ACADS

Summary

Gene Symbol: ACADS
Description: acyl-CoA dehydrogenase short chain
Alias: ACAD3, SCAD, short-chain specific acyl-CoA dehydrogenase, mitochondrial, acyl-CoA dehydrogenase, C-2 to C-3 short chain, acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain, butyryl-CoA dehydrogenase, mitochondrial short-chain specific acyl-CoA dehydrogenase, unsaturated acyl-CoA reductase
Species: human
Products:     ACADS

Top Publications

  1. van Maldegem B, Waterham H, Duran M, van der Vlies M, van Woerden C, Bobu L, et al. The 625G>A SCAD gene variant is common but not associated with increased C4-carnitine in newborn blood spots. J Inherit Metab Dis. 2005;28:557-62 pubmed
    The 625G>A variant of the short-chain acyl-CoA dehydrogenase (SCAD) gene is considered to confer susceptibility for developing 'clinical SCAD deficiency' and appears to be common in the general population...
  2. Illig T, Gieger C, Zhai G, Römisch Margl W, Wang Sattler R, Prehn C, et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010;42:137-41 pubmed publisher
    ..For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes or ..
  3. Jethva R, Bennett M, Vockley J. Short-chain acyl-coenzyme A dehydrogenase deficiency. Mol Genet Metab. 2008;95:195-200 pubmed publisher
    ..The long-term consequences and the need for chronic therapy remain current topics of contention and investigation. ..
  4. Li D, Yan J, Yuan Y, Wang C, Wu J, Chen Q, et al. Genome-wide DNA methylome alterations in acute coronary syndrome. Int J Mol Med. 2018;41:220-232 pubmed publisher
    ..polymerase chain reaction (MSP) and Sequenom MassARRAY analyses in ACS, stable coronary artery disease (SCAD) and control samples...
  5. Koda S, Onda Y, Matsui H, Takahagi K, Yamaguchi Uehara Y, Shimizu M, et al. Diurnal Transcriptome and Gene Network Represented through Sparse Modeling in Brachypodium distachyon. Front Plant Sci. 2017;8:2055 pubmed publisher
    ..analysis and an Auto-Regressive eXogenous (ARX) model with a group smoothly clipped absolute deviation (SCAD) method using a time-series transcriptome dataset in a model grass, Brachypodium distachyon...
  6. Ryckman K, Smith C, Jelliffe Pawlowski L, Momany A, Berberich S, Murray J. Metabolic heritability at birth: implications for chronic disease research. Hum Genet. 2014;133:1049-57 pubmed publisher
    ..SNPs (rs2066938, rs3916, rs3794215, rs555404, rs558314, rs1799958) in the short-chain acyl-CoA dehydrogenase gene (ACADS) were associated with neonatal C4 levels...
  7. Kahles F, Schuh A, Lehrke M, Burgmaier M, Marx N, Reith S. [Non-ST-Segment Elevation Myocardial Infarction Caused by Spontaneous Coronary Thrombosis by Intimal Rupture]. Dtsch Med Wochenschr. 2017;142:1686-1689 pubmed publisher
    ..b>Conclusion Coronary thrombosis of our patient was caused by spontaneous coronary artery dissection (SCAD). SCAD is an important differential diagnosis in patients with ACS...
  8. Edhager A, Stenbroen V, Nielsen N, Bross P, Olsen R, Gregersen N, et al. Proteomic investigation of cultivated fibroblasts from patients with mitochondrial short-chain acyl-CoA dehydrogenase deficiency. Mol Genet Metab. 2014;111:360-368 pubmed publisher
    ..study, the mitochondrial proteome of five symptomatic patients homozygous for missense variations in the SCAD gene ACADS was investigated in an extensive large-scale proteomic study to map protein perturbations linked to the disease...
  9. Stodółkiewicz E, Rewerska B, Rzeszutko M, Tomala M, Chrustowicz A, Zmudka K, et al. Leukotrienes biosynthesis in coronary artery disease - results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) study. Pol Arch Intern Med. 2017;: pubmed publisher
    ..OBJECTIVES    1) to compare the baseline production of LTs in stable coronary artery disease (sCAD) and myocardial infarction (MI), and 2) assess whether increased production of LTs is associated with major adverse ..
