15 hydroxyprostaglandin dehydrogenase

Summary

Gene Symbol: 15 hydroxyprostaglandin dehydrogenase
Description: 15-hydroxyprostaglandin dehydrogenase
Alias: 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-hydroxyprostaglandin dehydrogenase (NAD(+)), NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, hydroxyprostaglandin dehydrogenase 15-(NAD), prostaglandin dehydrogenase 1, short chain dehydrogenase/reductase family 36C member 1
Species: human

Top Publications

  1. Huang G, Eisenberg R, Yan M, Monti S, Lawrence E, Fu P, et al. 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. Cancer Res. 2008;68:5040-8 pubmed publisher
    ..In a transcriptional profiling study using a conditional cell line system, we now identify 15-PGDH as one of the major genes induced by HNF3beta expression...
  2. Yan M, Rerko R, Platzer P, Dawson D, Willis J, Tong M, et al. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A. 2004;101:17468-73 pubmed
    ..prostaglandin biogenesis pathway by ubiquitously abrogating expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that physiologically antagonizes COX-2...
  3. Myung S, Rerko R, Yan M, Platzer P, Guda K, Dotson A, et al. 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci U S A. 2006;103:12098-102 pubmed
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers...
  4. Cho H, Hamza A, Zhan C, Tai H. Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch Biochem Biophys. 2005;433:447-53 pubmed
    NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a member of the short-chain dehydrogenase/reductase (SDR) family, catalyzes the first step in the catabolic pathways of prostaglandins and lipoxins, and is believed to be ..
  5. Backlund M, Mann J, Holla V, Shi Q, Daikoku T, Dey S, et al. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res. 2008;68:9331-7 pubmed publisher
    ..Enzymatic degradation of PGE(2) involves the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Recent reports have shown a marked diminution of 15-PGDH expression in colorectal carcinomas (CRC)...
  6. Hoeft B, Linseisen J, Beckmann L, Muller Decker K, Canzian F, Husing A, et al. Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk. Carcinogenesis. 2010;31:466-72 pubmed publisher
    ..Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk. ..
  7. Poole E, Hsu L, Xiao L, Kulmacz R, Carlson C, Rabinovitch P, et al. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2010;19:547-57 pubmed publisher
    ..candidate and tagSNPs in PGE2 synthase (PGES), PGE2 receptors (EP2 and EP4), and prostaglandin dehydrogenase (PGDH) in a case-control study of adenomas (n = 483) versus polyp-free controls (n = 582) and examined interactions with ..
  8. Sun Q, Chen Z, He P, Li Y, Ding X, Huang Y, et al. Reduced Expression of Hydrogen Sulfide-Generating Enzymes Down-Regulates 15-Hydroxyprostaglandin Dehydrogenase in Chorion during Term and Preterm Labor. Am J Pathol. 2018;188:63-71 pubmed publisher
    Chorionic NAD-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) plays a pivotal role in controlling the amount of prostaglandins in the uterus and has been implicated in the process of labor...
  9. Hughes D, Otani T, Yang P, Newman R, Yantiss R, Altorki N, et al. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. Cancer Prev Res (Phila). 2008;1:241-9 pubmed publisher
    ..NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for metabolic inactivation of PGs, is down-regulated in various malignancies...
  10. Tariq M, Azeem Z, Ali G, Chishti M, Ahmad W. Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC). J Med Genet. 2009;46:14-20 pubmed publisher
    ..S193P) in exon 6 of the human HPGD gene encoding NAD(+) dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH)...

