ACAT1

Summary

Gene Symbol: ACAT1
Description: acetyl-CoA acetyltransferase 1
Alias: ACAT, MAT, THIL, acetyl-CoA acetyltransferase, mitochondrial, acetoacetyl Coenzyme A thiolase, acetoacetyl-CoA thiolase, acetyl-Coenzyme A acetyltransferase 1, mitochondrial acetoacetyl-CoA thiolase, testicular tissue protein Li 198
Species: human
Products:     ACAT1

Top Publications

  1. Kang J, Cheng B, Jiang L. [PPARγ signal transduction pathway in the foam cell formation induced by visfatin]. Sheng Li Xue Bao. 2010;62:427-32 pubmed
    ..in the expression of ATP binding cassette transporter A1 (ABCA1) and acyl-CoA:cholesterol acyltransferase 1 (ACAT1) induced by visfatin and to discuss the mechanism of foam cell formation induced by visfatin...
  2. Yoshinaka Y, Shibata H, Kobayashi H, Kuriyama H, Shibuya K, Tanabe S, et al. A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice. Atherosclerosis. 2010;213:85-91 pubmed publisher
    Acyl-coenzyme A:cholesterol O-acyltransferase-1 (ACAT-1) plays an essential role in macrophage foam cell formation and progression of atherosclerosis...
  3. Ohta T, Takata K, Katsuren K, Fukuyama S. The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects. Biochim Biophys Acta. 2004;1682:56-62 pubmed
    Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis. Two isoforms of ACAT have been reported (ACAT-1 and ACAT-2)...
  4. Chen J, Zhao X, Yang L, Hu G, Lu M, Xiong Y, et al. RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform. Cell Res. 2008;18:921-36 pubmed publisher
    We have previously reported that the human ACAT1 gene produces a chimeric mRNA through the interchromosomal processing of two discontinuous RNAs transcribed from chromosomes 1 and 7...
  5. Li Q, Bai H, Fan P. [Analysis of acyl-coenzyme A: cholesterol acyltransferase 1 polymorphism in patients with endogenous hypertriglyceridemia in Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008;25:206-10 pubmed
    To investigate the polymorphism of acyl-coenzyme A: cholesterol acyltransferase 1(ACAT1) gene and its relationship with endogenous hypertriglyceridemia (HTG) in Chinese population...
  6. Wu D, Yin R, Aung L, Li Q, Yan T, Zeng X, et al. Sex-specific association of ACAT-1 rs1044925 SNP and serum lipid levels in the hypercholesterolemic subjects. Lipids Health Dis. 2012;11:9 pubmed publisher
    Acyl-CoA:cholesterol acyltransferase (ACAT) is a key enzyme in cellular cholesterol homeostasis and in atherosclerosis...
  7. Fukao T, Yamaguchi S, Kano M, Orii T, Fujiki Y, Osumi T, et al. Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency. J Clin Invest. 1990;86:2086-92 pubmed
    ..These results suggest that different mechanisms are involved in the enzyme defects in the four patients. ..
  8. Liang Y, Yang X, Ma L, Cai X, Wang L, Yang C, et al. Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells. Acta Biochim Biophys Sin (Shanghai). 2013;45:220-8 pubmed publisher
    ..Acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) promotes accumulation of cholesterol ester in macrophages, thereby resulting in the foam cell formation, a ..
  9. Sakashita N, Chang C, Lei X, Fujiwara Y, Takeya M, Chang T. Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity. J Lipid Res. 2010;51:1263-72 pubmed publisher
    b>ACAT1 is normally a resident enzyme in the endoplasmic reticulum (ER). We previously showed that treating macrophages with denatured LDL causes a large increase in ER-derived, ACAT1-positive vesicles...
