adiponectin

Summary

Gene Symbol: adiponectin
Description: adiponectin, C1Q and collagen domain containing
Alias: ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, adipose specific collagen-like factor, gelatin-binding protein 28
Species: human

Top Publications

  1. pmc A genome-wide association study reveals variants in ARL15 that influence adiponectin levels
    J Brent Richards
    Departments of Medicine, Human Genetics, and Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    PLoS Genet 5:e1000768. 2009
  2. ncbi Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    T Yokota
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Blood 96:1723-32. 2000
  3. ncbi The role of the novel adipocyte-derived hormone adiponectin in human disease
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Endocrinol 148:293-300. 2003
  4. ncbi Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 8:1288-95. 2002
  5. pmc Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals
    Iris M Heid
    Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany
    Atherosclerosis 208:412-20. 2010
  6. pmc Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
    Ebba Brakenhielm
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:2476-81. 2004
  7. ncbi Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
    Anna M Wolf
    Department of Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Biochem Biophys Res Commun 323:630-5. 2004
  8. pmc Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ
    Ying Wu
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Hum Mol Genet 19:4955-64. 2010
  9. ncbi A novel serum protein similar to C1q, produced exclusively in adipocytes
    P E Scherer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 270:26746-9. 1995
  10. ncbi Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Am J Physiol Endocrinol Metab 285:E527-33. 2003

Research Grants

  1. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
  2. Metabolic Characterization of the Novel Adipokine CTRP3
    Jonathan Peterson; Fiscal Year: 2011
  3. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
  4. Depression, Adipocytokines and Metabolic Dysregulation in Black and White Women
    Susan A Everson Rose; Fiscal Year: 2010
  5. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2012
  6. Andrew B Muir; Fiscal Year: 2014
  7. NICOLE LENORE MIHALOPOULOS; Fiscal Year: 2014
  8. Lei Cao; Fiscal Year: 2014
  9. Timothy E McGraw; Fiscal Year: 2016
  10. Childhood Precursors for Adulthood Metabolic Syndrome
    Shumei S Sun; Fiscal Year: 2010

