adiponectin

Summary

Gene Symbol: adiponectin
Description: adiponectin, C1Q and collagen domain containing
Alias: ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, adipose specific collagen-like factor, gelatin-binding protein 28
Species: human
Products:     adiponectin

Top Publications

  1. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...
  2. Tsubakio Yamamoto K, Matsuura F, Koseki M, Oku H, Sandoval J, Inagaki M, et al. Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages. Biochem Biophys Res Commun. 2008;375:390-4 pubmed publisher
    ..b>Adiponectin (APN) secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis...
  3. Tian L, Luo N, Klein R, Chung B, Garvey W, Fu Y. Adiponectin reduces lipid accumulation in macrophage foam cells. Atherosclerosis. 2009;202:152-61 pubmed publisher
    b>Adiponectin is one of several, important metabolically active cytokines secreted from adipocytes...
  4. Vetvik K, Sonerud T, Lindeberg M, Lüders T, Størkson R, Jonsdottir K, et al. Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies. Metabolism. 2014;63:672-81 pubmed publisher
    Low plasma adiponectin levels are linked to obesity, insulin resistance, and the risk of several types of malignancy...
  5. Donoso M, Muñoz Calvo M, Barrios V, Martinez G, Hawkins F, Argente J. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013;80:363-70 pubmed publisher
    ..We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) ..
  6. Ye E, Yang H, Chen L, Chen Q, Sun M, Lin Z, et al. Adiponectin and peroxisome proliferator-activated receptor-γ gene polymorphisms and gene-gene interactions with type 2 diabetes. Life Sci. 2014;98:55-9 pubmed publisher
    To investigate whether gene polymorphisms of both adiponectin and peroxisome proliferator-activated receptor gamma (PPARγ) influence type 2 diabetes mellitus (T2DM) respectively in the Han people of the Wenzhou region of China and ..
  7. Sulistyoningrum D, Gasevic D, Lear S, Ho J, Mente A, Devlin A. Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study. Cardiovasc Diabetol. 2013;12:170 pubmed publisher
    ..b>Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) ..
  8. Matharoo K, Arora P, Bhanwer A. Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab. Gene. 2013;527:228-34 pubmed publisher
    In Type 2 Diabetes (T2D), adiponectin (AdipoQ) and sulphonylurea receptor genes (ABCC8) are important targets for candidate gene association studies...
  9. Ahasic A, Zhao Y, Su L, Sheu C, Thompson B, Christiani D. Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. PLoS ONE. 2014;9:e89170 pubmed publisher
    b>Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness...
  10. Nakamura Y, Sekikawa A, Kadowaki T, Kadota A, Kadowaki S, Maegawa H, et al. Visceral and subcutaneous adiposity and adiponectin in middle-aged Japanese men: the ERA JUMP study. Obesity (Silver Spring). 2009;17:1269-73 pubmed publisher
    b>Adiponectin is reduced in obesity and has been suggested to play an important role in modulation of atherosclerosis...

