zip

Summary

Gene Symbol: zip
Description: zipper
Alias: CG15792, DROMHC, Dm nmII, Dmel\CG15792, DmnmII, Dronm-MII, E(br), MHC, Mhc-c, Mhc-c[1], Myo, Myo II, Myo-II, Myo-II HC, Myo15, Myo2, MyoII, NMM, NMMII, ZIP, Zip, anon-WO0140519.37, l(2)02957, l(2)17F1, myo II, myoII, myosin-II, nmMHC, nmy-2, zip/MyoII, zpr, CG15792 gene product from transcript CG15792-RB, CG15792-PA, CG15792-PB, CG15792-PC, CG15792-PD, CG15792-PE, CG15792-PF, CG15792-PG, CG15792-PH, CG15792-PI, Myo-II heavy chain, MyoII heavy chain, Myosin-2, Myosin-II, cytoplasmic myosin, cytoplasmic myosin II, cytoplasmic myosin heavy chain, cytoplasmic myosin-II, enhancer of broad, lethal (2) 17F1, myosin, myosin 2, myosin HC, myosin II, myosin II heavy chain, myosin heavy chain, myosin heavy chain-cytoplasmic, myosin-heavy-chain-cytoplasmic, myosins II, non muscle myosin, non-muscle myosin, non-muscle myosin II, non-muscle myosin II heavy chain, non-muscle myosin heavy-chain, non-muscle myosin-II, nonmuscle myosin II, nonmuscle myosin II heavy chain, nonmuscle myosin II heavychain, nonmuscle myosin heavy chain, nonmuscle myosin-II, nonmuscle myosin-II heavy chain, zip-PA, zip-PB, zip-PC, zip-PD, zip-PE, zip-PF, zip-PG, zip-PH, zip-PI, zipper heavy chain
Species: fruit fly

Top Publications

  1. ncbi Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
    Claire Bertet
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Nature 429:667-71. 2004
  2. ncbi Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function
    P E Young
    Department of Cellular and Developmental Biology, Harvard Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 7:29-41. 1993
  3. ncbi folded gastrulation, cell shape change and the control of myosin localization
    Rachel E Dawes-Hoang
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, NJ 08544, USA
    Development 132:4165-78. 2005
  4. ncbi Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
    N H Patel
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Methods Cell Biol 44:445-87. 1994
  5. ncbi Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation
    M G Ricos
    Drosophila Neurobiology Laboratory and Glaxo IMCB Group, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    J Cell Sci 112:1225-35. 1999
  6. ncbi Patterned gene expression directs bipolar planar polarity in Drosophila
    Jennifer A Zallen
    Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
    Dev Cell 6:343-55. 2004
  7. ncbi The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts
    Claudia Petritsch
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 4:273-81. 2003
  8. ncbi Mechanisms of epithelial fusion and repair
    A Jacinto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 3:E117-23. 2001
  9. ncbi Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion
    Shu Yi Wei
    Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
    Dev Cell 8:493-504. 2005
  10. pmc Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis
    Laura E Swan
    European Neuroscience Institute Göttingen, Gottingen, Germany
    EMBO J 25:3640-51. 2006

Research Grants

Scientific Experts

Detail Information

Publications125 found, 100 shown here

  1. ncbi Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
    Claire Bertet
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Nature 429:667-71. 2004
    ..b>Myosin II is specifically enriched in disassembling junctions, and its planar polarized localization and activity are ..
  2. ncbi Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function
    P E Young
    Department of Cellular and Developmental Biology, Harvard Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 7:29-41. 1993
    ..are allelic to previously identified, recessive, embryonic-lethal zipper mutations and thereby identify nonmuscle myosin heavy chain as the zipper gene product...
  3. ncbi folded gastrulation, cell shape change and the control of myosin localization
    Rachel E Dawes-Hoang
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, NJ 08544, USA
    Development 132:4165-78. 2005
    ..protein is apically polarized, making this the earliest polarized component of a pathway that ultimately drives myosin to the apical side of the cell...
