ADD3

Summary

Gene Symbol: ADD3
Description: adducin 3
Alias: ADDL, CPSQ3, gamma-adducin, adducin 3 (gamma), adducin-like protein 70
Species: human

Top Publications

  1. ncbi The mouse adducin gene family: alternative splicing and chromosomal localization
    S P Suriyapperuma
    Yale University School of Medicine, 333 Cedar Street, WWW 403, New Haven, Connecticut 06510, USA
    Mamm Genome 11:16-23. 2000
  2. pmc Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:1971-6. 2009
  3. pmc Adducins regulate remodeling of apical junctions in human epithelial cells
    Nayden G Naydenov
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Mol Biol Cell 21:3506-17. 2010
  4. doi Common genetic variants regulating ADD3 gene expression alter biliary atresia risk
    Guo Cheng
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Hepatol 59:1285-91. 2013
  5. pmc Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia
    Ellen A Tsai
    Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Hum Genet 133:235-43. 2014
  6. pmc Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2
    Maria Mercè Garcia-Barceló
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Hum Mol Genet 19:2917-25. 2010
  7. pmc Adducin: Ca++-dependent association with sites of cell-cell contact
    H W Kaiser
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    J Cell Biol 109:557-69. 1989
  8. doi Knockdown of Add3 Impairs the Myogenic Response of Renal Afferent Arterioles and Middle Cerebral Arteries
    Fan Fan
    University of Mississippi Medical Center
    Am J Physiol Renal Physiol . 2016
  9. doi Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder
    A W Charney
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY, USA
    Transl Psychiatry 7:e993. 2017
  10. pmc RNA sequencing of cancer reveals novel splicing alterations
    Jeyanthy Eswaran
    McCormick Genomic and Proteomics Center, The George Washington University, Washington, District of Columbia 20037, USA
    Sci Rep 3:1689. 2013

Scientific Experts

Detail Information

Publications86

  1. ncbi The mouse adducin gene family: alternative splicing and chromosomal localization
    S P Suriyapperuma
    Yale University School of Medicine, 333 Cedar Street, WWW 403, New Haven, Connecticut 06510, USA
    Mamm Genome 11:16-23. 2000
    ..We also report here the localization of the gene encoding gamma adducin (Add3) to murine Chr 19, in a region that shows conserved synteny with human Chr 10.
  2. pmc Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:1971-6. 2009
    ..We report here the existence of a protective mechanism that naturally shields synapses against ADDL-induced deterioration. Synapse pathology was investigated in mature cultures of hippocampal neurons...
  3. pmc Adducins regulate remodeling of apical junctions in human epithelial cells
    Nayden G Naydenov
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Mol Biol Cell 21:3506-17. 2010
    ..These findings suggest novel roles for adducins in stabilization of epithelial junctions and regulation of junctional remodeling...
  4. doi Common genetic variants regulating ADD3 gene expression alter biliary atresia risk
    Guo Cheng
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Hepatol 59:1285-91. 2013
    ..2 region encompassing ADD3 and XPNPEP1 genes, which was replicated in Chinese and Thai populations...
  5. pmc Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia
    Ellen A Tsai
    Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Hum Genet 133:235-43. 2014
    ..2 (hg18) genomic region. This signal was upstream of two genes, XPNPEP1 and ADD3, both expressed in intrahepatic bile ducts...
  6. pmc Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2
    Maria Mercè Garcia-Barceló
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Hum Mol Genet 19:2917-25. 2010
    ..94 x 10(-9). The identification of putative BA susceptibility loci not only opens new fields of investigation into the mechanisms underlying BA but may also provide new clues for the development of preventive and curative strategies...
  7. pmc Adducin: Ca++-dependent association with sites of cell-cell contact
    H W Kaiser
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    J Cell Biol 109:557-69. 1989
    ....
  8. doi Knockdown of Add3 Impairs the Myogenic Response of Renal Afferent Arterioles and Middle Cerebral Arteries
    Fan Fan
    University of Mississippi Medical Center
    Am J Physiol Renal Physiol . 2016
    ..Transfer of a region of chromosome 1 containing gamma-adducin (Add3) from Brown Norway rats rescues the vascular dysfunction and the development of renal disease...
  9. doi Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder
    A W Charney
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY, USA
    Transl Psychiatry 7:e993. 2017
    ..28 × 10-8) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1)...
  10. pmc RNA sequencing of cancer reveals novel splicing alterations
    Jeyanthy Eswaran
    McCormick Genomic and Proteomics Center, The George Washington University, Washington, District of Columbia 20037, USA
    Sci Rep 3:1689. 2013
    ..We validated the presence of novel hybrid isoforms of critical molecules like CDK4, LARP1, ADD3, and PHLPP2...
