ABCA1

Summary

Gene Symbol: ABCA1
Description: ATP binding cassette subfamily A member 1
Alias: ABC-1, ABC1, CERP, HDLDT1, TGD, ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter A1, ATP-binding cassette, sub-family A (ABC1), member 1, cholesterol efflux regulatory protein, membrane-bound
Species: human
Products:     ABCA1

Top Publications

  1. Lawn R, Wade D, Garvin M, Wang X, Schwartz K, Porter J, et al. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999;104:R25-31 pubmed
    The ABC1 transporter was identified as the defect in Tangier disease by a combined strategy of gene expression microarray analysis, genetic mapping, and biochemical studies...
  2. Marcil M, Brooks Wilson A, Clee S, Roomp K, Zhang L, Yu L, et al. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux. Lancet. 1999;354:1341-6 pubmed
    ..This gene codes for the cholesterol-efflux regulatory protein (CERP). We investigated the presence of mutations in this gene in patients with familial HDL deficiency.
  3. Porchay I, Pean F, Bellili N, Royer B, Cogneau J, Chesnier M, et al. ABCA1 single nucleotide polymorphisms on high-density lipoprotein-cholesterol and overweight: the D.E.S.I.R. study. Obesity (Silver Spring). 2006;14:1874-9 pubmed
    The adenosine triphosphate-binding cassette A1 (ABCA1) gene plays a key role in reverse cholesterol transport. Some ABCA1 gene polymorphisms have been associated with high-density lipoprotein-cholesterol (HDL-C) concentrations...
  4. Yamauchi Y, Chang C, Hayashi M, Abe Dohmae S, Reid P, Chang T, et al. Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts. J Lipid Res. 2004;45:1943-51 pubmed
    ..has been suggested for cellular cholesterol and phospholipid release mediated by apolipoprotein A-I (apoA-I)/ABCA1. We investigated various factors involved in cholesterol mobilization related to this pathway...
  5. Flores Dorantes T, Arellano Campos O, Posadas Sánchez R, Villarreal Molina T, Medina Urrutia A, Romero Hidalgo S, et al. Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children. Clin Chim Acta. 2010;411:1214-7 pubmed publisher
    The effect of ABCA1 genetic variation on HDL-C levels has been widely documented, although studies in children are scarce...
  6. Wang F, Jia J. [Correlation of cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 polymorphisms with Alzheimer's disease]. Zhonghua Yi Xue Za Zhi. 2007;87:614-8 pubmed
    ..SNPs) A-->G in the intron 2 of cholesterol 24-hydroxylase (CYP46) gene and G-->A (R219K) in the exon 6 of ATP-binding cassette transporter A1 (ABCA1) gene with sporadic Alzheimer's disease (SAD) in the Han Chinese population.
  7. Delgado Lista J, Perez Martinez P, Perez Jimenez F, Garcia Rios A, Fuentes F, Marin C, et al. ABCA1 gene variants regulate postprandial lipid metabolism in healthy men. Arterioscler Thromb Vasc Biol. 2010;30:1051-7 pubmed publisher
    Genetic variants of ABCA1, an ATP-binding cassette (ABC) transporter, have been linked to altered atherosclerosis progression and fasting lipid concentration, mainly high-density lipoproteins and apolipoprotein A1; however, results from ..
  8. Katzov H, Chalmers K, Palmgren J, Andreasen N, Johansson B, Cairns N, et al. Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism. Hum Mutat. 2004;23:358-67 pubmed
    ..The gene encoding the ATP-binding cassette A1 transporter (ABCA1) resides within proximity of previously identified linkage peaks and represents a plausible biological candidate ..
  9. Li J, Wang L, Li Z, Pan W. Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Clin Exp Pharmacol Physiol. 2009;36:567-70 pubmed publisher
    ..present study, we investigated the effects of the R219K polymorphism of the ATP-binding cassette transporter A1 (ABCA1) gene on serum lipid levels and the response to statin therapy in Chinese patients with coronary heart disease (..
  10. Albrecht C, Simon Vermot I, Elliott J, Higgins C, Johnston D, Valabhji J. Leukocyte ABCA1 gene expression is associated with fasting glucose concentration in normoglycemic men. Metabolism. 2004;53:17-21 pubmed
    Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) mediates the efflux of cholesterol to apolipoprotein A1, a process necessary for high-density lipoprotein (HDL) formation and reverse cholesterol transport...