  4. ncbi Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
    N H Patel
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Methods Cell Biol 44:445-87. 1994
  5. ncbi Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation
    M G Ricos
    Drosophila Neurobiology Laboratory and Glaxo IMCB Group, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    J Cell Sci 112:1225-35. 1999
    ..Signaling in the transforming-growth-factor-beta-like pathway is mediated by Dcdc42, and acts during the closure process to control the mechanics of the migration process, most likely via its putative effector kinase DPAK...
  6. ncbi Patterned gene expression directs bipolar planar polarity in Drosophila
    Jennifer A Zallen
    Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
    Dev Cell 6:343-55. 2004
    ..This polarity consists of an enrichment of nonmuscle myosin II at A-P cell borders and Bazooka/PAR-3 protein at the reciprocal D-V cell borders...
  7. ncbi The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts
    Claudia Petritsch
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 4:273-81. 2003
    ..Here we report that Miranda localization requires the unconventional myosin VI Jaguar (Jar)...
  8. ncbi Mechanisms of epithelial fusion and repair
    A Jacinto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 3:E117-23. 2001
    ..We are also gaining insight into the nature of the brakes and stop signals, and the mechanisms by which the confronting epithelial sheets knit together to form a seam...
  9. ncbi Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion
    Shu Yi Wei
    Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
    Dev Cell 8:493-504. 2005
    ..Finally, cells lacking either Echinoid or DE-Cadherin accumulate a high density of the reciprocal protein, further suggesting that Echinoid and DE-Cadherin play similar and complementary roles in cell adhesion...
  10. pmc Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis
    Laura E Swan
    European Neuroscience Institute Göttingen, Gottingen, Germany
    EMBO J 25:3640-51. 2006
    ..We propose that Ed and DGrip form a signaling complex, where competition between N-terminal and the C-terminal PDZDs of DGrip for Ed binding controls signaling function...
  11. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
    ..We find that planar polarity in the Drosophila embryo is established through a sequential enrichment of actin-myosin cables and adherens junction proteins in complementary surface domains...
  12. pmc Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes
    Jasmin Kirchner
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Genetics 176:273-81. 2007
    ..PP1 beta 9C (flapwing) encodes the fourth PP1c gene and has a specific and nonredundant function as a nonmuscle myosin phosphatase. PP1 alpha 87B is the major form and contributes approximately 80% of the total PP1 activity...
  13. doi Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in Drosophila
    Karen L Pope
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    Development 135:2227-38. 2008
    ..As amnioserosa cells elongate, they maintain their original cell-cell contacts and develop planar polarity. Myosin II localizes to anterior-posterior contacts, while the polarity protein Bazooka (PAR-3) localizes to dorsoventral ..
  14. pmc Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function
    Stephanie Saja
    Department of Biology, The College of Charleston, 66 George Street, Charleston, SC 29424, USA
    Neurobiol Dis 40:135-45. 2010
    ..This work lays the groundwork for further experimental exploration of these processes to better understand their contributions to the INCL disease process...
  15. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
    ..Pyd loss does not dramatically affect AJ protein localization or initial localization of actin and myosin during dorsal closure. However, Pyd loss does affect several cell behaviors that drive dorsal closure...
  16. pmc Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex
    C M Field
    Department of Biochemistry and Biophysics, University of California, San Francisco Medical Center 94143 0448, USA
    J Cell Biol 131:165-78. 1995
    ..cytoplasm and cortex, and during anaphase-telophase it becomes highly enriched in the cleavage furrow along with myosin II. In the syncytial embryo, anillin, along with myosin-II, is enriched in cortical areas undergoing cell cycle ..
  17. pmc puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
    E Martin-Blanco
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Genes Dev 12:557-70. 1998
    ....
  18. pmc Regulated expression of nullo is required for the formation of distinct apical and basal adherens junctions in the Drosophila blastoderm
    C Hunter
    Howard Hughes Medical Institute, Molecular Biology Department, Princeton University, Princeton, New Jersey 08540, USA
    J Cell Biol 150:391-401. 2000
    ..These observations reveal differences in the formation of the apical and basal junctions, and offer insight into the role of Nullo in basal junction formation...