  11. pmc MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells
    Sandhya B Rani
    Corresponding Author Anjali Shiras, MSc, PhD, Scientist F, National Centre for Cell Science NCCS, NCCS Complex, University of Pune Campus, Ganeshkhind, Pune 411007, Maharashtra, India
    Neuro Oncol 15:1302-16. 2013
    ..MicroRNAs (miRNAs) are increasingly being recognized as being involved in cancer development and progression in gliomas...
  12. ncbi The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease
    Susan M Catalano
    Department of Alzheimer s Research, Merck Research Laboratories, West Point, PA 19486, USA
    Curr Top Med Chem 6:597-608. 2006
    ..These studies provide the basis for an alternate, ADDL-based, view of the Abeta cascade hypothesis and accounts for the disconnect between plaque burden and cognitive ..
  13. doi Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011
    L Olsson
    Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
    Leukemia 28:302-10. 2014
    ..Of these, deletions/uniparental isodisomies of ADD3, ATP10A, EBF1, IKZF1, PAN3, RAG1, SPRED1 and TBL1XR1 were significantly more common in B-cell precursor ALL ..
  14. pmc Mutations in γ adducin are associated with inherited cerebral palsy
    Michael C Kruer
    Sanford Children s Health Research Center, Sioux Falls, SD
    Ann Neurol 74:805-14. 2013
    ....
  15. doi Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers
    Yuta Ishizuka
    Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurochem Int 76:114-21. 2014
    ..SAHA markedly increased the acetylation of histone proteins, and it simultaneously attenuated the ADDL-induced decrease in drebrin cluster density...
  16. pmc Association between single nucleotide polymorphisms in the ADD3 gene and susceptibility to biliary atresia
    Shuaidan Zeng
    Zhuhai Campus of Zunyi Medical College, Zhuhai, Guangdong, China Department of General Surgery, Shenzhen Children s Hospital, Shenzhen, Guangdong, China
    PLoS ONE 9:e107977. 2014
    Based on the results of previous studies, the ADD3 gene, located in the 10q24.2 region, may be a susceptibility gene of biliary atresia (BA)...
  17. doi Genome-wide association studies in biliary atresia
    Mylarappa Ningappa
    Department of Surgery, Hillman Center for Pediatric Transplantation, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center UPMC, Pittsburgh, PA, USA
    Wiley Interdiscip Rev Syst Biol Med 7:267-73. 2015
    ..ribosylation factor 6, or ARF6) or a greater expression in fetal liver than in adult liver (adducin 3 or ADD3)...
  18. ncbi Co-expression of Cytoskeletal Protein Adducin 3 and CD133 in Neurospheres and a Temozolomide-resistant Subclone of Glioblastoma
    Ming Wai Poon
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, R O C
    Anticancer Res 35:6487-95. 2015
    Glioma stem cells are associated for temozolomide-resistance in glioblastoma. Adducin 3 (ADD3) is a cytoskeletal protein associated with chemoresistance but its role in glioblastoma has not been investigated.
  19. doi ADDing a piece to the puzzle of cognition in schizophrenia
    Marta Bosia
    Universita Vita Salute San Raffaele, Milan, Italy Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy Electronic address
    Eur J Med Genet 59:26-31. 2016
    ..we tested 342 patients with schizophrenia for three common adducins genetic variants, ADD1 rs4961, ADD2 rs4984 and ADD3 rs3731566, reported to have significant effects on circulatory system in humans...
  20. pmc Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish
    Vivian Tang
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia Research Institute Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    J Pediatr Gastroenterol Nutr 63:524-530. 2016
    ..Adducin 3 (ADD3) and X-prolyl aminopeptidase 1 (XPNPEP1) are 2 genes previously identified in genome-wide association studies as ..
  21. pmc Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease
    Silke Herzer
    Department of Cellular and Molecular Pathology, German Cancer Research Center, 69120, Heidelberg, Germany
    Acta Neuropathol Commun 4:103. 2016
    ..We furthermore demonstrate a molecular mechanism explaining how gangliosides mediate ADDL-related toxic effects on IR of murine neurons...
  22. ncbi Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease
    Xiao Dong Shi
    Jiangsu Province Key Laboratory of Anesthesiology and
    J Neurosci 36:11959-11973. 2016
    ..and synthesize four candidate peptides (Pep21, Pep25, Pep32, and Pep63) that might be able to block the EphB2-ADDL interaction. Among them, Pep63 was found to be the most effective at inhibiting the binding between EphB2 and ADDLs...
