ACACA

Summary

Gene Symbol: ACACA
Description: acetyl-CoA carboxylase alpha
Alias: ACAC, ACACAD, ACC, ACC1, ACCA, acetyl-CoA carboxylase 1, ACC-alpha, acetyl-Coenzyme A carboxylase alpha
Species: human
Products:     ACACA

Top Publications

  1. Ha J, Daniel S, Broyles S, Kim K. Critical phosphorylation sites for acetyl-CoA carboxylase activity. J Biol Chem. 1994;269:22162-8 pubmed
    Acetyl-CoA carboxylase (ACC) is rapidly regulated by reversible phosphorylation; phosphorylation inactivates ACC, whereas dephosphorylation activates the enzyme...
  2. Conde E, Suarez Gauthier A, Garcia Garcia E, Lopez Rios F, Lopez Encuentra A, Garcia Lujan R, et al. Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol. 2007;38:1351-60 pubmed
    ..used immunohistochemistry to evaluate the levels of LKB1 and the phosphorylated form of the acetyl-CoA carboxylase (ACC) protein in a variety of human adult normal tissues and in 159 lung carcinomas...
  3. Munday M, Campbell D, Carling D, Hardie D. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur J Biochem. 1988;175:331-8 pubmed
    ..They also open the way to experiments which could establish the physiological roles of these protein kinases in the control of fatty acid synthesis. ..
  4. Pezzani R, Rubin B, Bertazza L, Redaelli M, Barollo S, Monticelli H, et al. The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line. Invest New Drugs. 2016;34:531-40 pubmed publisher
    ..AKI Vx-680 are useless in the H295R cell model, and therefore should not be considered as potential treatments for ACC. Serine/threonine AK inhibition, essentially with VX-680, could be a promising, specific therapeutic tool for ..
  5. Lin D, Kao S, Ho C, Wei Y, Hung P, Hsu M, et al. Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease. Oncotarget. 2017;8:73627-73639 pubmed publisher
    ..The aberrant secondary cellular responses to disrupted metabolic homeostasis mediated by AMPK signaling pathway may contribute to the development of the clinical phenotype...
  6. Galdieri L, Gatla H, Vancurova I, Vancura A. Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells. J Biol Chem. 2016;291:25154-25166 pubmed
    ..AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC), which catalyzes carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting reaction in de novo ..
  7. Kalra A, Glusenkamp N, Anderson K, Kalra R, Kerkar P, Kumar G, et al. American College of Cardiology (ACC)'s PINNACLE India Quality Improvement Program (PIQIP)-Inception, progress and future direction: A report from the PIQIP Investigators. Indian Heart J. 2016;68 Suppl 3:S1-S4 pubmed publisher
    ..sup>5 This manuscript discusses the inception of the PIQIP registry, the progress it has made and challenges thus far, and its future direction and the promise it holds for cardiovascular care quality improvement in India. ..
  8. Zundler S, Strobel D, Manger B, Neurath M, Wildner D. Pancreatic Panniculitis and Polyarthritis. Curr Rheumatol Rep. 2017;19:62 pubmed publisher
    ..g., acute or chronic pancreatitis) or malign (e.g., acinar cell carcinoma (ACC) or adenocarcinoma) pancreatic disease...
  9. Jiang M, Ding H, Li C, Xiang K, Tang J, Guo Y, et al. Surgical resection of adrenocortical carcinoma with invasion into the inferior vena cava: a case report and literature review. Clin Case Rep. 2017;5:1934-1937 pubmed publisher
    Adrenocortical carcinoma (ACC) is a malignant endocrine tumor. Moreover, ACC with invasion into the inferior vena cava is rare. Early diagnosis and treatment are crucial for such cases...
  10. Mass T, Giuffre A, Sun C, Stifler C, Frazier M, Neder M, et al. Amorphous calcium carbonate particles form coral skeletons. Proc Natl Acad Sci U S A. 2017;114:E7670-E7678 pubmed publisher
    ..corals that two amorphous precursors exist, one hydrated and one anhydrous amorphous calcium carbonate (ACC); that these are formed in the tissue as 400-nm particles; and that they attach to the surface of coral skeletons, ..

