AADAC

Summary

Gene Symbol: AADAC
Description: arylacetamide deacetylase
Alias: CES5A1, DAC, arylacetamide deacetylase, arylacetamide deacetylase (esterase)
Species: human
Products:     AADAC

Top Publications

  1. Wu D, Zhang Y, Zhao Y, Guo J, Chang C. [Inhibitory Effect of Decitabine on Proliferation of MDS-L Cells and Its Mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1471-1476 pubmed publisher
    To investigate the inhibitory effect of decitabine (DAC) in various dosages on the proliferention of MDS-RAEB cell line MDS-L and its mechanism.
  2. Ramakrishnan S, Hu Q, Krishnan N, Wang D, Smit E, Granger V, et al. Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer. Cell Death Dis. 2017;8:3217 pubmed publisher
    ..DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor genes, alter immune response and epigenetically ..
  3. Toeri J, Osorio Madrazo A, Laborie M. Preparation and Chemical/Microstructural Characterization of Azacrown Ether-Crosslinked Chitosan Films. Materials (Basel). 2017;10: pubmed publisher
    ..crosslink bridges were produced between the amine groups of chitosan (Ch) and the allyl groups of the azacrown (DAC)...
  4. Ueda K, Masuda A, Fukuda M, Tanaka S, Hosokawa M, Iwakawa S. Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells. Drug Metab Pharmacokinet. 2017;: pubmed publisher
    Decitabine (DAC), a nucleoside-related DNA methylation inhibitor, is taken up into cancer cells via equilibrative nucleoside transporter 1 (ENT1), and is then monophosphorylated by deoxycytidine kinase (dCK)...
  5. Mziaut H, Korza G, Hand A, Gerard C, Ozols J. Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. J Biol Chem. 1999;274:14122-9 pubmed
    ....
  6. Freed A, Wang Y, McCulloch S, Myers T, Suzuki R. Mucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction. J Appl Physiol (1985). 1999;87:1724-33 pubmed
    ..We found that epithelial cells increased in BALF immediately after a 2- and a 5-min dry air challenge (DAC)...
  7. Tang Z, Cao W, Guo X, Dai X, Lu J, Chen X, et al. Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer. Cancer Lett. 2018;412:1-9 pubmed publisher
    ..Furthermore, we found for the first time that dacomitinib (DAC), a second-generation epidermal growth factor receptor inhibitor that in the phase III clinical trials for NSCLC ..
  8. Cui J, Xiao Y, You Y, Shi W, Li Q, Luo Y, et al. Decitabine for relapsed acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation. J Huazhong Univ Sci Technolog Med Sci. 2017;37:693-698 pubmed publisher
    ..Our study assessed the efficacy of decitabine (DAC) for treating patients with acute lymphoblastic leukemia (ALL) who relapsed after allogeneic hematopoietic stem ..
  9. Schroeder T, Rautenberg C, Haas R, Germing U, Kobbe G. Hypomethylating agents for treatment and prevention of relapse after allogeneic blood stem cell transplantation. Int J Hematol. 2017;: pubmed publisher
    ..Given this unmet medical need the hypomethylating agents (HMA), Azacitidine (Aza) and Decitabine (DAC) have been tested as salvage therapy in patients with myeloid malignancies relapsing after allo-SCT...
  10. Nourbakhsh M, Douglas D, Pu C, Lewis J, Kawahara T, Lisboa L, et al. Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production. J Hepatol. 2013;59:336-43 pubmed publisher
    ..This was partially explained by an apparent deficiency of a putative TG lipase, arylacetamide deacetylase (AADAC)...

Detail Information

Publications62

  1. Wu D, Zhang Y, Zhao Y, Guo J, Chang C. [Inhibitory Effect of Decitabine on Proliferation of MDS-L Cells and Its Mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1471-1476 pubmed publisher
    To investigate the inhibitory effect of decitabine (DAC) in various dosages on the proliferention of MDS-RAEB cell line MDS-L and its mechanism.
  2. Ramakrishnan S, Hu Q, Krishnan N, Wang D, Smit E, Granger V, et al. Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer. Cell Death Dis. 2017;8:3217 pubmed publisher
    ..DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor genes, alter immune response and epigenetically ..
  3. Toeri J, Osorio Madrazo A, Laborie M. Preparation and Chemical/Microstructural Characterization of Azacrown Ether-Crosslinked Chitosan Films. Materials (Basel). 2017;10: pubmed publisher
    ..crosslink bridges were produced between the amine groups of chitosan (Ch) and the allyl groups of the azacrown (DAC)...