Patents

  1. Use of OBG3 for promoting central nervous system remyelination

Detail Information

Publications436 found, 100 shown here

  1. pmc A genome-wide association study reveals variants in ARL15 that influence adiponectin levels
    J Brent Richards
    Departments of Medicine, Human Genetics, and Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    PLoS Genet 5:e1000768. 2009
    The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD)...
  2. ncbi Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    T Yokota
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Blood 96:1723-32. 2000
    We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses...
  3. ncbi The role of the novel adipocyte-derived hormone adiponectin in human disease
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Endocrinol 148:293-300. 2003
    b>Adiponectin, also called GBP-28, apM1, AdipoQ and Acrp30, is a novel adipose tIssue-specific protein that has structural homology to collagen VIII and X and complement factor C1q, and that circulates in human plasma at high levels...
  4. ncbi Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 8:1288-95. 2002
    b>Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects of Ad remain poorly identified...
  5. pmc Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals
    Iris M Heid
    Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany
    Atherosclerosis 208:412-20. 2010
    Plasma adiponectin is strongly associated with various components of metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are highly heritable and differ between men and women...
  6. pmc Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
    Ebba Brakenhielm
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:2476-81. 2004
    ..The adipose tissue produces several growth factors/hormones including leptin, tumor necrosis factor alpha, and adiponectin. It has been found that adiponectin levels are reduced in obesity...
  7. ncbi Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
    Anna M Wolf
    Department of Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Biochem Biophys Res Commun 323:630-5. 2004
    ..The most abundant protein within the adipocyte is adiponectin. Our current work reports that adiponectin has potent immuno-suppressive properties, as it induces the ..
  8. pmc Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ
    Ying Wu
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Hum Mol Genet 19:4955-64. 2010
    b>Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism...
  9. ncbi A novel serum protein similar to C1q, produced exclusively in adipocytes
    P E Scherer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 270:26746-9. 1995
    We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation...
  10. ncbi Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Am J Physiol Endocrinol Metab 285:E527-33. 2003
    b>Adiponectin is an adipose tissue-specific protein that is abundantly present in the circulation and suggested to be involved in insulin sensitivity and development of atherosclerosis...
  11. ncbi Adiponectin and future coronary heart disease events among men with type 2 diabetes
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 54:534-9. 2005
    b>Adiponectin, predominantly synthesized in the adipose tissue, seems to have substantial anti-inflammatory properties and to be a major modulator of insulin resistance and dyslipidemia, mechanisms that are associated with an increased ..
  12. ncbi Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 100:2473-6. 1999
    Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity...
  13. ncbi Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women
    Miyao Matsubara
    Division of Endocrinology and Metabolism, Otaru City General Hospital, Otaru, Japan
    Eur J Endocrinol 147:173-80. 2002
    b>Adiponectin, a novel adipocyte-derived collagen-like protein, is the gene product of the adipose most-abundant gene transcript 1 (apM1), which has been considered to have anti-inflammatory and anti-atherogenic effects.
  14. ncbi Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
    Masanori Iwaki
    Department of Medicine and Pathophysiology, Graduate School of Frontier Biosciences, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 52:1655-63. 2003
    b>Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties. Hypoadiponectinemia seen in obesity is associated with insulin-resistant diabetes and atherosclerosis...
  15. ncbi Adiponectin and metabolic syndrome
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School, Sumitomo Hospital, Osaka, Japan
    Arterioscler Thromb Vasc Biol 24:29-33. 2004
    ..sequence analysis of expressed genes in adipocytes, we identified an adipose-specific collagen-like molecule, adiponectin. This novel adipocytokine has plural biofunctions, such as antidiabetic, antiatherosclerotic, and ..
  16. doi Effects of exercise on adiponectin: a systematic review
    Kylie A Simpson
    School of Exercise and Sport Science, University of Sydney, Sydney, NSW, Australia
    Obesity (Silver Spring) 16:241-56. 2008
    Secreted from white adipose tissue, circulating concentrations of adiponectin are reduced in the presence of metabolic and cardiovascular disease such as obesity and type 2 diabetes...
  17. doi Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis
    M Gong
    Department of Endocrinology, The First Affiliated Hospital, Chongqing Medical University, Yuzhong District No 1 Youyi Road, YuanJiaGang, Chongqing 400016, PR China
    Mol Cell Endocrinol 325:78-83. 2010
    ..046, OR=1.09, 95% CI 1.00-1.09). In conclusion, the accumulated evidence suggested that the ADIPOQ -11377G allele is a low-penetrant risk factor for developing type 2 diabetes, but -11391A is a risk factor only in European Caucasians...
  18. ncbi Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease
    Claudia Menzaghi
    Research Unit of Diabetology and Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Diabetes 56:1198-209. 2007
    ..Among these molecules, adiponectin has drawn much attention because of its insulin-sensitizing and antiatherogenic actions, suggesting that ..
  19. pmc Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity
    Antonino Tuttolomondo
    Dipartimento Biomedico di Medicina Interna e Specialistica Università degli Studi di Palermo, Italy
    Cardiovasc Diabetol 9:50. 2010
    ..On this basis the aim of our study was to evaluate plasma levels of adiponectin, resistin and IL-6 in subjects with diabetic foot in comparison with subjects without foot complications.
  20. ncbi AdipoQ is a novel adipose-specific gene dysregulated in obesity
    E Hu
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 271:10697-703. 1996
    ..Whereas the biological function of this polypeptide is presently unknown, the tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue...
  21. ncbi Hypoadiponectinemia is an independent risk factor for hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 43:1318-23. 2004
    b>Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease...
  22. ncbi Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study
    Bjoern Becker
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 16:1091-8. 2005
    The relationship among insulin resistance, adiponectin, and cardiovascular (CV) morbidity in patients with mild and moderate kidney disease was investigated...
  23. ncbi Associations between two single nucleotide polymorphisms of adiponectin gene and coronary artery diseases
    Chan Hee Jung
    Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Endocr J 53:671-7. 2006
    b>Adiponectin, an adipocyte-secreted protein, is known to have anti-atherogenic, anti-inflammatory and anti-diabetic properties and its serum levels are decreased in obesity, type 2 diabetes, and coronary artery disease...
  24. ncbi Genomic structure and mutations in adipose-specific gene, adiponectin
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Obes Relat Metab Disord 24:861-8. 2000
    b>Adiponectin is a collagen-like plasma protein specifically synthesized in adipose tissue. Plasma adiponectin concentrations are decreased in obesity whereas it is adipose-specific.
  25. ncbi Decreased plasma adiponectin concentration in patients with essential hypertension
    Marcin Adamczak
    Department of Nephrology, Endocrinology and Metabolic Diseases, Silesian University School of Medicine, Katowice, Poland
    Am J Hypertens 16:72-5. 2003
    ..There are no reports that deal with the relationship between plasma adiponectin concentration and blood pressure (BP)...
  26. doi Adiponectin affects lung epithelial A549 cell viability counteracting TNFα and IL-1ß toxicity through AdipoR1
    Ersilia Nigro
    CEINGE Biotecnologie Avanzate scarl, Naples, Italy
    Int J Biochem Cell Biol 45:1145-53. 2013
    b>Adiponectin (Acrp30) exerts protective functions on metabolic and cellular processes as energy metabolism, cell proliferation and differentiation by two widely expressed receptors, AdipoR1 and AdipoR2...
  27. doi Adiponectin protects endothelial cells from the damages induced by the intermittent high level of glucose
    Xinhua Xiao
