ABL2

Summary

Gene Symbol: ABL2
Description: ABL proto-oncogene 2, non-receptor tyrosine kinase
Alias: ABLL, ARG, tyrosine-protein kinase ABL2, Abelson tyrosine-protein kinase 2, abelson-related gene protein, c-abl oncogene 2, non-receptor tyrosine kinase, tyrosine-protein kinase ARG, v-abl Abelson murine leukemia viral oncogene homolog 2
Species: human
Products:     ABL2

Top Publications

  1. Chen W, Kung H, Yang W, Lin W. Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. Int J Cancer. 1999;83:579-84 pubmed
    ..kinases expressed in these tissues: they include 10 non-receptor tyrosine kinases (yes, fyn, lyn, brk, abl, arg, jak1, jak3, tyk2 and itk), 17 receptor tyrosine kinases (erbB2, PDGF-Ralpha, PDGF-Rbeta, kit, c-fms, met, ron, FGF-..
  2. Tanis K, Veach D, Duewel H, Bornmann W, Koleske A. Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol Cell Biol. 2003;23:3884-96 pubmed
    The activities of the related Abl and Arg nonreceptor tyrosine kinases are kept under tight control in cells, but exposure to several different stimuli results in a two- to fivefold stimulation of kinase activity...
  3. Srinivasan D, Kaetzel D, Plattner R. Reciprocal regulation of Abl and receptor tyrosine kinases. Cell Signal. 2009;21:1143-50 pubmed publisher
    Previously, we showed that Abl kinases (c-Abl, Arg) are activated downstream of PDGF in a manner dependent on Src kinases and PLC-gamma1, and promote PDGF-mediated proliferation and migration of fibroblasts...
  4. Cazzaniga G, Tosi S, Aloisi A, Giudici G, Daniotti M, Pioltelli P, et al. The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. Blood. 1999;94:4370-3 pubmed
    ..reaction (3'RACE-PCR), a novel fusion transcript was identified between the ETV6 and the Abelson-related gene (ARG) at 1q25, resulting in a chimeric protein consisting of the HLH oligomerization domain of ETV6 and the SH2, SH3, ..
  5. Iijima Y, Ito T, Oikawa T, Eguchi M, Eguchi Ishimae M, Kamada N, et al. A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation. Blood. 2000;95:2126-31 pubmed
    ..We identified a novel ETV6 partner gene, ARG (ABL-related gene or ABL2), another TK gene in a cell line established from a patient with acute myelogenous leukemia (AML-M3) with a t(15;17)..
  6. Pendergast A. The Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res. 2002;85:51-100 pubmed
  7. Mader C, Oser M, Magalhaes M, Bravo Cordero J, Condeelis J, Koleske A, et al. An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res. 2011;71:1730-41 pubmed publisher
    ..In this study, we provide evidence that the Abl-related nonreceptor tyrosine kinase Arg mediates epidermal growth factor (EGF)-induced cortactin phosphorylation, triggering actin polymerization in ..
  8. Ganguly S, Fiore L, Sims J, Friend J, Srinivasan D, Thacker M, et al. c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression. Oncogene. 2012;31:1804-16 pubmed publisher
    ..Here, we found a previously unrecognized role for c-Abl and Arg in melanoma progression...
  9. Ma Q, Wang J, Liu X, Yang Y, Zhao H, Wang Y, et al. c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3. Cell Death Differ. 2010;17:1277-87 pubmed publisher
    ..This study shows that c-Abl and Abl-related gene (Arg) associate with and phosphorylate Gal3...
  10. Martfeld A, Greathouse D, Koeppe R. Ionization Properties of Histidine Residues in the Lipid Bilayer Membrane Environment. J Biol Chem. 2016;291:19146-56 pubmed publisher
    ..The combined results enable us to compare the ionization properties of lipid-exposed His, Lys, and Arg side chains in lipid bilayer membranes.

