ABCG2

Summary

Gene Symbol: ABCG2
Description: ATP binding cassette subfamily G member 2 (Junior blood group)
Alias: ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1, ATP-binding cassette sub-family G member 2, ABC transporter, ATP-binding cassette transporter G2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), breast cancer resistance protein, mitoxantrone resistance-associated protein, multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2, placenta specific MDR protein, placenta-specific ATP-binding cassette transporter, urate exporter
Species: human

Top Publications

  1. doi Suppression of ABCG2 inhibits cancer cell proliferation
    Zhong Chen
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People s Republic of China
    Int J Cancer 126:841-51. 2010
  2. pmc A multidrug resistance transporter from human MCF-7 breast cancer cells
    L A Doyle
    Greenebaum Cancer Center of the University of Maryland, Baltimore MD 21201, USA
    Proc Natl Acad Sci U S A 95:15665-70. 1998
  3. ncbi RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response
    Herman Burger
    Department of Medical Oncology, Erasmus Medical Center Rotterdam Daniel den Hoed Kliniek Josephine Nefkens Institute, 3000 DR Rotterdam, The Netherlands
    Clin Cancer Res 9:827-36. 2003
  4. doi Knockdown of caveolin-1 decreases activity of breast cancer resistance protein (BCRP/ABCG2) and increases chemotherapeutic sensitivity
    Melanie Herzog
    Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 383:1-11. 2011
  5. pmc Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25
    Li Shu Chuan Cheng
    Division of Information Science, City of Hope Medical Center, Duarte, CA, USA
    Am J Hum Genet 75:498-503. 2004
  6. pmc Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2
    Orsolya Polgar
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 13N240, Bethesda, Maryland 20892, USA
    Biochemistry 49:2235-45. 2010
  7. ncbi Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists
    Bettina Ebert
    Institute for Food Toxicology, University of Veterinary Medicine Hannover, Foundation, Bischofsholern Damm 15 115, 30173 Hannover, Germany
    Carcinogenesis 26:1754-63. 2005
  8. ncbi ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition
    Floris A de Jong
    Department of Medical Oncology, Erasmus University MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Clin Cancer Res 10:5889-94. 2004
  9. ncbi BCRP gene polymorphisms are associated with susceptibility and survival of diffuse large B-cell lymphoma
    Li Li Hu
    Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou 510275, P R China
    Carcinogenesis 28:1740-4. 2007
  10. ncbi Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Cell Biochem 296:85-95. 2007

Research Grants

  1. ABC Transporters in CNS Penetration of Camptothecins
    Christopher Waters; Fiscal Year: 2007
  2. Medications Development for the Pregnant Opiate Addict
    Mahmoud S Ahmed; Fiscal Year: 2010
  3. JOHN DAVID CASTLE; Fiscal Year: 2015
  4. ABCs of Cholesterol Regulation in the Insulin Secretory Pathway
    JOHN DAVID CASTLE; Fiscal Year: 2011
  5. Structure and Mechanism of Maltose Transport
    Jue Chen; Fiscal Year: 2009
  6. Hight Throughput Screening for inhibitors of the ABC transporter ABCB6
    Partha C Krishnamurthy; Fiscal Year: 2012
  7. Davide Trotti; Fiscal Year: 2015
  8. Functions of MRP2 and MRP3 in Drug Disposition
    James M Gallo; Fiscal Year: 2011
  9. THOMAS PAUL DAVIS; Fiscal Year: 2014
  10. Tatiana Nanovskaya; Fiscal Year: 2015