  4. Ueda K, Masuda A, Fukuda M, Tanaka S, Hosokawa M, Iwakawa S. Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells. Drug Metab Pharmacokinet. 2017;: pubmed publisher
    Decitabine (DAC), a nucleoside-related DNA methylation inhibitor, is taken up into cancer cells via equilibrative nucleoside transporter 1 (ENT1), and is then monophosphorylated by deoxycytidine kinase (dCK)...
  5. Mziaut H, Korza G, Hand A, Gerard C, Ozols J. Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. J Biol Chem. 1999;274:14122-9 pubmed
    ....
  6. Freed A, Wang Y, McCulloch S, Myers T, Suzuki R. Mucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction. J Appl Physiol (1985). 1999;87:1724-33 pubmed
    ..We found that epithelial cells increased in BALF immediately after a 2- and a 5-min dry air challenge (DAC)...
  7. Tang Z, Cao W, Guo X, Dai X, Lu J, Chen X, et al. Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer. Cancer Lett. 2018;412:1-9 pubmed publisher
    ..Furthermore, we found for the first time that dacomitinib (DAC), a second-generation epidermal growth factor receptor inhibitor that in the phase III clinical trials for NSCLC ..
  8. Cui J, Xiao Y, You Y, Shi W, Li Q, Luo Y, et al. Decitabine for relapsed acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation. J Huazhong Univ Sci Technolog Med Sci. 2017;37:693-698 pubmed publisher
    ..Our study assessed the efficacy of decitabine (DAC) for treating patients with acute lymphoblastic leukemia (ALL) who relapsed after allogeneic hematopoietic stem ..
  9. Schroeder T, Rautenberg C, Haas R, Germing U, Kobbe G. Hypomethylating agents for treatment and prevention of relapse after allogeneic blood stem cell transplantation. Int J Hematol. 2017;: pubmed publisher
    ..Given this unmet medical need the hypomethylating agents (HMA), Azacitidine (Aza) and Decitabine (DAC) have been tested as salvage therapy in patients with myeloid malignancies relapsing after allo-SCT...
  10. Nourbakhsh M, Douglas D, Pu C, Lewis J, Kawahara T, Lisboa L, et al. Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production. J Hepatol. 2013;59:336-43 pubmed publisher
    ..This was partially explained by an apparent deficiency of a putative TG lipase, arylacetamide deacetylase (AADAC)...
  11. Zhang Y, Mei Q, Liu Y, Li X, Brock M, Chen M, et al. The safety, efficacy, and treatment outcomes of a combination of low-dose decitabine treatment in patients with recurrent ovarian cancer. Oncoimmunology. 2017;6:e1323619 pubmed publisher
    ..Clinical benefits could be associated with the number of DAC treatment cycles and the inclusion of CIK immunotherapy. In DTC+CIK cohort, DCR and ORR reached 100% and 58...
  12. Shaw Z, Feilner W, Esser B, Dickens J, Neuber A. A software controllable modular RF signal generator with multichannel transmission capabilities. Rev Sci Instrum. 2017;88:094706 pubmed publisher
    ..Each channel is comprised of a data pattern generator (DPG), a digital to analog converter (DAC), a power amplifier, and a transmitting antenna...
  13. Abbo B, Hulslander L, Goldade D. Determination of 20, 25-diazacholesterol in avian matrices by high performance liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1065-1066:129-133 pubmed publisher
    ..One promising avian contraceptive compound, 20,25-diazacholesterol (DAC), reduces fertility by inhibiting cholesterol synthesis...
  14. Xiao Z, Zhuge Q, Fu S, Zhang F, Qiu M, Tang M, et al. Low complexity split digital backpropagation for digital subcarrier-multiplexing optical transmissions. Opt Express. 2017;25:27824-27833 pubmed publisher
    ..We also numerically investigate the impact of the digital-to-analog converter (DAC) resolution and fiber parameter uncertainties on the nonlinear compensation performance of the SSDBP.
  15. Tarasevicius S, Robertsson O, Dobozinskas P, Wingstrand H. A comparison of outcomes and dislocation rates using dual articulation cups and THA for intracapsular femoral neck fractures. Hip Int. 2013;23:22-6 pubmed publisher
    ..The aim of our study was to investigate FNF patients treated with dual articulation cups (DAC) and conventional THA and compare their clinical results at four months and one year after surgery...