Detail Information

Publications62

  1. Chen W, Kung H, Yang W, Lin W. Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. Int J Cancer. 1999;83:579-84 pubmed
    ..kinases expressed in these tissues: they include 10 non-receptor tyrosine kinases (yes, fyn, lyn, brk, abl, arg, jak1, jak3, tyk2 and itk), 17 receptor tyrosine kinases (erbB2, PDGF-Ralpha, PDGF-Rbeta, kit, c-fms, met, ron, FGF-..
  2. Tanis K, Veach D, Duewel H, Bornmann W, Koleske A. Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol Cell Biol. 2003;23:3884-96 pubmed
    The activities of the related Abl and Arg nonreceptor tyrosine kinases are kept under tight control in cells, but exposure to several different stimuli results in a two- to fivefold stimulation of kinase activity...
  3. Srinivasan D, Kaetzel D, Plattner R. Reciprocal regulation of Abl and receptor tyrosine kinases. Cell Signal. 2009;21:1143-50 pubmed publisher
    Previously, we showed that Abl kinases (c-Abl, Arg) are activated downstream of PDGF in a manner dependent on Src kinases and PLC-gamma1, and promote PDGF-mediated proliferation and migration of fibroblasts...
  4. Cazzaniga G, Tosi S, Aloisi A, Giudici G, Daniotti M, Pioltelli P, et al. The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. Blood. 1999;94:4370-3 pubmed
    ..reaction (3'RACE-PCR), a novel fusion transcript was identified between the ETV6 and the Abelson-related gene (ARG) at 1q25, resulting in a chimeric protein consisting of the HLH oligomerization domain of ETV6 and the SH2, SH3, ..
  5. Iijima Y, Ito T, Oikawa T, Eguchi M, Eguchi Ishimae M, Kamada N, et al. A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation. Blood. 2000;95:2126-31 pubmed
    ..We identified a novel ETV6 partner gene, ARG (ABL-related gene or ABL2), another TK gene in a cell line established from a patient with acute myelogenous leukemia (AML-M3) with a t(15;17)..
  6. Pendergast A. The Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res. 2002;85:51-100 pubmed
  7. Mader C, Oser M, Magalhaes M, Bravo Cordero J, Condeelis J, Koleske A, et al. An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res. 2011;71:1730-41 pubmed publisher
    ..In this study, we provide evidence that the Abl-related nonreceptor tyrosine kinase Arg mediates epidermal growth factor (EGF)-induced cortactin phosphorylation, triggering actin polymerization in ..
  8. Ganguly S, Fiore L, Sims J, Friend J, Srinivasan D, Thacker M, et al. c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression. Oncogene. 2012;31:1804-16 pubmed publisher
    ..Here, we found a previously unrecognized role for c-Abl and Arg in melanoma progression...
  9. Ma Q, Wang J, Liu X, Yang Y, Zhao H, Wang Y, et al. c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3. Cell Death Differ. 2010;17:1277-87 pubmed publisher
    ..This study shows that c-Abl and Abl-related gene (Arg) associate with and phosphorylate Gal3...
  10. Martfeld A, Greathouse D, Koeppe R. Ionization Properties of Histidine Residues in the Lipid Bilayer Membrane Environment. J Biol Chem. 2016;291:19146-56 pubmed publisher
    ..The combined results enable us to compare the ionization properties of lipid-exposed His, Lys, and Arg side chains in lipid bilayer membranes.
  11. Wu D, Huang X, Sun J, Graham D, Xie B. Antibiotic Resistance Genes and Associated Microbial Community Conditions in Aging Landfill Systems. Environ Sci Technol. 2017;51:12859-12867 pubmed publisher
    ..Antibiotics levels were consistently lower in refuse and leachates from older landfills, whereas ARG levels in leachates significantly increased with landfill age (One-way ANOVA, F = 10.8, P < 0.01)...