Patents

  1. Method for predicting a drug transport capability by abcg2 polymorphisms

Detail Information

Publications278 found, 100 shown here

  1. doi Suppression of ABCG2 inhibits cancer cell proliferation
    Zhong Chen
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People s Republic of China
    Int J Cancer 126:841-51. 2010
    The ATP-binding cassette efflux transporter, ABCG2, is widely expressed in a variety of normal tissues, stem cells, as well as cancer cells...
  2. pmc A multidrug resistance transporter from human MCF-7 breast cancer cells
    L A Doyle
    Greenebaum Cancer Center of the University of Maryland, Baltimore MD 21201, USA
    Proc Natl Acad Sci U S A 95:15665-70. 1998
    ..a 655-aa [corrected] member of the ATP-binding cassette superfamily of transporters that we term breast cancer resistance protein (BCRP)...
  3. ncbi RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response
    Herman Burger
    Department of Medical Oncology, Erasmus Medical Center Rotterdam Daniel den Hoed Kliniek Josephine Nefkens Institute, 3000 DR Rotterdam, The Netherlands
    Clin Cancer Res 9:827-36. 2003
    ..The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease...
  4. doi Knockdown of caveolin-1 decreases activity of breast cancer resistance protein (BCRP/ABCG2) and increases chemotherapeutic sensitivity
    Melanie Herzog
    Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 383:1-11. 2011
    The ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) is supposed to be a major determinant of the multidrug resistance phenotype of tumors by extruding chemically diverse cytostatic drugs out of tumor cells...
  5. pmc Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25
    Li Shu Chuan Cheng
    Division of Information Science, City of Hope Medical Center, Duarte, CA, USA
    Am J Hum Genet 75:498-503. 2004
    ..Quantitative traits, including serum uric acid and creatinine, also showed a moderate linkage to this region. To our knowledge, this is the first genome-scan report to identify a genetic locus harboring a gout-susceptibility gene...
  6. pmc Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2
    Orsolya Polgar
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 13N240, Bethesda, Maryland 20892, USA
    Biochemistry 49:2235-45. 2010
    b>ABCG2 is an ATP-binding cassette half-transporter important in normal tissue protection, drug distribution, and excretion. ABCG2 requires homodimerization for function, though the mechanism for dimerization has not been elucidated...
  7. ncbi Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists
    Bettina Ebert
    Institute for Food Toxicology, University of Veterinary Medicine Hannover, Foundation, Bischofsholern Damm 15 115, 30173 Hannover, Germany
    Carcinogenesis 26:1754-63. 2005
    b>Breast cancer resistance protein (BCRP/ABCG2) is known to actively transport various anticancer drugs and to restrict the uptake of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine from the gut lumen...
  8. ncbi ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition
    Floris A de Jong
    Department of Medical Oncology, Erasmus University MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Clin Cancer Res 10:5889-94. 2004
    The ATP-binding cassette transporter ABCG2 (breast cancer resistance protein) is an efflux protein that plays a role in host detoxification of various xenobiotic substrates, including the irinotecan metabolite 7- ethyl-10-..
  9. ncbi BCRP gene polymorphisms are associated with susceptibility and survival of diffuse large B-cell lymphoma
    Li Li Hu
    Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou 510275, P R China
    Carcinogenesis 28:1740-4. 2007
    To date, the biological significance of breast cancer resistance protein (BCRP) G34A and C421A polymorphisms is largely unknown...
  10. ncbi Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Cell Biochem 296:85-95. 2007
    ..on three ABC drug transporter proteins, P-glycoprotein (P-gp or ABCB1), mitoxantrone resistance protein (MXR or ABCG2) and multidrug resistance protein 1 (MRP1 or ABCC1) was investigated, to assess whether an ultimate metabolite ..
  11. ncbi Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization
    Kumie Kage
    Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan
    Int J Cancer 97:626-30. 2002
    b>Breast cancer resistance protein (BCRP) is a half-molecule ABC transporter highly expressed in mitoxantrone-resistant cells. In our study we established PA317 transfectants expressing Myc-tagged BCRP (MycBCRP) or HA-tagged BCRP (HABCRP)...
  12. ncbi Purification of breast cancer resistance protein ABCG2 and role of arginine-482
    A Pozza
    Institut de Biologie et Chimie des Proteines, UMR5086 CNRS Université de Lyon et IFR128 BioSciences Lyon Gerland, 7 passage du Vercors, 69367, Lyon Cedex 07, France
    Cell Mol Life Sci 63:1912-22. 2006
    Human ABCG2 was efficiently overexpressed in insect cell membranes, solubilized with 3-[(3-cholamidopropyl)dimethyl ammonio]-1-propanesulfonate, and purified through N-terminal hexahistidine tag...
  13. ncbi ABCG2 expression is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma
    Shigeru Tsunoda
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Oncology 71:251-8. 2006
    ATP-binding cassette, subfamily G, member 2 (ABCG2) is a new member of the superfamily of ATP-binding cassette transporter proteins and known to be not only a member of the membrane transporters implicated in multidrug resistance, but ..
  14. doi Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy
    Dong Wook Kim
    Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea
    Epilepsy Res 84:86-90. 2009
    ..transporters participate in drug disposition and response in various conditions, and many polymorphisms in ABC transporter genes have been recognized in association with altered transporter functions of various drugs...
  15. doi Interleukin-1 beta and tumor necrosis factor-alpha increase ABCG2 expression in MCF-7 breast carcinoma cell line and its mitoxantrone-resistant derivative, MCF-7/MX
    Fatemeh Mosaffa
    Biotechnology and Immunology Research Centers, Mashhad University of Medical Sciences, Mashhad, Iran
    Inflamm Res 58:669-76. 2009
    In this study, we aimed to evaluate the influence of proinflammatory cytokines on ABCG2 expression and function in human MCF-7 breast cancer cell line and its mitoxantrone-resistant derivative MCF-7/MX.
  16. pmc Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1
    Takashi Sugiyama
    Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 404:853-8. 2011
    Human breast cancer resistance protein (BCRP)/MXR/ABCG2 is a well-recognized ABC half-transporter that is highly expressed at the apical membrane of many normal tissues and cancer cells...
  17. doi Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Pharmacogenomics 12:319-25. 2011
    To determine the association between polymorphisms of the multidrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs.
  18. ncbi Heme Oxygenase-1 and breast cancer resistance protein protect against heme-induced toxicity
    Frank A D T G Wagener
    Department of Orthodontics and Craniofacial Biology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Curr Pharm Des 19:2698-707. 2013
    ..We postulated that overexpression of Heme Oxygenase-1 (HO-1) and Breast Cancer Resistance Protein (BCRP) would protect against heme-induced cytotoxicity...
  19. doi Opposite regulation of hepatic breast cancer resistance protein in type 1 and 2 diabetes mellitus
    Lei He
    Center for Drug Safety Evaluations and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China
    Eur J Pharmacol 724:185-92. 2014
    ..The present study aimed to explore changes in hepatic breast cancer resistance protein (BCRP) expression and functions, as well as the possible underlying mechanisms, in type 2 diabetic ..