    Department of Metabolism and Endocrinology, The First Affiliated Hospital, University of South China, 69 Chuanshan Road, Hengyang, 421001, People s Republic of China
    Endocrine 40:386-93. 2011
    Globular adiponectin (gAd) has anti-atherogenic effects on the vascular wall. Intermittent hyperglycemia induces endothelial cells (ECs) injury but the physiological factors that may protect against ECs damage are largely unknown...
  28. pmc Prospective study of serum adiponectin and incident metabolic syndrome: the ARIRANG study
    Jang Young Kim
    Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea
    Diabetes Care 36:1547-53. 2013
    Increased adiponectin levels may play a protective role in the development of metabolic abnormalities, but prospective studies of the predictive value of serum adiponectin to identify individuals at high risk of new-onset metabolic ..
  29. pmc Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1304-9. 2004
    b>Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro and in vivo...
  30. doi High adiponectin and increased risk of cardiovascular disease and mortality in asymptomatic older men: does NT-proBNP help to explain this association?
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Health, UCL, London, UK
    Eur J Cardiovasc Prev Rehabil 18:65-71. 2011
    Raised adiponectin is associated with increased rather than decreased risk of cardiovascular disease (CVD) and mortality at older age...
  31. pmc Total and high-molecular-weight adiponectin and risk of coronary heart disease and ischemic stroke in older adults
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Clin Endocrinol Metab 98:255-63. 2013
    b>Adiponectin is atheroprotective in the laboratory, but prospective studies have shown opposite associations with cardiovascular disease (CVD) in healthy middle-aged populations (protective) and older cohorts (adverse)...
  32. pmc Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity
    Koon Ho Chan
    University Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Special Administrative Region, China
    PLoS ONE 7:e52354. 2012
    ..We studied the potential protective effect of adiponectin (an adipokine with insulin-sensitizing, anti-inflammatory and anti-oxidant properties) against Aβ ..
  33. doi Adiponectin and resistin gene polymorphisms in association with their respective adipokine levels
    Cia Hin Lau
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Ann Hum Genet 75:370-82. 2011
    Single nucleotide polymorphisms (SNPs) at the adiponectin and resistin loci are strongly associated with hypoadiponectinemia and hyperresistinemia, which may eventually increase risk of insulin resistance, type 2 diabetes (T2DM), ..
  34. pmc Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4
    Min Ding
    Section of Vascular Surgery, Department of Surgery, Dartmouth Medical School, Lebanon, NH, USA
    Arterioscler Thromb Vasc Biol 31:1403-10. 2011
    The adipocyte-secreted hormone adiponectin exerts important cardioprotective and antidiabetic effects. Little is known about its effect on vascular smooth muscle cells (VSMC), key cells in restenosis, hypertension, and atherosclerosis.
  35. ncbi Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects
    D R Gable
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, 5 University Street, London WC1E 6JF, UK
    Ann Hum Genet 71:453-66. 2007
    ..These conditions have been associated with variation in the adiponectin gene, although evidence for this relationship has been variable, with differences found even in similar samples...
  36. pmc Fetuin-A induces cytokine expression and suppresses adiponectin production
    Anita M Hennige
    Department of Internal Medicine, Division of Endocrinology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    PLoS ONE 3:e1765. 2008
    ..therefore, hypothesized that fetuin-A may play a role in the regulation of cytokine expression, the modulation of adipose tissue expression and plasma concentration of the insulin-sensitizing and atheroprotective adipokine adiponectin.
  37. doi Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population
    Fang Liu
    Department of Neurology, The First Affiliated Hospital of China Medical University, No 155 Nangjing North Street, Shenyang, 110001 Liaoning Province, People s Republic of China
    Mol Biol Rep 38:1983-8. 2011
    b>Adiponectin is inversely associated with the risk of ischemic stroke through its anti-inflammatory and anti-atherogenic effects...
  38. pmc Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents
    Sheela N Magge
    Division of Endocrinology and Diabetes, The Children s Hospital of Philadelphia, 3535 Market Street, 15th Floor Suite 1578, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 96:1549-54. 2011
    Children with obesity and insulin resistance (IR) have decreased adiponectin and have increased cardiovascular risk. Adiponectin has antiatherogenic effects, but its mechanism is unclear.
  39. pmc Clinical review: adiponectin biology and its role in inflammation and critical illness
    Katherine Robinson
    Intensive Care Unit, Wesley Hospital, Auchenflower, Brisbane, Queensland, Australia
    Crit Care 15:221. 2011
    b>Adiponectin is an adipokine first described just over a decade ago. Produced almost exclusively by adipocytes, adiponectin circulates in high concentrations in human plasma...
  40. doi Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity
    Sittisak Honsawek
    Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand
    Arch Med Res 41:593-8. 2010
    ..The purposes of this study were to measure adiponectin concentrations in plasma and synovial fluid of patients with knee OA and to analyze the correlation of ..
  41. pmc Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 19:4112-20. 2010
    ..This approach has been used to identify a rare (1.1%) G45R mutation in the gene encoding adiponectin, ADIPOQ. This variant explains a strong linkage signal (LOD > 8...
  42. doi The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity
    T Mracek
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Clin Endocrinol (Oxf) 72:334-41. 2010
    ..The study also examined the association between ZAG and adiponectin expression in human adipose tissue, and whether ZAG modulates adiponectin secretion by human adipocytes.
  43. ncbi Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 102:1296-301. 2000
    Among the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity...
  44. ncbi Hypoadiponectinemia is closely linked to endothelial dysfunction in man
    Michio Shimabukuro
    Second Department of Internal Medicine, University of the Ryukyus, 903 0215 Okinawa, Japan
    J Clin Endocrinol Metab 88:3236-40. 2003
    ..We asked what the relationship was between adiponectin, an adipose-specific molecule, and endothelial function...
  45. ncbi Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly
    Wei Shiung Yang
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Am J Clin Nutr 86:509-13. 2007
    Genetic variations of the human adiponectin gene are associated with metabolic phenotypes, including obesity, insulin sensitivity, and diabetes. However, these associations have not been examined in an elderly population.
  46. pmc Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells
    Xiang Cheng
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 287:36896-904. 2012
    Abundant experimental and clinical data support a modulatory role for adiponectin in inflammation, dysmetabolism, and disease...
  47. doi Globular adiponectin inhibits angiotensin II-induced nuclear factor kappaB activation through AMP-activated protein kinase in cardiac hypertrophy
    Cheng Wang
    Key Laboratory of Molecular Cardiovascular Sciences, Department of Physiology and Pathophysiology, Peking University Health Science Center, Ministry of Education, Beijing, China
    J Cell Physiol 222:149-55. 2010
    ..b>Adiponectin, an adipocyte-derived polypeptide, suppresses cardiac hypertrophy in response to pressure overload...
  48. ncbi Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population
    Yukihiro Yamamoto
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 89:87-90. 2004
    It has been reported that the serum adiponectin level was negatively correlated with body mass index (BMI), insulin resistance index, and triglycerides and was positively correlated with high-density lipoprotein cholesterol in several ..
  49. ncbi Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction
    Antonios M Xydakis
    Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 89:2697-703. 2004
    ..b>Adiponectin has been implicated in both the pathogenesis of obesity-related insulin resistance and increased inflammation...
  50. ncbi Plasma adiponectin and gastric cancer
    Makoto Ishikawa
    Department of Surgery, Division of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Cancer Res 11:466-72. 2005
    ..b>Adiponectin is a peptide hormone secreted by adipose tissue, affecting the proliferation and insulin sensitivity of various ..
  51. pmc Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II
    Ming Hsi Wang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Prostate 69:874-85. 2009