  16. Schroeder T, Rautenberg C, Krüger W, Platzbecker U, Bug G, Steinmann J, et al. Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI-a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group. Ann Hematol. 2018;97:335-342 pubmed publisher
    ..to the evidence regarding azacitidine (Aza), there is limited knowledge about the combination of decitabine (DAC) and donor lymphocyte infusions as salvage therapy for relapse after allogeneic stem cell transplantation (allo-SCT)..
  17. Ferreira R, Pan Hammarstrom Q, Graham R, Gateva V, Fontan G, Lee A, et al. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nat Genet. 2010;42:777-80 pubmed publisher
    ..0 x 10(-4)) or random SNPs across the genome (P < 0.0001). These findings support the hypothesis that autoimmune mechanisms may contribute to the pathogenesis of IgAD. ..
  18. Freed A, Taskar V, Schofield B, Omori C. Hyperventilation-induced airway injury and vascular leakage in dogs: effects of alpha1-adrenergic agonists. J Appl Physiol (1985). 1997;83:1884-9 pubmed
    ..methoxamine (Mx), norepinephrine (NE), or saline aerosol; and then exposed to a 2,000 ml/min dry-air challenge (DAC) for 2 min. Colloidal carbon was injected before DAC and used to quantify bronchovascular permeability...
  19. Pan J, McLaughlin J, Yang H, Leo C, Rambarat P, Okuwa S, et al. Comparative analysis of behavioral and transcriptional variation underlying CO2 sensory neuron function and development in Drosophila. Fly (Austin). 2017;11:239-252 pubmed publisher
    ..in the expression of a few genes known to be involved in the development of the CO2 circuit, namely dac, an important regulator of sensilla fate for sensilla that house CO2 ORNs, and mip120, a member of the ..
  20. Xie T, Huang C, Kang X, Luo J, Qin X, Han F. A Network Meta-Analysis of Short and Long-Term Efficacy of Targeted Therapy With Single or Double-Drug Regimens in the Treatment of Stage III/IV Malignant Melanoma Based on 16 Randomized Controlled Trials. J Cell Biochem. 2018;119:640-649 pubmed publisher
    ..regimens (Vemurafenib [Vem], Dabrafenib [Dab], and Nivolumab [Niv]) were higher than those of Dacarbazine (Dac)...
  21. Simon M, Murchison C, Iliff J. A transcriptome-based assessment of the astrocytic dystrophin-associated complex in the developing human brain. J Neurosci Res. 2018;96:180-193 pubmed publisher
    ..stages and brain regions to characterize the gene expression profile of the dystrophin-associated complex (DAC), a known structural component of the astrocytic endfoot that supports perivascular localization of the astroglial ..
  22. Wu X, Hu Z, Nizzero S, Zhang G, Ramirez M, Shi C, et al. Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity. J Control Release. 2017;268:92-101 pubmed publisher
    ..Recent clinical studies on combination therapy of decitabine (DAC) and arsenic trioxide (ATO) have demonstrated synergy on MDS treatment, but the treatment can cause significant ..
  23. Li W, Wang Y, Chen S, Qiu H, Fu Z, Wu D, et al. Consolidation therapy with decitabine and intermediate-dose cytarabine followed by HLA-mismatched peripheral blood stem cells infusion for older patients with acute myeloid leukemia in first remission. Leuk Lymphoma. 2017;:1-7 pubmed publisher
    This retrospective study tested the feasibility of decitabine (DAC) plus intermediate-dose cytarabine (ID-AraC) followed by HLA-mismatched granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral donor blood stem cells (GPBSCs) ..
  24. Li X, Zhong S, Morizio J. 16-Channel biphasic current-mode programmable charge balanced neural stimulation. Biomed Eng Online. 2017;16:104 pubmed publisher
    ..Each channel consists of a 7-bit controllable current DAC used as sink and source current driver...
  25. Hong C, Siddiqui A, Sabljic T, Ball A. Changes in parvalbumin immunoreactive retinal ganglion cells and amacrine cells after optic nerve injury. Exp Eye Res. 2016;145:363-372 pubmed publisher
    ..There was no change in PARV AC or dAC number or staining intensity...