  10. Zellweger M, Haaf P, Maraun M, Osterhues H, Keller U, Muller Brand J, et al. Predictors and prognostic impact of silent coronary artery disease in asymptomatic high-risk patients with diabetes mellitus. Int J Cardiol. 2017;244:37-42 pubmed publisher
    Evaluation of predictors of silent coronary artery disease (SCAD) in high-risk asymptomatic diabetic patients and to evaluate their two-year outcome...

Detail Information

Publications62

  1. van Maldegem B, Waterham H, Duran M, van der Vlies M, van Woerden C, Bobu L, et al. The 625G>A SCAD gene variant is common but not associated with increased C4-carnitine in newborn blood spots. J Inherit Metab Dis. 2005;28:557-62 pubmed
    The 625G>A variant of the short-chain acyl-CoA dehydrogenase (SCAD) gene is considered to confer susceptibility for developing 'clinical SCAD deficiency' and appears to be common in the general population...
  2. Illig T, Gieger C, Zhai G, Römisch Margl W, Wang Sattler R, Prehn C, et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010;42:137-41 pubmed publisher
    ..For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes or ..
  3. Jethva R, Bennett M, Vockley J. Short-chain acyl-coenzyme A dehydrogenase deficiency. Mol Genet Metab. 2008;95:195-200 pubmed publisher
    ..The long-term consequences and the need for chronic therapy remain current topics of contention and investigation. ..
  4. Li D, Yan J, Yuan Y, Wang C, Wu J, Chen Q, et al. Genome-wide DNA methylome alterations in acute coronary syndrome. Int J Mol Med. 2018;41:220-232 pubmed publisher
    ..polymerase chain reaction (MSP) and Sequenom MassARRAY analyses in ACS, stable coronary artery disease (SCAD) and control samples...
  5. Koda S, Onda Y, Matsui H, Takahagi K, Yamaguchi Uehara Y, Shimizu M, et al. Diurnal Transcriptome and Gene Network Represented through Sparse Modeling in Brachypodium distachyon. Front Plant Sci. 2017;8:2055 pubmed publisher
    ..analysis and an Auto-Regressive eXogenous (ARX) model with a group smoothly clipped absolute deviation (SCAD) method using a time-series transcriptome dataset in a model grass, Brachypodium distachyon...
  6. Ryckman K, Smith C, Jelliffe Pawlowski L, Momany A, Berberich S, Murray J. Metabolic heritability at birth: implications for chronic disease research. Hum Genet. 2014;133:1049-57 pubmed publisher
    ..SNPs (rs2066938, rs3916, rs3794215, rs555404, rs558314, rs1799958) in the short-chain acyl-CoA dehydrogenase gene (ACADS) were associated with neonatal C4 levels...
  7. Kahles F, Schuh A, Lehrke M, Burgmaier M, Marx N, Reith S. [Non-ST-Segment Elevation Myocardial Infarction Caused by Spontaneous Coronary Thrombosis by Intimal Rupture]. Dtsch Med Wochenschr. 2017;142:1686-1689 pubmed publisher
    ..b>Conclusion Coronary thrombosis of our patient was caused by spontaneous coronary artery dissection (SCAD). SCAD is an important differential diagnosis in patients with ACS...
  8. Edhager A, Stenbroen V, Nielsen N, Bross P, Olsen R, Gregersen N, et al. Proteomic investigation of cultivated fibroblasts from patients with mitochondrial short-chain acyl-CoA dehydrogenase deficiency. Mol Genet Metab. 2014;111:360-368 pubmed publisher
    ..study, the mitochondrial proteome of five symptomatic patients homozygous for missense variations in the SCAD gene ACADS was investigated in an extensive large-scale proteomic study to map protein perturbations linked to the disease...
  9. Stodółkiewicz E, Rewerska B, Rzeszutko M, Tomala M, Chrustowicz A, Zmudka K, et al. Leukotrienes biosynthesis in coronary artery disease - results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) study. Pol Arch Intern Med. 2017;: pubmed publisher
    ..OBJECTIVES    1) to compare the baseline production of LTs in stable coronary artery disease (sCAD) and myocardial infarction (MI), and 2) assess whether increased production of LTs is associated with major adverse ..
  10. Zellweger M, Haaf P, Maraun M, Osterhues H, Keller U, Muller Brand J, et al. Predictors and prognostic impact of silent coronary artery disease in asymptomatic high-risk patients with diabetes mellitus. Int J Cardiol. 2017;244:37-42 pubmed publisher
    Evaluation of predictors of silent coronary artery disease (SCAD) in high-risk asymptomatic diabetic patients and to evaluate their two-year outcome...