  19. ncbi Drosophila myosin phosphatase and its role in dorsal closure
    Tomoaki Mizuno
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Development 129:1215-23. 2002
    Myosin phosphatase negatively regulates nonmuscle myosin II through dephosphorylation of the myosin regulatory light chain (MRLC)...
  20. ncbi Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport
    Claudia S Barros
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Dev Cell 5:829-40. 2003
    ..Here we show that nonmuscle myosin II regulates asymmetric cell division by an unexpected mechanism, excluding determinants from the apical ..
  21. ncbi Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in Drosophila
    Caroline Laplante
    Department of Biology, McGill University, 1205 Doctor Penfield Avenue, Montreal, QC H3A 1B1, Canada
    Development 133:3255-64. 2006
    ..We propose that local modulation of the cytoskeleton at Ed expression borders may represent a general mechanism for promoting epithelial morphogenesis...
  22. ncbi Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster
    Josef D Franke
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Cell Motil Cytoskeleton 63:604-22. 2006
    ..By immunodepletion we find that the majority of both light chains are associated with the nonmuscle myosin II heavy chain but pools of free light chain and/or light chain bound to other proteins are present...
  23. ncbi Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis
    P E Young
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
    Development 111:1-14. 1991
    ..with both whole immune serum and affinity-purified antibodies directed against Drosophila non-muscle myosin heavy chain. They are not detected in embryos stained with anti-Drosophila muscle myosin antiserum or with preimmune ..
  24. pmc Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in Drosophila
    P J Gotwals
    Department of Molecular and Cellular Biology, University of California, Berkeley 94720
    Genetics 127:747-59. 1991
    ..b>Enhancer of broad (E(br)) was identified as a dominant enhancer of the br1 allele of the BR-C and is a recessive lethal...
  25. pmc Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family
    D P Kiehart
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02128
    EMBO J 8:913-22. 1989
    ..Flies also contain a cytoplasmic myosin heavy chain polypeptide that by immunological and peptide mapping criteria is clearly different from the major ..
  26. pmc Cytoplasmic myosin from Drosophila melanogaster
    D P Kiehart
    J Cell Biol 103:1517-25. 1986
    ..One-dimensional peptide maps of SDS PAGE purified myosin heavy chain confirm these structural data...
  27. pmc Zipper encodes a putative integral membrane protein required for normal axon patterning during Drosophila neurogenesis
    D B Zhao
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, FRG
    EMBO J 7:1115-9. 1988
    ..We have found that the zipper (zip) gene, initially identified on the basis of a defective larval cuticle in zip mutant embryos, is possibly involved ..
  28. ncbi The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
    J R Riesgo-Escovar
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 10:2759-68. 1996
    ..Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that requires MAP kinase and DJun function...
  29. ncbi JNK signaling and morphogenesis in Drosophila
    S Noselli
    Centre de Biologie du Developpement, UMR 5547 CNRS, Toulouse, France
    Trends Genet 14:33-8. 1998
  30. pmc Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis
    S R Halsell
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 148:1845-63. 1998
    ..The nonmuscle myosin heavy chain is encoded by a single locus, zipper...
  31. ncbi The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila
    K J Blake
    Department of Anatomy, University of Connecticut Health Center, Farmington, Connecticut, 06030, USA
    Dev Biol 203:177-88. 1998
    ..Furthermore, mutations of zipper, the gene encoding the nonmuscle myosin heavy chain, exhibit mutant phenotypes in most of the same tissues affected by rib and raw, and many of the ..
  32. ncbi Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis
    N Harden
    Glaxo IMCB and Drosophila Neurobiology Laboratories, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    J Cell Sci 112:273-84. 1999
    ..Rather, our results suggest that while all &Rgr; subfamily p21s tested are required for dorsal closure, they act largely in parallel...
  33. pmc Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila
    D C Zarnescu
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Cell Biol 146:1075-86. 1999
    ....