Detail Information

Publications62

  1. Ha J, Daniel S, Broyles S, Kim K. Critical phosphorylation sites for acetyl-CoA carboxylase activity. J Biol Chem. 1994;269:22162-8 pubmed
    Acetyl-CoA carboxylase (ACC) is rapidly regulated by reversible phosphorylation; phosphorylation inactivates ACC, whereas dephosphorylation activates the enzyme...
  2. Conde E, Suarez Gauthier A, Garcia Garcia E, Lopez Rios F, Lopez Encuentra A, Garcia Lujan R, et al. Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol. 2007;38:1351-60 pubmed
    ..used immunohistochemistry to evaluate the levels of LKB1 and the phosphorylated form of the acetyl-CoA carboxylase (ACC) protein in a variety of human adult normal tissues and in 159 lung carcinomas...
  3. Munday M, Campbell D, Carling D, Hardie D. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur J Biochem. 1988;175:331-8 pubmed
    ..They also open the way to experiments which could establish the physiological roles of these protein kinases in the control of fatty acid synthesis. ..
  4. Pezzani R, Rubin B, Bertazza L, Redaelli M, Barollo S, Monticelli H, et al. The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line. Invest New Drugs. 2016;34:531-40 pubmed publisher
    ..AKI Vx-680 are useless in the H295R cell model, and therefore should not be considered as potential treatments for ACC. Serine/threonine AK inhibition, essentially with VX-680, could be a promising, specific therapeutic tool for ..
  5. Lin D, Kao S, Ho C, Wei Y, Hung P, Hsu M, et al. Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease. Oncotarget. 2017;8:73627-73639 pubmed publisher
    ..The aberrant secondary cellular responses to disrupted metabolic homeostasis mediated by AMPK signaling pathway may contribute to the development of the clinical phenotype...
  6. Galdieri L, Gatla H, Vancurova I, Vancura A. Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells. J Biol Chem. 2016;291:25154-25166 pubmed
    ..AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC), which catalyzes carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting reaction in de novo ..
  7. Kalra A, Glusenkamp N, Anderson K, Kalra R, Kerkar P, Kumar G, et al. American College of Cardiology (ACC)'s PINNACLE India Quality Improvement Program (PIQIP)-Inception, progress and future direction: A report from the PIQIP Investigators. Indian Heart J. 2016;68 Suppl 3:S1-S4 pubmed publisher
    ..sup>5 This manuscript discusses the inception of the PIQIP registry, the progress it has made and challenges thus far, and its future direction and the promise it holds for cardiovascular care quality improvement in India. ..
  8. Zundler S, Strobel D, Manger B, Neurath M, Wildner D. Pancreatic Panniculitis and Polyarthritis. Curr Rheumatol Rep. 2017;19:62 pubmed publisher
    ..g., acute or chronic pancreatitis) or malign (e.g., acinar cell carcinoma (ACC) or adenocarcinoma) pancreatic disease...
  9. Jiang M, Ding H, Li C, Xiang K, Tang J, Guo Y, et al. Surgical resection of adrenocortical carcinoma with invasion into the inferior vena cava: a case report and literature review. Clin Case Rep. 2017;5:1934-1937 pubmed publisher
    Adrenocortical carcinoma (ACC) is a malignant endocrine tumor. Moreover, ACC with invasion into the inferior vena cava is rare. Early diagnosis and treatment are crucial for such cases...
  10. Mass T, Giuffre A, Sun C, Stifler C, Frazier M, Neder M, et al. Amorphous calcium carbonate particles form coral skeletons. Proc Natl Acad Sci U S A. 2017;114:E7670-E7678 pubmed publisher
    ..corals that two amorphous precursors exist, one hydrated and one anhydrous amorphous calcium carbonate (ACC); that these are formed in the tissue as 400-nm particles; and that they attach to the surface of coral skeletons, ..
  11. Peng Y, Lei T, Yuan J, Chen X, Long Q, Zhang J, et al. Arachidonic acid induces acetyl-CoA carboxylase 1 expression via activation of CREB1. Endocrine. 2009;36:491-7 pubmed publisher
    ..In animals, there are two major isoforms of ACCs, ACC1 and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution...