  11. Ahmed M, Hamra M, Ali M, Abdullah A, Arnous S, Kiernan T. Spontaneous coronary artery dissection, challenges of diagnosis and management. Future Cardiol. 2017;13:539-549 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndrome in young patients. No clear factors exist to predict the natural history of the disease and the prognosis of the condition...
  12. Du Y, Han K, Bai L, Liu P. [A rare case of spontaneous coronary artery dissection after emotional stress in a postmenopausal woman]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1010-1013 pubmed
    Spontaneous coronary artery dissection (SCAD) is a rare cause of acute myocardial infarction. While its etiology and pathogenesis remain not fully understood, SCAD occurs most frequently in patients at a young age and of a female gender...
  13. Giusti L, Mantua V, Da Valle Y, Ciregia F, Ventroni T, Orsolini G, et al. Search for peripheral biomarkers in patients affected by acutely psychotic bipolar disorder: a proteomic approach. Mol Biosyst. 2014;10:1246-54 pubmed publisher
    ....
  14. Zoladz J, Koziel A, Broniarek I, Woyda Ploszczyca A, Ogrodna K, Majerczak J, et al. Effect of temperature on fatty acid metabolism in skeletal muscle mitochondria of untrained and endurance-trained rats. PLoS ONE. 2017;12:e0189456 pubmed publisher
    ..such as fatty acid transporter CD36, carnitine palmitoyltransferase 1A (CPT1A), and acyl-CoA dehydrogenase (ACADS)...
  15. Nagelkerken I, Pitt K, Rutte M, Geertsma R. Ocean acidification alters fish-jellyfish symbiosis. Proc Biol Sci. 2016;283: pubmed publisher
    ..The total time that fish (yellowtail scad) spent close to their jellyfish host in a choice arena where they could see and smell their host was approximately ..
  16. Mahmoud A, Taduru S, Mentias A, Mahtta D, Barakat A, Saad M, et al. Trends of Incidence, Clinical Presentation, and In-Hospital Mortality Among Women With Acute Myocardial Infarction With or Without Spontaneous Coronary Artery Dissection: A Population-Based Analysis. JACC Cardiovasc Interv. 2018;11:80-90 pubmed publisher
    ..survival of women presenting with acute myocardial infarction (AMI) and spontaneous coronary artery dissection (SCAD). The clinical presentation and in-hospital survival of women with AMI and SCAD remains unclear...
  17. Meierhofer D, Halbach M, Şen N, Gispert S, Auburger G. Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations. Mol Cell Proteomics. 2016;15:1728-39 pubmed publisher
    ..In liver tissue, significant downregulations of the proteins ACADS, ALDH6A1, ALDH7A1, IVD, MCCC2, PCCA, OTC, together with bioinformatic enrichment of downregulated pathways for ..
  18. Vengalil S, Preethish Kumar V, Polavarapu K, Christopher R, Gayathri N, Natarajan A, et al. Fatty acid oxidation defects presenting as primary myopathy and prominent dropped head syndrome. Neuromuscul Disord. 2017;27:986-996 pubmed publisher
    ..deficiency (VLCAD) = 7; MADD = 6; carnitine uptake defect and short chain acyl CoA dehydrogenase (SCAD) deficiency = 1 each. The age at onset for MCAD, VLCAD and MADD ranged from 11...
  19. Al Fakih A, Algamal Z, Lee M, Aziz M. A sparse QSRR model for predicting retention indices of essential oils based on robust screening approach. SAR QSAR Environ Res. 2017;28:691-703 pubmed publisher
    ..Second, prediction of RIs was made using the proposed robust sparse QSRR with smoothly clipped absolute deviation (SCAD) penalty (RSQSRR)...
  20. Battisti C, Forte F, Molinelli M, Funghini S, Pasquini E, Tassini M, et al. A new case of short-chain acyl-CoA dehydrogenase deficiency: clinical, biochemical, genetic and (1)H-NMR spectroscopic studies. Neurol Sci. 2007;28:328-30 pubmed publisher
    Short-chain-acyl-CoA-dehydrogenase (SCAD) deficiency is an inborn error of mitochondrial fatty acid metabolism caused by rare mutations as well as common susceptibility variations in the SCAD gene...