  12. Li L, Duan C, Zhao Y, Zhang X, Yin H, Wang T, et al. Preventive effects of interleukin-6 in lipopolysaccharide/d-galactosamine induced acute liver injury via regulating inflammatory response in hepatic macrophages. Int Immunopharmacol. 2017;51:99-106 pubmed publisher
    ..and chemokines, TNF-α, RANTES and MCP-1 in macrophages while promoting the expression of M2 markers, such as Arg-1 and Mrc-1 in macrophages...
  13. Torsello B, Bianchi C, Meregalli C, Di Stefano V, Invernizzi L, De Marco S, et al. Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions. J Cell Sci. 2016;129:2925-36 pubmed publisher
    ..Our study investigated the involvement of non-receptor tyrosine kinase Arg (also called Abl2) in TGF-β production. Human primary tubular cell cultures exposed to high-glucose conditions were used...
  14. Ivanova T, Hardes K, Kallis S, Dahms S, Than M, Künzel S, et al. Optimization of Substrate-Analogue Furin Inhibitors. ChemMedChem. 2017;: pubmed publisher
    ..compounds; the highest potency was found for our previously developed inhibitor 4-(guanidinomethyl)phenylacetyl-Arg-Tle-Arg-4-amidinobenzylamide (MI-1148)...
  15. Obayashi E, Luna R, Nagata T, Martin Marcos P, Hiraishi H, Singh C, et al. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017;18:2651-2663 pubmed publisher
    ..3c1 contacts eIF1 through Arg-53 and Leu-96, while 3c2 faces 40S protein uS15/S13, to anchor eIF1 to the scanning pre-initiation complex (PIC)...
  16. Wang H, Cui J, Zheng Z, Shi Q, Sun T, Liu X, et al. Assembly of RGD-Modified Hydrogel Micromodules into Permeable Three-Dimensional Hollow Microtissues Mimicking in Vivo Tissue Structures. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..hollow micromodules are prepared by photocopolymerizing poly(ethylene glycol) diacrylate (PEGDA) with acryloyl-PEG-Arg-Gly-Asp-Ser (RGDS)...
  17. Naranjo A, Isenring E, Teleni L. Immune-Enhancing Formulas for Patients With Cancer Undergoing Esophagectomy: Systematic Review Protocol. JMIR Res Protoc. 2017;6:e214 pubmed publisher
    ..there is a growing need for clinicians to know whether use of immune-enhancing formulas (IEFs) containing Arg, omega-3, and RNA are a cost-effective approach compared with isonitrogenous-isocaloric formulas to reduce ..
  18. Wang H, Barbieri C, He J, Gao Y, Shi T, Wu C, et al. Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics. J Transl Med. 2017;15:175 pubmed publisher
    ..Despite inherent limitations due to amino acid sequence constraints, all the PRISM-SRM assays developed using Arg-C digestion showed a linear dynamic range of at least two orders of magnitude, with limits of quantification ranged ..
  19. Dubielecka P, Machida K, Xiong X, Hossain S, Ogiue Ikeda M, Carrera A, et al. Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. FEBS Lett. 2010;584:3279-86 pubmed publisher
    ....
  20. Gjorevski N, Lutolf M. Synthesis and characterization of well-defined hydrogel matrices and their application to intestinal stem cell and organoid culture. Nat Protoc. 2017;12:2263-2274 pubmed publisher
    ..comprise a poly(ethylene glycol) (PEG) hydrogel backbone functionalized with minimal adhesion cues including RGD (Arg-Gly-Asp), which is sufficient for ISC expansion, and laminin-111, which is required for organoid formation...
  21. Gardina P, Conway C, Kossman M, Manson M. Aspartate and maltose-binding protein interact with adjacent sites in the Tar chemotactic signal transducer of Escherichia coli. J Bacteriol. 1992;174:1528-36 pubmed
    ..The Arg-64, Arg-69, and Arg-73 residues of Tar have previously been shown to be involved in aspartate sensing...