Detail Information

Publications62

  1. Lawn R, Wade D, Garvin M, Wang X, Schwartz K, Porter J, et al. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999;104:R25-31 pubmed
    The ABC1 transporter was identified as the defect in Tangier disease by a combined strategy of gene expression microarray analysis, genetic mapping, and biochemical studies...
  2. Marcil M, Brooks Wilson A, Clee S, Roomp K, Zhang L, Yu L, et al. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux. Lancet. 1999;354:1341-6 pubmed
    ..This gene codes for the cholesterol-efflux regulatory protein (CERP). We investigated the presence of mutations in this gene in patients with familial HDL deficiency.
  3. Porchay I, Pean F, Bellili N, Royer B, Cogneau J, Chesnier M, et al. ABCA1 single nucleotide polymorphisms on high-density lipoprotein-cholesterol and overweight: the D.E.S.I.R. study. Obesity (Silver Spring). 2006;14:1874-9 pubmed
    The adenosine triphosphate-binding cassette A1 (ABCA1) gene plays a key role in reverse cholesterol transport. Some ABCA1 gene polymorphisms have been associated with high-density lipoprotein-cholesterol (HDL-C) concentrations...
  4. Yamauchi Y, Chang C, Hayashi M, Abe Dohmae S, Reid P, Chang T, et al. Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts. J Lipid Res. 2004;45:1943-51 pubmed
    ..has been suggested for cellular cholesterol and phospholipid release mediated by apolipoprotein A-I (apoA-I)/ABCA1. We investigated various factors involved in cholesterol mobilization related to this pathway...
  5. Flores Dorantes T, Arellano Campos O, Posadas Sánchez R, Villarreal Molina T, Medina Urrutia A, Romero Hidalgo S, et al. Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children. Clin Chim Acta. 2010;411:1214-7 pubmed publisher
    The effect of ABCA1 genetic variation on HDL-C levels has been widely documented, although studies in children are scarce...
  6. Wang F, Jia J. [Correlation of cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 polymorphisms with Alzheimer's disease]. Zhonghua Yi Xue Za Zhi. 2007;87:614-8 pubmed
    ..SNPs) A-->G in the intron 2 of cholesterol 24-hydroxylase (CYP46) gene and G-->A (R219K) in the exon 6 of ATP-binding cassette transporter A1 (ABCA1) gene with sporadic Alzheimer's disease (SAD) in the Han Chinese population.
  7. Delgado Lista J, Perez Martinez P, Perez Jimenez F, Garcia Rios A, Fuentes F, Marin C, et al. ABCA1 gene variants regulate postprandial lipid metabolism in healthy men. Arterioscler Thromb Vasc Biol. 2010;30:1051-7 pubmed publisher
    Genetic variants of ABCA1, an ATP-binding cassette (ABC) transporter, have been linked to altered atherosclerosis progression and fasting lipid concentration, mainly high-density lipoproteins and apolipoprotein A1; however, results from ..
  8. Katzov H, Chalmers K, Palmgren J, Andreasen N, Johansson B, Cairns N, et al. Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism. Hum Mutat. 2004;23:358-67 pubmed
    ..The gene encoding the ATP-binding cassette A1 transporter (ABCA1) resides within proximity of previously identified linkage peaks and represents a plausible biological candidate ..
  9. Li J, Wang L, Li Z, Pan W. Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Clin Exp Pharmacol Physiol. 2009;36:567-70 pubmed publisher
    ..present study, we investigated the effects of the R219K polymorphism of the ATP-binding cassette transporter A1 (ABCA1) gene on serum lipid levels and the response to statin therapy in Chinese patients with coronary heart disease (..
  10. Albrecht C, Simon Vermot I, Elliott J, Higgins C, Johnston D, Valabhji J. Leukocyte ABCA1 gene expression is associated with fasting glucose concentration in normoglycemic men. Metabolism. 2004;53:17-21 pubmed
    Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) mediates the efflux of cholesterol to apolipoprotein A1, a process necessary for high-density lipoprotein (HDL) formation and reverse cholesterol transport...
  11. Harada T, Imai Y, Nojiri T, Morita H, Hayashi D, Maemura K, et al. A common Ile 823 Met variant of ATP-binding cassette transporter A1 gene (ABCA1) alters high density lipoprotein cholesterol level in Japanese population. Atherosclerosis. 2003;169:105-12 pubmed
    Recently, variants in ATP-binding cassette transporter A1 (ABCA1) were demonstrated to be associated with increased level of high density lipoprotein cholesterol (HDL-C) and decreased risk of coronary artery disease (CAD) in Caucasians...