  20. doi Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum
    Theodora G H A Tucker
    Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Biochem Pharmacol 83:279-85. 2012
    The ATP-binding cassette (ABC) transporters breast cancer resistance protein (BCRP), multidrug resistance-associated protein 2 (MRP2), and P-glycoprotein (Pgp) are important in the distribution and elimination of many drugs and endogenous ..
  21. pmc Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter
    Csilla Ozvegy-Laczka
    Membrane Research Group of the Hungarian Academy of Sciences, Semmelweis University and National Blood Center, 1113 Budapest, Hungary
    J Biol Chem 283:26059-70. 2008
    Human ABCG2 is a plasma membrane glycoprotein working as a homodimer or homo-oligomer...
  22. ncbi A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
    R Allikmets
    Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Cancer Res 58:5337-9. 1998
    ..The gene, ABCP, produces two transcripts that differ at the 5' end and encode the same 655-amino acid protein...
  23. pmc Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2
    Chun Ling Dai
    State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 68:7905-14. 2008
    ..multidrug resistance (MDR) due to overexpression of ABC subfamily B member 1 (ABCB1) and ABC subfamily G member 2 (ABCG2) transporters...
  24. ncbi ABCG2 transports sulfated conjugates of steroids and xenobiotics
    Michiko Suzuki
    School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 278:22644-9. 2003
    ..In the present study, we investigated whether human wild type ABCG2 transports estrone 3-sulfate (E1S) using membrane vesicles from cDNA-transfected mouse lymphoma cell line (P388 ..
  25. pmc The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding
    Karin F K Ejendal
    Department of Chemistry and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Protein Sci 15:1597-607. 2006
    ..of the ATP-binding cassette (ABC) transporter superfamily, including P-glycoprotein and the half-transporter ABCG2, can confer multidrug resistance to cancer cells in culture by functioning as ATP-dependent efflux pumps...
  26. ncbi The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells
    Yingqiu Xie
    Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore 21201, USA
    J Biol Chem 283:3349-56. 2008
    ..a yeast two-hybrid screening to identify cellular proteins that were associated with Pim-1L, and we found the ABC transporter BCRP/ABCG2 as one of the potential interacting partners of Pim-1L...
  27. pmc ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides
    Huaqi Xiong
    Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Neurosci 29:5463-75. 2009
    ..Expression analyses of 273 BBB-related genes performed in this study showed that the drug transporter, ABCG2, was significantly upregulated in the brains of AD/CAA compared with age-matched controls...
  28. pmc ABCG2-dependent dye exclusion activity and clonal potential in epithelial cells continuously growing for 1 month from limbal explants
    Ozlem Barut Selver
    Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey
    Invest Ophthalmol Vis Sci 52:4330-7. 2011
    To determine changes in ABCG2-transport-dependent dye exclusion in outgrowths from limbal explants.
  29. ncbi The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models
    Pauline Breedveld
    Department of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Pharmacol 71:240-9. 2007
    ..We have tested whether this also applies to efflux from cells by breast cancer resistance protein (BCRP; ABCG2), which has been reported to transport folic acid, methotrexate, and methotrexate di- ..
  30. doi Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study
    Kristian M Bailey
    Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom
    Circ Cardiovasc Genet 3:276-85. 2010
    ..Pharmacogenetics aims to maximize benefits and minimize risks of drug treatment. Our objectives were to examine the influence of common variants of hepatic metabolism and transporter genes on the lipid-lowering response to statin therapy...
  31. ncbi BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia
    D Steinbach
    University Children s Hospital, Jena, Germany
    Leukemia 16:1443-7. 2002
    b>Breast cancer resistance protein (BCRP), also known as mitoxantrone resistance protein (MRX) or placenta ABC protein (ABC-P), is the second member of the ABCG subfamily of ABC transport proteins (gene symbol ABCG2)...
  32. doi P-glycoprotein down-regulates expression of breast cancer resistance protein in a drug-free state
    Hyun Bark
    Research Center for Resistant Cells and Department of Pharmacology, Chosun University Medical School, Gwangju, Republic of Korea
    FEBS Lett 582:2595-600. 2008
    This study investigated whether P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) are linked in terms of expression. RT-PCR and Western blot analyses showed that the lung cancer cell line SK-MES-1/WT expressed BCRP...
  33. ncbi Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
    Herman Burger
    Department of Medical Oncology, Erasmus Medical Center Rotterdam, Daniel den Hoed Kliniek Josephine Nefkens Institute, Rotterdam, The Netherlands
    Blood 104:2940-2. 2004
    ..We examined whether imatinib is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump that is frequently overexpressed in human tumors...
  34. ncbi Expression of multidrug resistance 1 (MDR1), multidrug resistance-related protein 1 (MRP1), lung resistance protein (LRP), and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia
    M Kourti
    Second Department of Pediatrics, Division of Hematology Oncology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int J Hematol 86:166-73. 2007
    The aim of this prospective study was to analyze the expression of messenger RNA of genes, such as MDR1, MRP1, BCRP, and LRP, implicated in the mechanism of multidrug resistance (MDR) in relation to the response to induction chemotherapy ..
  35. doi Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms
    Balasubramanian Poonkuzhali
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Drug Metab Dispos 36:780-95. 2008
    The hypothesis was tested that sequence diversity in breast cancer resistance protein (BCRP)'s cis-regulatory region is a significant determinant of BCRP expression...
  36. doi Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia
    Lorena L de Figueiredo-Pontes
    Hematology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Cytometry B Clin Cytom 74:163-8. 2008
    ....
  37. ncbi The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    S Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 7:1028-34. 2001
    ..Here we show that expression of the Bcrp1 (also known as Abcg2 murine/ABCG2 human) gene is a conserved feature of stem cells from a wide variety of sources...
  38. ncbi Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene
    K J Bailey-Dell
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1520:234-41. 2001
    The breast cancer resistance protein (BCRP) gene, formally known as ATP-binding cassette transporter G2 (ABCG2) gene, encodes an ABC half transporter that causes resistance to certain cancer chemotherapeutic drugs when transfected and ..
  39. ncbi Role of ABCG1 and other ABCG family members in lipid metabolism
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    J Lipid Res 42:1513-20. 2001
    ..In addition, new implications for the transcriptional control, as well as the intracellular routing and localization, of these proteins are presented...
  40. ncbi Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance
    Erin L Volk