  22. Bryan R, Marrelli S, Steenberg M, Schildmeyer L, Johnson T. Effects of luminal shear stress on cerebral arteries and arterioles. Am J Physiol Heart Circ Physiol. 2001;280:H2011-22 pubmed
    ..After removal of the endothelium, the luminal application of a polypeptide containing the Arg-Gly-Asp amino acid sequence (inhibitor of integrin attachment) abolished the flow-induced constriction...
  23. Singh A, Singh N, Behera D, Sharma S. Association and multiple interaction analysis among five XRCC1 polymorphic variants in modulating lung cancer risk in North Indian population. DNA Repair (Amst). 2016;47:30-41 pubmed publisher
    ..Genotyping was done for the five non-synonymous and synonymous variants of XRCC1 i.e. XRCC1, Arg194Trp, Pro206Pro, Arg280His, Arg399Gln, Gln632Gln...
  24. Memmer S, Weil S, Beyer S, Zöller T, Peters E, Hartmann J, et al. The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex. J Biol Chem. 2016;291:25427-25438 pubmed
    ..Moreover, we propose that ligand binding triggers translocation of Arg-143 from the membrane interface into the membrane to enable alignment with oppositely charged aspartate residues ..
  25. Uhde I, Toman A, Gross I, Schwanstecher C, Schwanstecher M. Identification of the potassium channel opener site on sulfonylurea receptors. J Biol Chem. 1999;274:28079-82 pubmed
    ..By exchanging domains between SUR1 and SUR2B, we identify two regions (KCO I: Thr(1059)-Leu(1087) and KCO II: Arg(1218)-Asn(1320); rat SUR2 numbering) within the second set of transmembrane domains (TMDII) as critical for KCO ..
  26. Kara E, Manna D, Løset G, Schneider E, Craik C, Kanse S. Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thromb Haemost. 2017;117:1750-1760 pubmed publisher
    ..The representative FSAP-cleaved sequence obtained from the phage display method was Val-Leu-Lys-Arg-Ser (P4-P1'). The sequence X-Lys/Arg-Nle-Lys/Arg (P4-P1) was derived from the PS-SCL method...
  27. Wetzel D, Rhodes E, Li S, MCMAHON PRATT D, Koleske A. The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. J Cell Sci. 2016;129:3130-43 pubmed publisher
    ..We have previously shown that the Arg (also known as Abl2) non-receptor tyrosine kinase facilitates L. amazonensis amastigote uptake by macrophages...
  28. Wang Y, Zheng Y, Tu Z, Dai Y, Xu H, Lv L, et al. The anti-tumor effects of the recombinant toxin protein rLj-RGD3 from Lampetra japonica on pancreatic carcinoma Panc-1 cells in nude mice. Peptides. 2017;88:8-17 pubmed publisher
    Recombinant Lampetra japonica RGD peptide (rLj-RGD3) is a soluble toxin protein with three RGD (Arg-Gly-Asp) motifs and a molecular weight of 13.5kDa...
  29. Ganz T, Wainstein J, Gilad S, Limor R, Boaz M, Stern N. Serum asymmetric dimethylarginine and arginine levels predict microvascular and macrovascular complications in type 2 diabetes mellitus. Diabetes Metab Res Rev. 2017;33: pubmed publisher
    Increased oxidative stress in diabetes increases nitric oxide (NO) oxidation and low l-arginine (Arg) could further reduce NO and impair vascular function, thereby accelerating, in the long run, vascular complications...
  30. Oh S, Kim J, Kim Y, Lee M, Kook M, Choi E, et al. The extracellular matrix protein Edil3 stimulates osteoblast differentiation through the integrin α5β1/ERK/Runx2 pathway. PLoS ONE. 2017;12:e0188749 pubmed publisher
    ..growth factor-like repeats and discoidin I-like domain 3 (Edil3) is an extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif that binds integrin...
  31. Weinger J, Gohari P, Yan Y, Backer J, Varnum B, Shafit Zagardo B. In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. J Neurochem. 2008;106:134-46 pubmed publisher
    ....