Detail Information

Publications62

  1. Huang G, Eisenberg R, Yan M, Monti S, Lawrence E, Fu P, et al. 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. Cancer Res. 2008;68:5040-8 pubmed publisher
    ..In a transcriptional profiling study using a conditional cell line system, we now identify 15-PGDH as one of the major genes induced by HNF3beta expression...
  2. Yan M, Rerko R, Platzer P, Dawson D, Willis J, Tong M, et al. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A. 2004;101:17468-73 pubmed
    ..prostaglandin biogenesis pathway by ubiquitously abrogating expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that physiologically antagonizes COX-2...
  3. Myung S, Rerko R, Yan M, Platzer P, Guda K, Dotson A, et al. 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci U S A. 2006;103:12098-102 pubmed
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers...
  4. Cho H, Hamza A, Zhan C, Tai H. Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch Biochem Biophys. 2005;433:447-53 pubmed
    NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a member of the short-chain dehydrogenase/reductase (SDR) family, catalyzes the first step in the catabolic pathways of prostaglandins and lipoxins, and is believed to be ..
  5. Backlund M, Mann J, Holla V, Shi Q, Daikoku T, Dey S, et al. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res. 2008;68:9331-7 pubmed publisher
    ..Enzymatic degradation of PGE(2) involves the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Recent reports have shown a marked diminution of 15-PGDH expression in colorectal carcinomas (CRC)...
  6. Hoeft B, Linseisen J, Beckmann L, Muller Decker K, Canzian F, Husing A, et al. Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk. Carcinogenesis. 2010;31:466-72 pubmed publisher
    ..Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk. ..
  7. Poole E, Hsu L, Xiao L, Kulmacz R, Carlson C, Rabinovitch P, et al. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2010;19:547-57 pubmed publisher
    ..candidate and tagSNPs in PGE2 synthase (PGES), PGE2 receptors (EP2 and EP4), and prostaglandin dehydrogenase (PGDH) in a case-control study of adenomas (n = 483) versus polyp-free controls (n = 582) and examined interactions with ..
  8. Sun Q, Chen Z, He P, Li Y, Ding X, Huang Y, et al. Reduced Expression of Hydrogen Sulfide-Generating Enzymes Down-Regulates 15-Hydroxyprostaglandin Dehydrogenase in Chorion during Term and Preterm Labor. Am J Pathol. 2018;188:63-71 pubmed publisher
    Chorionic NAD-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) plays a pivotal role in controlling the amount of prostaglandins in the uterus and has been implicated in the process of labor...
  9. Hughes D, Otani T, Yang P, Newman R, Yantiss R, Altorki N, et al. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. Cancer Prev Res (Phila). 2008;1:241-9 pubmed publisher
    ..NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for metabolic inactivation of PGs, is down-regulated in various malignancies...
  10. Tariq M, Azeem Z, Ali G, Chishti M, Ahmad W. Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC). J Med Genet. 2009;46:14-20 pubmed publisher
    ..S193P) in exon 6 of the human HPGD gene encoding NAD(+) dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH)...
  11. Cronin S, Tomik B, Bradley D, Slowik A, Hardiman O. Screening for replication of genome-wide SNP associations in sporadic ALS. Eur J Hum Genet. 2009;17:213-8 pubmed publisher
    ..The result for DPP6 is surprising, as it has been replicated elsewhere. We discuss the possible interpretations and implications of these findings for future ALS GWA studies both within and between populations. ..
  12. Tong M, Tai H. 15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells. Arch Biochem Biophys. 2005;435:50-5 pubmed
    Dexamethasone induced the expression of 15-PGDH in a time- and concentration-dependent manner in A549 human lung adenocarcinoma cells. Maximal induction was observed at 10nM...
  13. Castro Sanchez L, Agra N, Llorente Izquierdo C, Motiño O, Casado M, Bosca L, et al. Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. Int J Biochem Cell Biol. 2013;45:2501-11 pubmed publisher