    ..Chronic intra-prostatic inflammation and obesity are thought to influence prostate carcinogenesis. Thus, variants in genes in these pathways could be associated with prostate cancer risk...
  52. ncbi Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects
    May Faraj
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 88:1594-602. 2003
    We examined fasting plasma insulin, acylation-stimulating protein (ASP), leptin, adiponectin, ghrelin, and metabolic/cardiovascular risk profile before and 15 +/- 6 months after isolated Roux-en-Y gastric bypass surgery in 50 morbidly ..
  53. doi Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages
    Kazumi Tsubakio-Yamamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamamdaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 375:390-4. 2008
    ..b>Adiponectin (APN) secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis...
  54. pmc Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data
    Helmut Laumen
    Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Munich, Germany
    Diabetes 58:984-91. 2009
    b>Adiponectin (APM1, ACDC) is an adipocyte-derived protein with downregulated expression in obesity and insulin-resistant states...
  55. doi A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India
    Vipin Gupta
    South Asia Network for Chronic Disease, Public Health Foundation of India, Delhi 110016
    Ann Hum Genet 74:361-8. 2010
    ..In spite of a culturally-learned sedentary lifestyle and fat-enriched dietary habits, WHR rather than body-mass-index emerged as a robust predictor of risk for T2D in this population...
  56. ncbi Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity
    Utpal B Pajvani
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 278:9073-85. 2003
    Acrp30/adiponectin is an adipocyte-specific secretory protein that has recently been implicated as a mediator of systemic insulin sensitivity with liver and muscle as target organs...
  57. ncbi Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians
    Barbora Vozarova de Courten
    Translational Genomics Research Institute, Diabetes Research Unit, NIDDK, NIH, 400 North 5th St, Phoenix, Arizona, USA
    Diabetes 54:284-9. 2005
    b>Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes...
  58. pmc Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk
    Virginia G Kaklamani
    Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cancer Res 68:3178-84. 2008
    Breast cancer risk is higher among obese women and women with diabetes. Adiponectin is a protein exclusively secreted by adipose tissue, circulating levels of which have been associated with breast cancer risk...
  59. ncbi Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
    Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance...
  60. ncbi Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study
    Frederic Fumeron
    EA 3516, Interactions Gènes Environnement dans les Pathologies Métaboliques à Risque Cardiovasculaire, Faculte Xavier Bichat, Paris, France
    Diabetes 53:1150-7. 2004
    The plasma concentration of the adipocyte-derived peptide adiponectin is decreased in patients with obesity and type 2 diabetes. The adiponectin gene is located on chromosome 3q27, where a diabetes susceptibility locus has been mapped...
  61. ncbi Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 85:26-34. 2007
    Despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adiposity-related phenotypes.
  62. ncbi Circulating and cellular adiponectin in polycystic ovary syndrome: relationship to glucose tolerance and insulin action
    Vanita Aroda
    VA San Diego Healthcare System, San Diego, California 92161, USA
    Fertil Steril 89:1200-8. 2008
    To evaluate serum adiponectin levels and organization into multimers in women with polycystic ovary syndrome (PCOS) and assess relationships between adiponectin, glucose tolerance, and insulin resistance.
  63. doi Adiponectin inhibits lymphotoxin-β receptor-mediated NF-κB signaling in human umbilical vein endothelial cells
    Yizhou Xu
    Department of Cardiology, Hangzhou the First People s Hospital, Hangzhou Hospital of Nanjing Medical University, Hangzhou 310006, China
    Biochem Biophys Res Commun 404:1060-4. 2011
    b>Adiponectin exerts anti-diabetic and anti-atherogenesis properties through its 2 receptors (AdipoR1 and AdipoR2). However, the signaling pathways responsible for the anti-inflammatory effects of adiponectin are largely unknown...
  64. doi Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population
    Nasser M Al-Daghri
    Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
    Gene 493:142-7. 2012
    In this study we examined the association of adiponectin gene variants with circulating adiponectin, and known metabolic diseases in 298 healthy controls and 297 Saudi subjects with type 2 diabetes mellitus (T2DM)...
  65. pmc A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome
    Kirsten E Peters
    School of Medicine and Pharmacology, Fremantle Hospital Unit, The University of Western Australia, Nedlands, Western Australia, Australia
    BMC Med Genet 14:15. 2013
    Low levels of serum adiponectin have been linked to central obesity, insulin resistance, metabolic syndrome, and type 2 diabetes...
  66. ncbi Anemia and reduced renal function are independent predictors of elevated serum adiponectin in elderly women
    Ayaka Tsuboi
    Postgraduate School of Food Sciences and Nutrition, Mukogawa Women s University, Hyogo 663 8558, Japan
    J Atheroscler Thromb 20:568-74. 2013
    Although higher adiponectin levels predict a low risk of type 2 diabetes, elevated adiponectin levels predict higher mortality in older persons.
  67. doi Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: family-based study
    F Zadjali
    College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
    Gene 527:663-9. 2013
    Plasma levels of adiponectin are decreased in type 2 diabetes, obesity and hypertension...
  68. ncbi Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin
    Hironori Waki
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655, Japan
    J Biol Chem 278:40352-63. 2003
    b>Adiponectin is an adipocyte-derived hormone, which has been shown to play important roles in the regulation of glucose and lipid metabolism...
  69. ncbi Adiponectin may play a part in the pathogenesis of diabetic retinopathy
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gulhane School of Medicine, Etlik Ankara, Turkey
    Eur J Endocrinol 151:135-40. 2004
    To measure plasma adiponectin concentrations in patients with type 2 diabetes and to investigate any association with the severity of diabetic retinopathy, because adiponectin seems to be an important modulator for metabolic and vascular ..
  70. ncbi Increased plasma adiponectin concentrations are associated with microangiopathy in type 1 diabetic subjects
    S Hadjadj
    Department of Endocrinology and Diabetology, University Hospital, BP 577, 86021, Poitiers Cedex, France
    Diabetologia 48:1088-92. 2005
    ..Patients with insulin resistance and/or macrovascular disease have abnormally low levels of adiponectin. The aim of this study was to investigate the relationships between adiponectin and renal and retinal diabetic ..
  71. ncbi Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology and Nutrition Research Unit, Dr Josep Trueta University Hospital of Girona, Carretera de Francia s n, 17007 Girona, Spain
    Metabolism 54:584-9. 2005
    ..The promoter region of the adiponectin gene--Apm1--encompasses consensus sequences for glucocorticosteroid receptor responsive element...
  72. ncbi Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males
    F F M Fisher
    Unit for Diabetes and Metabolism, Warwick Medical School, Clinical Sciences Research Institute, University of Warwick, UHCW Campus, Clifford Road, CV2 2DX, Coventry, UK
    Diabetologia 48:1084-7. 2005
    It is well established that total systemic adiponectin is reduced in type 2 diabetic subjects. To date most studies have been concerned with the singular full-length protein or proteolytically cleaved globular domain...
  73. ncbi Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus
    Alev E Altinova
    Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
    Gynecol Endocrinol 23:161-5. 2007
    b>Adiponectin and tumor necrosis factor-alpha (TNF-alpha) have been implicated in insulin resistance and diabetes mellitus (DM)...
  74. doi Serum levels of adiponectin are associated with diabetic retinopathy and with adiponectin gene mutations in Caucasian patients with diabetes mellitus type 2
    B Zietz
    Department of Internal Medicine II, Goldberg Klinik Kelheim GmbH, Germany
    Exp Clin Endocrinol Diabetes 116:532-6. 2008
    ..Since adiponectin represents an adipocyte-specific secretory protein modulating endothelial cell functions, it was the aim of the ..
  75. doi Adiponectin is associated with low bone mineral density in elderly men
    Lourdes Basurto
    Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Cuauhtémoc 06720 Mexico
    Eur J Endocrinol 160:289-93. 2009