  12. Villarreal Molina M, Flores Dorantes M, Arellano Campos O, Villalobos Comparan M, Rodriguez Cruz M, Miliar Garcia A, et al. Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Diabetes. 2008;57:509-13 pubmed
    The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos...
  13. Singaraja R, Brunham L, Visscher H, Kastelein J, Hayden M. Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene. Arterioscler Thromb Vasc Biol. 2003;23:1322-32 pubmed
    Approximately 50 mutations and many single nucleotide polymorphisms have been described in the ABCA1 gene, with mutations leading to Tangier disease and familial hypoalphalipoproteinemia...
  14. Soro Paavonen A, Naukkarinen J, Lee Rueckert M, Watanabe H, Rantala E, Soderlund S, et al. Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL. J Lipid Res. 2007;48:1409-16 pubmed
    HDL promotes cholesterol efflux from peripheral cells via ABCA1 in the first step of reverse cholesterol transport (RCT)...
  15. Neufeld E, Stonik J, Demosky S, Knapper C, Combs C, Cooney A, et al. The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J Biol Chem. 2004;279:15571-8 pubmed
    We have previously established that the ABCA1 transporter, which plays a critical role in the lipidation of extracellular apolipoprotein acceptors, traffics between late endocytic vesicles and the cell surface (Neufeld, E. B., Remaley, A...
  16. Denis M, Haidar B, Marcil M, Bouvier M, Krimbou L, Genest J. Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). J Biol Chem. 2004;279:7384-94 pubmed
    The dynamics of ABCA1-mediated apoA-I lipidation were investigated in intact human fibroblasts induced with 22(R)-hydroxycholesterol and 9-cis-retinoic acid (stimulated cells)...
  17. Kakko S, Kelloniemi J, von Rohr P, Hoeschele I, Tamminen M, Brousseau M, et al. ATP-binding cassette transporter A1 locus is not a major determinant of HDL-C levels in a population at high risk for coronary heart disease. Atherosclerosis. 2003;166:285-90 pubmed
    ATP-binding cassette transporter A1 (ABCA1) transports cellular cholesterol to lipid-poor apolipoproteins...
  18. Vergeer M, Brunham L, Koetsveld J, Kruit J, Verchere C, Kastelein J, et al. Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction. Diabetes Care. 2010;33:869-74 pubmed publisher
    ..beta-Cell deficiency for the ATP binding cassette transporter A1 (ABCA1), which mediates the efflux of cellular cholesterol, leads to altered intracellular ..
  19. Singaraja R, Fievet C, Castro G, James E, Hennuyer N, Clee S, et al. Increased ABCA1 activity protects against atherosclerosis. J Clin Invest. 2002;110:35-42 pubmed
    The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol transport pathway by mediating lipid efflux from macrophages...
  20. Zwarts K, Clee S, Zwinderman A, Engert J, Singaraja R, Loubser O, et al. ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels. Clin Genet. 2002;61:115-25 pubmed
    The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary artery disease (CAD), and that single ..
  21. Romero Hidalgo S, Villarreal Molina T, Gonzalez Barrios J, Canizales Quinteros S, Rodríguez Arellano M, Yañez Velazco L, et al. Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women. J Nutr. 2012;142:278-83 pubmed publisher
    The R230C variant of the ATP-binding cassette transporter A1 (ABCA1) gene has been consistently associated with decreased HDL-cholesterol (HDL-C) concentrations in several studies in the Mexican mestizo population...
  22. Smith B, Land H. Anticancer activity of the cholesterol exporter ABCA1 gene. Cell Rep. 2012;2:580-90 pubmed publisher
    The ABCA1 protein mediates the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A-I...
  23. Genvigir F, Soares S, Hirata M, Willrich M, Arazi S, Rebecchi I, et al. Effects of ABCA1 SNPs, including the C-105T novel variant, on serum lipids of Brazilian individuals. Clin Chim Acta. 2008;389:79-86 pubmed publisher
    b>ABCA1 plays an important role in HDL metabolism. Single nucleotide polymorphisms (SNPs) in ABCA1 gene were associated with variation in plasma HDL-c.
  24. Villarreal Molina T, Posadas Romero C, Romero Hidalgo S, Antúnez Argüelles E, Bautista Grande A, Vargas Alarcon G, et al. The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study. PLoS ONE. 2012;7:e49285 pubmed publisher
    b>ABCA1 genetic variation is known to play a role in HDL-C levels and various studies have also implicated ABCA1 variation in cardiovascular risk...