    Wadsworth Center, Biggs Laboratories, New York State Department of Health, Albany, New York 12201 0509, USA
    Cancer Res 62:5035-40. 2002
    ..L. Volk et al., Cancer Res., 60: 3514-3521, 2000). These cells overexpress the breast cancer resistance protein (BCRP), and resistance to MTX as well as to MX was reversible by the BCRP inhibitor, GF120918...
  41. ncbi Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis
    Tavan Janvilisri
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 278:20645-51. 2003
    The human breast cancer resistance protein (BCRP, also know as ABCG2, MXR, or ABCP) is one of the more recently discovered ATP-binding cassette (ABC) transporters that confer resistance on cancer cells by mediating multidrug efflux...
  42. ncbi Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport
    Zhe Sheng Chen
    Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 63:4048-54. 2003
    b>ABCG2 is a plasma membrane efflux pump that is able to confer resistance to several anticancer agents, including mitoxantrone, camptothecins, anthracyclines, and flavopiridol...
  43. ncbi Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
    L Austin Doyle
    The University of Maryland Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA
    Oncogene 22:7340-58. 2003
    ..The new transporter was termed the breast cancer resistance protein (BCRP), because of its identification in MCF-7 human breast carcinoma cells...
  44. ncbi BCRP mRNA expression v. clinical outcome in 40 adult AML patients
    Bertil Uggla
    Department of Medicine, Orebro University Hospital, 701 85 Orebro, Sweden
    Leuk Res 29:141-6. 2005
    ..A recently described efflux pump, breast cancer resistance protein (BCRP), can be expressed in AML, but its clinical importance is uncertain...
  45. ncbi Association of the BCRP C421A polymorphism with nonpapillary renal cell carcinoma
    Yoshihito Korenaga
    Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Int J Cancer 117:431-4. 2005
    b>Breast cancer resistance protein (BCRP), the second member of the ATP-binding cassette membrane transporter family, has a single nucleotide polymorphism, C421A (resulting in Q141K), that is of functional importance...
  46. pmc Role of the breast cancer resistance protein (ABCG2) in drug transport
    Qingcheng Mao
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA
    AAPS J 7:E118-33. 2005
    The 72-kDa breast cancer resistance protein (BCRP) is the second member of the subfamily G of the human ATP binding cassette (ABC) transporter superfamily and thus also designated as ABCG2...
  47. pmc Aberrant promoter methylation of the ABCG2 gene in renal carcinoma
    Kenneth K W To
    Experimental Therapeutics Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Mol Cell Biol 26:8572-85. 2006
    b>ABCG2 is a ubiquitous ATP-binding cassette transmembrane protein that is important in clinical drug resistance. Little is known about the mechanism(s) regulating the expression of ABCG2...
  48. ncbi Pharmacogenetics of ABCG2 and adverse reactions to gefitinib
    George Cusatis
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Natl Cancer Inst 98:1739-42. 2006
    ..Gefitinib is a substrate for ABCG2 (ABCP, BCRP, MXR), a polymorphic efflux transporter protein that is highly expressed in the intestines and liver...
  49. ncbi In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugs
    Ai Tamura
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
    Drug Metab Pharmacokinet 22:428-40. 2007
    Since porphyrins are regarded as endogenous substrates for the ATP-binding cassette (ABC) transporter ABCG2, it is hypothesized that functional impairment owing to genetic polymorphisms or inhibition of ABCG2 by drugs may result in a ..
  50. doi Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis
    Richard B Warren
    Dermatological Sciences, The University of Manchester, Salford Royal Hospital, Manchester, UK
    J Invest Dermatol 128:1925-9. 2008
    ..SNPs within the efflux transporter genes ABCC1 (ATP-binding cassette, subfamily C, member 1) and ABCG2 (ATP-binding cassette, subfamily G, member 2) are associated with good response to methotrexate therapy in ..
  51. ncbi Human ABC transporters ABCG2 (BCRP) and ABCG4
    S Koshiba
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
    Xenobiotica 38:863-88. 2008
    1. The human ABC transporter ABCG2 is regarded as a member of the phase III system for xenobiotic metabolism, and it has been suggested that this efflux pump is responsible for protecting the body from toxic xenobiotics and for removing ..
  52. pmc Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival
    Erin R Gardner
    Clinical Pharmacology Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD, USA
    BJU Int 102:1694-9. 2008
    To determine if the C421A single nucleotide polymorphism (SNP) in the ATP-binding cassette transporter ABCG2 increases prostate cancer risk or affects survival.
  53. pmc Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations
    Tomoka Furukawa
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B 60 Nagatsuta, Midori ku, Yokohama, 226 8501, Japan
    Pharm Res 26:469-79. 2009
    Single nucleotide polymorphisms (SNPs) of the ATP-binding cassette (ABC) transporter ABCG2 gene have been suggested to be a significant factor in patients' responses to medication and/or the risk of diseases...
  54. pmc Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Federico Innocenti
    The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:2604-14. 2009
    ..We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients...
  55. pmc Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    Owen M Woodward
    Department of Physiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:10338-42. 2009
    ..Here we show using functional assays that human ATP-binding cassette, subfamily G, 2 (ABCG2), encoded by the ABCG2 gene contained in this region, is a hitherto unknown urate efflux transporter...
  56. doi Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma
    Ji Eun Kim
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mod Pathol 22:1312-20. 2009
    ..Expression of ABCG2 was detected in 52 of 55 (95%) cases and was high in 15 (27%) cases...
  57. doi Lack of ABCG2 expression and side population properties in human pluripotent stem cells
    Hui Zeng
    Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Stem Cells 27:2435-45. 2009
    The multidrug transporter ABCG2 in cell membranes enables various stem cells and cancer cells to efflux chemicals, including the fluorescent dye Hoechst 33342...
  58. doi Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancer
    Keiichi Akasaka
    Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Cancer Chemother Pharmacol 66:691-8. 2010
    b>ABCG2 is a half-size ATP-binding cassette transporter implicated in cellular gefitinib transport. Reportedly, the c...
  59. doi The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people
    Kazumasa Yamagishi
    Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Rheumatology (Oxford) 49:1461-5. 2010
    Recent genome-wide association and functional studies have shown that the ABCG2 gene encodes for a urate transporter, and a common causal ABCG2 variant, rs2231142, leads to elevated uric acid levels and prevalent gout among Whites and ..
  60. pmc Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype
    Anju Singh
    Johns Hopkins University, of Environmental Health Sciences, Bloomberg School of Public Health, E7624, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Mol Cancer Ther 9:2365-76. 2010
    ATP-binding cassette, subfamily G, member 2 (ABCG2) is expressed in both normal and cancer cells and plays a crucial role in side population (SP) formation and efflux of xenobiotics and drugs...
  61. doi A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample sets