  12. Johansen L, Naumanen T, Knudsen A, Westerlund N, Gromova I, Junttila M, et al. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci. 2008;121:854-64 pubmed publisher
    ..These results provide evidence for the role of the cytosolic interactions of IKAP in cell adhesion and migration, and support the notion that cell-motility deficiencies could contribute to FD. ..
  13. Tamang S, Findlater M. Iron Catalyzed Hydroboration of Aldehydes and Ketones. J Org Chem. 2017;: pubmed publisher
    We report an operationally convenient room temperature hydroboration of aldehydes and ketones employing Fe(acac)3 as precatalyst...
  14. Wang N, Liu Y, Ma Y, Wen D. High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice. Life Sci. 2017;191:122-131 pubmed publisher
    ..in preventing liver lipid accumulation by restoring mRNA levels of genes involved in hepatic lipogenesis (SREBP1, ACC1, FAS) and β-oxidation (PPARα, CPT1a, HAD)...
  15. Qin S, Han H, Zhang K, Ding X, Bai S, Wang J, et al. Dietary fibre alleviates hepatic fat deposition via inhibiting lipogenic gene expression in meat ducks. J Anim Physiol Anim Nutr (Berl). 2017;: pubmed publisher
    ..The transcription of fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) and sterol-regulatory element-binding protein-1 (SREBP-1) in liver was significantly reduced by DF, while no any ..
  16. Liu B, Mitani Y, Rao X, Zafereo M, Zhang J, Zhang J, et al. Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma. J Natl Cancer Inst. 2017;109: pubmed publisher
    Adenoid cystic carcinoma (ACC), an uncommon and indolent salivary gland malignancy, is characterized by varied morphologic and clinical manifestations...
  17. Milton Laskibar I, Aguirre L, Fernández Quintela A, Rolo A, Soeiro Teodoro J, Palmeira C, et al. Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats. Nutrients. 2017;9: pubmed publisher
    ..MTP, CPT1a, CS, COX, SDH and ATP synthase activities, FATP2/FATP5, DGAT2, PPARα, SIRT1, UCP2 protein expressions, ACC and AMPK phosphorylation and PGC1α deacetylation...
  18. Lipka A, Majewska M, Panasiewicz G, Bieniek Kobuszewska M, Szafranska B. Gene structure of the pregnancy-associated glycoprotein-like (PAG-L) in the Eurasian beaver (Castor fiber L.). Funct Integr Genomics. 2017;: pubmed publisher
    ..named CfPAG-L. We identified 7657 bp of the CfPAG-L gDNA sequence (Acc. No. KX377932), encompassing nine exons (1-9) and eight introns (A-H)...
  19. Braem S, King J, Korb F, Krebs R, Notebaert W, Egner T. The Role of Anterior Cingulate Cortex in the Affective Evaluation of Conflict. J Cogn Neurosci. 2017;29:137-149 pubmed
    An influential theory of ACC function argues that this brain region plays a crucial role in the affective evaluation of performance monitoring and control demands...
  20. Comte M, Zendjidjian X, Coull J, Cancel A, Boutet C, Schneider F, et al. Impaired cortico-limbic functional connectivity in schizophrenia patients during emotion processing. Soc Cogn Affect Neurosci. 2017;: pubmed publisher
    ..processes were associated with reduced interaction between the amygdala and both the anterior cingulate cortex (ACC) and the dorsolateral prefrontal cortex (DLPFC)...
  21. Paci P, Mayo N, Kaneva P, Fiore J, Fried G, Feldman L. Determinants of variability in management of acute calculous cholecystitis. Surg Endosc. 2017;: pubmed publisher
    ..evidence supports early compared to delayed cholecystectomy as optimal management of acute calculous cholecystitis (ACC), significant variability in practice remains...
  22. Moon H, Heo W, Kim Y, Lee D, Won S, Kim H, et al. Optical inactivation of the anterior cingulate cortex modulate descending pain pathway in a rat model of trigeminal neuropathic pain created via chronic constriction injury of the infraorbital nerve. J Pain Res. 2017;10:2355-2364 pubmed publisher
    The anterior cingulate cortex (ACC) plays a critical role in the initiation, development, and maintenance of neuropathic pain...