  25. Li Y, Tang K, Zhou K, Wei Z, Zeng Z, He L, et al. Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease. Mol Biol Rep. 2012;39:1809-13 pubmed publisher
    ..studies have been conducted to investigate the relationship between the ATP-binding cassette transporter A1 (ABCA1) R219K polymorphism and coronary heart disease (CHD). However, the results have been inconclusive...
  26. Takahashi K, Kimura Y, Kioka N, Matsuo M, Ueda K. Purification and ATPase activity of human ABCA1. J Biol Chem. 2006;281:10760-8 pubmed
    ATP-binding cassette protein A1 (ABCA1) plays a major role in cholesterol homeostasis and high density lipoprotein metabolism...
  27. Martin M, Gonzalez P, Reguero J, Batalla A, Garcia Castro M, Coto E, et al. ABCA1 polymorphisms and prognosis after myocardial infarction in young patients. Int J Cardiol. 2006;110:267-8 pubmed
    ..We have analysed three polymorphisms of the ABCA1 gene (-477C/T, R219 K, and I883M) in a cohort of young male survivors of myocardial infarction in order to know ..
  28. Brousseau M, Schaefer E, Dupuis J, Eustace B, Van Eerdewegh P, Goldkamp A, et al. Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds. J Lipid Res. 2000;41:433-41 pubmed
    ..These results establish a causal role for mutations in hABC-1 in TD and indicate that this transporter has a critical function in the regulation of intracellular lipid trafficking that dramatically affects plasma HDL cholesterol levels...
  29. van Dam M, de Groot E, Clee S, Hovingh G, Roelants R, Brooks Wilson A, et al. Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study. Lancet. 2002;359:37-42 pubmed
    ..Cholesterol efflux is mediated by the ATP-binding cassette A1 transporter (ABCA1), the rate-limiting step in the production of HDL...
  30. Ho Hong S, Rhyne J, Zeller K, Miller M. Novel ABCA1 compound variant associated with HDL cholesterol deficiency. Biochim Biophys Acta. 2002;1587:60-4 pubmed
    The recent discovery of an ATP-binding cassette transporter, ABCA1, as an important regulator of high density lipoprotein (HDL) metabolism and reverse cholesterol transport has facilitated the identification of novel variants associated ..
  31. Zhao S, Xiao Z, Li Q, Nie S, Tan L, Jiang B, et al. [Relationship between ATP-binding cassette transporter 1 R219K genetic variation and blood lipids]. Zhonghua Yi Xue Za Zhi. 2004;84:1421-5 pubmed
    To investigate whether ATP-binding cassette transporter 1 (ABCA1) R219K genetic variation is correlated with blood lipids.
  32. Whiting B, Anderson J, Muhlestein J, Horne B, Bair T, Pearson R, et al. Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease. Am Heart J. 2005;150:243-50 pubmed
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  33. Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette J, et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet. 1999;22:352-5 pubmed
    ..and D9S1866 on chromosome 9q31, in which we found the gene encoding human ATP cassette-binding transporter 1 (ABC1)...
  34. Santamarina Fojo S, Peterson K, Knapper C, Qiu Y, Freeman L, Cheng J, et al. Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci U S A. 2000;97:7987-92 pubmed
    The ABCA1 gene, a member of the ATP-binding cassette A (ABCA1) transporter superfamily, encodes a membrane protein that facilitates the cellular efflux of cholesterol and phospholipids...
  35. Tsai M, Ordovas J, Li N, Straka R, Hanson N, Arends V, et al. Effect of fenofibrate therapy and ABCA1 polymorphisms on high-density lipoprotein subclasses in the Genetics of Lipid Lowering Drugs and Diet Network. Mol Genet Metab. 2010;100:118-22 pubmed publisher
    Previous studies have shown that ATP-binding cassette transporter 1 (ABCA1) polymorphisms associated with increased ABCA1 expression result in increased small HDL (high-density lipoprotein) subclass particle concentration...
  36. Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Hosomi N, et al. Hyperglycemia suppresses ABCA1 expression in vascular smooth muscle cells. Horm Metab Res. 2010;42:241-6 pubmed publisher
    Hyperglycemia is a major risk factor for atherosclerotic disease. The ATP-binding cassette transporter A1 (ABCA1) functions as a pivotal regulator of lipid efflux from cells to apolipoproteins and is thus involved in lowering the risk of ..