  34. ncbi Functional analysis of the Drosophila diaphanous FH protein in early embryonic development
    K Afshar
    Department of Biology, Center for Molecular Genetics, University of California, San Diego, La Jolla CA 92093 0634, USA
    Development 127:1887-97. 2000
    ..In addition, the dia mutant phenotype reveals a role for Diaphanous in recruitment of myosin II, anillin and Peanut to the cortical region between actin caps...
  35. pmc Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis
    S R Halsell
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 155:1253-65. 2000
    A dynamic actomyosin cytoskeleton drives many morphogenetic events. Conventional nonmuscle myosin-II (myosin) is a key chemomechanical motor that drives contraction of the actin cytoskeleton...
  36. ncbi The Drosophila tumor suppressor gene lethal(2)giant larvae is required for the emission of the Decapentaplegic signal
    N Arquier
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France
    Development 128:2209-20. 2001
    ..is required for the dpp-dependent transcriptional activation of zipper (zip), which encodes the non-muscle myosin heavy chain (NMHC), in the dorsalmost ectodermal cells - the leading edge cells...
  37. ncbi zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation
    J W Bloor
    Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, B330 LSRC Building, Research Drive, Durham, North Carolina 27708 1000, USA
    Dev Biol 239:215-28. 2001
    Nonmuscle myosin-II is a key motor protein that drives cell shape change and cell movement. Here, we analyze the function of nonmuscle myosin-II during Drosophila embryonic myogenesis...
  38. ncbi Dynamic analysis of actin cable function during Drosophila dorsal closure
    Antonio Jacinto
    Department of Anatomy andDevelopmental Biology, University College London, United Kingdom
    Curr Biol 12:1245-50. 2002
    ..GFP-actin-expressing embryos in which the cable is disrupted by modulating Rho1 signaling or by loss of non-muscle myosin (Zipper) function. We show that the cable serves a dual role during dorsal closure...
  39. ncbi Roles of myosin phosphatase during Drosophila development
    Change Tan
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Development 130:671-81. 2003
    Myosins are a superfamily of actin-dependent molecular motor proteins, among which the bipolar filament forming myosins II have been the most studied...
  40. ncbi Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
    Roger Albertson
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, OR 97403, USA
    Nat Cell Biol 5:166-70. 2003
    ..We conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts...
  41. pmc Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos
    Anne Royou
    CNRS Centre de Génétique Moléculaire, 91198 Gif sur Yvette, France
    Mol Biol Cell 15:838-50. 2004
    ..Both involve actin cytoskeleton rearrangements, and both have myosin II at or near the forming furrow...
  42. pmc Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis
    Robert E Ward
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5331, USA
    Genetics 165:1397-415. 2003
    ....
  43. ncbi Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis
    Guang Chao Chen
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Biol 14:309-13. 2004
    ..Together, these findings indicate a link between Rho-LIMK signaling and steroid hormone-induced gene expression in the context of metamorphosis and thereby establish a novel role for the Rho GTPase in development...
  44. pmc Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium
    Arnold Lee
    Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Mol Biol Cell 15:3285-95. 2004
    ..chain Spaghetti squash rather than another potential substrate, Moesin, and that it requires the nonmuscle myosin II heavy chain Zipper...
  45. ncbi Spatial pattern of nonmuscle myosin-II distribution during the development of the Drosophila compound eye and implications for retinal morphogenesis
    Otto Baumann
    Institut für Biochemie und Biologie, Zoophysiologie, Universitat Potsdam, D 14415 Potsdam, Germany
    Dev Biol 269:519-33. 2004
    Nonmuscle myosin-II is a motor protein that drives cell movement and changes in cell shape during tissue and organ development...
  46. pmc The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin
    Natalia Vereshchagina
    Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
    Mol Biol Cell 15:4395-405. 2004
    Reversible phosphorylation of myosin regulatory light chain (MRLC) is a key regulatory mechanism controlling myosin activity and thus regulating the actin/myosin cytoskeleton...