Detail Information

Publications62

  1. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...
  2. Tsubakio Yamamoto K, Matsuura F, Koseki M, Oku H, Sandoval J, Inagaki M, et al. Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages. Biochem Biophys Res Commun. 2008;375:390-4 pubmed publisher
    ..b>Adiponectin (APN) secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis...
  3. Tian L, Luo N, Klein R, Chung B, Garvey W, Fu Y. Adiponectin reduces lipid accumulation in macrophage foam cells. Atherosclerosis. 2009;202:152-61 pubmed publisher
    b>Adiponectin is one of several, important metabolically active cytokines secreted from adipocytes...
  4. Vetvik K, Sonerud T, Lindeberg M, Lüders T, Størkson R, Jonsdottir K, et al. Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies. Metabolism. 2014;63:672-81 pubmed publisher
    Low plasma adiponectin levels are linked to obesity, insulin resistance, and the risk of several types of malignancy...
  5. Donoso M, Muñoz Calvo M, Barrios V, Martinez G, Hawkins F, Argente J. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013;80:363-70 pubmed publisher
    ..We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) ..
  6. Ye E, Yang H, Chen L, Chen Q, Sun M, Lin Z, et al. Adiponectin and peroxisome proliferator-activated receptor-γ gene polymorphisms and gene-gene interactions with type 2 diabetes. Life Sci. 2014;98:55-9 pubmed publisher
    To investigate whether gene polymorphisms of both adiponectin and peroxisome proliferator-activated receptor gamma (PPARγ) influence type 2 diabetes mellitus (T2DM) respectively in the Han people of the Wenzhou region of China and ..
  7. Sulistyoningrum D, Gasevic D, Lear S, Ho J, Mente A, Devlin A. Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study. Cardiovasc Diabetol. 2013;12:170 pubmed publisher
    ..b>Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) ..
  8. Matharoo K, Arora P, Bhanwer A. Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab. Gene. 2013;527:228-34 pubmed publisher
    In Type 2 Diabetes (T2D), adiponectin (AdipoQ) and sulphonylurea receptor genes (ABCC8) are important targets for candidate gene association studies...
  9. Ahasic A, Zhao Y, Su L, Sheu C, Thompson B, Christiani D. Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. PLoS ONE. 2014;9:e89170 pubmed publisher
    b>Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness...
  10. Nakamura Y, Sekikawa A, Kadowaki T, Kadota A, Kadowaki S, Maegawa H, et al. Visceral and subcutaneous adiposity and adiponectin in middle-aged Japanese men: the ERA JUMP study. Obesity (Silver Spring). 2009;17:1269-73 pubmed publisher
    b>Adiponectin is reduced in obesity and has been suggested to play an important role in modulation of atherosclerosis...
  11. Yilmaz M, Sonmez A, Acikel C, Celik T, Bingol N, Pinar M, et al. Adiponectin may play a part in the pathogenesis of diabetic retinopathy. Eur J Endocrinol. 2004;151:135-40 pubmed
    To measure plasma adiponectin concentrations in patients with type 2 diabetes and to investigate any association with the severity of diabetic retinopathy, because adiponectin seems to be an important modulator for metabolic and vascular ..
  12. Rodriguez Rodriguez L, Garcia Bermudez M, Gonzalez Juanatey C, Vazquez Rodriguez T, Miranda Filloy J, Fernandez Gutierrez B, et al. Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients. Tissue Antigens. 2011;77:74-8 pubmed publisher
    ..Therefore, ADIPOQ rs266729 and rs1501299 polymorphisms do not seem to be associated with cardiovascular disease in RA. ..
  13. Sharma A, Muddana V, Lamb J, Greer J, Papachristou G, Whitcomb D. Low serum adiponectin levels are associated with systemic organ failure in acute pancreatitis. Pancreas. 2009;38:907-12 pubmed publisher
    ..We tested the hypothesis that serum adiponectin, the primary anti-inflammatory adipokine, is associated with functional polymorphisms in the adiponectin gene (..
  14. Seino Y, Hirose H, Saito I, Itoh H. High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men. Metabolism. 2009;58:355-60 pubmed publisher
    b>Adiponectin is an adipocyte-specific secretory protein, which possesses antidiabetic and antiatherosclerotic properties...
  15. Wolf A, Wolf D, Rumpold H, Enrich B, Tilg H. Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun. 2004;323:630-5 pubmed
    ..The most abundant protein within the adipocyte is adiponectin. Our current work reports that adiponectin has potent immuno-suppressive properties, as it induces the ..