    Amanda J Phipps-Green
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Hum Mol Genet 19:4813-9. 2010
    Genetic variation in ABCG2 (rs2231142, Q141K), encoding a uric acid transporter, is associated with gout in diverse populations...
  62. pmc Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells
    Yun Ju Chen
    Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan
    PLoS ONE 6:e21428. 2011
    ....
  63. pmc Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up
    Sagar Agarwal
    Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    Curr Pharm Des 17:2793-802. 2011
    ..may be in part due to limitations in drug delivery, influenced by the ABC drug efflux transporters P-gp and BCRP at the blood-brain and blood-tumor barriers, in brain tumor cells, as well as in brain tumor stem-like cells...
  64. pmc Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior
    Carole Saison
    National Institute of Blood Transfusion INTS, Paris, France
    Nat Genet 44:174-7. 2012
    The breast cancer resistance protein, also known as ABCG2, is one of the most highly studied ATP-binding cassette (ABC) transporters because of its ability to confer multidrug resistance...
  65. doi Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response
    Zsuzsa Erdei
    Membrane Research Group of the Hungarian Academy of Sciences, Semmelweis, University and National Blood Center, Diószegi u 64, 1113, Budapest, Hungary
    Eur Biophys J 42:169-79. 2013
    b>ABCG2 is a plasma membrane multidrug transporter with an established role in the cancer drug-resistance phenotype. This protein is expressed in a variety of tissues, including several types of stem cell...
  66. pmc Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules
    Owen M Woodward
    Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:5223-8. 2013
    ..Q141K ABCG2 mutation using a comparative approach, contrasting it with another disease-causing mutation in an ABC transporter, the deletion of Phe-508 (ΔF508) in the cystic fibrosis transmembrane conductance regulator (CFTR)...
  67. ncbi Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes
    K Miyake
    Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 59:8-13. 1999
    ..Two cDNAs of different lengths were isolated and designated MXR1 and MXR2...
  68. ncbi Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines
    D D Ross
    University of Maryland Greenebaum Cancer Center, Department of Medicine, University of Maryland School of Medicine, and Baltimore Veterans Medical Center, 21201, USA
    J Natl Cancer Inst 91:429-33. 1999
    ..b>Breast cancer resistance protein (BCRP) is a recently described adenosine triphosphate-binding cassette transporter associated with ..
  69. ncbi Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
    M Maliepaard
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Res 61:3458-64. 2001
    High expression of the Breast Cancer Resistance Protein (BCRP) gene has been shown to be involved in resistance to chemotherapeutic drugs...
  70. ncbi The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells
    Min Kim
    Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Clin Cancer Res 8:22-8. 2002
    The human ATP-binding cassette superfamily G (White) member 2 (ABCG2) gene and its murine homologue breast cancer resistance protein 1 (Bcrp1) are recently described ATP-binding cassette transporters associated with drug resistance in ..
  71. ncbi Expression of the breast cancer resistance protein in breast cancer
    Ian F Faneyte
    Department of Experimental Therapy, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Clin Cancer Res 8:1068-74. 2002
    The breast cancer resistance protein (BCRP) is involved in in vitro multidrug resistance and was first identified in the breast cancer cell line MCF7/AdrVp...
  72. ncbi Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)
    M M van den Heuvel-Eibrink
    Department of Hematology, University Hospital, Erasmus University, Rotterdam, The Netherlands
    Leukemia 16:833-9. 2002
    ..breast cancer-resistant protein (BCRP), the equivalent of mitoxantrone-resistant protein (MXR) or placental ABC transporter (ABCP), was described in AML...
  73. ncbi Low levels of ABCG2 expression in adult AML blast samples
    Brian L Abbott
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 100:4594-601. 2002
    Previous reports have suggested that the adenosine triphosphate-binding cassette protein ABCG2 (breast cancer resistance protein [BCRP], mitoxantrone resistance [MXR]) is associated with drug resistance in acute myeloid leukemia (AML)...
  74. pmc The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria
    Johan W Jonker
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 99:15649-54. 2002
    The breast cancer resistance protein (BCRPABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs...
  75. ncbi C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance
    Yasuo Imai
    Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo 170 8455, Japan
    Mol Cancer Ther 1:611-6. 2002
    b>Breast cancer resistance protein (BCRP) confers multidrug resistance to cancer cells against agents such as SN-38 (an active metabolite of irinotecan), mitoxantrone, and topotecan...
  76. ncbi Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia
    Marjolein A van der Pol
    Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
    Haematologica 88:134-47. 2003
    ..resistance protein (MRP), are thought to contribute to treatment failure, while it is unknown whether breast cancer resistance protein (BCRP) does so...
  77. ncbi Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer
    Kiyotaka Yoh
    Pathology Division, National Cancer Center Research Institute East, Chiba, Japan
    Clin Cancer Res 10:1691-7. 2004
    ..The purpose of this study was to investigate the relationship between the level of expression of ATP-binding cassette (ABC) transporter proteins, and response to chemotherapy and prognosis in advanced non-small cell lung cancer (NSCLC)...
  78. ncbi ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases
    Laurent Candeil
    CNRS UMR 5160, Centre de Recherche en Cancerologie, CRLC Val d Aurelle, Montpellier, France
    Int J Cancer 109:848-54. 2004
    ..The aim of the present study was to determine the involvement of ABCG2 in resistance to SN38 (the active metabolite of irinotecan) in colorectal cancer...
  79. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    Our studies demonstrate that the ABC transporter and marker of stem and progenitor cells known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival advantage under hypoxic conditions...
  80. ncbi Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta
    Daisuke Kobayashi
    Department of Hospital Pharmacy, Faculty of Medicine, Tottori University, Nishi machi 36 1, Yonago, 683 8504, Japan
    Drug Metab Dispos 33:94-101. 2005
    The aim of the present study was to assess the contribution of polymorphisms in the breast cancer resistance protein/ATP-binding cassette transporter G2 (BCRP/ABCG2) gene to the placental expression from a new perspective, allelic ..
  81. ncbi Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface
    Csilla Ozvegy-Laczka
    National Medical Center, Institute of Haematology and Immunology, Membrane Research Group and Hungarian Academy of Sciences, 1113 Budapest, Hungary
    J Biol Chem 280:4219-27. 2005
    The human ABCG2 protein is an important primary active transporter for hydrophobic compounds in several cell types, and its overexpression causes multidrug resistance in tumors...
  82. ncbi Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition
    Csilla Ozvegy-Laczka
    National Medical Center, Institute of Haematology and Immunology, Membrane Research Group of the Hungarian Academy of Sciences, Diószegi ut 64, H 1113 Budapest, Hungary