  26. Yamazaki K, Kusano K, Tadano K, Tanaka I. Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3. Genomics. 1997;44:248-50 pubmed
  27. Zeng W, Dai H, Yan M, Cai X, Luo H, Ke M, et al. Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation. J Immunol Res. 2017;2017:4302320 pubmed publisher
    ..Currently, the recommended treatment for patients with high-risk MDS is the methylation agent decitabine (DAC), a drug that can induce the reexpression of silenced tumor suppressor genes...
  28. Nakajima A, Fukami T, Kobayashi Y, Watanabe A, Nakajima M, Yokoi T. Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine. Biochem Pharmacol. 2011;82:1747-56 pubmed publisher
    ..In this study, we found that recombinant human arylacetamide deacetylase (AADAC) could efficiently deacetylate rifamycins, whereas human carboxylesterases, which are enzymes ..
  29. Yoshida T, Fukami T, Kurokawa T, Gotoh S, Oda A, Nakajima M. Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans. Eur J Pharm Sci. 2018;111:167-176 pubmed publisher
    Carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the major enzymes responsible for the hydrolysis of various clinical drugs...
  30. Pan C, Liu L, Chen Q, Zhang Q, Guo G. Tough, Stretchable, Compressive Novel Polymer/Graphene Oxide Nanocomposite Hydrogels with Excellent Self-Healing Performance. ACS Appl Mater Interfaces. 2017;9:38052-38061 pubmed publisher
    ..GO) hydrogels by free-radical polymerization of acrylamide (AM) and 2-(dimethylamino)ethylacrylatemethochloride (DAC) in the presence of GO...
  31. Seipel A, Whitington T, Delahunt B, Samaratunga H, Mayrhofer M, Wiklund P, et al. Genetic Profile of Ductal Adenocarcinoma of the Prostate. Hum Pathol. 2017;: pubmed publisher
    ..almost 50years ago little is known regarding the genetic profile of ductal adenocarcinoma of the prostate (DAC)...
  32. Ragon B, Daver N, Garcia Manero G, Ravandi F, Cortes J, Kadia T, et al. Minimal residual disease eradication with epigenetic therapy in core binding factor acute myeloid leukemia. Am J Hematol. 2017;92:845-850 pubmed publisher
    ..We hypothesized that maintenance therapy with hypomethylating agents (HMA), including decitabine (DAC) and azacitidine (AZA) after induction/consolidation, can be used for MRD elimination to ultimately prolong relapse ..
  33. Saito S, Iida A, Sekine A, Kawauchi S, Higuchi S, Ogawa C, et al. Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. J Hum Genet. 2003;48:249-70 pubmed
    ..These variants should contribute to studies designed to investigate possible correlations between genotypes and phenotypes of disease susceptibility or responsiveness to drug therapy. ..
  34. Gotoh H, Zinna R, Ishikawa Y, Miyakawa H, Ishikawa A, Sugime Y, et al. The function of appendage patterning genes in mandible development of the sexually dimorphic stag beetle. Dev Biol. 2017;422:24-32 pubmed publisher
    ..Tribolium studies, we focused on seven appendage patterning genes (Distal-less (Dll), aristaless (al), dachshund (dac), homothorax (hth), Epidermal growth factor receptor (Egfr), escargot (esg), and Keren (Krn)...
  35. Fojo T, Bates S. Strategies for reversing drug resistance. Oncogene. 2003;22:7512-23 pubmed
    ..re-expressing genes, including genes that affect drug sensitivity, using 5-azacytidine and 2'-deoxy-5-azacytidine (DAC, decitabine) as demethylating agents...
  36. Watanabe A, Fukami T, Nakajima M, Takamiya M, Aoki Y, Yokoi T. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. Drug Metab Dispos. 2009;37:1513-20 pubmed publisher
    ..In the present study, we found that human arylacetamide deacetylase (AADAC) efficiently hydrolyzed flutamide using recombinant AADAC expressed in COS7 cells...
  37. Kopparapu P, Abdelrazak Morsy M, Kanduri C, Kanduri M. Gene-body hypermethylation controlled cryptic promoter and miR26A1-dependent EZH2 regulation of TET1 gene activity in chronic lymphocytic leukemia. Oncotarget. 2017;8:77595-77608 pubmed publisher
    ..We show that treatment of CLL cell lines with 5-aza 2´-deoxycytidine (DAC) results in the activation of miR26A1, which causes decrease in both mRNA and protein levels of EZH2, which in turn ..