  23. doi Characterisation of the Genomic Landscape of CRLF2-rearranged Acute Lymphoblastic Leukemia
    Lisa J Russell
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Genes Chromosomes Cancer . 2016
    ..001), BTG1 (11/35, 31% v 10/108, 9%, P =0.004) and ADD3 deletions (9/19, 47% v 5/38, 13%, P =0.008)...
  24. pmc Genetic basis of the impaired renal myogenic response in FHH rats
    Marilyn Burke
    Dept of Pharmacology and Toxicology, Univ of Mississippi Medical Center, 2500 North State St Jackson, MS 39216, USA
    Am J Physiol Renal Physiol 304:F565-77. 2013
    ..4-Mbp region of FHH rats revealed amino acid-altering variants in the exons of three genes: Add3, Rbm20, and Soc-2...
  25. pmc Aβ oligomers-induced toxicity is attenuated in cells cultured with NbActiv4™ medium
    Yan Zhou
    Northwestern University Interdepartmental Neuroscience Program, 320 East Superior St, Searle 5 474, Chicago, IL 60611, USA
    Neurotox Res 22:335-44. 2012
    ..We aimed to investigate the effect of this novel medium on ADDL-induced toxicity. We found that ADDL-induced ROS was attenuated in cells cultured with NbActiv4™...
  26. pmc Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols
    Jason Pitt
    Department of Neurobiology, Northwestern University, Evanston, Illinois, USA
    FASEB J 27:199-207. 2013
    ..With respect to neuroprotection, DCI greatly enhances the ability of insulin to prevent ADDL-induced synapse damage (EC(50) of 90 nM)...
  27. pmc Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction
    Jörg van den Boom
    Department of Neuropathology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Am J Pathol 163:1033-43. 2003
    ..that the transcript levels of nine of the selected genes (COL4A2, FOXM1, MGP, TOP2A, CENPF, IGFBP4, VEGFA, ADD3, and CAMK2G) differed significantly in WHO grade II astrocytomas as compared to anaplastic astrocytomas and/or ..
  28. ncbi Effect of sesaminol glucosides on beta-amyloid-induced PC12 cell death through antioxidant mechanisms
    Sun Young Lee
    College of Pharmacy, Chungbuk National University, 48 Gaesin dong, Heungduk gu, Cheongju, Chungbuk 361 763, Republic of Korea
    Neurosci Res 52:330-41. 2005
    ..Sesaminol glucoside (50-250microg/ml) also effectively decreased Abeta1-42 and ADDL form of Abeta1-42 as well as the combination of H2O2 with FeSO4-induced cell damages...
  29. ncbi Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor
    Amanda J Haes
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    J Am Chem Soc 127:2264-71. 2005
    ..to monitor the interaction between the antigen, amyloid-beta derived diffusible ligands (ADDLs), and specific anti-ADDL antibodies...
  30. ncbi Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening
    Lei Chang
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    J Mol Neurosci 20:305-13. 2003
    ..In this work we describe the development of a dot-blot immunoassay to measure ADDL at the femtomole level, its use in defining the time course of ADDL formation, and its use in determining the ..
  31. pmc Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
    Dimitra G Georganopoulou
    Department of Chemistry and Institute of Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 102:2273-6. 2005
    ..b>ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from ..
  32. doi Transcriptional response of the bovine endometrium and embryo to endometrial polymorphonuclear neutrophil infiltration as an indicator of subclinical inflammation of the uterine environment
    Michael Hoelker
    Insititute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany
    Reprod Fertil Dev 24:778-93. 2012
    ..Of these, GZMK, TCEAL4, MYL7, ADD3 and THEM50B were upregulated, whereas NUDCD2, MYO1E, BZW1, EHD4 and GZMB were downregulated...
  33. doi The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis
    Dekker C Deacon
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Development 137:1887-96. 2010
    ..zebrafish that microRNA-143 (miR-143) is required for chamber morphogenesis through direct repression of adducin3 (add3), which encodes an F-actin capping protein...
  34. pmc Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal
    Jason Pitt
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Toxicol Appl Pharmacol 240:189-97. 2009
    ..of oligomers in the presence of OC showed an upward shift in MW and a ladder-like distribution of SDS-stable ADDL subspecies...
  35. doi A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells
    Cristina Cecchi
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
    Biochim Biophys Acta 1788:2204-16. 2009
    ..To shed further light on the relation between ADDL-cell membrane interaction and oligomer cytotoxicity, we investigated the dependence of ADDLs binding to lipid rafts ..