    ..pathways involving nicotinamide adenine dinucleotide (NAD(+))-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH is a crucial enzyme responsible for the biological inactivation of PGE2...
  14. Bou Saab J, Bacchetta M, Chanson M. Ineffective correction of PPARγ signaling in cystic fibrosis airway epithelial cells undergoing repair. Int J Biochem Cell Biol. 2016;78:361-369 pubmed publisher
    ..The HPGD/PPARγ axis is deregulated in primary HAEC cultures from CF patients, which may impact the maturation of BCs to differentiated luminal cells. Importantly, PPARγ therapy was inefficient in correcting the CF defect. ..
  15. El Hattab A, Shaheen R, Hertecant J, Galadari H, Albaqawi B, Nabil A, et al. On the phenotypic spectrum of serine biosynthesis defects. J Inherit Metab Dis. 2016;39:373-81 pubmed publisher
    L-serine is a non-essential amino acid that is de novo synthesized via the enzymes phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP)...
  16. Kishore A, Owens D, Word R. Prostaglandin E2 regulates its own inactivating enzyme, 15-PGDH, by EP2 receptor-mediated cervical cell-specific mechanisms. J Clin Endocrinol Metab. 2014;99:1006-18 pubmed publisher
    ..Prior to cervical ripening at term, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is highly expressed in the cervix and metabolizes cyclooxygenase-2-mediated increases in active prostaglandin E2 (..
  17. Sangha R, Walton J, Ensor C, Tai H, Challis J. Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor. J Clin Endocrinol Metab. 1994;78:982-9 pubmed
    Type 1 15-hydroxyprostaglandin dehydrogenase (PGDH) is the main enzyme responsible for the metabolism of prostaglandin E2 (PGE2) and PGF2 alpha...
  18. McKeown K, Challis J. Regulation of 15-hydroxy prostaglandin dehydrogenase by corticotrophin-releasing hormone through a calcium-dependent pathway in human chorion trophoblast cells. J Clin Endocrinol Metab. 2003;88:1737-41 pubmed
    ..events, and their synthesis and metabolism are regulated by PG H synthase and 15-hydroxy-PG dehydrogenase (PGDH), respectively. Within the chorion tissue, it is the actions of PGDH that predominate...
  19. Nandy A, Jenatschke S, Hartung B, Milde Langosch K, Bamberger A, Gellersen B. Genomic structure and transcriptional regulation of the human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene. J Mol Endocrinol. 2003;31:105-21 pubmed
    The NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is a catabolic enzyme that controls the biological activities of prostaglandins by converting them into inactive keto-metabolites...
  20. Qi X, Wang Y, Hou J, Huang Y. A Single Nucleotide Polymorphism in HPGD Gene Is Associated with Prostate Cancer Risk. J Cancer. 2017;8:4083-4086 pubmed publisher
    ..767, p = 0.019). Conclusions: rs8752 in the 3'untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene was found to be responsible for the susceptibility to prostate cancer in Chinese individuals...
  21. Tsuruta K, Mori N. Pulmonary and placental 15-hydroxyprostaglandin dehydrogenase in rat during pregnancy. Eur J Obstet Gynecol Reprod Biol. 1988;27:71-9 pubmed
    15-Hydroxyprostaglandin dehydrogenase (PGDH) in rat lung and placenta during pregnancy was examined using a photometric assay...
  22. Niesen F, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney D, et al. High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS ONE. 2010;5:e13719 pubmed publisher
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation...
  23. Lim S, Cho H, Lee T, Choi C, Min Y, Kim S, et al. Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer. Yonsei Med J. 2010;51:692-9 pubmed publisher
    ..phospholipase A2 (cPLA2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH) have been suggested to be related to carcinogenesis of colorectal cancer (CRC)...
  24. Arima K, Komohara Y, Bu L, Tsukamoto M, Itoyama R, Miyake K, et al. Down-regulation of 15-PGDH by interleukin-1 beta from activated macrophages leads to poor prognosis in pancreatic cancer. Cancer Sci. 2017;: pubmed publisher
    ..The enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) degrades prostaglandin and is frequently decreased in several types of cancer; however, the molecular mechanisms ..
  25. Greenland K, Jantke I, Jenatschke S, Bracken K, Vinson C, Gellersen B. The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone. Endocrinology. 2000;141:581-97 pubmed