  10. Kanome T, Watanabe T, Nishio K, Takahashi K, Hongo S, Miyazaki A. Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. Hypertens Res. 2008;31:1801-10 pubmed publisher
    ..Acyl-CoA:cholesterol acyltransferase-1 (ACAT1) converts intracellular free cholesterol into cholesterol ester (CE) for storage in lipid droplets, and promotes ..

Detail Information

Publications62

  1. Kang J, Cheng B, Jiang L. [PPARγ signal transduction pathway in the foam cell formation induced by visfatin]. Sheng Li Xue Bao. 2010;62:427-32 pubmed
    ..in the expression of ATP binding cassette transporter A1 (ABCA1) and acyl-CoA:cholesterol acyltransferase 1 (ACAT1) induced by visfatin and to discuss the mechanism of foam cell formation induced by visfatin...
  2. Yoshinaka Y, Shibata H, Kobayashi H, Kuriyama H, Shibuya K, Tanabe S, et al. A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice. Atherosclerosis. 2010;213:85-91 pubmed publisher
    Acyl-coenzyme A:cholesterol O-acyltransferase-1 (ACAT-1) plays an essential role in macrophage foam cell formation and progression of atherosclerosis...
  3. Ohta T, Takata K, Katsuren K, Fukuyama S. The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects. Biochim Biophys Acta. 2004;1682:56-62 pubmed
    Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis. Two isoforms of ACAT have been reported (ACAT-1 and ACAT-2)...
  4. Chen J, Zhao X, Yang L, Hu G, Lu M, Xiong Y, et al. RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform. Cell Res. 2008;18:921-36 pubmed publisher
    We have previously reported that the human ACAT1 gene produces a chimeric mRNA through the interchromosomal processing of two discontinuous RNAs transcribed from chromosomes 1 and 7...
  5. Li Q, Bai H, Fan P. [Analysis of acyl-coenzyme A: cholesterol acyltransferase 1 polymorphism in patients with endogenous hypertriglyceridemia in Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008;25:206-10 pubmed
    To investigate the polymorphism of acyl-coenzyme A: cholesterol acyltransferase 1(ACAT1) gene and its relationship with endogenous hypertriglyceridemia (HTG) in Chinese population...
  6. Wu D, Yin R, Aung L, Li Q, Yan T, Zeng X, et al. Sex-specific association of ACAT-1 rs1044925 SNP and serum lipid levels in the hypercholesterolemic subjects. Lipids Health Dis. 2012;11:9 pubmed publisher
    Acyl-CoA:cholesterol acyltransferase (ACAT) is a key enzyme in cellular cholesterol homeostasis and in atherosclerosis...
  7. Fukao T, Yamaguchi S, Kano M, Orii T, Fujiki Y, Osumi T, et al. Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency. J Clin Invest. 1990;86:2086-92 pubmed
    ..These results suggest that different mechanisms are involved in the enzyme defects in the four patients. ..
  8. Liang Y, Yang X, Ma L, Cai X, Wang L, Yang C, et al. Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells. Acta Biochim Biophys Sin (Shanghai). 2013;45:220-8 pubmed publisher
    ..Acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) promotes accumulation of cholesterol ester in macrophages, thereby resulting in the foam cell formation, a ..
  9. Sakashita N, Chang C, Lei X, Fujiwara Y, Takeya M, Chang T. Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity. J Lipid Res. 2010;51:1263-72 pubmed publisher
    b>ACAT1 is normally a resident enzyme in the endoplasmic reticulum (ER). We previously showed that treating macrophages with denatured LDL causes a large increase in ER-derived, ACAT1-positive vesicles...
  10. Kanome T, Watanabe T, Nishio K, Takahashi K, Hongo S, Miyazaki A. Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. Hypertens Res. 2008;31:1801-10 pubmed publisher
    ..Acyl-CoA:cholesterol acyltransferase-1 (ACAT1) converts intracellular free cholesterol into cholesterol ester (CE) for storage in lipid droplets, and promotes ..