  36. doi Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    J Alzheimers Dis 18:787-98. 2009
    ..Furthermore, both constituents restored amyloid-beta oligomers (also known as ADDL)-induced synaptic loss and phosphorylation of CREB...
  37. pmc Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression
    Tarmo Annilo
    Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    BMC Mol Biol 10:81. 2009
    ..The goal of our study was to investigate the involvement of NATs in regulation of candidate genes for blood pressure...
  38. pmc Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption
    Wei Qin Zhao
    Department of Neurology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 285:7619-32. 2010
    ..acid (AMPA) receptor subunits and calcineurin as candidate genes potentially involved in ADDL-neuron interactions...
  39. pmc Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Neurodegener Dis 7:56-9. 2010
    ..It is believed that soluble amyloid-beta (Abeta) oligomers are involved in the pathogenesis of AD, yet the underlying mechanisms remain elusive...
  40. pmc Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites
    Darragh B Freir
    Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Republic of Ireland
    Nat Commun 2:336. 2011
    ..effects of ex vivo material from human AD brain and that standardized Aβ-derived diffusible ligand (ADDL) preparations disrupt hippocampal synaptic plasticity in a PrP-dependent manner...
  41. pmc Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis
    Domenico Bosco
    Department of Neuroscience, S Giovanni di Dio Hospital, Via Largo Bologna, Crotone, Italy
    J Cell Mol Med 15:1807-21. 2011
    ..Molecular mechanisms that protect CNS neurons against β-amyloid-derived-diffusible ligands (ADDL), responsible for synaptic deterioration underlying AD memory failure, have been identified...
  42. doi ADDLs and the signaling web that leads to Alzheimer's disease
    Grant A Krafft
    Acumen Pharmaceuticals, Glenview, IL 60025, USA
    Neuropharmacology 59:230-42. 2010
    ..the longstanding emphasis on fibrillar deposits and neuronal death has given way to a new paradigm involving ADDL-triggered aberrant synaptic signaling and consequent memory malfunction and neurodegeneration...
  43. doi Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers
    Anna Nogalska
    Department of Neurology, USC Neuromuscular Center, Good Samaritan Hospital, University of Southern California Keck School of Medicine, Los Angeles, CA 90017 1912, USA
    Acta Neuropathol 120:661-6. 2010
    ..None of the control muscle biopsies had Aβ oligomers. Dot-immunoblots using highly specific anti-ADDL monoclonal antibodies also showed highly increased ADDLs in all s-IBM biopsies studied, while controls were ..
  44. pmc Isolation and genetic analysis of bovine viral diarrhea virus from infected cattle in indiana
    Roman M Pogranichniy
    Indiana Animal Disease Diagnostic Laboratory and Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA
    Vet Med Int 2011:925910. 2011
    ..in 44 bovine viral diarrhea virus- (BVDV-) positive samples submitted to the Animal Disease Diagnostic Laboratory (ADDL) in Indiana during 2006-2008...
  45. pmc Polymorphic C-terminal beta-sheet interactions determine the formation of fibril or amyloid beta-derived diffusible ligand-like globulomer for the Alzheimer Abeta42 dodecamer
    Buyong Ma
    Basic Science Program, SAIC Frederick, Inc, Center for Cancer Research Nanobiology Program, National Cancer Institute, Frederick, Maryland 21702, USA
    J Biol Chem 285:37102-10. 2010
    ..One ADDL type, the "globulomer," apparently forms independently of the fibril aggregation pathway...
  46. doi Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies
    Chiara Lanzani
    Division of Nephrology and Dialysis, Chair of Nephrology, San Raffaele Scientific Institute, Universita Vita Salute San Raffaele Hospital, Milan 20132, Italy
    Sci Transl Med 2:59ra87. 2010
    ..MDR1/ABCB1 [ATP-binding cassette, sub-family B (MDR/TAP), member 1]}, and adducin activity [ADD1 (adducin 1) and ADD3], and the responses to antihypertensive medications...
  47. pmc γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter
    Henrik Dimke
    Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Am Soc Nephrol 22:508-17. 2011
    ..These data suggest that γ-adducin may influence BP homeostasis by modulating renal NaCl transport...
  48. doi Curcuminoid binds to amyloid-β1-42 oligomer and fibril
    Daijiro Yanagisawa
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa cho, Otsu, Japan
    J Alzheimers Dis 24:33-42. 2011
    ..any interaction between curcumin and Aβ oligomers such as globulomer and Aβ-derived diffusible ligand (ADDL)...