  23. Lewis L, Hernon J, Clark A, Saxton J. Validation of the IPAQ Against Different Accelerometer Cut-Points in Older Cancer Survivors and Adults at Risk of Cancer. J Aging Phys Act. 2017;:1-7 pubmed publisher
    ..Data from 52 participants (mean age 67.9 years, 62% male) were included in the analysis. Treadmill derived (TM-ACC: 1,952-5,724 cpm) and free-living physical activity (PA) derived (FL-ACC: 760-5,724 cpm) accelerometer cut-points ..
  24. Pascual J, García López M, Gonzalez I, Genilloud O. Luteolibacter gellanilyticus sp. nov., a gellan-gum-degrading bacterium of the phylum Verrucomicrobia isolated from miniaturized diffusion chambers. Int J Syst Evol Microbiol. 2017;67:3951-3959 pubmed publisher
    ..as a member of the genus Luteolibacter where the type strains Luteolibacterpohnpeiensis A4T-83T (GenBank acc. no...
  25. Zhu X, Zhu C, Wang C, Dong X, Shen R. Nitric oxide acts upstream of ethylene in cell wall phosphorus reutilization in phosphorus-deficient rice. J Exp Bot. 2017;68:753-760 pubmed publisher
    ..decreased the production of ethylene, while neither the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) nor the ethylene inhibitor aminoethoxyvinylglycine (AVG) had any influence on NO accumulation, suggesting NO acted ..
  26. Arguin G, Bourzac J, Placet M, Molle C, Paquette M, Beaudoin J, et al. The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Sci Rep. 2017;7:12917 pubmed publisher
    ..Finally, P2rx7 -/- mice developed a hepatic steatosis characterized by a reduction of Acaca, Acacb, Fasn and Acox1 mRNA expression, as well as for ACC and FAS protein expression...
  27. Fang W, Cui H, Yu D, Chen Y, Wang J, Yu G. Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis. Med Oncol. 2014;31:15 pubmed publisher
    Upregulation of acetyl-CoA carboxylase (ACC), as a rate-limiting enzyme of fatty acid synthesis,has been recognized in multiple human cancers, implicating a critical role in cancer development and progression; yet, its role in gastric ..
  28. KEENAN M, Liu B, Tang X, Wu J, Cyr D, Stevens R, et al. ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. PLoS Genet. 2015;11:e1005599 pubmed publisher
    ..We discovered that genetic depletion of acetyl-CoA carboxylase (ACACA or ACC1) or ATP citrate lyase (ACLY) protected cancer cells from hypoxia-induced apoptosis...
  29. Cocker P, Hosking J, Murch W, Clark L, Winstanley C. Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task. Neuropharmacology. 2016;105:186-195 pubmed publisher
    ..enriched within frontal and limbic areas activated during slot machine play, such as the anterior cingulate cortex (ACC)...
  30. Phattarataratip E, Dhanuthai K. Expression of C-X-C motif chemokine receptors 4 and 7 in salivary gland neoplasms. Arch Oral Biol. 2017;83:136-144 pubmed publisher
    ..cases of salivary gland neoplasms, including 25 mucoepidermoid carcinomas (MEC), 18 adenoid cystic carcinomas (ACC), 14 pleomorphic adenomas (PA) and 5 polymorphous low-grade adenocarcinoma (PLGA) were investigated for CXCR4 and ..
  31. Lavandera J, Gerstner C, Saín J, Fariña A, Gonzalez M, Bernal C. Maternal conjugated linoleic acid modulates TAG metabolism in adult rat offspring. Br J Nutr. 2017;118:906-913 pubmed publisher
    ..in the CLA/CLA group, related to a significant reduction of fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) and glucose-6-phosphate dehydrogenase enzyme activities, as well as to the mRNA levels of FAS, ACC, stearoyl-CoA ..
  32. Haham H, Grinblat J, Sougrati M, Stievano L, Margel S. Engineering of Iron-Based Magnetic Activated Carbon Fabrics for Environmental Remediation. Materials (Basel). 2015;8:4593-4607 pubmed publisher
    ..the pores of activated carbon fabrics (ACF) were prepared by impregnation of the ACF in iron acetylacetanoate (Fe(acac)₃) ethanol solution, followed by thermal decomposition of the embedded iron precursor at 200, 400 and 600 °C in ..
