Coordinated cell-shape changes control epithelial movement in zebrafish and DrosophilaMathias Köppen
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
Development 133:2671-81. 2006..Here evidence is provided for a conserved mechanism of local actin and myosin 2 recruitment during theses events...
- The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invaginationVéronique Brodu
Institut de Biologia Molecular de Barcelona CSIC and Institut de Recerca Biomedica, Parc Cientific de Barcelona, 08028 Barcelona, Spain
Genes Dev 20:1817-28. 2006..cell behavior at invagination and show that it is associated with, and requires, a distinct recruitment of Myosin II to the apical surface of cells at the invaginating edge...
- Planar polarization of the denticle field in the Drosophila embryo: roles for Myosin II (zipper) and fringeJames W Walters
Department of Cell and Developmental Biology, University of Pennsylvania Medical Center, Philadelphia 19104 6058, USA
Dev Biol 297:323-39. 2006..Cells of the prospective denticle field, but not the adjacent smooth field, align precisely. This requires Myosin II (zipper) function, and we find that Myosin II is enriched in a bipolar manner, across the parasegment, on both ..
- Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesisSergio Simoes
Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Portugal
Development 133:4257-67. 2006....
- Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in DrosophilaDonald T Fox
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Development 134:567-78. 2007..Although these regulators act to promote stable myosin accumulation and apical cell constriction, loss-of-function phenotypes for each of these pathway members is not ..
- The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of DrosophilaJasmin Kirchner
Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
Genetics 175:1741-9. 2007..the nonmuscle myosin regulatory light chain, Spaghetti Squash (Sqh); this inactivates the nonmuscle myosin heavy chain, Zipper (Zip)...
- Myosin II regulates complex cellular arrangement and epithelial architecture in DrosophilaLuis M Escudero
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Dev Cell 13:717-29. 2007Remodeling epithelia is a primary driver of morphogenesis. Here, we report a central role of myosin II in regulating several aspects of complex epithelial architecture in the Drosophila eye imaginal disc...
- Filament-dependent and -independent localization modes of Drosophila non-muscle myosin IISu Ling Liu
Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
J Biol Chem 283:380-7. 2008..and a novel fluorescence resonance energy transfer assay, that assembly of the Drosophila non-muscle myosin II heavy chain, zipper, is mediated by a 90-residue region (1849-1940) of the coiled-coil tail domain...
- Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesisCatarina C F Homem
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Development 135:1005-18. 2008..This revealed an unexpected role in regulating myosin levels and activity at adherens junctions during cell shape change, suggesting that Diaphanous helps coordinate ..
- Local actin-dependent endocytosis is zygotically controlled to initiate Drosophila cellularizationAnna Marie Sokac
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
Dev Cell 14:775-86. 2008..We propose that developmentally regulated endocytosis can coordinate actin/PM remodeling to directly drive furrow dynamics during morphogenesis...
- Pulsed contractions of an actin-myosin network drive apical constrictionAdam C Martin
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
Nature 457:495-9. 2009..thought to be driven by the continuous purse-string-like contraction of a circumferential actin and non-muscle myosin-II (myosin) belt underlying adherens junctions...
- Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epitheliaStephen J Warner
Department of Medicine, Washington University, St Louis, MO 63110, USA
J Cell Biol 185:1111-25. 2009..In contrast, depletion of Rho1 in single cells decreases apical tension, and Rok and myosin are necessary, while Dia function also contributes, downstream of Rho1 to sustain apical cell tension.
- The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constrictionJessica K Sawyer
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Biol 186:57-73. 2009..Instead, Cno localizes to AJs by a Rap1- and actin-dependent mechanism. These data suggest that Cno regulates linkage between AJs and the actin cytoskeleton during morphogenesis...
- Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundaryKatharina P Landsberg
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Curr Biol 19:1950-5. 2009..Cell bond tension is decreased in the presence of Y-27632 , an inhibitor of Rho-kinase whose main effector is Myosin II . Simulations using a vertex model  demonstrate that a 2...
- An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryosBruno Monier
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Nat Cell Biol 12:60-5; sup pp 1-9. 2010..When MyoII (non-muscle myosin II) function is inhibited, including locally at the cable by chromophore-assisted laser inactivation (CALI), in ..
- Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healingSeung Hee Baek
Department of Biology, Yonsei University, 262 Seongsanno, Seodaemun gu, Seoul 120 749, Republic of Korea
Biochem Biophys Res Commun 394:488-92. 2010A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis...
- Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epitheliumRobert P Simone
University of Pennsylvania Medical School, Department of Cell and Developmental Biology, 421 Curie Boulevard, Philadelphia, PA 19104 6048, USA
Development 137:1385-94. 2010..Additionally, we show that non-muscle Myosin II and the polarity proteins Discs large (Dlg) and Bazooka are enriched along cell interfaces in a complex but ..
- The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epitheliaStephen J Warner
Department of Medicine, BRIGHT Institute, Washington University School of Medicine, St Louis, MO 63110, USA
Curr Biol 20:677-86. 2010..We considered whether disruption of the various polarity complexes could provide signals identifying damaged epithelial cells and thus lead to apoptosis-induced compensatory proliferation...
- The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in DrosophilaDaryl J V David
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
Development 137:1645-55. 2010..We have analyzed the relationship between myosin and the polarity regulators Par-6, aPKC and Bazooka (Par-3) (the PAR complex) during amnioserosa apical ..
- Determinants of myosin II cortical localization during cytokinesisRyota Uehara
Physiology Course, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
Curr Biol 20:1080-5. 2010..accumulation at three different stages: (1) turnover of thick filaments throughout the cell cycle, (2) myosin heavy chain-based control of myosin assembly at the metaphase-anaphase transition, and (3) redistribution and/or ..
- Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesisJosef D Franke
Department of Biology, Duke University, Durham, NC 27708, USA
Dev Biol 345:117-32. 2010Metazoan development involves a myriad of dynamic cellular processes that require cytoskeletal function. Nonmuscle myosin II plays essential roles in embryonic development; however, knowledge of its role in post-embryonic development, ..
- Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongationSérgio de Matos Simões
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
Dev Cell 19:377-88. 2010..We show that Bazooka/Par-3 (Baz) is required for the planar polarized distribution of myosin II and adherens junction proteins and polarized intercalary behavior is disrupted in baz mutants...
- Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closureCaroline Laplante
Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
J Cell Biol 192:335-48. 2011..The planar polarized distribution of Ed in the DME cells thus provides a spatial cue that polarizes the DME cell actin cytoskeleton, defining the epidermal leading edge and establishing its contractile properties...
- Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signalingY Jiang
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Oncogene 30:3248-60. 2011..Mechanistically, we show that sds22 prevents cell invasion and metastasis by inhibiting myosin II and Jun N-terminal kinase (JNK) activity downstream of PP1...
- Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migrationPralay Majumder
Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Curr Biol 22:363-72. 2012..of Drosophila border cells, a genetically tractable model for collective cell migration, requires nonmuscle myosin-II (Myo-II)...
- Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constrictionDaryl J V David
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
Development 140:4719-29. 2013..This later impact of aPKC inhibition is supported by mathematical modelling of the system. Overall, this work illustrates how shifting chemical signals can tune actomyosin network behaviour during development...
- Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongationBing He
1 Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA 2
Nature 508:392-6. 2014....
- Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeletonC G Winter
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 105:81-91. 2001..is regulating the phosphorylation of nonmuscle myosin regulatory light chain, and hence the activity of myosin II. Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with ..
- Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in DrosophilaD L Silver
Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Cell 107:831-41. 2001..Ectopic expression of either UPD or JAK is sufficient to induce extra epithelial cells to migrate. Thus, a localized signal activates the JAK/STAT pathway in neighboring epithelial cells, causing them to become invasive...
- Segment boundary formation in Drosophila embryosCamilla W Larsen
National Institute for Medical Research, The Ridgeway Mill Hill, London NW7 1AA, UK
Development 130:5625-35. 2003..In addition, Wingless signalling at the anterior of the domains of engrailed (and hedgehog) expression represses groove formation and thus ensures that segment boundaries form only at the posterior...
- Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesisCynthia A Bayer
Department of Biology, University of Central Florida, Orlando, Florida 32816 2368, USA
Genetics 165:1417-32. 2003..RhoA enhance leg and wing defects associated with mutations in zipper, the gene encoding the heavy chain of nonmuscle myosin II. We demonstrate here that mutations affecting the RhoA signaling pathway also interact genetically with ..
- Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division sitePier Paolo D'Avino
Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
J Cell Sci 121:1151-8. 2008Anillin, one of the first factors recruited to the cleavage site during cytokinesis, interacts with actin, myosin II and septins, and is essential for proper organization of the actomyosin contractile ring...
- hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movementB Glise
Centre de Biologie du Developpement, Centre National de la Recherche Scientifique, Toulouse, France
Cell 83:451-61. 1995..These data suggest that hep functions in a novel Drosophila MAPK pathway, controlling puckered expression and morphogenetic activity of the dorsal epidermis...
- DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishmentAstrid G Petzoldt
Institute of Biology Valrose, University of Nice Sophia Antipolis, UMR7277 CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France
Development 139:1874-84. 2012..Recent work in Drosophila has identified a novel situs inversus gene encoding the unconventional type ID myosin (MyoID)...
- Drosophila morphogenesis: movements behind the edgeE Knust
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatstrasse 1, 40225 Dusseldorf, Germany
Curr Biol 7:R558-61. 1997..Coordinated cell movements during development require extensive exchange of information between the cells involved. Recent results suggest a connection between two signalling pathways during dorsal closure in the Drosophila embryo...
- High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation ratesC Schlotterer
Institut fur Tierzucht und Genetik, Vienna, Austria
Mol Biol Evol 15:1269-74. 1998..The allele-specific mutation rate of 3.0 x 10(-4) per generation is within the range of mammalian mutation rates. Future microsatellite analyses will have to account for the dramatic differences in allele-specific mutation rates...
- ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeletonK J Blake
Department of Anatomy, MC 3405, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Dev Genes Evol 209:555-9. 1999..Mutations of zip, which encodes the nonmuscle myosin heavy chain, suppress the phenotypes of rib and raw, suggesting that rib and raw are not directly required for ..
- A targeted gene silencing technique shows that Drosophila myosin VI is required for egg chamber and imaginal disc morphogenesisW Deng
Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Edinburgh EH9 3JR, UK
J Cell Sci 112:3677-90. 1999We report that Drosophila unconventional myosin VI, encoded by Myosin heavy chain at 95F (Mhc95F), is required for both imaginal disc and egg chamber morphogenesis...
- Microtubules and mitotic cycle phase modulate spatiotemporal distributions of F-actin and myosin II in Drosophila syncytial blastoderm embryosV E Foe
Department of Zoology, University of Washington, Seattle WA 98195 1800, USA
Development 127:1767-87. 2000..They provide evidence that filamentous actin and cytoplasmic myosin II are transported along microtubules towards microtubule plus ends, with actin and myosin exhibiting ..
- Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in fliesZ Su
Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University Medical Center, and University Programs in Genetics and Cellular and Molecular Biology, Durham, North Carolina 27710, USA
Biochemistry 40:3606-14. 2001..Thus, the nonmuscle myosin heavy chain in Drosophila, which is encoded by the zipper gene, appears to be similar to rabbit nonmuscle myosin-..
- Posterior midgut epithelial cells differ in their organization of the membrane skeleton from other drosophila epitheliaO Baumann
Institut für Biochemie und Biologie, Universitat Potsdam, Potsdam, 14471, Germany
Exp Cell Res 270:176-87. 2001..Finally, despite the absence of zonulae adherentes, F-actin, beta(H)-spectrin, and nonmuscle myosin-II are enriched in the midlateral region...
- A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesisW Gregory Somers
Centre for the Molecular Genetics of Development, Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
Dev Cell 4:29-39. 2003....
- Nonmuscle myosin promotes cytoplasmic localization of PBXHe Huang
McGill Cancer Centre, Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1Y6
Mol Cell Biol 23:3636-45. 2003..additional proteins directing PBX subcellular localization, we identified a fragment of murine nonmuscle myosin II heavy chain B (NMHCB)...
- Myosins motor MirandaDaniel P Kiehart
Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, Durham, NC 27708, USA
Mol Cell 12:1346-7. 2003New evidence shows that myosin motors drive the spatial segregation of cell fate determinants during asymmetric cell division. How they do so remains a mystery.
- Anillin binds nonmuscle myosin II and regulates the contractile ringAaron F Straight
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Biol Cell 16:193-201. 2005We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation...
- The centrosomal protein CP190 regulates myosin function during early Drosophila developmentS Chodagam
The Gurdon Institute, Department of Genetics, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
Curr Biol 15:1308-13. 2005Centrosomes are the main microtubule (MT)-organizing centers in animal cells, but they also influence the actin/myosin cytoskeleton...
- Rho-kinase controls cell shape changes during cytokinesisGilles R X Hickson
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
Curr Biol 16:359-70. 2006..To explore the initiation of cytokinesis, we focused on the earliest cell shape change, cell elongation, which occurs during anaphase B and prior to cytokinetic furrowing...
- Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesisMuriel Grammont
Institut National de la Sante et de la Recherche Medicale, Unité 384, Clermont Ferrand F 63001, France
J Cell Biol 177:139-50. 2007..This results in abnormal StC flattening and delayed MBFC displacement. Additionally, accumulation of the myosin II heavy chain Zipper is delayed at the AJs that require disassembly...
- PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTIONRichard Carthew; Fiscal Year: 2005..abstract_text> ..