  49. ncbi NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15)
    Idoya Lahortiga
    Department of Genetics, University of Navarra, 31008 Pamplona, Spain
    Cancer Res 63:3079-83. 2003
    ..The gene involved, located in 10q25, was identified as ADD3 using 3'-RACE...
  50. pmc Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ
    Kristina B Kruse
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Mol Biol Cell 17:203-12. 2006
    ..The defect in one of these mutants, add3, was complemented by VPS30/ATG6, a gene that encodes a component of two phosphatidylinositol 3-kinase (PtdIns 3-..
  51. ncbi Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2
    Mustafa N Yenerel
    Puget Sound Blood Center, University of Washington, Seattle, 98104, USA
    Exp Hematol 33:758-66. 2005
    The first objective of this study was to examine the differences in levels of adducin (ADD1, ADD2, ADD3) mRNA expression during human erythropoiesis...
  52. ncbi Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans
    Marcin Cwynar
    Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Cracow, Poland
    J Hypertens 23:961-9. 2005
    ....
  53. ncbi Role of the adducin family genes in human essential hypertension
    Chiara Lanzani
    Division of Nephrology, Dialysis and Hypertension University Vita Salute, IRCCS San Raffaele Hospital, Milano, Italy
    J Hypertens 23:543-9. 2005
    ..Adducin functions within cells as a heterodimer composed of various combinations of three subunits that are coded by three genes (ADD1, 2, 3) each located on a different chromosome...
  54. ncbi Adducin polymorphism: detection and impact on hypertension and related disorders
    Giuseppe Bianchi
    School of Nephrology, Dialysis and Hypertension, University Vita Salute San Raffaele, Milan, Italy
    Hypertension 45:331-40. 2005
    Adducin is a heterodymeric cytoskeleton protein, the 3 subunits of which are encoded by genes (ADD1, ADD2, ADD3) mapping to 3 different chromosomes...
  55. ncbi Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum
    Peter J Margetts
    Department of Medicine, McMaster University, Division of Nephrology, Street Joseph s Hospital, 50 Charl ton Avenue E, Hamilton, Ontario, Canada, L8P 4A6
    J Am Soc Nephrol 16:425-36. 2005
    ..injection of an adenovirus vector that transfers active TGF-beta1 (AdTGF-beta1) or control adenovirus, AdDL. Animals were killed 0 to 21 days after infection. Peritoneal effluent and tissue were analyzed for markers of EMT...
  56. ncbi Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates
    Christian B Gocke
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 280:5004-12. 2005
    ..Therefore, sumoylation appears to regulate the functions of its substrates through multiple, context-dependent mechanisms...
  57. ncbi Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats
    Grazia Tripodi
    Prassis sigma tau Research Institute, Settimo Milanese, Milan, Italy
    Biochem Biophys Res Commun 324:562-8. 2004
    Genetic variants of alpha adducin (ADD1) taken alone or in interaction with those of beta (ADD2) and gamma (ADD3) subunits have been associated with primary hypertension in humans and in Milan hypertensive (MHS) rats...
  58. ncbi Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants
    Lorena Citterio
    Division of Nephrology, Dialysis and Hypertension, Universita Vita Salute, San Raffaele Hospital, Milan, Italy
    Biochem Biophys Res Commun 309:359-67. 2003
    Adducin is a cytoskeleton heterodimeric protein. Its subunits are encoded by three related genes (ADD1, ADD2, and ADD3) which show alternative spliced variants...
  59. ncbi NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique
    S P Romana
    Service de Cytogénétique, Centre Hospitalier Universitaire CHU Necker Enfants Malades, Paris, France
    Leukemia 20:696-706. 2006
    ..Involvement of ADD3 and C6ORF80 genes were detected, respectively, in myeloid disorders and in T-cell acute lymphoblastic leukemia (T-..
  60. ncbi Detection of bovine torovirus and other enteric pathogens in feces from diarrhea cases in cattle
    Armando E Hoet
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
    J Vet Diagn Invest 15:205-12. 2003
    ..BoTV) in bovine fecal samples from diarrhea cases submitted to the Ohio Animal Disease Diagnostic Laboratory (ADDL) and to assess if a relationship exists between BoTV and the other enteric pathogens detected...
  61. ncbi Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Hepatol 37:788-96. 2002
    ..TSA retained a more quiescent phenotype in spite of culture conditions that favor transdifferentiation into activated HSC...
  62. ncbi Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets
    William L Klein
    Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Institute for Neuroscience, 2153 North Campus Drive, 60208, Evanston, IL, USA
    Neurochem Int 41:345-52. 2002
    ..The presence of high affinity ADDL binding proteins in hippocampus and frontal cortex but not cerebellum parallels the regional specificity of AD ..