  33. Ball M, Gorin M, Drake C, Hammers H, Allaf M. The Landscape of Whole-genome Alterations and Pathologic Features in Genitourinary Malignancies: An Analysis of the Cancer Genome Atlas. Eur Urol Focus. 2017;: pubmed publisher
    ..TCGA data sets for adrenocortical carcinoma (ACC), bladder urothelial carcinoma (BLCA), chromophobe renal cell carcinoma (RCC; KICH), clear cell RCC (KIRC), ..
  34. Han J, Won J, Hong S, Kim J, Kim E, Kim H, et al. Objective measurement of subjective tinnitus using the acoustic change complex. PLoS ONE. 2017;12:e0188268 pubmed publisher
    ..Recently, the acoustic change complex (ACC) has been used to evaluate neural detection of sounds...
  35. Kim E, Kyeong S, Cheon K, Park B, Oh M, Chun J, et al. Neural responses to affective and cognitive theory of mind in children and adolescents with autism spectrum disorder. Neurosci Lett. 2016;621:117-125 pubmed publisher
    ..In cognitive ToM tasks, ASD participants recruited the medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), and superior temporal gyrus (STG) to a greater extent than did TDCs...
  36. Bouchard Mercier A, Rudkowska I, Lemieux S, Couture P, Vohl M. Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation. J Lipid Res. 2013;54:2866-73 pubmed publisher
    ..9-2.2 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid. SNPs within SREBF1, ACLY, and ACACA genes were genotyped using TAQMAN methodology...
  37. Bozkaya Y, Çetinkaya E, Erdem G, Çiftçi A, Karahaliloğlu E, Ozdemir N. Small bowel and cecal Involvement: Unusual metastasis sites from adenoid cystic carcinoma of the minor salivary gland. J Cancer Res Ther. 2017;13:1070-1072 pubmed publisher
    Adenoid cystic carcinoma (ACC) is a rare neoplasm and the most frequent pathology occurring in the minor salivary glands. Lung, bone, liver, and brain are the most frequent metastasis sites in ACC cases...
  38. Hough C, Luks T, Lai K, Vigil O, Guillory S, Nongpiur A, et al. Comparison of brain activation patterns during executive function tasks in hoarding disorder and non-hoarding OCD. Psychiatry Res. 2016;255:50-9 pubmed publisher
    ..task, individuals with HD had significantly greater activity than controls in the anterior cingulate cortex (ACC) and right dorsolateral prefrontal cortex (DLPFC)...
  39. Macías Sánchez E, Willinger M, Pina C, Checa A. Transformation of ACC into aragonite and the origin of the nanogranular structure of nacre. Sci Rep. 2017;7:12728 pubmed publisher
    ..We propose that the final nanogranular structure observed is produced during the transformation of ACC into aragonite.
  40. Yang C, Liu J, Wu X, Bao P, Long R, Guo X, et al. The response of gene expression associated with lipid metabolism, fat deposition and fatty acid profile in the longissimus dorsi muscle of Gannan yaks to different energy levels of diets. PLoS ONE. 2017;12:e0187604 pubmed publisher
    ..Relative expression of acetyl-CoA carboxylase (ACACA), fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), sterol regulatory element-binding protein-1c (SREBP-..
  41. Tang Y, Zhang Y. [Molecular mechanisms of NMDA receptor-MAPK-CREB pathway underlying the involvement of the anterior cingulate cortex in pain-related aversion]. Sheng Li Xue Bao. 2017;69:637-646 pubmed
    ..of pain, elaborates the neuronal mechanisms of pain-related aversive emotion in the anterior cingulate cortex (ACC), especially the critical role of NMDA receptors and ERK-CREB pathway...
  42. Kramer P, Strand J, Stinson C, Bellinger L, Kinchington P, Yee M, et al. Role for the Ventral Posterior Medial/Posterior Lateral Thalamus and Anterior Cingulate Cortex in Affective/Motivation Pain Induced by Varicella Zoster Virus. Front Integr Neurosci. 2017;11:27 pubmed publisher
    ..In addition, the anterior cingulate cortex (ACC) has been shown to be vital in the affective experience of pain, so investigating both of these areas in freely ..