    Recent evidence suggests that adiponectin may play a role in bone metabolism. Previous studies demonstrated that the adiponectin levels had a negative correlation with bone mineral density (BMD) in women...
  76. pmc Adiponectin and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study
    Anthony J G Hanley
    Department of Nutritional Sciences and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 34:2231-6. 2011
    A recent meta-analysis of 13 prospective studies reported that higher levels of adiponectin were significantly associated with lower risk of type 2 diabetes...
  77. pmc Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways
    Anna Koskinen
    The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Medisiinarinkatu 3, Tampere, FI 33014, Finland
    Arthritis Res Ther 13:R184. 2011
    b>Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation and arthritis...
  78. pmc Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    Zari Dastani
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
    PLoS Genet 8:e1002607. 2012
    Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits...
  79. doi The association studies of ADIPOQ with type 2 diabetes mellitus in Chinese populations
    Yiping Li
    Department of Endocrinology and Metabolism, The Second People s Hospital of Yunnan Province, Kunming, Yunnan, China
    Diabetes Metab Res Rev 28:551-9. 2012
    b>Adiponectin, which is secreted by the white adipose tissue, plays an important role in type 2 diabetes mellitus (T2DM) and its complications...
  80. doi High serum C1q-adiponectin/total adiponectin ratio correlates with coronary artery disease in Japanese type 2 diabetics
    Ayumu Hirata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Metabolism 62:578-85. 2013
    b>Adiponectin, an adipocyte-derived protein, has potential antiatherogenic properties. Low levels of serum total-adiponectin (Total-APN) correlate with diabetes and coronary artery disease (CAD)...
  81. pmc Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes
    Javier Conde
    NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Santiago de Compostela, Spain
    PLoS ONE 7:e52533. 2012
    ..There are several factors involved in the pathogenesis of these diseases including pro-inflammatory cytokines, adipokines and adhesion molecules...
  82. doi Increment and impairment of adiponectin in renal failure
    Noriyuki Komura
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Cardiovasc Res 86:471-7. 2010
    ..However, plasma adiponectin (APN) levels are increased in renal dysfunction...
  83. pmc Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness
    B Gwen Windham
    Department of Internal Medicine, Division of Geriatric Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 23:501-7. 2010
    ..adipocytes account for most adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness.
  84. ncbi Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery
    Christine Poitou
    INSERM Avenir EA 3502, Paris 6 University, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    Obes Surg 15:11-23. 2005
    ..Leptin, IL6 and adiponectin can be considered as adiposity signals...
  85. ncbi Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans
    Anthony J G Hanley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    J Clin Endocrinol Metab 92:2665-71. 2007
    ..Although associations of adiponectin with central obesity and insulin resistance have been reported, very little data are available from studies ..
  86. ncbi Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives
    I Truyen
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090, Brussels, Belgium
    Diabetologia 50:2143-6. 2007
    Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known ..
  87. ncbi Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes
    Lin Lin Li
    Department of Pharmacology, Xinjiang Medical University, Urumuqi, China
    Clin Exp Pharmacol Physiol 34:1287-90. 2007
    ..study was to investigate the association between the single nucleotide polymorphism (SNP) 45T/G and plasma adiponectin levels and the prevalence of Type 2 diabetes mellitus (T2DM) in Uygurs of the Xinjiang region, China. 2...
  88. pmc Adipokine genes and prostate cancer risk
    Steven C Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 124:869-76. 2009
    ..05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis...
  89. ncbi Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease
    Marina Miller
    Department of Medicine, University of California San Diego, San Diego, CA 92093, USA
    J Immunol 182:684-91. 2009
    ..pulmonary disease-Emphysema) and control subjects using a 120 Ab cytokine array and demonstrated that adiponectin was highly expressed in BAL in COPD-E...
  90. doi Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese
    Yabing Wang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Genet Genomics 36:417-23. 2009
    ..To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ..
  91. doi Low plasma adiponectin concentration is associated with myocardial infarction in young individuals
    J Persson
    Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden
    J Intern Med 268:194-205. 2010
    The importance of adiponectin in coronary heart disease remains to be elucidated...
  92. ncbi Association of the human adiponectin gene and insulin resistance
    Emanuela Filippi
    1Department of Clinical Sciences, Division of Endocrinology, University of Rome La Sapienza, Rome, Italy
    Eur J Hum Genet 12:199-205. 2004
    b>Adiponectin is an adipocyte-secreted protein that modulates insulin sensitivity and whose low circulating concentration is associated with insulin resistance...
  93. doi Identification of a regulatory single nucleotide polymorphism in the adiponectin (APM1) gene associated with type 2 diabetes in Han nationality
    Min Yang
    Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Biomed Environ Sci 21:454-9. 2008
    To identify the genetic defects of the the adiponectin (APM1) gene that contribute to the development of type 2 diabetes (T2DM) and determine the functional single nucleotide polymorphisms (SNPs) in the APM1 gene associated with T2DM in ..
  94. doi Common variation at the adiponectin locus is not associated with colorectal cancer risk in the UK
    Luis G Carvajal-Carmona
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Mol Genet 18:1889-92. 2009
    A recent study examined common genetic variants at the adiponectin locus (ADIPOQ) in two case-control colorectal cancer (CRC) series from the USA and reported a positive association between a single nucleotide polymorphism (SNP) in the 5'..
  95. doi Association of adiponectin, resistin, and vascular inflammation: analysis with 18F-fluorodeoxyglucose positron emission tomography
    Hae Yoon Choi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
    Arterioscler Thromb Vasc Biol 31:944-9. 2011
    b>Adiponectin and resistin are adipokines that are linked to obesity, inflammation, and atherosclerosis...
  96. ncbi Adiponectin is a better predictor of endothelial function of the coronary artery than HOMA-R, body mass index, immunoreactive insulin, or triglycerides
    Hideki Okui
    Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
    Int J Cardiol 126:53-61. 2008
    Previous studies have demonstrated that decreased levels of circulating adiponectin correlate with endothelial dysfunction in peripheral arteries...
  97. ncbi Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation
    Ram Weiss
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 88:2014-8. 2003
    We examined the impact of adolescent obesity on circulating adiponectin levels and the relationship between adiponectin and insulin sensitivity, intramyocellular (IMCL) lipid content, plasma triglycerides, and free fatty acids...
  98. ncbi Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    Utpal B Pajvani
    Department of Cell Biology, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:12152-62. 2004
    b>Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a hexamer of relatively low molecular weight (LMW) and a larger multimeric structure of high molecular weight (HMW)...
  99. pmc Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes
    Viktor A Potapov
    National Research Center GosNIIgenetika, 117545 Moscow, Russia
    Rev Diabet Stud 5:28-37. 2008
    Alterations in adiponectin-mediated pathways are known to be associated with glucose intolerance, insulin resistance (IR), obesity, and type 2 diabetes (T2D) mellitus...
  100. pmc Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study
    Hua Ling
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, Maryland, USA
    Obesity (Silver Spring) 17:737-44. 2009
    b>Adiponectin has a variety of metabolic effects on obesity, insulin sensitivity, and atherosclerosis...
  101. ncbi Globular adiponectin upregulates nitric oxide production in vascular endothelial cells
    Y Hattori
    Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Diabetologia 46:1543-9. 2003
    b>Adiponectin, also called ACRP30, is a novel adipose tissue-specific protein that has been shown to improve insulin sensitivity and to exert anti-atherogenic effects...