  63. ncbi Adducin in platelets: activation-induced phosphorylation by PKC and proteolysis by calpain
    Diana M Gilligan
    Department of Internal Medicine Hematology, Yale University School of Medicine, New Haven, CT, USA
    Blood 99:2418-26. 2002
    ..Our results suggest that regulation of adducin function by PKC and calpain may play a role in platelet aggregation...
  64. ncbi Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats
    L Zagato
    Division of Nephrology, Dialysis and Hypertension, S Raffaele Hospital, Milan, Italy
    Hypertension 36:734-9. 2000
    ..normotensive strain) F2 rats to further investigate the contribution of the adducin gene family (Add1, Add2, and Add3) and to identify novel quantitative trait loci (QTLs) that affect blood pressure...
  65. ncbi Genomic organization of the human gamma adducin gene
    L Citterio
    Division of Nephrology, Dialysis and Hypertension, San Raffaele Hospital, Milan, Italy
    Biochem Biophys Res Commun 266:110-4. 1999
    We report the genomic structure of the human gamma adducin gene (ADD3). Adducin is a protein involved in cytoskeletal assembly and composed of alpha-beta or alpha-gamma subunits which share a high degree of homology between human and rat...
  66. pmc Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice
    D M Gilligan
    Department of Internal Medicine Hematology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 96:10717-22. 1999
    ..This study demonstrates adducin's importance to RBC membrane stability in vivo...
  67. ncbi Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin
    T Katagiri
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan
    Cytogenet Cell Genet 74:90-5. 1996
    From a human fetal-brain cDNA library we isolated a novel human cDNA, termed human adducin-like 70 (gene symbol ADDL), whose predicted amino acid sequence showed a high degree of homology to adducins...
  68. ncbi Why Alzheimer's is a disease of memory: the attack on synapses by A beta oligomers (ADDLs)
    K L Viola
    Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer s Disease Center, Northwestern University, Evanston, IL 60208, USA
    J Nutr Health Aging 12:51S-7S. 2008
    ..reported to occur in tgmouse AD models where they emerge concomitantly with memory failure (4), consistent with ADDL inhibition of LTP (1)...
  69. pmc Targeted deletion of the gamma-adducin gene (Add3) in mice reveals differences in alpha-adducin interactions in erythroid and nonerythroid cells
    Kenneth E Sahr
    The Jackson Laboratory, Bar Harbor, Maine 04606, USA
    Am J Hematol 84:354-61. 2009
    ..These results suggest that the structural properties of adducin differ significantly between erythroid and various nonerythroid cell types...
  70. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
    ..insulin resistance syndrome, or inhibition of insulin and IGF-1 receptors via pharmacological reagents increases ADDL levels by exacerbating their aggregation...
  71. doi Local veterinary diagnostic laboratory, a model for the one health initiative
    Gundula Dunne
    County of San Diego, Department of Agriculture, Weights, and Measures, Office of the County Veterinarian, Animal Disease Diagnostic Laboratory, 5555 Overland Avenue, Suite 4103, San Diego, CA 92123, USA
    Vet Clin North Am Small Anim Pract 39:373-84. 2009
    The San Diego County Animal Disease Diagnostic Laboratory (ADDL) is unique in its emphasis on protecting both human and animal health in San Diego County, and its use of interagency and community collaboration to create strong, effective ..
  72. doi Arterial properties in relation to genetic variations in the adducin subunits in a white population
    Jitka Seidlerova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Am J Hypertens 22:21-6. 2009
    ..We investigated whether arterial characteristics might be related to the genes encoding ADD1 (Gly460Trp-rs4961), ADD2 (C1797T-rs4984), and ADD3 (IVS11+386A>G-rs3731566).
  73. doi Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Ménière's syndrome
    Roberto Teggi
    ENT Department, San Raffaele Scientific Institute, Vita Salute University San Raffaele, Milan, Italy
    Otol Neurotol 29:824-8. 2008
    ..cytoskeleton protein consisting of 3 subunits (alpha, beta, and gamma) coded by 3 different genes (ADD1, ADD2, and ADD3)...
  74. ncbi Identification of potential chemoresistance genes in osteosarcoma
    Denise Katherine Walters
    Laboratory for Orthopaedic Research, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland
    Anticancer Res 28:673-9. 2008
    ..The poor survival rate of these patients is largely due to their lack of responsiveness to chemotherapy. However, the mechanisms underlying osteosarcoma chemoresistance remain unknown...