  11. Yamamoto K, Tajima Y, Hasegawa A, Takahashi Y, Kojima M, Watanabe R, et al. Contrasting effects of stanniocalcin-related polypeptides on macrophage foam cell formation and vascular smooth muscle cell migration. Peptides. 2016;82:120-127 pubmed publisher
    ..Expression of acyl-CoA:cholesterol acyltransferase-1 (ACAT1) was significantly suppressed by STC1(18-247) but stimulated by STC2(80-100) and STC2(85-99)...
  12. Fukao T, Yamaguchi S, Scriver C, Dunbar G, Wakazono A, Kano M, et al. Molecular studies of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in the two original families. Hum Mutat. 1993;2:214-20 pubmed
    ..The JB allele associates with Dutch ancestry (no consanguinity) and the JM allele with Chilean ancestry (distant consanguinity). ..
  13. Kellner Weibel G, Luke S, Rothblat G. Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1. Atherosclerosis. 2003;171:235-43 pubmed
    ..Treatment with an acyl coenzyme-A:cholesterol acyltransferase (ACAT) inhibitor, in the absence of extracellular acceptors, produced hydrolysis of stored esterified cholesterol (EC) ..
  14. Sewell A, Herwig J, Wiegratz I, Lehnert W, Niederhoff H, Song X, et al. Mitochondrial acetoacetyl-CoA thiolase (beta-ketothiolase) deficiency and pregnancy. J Inherit Metab Dis. 1998;21:441-2 pubmed
  15. Fukao T, Yamaguchi S, Orii T, Hashimoto T. Molecular basis of beta-ketothiolase deficiency: mutations and polymorphisms in the human mitochondrial acetoacetyl-coenzyme A thiolase gene. Hum Mutat. 1995;5:113-20 pubmed
    ..A correlation between clinical phenotype and genotype in T2 deficiency seems unlikely. ..
  16. Rajapakse D, Peterson K, Mishra S, Wistow G. Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. Exp Cell Res. 2017;361:333-341 pubmed publisher
    ..AMD) associated EFEMP1/Fibulin3 (Fib3); and levels of acyl-coenzyme A (CoA): cholesterol acyltransferases (ACAT) ACAT1, ACAT2 and Apolipoprotein B (ApoB) in ARPE-19 cells cultured in serum-supplemented and serum-free media...
  17. Abbaszadeh H, Peyvandi A, Sadeghi Y, Safaei A, Zamanian Azodi M, Khoramgah M, et al. Er:YAG Laser and Cyclosporin A Effect on Cell Cycle Regulation of Human Gingival Fibroblast Cells. J Lasers Med Sci. 2017;8:143-149 pubmed publisher
    ..YWHAZ, VCP, HNRNPU, YWHAE, UBA52, CLTC, FUS and IGHG1 as key proteins while similar analysis revealed that ACAT1, CTSD, ALDOA, ANXA2, PRDX1, LGALS3, ARHGDI and EEF1A1 are the crucial proteins related to the effect of drug...
  18. Tsintzas K, Stephens F, Snijders T, Wall B, Cooper S, Mallinson J, et al. Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Exp Gerontol. 2017;93:36-45 pubmed publisher
    ..indicating increased inflammatory response (IL6, IkBalpha, CREB1) and impaired fat metabolism and TCA cycle (LPL, ACAT1, SUCLG1) in older compared with younger individuals...
  19. Hu L, Li J, Cai H, Yao W, Xiao J, Li Y, et al. Avasimibe: A novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles. Antiviral Res. 2017;148:5-14 pubmed publisher
    ..Our results showed that avasimibe, an inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), exhibited marked pan-genotypic inhibitory activity and superior inhibition against HCV when combined with DAAs...
  20. Raman J, Fritz T, Gerken T, Jamison O, Live D, Liu M, et al. The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. J Biol Chem. 2008;283:22942-51 pubmed publisher
    ..Local sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not. ..