  47. pmc Drosophila citron kinase is required for the final steps of cytokinesis
    Valeria Naim
    Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185 Rome, Italy
    Mol Biol Cell 15:5053-63. 2004
    ....
  48. ncbi Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner
    Stephen L Rogers
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
    Curr Biol 14:1827-33. 2004
    ..S2 cells as a model system, we show that DRhoGEF2 induces contractile cell shape changes by stimulating myosin II via the Rho1 pathway...
  49. ncbi RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation
    Jörg Grosshans
    ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Development 132:1009-20. 2005
    ..Our results support a model in which RhoGEF2 and dia control position, shape and stability of the forming furrow canal by spatially restricted assembly of actin filaments required for the proper infolding of the plasma membrane...
  50. pmc Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis
    Sara O Dean
    Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:13473-8. 2005
    The correct localization of myosin II to the equatorial cortex is crucial for proper cell division...
  51. ncbi Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis
    Leonard Dobens
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th Street, Charlestown, MA 02129, USA
    Dev Biol 287:425-37. 2005
    ....
  52. ncbi Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure
    Josef D Franke
    Department of Biology, Developmental Cell and Molecular Biology Group, Duke University, Durham, North Carolina 27708, USA
    Curr Biol 15:2208-21. 2005
    ..Closure requires that four forces, derived from distinct tissues, be precisely balanced. The proteins responsible for generating each of the forces have not been determined...
  53. ncbi Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila
    Mathias Köppen
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Development 133:2671-81. 2006
    ..Here evidence is provided for a conserved mechanism of local actin and myosin 2 recruitment during theses events...
  54. pmc The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination
    Véronique Brodu
    Institut de Biologia Molecular de Barcelona CSIC and Institut de Recerca Biomedica, Parc Cientific de Barcelona, 08028 Barcelona, Spain
    Genes Dev 20:1817-28. 2006
    ..cell behavior at invagination and show that it is associated with, and requires, a distinct recruitment of Myosin II to the apical surface of cells at the invaginating edge...
  55. ncbi Planar polarization of the denticle field in the Drosophila embryo: roles for Myosin II (zipper) and fringe
    James W Walters
    Department of Cell and Developmental Biology, University of Pennsylvania Medical Center, Philadelphia 19104 6058, USA
    Dev Biol 297:323-39. 2006
    ..Cells of the prospective denticle field, but not the adjacent smooth field, align precisely. This requires Myosin II (zipper) function, and we find that Myosin II is enriched in a bipolar manner, across the parasegment, on both ..
  56. ncbi Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis
    Sergio Simoes
    Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Portugal
    Development 133:4257-67. 2006
    ....
  57. ncbi Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila
    Donald T Fox
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 134:567-78. 2007
    ..Although these regulators act to promote stable myosin accumulation and apical cell constriction, loss-of-function phenotypes for each of these pathway members is not ..
  58. pmc The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila
    Jasmin Kirchner
    Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
    Genetics 175:1741-9. 2007
    ..the nonmuscle myosin regulatory light chain, Spaghetti Squash (Sqh); this inactivates the nonmuscle myosin heavy chain, Zipper (Zip)...
  59. ncbi Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila
    Luis M Escudero
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Dev Cell 13:717-29. 2007
    Remodeling epithelia is a primary driver of morphogenesis. Here, we report a central role of myosin II in regulating several aspects of complex epithelial architecture in the Drosophila eye imaginal disc...
  60. ncbi Filament-dependent and -independent localization modes of Drosophila non-muscle myosin II
    Su Ling Liu
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    J Biol Chem 283:380-7. 2008
    ..and a novel fluorescence resonance energy transfer assay, that assembly of the Drosophila non-muscle myosin II heavy chain, zipper, is mediated by a 90-residue region (1849-1940) of the coiled-coil tail domain...
  61. doi Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis
    Catarina C F Homem
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 135:1005-18. 2008
    ..This revealed an unexpected role in regulating myosin levels and activity at adherens junctions during cell shape change, suggesting that Diaphanous helps coordinate ..