  75. doi Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons
    P J Shughrue
    Department of Alzheimer s Research, Merck Research Laboratories, West Point, PA 19486, USA paul
    Neurobiol Aging 31:189-202. 2010
    ..To further investigate ADDL binding to neurons and identify antibodies that block this association, a panel of anti-Abeta and anti-ADDL ..
  76. doi Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 26:1229-36. 2008
    We investigated the possible association between left ventricular diastolic function and the ADD1 Gly460Trp and ADD3 IVS11 +386A>G polymorphisms alone and in combination.
  77. ncbi Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease
    Gary C Look
    Acumen Pharmaceuticals, Inc 385 Oyster Point Blvd, Suite 9A, South San Francisco, CA 94080, USA
    Curr Alzheimer Res 4:562-7. 2007
    ..We have developed a screening cascade which identifies small molecule modulators of ADDL-mediated neurotoxicity...
  78. pmc Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:9090-103. 2009
    ..More importantly, ADDL-induced synaptic change (i.e...
  79. ncbi Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism
    Ritchie Williamson
    MRC Centre for Neurodegeneration Research, Department of Neuroscience Box 037, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    FASEB J 22:1552-9. 2008
    ..b>ADDL-induced dynamic alterations in lipid raft protein composition were found to facilitate this movement...
  80. ncbi Adducin polymorphisms and the treatment of hypertension
    Paolo Manunta
    Universita Vita Salute San Raffaele Hospital, Division of Nephrology, Dialysis and Hypertension, Scientific Institute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Pharmacogenomics 8:465-72. 2007
    ..Adducin is a heterodimeric cytoskeleton protein, the three subunits of which are encoded by genes (ADD1, ADD2 and ADD3) that map to three different chromosomes...
  81. pmc Adenoviral gene transfer of bioactive TGFbeta1 to the rodent eye as a novel model for anterior subcapsular cataract
    Jennifer V Robertson
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, ON, Canada
    Mol Vis 13:457-69. 2007
    ..Establishment of this model will be important for further investigations of TGFbeta-induced signaling cascades in ASC...
  82. ncbi Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 282:11590-601. 2007
    ..b>ADDL binding to neurons was reduced and ROS formation was completely blocked by an antibody to the extracellular domain ..
  83. ncbi Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12)
    Ioannis Panagopoulos
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Br J Haematol 136:294-6. 2007
    Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. We report a T-ALL with t(11;18)(p15;q12) resulting in a novel NUP98 fusion...
  84. ncbi Solution state characterization of amyloid beta-derived diffusible ligands
    Robert W Hepler
    Department of Vaccine and Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Biochemistry 45:15157-67. 2006
    ..Accurate biophysical characterization of ADDL preparations is hampered by the peptide's strong tendency to self-associate and the effect of factors such as ionic ..
  85. ncbi Monoclonal antibodies that target pathological assemblies of Abeta
    Mary P Lambert
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurochem 100:23-35. 2007
    ..b>ADDL-induced reactive oxygen species (ROS) generation was also inhibited, establishing this response to be oligomer-..
  86. ncbi Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm
    Paolo Manunta
    Division of Nephrology, Dialysis, and Hypertension, University Vita Salute San Raffale, Via Olgettina 60, 20131 Milan, Italy
    J Am Soc Nephrol 17:S30-5. 2006
    ..Adducin is a heterodimeric cytoskeleton protein, the three subunits of which are encoded by genes (ADD1, ADD2, and ADD3) that map to three different chromosomes...

Research Grants20

  1. Targeting Amyloid Intermediates by Design and Selection
    Indraneel Ghosh; Fiscal Year: 2006
    ..that the toxicity of Ab may lie in the soluble oligomeric intermediates also called Ab-derived diffusible ligands (ADDL)...
  2. A High-Pressure Freezing and Cryoprocessing System for Northwestern University
    WILLIAM RUSSIN; Fiscal Year: 2007
    ..5) the role of BRCA2 and centrobin in the regulation of centrosome duplication in cultured tumor cells, and 6) ADDL-induced synaptic spine changes in primary hippocampal cultures...
  3. Abeta oligomers (ADDLs) in Alzheimer's Disease pathology
    William L Klein; Fiscal Year: 2010
    ..that ADDLs in CSF/plasma provide a reliable AD biomarker;(ii) Verify that the earliest preclinical sign of AD is ADDL accumulation around individual neurons;(iii) Test the prediction that neurons surrounded by ADDLs develop AD ..
  4. Mitochondrial Fission and Fusion in Alzheimer Disease
    Xiongwei Zhu; Fiscal Year: 2012
    ..abnormalities via its toxic effect on mitochondrial fission/fusion in vitro;Aim2) To Explore the Mechanisms of ADDL-induced DLP1 Reduction;Aim3) mutant PS1 causes mitochondrial abnormalities and neuronal dysfunction at least in ..