    Biochim Biophys Acta 1668:53-63. 2005
    The human ABCG2 protein is an ATP binding cassette half-transporter, which protects our cells and tissues against various xenobiotics, while overexpression of ABCG2 in tumor cells confers multidrug resistance...
  83. ncbi Single nucleotide polymorphisms modify the transporter activity of ABCG2
    Kuniaki Morisaki
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bldg 10 Rm 12C103, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 56:161-72. 2005
    Single nucleotide polymorphism (SNP) analyses of the ABCG2 gene have revealed three nonsynonymous SNPs resulting in the amino acid changes at V12M, Q141K and D620N...
  84. ncbi Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic
    Lubna Patrawala
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 65:6207-19. 2005
    ..Because the side population phenotype is mainly mediated by ABCG2, an ATP-binding cassette half-transporter associated with multidrug resistance, we subsequently studied ABCG2+ and ..
  85. ncbi Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics
    Yoshikazu Sugimoto
    Department of Chemotherapy, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cancer Sci 96:457-65. 2005
    b>Breast cancer resistance protein (BCRP) is a half-molecule ATP-binding cassette transporter that forms a functional homodimer and pumps out various anticancer agents, such as 7-ethyl-10-hydroxycamptothecin, topotecan, mitoxantrone and ..
  86. ncbi Role of ABCG2/BCRP in biology and medicine
    P Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Annu Rev Pharmacol Toxicol 46:381-410. 2006
    The protein variously named ABCG2/BCRP/MXR/ABCP is a recently described ATP-binding cassette (ABC) transporter originally identified by its ability to confer drug resistance that is independent of Mrp1 (multidrug-resistance protein 1) ..
  87. ncbi Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression
    Takeo Nakanishi
    Program in Experimental Therapeutics, University of Maryland Marlene and Stewart Greenebaum Cancer Center UMGCC, Baltimore, 21201, USA
    Blood 108:678-84. 2006
    Imatinib, a potent tyrosine kinase inhibitor, is effluxed from cells by the breast cancer resistance protein (BCRP/ABCG2), yet published studies to date fail to demonstrate resistance to imatinib cytotoxicity in BCRP-overexpressing cells ..
  88. ncbi The prognostic value of P-glycoprotein (ABCB) and breast cancer resistance protein (ABCG2) in adults with de novo acute myeloid leukemia with normal karyotype
    Daniela Damiani
    Division of Hematology and Bone Marrow Transplantation, Udine University Hospital, Udine, Italy
    Haematologica 91:825-8. 2006
    ..P-glycoprotein (PGP) over-expression has an unfavorable prognostic significance, while the role of breast cancer resistance protein (BCRP) is less clear, especially in AML patients with a normal karyotype...
  89. ncbi cGMP transport by vesicles from human and mouse erythrocytes
    Cornelia J F De Wolf
    Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    FEBS J 274:439-50. 2007
    ..by the ABCC4-specific substrate prostaglandin E1, cGMP transport into mouse vesicles was inhibited equally by Abcg2 and Abcc4 inhibitors/substrates...
  90. ncbi Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2
    Ai Tamura
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Cancer Sci 98:231-9. 2007
    Impacts of genetic polymorphisms of the ATP-binding cassette (ABC) transporter BCRP/MXR1/ABCP (ABCG2) on drug response have been implicated; however, the hitherto reported data involve some inconsistencies...
  91. ncbi Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients
    Jing Li
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Cancer Biol Ther 6:432-8. 2007
    ..EGFR) tyrosine kinase inhibitors (TKIs), gefitinib and erlotinib, are substrates for the efflux transporter ABCG2, and to investigate the relevance of the ABCG2 421C>A (Q141K) polymorphism to the pharmacokinetics of gefitinib...
  92. ncbi ABCG2: determining its relevance in clinical drug resistance
    Robert W Robey
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Metastasis Rev 26:39-57. 2007
    ..three human ABC transporters primarily associated with the multidrug resistance phenomenon, namely Pgp, MRP1, and ABCG2. All three have broad and, to a certain extent, overlapping substrate specificities, transporting the major drugs ..
  93. ncbi ATP-binding cassette transporter ABCG2 (BCRP) and ABCB1 (MDR1) variants are not associated with disease susceptibility, disease phenotype response to medical therapy or need for surgeryin Hungarian patients with inflammatory bowel diseases
    Simon Fischer
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Scand J Gastroenterol 42:726-33. 2007
    ..Since limited data are available on MDR1 and ABCG2 polymorphisms in East European IBD patients, the aim of this study was to investigate ABCG2 and MDR1 variants and ..
  94. ncbi Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells
    C Brendel
    Department of Hematology, Oncology and Immunology, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Leukemia 21:1267-75. 2007
    ..The ATP binding-cassette transporters ABCB1 (MDR-1; P-glycoprotein) and ABCG2 are highly expressed on primitive hematopoietic stem cells (HSCs) and have been shown to interact with TKIs...
  95. ncbi The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction
    Denis A Evseenko
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    FASEB J 21:3592-605. 2007
    The efflux pump ATP binding cassette superfamily member G2 (ABCG2)/breast cancer resistance protein (BCRP) is highly expressed in human placenta...
  96. doi Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups
    Phillip Müller
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, Heidelberg, Germany
    Leuk Res 32:919-29. 2008
    ..We analyzed: ABCC3 (MRP3) C-211T; ABCG2 (BCRP) C421A; CNT1 (SLC28A1) G565A and NAT1, NAT2, and GSTT1 and GSTM1 null alleles for influence on ..
  97. doi Homology modeling of breast cancer resistance protein (ABCG2)
    Eszter Hazai
    Virtua Drug, Ltd, H 1015 Budapest, Csalogány Street 4, Hungary
    J Struct Biol 162:63-74. 2008
    BCRP (also known as ABCG2, MXR, and ABC-P) is a member of the ABC family that transports a wide variety of substrates. BCRP is known to play a key role as a xenobiotic transporter...
  98. ncbi ABCG2: structure, function and role in drug response
    Orsolya Polgar
    National Cancer Institute, Medical Oncology Branch, Center for Cancer Research, NIH, 9000 Rockville Pike, Building 10, Room 13N240, Bethesda, MD 20892, USA
    Expert Opin Drug Metab Toxicol 4:1-15. 2008
    b>ABCG2 was discovered in multi-drug-resistant cancer cells, with the identification of chemotherapeutic agents, such as mitoxantrone, flavopiridol, methotrexate and irinotecan as substrates...
  99. pmc Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe
    Bradley L Urquhart
    Division of Clinical Pharmacology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    Pharmacogenet Genomics 18:439-48. 2008
    b>Breast cancer resistance protein (BCRP) is an efflux transporter expressed in tissues that act as barriers to drug entry...
  100. doi Pharmacogenomic importance of ABCG2
    George Cusatis
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Pharmacogenomics 9:1005-9. 2008
    The ATP-binding cassette transporter ABCG2 (BCRP, MXR and ABCP) is highly expressed in the gastrointestinal tract and liver, and governs absorption, distribution and excretion of a wide variety of clinically important drugs...
  101. doi A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Mutat Res 645:56-60. 2008
    ..b>ABCG2/BCRP is abundantly expressed in epithelial cells of the intestine and colon...