  62. pmc Local actin-dependent endocytosis is zygotically controlled to initiate Drosophila cellularization
    Anna Marie Sokac
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Dev Cell 14:775-86. 2008
    ..We propose that developmentally regulated endocytosis can coordinate actin/PM remodeling to directly drive furrow dynamics during morphogenesis...
  63. pmc Pulsed contractions of an actin-myosin network drive apical constriction
    Adam C Martin
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 457:495-9. 2009
    ..thought to be driven by the continuous purse-string-like contraction of a circumferential actin and non-muscle myosin-II (myosin) belt underlying adherens junctions...
  64. pmc Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia
    Stephen J Warner
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    J Cell Biol 185:1111-25. 2009
    ..In contrast, depletion of Rho1 in single cells decreases apical tension, and Rok and myosin are necessary, while Dia function also contributes, downstream of Rho1 to sustain apical cell tension.
  65. pmc The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction
    Jessica K Sawyer
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 186:57-73. 2009
    ..Instead, Cno localizes to AJs by a Rap1- and actin-dependent mechanism. These data suggest that Cno regulates linkage between AJs and the actin cytoskeleton during morphogenesis...
  66. doi Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary
    Katharina P Landsberg
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Biol 19:1950-5. 2009
    ..Cell bond tension is decreased in the presence of Y-27632 [7], an inhibitor of Rho-kinase whose main effector is Myosin II [8]. Simulations using a vertex model [9] demonstrate that a 2...
  67. pmc An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos
    Bruno Monier
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Nat Cell Biol 12:60-5; sup pp 1-9. 2010
    ..When MyoII (non-muscle myosin II) function is inhibited, including locally at the cable by chromophore-assisted laser inactivation (CALI), in ..
  68. doi Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing
    Seung Hee Baek
    Department of Biology, Yonsei University, 262 Seongsanno, Seodaemun gu, Seoul 120 749, Republic of Korea
    Biochem Biophys Res Commun 394:488-92. 2010
    A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis...
  69. pmc Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium
    Robert P Simone
    University of Pennsylvania Medical School, Department of Cell and Developmental Biology, 421 Curie Boulevard, Philadelphia, PA 19104 6048, USA
    Development 137:1385-94. 2010
    ..Additionally, we show that non-muscle Myosin II and the polarity proteins Discs large (Dlg) and Bazooka are enriched along cell interfaces in a complex but ..
  70. pmc The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia
    Stephen J Warner
    Department of Medicine, BRIGHT Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 20:677-86. 2010
    ..We considered whether disruption of the various polarity complexes could provide signals identifying damaged epithelial cells and thus lead to apoptosis-induced compensatory proliferation...
  71. doi The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila
    Daryl J V David
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Development 137:1645-55. 2010
    ..We have analyzed the relationship between myosin and the polarity regulators Par-6, aPKC and Bazooka (Par-3) (the PAR complex) during amnioserosa apical ..
  72. pmc Determinants of myosin II cortical localization during cytokinesis
    Ryota Uehara
    Physiology Course, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
    Curr Biol 20:1080-5. 2010
    ..accumulation at three different stages: (1) turnover of thick filaments throughout the cell cycle, (2) myosin heavy chain-based control of myosin assembly at the metaphase-anaphase transition, and (3) redistribution and/or ..
  73. pmc Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis
    Josef D Franke
    Department of Biology, Duke University, Durham, NC 27708, USA
    Dev Biol 345:117-32. 2010
    Metazoan development involves a myriad of dynamic cellular processes that require cytoskeletal function. Nonmuscle myosin II plays essential roles in embryonic development; however, knowledge of its role in post-embryonic development, ..
  74. pmc Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation
    Sérgio de Matos Simões
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 19:377-88. 2010
    ..We show that Bazooka/Par-3 (Baz) is required for the planar polarized distribution of myosin II and adherens junction proteins and polarized intercalary behavior is disrupted in baz mutants...