  21. Demmer J, Pal Chowdhury N, Selmer T, Ermler U, Buckel W. The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile. Nat Commun. 2017;8:1577 pubmed publisher
    ..One electron goes to ferredoxin and one to α-FAD, which swings over to reduce δ-FAD to the semiquinone. Repetition affords a second reduced ferredoxin and δ-FADH-, which reduces crotonyl-CoA. ..
  22. Bulut F, Kor D, Seker Yilmaz B, Gul Mert G, Kılavuz S, Onenli Mungan N. Turkish case of ethylmalonic encephalopathy misdiagnosed as short chain acyl-CoA dehydrogenase deficiency. Metab Brain Dis. 2017;: pubmed publisher
    ..Here, we describe a case of ethylmalonic encephalopathy with late onset neurologic symptoms and a confusing family history of two deceased brothers with the wrong suspicion of short chain acyl-CoA dehydrogenase deficiency...
  23. Corydon M, Vockley J, Rinaldo P, Rhead W, Kjeldsen M, Winter V, et al. Role of common gene variations in the molecular pathogenesis of short-chain acyl-CoA dehydrogenase deficiency. Pediatr Res. 2001;49:18-23 pubmed
    ABSTRACT Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is considered a rare inherited mitochondrial fatty acid oxidation disorder...
  24. Osadnik T, Lekston A, Bujak K, Strzelczyk J, Polonski L, Gasior M. The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective Percutaneous Coronary Intervention. Dis Markers. 2017;2017:8165219 pubmed publisher
    ..A total of 676 patients (805 lesions) with stable coronary artery disease (SCAD) who received elective percutaneous coronary intervention (PCI) with at least one bare-metal stent implantation ..
  25. Hornbak M, Banasik K, Justesen J, Krarup N, Sandholt C, Andersson A, et al. The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. BMC Med Genet. 2011;12:4 pubmed publisher
    ..activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid β-..
  26. Munguti C, Ndunda P, Muutu T. Sudden Death from Spontaneous Coronary Artery Dissection due to Polyarteritis Nodosa. Cureus. 2017;9:e1737 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is an emerging and rare cause of acute coronary syndrome and sudden cardiac death...
  27. Mishra S, Ray S, Dalal J, Sawhney J, Ramakrishnan S, Nair T, et al. Management standards for stable coronary artery disease in India. Indian Heart J. 2016;68 Suppl 3:S31-S49 pubmed publisher
    ..Stable coronary artery disease (SCAD) is characterised by episodes of transient central chest pain (angina pectoris), often triggered by exercise, ..
  28. Gregersen N, Winter V, Corydon M, Corydon T, Rinaldo P, Ribes A, et al. Identification of four new mutations in the short-chain acyl-CoA dehydrogenase (SCAD) gene in two patients: one of the variant alleles, 511C-->T, is present at an unexpectedly high frequency in the general population, as was the case for 625G-->. Hum Mol Genet. 1998;7:619-27 pubmed
    We have shown previously that a variant allele of the short-chain acyl-CoA dehydrogenase ( SCAD ) gene, 625G-->A, is present in homozygous form in 7% of control individuals and in 60% of 135 patients with elevated urinary excretion of ..
  29. Zanchin T, Räber L, Koskinas K, Piccolo R, Juni P, Pilgrim T, et al. Preprocedural High-Sensitivity Cardiac Troponin T and Clinical Outcomes in Patients With Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention. Circ Cardiovasc Interv. 2016;9: pubmed publisher
    ..highly sensitive assays predicts clinical outcomes among patients with stable coronary artery disease (SCAD) treated medically...
  30. Naito E, Indo Y, Tanaka K. Identification of two variant short chain acyl-coenzyme A dehydrogenase alleles, each containing a different point mutation in a patient with short chain acyl-coenzyme A dehydrogenase deficiency. J Clin Invest. 1990;85:1575-82 pubmed
    Two distinct mutant alleles of the precursor (p) short chain acyl-CoA dehydrogenase (SCAD) gene were identified in a SCAD-deficient patient (YH2065) using the polymerase chain reaction to amplify cDNA synthesized from total RNA from her ..