  32. Démoulins T, Ebensen T, Schulze K, Englezou P, Pelliccia M, Guzman C, et al. Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure. J Control Release. 2017;266:256-271 pubmed publisher
    ..Inclusion of (Arg)9 or TAT(57-57) CPPs further modified the translation readouts, but varied for different gene ..
  33. Raksanoh V, Shank L, Prangkio P, Yentongchai M, Sakdee S, Imtong C, et al. Zn2+-dependent autocatalytic activity of the Bordetella pertussis CyaA-hemolysin. Biochem Biophys Res Commun. 2017;485:720-724 pubmed publisher
    ..Moreover, Arg997‒one of the identified cleavage sites of the CyaA-RTX fragment was located in close proximity to the ..
  34. Bueno I, Williams Nguyen J, Hwang H, Sargeant J, Nault A, Singer R. Systematic Review: Impact of point sources on antibiotic-resistant bacteria in the natural environment. Zoonoses Public Health. 2017;: pubmed publisher
    ..may have a role in the dissemination of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARG)...
  35. He Y, Wang Y, Zhao P, Rayaprolu S, Wang X, Cao X, et al. Serpin-9 and -13 regulate hemolymph proteases during immune responses of Manduca sexta. Insect Biochem Mol Biol. 2017;90:71-81 pubmed publisher
    ..Serpin-9 was cleaved at Arg366 by the enzymes with different specificity, but serpin-13 had four P1 sites (Arg410 for ..
  36. Nakagawa K, Nakagawa K, Omatsu T, Katayama Y, Oba M, Mitake H, et al. Generation of a novel live rabies vaccine strain with a high level of safety by introducing attenuating mutations in the nucleoprotein and glycoprotein. Vaccine. 2017;35:5622-5628 pubmed publisher
    The current live rabies vaccine SAG2 is attenuated by only one mutation (Arg-to-Glu) at position 333 in the glycoprotein (G333)...
  37. Jiang Y, Almannai M, Sutton V, Sun Q, Elsea S. Quantitation of phenylbutyrate metabolites by UPLC-MS/MS demonstrates inverse correlation of phenylacetate:phenylacetylglutamine ratio with plasma glutamine levels. Mol Genet Metab. 2017;: pubmed publisher
    ..deficiency (OTC), argininosuccinate lyase deficiency (ASL), citrullinemia type I (ASS1), and argininemia (ARG)...
  38. Peana M, Zdyb K, Medici S, Pelucelli A, Simula G, Gumienna Kontecka E, et al. Ni(II) interaction with a peptide model of the human TLR4 ectodomain. J Trace Elem Med Biol. 2017;44:151-160 pubmed publisher
    ..has been modified by the substitution of some selected lipophilic residues (Leu and Phe) with hydrophilic residues (Arg), aiming at increasing the peptide hydro solubility of the protein fragment...
  39. Dhandhukia J, Shi P, Peddi S, Li Z, Aluri S, Ju Y, et al. Bifunctional Elastin-like Polypeptide Nanoparticles Bind Rapamycin and Integrins and Suppress Tumor Growth in Vivo. Bioconjug Chem. 2017;28:2715-2728 pubmed publisher
    ..A new ELP nanoparticle (ISR) was synthesized that includes the canonical integrin-targeting ligand (Arg-Gly-Asp, RGD)...
  40. Fredriksson Lidman K, Van Itallie C, Tietgens A, Anderson J. Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. PLoS ONE. 2017;12:e0185448 pubmed publisher
    SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types...
  41. Ewida M, Abou El Ella D, Lasheen D, Ewida H, El Gazzar Y, El Subbagh H. Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study. Bioorg Chem. 2017;74:228-237 pubmed publisher
    ..Molecular modeling studies concluded that recognition with key amino acids Phe 31 and Arg 22 is essential for DHFR binding...
  42. Bugg T, Rodolis M, Mihalyi A, Jamshidi S. Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage ϕX174 lysis protein E, and cationic antibacterial peptides. Bioorg Med Chem. 2016;24:6340-6347 pubmed publisher
    ..have also identified a protein-protein interaction site in Escherichia coli MraY, that is targeted by bacteriophage ϕX174 lysis protein E, and also by cationic antimicrobial peptides containing Arg-Trp close to their N- or C-termini.