Research Grants76

  1. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ..between these measures and four inflammatory adipocytokines (interleukin-6, tumor necrosis factor - 1, leptin, adiponectin), CVD risk factors, and CAC...
  2. Metabolic Characterization of the Novel Adipokine CTRP3
    Jonathan Peterson; Fiscal Year: 2011
    ..Acrp30/Adiponectin is an insulin-sensitizing, multimeric protein produced by adipose tissue that plays a major role in regulating ..
  3. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..risk factors (Specific Aim #2: blood pressure, blood glucose, insulin, lipids, C-reactive protein, adiponectin, leptin, tumor necrosis factor-1, interleukin-6), functional status, and quality of life (Specific Aim #3: life ..
  4. Depression, Adipocytokines and Metabolic Dysregulation in Black and White Women
    Susan A Everson Rose; Fiscal Year: 2010
    ..Of specific interest in this application are adiponectin, an anti-inflammatory adipocytokine with insulin-sensitizing, anti-thrombotic and anti-atherogenic effects, and ..
  5. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2012
    ..Most strikingly, LCN2 regulates the adipocyte production of leptin and adiponectin. Our results lead to the hypothesis that LCN2 homeostatically regulates inflammatory response and insulin ..
  6. Andrew B Muir; Fiscal Year: 2014
    ..dysregulated adipose tissue, including insulin resistance (HOMA-IR, glucose clamp), circulating leptin and adiponectin, and markers of chronic inflammation (CRP, IL-6, TNF-[unreadable])...
  7. NICOLE LENORE MIHALOPOULOS; Fiscal Year: 2014
    ..Specifically, she will study how adiponectin and leptin, two adipokines that affect insulin resistance and lipid metabolism, and brown adipose tissue (BAT) ..
  8. Lei Cao; Fiscal Year: 2014
    ..switch, enhanced insulin sensitivity, resistance to diet-induced obesity (DIO), lower leptin level, higher adiponectin level and marked inhibition in melanoma and colon cancer growth...
  9. Timothy E McGraw; Fiscal Year: 2016
    ..g., leptin, adiponectin, etc.)...
  10. Childhood Precursors for Adulthood Metabolic Syndrome
    Shumei S Sun; Fiscal Year: 2010
    ..for body fat, fat distribution, fat-free mass, lipid profiles, insulin resistance, blood pressure, leptin, adiponectin and C-reactive protein (CRP) in relation to the presence or absence of the metabolic syndrome in adulthood;and, ..
  11. GUANG WILLIAM WONG; Fiscal Year: 2016
    ..One widely studied adipokine is adiponectin, well-known for being an insulin-sensitizer that promotes fatty acid oxidation in muscles and suppresses ..
  12. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..function (von Willebrand factor and E-selectin) and adipocytokines that represent insulin resistance (adiponectin, leptin, resistin, tumor necrosis factor-1, plasminogen activator inhibitor-1) and inflammation (C-reactive ..
  13. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..regulation of energy metabolism by enhancing b-cell proliferation, insulin production, insulin sensitivity and adiponectin expression as a feedback loop of Leptin's regulation of osteoblasts...
  14. Robert S Sherwin; Fiscal Year: 2014
    ..Using fMRI we plan to determine if obese adolescents, with relative low leptin and adiponectin in conjunction with high circulating insulin levels, might also display abnormal neuronal activity in certain ..
  15. Lisa Chasan-Taber; Fiscal Year: 2016
    ..e., glucose, insulin, HbA1c, leptin, TNF-, HOMA, AUCgluc, adiponectin), 3) other cardiovascular risk factors (i.e...
  16. Li Jiao; Fiscal Year: 2015
    ..Such interaction on adipocytes affects the secretion of adipokines, including adiponectin, leptin, PAI-1, and MCP1 that further contributes to obesity and insulin resistance...
  17. Paul F Pilch; Fiscal Year: 2015
    ..a variety of physiologically important proteins including the adipokines (adipose-derived cytokines) leptin and adiponectin. The assembly and secretion of these and other adipokines is initiated in the endoplasmic reticulum (E.R...
  18. DIET GLYCEMIC LOAD & METABOLISM IN OBESE PREGNANT WOMEN
    Janet King; Fiscal Year: 2009
    ..hormones involved in regulating fuel metabolism (human chorionic somatomammotropin, progesterone, leptin, adiponectin, prolactin, glucagon, cortisol, catecholamines, and ghrelin);and 3) to determine if consuming low GL diets the ..
  19. Mechanisms underlying adverse health consequences of shift work
    Frank A Scheer; Fiscal Year: 2013
    ..The principal dependent variables are derived from circulating adipocyte hormones (leptin, adiponectin, resistin, ghrelin), measures of insulin resistance (mixed meal response and intravenous glucose tolerance test)..
  20. Cohort Study of Biochemical and Genetic Risk Factors for Pancreatic Cancer
    BRIAN MATTHEW WOLPIN; Fiscal Year: 2013
    ..long-term systemic insulin exposure and two hormones altered in states of obesity and insulin resistance, adiponectin and leptin...
  21. Christos S Mantzoros; Fiscal Year: 2016
    ..Moreover, the PI is presenting some of his studies on the role of adiponectin as the link between obesity, insulin resistance and colon cancer, ranging from large observational cohort ..
  22. Long-term changes in weight and adipokines and the associations with genetic vari
    Lora E Burke; Fiscal Year: 2010
    ..from baseline to 24 months and their effect on insulin resistance (plasma insulin), adipokines (TNFalpha, IL-6, adiponectin, IL-10), and ghrelin and leptin;(2) describe the behaviors related to energy intake and energy expenditure and ..
  23. Philipp E Scherer; Fiscal Year: 2016
    ..In parallel, both the production and the release of the adipokine adiponectin are frequently impaired as well...
  24. Nada A Abumrad; Fiscal Year: 2016
    ..in cross adipose tissue where we showed that it influences PPARgamma activation and the secretion of leptin and adiponectin. Finally we documented the role of fatty acids and the transcription factor FoxO1 in regulation of CD36 ..
  25. Regulation of adipose tissue metabolism by central insulin and leptin
    Christoph Buettner; Fiscal Year: 2013