Research Grants70

  1. ABC Transporters in CNS Penetration of Camptothecins
    Christopher Waters; Fiscal Year: 2007
    ..by drug efflux transporters, including P-pg, multi-drug resistance protein 4 (MRP4), and the breast cancer resistance protein (BCRP or ABCG2). We seek to understand how drug distribution is controlled at the BBB and the BCB...
  2. Medications Development for the Pregnant Opiate Addict
    Mahmoud S Ahmed; Fiscal Year: 2010
    ..allosteric substrates on the activity of CYP19 and P-gp as well as the role of the efflux transporter breast cancer resistance protein (BCRP) on the bio-disposition of BUP and methadone during pregnancy...
  3. JOHN DAVID CASTLE; Fiscal Year: 2015
    ..Third, using isolated insulin granule fractions, fluorescent lipid analogs will be employed to assay ABC transporter and related lipid translocation mechanisms that are thought to contribute to insulin granule formation...
  4. ABCs of Cholesterol Regulation in the Insulin Secretory Pathway
    JOHN DAVID CASTLE; Fiscal Year: 2011
    ..Third, using isolated insulin granule fractions, fluorescent lipid analogs will be employed to assay ABC transporter and related lipid translocation mechanisms that are thought to contribute to insulin granule formation...
  5. Structure and Mechanism of Maltose Transport
    Jue Chen; Fiscal Year: 2009
    ..Because all members of the ABC transporter superfamily share sequence similarity and a common domain organization, these experiments will advance our ..
  6. Hight Throughput Screening for inhibitors of the ABC transporter ABCB6
    Partha C Krishnamurthy; Fiscal Year: 2012
    ....
  7. Davide Trotti; Fiscal Year: 2015
    ..e. P-glycoprotein or P-gp, Multi-drug resistance proteins or MRPs, breast cancer resistance protein or BCRP, a.k.a. ABCG2) at the blood brain barrier (BBB) and blood cerebrospinal fluid (BCSF) barrier...
  8. Functions of MRP2 and MRP3 in Drug Disposition
    James M Gallo; Fiscal Year: 2011
    ..P-glycoprotein (PGP), an ABC transporter that functions as a plasma membrane efflux pump, is an established factor that limits oral bioavailability, ..
  9. THOMAS PAUL DAVIS; Fiscal Year: 2014
    ..e., P-glycoprotein (P-gp), Multidrug Resistance Proteins (Mrps), Breast Cancer Resistance Protein (BCRP;also known as ABCG2), organic anion transporting polypeptides (Oatps)) and/or tight junction ..
  10. Tatiana Nanovskaya; Fiscal Year: 2015
    ..reductases), as well as its efflux transporters P-glycoprotein (P-gp) and Breast Cancer Resistant Protein (BCRP), have an important role in regulating placental disposition of bupropion and, consequently, fetal exposure to the ..
  11. John R Ohlfest; Fiscal Year: 2014
    ..cells overexpress protective active efflux transport systems, including p-glycoprotein (Pgp) and breast cancer resistance protein (BCRP)...
  12. Michal Toborek; Fiscal Year: 2015
    ..end products (RAGE) and alterations of ABC efflux transporters (namely, P-glycoprotein [Pgp] and breast cancer resistance protein [BCRP]), may be involved in these processes...
  13. Mechanisms By Which Maternal And Fetal Drug Exposure Is*
    Jashvant Unadkat; Fiscal Year: 2006
    ..drug transport in both the Intestine and the placenta, namely P-glycoprotein (P-gp; Project 1), the Breast Cancer Resistance Protein (BCRP; Project 2), and the Organic Cation Transporter 3 (OCT3; Project 3)...
  14. P-glycoprotein Function in Allograft Rejection
    Markus Frank; Fiscal Year: 2004
    ..thrust of his research has been the study of the role of P-glycoprotein, the multidrug resistance-associated ABC transporter, in alloimmunity, and the principle findings are now being published in the Journal of Immunology...
  15. Targeting MRP7 to Overcome Drug Resistance for Ovarian Cancer Therapy by Taxanes
    Zhe Sheng Chen; Fiscal Year: 2010
    ..P-glycoprotein, an ABC transporter, is one of the major factors that produce resistance to paclitaxel...
  16. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus H Frank; Fiscal Year: 2010
    ..ABCB5 P-glycoprotein is a novel ABC transporter, which mediates drug efflux in cancer cells and regulates cell fusion and resultant differentiation of ..
  17. Role of the ABC Transporter ABCB6 in Cytotoxicity
    John Schuetz; Fiscal Year: 2006
    ..During this grant cycle we identified a mitochondria! ABC transporter that was increased in rat liver tumors, initially referred to as PRP for P-glycoprotein related p/otein...
  18. Sangeeta Ray; Fiscal Year: 2015
    ..The ABCG2 multi- drug resistance pump has become an important target in efforts to overcome chemotherapy resistance...
  19. The Role of Signaling Pathways in Brain Tumors in Mice
    Eric C Holland; Fiscal Year: 2013
    ..Multi-drug resistance in these tumors is primarily due to activity of ABCG2 (a CNS stem cell marker), and is linked to the resistance of these tumors to chemotherapy...
  20. ABC TRANSPORTERS AND PATHOGENECITY OF CANDIDA ALBICANS
    GERWALD KOHLER; Fiscal Year: 2004
    ..Multiple drug resistance and many human hereditary diseases have been related to ABC transporter function, however, the physiological roles of only a few of these transporters have been elucidated...
  21. ABC Transporters as Pharmaceutical Targets
    Brian West; Fiscal Year: 2003
    ABC transporters pump a variety of small molecules and peptides across cell membranes. Mutations in ABC transporter genes cause severe defects in man...
  22. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..procedure that is based on the ability of primitive progenitor cells to efflux a Hoechst dye via an ABCG2 transporter which is common to adult stem cells, termed the side population (SP)...
  23. Beth A McCormick; Fiscal Year: 2016
    ..an efflux transport system located at the apical surface of the intestinal epithelia that involves the ABC transporter MRP2...
  24. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2012
    ..which we have shown is lipid modified and exported by the somatic gonad cells by an conserved, unconventional ABC transporter. Mis-migration of germ cells in humans is thought to be the cause of germinomas, tumors of the germ line that ..
  25. Timothy F Murphy; Fiscal Year: 2016
    ..catarrhalis infections. We identified oligopeptide permease A (OppA), a solute binding protein of an ABC transporter system, as a promising vaccine antigen and also as a potential virulence factor. M...
  26. LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIA
    Pei Zhou; Fiscal Year: 2012
    ..core oligosaccharide, the core-lipid A complex is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached...
  27. Ruth Lehmann; Fiscal Year: 2016
    ..which we have shown is lipid modified and exported by the somatic gonad cells by an conserved, unconventional ABC transporter. Mis-migration of germ cells in humans is thought to be the cause of germinomas, tumors of the germ line that ..
  28. ANALYSIS OF A NOVEL SUBSET OF HUMAN CD8+ MEMORY CELLS WITH STEM CELL QUALITIES
    Stanley R Riddell; Fiscal Year: 2010
    ..The potential impact of this work relates to improving our understanding of the mechanisms responsible for the durability of human CD8+ T memory in normal individuals and those undergoing chemotherapy or vaccination. ..
  29. Carlos Fernandez Hernando; Fiscal Year: 2016
    ....
  30. BIOSYNTHESIS AND FUNCTION OF LIPOPOLYSACCHARIDES
    Pei Zhou; Fiscal Year: 2013
    ..core oligosaccharide, the core-lipid A complex is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached...
  31. Spin labeling of MsbA
    Candice S Klug; Fiscal Year: 2012
    ..Specifically, MsbA is the ABC transporter for lipid A that is found in the inner membranes of Gram-negative bacteria such as Escherichia coli, ..
  32. Ming Hu; Fiscal Year: 2016
    ..e., sulfotransferases and UDP-glucuronosyltransferases) and efflux transporters (e.g., BCRP and MRP2)...
  33. W Scott Moye-Rowley; Fiscal Year: 2016
    ..directly analogous to multidrug resistance in mammalian cells as both can be triggered by elevated levels of ABC transporter proteins (ScPdr5 in S. cerevisiae) that efflux drugs out of the cell...
  34. Adaptive glutathione responses to cigarette smoke in COPD
    Brian J Day; Fiscal Year: 2011
    ..The cystic fibrosis transmembrane conductance regulator (CFTR) and breast cancer related protein (BCRP) congenic KO mouse provides a unique animal models to study defective lung GSH efflux, oxidative stress, ..
  35. JURGEN T ROHR; Fiscal Year: 2016