  31. Roule V, Blanchart K, Lemaitre A, Bignon M, Sabatier R, Beygui F. Recurrent unexpected myocardial infarction in a young woman: Insights on spontaneous coronary artery dissection and multimodality imaging. Cardiovasc Revasc Med. 2017;: pubmed publisher
    ..An optical coherence tomography (OCT) revealed a spontaneous coronary artery dissection (SCAD) with an extensive compressive mural hematoma without any intimal tear. Conservative treatment was continued...
  32. Sun X, Duan X, Wang C, Liu Z, Sun P, Huo X, et al. Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice. Eur J Pharmacol. 2017;806:75-82 pubmed publisher
    ..SREBP-1c, FAS and SCD1 expression, increased fatty acids β-oxidation via an increase in PPARα, CPT1α and ACADS, and promoted triglyceride metabolism through inducing LPL activity...
  33. Kim Y, Cheon C, Park K, Park S, Kim G, Yoo H, et al. Novel and Recurrent ACADS Mutations and Clinical Manifestations Observed in Korean Patients with Short-chain Acyl-coenzyme a Dehydrogenase Deficiency. Ann Clin Lab Sci. 2016;46:360-6 pubmed
    ..the first step in mitochondrial short-chain β-oxidation, and its deficiency is caused by mutations in the ACADS We sought to investigate the spectrum ACADS mutations and associated clinical manifestations in Korean patients ..
  34. Nagan N, Kruckeberg K, Tauscher A, Bailey K, Rinaldo P, Matern D. The frequency of short-chain acyl-CoA dehydrogenase gene variants in the US population and correlation with the C(4)-acylcarnitine concentration in newborn blood spots. Mol Genet Metab. 2003;78:239-46 pubmed
    Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is a clinically heterogeneous disorder. The clinical phenotype varies from fatal metabolic decompensation in early life to subtle adult onset, some patients remain asymptomatic...
  35. Tein I, Elpeleg O, Ben Zeev B, Korman S, Lossos A, Lev D, et al. Short-chain acyl-CoA dehydrogenase gene mutation (c.319C>T) presents with clinical heterogeneity and is candidate founder mutation in individuals of Ashkenazi Jewish origin. Mol Genet Metab. 2008;93:179-89 pubmed
    ..625G>A variant on the other in the short-chain acyl-CoA dehydrogenase (SCAD) gene (ACADS). All were of Ashkenazi Jewish origin in which group we found a c...
  36. Sjöholm L, Kovanen L, Saarikoski S, Schalling M, Lavebratt C, Partonen T. CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. J Circadian Rhythms. 2010;8:1 pubmed publisher
    ..Together with previous reports it indicates that the CLOCK variations we found here may be a vulnerability factor to depression given the exposure to alcohol in individuals having AUD. ..
  37. Rueedi R, Ledda M, Nicholls A, Salek R, Marques Vidal P, Morya E, et al. Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links. PLoS Genet. 2014;10:e1004132 pubmed publisher
    ..The replication of previous associations and our new discoveries demonstrate the potential of untargeted metabolomics GWAS to robustly identify molecular disease markers. ..
  38. Finocchiaro G, Ito M, Tanaka K. Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver. J Biol Chem. 1987;262:7982-9 pubmed
    ..The pattern of substrate specificity for these enzymes determined using ETF as electron acceptor significantly differed from that determined using PMS. All of them were severely inhibited by (methylenecyclopropyl)acetyl-CoA. ..
  39. Kelly C, Hinsdale M, Wood P. Cloning and characterization of the mouse short-chain acyl-CoA dehydrogenase cDNA. Genomics. 1993;18:137-40 pubmed
    Short-chain acyl-CoA dehydrogenase (SCAD) is one of five homologous dehydrogenases that catalyze the first reaction in the beta-oxidation of fatty acids. As the name implies, the substrate for this enzyme is short-chain acyl-CoA (C4-C6)...
  40. Yang Z, Lantz P, Ibdah J. Post-mortem analysis for two prevalent beta-oxidation mutations in sudden infant death. Pediatr Int. 2007;49:883-7 pubmed
    ..The present data support post-mortem molecular analysis for the MCAD A985G and MTP G1528C prevalent mutations in cases of sudden and unexplained infant death associated with hepatic steatosis. ..