    ..endocrine organ that regulates energy homeostasis, glucose and lipid metabolism via adipokines like leptin and adiponectin, fatty acid release and possibly neuronal afferens...
  26. Kumaravel Rajakumar; Fiscal Year: 2016
    ..g. CRP, IL-6, TNF-alpha);(6) adipokines (leptin and adiponectin);and (7) nitric oxide metabolites. Brachial FMD at 6 months will be the primary outcome measure...
  27. David A Bernlohr; Fiscal Year: 2016
    ..of the metabolic syndrome including diminished adipocyte lipolysis, reduced TNF[unreadable] and increased adiponectin expression, improved insulin sensitivity, decreased NF-?B activation, protection from asthma and diminished ..
  28. Cynthia Cheng; Fiscal Year: 2014
    ..to date indicates that pro-inflammatory adipokines have a negative impact on microvascular function, while adiponectin has a protective effect on the microcirculation...
  29. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2011
    ..of the metabolic syndrome including diminished adipocyte lipolysis, reduced TNFαand increased adiponectin expression, improved insulin sensitivity, decreased NF-κB activation, protection from asthma and ..
  30. David E Harrison; Fiscal Year: 2014
    ..subcutaneous/visceral fat tissue distribution (using computerized tomography imaging);circulating adipokines (adiponectin, resistin, IL-6, and TNF-alpha);circulating and tissue levels of free fatty acids, triglyceride and cholesterol;..
  31. ERICA PAULINE GUNDERSON; Fiscal Year: 2014
    ..has lasting effects on cardio- metabolic risk factors, and biomarkers of insulin resistance and adiposity (adiponectin, IL-6, CRP, sICAM-1, leptin, sOB-R, TNF-1) that precede the onset of diabetes in women...
  32. Lu Qi; Fiscal Year: 2016
    ..key role in vascular disease, through secretion of adipocytokines, including retinol binding protein 4 (RBP4), adiponectin, and resistin, which are involved in inflammation and insulin resistance...
  33. Visceral Adiposity, HIV, and HCV: Biologic Mediators of Hepatic Steatosis
    Phyllis C Tien; Fiscal Year: 2013
    ..studies suggest that the consequences of visceral obesity (increased inflammatory cytokines, decreased adiponectin, insulin resistance, increased circulating free fatty acids or microbial translocation of gut-derived ..
  34. Adiponectin Actions on the Monocyte to Reduce Atherosclerosis
    Rajendra K Tangirala; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adiponectin, a hormone produced primarily by adipose tissue, has emerged as a therapeutic target for two major diseases of the Western World, diabetes and cardiovascular disease...
  35. ALEXANDER BANKS; Fiscal Year: 2014
    ..This phosphorylation correlates with dysregulation of PPAR-gamma target genes, such as adiponectin. Treatment of patients or mice with thiazolidinediones reverses phosphorylation as it improves insulin ..
  36. KRISTEN GILL HAIRSTON; Fiscal Year: 2014
    ..New assays of CRP, IL-6 and adiponectin will be conducted in stored specimens to obtain longitudinal measures of these biomarkers...
  37. Jerry Ingrande; Fiscal Year: 2015
    ..Adipose tissue is a highly metabolically active tissue and is responsible for the secretion of adiponectin, an adipokine with anti-inflammatory and insulin sensitizing properties...
  38. Tina E Brinkley; Fiscal Year: 2014
    ..e. adipokines). Of particular interest is adiponectin, which is expressed in both PCAT and PVAT and has potent effects on cardiovascular function and insulin action...
  39. Adipocyte insulin signaling and circulating adiponectin levels
    ROCIO INES PEREIRA; Fiscal Year: 2010
    ..Type 2 diabetes (T2DM), and the Metabolic Syndrome (MetS) are associated with low circulating levels of adiponectin, a protein produced exclusively by adipocytes...
  40. Regulation of energy metabolism by an osteoblast-specific gene
    Gerard Karsenty; Fiscal Year: 2010
    ..could detect in Esp-deficient mice were an hypoglycemia, an increase in insulin secretion, and an increase in adiponectin secretion resulting in an increase in insulin sensitivity...
  41. Christopher J Easley; Fiscal Year: 2016
    ..b>Adiponectin, a multimeric protein secreted by adipocytes, is one of the most abundantly secreted proteins in the body and ..
  42. Massimo Loda; Fiscal Year: 2016
    ..Our preliminary data demonstrate that low serum levels of adiponectin, an endogenous activator of AMPK, significantly predict poor PCa survival...
  43. Diet and Exercise in Type 2 Diabetes
    Kerry J Stewart; Fiscal Year: 2010
    ..include systemic inflammation, insulin sensitivity, aerobic and strength fitness, glycemic control, leptin, adiponectin, and cardiovascular disease risk factors...
  44. Lactation and Glucose Tolerance After GDM Pregnancy
    ERICA PAULINE GUNDERSON; Fiscal Year: 2011
    ..post load plasma glucose and insulin levels, indices of insulin resistance, body weight, waist girth and plasma adiponectin. Because randomization is not feasible, the rigorous assessment of lactation intensity and duration controlling ..
  45. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..to oxLDL, LpPLA2, sPLA2, myeloperoxidase);(2) insulin resistance and adiposity (insulin, C-peptide, adiponectin, leptin, resistin, liver function enzymes);(3) renal function (creatinine, cystatin C, ADMA, uric acid, 25(OH)..
  46. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..Specifically, a) Higher endogenous levels of c-peptide, insulin, leptin, and lower levels of adiponectin increase the risk of endometriosis...
  47. Lisa Chasan-Taber; Fiscal Year: 2016
    ..e., glucose, insulin, HbA1c, HOMA, leptin, adiponectin), 3) postpartum biomarkers of cardiovascular risk (i.e...
  48. Brian C Jacobson; Fiscal Year: 2014
    ..the associations between diet;gender;circulating levels of insulin, insulin derived growth factor, leptin, adiponectin, interleukin 6, tumor necrosis factor alpha, c-reactive protein, and other markers of insulin resistance and ..
  49. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..the production, secretion, and signaling of GI hormones (GLP-1, PYY, and ghrelin), and the adipocyte hormone, adiponectin and by altering bile acid metabolism and intestinal microflora...