    ..In addition, another NCI group found in June 2012 that MTM represses cigarette smoke induced ABCG2 efflux pumps responsible for the drug resistance of lung and esophageal cancers, and inhibited multiple stem-cell ..
  36. Mary G Sorci-Thomas; Fiscal Year: 2015
    ..Development of these novel assays will make it possible, for the first time, to perform large clinical studies to fully test the idea that dysfunctional HDL is better indicator of atherosclerotic risk. ..
  37. Bhaumik B Patel; Fiscal Year: 2016
    ..Lastly, we will delineate the role of specific miR-215 (TS and ABCG2) as well as miR-363 (CD51 and MCL-1) target genes in modulating CSC phenotype (Aim 3)...
  38. ABC-transporter binding proteins and trafficking
    Daniel F Ortiz; Fiscal Year: 2010
    ..abstract_text> ..
  39. Elizabeth A Miller; Fiscal Year: 2015
    ..problem using a combination of genetic and biochemical approaches, focusing on the biogenesis of the yeast ABC transporter, Yor1p, a drug pump that confers resistance to the toxin, oligomycin...
  40. Show Ling Shyng; Fiscal Year: 2016
    ..2 with a sulfonylurea receptor (SUR), an ABC transporter, for functional expression. In pancreatic [unreadable]- cells, KATP channels formed by Kir6...
  41. KATSONURI SUGIMOTO; Fiscal Year: 2015
    ..ATM/Tel1 localizes to DSBs by interacting Mre11-Rad50-Nbs1/Xrs2 (MRN/MRX) complex...
  42. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2009
    ..following specific aims are proposed: 1) To generate new mouse models capable of inducibly expressing molecules in Bcrp1+ mammary side-population (SP) cells, and to determine the impact of oncogenic signaling pathways on SP ceils, and ..
  43. MRP4 IN DRUG SENSITIVITY AND PHYSIOLOGY
    John D Schuetz; Fiscal Year: 2012
    ..over the last funding period were directed to elucidating the function and molecular regulation of the ABC transporter, Mrp4...
  44. Peng George Wang; Fiscal Year: 2016
    ....
  45. Jashvant D Unadkat; Fiscal Year: 2016
    ..and licit drugs in the liver or the placenta, namely CYP3A (Project 1), CYP2B6 and CYP2D6 (Project 2), P-gp and BCRP (Project 3), and OCTS, NET, and SERT (Project 4)...
  46. Mechanisms and Binding-Sites in Adenylate Kinase-Dependent CFTR Gating
    CHRISTOPH OSKAR RANDAK; Fiscal Year: 2013
    ..Because CFTR is an ABC transporter, this knowledge may also impact treatments of other ABC transporter-related diseases. (End of Abstract)
  47. TOPOISOMERASE I INHIBITORS IN LEUKEMIA AND SOLID TUMORS
    Scott H Kaufmann; Fiscal Year: 2010
    ..receptor tyrosine kinase inhibitor OSI-774 (based on the ability of OSI-774 to inhibit efflux of SN-38 by the ABCG2 transporter) and with the heat shock protein 90 (Hsp90) inhibitor 17-allylamino-17-demethoxy- geldanamycin...
  48. Modeling proteostatic deficiencies in CFTR
    Beverly H Koller; Fiscal Year: 2012
    ..In this application we propose to develop models that will not only test the feasibility of this approach, but that can also be used for the rapid screening for such therapeutic agents. ..
  49. Impact of Pregnancy Disease on the Regulation of Placenta Drug Transport
    Clifford W Mason; Fiscal Year: 2013
    ..there is up- regulation of the drug efflux transporters, multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), in the placenta of women with infection and associated chorioamnionitis...
  50. Targeting the oligomerization of human ABCG2
    Jian Ting Zhang; Fiscal Year: 2009
    ..have been identified: P-glycoprotein (Pgp), multidrug resistance-associated proteinl (MRP1), and breast cancer resistance protein/mitoxantrone resistance protein (BCRP/MXR)...
  51. Mechanism of Drug Transport by BCRP/ABCG2
    Qingcheng Mao; Fiscal Year: 2010
    The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is a medically important ABC drug transporter...
  52. The role of MRP1 in Protection of Cardiac Injury
    Mary Vore; Fiscal Year: 2012
    ....
  53. Alan E Tomkinson; Fiscal Year: 2014
    ..studies with yeast NHEJ factors have revealed functional interactions among yKu70/yKu80 (yKu), Mre11/Rad50/Xrs2 (MRX) and Dnl4/Lif1 complexes and defined how these factors are recruited to in vivo DNA double strand breaks...
  54. Roles of Phosphate Uptake in Pneumococcal Antibiotic Resistance and Virulence
    Malcolm E Winkler; Fiscal Year: 2013
    ..Four Specific Aims will be met by this grant. Aim 1 will determine whether two predicted Pi ABC transporter pumps (designated as Pst1 and Pst2) separately uptake Pi in S...
  55. Molly A Hughes; Fiscal Year: 2016
    ..and found that disruption of ftsX, which encodes the transmembrane protein of a widely conserved prokaryotic ABC transporter, resulted in a CXCL10-resistant phenotype. Deletion of the ftsX gene in B. anthracis (i.e...
  56. Development of Bupropion for Smoking Cessation During Pregnancy
    Tatiana Nanovskaya; Fiscal Year: 2011
    ..The role of placental efflux transporters P-gp and BCRP in determining the concentration of bupropion and hydroxybupropion in the fetal circulation;4...
  57. Simon Petersen-Jones; Fiscal Year: 2016
    ..Third, we will purify ABCA4, the photoreceptor-specific ABC transporter that prevents accumulation of the toxic compounds, all- trans-retinal and its derivatives, including N-..
  58. MRP2, BSEP, and BCRP Transporter Polymorphisms and Chemotherapy Disposition
    RICHARD HSINSHIN HO; Fiscal Year: 2011
    ..goal of this proposal is to establish the associations between functional polymorphisms in MRP2, BSEP, and BCRP drug efflux transporters and modulation of chemotherapeutic disposition...
  59. Biosynthesis and function of ABC transporters
    Patrick H Thibodeau; Fiscal Year: 2010
    ..abstract_text> ..
  60. Molecular Mechanisms of Active Transport Across Cellular Membranes
    Emad Tajkhorshid; Fiscal Year: 2013
    ..we propose projects investigating three active membrane transporters: (1) Maltose transporter, an ABC transporter in which ATP binding and hydrolysis drive the process of substrate transport;(2) Glutamate transporter (GluT),..
  61. Mechanisms of PEN protein focal accumulation and regulation in plant immunity.
    WILLIAM R UNDERWOOD; Fiscal Year: 2010
    ..Both PEN1, a syntaxin, and PENS, an ABC transporter, contribute to penetration resistance in Arabidopsis and are recruited to sites of interaction with the ..
  62. Improving Rate/Quality Limitations in Membrane Protein Structure Determination
    William A Cramer; Fiscal Year: 2010
    ..selected, with an emphasis on ABC and hetero-oligomeric proteins;(i) ABC: maltose and ribose transporters, ABCBl, ABCG2, and Sur-Kir6.2;(ii) non-ABC: twin-arginine translocase;Kdp-ATPase;NADH dehydrogenase...
  63. STRUCTURE AND FUNCTION OF HYALURONAN SYNTHASES
    Paul H Weigel; Fiscal Year: 2012
    ..g. to alter HA activity, HA size or cellular localization) that might be drug candidates for clinical applications, particularly in cancer, metastasis, and streptococcal diseases. ..
  64. Genetics and biosynthesis of an O antigen essential for symbiosis
    KENNETH D NOEL; Fiscal Year: 2010
    ..and biologically) in which the O-antigen portion of the LPS is synthesized by a mechanism dependent on an ABC transporter encoded by wzm and wzt genes...
  65. Benzo[i]phenanthridines: TOP1-Targeting Antitumor Agents
    EDMOND LAVOIE; Fiscal Year: 2006
    ..novel TOP1-targeting agents capable of overcoming multidrug resistance associated with efflux transporters such as BCRP, as well as MDR1 (P-glycoprotein), MRP1, and LRP; 2) to assess in vivo efficacy using various human tumor cell ..
  66. HEPATIC DRUG ELIMINATION IN PREGNANCY
    Mary Vore; Fiscal Year: 2010
    This proposal focuses on the function and expression of MRP2 (ABCC2), the ABC transporter that mediates the biliary excretion of glucuronide and glutathione conjugates from the hepatocyte into bile...
  67. HEPATIC DRUG ELIMINATION IN PREGNANCY
    Mary Vore; Fiscal Year: 2007
    ..provided by applicant): This proposal focuses on the function and expression of MRP2 (ABCC2), the ABC transporter that mediates the biliary excretion of glucuronide and glutathione conjugates from the hepatocyte into bile...
  68. CRYSTALLIZATION OF AN ABC TRANSPORTER
    BING JAP; Fiscal Year: 1999
    ..This structure should reveal general principles governing the molecular mechanisms of members of the ABC superfamily, and provide insight into the structural basis of diseases associated with defects in the transporters. ..

Patents1

  1. Method for predicting a drug transport capability by abcg2 polymorphisms
    Patent Number: WO03107249-A1; Date:2003-12-24