  75. pmc Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure
    Caroline Laplante
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Cell Biol 192:335-48. 2011
    ..The planar polarized distribution of Ed in the DME cells thus provides a spatial cue that polarizes the DME cell actin cytoskeleton, defining the epidermal leading edge and establishing its contractile properties...
  76. pmc Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling
    Y Jiang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 30:3248-60. 2011
    ..Mechanistically, we show that sds22 prevents cell invasion and metastasis by inhibiting myosin II and Jun N-terminal kinase (JNK) activity downstream of PP1...
  77. pmc Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration
    Pralay Majumder
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Biol 22:363-72. 2012
    ..of Drosophila border cells, a genetically tractable model for collective cell migration, requires nonmuscle myosin-II (Myo-II)...
  78. doi Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction
    Daryl J V David
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Development 140:4719-29. 2013
    ..This later impact of aPKC inhibition is supported by mathematical modelling of the system. Overall, this work illustrates how shifting chemical signals can tune actomyosin network behaviour during development...
  79. pmc Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation
    Bing He
    1 Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA 2
    Nature 508:392-6. 2014
    ....
  80. ncbi Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
    C G Winter
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 105:81-91. 2001
    ..is regulating the phosphorylation of nonmuscle myosin regulatory light chain, and hence the activity of myosin II. Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with ..
  81. ncbi Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
    D L Silver
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 107:831-41. 2001
    ..Ectopic expression of either UPD or JAK is sufficient to induce extra epithelial cells to migrate. Thus, a localized signal activates the JAK/STAT pathway in neighboring epithelial cells, causing them to become invasive...
  82. ncbi Segment boundary formation in Drosophila embryos
    Camilla W Larsen
    National Institute for Medical Research, The Ridgeway Mill Hill, London NW7 1AA, UK
    Development 130:5625-35. 2003
    ..In addition, Wingless signalling at the anterior of the domains of engrailed (and hedgehog) expression represses groove formation and thus ensures that segment boundaries form only at the posterior...
  83. pmc Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis
    Cynthia A Bayer
    Department of Biology, University of Central Florida, Orlando, Florida 32816 2368, USA
    Genetics 165:1417-32. 2003
    ..RhoA enhance leg and wing defects associated with mutations in zipper, the gene encoding the heavy chain of nonmuscle myosin II. We demonstrate here that mutations affecting the RhoA signaling pathway also interact genetically with ..
  84. doi Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site
    Pier Paolo D'Avino
    Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
    J Cell Sci 121:1151-8. 2008
    Anillin, one of the first factors recruited to the cleavage site during cytokinesis, interacts with actin, myosin II and septins, and is essential for proper organization of the actomyosin contractile ring...
  85. ncbi hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
    B Glise
    Centre de Biologie du Developpement, Centre National de la Recherche Scientifique, Toulouse, France
    Cell 83:451-61. 1995
    ..These data suggest that hep functions in a novel Drosophila MAPK pathway, controlling puckered expression and morphogenetic activity of the dorsal epidermis...
  86. doi DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment
    Astrid G Petzoldt
    Institute of Biology Valrose, University of Nice Sophia Antipolis, UMR7277 CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France
    Development 139:1874-84. 2012
    ..Recent work in Drosophila has identified a novel situs inversus gene encoding the unconventional type ID myosin (MyoID)...
  87. ncbi Drosophila morphogenesis: movements behind the edge
    E Knust
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatstrasse 1, 40225 Dusseldorf, Germany
    Curr Biol 7:R558-61. 1997
    ..Coordinated cell movements during development require extensive exchange of information between the cells involved. Recent results suggest a connection between two signalling pathways during dorsal closure in the Drosophila embryo...
  88. ncbi High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation rates
    C Schlotterer
    Institut fur Tierzucht und Genetik, Vienna, Austria
    Mol Biol Evol 15:1269-74. 1998
    ..The allele-specific mutation rate of 3.0 x 10(-4) per generation is within the range of mammalian mutation rates. Future microsatellite analyses will have to account for the dramatic differences in allele-specific mutation rates...