  16. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762-9 pubmed
    b>Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine...
  17. Gu H, Alvarsson A, Efendic S, Brismar K. SOX2 has gender-specific genetic effects on diabetic nephropathy in samples from patients with type 1 diabetes mellitus in the GoKinD study. Gend Med. 2009;6:555-64 pubmed publisher
    ..Furthermore, this SOX2 genetic polymorphism and the adiponectin promoter polymorphism rs266729 had combined effects on DN...
  18. Sanghera D, Demirci F, Been L, Ortega L, Ralhan S, Wander G, et al. PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor. Metabolism. 2010;59:492-501 pubmed publisher
    ..in peroxisome proliferator activated receptor-gamma transcripts 1 and 2 (PPARG1 and 2) and 5 tagSNPs in adiponectin (ADIPOQ) genes for their effect on type 2 diabetes mellitus (T2D) risk in Asian Indian Sikhs...
  19. Efstathiou S, Tsioulos D, Tsiakou A, Gratsias Y, Pefanis A, Mountokalakis T. Plasma adiponectin levels and five-year survival after first-ever ischemic stroke. Stroke. 2005;36:1915-9 pubmed
    This study aimed to investigate the association between plasma adiponectin levels and 5-year survival after first-ever ischemic stroke...
  20. Hug C, Wang J, Ahmad N, Bogan J, Tsao T, Lodish H. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A. 2004;101:10308-13 pubmed
    Acrp30/adiponectin is reduced in the serum of obese and diabetic individuals, and the genetic locus of adiponectin is linked to the metabolic syndrome...
  21. Kaklamani V, Sadim M, Hsi A, Offit K, Oddoux C, Ostrer H, et al. Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk. Cancer Res. 2008;68:3178-84 pubmed publisher
    Breast cancer risk is higher among obese women and women with diabetes. Adiponectin is a protein exclusively secreted by adipose tissue, circulating levels of which have been associated with breast cancer risk...
  22. Teixeira A, Diniz B, Campos A, Miranda A, Rocha N, Talib L, et al. Decreased levels of circulating adiponectin in mild cognitive impairment and Alzheimer's disease. Neuromolecular Med. 2013;15:115-21 pubmed publisher
    b>Adiponectin, an adipocytokine released by the adipose tissue and has important roles in the metabolic regulation and inflammatory control, may play an important roles in the physiopathology of psychiatric and neurodegenerative disorders...
  23. Wu Y, Li Y, Lange E, Croteau Chonka D, Kuzawa C, McDade T, et al. Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ. Hum Mol Genet. 2010;19:4955-64 pubmed publisher
    b>Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism...
  24. Saito K, Tobe T, Minoshima S, Asakawa S, Sumiya J, Yoda M, et al. Organization of the gene for gelatin-binding protein (GBP28). Gene. 1999;229:67-73 pubmed
    b>GBP28 is a novel human plasma gelatin-binding protein that is encoded by apM1 mRNA, expressed specifically in adipose tissue...
  25. Liu L, Zhong R, Wei S, Yin J, Xiang H, Zou L, et al. Interactions between genetic variants in the adiponectin, adiponectin receptor 1 and environmental factors on the risk of colorectal cancer. PLoS ONE. 2011;6:e27301 pubmed publisher
    ..To investigate whether polymorphisms of important adipokines, adiponectin (ADIPOQ) and its receptors, either alone or in combination with environmental factors, are implicated in ..
  26. Ruchat S, Despres J, Weisnagel S, Chagnon Y, Bouchard C, Perusse L. Genome-wide linkage analysis for circulating levels of adipokines and C-reactive protein in the Quebec family study (QFS). J Hum Genet. 2008;53:629-36 pubmed publisher
    ..We performed linkage analyses for fasting plasma levels of adiponectin, C-reactive protein (CRP), interleukin-6 (IL-6) and tumor-necrosis factor-alpha (TNF-alpha) in 764 subjects ..
  27. Tso A, Sham P, Wat N, Xu A, Cheung B, Rong R, et al. Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study. Diabetologia. 2006;49:1806-15 pubmed
    Polymorphisms of the gene encoding adiponectin (ADIPOQ) have previously been associated with type 2 diabetes in Europid and Japanese subjects, but not in Pima Indians...
  28. Filippi E, Sentinelli F, Trischitta V, Romeo S, Arca M, Leonetti F, et al. Association of the human adiponectin gene and insulin resistance. Eur J Hum Genet. 2004;12:199-205 pubmed
    b>Adiponectin is an adipocyte-secreted protein that modulates insulin sensitivity and whose low circulating concentration is associated with insulin resistance...