  37. Frikke Schmidt R. Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population. Atherosclerosis. 2010;208:305-16 pubmed publisher
    ..This review focuses on whether both rare and common genetic variation in ABCA1 contributes to plasma levels of HDL cholesterol and to risk of IHD in the general population, and further seeks to ..
  38. Vaughan A, Tang C, Oram J. ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation. J Lipid Res. 2009;50:285-92 pubmed publisher
    b>ABCA1 exports cholesterol and phospholipids from cells by a multistep pathway that involves forming cell surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling ..
  39. Costet P, Lalanne F, Gerbod Giannone M, Molina J, Fu X, Lund E, et al. Retinoic acid receptor-mediated induction of ABCA1 in macrophages. Mol Cell Biol. 2003;23:7756-66 pubmed
    b>ABCA1, the mutant molecule in Tangier Disease, mediates efflux of cellular cholesterol to apoA-I and is induced by liver X receptor (LXR)/retinoid X receptor (RXR) transcription factors...
  40. Chu L, Li Y, Li Z, Tang A, Cheung B, Leung R, et al. A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer's disease in Chinese. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:1007-13 pubmed
    Recent genetic studies have shown that variants of the ATP-binding cassette transporter A1, ABCA1, may be implicated in the pathogenesis of Alzheimer's disease (AD)...
  41. Probst M, Thumann H, Aslanidis C, Langmann T, Buechler C, Patsch W, et al. Screening for functional sequence variations and mutations in ABCA1. Atherosclerosis. 2004;175:269-79 pubmed
    Mutations in the ATP-binding cassette 1 transporter gene (ABCA1) are responsible for the genetic HDL-deficiency syndromes, which are characterized by severely diminished plasma HDL-C levels and a predisposition to cardiovascular disease ..
  42. Singaraja R, Visscher H, James E, Chroni A, Coutinho J, Brunham L, et al. Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro. Circ Res. 2006;99:389-97 pubmed
    Mutations in ATP-binding cassette transporter A1 (ABCA1) cause Tangier disease and familial hypoalphalipoproteinemia, resulting in low to absent plasma high-density lipoprotein cholesterol levels...
  43. Passarelli M, Tang C, McDonald T, O Brien K, Gerrity R, Heinecke J, et al. Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells. Diabetes. 2005;54:2198-205 pubmed
    ..The ATP-binding cassette transporter A1 (ABCA1) is an atheroprotective cell protein that mediates cholesterol transport from cells to apolipoprotein (apo) A-I, ..
  44. Pasdar A, Yadegarfar G, Cumming A, Whalley L, St Clair D, MacLeod M. The effect of ABCA1 gene polymorphisms on ischaemic stroke risk and relationship with lipid profile. BMC Med Genet. 2007;8:30 pubmed
    ..The ATP Binding Cassette Transporter (ABCA1) is a key gene involved in lipid metabolism...
  45. Hodoglugil U, Williamson D, Huang Y, Mahley R. Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks. Atherosclerosis. 2005;183:199-212 pubmed
    ..of atherosclerosis is generally attributed to its role in reverse cholesterol transport, and the ATP binding cassette transporter A1 (ABCA1) is a key element of this process...
  46. Duong P, Collins H, Nickel M, Lund Katz S, Rothblat G, Phillips M. Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. J Lipid Res. 2006;47:832-43 pubmed
    The nascent HDL created by ABCA1-mediated efflux of cellular phospholipid (PL) and free (unesterified) cholesterol (FC) to apolipoprotein A-I (apoA-I) has not been defined...
  47. Huang Y, Wu Y, Liu R, Fan P, Zhang J, Wang F, et al. Differential effect of ATP binding cassette transporter A1 R219K and cholesteryl ester transfer protein TaqIB genotypes on HDL-C levels in overweight/obese and non-obese Chinese subjects. Acta Cardiol. 2011;66:231-7 pubmed
    ATP-binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) are involved in the HDL metabolism and play a key role in reverse cholesterol transport...
  48. Smith J, Waelde C, Horwitz A, Zheng P. Evaluation of the role of phosphatidylserine translocase activity in ABCA1-mediated lipid efflux. J Biol Chem. 2002;277:17797-803 pubmed
    The following two theories for the mechanism of ABCA1 in lipid efflux to apolipoprotein acceptors have been proposed: 1) that ABCA1 directly binds the apolipoprotein ligand and then facilitates lipid efflux and 2) that ABCA1 acts as a ..
  49. Sporstøl M, Mousavi S, Eskild W, Roos N, Berg T. ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. BMC Mol Biol. 2007;8:5 pubmed
    Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport...