  43. Han H, Qiu F, Zhao H, Tang H, Li X, Shi D. Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice. Oxid Med Cell Longev. 2017;2017:3256241 pubmed publisher
    ..associated with the modification effects on expression levels of genes involved in de novo fat synthesis (SREBP-1c, ACC), triacylglycerol catabolism (PPARα, CPT1A, and ACOX1), inflammation (NF-κB, IL-6, TNF-α, ..
  44. Shimada M, Hibino M, Takeshita A. Dietary supplementation with myo-inositol reduces hepatic triglyceride accumulation and expression of both fructolytic and lipogenic genes in rats fed a high-fructose diet. Nutr Res. 2017;47:21-27 pubmed publisher
    ..Taken together, this study showed that MI supplementation decreases the expression of fructolytic/lipogenic genes and lipogenic proteins as well as TG accumulation in high fructose-induced fatty liver in rats...
  45. Panda S, Kar A, Biswas S. Preventive effect of Agnucastoside C against Isoproterenol-induced myocardial injury. Sci Rep. 2017;7:16146 pubmed publisher
    An iridoid glycoside, agnucastoside C (ACC) was isolated from the leaves of Moringa oliefera and its cardio protective potential was investigated in adult rats by examining the effects of this test compound, ACC at 30 mg/kg for 14 days ..
  46. Xu X, Wang Y, Wei Z, Wei W, Zhao P, Tong B, et al. Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway. Cell Death Dis. 2017;8:e2723 pubmed publisher
    ..Under Th17-polarizing conditions, madecassic acid downregulated ACC1 expression and enhanced the shift of Th17 cells toward Treg cells, but it did not affect the differentiation of ..
  47. Yatscoff M, Jaswal J, Grant M, Greenwood R, Lukat T, Beker D, et al. Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart. Pediatr Res. 2008;64:643-7 pubmed publisher
    ..is due to increased activity of malonyl CoA decarboxylase (MCD), and decreased activity of acetyl CoA carboxylase (ACC), enzymes which degrade and synthesize malonyl CoA, respectively...
  48. Zhang H, Ruan Z, Sang W. HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation. J Cell Physiol. 2011;226:3385-91 pubmed publisher
    ..Curcumin reversed Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase (ACC) activation...
  49. Garner C, Ahn R, Ding Y, Steele L, Stoven S, Green P, et al. Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. PLoS ONE. 2014;9:e101428 pubmed publisher
    ..Preliminary, suggestive statistical evidence for association with the two traits was found at chromosomes 3p21.31, 6q15, 6q25, 1q24.3 and 10p11.23, with future studies being required to validate the reported associations. ..
  50. Marsh A, Edwards T, Galea C, Cooper H, Engle E, Jamuar S, et al. DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome. Hum Mutat. 2017;: pubmed publisher
    ..loss-of-function DCC mutations cause congenital mirror movements, isolated agenesis of the corpus callosum (ACC), or both. Biallelic, predicted loss-of-function DCC mutations cause developmental split brain syndrome (DSBS)...
  51. Lee D, Youn H, Jung H, Chang K, Choi Y, Jung J. Coronary artery calcium score plays an important role for cardiovascular risk stratification in the statin benefit groups of asymptomatic individuals. Lipids Health Dis. 2017;16:172 pubmed publisher
    ..9%) and low-intensity (n = 931, 23.8%) statin therapy groups) according to the American College of Cardiology (ACC)/American heart Association (AHA) 2013 guideline and the relationship between CACS and statin benefit group was ..
  52. Cheng Lai A, Snead J, Ng C, Verges C, Chung P. Comparison of Adherence to the 2013 ACC/AHA Cholesterol Guideline in a Teaching Versus Nonteaching Outpatient Clinic. Ann Pharmacother. 2017;:1060028017739325 pubmed publisher
    Little information is available regarding prescribers' adherence rate to the 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guideline, especially that from a teaching versus a nonteaching setting.