  41. Kovanen L, Saarikoski S, Haukka J, Pirkola S, Aromaa A, Lonnqvist J, et al. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Alcohol Alcohol. 2010;45:303-11 pubmed publisher
    ..04) and NPY Pro7 decreased (P = 0.01) the risk of alcohol dependence. ARNTL, ARNTL2, VIP and ADCYAP1 were indicated as having influence on alcohol use or abuse. The role of DRD2 and NPY on alcohol dependence was also supported. ..
  42. Vandamme M, De Backer J, De Backer T, Drieghe B, Devos D, Gevaert S. The spectrum of spontaneous coronary artery dissection: illustrated review of the literature. Acta Cardiol. 2017;72:599-609 pubmed publisher
    Spontaneous coronary artery dissection or SCAD is a rare and challenging disease that is increasingly diagnosed...
  43. Reijers J, Kallend D, Malone K, Jukema J, Wijngaard P, Burggraaf J, et al. MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216. Cardiovasc Drugs Ther. 2017;31:381-389 pubmed publisher
    ..a clinical trial in which 24 healthy volunteers (HV) and 24 patients with proven stable coronary artery disease (sCAD) received a single intravenous dose of MDCO-216, ranging 5-40 mg/kg...
  44. Nguyen T, Riggs C, Babovic Vuksanovic D, Kim Y, Carpenter J, Burghardt T, et al. Purification and characterization of two polymorphic variants of short chain acyl-CoA dehydrogenase reveal reduction of catalytic activity and stability of the Gly185Ser enzyme. Biochemistry. 2002;41:11126-33 pubmed
    Short chain acyl-CoA dehydrogenase (SCAD) is a homotetrameric flavoenzyme that catalyzes the first intramitochondrial step in the beta-oxidation of fatty acids...
  45. Attallah O, Karthikesalingam A, Holt P, Thompson M, Sayers R, Bown M, et al. Feature selection through validation and un-censoring of endovascular repair survival data for predicting the risk of re-intervention. BMC Med Inform Decis Mak. 2017;17:115 pubmed publisher
    ..as they both have concordance index and estimated AUC better than the Cox's model based on AIC, BIC, Lasso, and SCAD approaches. These models have p-values lower than 0...
  46. Englund A, Kovanen L, Saarikoski S, Haukka J, Reunanen A, Aromaa A, et al. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. J Circadian Rhythms. 2009;7:5 pubmed publisher
    ..049). Our findings support the view that relevant relationships between circadian clocks and the metabolic syndrome in humans exist. ..
  47. Ullrich H, Gori T. [Coronary Computed Tomography Angiography in Patients with Stable Coronary Artery Disease]. Dtsch Med Wochenschr. 2017;142:1604-1605 pubmed publisher
    The guidelines on the management of stable coronary artery disease (SCAD) recommend the use of coronary computed tomography angiography (CTA) in the process of diagnosing coronary artery disease in patients with low intermediate pre-test ..
  48. Pedersen C, Kølvraa S, Kølvraa A, Stenbroen V, Kjeldsen M, Ensenauer R, et al. The ACADS gene variation spectrum in 114 patients with short-chain acyl-CoA dehydrogenase (SCAD) deficiency is dominated by missense variations leading to protein misfolding at the cellular level. Hum Genet. 2008;124:43-56 pubmed publisher
    ..SCAD) deficiency is an inherited disorder of mitochondrial fatty acid oxidation associated with variations in the ACADS gene and variable clinical symptoms. In addition to rare ACADS inactivating variations, two common variations, c...
  49. Alzayer H, Bossard M, Ahsan S, Tsang M, Whitlock R, Sheth T. A Case of Spontaneous Coronary Artery Dissection Complicated by Free Wall Rupture. Can J Cardiol. 2017;33:1736.e13-1736.e15 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is an unusual and underdiagnosed cause of nonatherosclerotic acute coronary syndrome (ACS)...
  50. Dessein A, Fontaine M, Joncquel Chevalier Curt M, Briand G, Sechter C, Mention Mulliez K, et al. Fluxomic evidence for impaired contribution of short-chain acyl-CoA dehydrogenase to mitochondrial palmitate β-oxidation in symptomatic patients with ACADS gene susceptibility variants. Clin Chim Acta. 2017;471:101-106 pubmed publisher
    Despite ACADS (acyl-CoA dehydrogenase, short-chain) gene susceptibility variants (c.511C>T and c.625G>A) are considered to be non-pathogenic, encoded proteins are known to exhibit altered kinetics...