  21. Lo Y, Lin S, Chang S, Chan C, Lyu K, Chang J, et al. Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer. J Cell Mol Med. 2015;19:744-59 pubmed publisher
    ..Mitochondrial proteins such as acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) have not been reported with the roles on the formation of doxorubicin resistance ..
  22. Wojcik M, Wierenga K, Rodan L, Sahai I, Ferdinandusse S, Genetti C, et al. Beta-Ketothiolase Deficiency Presenting with Metabolic Stroke After a Normal Newborn Screen in Two Individuals. JIMD Rep. 2017;: pubmed publisher
    ..It results from biallelic pathogenic variants in the ACAT1 gene, encoding mitochondrial beta-ketothiolase...
  23. Maurer G, Brucker D, Bähr O, Harter P, Hattingen E, Walenta S, et al. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer. 2011;11:315 pubmed publisher
    ..dehydrogenase 1 and 2 (BDH1 and 2), 3-oxoacid-CoA transferase 1 (OXCT1) and acetyl-CoA acetyltransferase 1 (ACAT1) were expressed at the mRNA and protein level in all glioma cell lines...
  24. Davidson M. Therapies targeting exogenous cholesterol uptake: new insights and controversies. Curr Atheroscler Rep. 2011;13:95-100 pubmed publisher
    ..transcription factors such as LXR that affect sterol transporters NPC1L1, ABCG5/G8, and ABCG1, and enzymes such as ACAT-2...
  25. Saadane A, Mast N, Dao T, Ahmad B, Pikuleva I. Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells. J Biol Chem. 2016;291:20427-39 pubmed publisher
    ..OS were also found to express the cholesterol-esterifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not lecithin-cholesterol acyltransferase (LCAT), and to differ from humans in retinal expression of ACAT1...
  26. Fukao T, Yamaguchi S, Orii T, Osumi T, Hashimoto T. Molecular basis of 3-ketothiolase deficiency: identification of an AG to AC substitution at the splice acceptor site of intron 10 causing exon 11 skipping. Biochim Biophys Acta. 1992;1139:184-8 pubmed
    ..When the PCR-amplified genomic fragments around exon 11 were sequenced, an AG to AC mutation at the 3' splice site of intron 10 was detected. This mutation is presumed to be responsible for exon 11 skipping. ..
  27. Guo Z, Chang C, Chang T. Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1. Biochemistry. 2007;46:10063-71 pubmed
    Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a resident enzyme in the endoplasmic reticulum. ACAT1 is a homotetrameric protein and contains nine transmembrane domains (TMDs)...
  28. Fukao T, Matsuo N, Zhang G, Urasawa R, Kubo T, Kohno Y, et al. Single base substitutions at the initiator codon in the mitochondrial acetoacetyl-CoA thiolase (ACAT1/T2) gene result in production of varying amounts of wild-type T2 polypeptide. Hum Mutat. 2003;21:587-92 pubmed
    ..in a Japanese patient (Patient GK30) with mitochondrial acetoacetyl-CoA thiolase (T2) gene deficiency (ACAT1 deficiency); c.149delC was on the other allele...
  29. Wakazono A, Fukao T, Yamaguchi S, Hori T, Orii T, Lambert M, et al. Molecular, biochemical, and clinical characterization of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in two further patients. Hum Mutat. 1995;5:34-42 pubmed
    ..Cotransfection of two cDNAs containing N158D and T297M suggested that heterotetramer formation reduces residual activity in GK11 cells. ..
  30. Bzoma B, Debska Slizien A, Dudziak M, Raczynska K, Slizień W, Brylowska A, et al. [Genetic predisposition to systemic complications of arterial hypertension in maintenance haemodialysis patients]. Pol Merkur Lekarski. 2008;25:209-16 pubmed
    ..Direct ophtalmoscopy seems to be an insufficient method in the estimation of the systemic complications of hypertension in haemodialysed patients. ..