  43. de Oliveira A, de Almeida V, Gomes F, Rezaie A, Monteiro R. TR47, a PAR1-based peptide, inhibits melanoma cell migration in vitro and metastasis in vivo. Biochem Biophys Res Commun. 2018;495:1300-1304 pubmed publisher
    ..may be reproduced by TR47, a PAR1-based peptide that mimics the novel N-terminus of PAR1 generated upon cleavage at Arg-46 by APC...
  44. Li Y, Liao M, Zhou J. Catechol-cation adhesion on silica surfaces: molecular dynamics simulations. Phys Chem Chem Phys. 2017;19:29222-29231 pubmed publisher
    ..molecular dynamics simulations are employed to study the adhesion of siderophore analogues (Tren-Lys-Cam, Tren-Arg-Cam and Tren-His-Cam) on silica surfaces with different degrees of ionization and the effects of cationic amino ..
  45. Zhang H, Gannon L, Hassall K, Deery M, Gibbs D, Holdsworth M, et al. N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway. New Phytol. 2017;: pubmed publisher
    ..To investigate the impact of the Arg/N-end rule pathway on the proteome of etiolated seedlings, we used terminal amine isotopic labelling of substrates ..
  46. Reid J, Matsika A, Davies C, He Y, Broomfield A, Bennett N, et al. Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases. Am J Cancer Res. 2017;7:2257-2274 pubmed
    ..and cell surface proteins, demonstrates a network of interactions centred largely at the plasma membrane, with the Arg/Lys specific proteases hepsin and TMPRSS2 key regulators of the network...
  47. Aryanpour R, Pasbakhsh P, Zibara K, Namjoo Z, Beigi Boroujeni F, Shahbeigi S, et al. Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model. Int Immunopharmacol. 2017;51:131-139 pubmed publisher
    ..iNOS, CD86, MHC-II and TNF-α) in the corpus callosum region, whereas the expression of M2-markers (Trem-2, CD206, Arg-1 and TGF-β) was significantly increased, in comparison to CPZ mice...
  48. Wang G, Chen M, Wang J, Peng Y, Li L, Xie Z, et al. Synthesis, biological evaluation and molecular docking studies of chromone hydrazone derivatives as α-glucosidase inhibitors. Bioorg Med Chem Lett. 2017;27:2957-2961 pubmed publisher
    ..Docking studies showed 4d are interacting with the residues Glu-276, Asp-214, Asp-349 and Arg-439 through hydrogen bonds, arene-anion and arene-cation interactions...
  49. Guo J, Li J, Chen H, Bond P, Yuan Z. Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements. Water Res. 2017;123:468-478 pubmed publisher
    ..antibiotic resistance determinants was developed that consisted of four categories: gene transfer potential, ARG potential, ARGs pathway and ARGs phylogenetic origin...
  50. Niss Arfelt K, Fares S, Sparre Ulrich A, Hjortø G, Gasbjerg L, Mølleskov Jensen A, et al. Signaling via G proteins mediates tumorigenic effects of GPR87. Cell Signal. 2017;30:9-18 pubmed publisher
    ..transforming potential of GPR87 was correlated to the receptor signaling, as the signaling-impaired mutant R139A (Arg in the conserved "DRY"-motif at the bottom of transmembrane helix 3 of GPR87 substituted to Ala) showed a lower in ..
  51. Batuello C, Hauck P, Gendron J, Lehman J, Mayo L. Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase. Proc Natl Acad Sci U S A. 2015;112:1749-54 pubmed publisher
    ..Thus, our studies reveal how Mdm2 may neutralize and elevate p53 in actively proliferating cells and also provides a rationale for using therapies that target the Nedd8 pathway in wild-type p53 tumors. ..
  52. Ramasamy A, Curjuric I, Coin L, Kumar A, McArdle W, Imboden M, et al. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol. 2011;128:996-1005 pubmed publisher
    ..This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses. ..