  53. Gunasekaran P, Jeevanantham V, Sharma S, Thapa R, Gupta K. Implications of the 2013 ACC/AHA cholesterol guidelines on contemporary clinical practice for patients with atherosclerotic coronary and peripheral arterial disease. Indian Heart J. 2017;69:464-468 pubmed publisher
    Cholesterol management guidelines from the American College of Cardiology/American Heart Association (ACC/AHA-2013) recommend fixed statin dosing (dose depends on age ≤ or >75years) compared to the earlier adult treatment panel III (..
  54. Johnson J, Barrett C, Franklin W, Graham E, Halnon N, Hattendorf B, et al. Development of quality metrics for ambulatory pediatric cardiology: Infection prevention. Congenit Heart Dis. 2017;12:756-761 pubmed publisher
    In 2012, the American College of Cardiology's (ACC) Adult Congenital and Pediatric Cardiology Council established a program to develop quality metrics to guide ambulatory practices for pediatric cardiology...
  55. Mathew R, Undurraga J, Li G, Meerton L, Boyle P, Shaida A, et al. Objective assessment of electrode discrimination with the auditory change complex in adult cochlear implant users. Hear Res. 2017;354:86-101 pubmed publisher
    The spatial auditory change complex (ACC) is a cortical response elicited by a change in place of stimulation...
  56. Qi N, Liu C, Yang H, Shi W, Wang S, Zhou Y, et al. Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism and oxidative stress. Oncotarget. 2017;8:88079-88093 pubmed publisher
    ..The gene expressions and/or activities related to liver injury, lipid metabolism and oxidation, such as ACC, PPAR-γ, CHOP and Caspase-3, were assessed by real time PCR and western blot...
  57. Bebb O, Hall M, Fox K, Dondo T, Timmis A, Bueno H, et al. Performance of hospitals according to the ESC ACCA quality indicators and 30-day mortality for acute myocardial infarction: national cohort study using the United Kingdom Myocardial Ischaemia National Audit Project (MINAP) register. Eur Heart J. 2017;38:974-982 pubmed publisher
    ..To investigate the application of the European Society of Cardiology Acute Cardiovascular Care Association quality indicators (QI) for acute myocardial infarction for the study of hospital performance and 30-day mortality...
  58. Proverbio A, Cozzi M, Orlandi A, Carminati M. Error-related negativity in the skilled brain of pianists reveals motor simulation. Neuroscience. 2017;346:309-319 pubmed publisher
    ..ERN was mostly explained by an anterior cingulate cortex (ACC) source...
  59. Lu Z, He X, Ma B, Zhang L, Li J, Jiang Y, et al. Chronic Heat Stress Impairs Meat Quality of Breast Muscle in Broilers through Affecting Redox Status and Energy Substances Metabolism. J Agric Food Chem. 2017;: pubmed publisher
    ..Meanwhile, heat exposure increased the mRNA expression of FAS, ACC and PDK4, content of lipid and activities of lactic dehydrogenase and pyruvate kinase, and decreased the mRNA ..
  60. Rinne Albers M, Pannekoek J, van Hoof M, van Lang N, Lamers Winkelman F, Rombouts S, et al. Anterior cingulate cortex grey matter volume abnormalities in adolescents with PTSD after childhood sexual abuse. Eur Neuropsychopharmacol. 2017;27:1163-1171 pubmed publisher
    ..Hippocampus, amygdala, anterior cingulate cortex (ACC), medial PFC (mPFC) and superior temporal gyrus (STG) were chosen as regions of interest (ROIs)...
  61. Berger R, Girichev G, Giricheva N, Petrova A, Tverdova N. The Structure of Mn(acac)3 -Experimental Evidence of a Static Jahn-Teller Effect in the Gas Phase. Angew Chem Int Ed Engl. 2017;: pubmed publisher
    The structure of free manganese(III) tris(acetylacetonate) [Mn(acac)3 ] was determined by mass-spectrometrically controlled gas-phase electron diffraction...
  62. El Sahili A, Li S, Lang J, Virus C, Planamente S, Ahmar M, et al. A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens. PLoS Pathog. 2015;11:e1005071 pubmed publisher
    ..This organism contains a PBP called AccA that mediates the import of the antibiotic agrocin 84, as well as the opine agrocinopine A that acts as both a ..