  31. An S, Jang Y, Park J, Kwon B, Paik Y, Jeong T. Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes. Exp Mol Med. 2008;40:407-17 pubmed
    ..the mechanism of spontaneous cholesterol efflux induced by acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition, and how an alteration of cholesterol metabolism in macrophages impacts on that in HepG2 cells...
  32. Nakazawa T, Miyanoki Y, Urano Y, Uehara M, Saito Y, Noguchi N. Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis. J Steroid Biochem Mol Biol. 2017;169:69-76 pubmed publisher
    ..Esterification of 24S-OHC followed by lipid droplet (LD) formation due to acyl-CoA:cholesterol acyltransferase 1 (ACAT1) are key events in 24S-OHC-induced cell death in atRA-treated SH-SY5Y cells as demonstrated by inhibition of cell ..
  33. Davis W. The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism. Biochim Biophys Acta. 2014;1841:168-79 pubmed publisher
    ..an altered bilayer distribution of the sphingolipid ceramide that inhibited acylCoA:cholesterol acyltransferase (ACAT) activity and cholesterol esterification...
  34. Thümmler S, Dupont D, Acquaviva C, Fukao T, De Ricaud D. Different clinical presentation in siblings with mitochondrial acetoacetyl-CoA thiolase deficiency and identification of two novel mutations. Tohoku J Exp Med. 2010;220:27-31 pubmed
    ..In conclusion, the siblings with the same T2 gene mutations present different clinical severity. Diagnostic testing for asymptomatic siblings is important in the management of T2-deficient families. ..
  35. Yang B, Smith D. In Silico Absorption Analysis of Valacyclovir in Wildtype and Pept1 Knockout Mice Following Oral Dose Escalation. Pharm Res. 2017;34:2349-2361 pubmed publisher
    ..Simulations were conducted using a mechanistic advanced compartmental absorption and transit (ACAT) model implemented in GastroPlus™...
  36. Ohmoto T, Nishitsuji K, Yoshitani N, Mizuguchi M, Yanagisawa Y, Saito H, et al. K604, a specific acyl‑CoA:cholesterol acyltransferase 1 inhibitor, suppresses proliferation of U251‑MG glioblastoma cells. Mol Med Rep. 2015;12:6037-42 pubmed publisher
    ..Increased levels of cholesteryl ester and simultaneous expression of acyl‑CoA:cholesterol acyltransferase 1 (ACAT1) in tumor cells indicated that cholesterol esterification is critical to tumor growth...
  37. Wu D, Yin R, Cao X, Chen W. Association between single nucleotide polymorphism rs1044925 and the risk of coronary artery disease and ischemic stroke. Int J Mol Sci. 2014;15:3546-59 pubmed publisher
    The present study was performed to clarify the association between the acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) single nucleotide polymorphism (SNP) rs1044925 and the risk of coronary artery disease (CAD) and ischemic stroke (IS) ..
  38. Su Y, Dove D, Major A, Hasty A, Boone B, Linton M, et al. Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. Circulation. 2005;111:2373-81 pubmed
    Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein E (apoE) have been implicated in regulating cellular cholesterol homeostasis and therefore play critical roles in foam cell formation...
  39. Hai Q, Ritchey B, Robinet P, Alzayed A, Brubaker G, Zhang J, et al. Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant. Arterioscler Thromb Vasc Biol. 2018;38:83-91 pubmed publisher
    ..the Soat1 (sterol O-acyltransferase 1) gene, encoding Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), which esterifies free cholesterol...
  40. Sakurai S, Fukao T, Haapalainen A, Zhang G, Yamada K, Lilliu F, et al. Kinetic and expression analyses of seven novel mutations in mitochondrial acetoacetyl-CoA thiolase (T2): identification of a Km mutant and an analysis of the mutational sites in the structure. Mol Genet Metab. 2007;90:370-8 pubmed
    ..The probable effect of the other mutations on the T2 tertiary structure was also evaluated. ..