  50. Sandhofer A, Iglseder B, Kaser S, Morè E, Paulweber B, Patsch J. The influence of two variants in the adenosine triphosphate-binding cassette transporter 1 gene on plasma lipids and carotid atherosclerosis. Metabolism. 2008;57:1398-404 pubmed publisher
    Variants in the adenosine triphosphate-binding-cassette transporter 1 (ABCA1) gene are known to affect high-density lipoprotein cholesterol and plasma triglycerides and the development of atherosclerosis...
  51. Yamauchi Y, Hayashi M, Abe Dohmae S, Yokoyama S. Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly. J Biol Chem. 2003;278:47890-7 pubmed
    ATP-binding cassette transporter A1 (ABCA1) plays an essential role in the helical apolipoprotein-mediated assembly of high density lipoprotein, and the apolipoporteins stabilize ABCA1 against calpain-mediated degradation during the ..
  52. See R, Caday Malcolm R, Singaraja R, Zhou S, Silverston A, Huber M, et al. Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux. J Biol Chem. 2002;277:41835-42 pubmed
    ATP-binding cassette A1 (ABCA1) is a key mediator of cholesterol and phospholipid efflux to apolipoprotein particles...
  53. Hong S, Rhyne J, Zeller K, Miller M. ABCA1(Alabama): a novel variant associated with HDL deficiency and premature coronary artery disease. Atherosclerosis. 2002;164:245-50 pubmed
    The ATP-binding cassette transporter, ABCA1, is a member of the ABC superfamily of proteins involved in the active transport of substrates across cellular membranes...
  54. Saleheen D, Khanum S, Haider S, Nazir A, Ahmad U, Khalid H, et al. A novel haplotype in ABCA1 gene effects plasma HDL-C concentration. Int J Cardiol. 2007;115:7-13 pubmed
    ATP-binding cassette transporter 1 (ABCA1) is a trans-membrane protein responsible for the efflux of cholesterol and phospholipids across the cell membrane, an essential step in the reverse cholesterol transport system...
  55. Marques Vidal P, Bochud M, Paccaud F, Waterworth D, Bergmann S, Preisig M, et al. No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels. Atherosclerosis. 2010;211:551-7 pubmed publisher
    ..To assess the relationships and possible interactions between polymorphisms related to HDL levels and alcohol consumption...
  56. Hozoji M, Munehira Y, Ikeda Y, Makishima M, Matsuo M, Kioka N, et al. Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux. J Biol Chem. 2008;283:30057-63 pubmed publisher
    ..Therefore, the ABCA1 gene, the product of which mediates secretion of cholesterol, is highly regulated at both the transcriptional and ..
  57. Frikke Schmidt R, Nordestgaard B, Jensen G, Tybjaerg Hansen A. Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population. J Clin Invest. 2004;114:1343-53 pubmed
    Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare HDL-deficiency syndrome...
  58. Iatan I, Bailey D, Ruel I, Hafiane A, Campbell S, Krimbou L, et al. Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis. J Lipid Res. 2011;52:2043-55 pubmed publisher
    Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the "high-capacity binding site" (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation...
  59. Ramírez C, Davalos A, Goedeke L, Salerno A, Warrier N, Cirera Salinas D, et al. MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 2011;31:2707-14 pubmed publisher
    The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of macrophage cholesterol efflux and protects cells from excess intracellular cholesterol accumulation; however, the mechanism involved in posttranscriptional ..
  60. Roosbeek S, Peelman F, Verhee A, Labeur C, Caster H, Lensink M, et al. Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter. J Biol Chem. 2004;279:37779-88 pubmed
    ..To study the possible regulation of the ABCA1 transporter by CK2, we expressed the recombinant cytoplasmic domains of ABCA1, NBD1+R1 and NBD2+R2...
  61. Frikke Schmidt R, Nordestgaard B, Jensen G, Steffensen R, Tybjaerg Hansen A. Genetic variation in ABCA1 predicts ischemic heart disease in the general population. Arterioscler Thromb Vasc Biol. 2008;28:180-6 pubmed
    We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms (SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population.
  62. Bhattacharjee J, Ietta F, Giacomello E, Bechi N, Romagnoli R, Fava A, et al. Expression and localization of ATP binding cassette transporter A1 (ABCA1) in first trimester and term human placenta. Placenta. 2010;31:423-30 pubmed publisher
    b>ATP binding cassette transporter A1 (ABCA1) is a membrane transporter which performs cellular efflux of cholesterol and phospholipid...