  51. Pelz J, Harms K, Metze M, Michalski D. Spontaneous cervical artery dissection is accompanied by a hypercoagulable state and simultaneous inflammatory condition. J Neurol. 2017;: pubmed publisher
    Spontaneous cervical artery dissections (sCAD) are often preceded by infections. However, existing data about inflammatory parameters remained inconsistent...
  52. Zhang Q, Li J, Wang D, Wang Y. Finding disagreement pathway signatures and constructing an ensemble model for cancer classification. Sci Rep. 2017;7:10044 pubmed publisher
    ..We compare the proposed method with other methods, such as Elastic SCAD and PPDMF, and estimate the classification performance...
  53. Nochi Z, Olsen R, Gregersen N. Short-chain acyl-CoA dehydrogenase deficiency: from gene to cell pathology and possible disease mechanisms. J Inherit Metab Dis. 2017;: pubmed publisher
    ..Accordingly, there is a worldwide discussion of the relationship of clinical manifestation to SCADD, and whether SCAD gene variants are disease associated at all...
  54. Giannini N, Ulivi L, Maccarrone M, Montano V, Orlandi G, Ferrari E, et al. Epidemiology and cerebrovascular events related to cervical and intracranial arteries dissection: the experience of the city of Pisa. Neurol Sci. 2017;38:1985-1991 pubmed publisher
    Spontaneous dissection of cervical arteries (sCAD) is a major cause of ischemic stroke in young patients, with an incidence varying from 1.7 to 3/100,000/year for extracranial internal carotid artery (ICAD) and 1 to 1...
  55. Camões F, Islinger M, Guimaraes S, Kilaru S, Schuster M, Godinho L, et al. New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes. Biochim Biophys Acta. 2015;1853:111-25 pubmed publisher
    ..Furthermore, we provide evidence that acyl-CoA dehydrogenases (ACADs) are bona fide peroxisomal proteins in fungi and mammals and together with acyl-CoA oxidases (ACOX) belong to the ..
  56. Jiang P, Song Y, Xu J, Ma Y, Tang X, Yao Y, et al. [Impact of platelet distribution width on the extent and long-term outcome of patients with stable coronary artery disease post percutaneous coronary intervention]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017;45:862-866 pubmed publisher
    ..in patients received percutaneous coronary artery intervention(PCI) because of stable coronary artery disease(SCAD)...
  57. Tweet M, Hayes S, Codsi E, Gulati R, Rose C, Best P. Spontaneous Coronary Artery Dissection Associated With Pregnancy. J Am Coll Cardiol. 2017;70:426-435 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is the most common cause of pregnancy-associated myocardial infarction and remains poorly characterized...
  58. Giurgiutiu D, Espinoza L, Wood T, DuPont B, Holden K. Persistent growth failure in Prader-Willi syndrome associated with short-chain acyl-CoA dehydrogenase gene variant. J Child Neurol. 2008;23:112-7 pubmed publisher
    ..Extensive laboratory investigations indicate that the short-chain acyl-CoA dehydrogenase gene variant is likely preventing or delaying the normal expression of the Prader-Willi syndrome phenotype...
  59. Shirao K, Okada S, Tajima G, Tsumura M, Hara K, Yasunaga S, et al. Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency. Hum Genet. 2010;127:619-28 pubmed publisher
    ..However, clinical significance of SCAD deficiency (SCADD) has been getting ambiguous, for some variants in the ACADS gene, which encodes the SCAD protein, has turned out to be widely prevailed among general populations...
  60. Vatanavicharn N, Liammongkolkul S, Sakamoto O, Sathienkijkanchai A, Wasant P. Phenotypic and mutation spectrums of Thai patients with isovaleric acidemia. Pediatr Int. 2011;53:990-4 pubmed publisher
    ..A65G and p.L247P, were identified. The present study provides additional knowledge on the genotype-phenotype of IVA, suggesting that IVD mutations in Asian populations are distinct from these in Western populations. ..
  61. Corydon M, Andresen B, Bross P, Kjeldsen M, Andreasen P, Eiberg H, et al. Structural organization of the human short-chain acyl-CoA dehydrogenase gene. Mamm Genome. 1997;8:922-6 pubmed
    ..aciduria in patients, we have determined the sequence of the complete coding portion of the human SCAD gene (ACADS) and all of the intron-exon boundaries. The SCAD gene is approximately 13 kb in length and consists of 10 exons...