  41. Xu T, Cardoso F, Pineda A, Trevisi E, Shen X, Rosa F, et al. Grain challenge affects systemic and hepatic molecular biomarkers of inflammation, stress, and metabolic responses to a greater extent in Holstein than Jersey cows. J Dairy Sci. 2017;100:9153-9162 pubmed publisher
    ..Genes related to ketogenesis (HMGCS2 and ACAT1) were upregulated in Jerseys, and gluconeogenic genes (PDK4 and PCK1) were upregulated in Holstein cows fed HIG, ..
  42. Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, et al. Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Circ Res. 2009;105:500-10 pubmed publisher
    ..Macrophage foam cell formation, characterized by cholesterol ester accumulation, is modulated by scavenger receptor class A (SR-A), acyl-coenzyme A:cholesterol acyltransferase (ACAT)1, and ATP-binding cassette transporter (ABC)A1.
  43. Yin R, Wu D, Wu J, Cao X, Aung L, Miao L, et al. Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels. Int J Biol Sci. 2012;8:685-96 pubmed publisher
    ..Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaⅡ, hepatic lipase gene (LIPC) -250G>A, endothelial ..
  44. Saraon P, Cretu D, Musrap N, Karagiannis G, Batruch I, Drabovich A, et al. Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression. Mol Cell Proteomics. 2013;12:1589-601 pubmed publisher
    ..After analyzing the remaining enzymes of this pathway (ACAT1, BDH1, HMGCL, and OXCT1), we observed increased expression of these proteins in the LNCaP-SF cells, which was ..
  45. Fan J, Shan C, Kang H, Elf S, Xie J, Tucker M, et al. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol Cell. 2014;53:534-48 pubmed publisher
    ..Moreover, we identified mitochondrial ACAT1 and SIRT3 as the upstream acetyltransferase and deacetylase, respectively, of PDHA1 and PDP1, while knockdown of ..
  46. Su L, Li X, Lin R, Sheng H, Feng Z, Liu L. Clinical and molecular analysis of 6 Chinese patients with isoleucine metabolism defects: identification of 3 novel mutations in the HSD17B10 and ACAT1 gene. Metab Brain Dis. 2017;32:2063-2071 pubmed publisher
    ..83_84delAT, c.1006-1G > C, and two novel mutations: p.Thr277Pro and c.121-3C > G were identified in the ACAT1 gene of β-KT deficiency patients...
  47. Gobeau N, Stringer R, De Buck S, Tuntland T, Faller B. Evaluation of the GastroPlus™ Advanced Compartmental and Transit (ACAT) Model in Early Discovery. Pharm Res. 2016;33:2126-39 pubmed publisher
    ..exposure predictions obtained early in drug discovery with a generic GastroPlus Advanced Compartmental And Transit (ACAT) model based on the in vivo intravenous blood concentration-time profile, in silico properties (lipophilicity, pKa) ..
  48. Fukao T, Song X, Mitchell G, Yamaguchi S, Sukegawa K, Orii T, et al. Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases. Pediatr Res. 1997;42:498-502 pubmed
    ..The relative amounts of T2 and SCOT were similar in all tissues except for liver (T2 > > SCOT) and brain (SCOT > T2). The observed distribution of SCOT, T2, and CT is consistent with current views of their physiologic roles. ..
  49. Fan J, Lin R, Xia S, Chen D, Elf S, Liu S, et al. Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth. Mol Cell. 2016;64:859-874 pubmed publisher
    Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) regulates pyruvate dehydrogenase complex (PDC) by acetylating pyruvate dehydrogenase (PDH) and PDH phosphatase...
  50. Wang Y, Wang Y, Ma Y, Fu Z, Yang Y, Ma X, et al. ACAT-1 gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a case-control study. Oncotarget. 2017;8:89055-89063 pubmed publisher
    Several studies suggest an important role of Acyl-CoA: cholesterol acyltransferase-1(ACAT-1) in the development of atherosclerosis...