  53. Gao T, Zhao M, Zhang L, Li J, Yu L, Lv P, et al. Effect of in ovo feeding of l-arginine on the hatchability, growth performance, gastrointestinal hormones, and jejunal digestive and absorptive capacity of posthatch broilers. J Anim Sci. 2017;95:3079-3092 pubmed publisher
    This study was conducted to investigate the effects of in ovo feeding (IOF) of Arg solution on the hatchability, growth performance, gastrointestinal hormones, serum AA, activities of digestive enzymes, and mRNA expressions of sensing ..
  54. Mehlitz A, Banhart S, Mäurer A, Kaushansky A, Gordus A, Zielecki J, et al. Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J Cell Biol. 2010;190:143-57 pubmed publisher
    ..trachomatis-induced cell survival and suggest that Tarp functions as a multivalent phosphorylation-dependent signaling hub that is important during the early phase of chlamydial infection. ..
  55. Zhang Y, Hu H, Gou M, Wang J, Chen D, He J. Temporal succession of soil antibiotic resistance genes following application of swine, cattle and poultry manures spiked with or without antibiotics. Environ Pollut. 2017;231:1621-1632 pubmed publisher
    ..total of 185 unique ARGs, with Macrolide-Lincosamide-Streptogramin B resistance as the most frequently encountered ARG type...
  56. Krzyaniak M, Cruce A, Vennam P, Lockart M, Berka V, Tsai A, et al. The tetrahydrobiopterin radical interacting with high- and low-spin heme in neuronal nitric oxide synthase - A new indicator of the extent of NOS coupling. Free Radic Biol Med. 2016;101:367-377 pubmed publisher
    ..With excess thiol, nNOSox lacking BH4 and l-arg is known to produce superoxide...
  57. Ooishi T, Nadano D, Matsuda T, Oshima K. Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells. Genes Cells. 2017;22:885-899 pubmed publisher
    Milk fat globule-EGF factor 8 (MFG-E8) is a divalent-binding secretory protein possessing an Arg-Gly-Asp (RGD) motif and a phosphatidylserine (PS)-binding motif...
  58. Garcia Pardo J, Tanco S, Diaz L, Dasgupta S, Fernandez Recio J, Lorenzo J, et al. Substrate specificity of human metallocarboxypeptidase D: Comparison of the two active carboxypeptidase domains. PLoS ONE. 2017;12:e0187778 pubmed publisher
    ..CPD cleaved C-terminal Lys or Arg from a subset of the peptides...
  59. Wada S, Iwata M, Ozaki Y, Ozaki T, Hayashi J, Urata H. Design of cyclic RGD-conjugated Aib-containing amphipathic helical peptides for targeted delivery of small interfering RNA. Bioorg Med Chem. 2016;24:4478-4485 pubmed publisher
    ..siRNA, five conjugates of Aib-containing amphipathic helical peptides with mono-, di-, and trivalent cRGDfC [cyclo(-Arg-Gly-Asp-d-Phe-Cys-)], which is known to bind to αVβ3 integrin, at several positions of the amphipathic helical ..
  60. Kato F, Tajima S, Nakayama E, Kawai Y, Taniguchi S, Shibasaki K, et al. Characterization of large and small-plaque variants in the Zika virus clinical isolate ZIKV/Hu/S36/Chiba/2016. Sci Rep. 2017;7:16160 pubmed publisher
    ..in the amino acid sequence), while clones forming large plaques had a guanine nucleotide (230Arg) at the same position, suggesting that this position was associated with the difference in plaque size...
  61. Rogozinskaya E, Lyapina M. Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography. Bull Exp Biol Med. 2017;: pubmed publisher
    ..Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro...
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    ..2 but differs considerably from mammalian Kir6.1 and Kir6.2 in the COOH terminus, which contain an Arg-Lys-Arg (RKR) motif, an endoplasmic reticulum (ER) retention signal...