  38. Hosokawa M, Tanaka S, Ueda K, Iwakawa S. Different Schedule-Dependent Effects of Epigenetic Modifiers on Cytotoxicity by Anticancer Drugs in Colorectal Cancer Cells. Biol Pharm Bull. 2017;40:2199-2204 pubmed publisher
    ..As epigenetic modifiers, 3 DNA methyltransferase (DNMT) inhibitors such as decitabine (DAC), azacytidine (AC), and zebularine (Zeb), and 3 histone deacetylase (HDAC) inhibitors including trichostatin A (TSA)..
  39. Probst M, Beer M, Beer D, Jeno P, Meyer U, Gasser R. Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. J Biol Chem. 1994;269:21650-6 pubmed
    Microsomal arylacetamide deacetylase (DAC) competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens in many ..
  40. Doody E, Groebner J, Walker J, Frizol B, Tuma D, Fernandez D, et al. Ethanol metabolism by alcohol dehydrogenase or cytochrome P450 2E1 differentially impairs hepatic protein trafficking and growth hormone signaling. Am J Physiol Gastrointest Liver Physiol. 2017;:ajpgi.00027.2017 pubmed publisher
    ..Somewhat surprisingly, both NAS and DAC prevented impaired STAT5B nuclear translocation...
  41. Probst M, Jeno P, Meyer U. Purification and characterization of a human liver arylacetamide deacetylase. Biochem Biophys Res Commun. 1991;177:453-9 pubmed
    ..Antibodies raised against the deacetylase recognized the protein with high specificity. This report thus describes the first arylacetamide deacetylase in human liver.
  42. Ozols J. Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase. Biochemistry. 1998;37:10336-44 pubmed
    ..It is proposed here that such a motif may constitute a lumenal targeting signal for a set of single-membrane-spanning proteins that are otherwise structurally and functionally unrelated. ..
  43. Trickett J, Patel D, Knight B, Saggerson E, Gibbons G, Pease R. Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation. J Biol Chem. 2001;276:39522-32 pubmed
    In the current study, we have determined the cDNA and the genomic sequences of the arylacetamide deacetylase (AADA) gene in mice and rats. The AADA genes in the rat and mouse consist of five exons and have 2...
  44. Ross M, Crow J. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. J Biochem Mol Toxicol. 2007;21:187-96 pubmed
    ..Identification of the factors that lead to altered CE activities in HLMs will be important to characterize since several pharmaceutical agents, environmental toxicants, and endobiotics are metabolized by these enzymes. ..
  45. Muta K, Fukami T, Nakajima M, Yokoi T. N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity. Biochem Pharmacol. 2014;87:352-9 pubmed publisher
    Human arylacetamide deacetylase (AADAC) can hydrolyze clinical drugs such as flutamide, phenacetin, and rifamycins. AADAC is a glycoprotein, but the role of glycosylation remains unclear...
  46. Perry S, Kiragasi B, Dickman D, Ray A. The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory. Cell Rep. 2017;18:1337-1345 pubmed publisher
    ..Neuronal expression of HDAC6 rescued memory deficits, and we demonstrate that the N-terminal deacetylase (DAC) domain is required for this ability...
  47. Jiang J, Chen X, Zhong D. Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans. Front Pharmacol. 2017;8:846 pubmed publisher
    ..This study is the first to determine that human arylacetamide deacetylase (AADAC) is involved in 2-oxo-clopidogrel production from vicagrel in human intestine...
  48. Schwartzberg E, Barnett Itzhaki Z, Grotto I, Marom E. Strategies for patient empowerment through the promotion of medicines in Israel: regulatory framework for the pharmaceutical industry. Isr J Health Policy Res. 2017;6:50 pubmed publisher
    ..multiple strategies implemented in many countries to tackle this challenge including: disease awareness campaigns (DAC) to raise the public awareness to specific diseases, direct-to-consumer advertisement (DTCA) to raise the public ..
  49. Dorn M, Eschbach F, Hekmat D, Weuster Botz D. Influence of different packing methods on the hydrodynamic stability of chromatography columns. J Chromatogr A. 2017;1516:89-101 pubmed publisher
    ..Therefore, the effect of different column packing methods, i.e. dynamic axial compression (DAC), flow packing, and combinations of both on the hydrodynamic packing heterogeneity and stability of packings ..
  50. Finelli C, Follo M, Stanzani M, Parisi S, Clissa C, Mongiorgi S, et al. Clinical Impact of Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes. Curr Pharm Des. 2016;22:2349-57 pubmed
    ..Two drugs, azacitidine (AZA) and decitabine (DAC), defined, because of their proven mechanism of action, as DNA methyltransferase inhibitors (DNMTIs), or ..