  51. Pelletier R, Akpovi C, Chen L, Vitale M. Cholesterol metabolism and Cx43, Cx46, Cx50 gap junction protein expression and localisation in normal and diabetic and obese ob/ob and db/db mouse testes. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00215.2017 pubmed publisher
    ..In tubules, only ACAT-1 and ACAT-2 protein levels significantly decreased in ob/ob not in db/db compared to WT and cholesterol ..
  52. Zhu M, Zhao X, Chen J, Xu J, Hu G, Guo D, et al. ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration. Acta Biochim Biophys Sin (Shanghai). 2015;47:951-9 pubmed publisher
    Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a key enzyme exclusively using free cholesterols as the substrates in cell and is involved in the cellular cholesterol homeostasis...
  53. Hu G, Chen J, Zhao X, Xu J, Guo D, Lu M, et al. Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene. Cell Res. 2013;23:1007-24 pubmed publisher
    ..Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a key enzyme involved in cellular cholesterol homeostasis. The 4...
  54. Yin R, Wu D, Aung L, Yan T, Cao X, Long X, et al. Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels. Int J Mol Sci. 2012;13:12062-81 pubmed publisher
    ..Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII hepatic lipase gene (LIPC) -250G > A, endothelial ..
  55. Yang Y, Wang Y, Yang X, Wang Z, Lian Y, Yang Y, et al. Specific Kv1.3 blockade modulates key cholesterol-metabolism-associated molecules in human macrophages exposed to ox-LDL. J Lipid Res. 2013;54:34-43 pubmed publisher
    ..scavenger receptor class A (SR-A), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), CD36, ACAT1, ABCA1, ABCG1, and scavenger receptor class B type I, can modulate cholesterol metabolism in the transformation ..
  56. Kunze M, Neuberger G, Maurer Stroh S, Ma J, Eck T, Braverman N, et al. Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7. J Biol Chem. 2011;286:45048-62 pubmed publisher
    ..This additional information on PTS2 signals was used to generate a PTS2 prediction algorithm that enabled us to identify novel PTS2 signals within human proteins and to describe KChIP4 as a novel peroxisomal protein. ..
  57. Mitra R, Le T, Gorjala P, Goodman O. Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5. BMC Cancer. 2017;17:631 pubmed publisher
    ..Our results indicate that DGAT1, ABHD5, ACAT1 and ATGL are overexpressed in prostate cancer cells compared to PBMCs and of these overexpressed genes, DGAT1 and ..
  58. Zhu Z, Jia J, Zhang X, Wang Y, Wang D. Asymmetric dimethylarginine upregulates the expression of ACAT-1 in THP-1 macrophage-derived foam cells. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:2613-8 pubmed
    To investigate the effects of asymmetric dimethylarginine (ADMA) on ACAT-1 expression and cholesterol content in THP-1-derived macrophages and foam cells...
  59. Zhang G, Fukao T, Sakurai S, Yamada K, Michael Gibson K, Kondo N. Identification of Alu-mediated, large deletion-spanning exons 2-4 in a patient with mitochondrial acetoacetyl-CoA thiolase deficiency. Mol Genet Metab. 2006;89:222-6 pubmed
    ..Cloning and sequencing long range PCR products revealed a 6.4kb deletion. Alu element-mediated unequal homologous recombination between an Alu-Sx in intron 1 and another Alu-Y in intron 4 appears to be responsible for this deletion. ..
  60. Middleton B, Bartlett K, Romanos A, Gomez Vazquez J, Conde C, Cannon R, et al. 3-Ketothiolase deficiency. Eur J Pediatr. 1986;144:586-9 pubmed
    ..In one patient the organic aciduria was very subtle and was masked during the presence of ketosis, but it was clarified by an isoleucine load after recovery from ketosis. ..
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