  89. ncbi ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton
    K J Blake
    Department of Anatomy, MC 3405, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Dev Genes Evol 209:555-9. 1999
    ..Mutations of zip, which encodes the nonmuscle myosin heavy chain, suppress the phenotypes of rib and raw, suggesting that rib and raw are not directly required for ..
  90. ncbi A targeted gene silencing technique shows that Drosophila myosin VI is required for egg chamber and imaginal disc morphogenesis
    W Deng
    Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Edinburgh EH9 3JR, UK
    J Cell Sci 112:3677-90. 1999
    We report that Drosophila unconventional myosin VI, encoded by Myosin heavy chain at 95F (Mhc95F), is required for both imaginal disc and egg chamber morphogenesis...
  91. ncbi Microtubules and mitotic cycle phase modulate spatiotemporal distributions of F-actin and myosin II in Drosophila syncytial blastoderm embryos
    V E Foe
    Department of Zoology, University of Washington, Seattle WA 98195 1800, USA
    Development 127:1767-87. 2000
    ..They provide evidence that filamentous actin and cytoplasmic myosin II are transported along microtubules towards microtubule plus ends, with actin and myosin exhibiting ..
  92. ncbi Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies
    Z Su
    Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University Medical Center, and University Programs in Genetics and Cellular and Molecular Biology, Durham, North Carolina 27710, USA
    Biochemistry 40:3606-14. 2001
    ..Thus, the nonmuscle myosin heavy chain in Drosophila, which is encoded by the zipper gene, appears to be similar to rabbit nonmuscle myosin-..
  93. ncbi Posterior midgut epithelial cells differ in their organization of the membrane skeleton from other drosophila epithelia
    O Baumann
    Institut für Biochemie und Biologie, Universitat Potsdam, Potsdam, 14471, Germany
    Exp Cell Res 270:176-87. 2001
    ..Finally, despite the absence of zonulae adherentes, F-actin, beta(H)-spectrin, and nonmuscle myosin-II are enriched in the midlateral region...
  94. ncbi A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis
    W Gregory Somers
    Centre for the Molecular Genetics of Development, Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
    Dev Cell 4:29-39. 2003
    ....
  95. pmc Nonmuscle myosin promotes cytoplasmic localization of PBX
    He Huang
    McGill Cancer Centre, Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 23:3636-45. 2003
    ..additional proteins directing PBX subcellular localization, we identified a fragment of murine nonmuscle myosin II heavy chain B (NMHCB)...
  96. ncbi Myosins motor Miranda
    Daniel P Kiehart
    Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, Durham, NC 27708, USA
    Mol Cell 12:1346-7. 2003
    New evidence shows that myosin motors drive the spatial segregation of cell fate determinants during asymmetric cell division. How they do so remains a mystery.
  97. pmc Anillin binds nonmuscle myosin II and regulates the contractile ring
    Aaron F Straight
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 16:193-201. 2005
    We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation...
  98. ncbi The centrosomal protein CP190 regulates myosin function during early Drosophila development
    S Chodagam
    The Gurdon Institute, Department of Genetics, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    Curr Biol 15:1308-13. 2005
    Centrosomes are the main microtubule (MT)-organizing centers in animal cells, but they also influence the actin/myosin cytoskeleton...
  99. pmc Rho-kinase controls cell shape changes during cytokinesis
    Gilles R X Hickson
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Curr Biol 16:359-70. 2006
    ..To explore the initiation of cytokinesis, we focused on the earliest cell shape change, cell elongation, which occurs during anaphase B and prior to cytokinetic furrowing...
  100. pmc Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis
    Muriel Grammont
    Institut National de la Sante et de la Recherche Medicale, Unité 384, Clermont Ferrand F 63001, France
    J Cell Biol 177:139-50. 2007
    ..This results in abnormal StC flattening and delayed MBFC displacement. Additionally, accumulation of the myosin II heavy chain Zipper is delayed at the AJs that require disassembly...

Research Grants1

  1. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2005
    ..abstract_text> ..