  5. Soluble Membrane Protein Libraries: Design and use in Alzheimers drug discovery
    KYLE CHRISTOPHER WILCOX; Fiscal Year: 2012
    ..Previous work in the Klein lab and other labs suggests that ADDL targeting is specific and receptor-mediated - binding synaptic sites in a tissue-, cell-, and synapse-specific ..
  6. DAVID RAE HARDER; Fiscal Year: 2015
    ..2 M base pair quantitative trait loci (QTL) containing the gene for adducin3 (Add3) and DUSP-5 along with other incomplete genes. Transfer of this 1...
  7. Defense against Alzheimer??s-associated A?? oligomers by CNS insulin signaling
    JASON ERNEST PITT; Fiscal Year: 2011
    ..Insulin signaling has been identified by our lab as an anti-ADDL protective pathway, preventing ADDL binding and toxicity to hippocampal neurons...
  8. Impaired Myogenic Response and Risk of Renal and Vascular Disease with Aging
    Marilyn Burke; Fiscal Year: 2012
    ..The 3rd aim is to evaluate the ability of sequence variants in Add3 and Dusp5 and any other positional candidate genes to alter myogenic tone in the renal and cerebral vasculature of ..
  9. Evaluation of Salmonella Symptomatic and Asymptomatic Pets: Study for Vet-LRN Pro
    Jing Cui; Fiscal Year: 2012
    ..The purpose of this proposal from ODA's Animal Disease Diagnostic Laboratory (ADDL)'s Bacteriology Section is to study the prevalence of Salmonella in fecal samples from both symptomatic and ..
  10. Mechanism of Amyloid Beta-Aggregation
    MICHAEL GERARD ZAGORSKI; Fiscal Year: 2010
    ..Detailed information of the intermolecular organization within the ADDL assembly remains unknown...
  11. Yan Zhang; Fiscal Year: 2016
    ..The purpose of this proposal from ODA's Animal Disease Diagnostic Laboratory (ADDL) is to address the following three key project areas: 1...
  12. Stephen B Hooser; Fiscal Year: 2016
    Non-Technical Summary: Through this cooperative agreement, the Indiana ADDL at Purdue University with its diagnostic personnel and testing capabilities, will work with the FDA CVM Vet-LRN to meet its goal to complement, develop, and ..
  13. Arrested Development of Arabidopsis
    F Pickett; Fiscal Year: 2003
    ..The add3 mutation causes a temperature dependent loss of cell proliferation in the marginal regions of leaves, suggesting ..
  14. NEUROLOGICAL DEFICITS DUE TO TOXIC A BETA OLIGOMERS
    WILLIAM KLEIN; Fiscal Year: 2003
    ..The goal is to understand the molecular basis for ADDL neurotoxicity. Two hypotheses will be evaluated...
  15. ADDLs, synapses & the molecular etiology of Alzheimer's disease
    WILLIAM KLEIN; Fiscal Year: 2009
    ..Our hypothesis is that ADDL attachment to synapses is the mechanistic starting point common to all AD neuronal pathology...
  16. DETECTION OF ALZHEIMER'S DISEASE USING A POLYMER NANOWIRE-BASED BIOSENSOR
    MAKSUDUL ALAM; Fiscal Year: 2009
    ..been proposed to establish the Phase I feasibility of detecting amyloid-[unreadable] derived diffusible ligand (ADDL) antigen, a biomarker for AD, using amyloid-[unreadable] (A[unreadable]) oligomer specific antibody to ADDLs...
  17. Abnormal Megakaryocyte Development
    DIANA GILLIGAN; Fiscal Year: 2006
    ..Finally, these studies may help in the targeted development of better platelet lowering drugs using rational design to improve on currently available options such as anagrelide, hydroxyurea, and interferon. ..
  18. Drug discovery of anti-ADDL therapeutics for Alzheimer's
    GRANT KRAFFT; Fiscal Year: 2005
    ..In Tg2576 AD mice, a transgenic Alzheimer's disease animal model, memory performance declines as ADDL levels increase...
  19. Biomarker for Alzheimer's Related Cognitive Deficits
    GRANT KRAFFT; Fiscal Year: 2005
    ..Elevated ADDL levels correlate with synaptic dysfunction, and the appearance of ADDLs in brain tissue coincides with cognitive ..
  20. ADDUCIN ISOFORMS IN RBC AND PLATELET DIFFERENTIATION
    DIANA GILLIGAN; Fiscal Year: 2003
    ..abstract_text> ..