    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is a key catabolic enzyme in the inactivation of PGF2alpha and PGE2 and therefore serves as an important determinant in regulating their local concentrations...
  26. Lin J, Zhong J. Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol. Bioprocess Biosyst Eng. 2017;40:1133-1139 pubmed publisher
    ..Among these proteins, D-3-phosphoglycerate dehydrogenase (PGDH) and glyceraldehyde 3-phosphate dehydrogenase showed statistically significant up-regulation in ammonium vs...
  27. Nakanishi T, Tamai I. Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins. AAPS J. 2017;20:13 pubmed publisher
    ..Here, we review and summarize recent information on the molecular functions of OATP2A1 and on its physiological and pathological significance...
  28. Grant G. Regulatory Mechanism of Mycobacterium tuberculosis Phosphoserine Phosphatase SerB2. Biochemistry. 2017;: pubmed publisher
    ..Many organisms control the activity of the first enzyme in the pathway, d-3-phosphoglycerate dehydrogenase (PGDH), by feedback inhibition through the interaction of l-serine with the ACT domains within the enzyme...
  29. Hou Y, Lin Y, Qi X, Yuan L, Liao R, Pang Q, et al. Identification of mutations in the prostaglandin transporter gene SLCO2A1 and phenotypic comparison between two subtypes of primary hypertrophic osteoarthropathy (PHO): A single-center study. Bone. 2018;106:96-102 pubmed publisher
    ..SLCO2A1), PHO is categorized into two subtypes: hypertrophic osteoarthropathy, primary, autosomal recessive 1 (PHOAR1) and hypertrophic osteoarthropathy, primary, autosomal recessive 2 (PHOAR2)...
  30. Seta V, Capri Y, Battistella M, Bagot M, Bourrat E. Pachydermoperiostosis: The value of molecular diagnosis. Ann Dermatol Venereol. 2017;144:799-803 pubmed publisher
    ..Given the genotype/phenotype correlations illustrated by these cases, it would appear useful to propose molecular diagnosis for patients presenting pachydermoperiostosis. ..
  31. Gascoyne D, Lyne L, Spearman H, Buffa F, Soilleux E, Banham A. Vitamin D Receptor Expression in Plasmablastic Lymphoma and Myeloma Cells Confers Susceptibility to Vitamin D. Endocrinology. 2017;158:503-515 pubmed publisher
    ..In summary, HLY-1 provides an important model of strongly plasmablastic lymphoma, and disruption of VDR pathway activity may be of therapeutic benefit in both plasmablastic lymphoma and myeloma...
  32. Seifert W, Beninde J, Hoffmann K, Lindner T, Bassir C, Aksu F, et al. HPGD mutations cause cranioosteoarthropathy but not autosomal dominant digital clubbing. Eur J Hum Genet. 2009;17:1570-6 pubmed publisher
    ..The failure to identify any mutation in a family with an autosomal dominant type of isolated digital clubbing suggests that HPGD is not the major gene for this condition...
  33. Judson B, Miyaki A, Kekatpure V, Du B, Gilleaudeau P, Sullivan Whalen M, et al. UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression. Cancer Prev Res (Phila). 2010;3:1104-11 pubmed publisher
    ..15-Hydroxyprostaglandin deyhdrogenase (15-PGDH), a tumor suppressor gene, plays a major role in PG catabolism...
  34. Quidville V, Segond N, Lausson S, Frenkian M, Cohen R, Jullienne A. 15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line. Prostaglandins Other Lipid Mediat. 2006;81:14-30 pubmed
    ..in vivo and in vitro, decreases proliferation and increases activity of 15-hydroxyprostaglandin-dehydrogenase (15-PGDH), the PG catabolism key enzyme...
  35. Cong R, Tao K, Fu P, Lou L, Zhu Y, Chen S, et al. MicroRNA‑218 promotes prostaglandin E2 to inhibit osteogenic differentiation in synovial mesenchymal stem cells by targeting 15‑hydroxyprostaglandin dehydrogenase [NAD(+)]. Mol Med Rep. 2017;16:9347-9354 pubmed publisher
    ..The results of the present study provided a novel insight beneficial to cellular manipulation methods during cartilage regeneration, and in cartilage tissue engineering research...
  36. Liu Z, Wang X, Lu Y, Han S, Zhang F, Zhai H, et al. Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. Carcinogenesis. 2008;29:1219-27 pubmed publisher
    ..15-Hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH), a key enzyme in prostaglandin degradation, was identified as an upregulated protein in SGC7901 cells transfected ..