  50. UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2015
    ..of Medicine in 2005, the latter degree earned in defining the biochemistry of the adipocyte-secreted hormone, adiponectin, and subsequently performed medical training in Internal Medicine and Endocrinology at Columbia University. Dr...
  51. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..of action of TZDs, their effects likely involve upregulation of the adipocyte-specific secretory molecule adiponectin (AcrpSO)...
  52. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..protein, serum amyloid A, interleukin-6), insulin like growth factor 1 and binding protein 3, and adipokines (adiponectin, leptin)...
  53. Kathryn M Rexrode; Fiscal Year: 2016
    ..Additionally, we will examine the adipocyte-derived adiponectin, and retinal binding protein 4 as risk predictors for ischemic stroke in women...
  54. Donald A McClain; Fiscal Year: 2016
    ..from increased glucose uptake in muscle mediated by activation of AMP-dependent kinase (AMPK) and increased adiponectin, without a change in overall adiposity;(B) Decreased glucose and increased fatty acid oxidation are seen, with ..
  55. OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCY
    Sylvie Hauguel De Mouzon; Fiscal Year: 2010
    ..Additionatty, w witl investigate the direct affect of n-3 pf4 on the expression of adiponectin and PPARy regulated genes in primary cuttured adipocytes...
  56. Qi Sun; Fiscal Year: 2016
    ..of insulin resistance/glucose metabolism abnormalities, including fasting insulin, hemoglobin-A1c, and total adiponectin, in young and middle-aged women who participated in a well-characterized prospective cohort: The Nurses'..
  57. Assiamira Ferrara; Fiscal Year: 2016
    ..Given the high cost of measuring BPA and metabolic biomarkers (glucose, insulin, adiponectin, GGT and ALT);we will obtain these measurements from 300 GDM cases and 600 controls to conduct a prospective, ..
  58. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
    ..obtained to characterize animals metabolically (serum concentrations of insulin, leptin, TNF-?, IL-6, and adiponectin)...
  59. Sheila Gahagan; Fiscal Year: 2016
    ..measure anthropometry, fat and muscle mass (DXA), fasting glucose, insulin (HOMA IR), lipids, leptin, ghrelin, adiponectin, orexin, CRP, and TNF alpha...
  60. Young Bum Kim; Fiscal Year: 2016
    ..successfully generated loxP flanked ROCK1 mice, which are currently being breed with mice expressing MCK-Cre or adiponectin-Cre recombinase producing muscle- or adipose-specific ROCK1-deficient mice...
  61. Adipokine Signaling in Macrophages
    Ling Qi; Fiscal Year: 2013
    ..g., adiponectin and resistin) secreted by adipocytes...
  62. Rotonya M Carr; Fiscal Year: 2016
    ..The research plan explores the novel hypothesis that Perilipin 2 (Plin2)- mediated lipid droplet biogenesis and adiponectin signaling are critically involved mechanistically in ceramide metabolism and insulin sensitivity in alcoholic ..
  63. HEME OXYGENASE REGULATION OF EICOSANOID BIOSYNTHESIS
    Nader G Abraham; Fiscal Year: 2013
    ..Previous work has identified the heme oxygenases (HO-1/HO-2), EETs and adiponectin as key endothelial protective molecules...
  64. Mechanisms of Vascular Dysfunction in Obesity & the Metabolic Syndrome
    ELAINE MOTT URBINA; Fiscal Year: 2010
    ..One of the pathways by which obesity induces target organ damage may involve fat derived adiponectin's (APN) effect on vascular function...
  65. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
    ..carcinogenesis by autocrine and paracrine actions mediated by two major adipocytokines, leptin and adiponectin. Our recent studies investigating the oncogenic actions of leptin revealed that - i) leptin induces ..
  66. Biomarkers of obesity inflammation and colon cancer risk
    JENIFER IMIG FENTON; Fiscal Year: 2010
    ..has demonstrated that some serum-derived biomarkers changing with adiposity, including leptin, IL-6, and adiponectin have profound effects on colon epithelial cells...
  67. Role of Genes in Exceptional Longevity in Humans
    NIR J BARZILAI; Fiscal Year: 2012
    ..in a single polymorphism in the Cholesterol ester transfer protein (CETP), Apolipoprotein C-3 (APOC-3), Adiponectin (ADIPOQ) genes...
  68. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ..obese, pregnant woman has increased serum levels of pro-inflammatory cytokines and low circulating levels of adiponectin leading to decreased insulin sensitivity, which has been suggested to link obesity in pregnancy to metabolic ..
  69. Trypanosoma cruzi and AIDS: Role of the Adipocyte
    Herbert Tanowitz; Fiscal Year: 2007
    ..Moreover, infection with this parasite profoundly alters glucose metabolism and adiponectin levels...
  70. Epidemiology and Incidence of Barrett's Esophagus
    DOUGLAS ALLEN CORLEY; Fiscal Year: 2010
    ..pathway between obesity and cancer may be through intermediary, adipose-associated hormones, such as leptin, adiponectin, ghrelin and insulin-like growth factors...
  71. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..and NSAID's and of insulinemia (weight and weight gain, dietary insulin index, plasma C-peptide, and adiponectin) will also be examined detail...
  72. Adiponectin regulates nutrient transport in the placenta
    Theresa L Powell; Fiscal Year: 2009
    ..The objective of this R03 application is to determine the role of adiponectin in regulating placental nutrient transport...
  73. Omega-3 Fatty Acids and Heart Failure
    William Stanley; Fiscal Year: 2009
    ..Fish oil intake also increased the cardioprotective hormone adiponectin in plasma, which we found correlated with prevention of cardiac dysfunction in pressure overloaded rats...
  74. MHC class II-Associated Endothelial Dysfunction
    Joseph Holoshitz; Fiscal Year: 2010
    ..is noteworthy that several known atherosclerosis-modulating proteins, such as C1q, mannose binding lectin and adiponectin, have all been previously shown to transduce signaling via cell surface CRT...

Patents1

  1. Use of OBG3 for promoting central nervous system remyelination
    Patent Number: WO03044057-A2; Date:2003-05-30