  51. Miller S, Sly J, Itzkowitz S, Jandorf L. Racial/Ethnic Minorities Ineligible for Direct Access Colonoscopy (DAC): Identifying Patients Who Fall Through the Cracks. J Racial Ethn Health Disparities. 2015;2:86-92 pubmed publisher
    Patients ineligible for direct access colonoscopy (DAC) are typically referred for a pre-colonoscopy consultation with gastroenterology (GI)...
  52. Baldassari L, Rose J. Daclizumab: Development, Clinical Trials, and Practical Aspects of Use in Multiple Sclerosis. Neurotherapeutics. 2017;: pubmed publisher
    ..and Drug Administration for relapsing-remitting multiple sclerosis, and is now formally termed daclizumab beta (DAC-beta; Zinbryta™)...
  53. Bertelsen B, Stefansson H, Riff Jensen L, Melchior L, Mol Debes N, Groth C, et al. Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort. Biol Psychiatry. 2016;79:383-391 pubmed publisher
    ..GTS cohort (n = 111), recurrent exon-affecting microdeletions of four genes, including the gene encoding arylacetamide deacetylase (AADAC), were observed and merited further investigations...
  54. Rohling R, Hensen E, Pidko E. Multi-site cooperativity in alkali-exchanged faujasites for the production of biomass derived aromatics. Chemphyschem. 2017;: pubmed publisher
    The catalytic Diels-Alder cycloaddition/dehydration (DAC/D) reaction of furanics with ethylene is a promising route to bio-derived aromatics. The reaction can be catalyzed by alkali-exchanged faujasites...
  55. Wang L, Li T, Feng P, Song Y. Theoretical tuning of the singlet-triplet energy gap to achieve efficient long-wavelength thermally activated delayed fluorescence emitters: the impact of substituents. Phys Chem Chem Phys. 2017;19:21639-21647 pubmed publisher
    ..molecules using N3,N3,N6,N6-tetraphenyl-9H-carbazole-3,6-diamine (named DAC-II) as the electron donor and the 2-phenyl-quinoxaline-based electron acceptor are designed via introducing ..
  56. Zhao X, Wong K, Zhang D. Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina. Sci Rep. 2017;7:7920 pubmed publisher
    ..dopamine is synthesized and released by a specialized type of amacrine cell, the dopaminergic amacrine cell (DAC)...
  57. Yamasaki T, Fujinaga M, Mori W, Zhang Y, Wakizaka H, Nengaki N, et al. In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET. Sci Rep. 2017;7:14945 pubmed publisher
    ..N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC), a selective translocator protein PET ligand for neuroinflammation monitoring...
  58. Anand C, Garg R, Ghosh S, Nagaraja V. A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis. Biochem Biophys Res Commun. 2017;493:1204-1209 pubmed publisher
    ..Deacetylated HU (MtHUdAc) bound to relaxed DNA leading to the formation of looped and dense molecules as compared to open structures ..
  59. Fukami T, Iida A, Konishi K, Nakajima M. Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity. Biochem Pharmacol. 2016;116:153-61 pubmed publisher
    ..and inhibition studies using human liver microsomes (HLM) and recombinant enzymes revealed that human arylacetamide deacetylase (AADAC) is responsible for KC hydrolysis to form DAK, and confirmed that FMO3 is the enzyme responsible ..
  60. Lemon A, Pinet M. Measuring unintended effects in peacebuilding: What the field of international cooperation can learn from innovative approaches shaped by complex contexts. Eval Program Plann. 2017;: pubmed publisher
    ..The paper argues that OECD-DAC guidelines are not enough on their own to guide evaluators into exploration of unintended effects, and teams ..
  61. Ruby M, Massart J, Hunerdosse D, Schönke M, Correia J, Louie S, et al. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Rep. 2017;18:636-646 pubmed publisher
    ..We identified reduced hepatic activity of carboxylesterase 2 (CES2) and arylacetamide deacetylase (AADAC) in human obesity...
  62. Sandra N, Jailani A, Jain R, Mandal B. Genome characterization, infectivity assays of in vitro and in vivo infectious transcripts of soybean yellow mottle mosaic virus from India reveals a novel short mild genotype. Virus Res. 2017;232:96-105 pubmed publisher
    ..The infection was confirmed by DAC-ELISA, ISEM, RT-PCR and mechanical transmission to new plant species...