  29. Daimon M, Oizumi T, Saitoh T, Kameda W, Hirata A, Yamaguchi H, et al. Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care. 2003;26:2015-20 pubmed
    To examine whether decreased serum levels of adiponectin are an independent risk factor for the progression to type 2 diabetes in a Japanese population...
  30. So W, Tong P, Ko G, Ma R, Ozaki R, Kong A, et al. Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic beta-cell function. Diabetes Res Clin Pract. 2009;86:89-95 pubmed publisher
    b>Adiponectin is an adipocytokine with insulin sensitizing effect while chronic inflammation damages pancreatic beta-cells leading to reduced insulin response...
  31. Andreasson A, Undén A, Elofsson S, Brismar K. Leptin and adiponectin: distribution and associations with cardiovascular risk factors in men and women of the general population. Am J Hum Biol. 2012;24:595-601 pubmed publisher
    ..prevalence of obesity worldwide, understanding the role of the recently discovered adipokines leptin and adiponectin is of high clinical relevance...
  32. Tong K, Chen C, Huang K, Shieh D, Cheng H, Tzeng C, et al. Adiponectin increases MMP-3 expression in human chondrocytes through AdipoR1 signaling pathway. J Cell Biochem. 2011;112:1431-40 pubmed publisher
    Articular adipose tissue is a ubiquitous component of human joints, and adiponectin is a protein hormone secreted predominantly by differentiated adipocytes and involved in energy homeostasis...
  33. Kangas Kontio T, Huotari A, Ruotsalainen H, Herzig K, Tamminen M, Ala Korpela M, et al. Genetic and environmental determinants of total and high-molecular weight adiponectin in families with low HDL-cholesterol and early onset coronary heart disease. Atherosclerosis. 2010;210:479-85 pubmed publisher
    Plasma adiponectin and high-density lipoprotein cholesterol (HDL-C) exhibit a well-known positive metabolic correlation. Neither heritability nor genome-wide linkage analysis for the high-molecular weight (HMW) adiponectin is available...
  34. Siitonen N, Pulkkinen L, Lindström J, Kolehmainen M, Eriksson J, Venojarvi M, et al. Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study. BMC Med Genet. 2011;12:5 pubmed publisher
    b>Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-sensitising and anti-atherogenic effects. Human adiponectin is encoded by the ADIPOQ gene on the chromosomal locus 3q27...
  35. Pischon T, Pai J, Manson J, Hu F, Rexrode K, Hunter D, et al. Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women. Obesity (Silver Spring). 2007;15:2051-60 pubmed
    The objective was to examine the association of 5 common single nucleotide polymorphisms (SNPs) at the adiponectin locus with risk of coronary heart disease (CHD) in men and women...
  36. Choi H, Kim S, Yang S, Yoo H, Seo J, Kim S, et al. Association of adiponectin, resistin, and vascular inflammation: analysis with 18F-fluorodeoxyglucose positron emission tomography. Arterioscler Thromb Vasc Biol. 2011;31:944-9 pubmed publisher
    b>Adiponectin and resistin are adipokines that are linked to obesity, inflammation, and atherosclerosis...
  37. Ukkola O, Ravussin E, Jacobson P, Sjöström L, Bouchard C. Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort. Metabolism. 2003;52:881-4 pubmed
    b>Adiponectin (also called AdipoQ, gelatin-binding protein 28, Acrp30) DNA sequence variants were determined in 96 unrelated female subjects with severe obesity (mean body mass index [BMI], 42...
  38. Liang K, Sheu W, Lee W, Liu T, Ting C, Hsieh Y, et al. Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris. Int J Cardiol. 2008;129:76-80 pubmed
    Adipocyte cytokines regulate glucose metabolism and insulin resistance and adiponectin is thought to have a protective effect against atherosclerosis...
  39. Huang C, Lee C, Chen M, Tsai H, Hsu H, Tang C. Adiponectin increases BMP-2 expression in osteoblasts via AdipoR receptor signaling pathway. J Cell Physiol. 2010;224:475-83 pubmed publisher
    b>Adiponectin is a protein hormone secreted predominantly by differentiated adipocytes and involved in energy homeostasis. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation...
  40. Hivert M, Manning A, McAteer J, Florez J, Dupuis J, Fox C, et al. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes. 2008;57:3353-9 pubmed publisher
    Variants in ADIPOQ have been inconsistently associated with adiponectin levels or diabetes...
  41. Inoue M, Maehata E, Yano M, Taniyama M, Suzuki S. Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism. 2005;54:281-6 pubmed
    We studied the correlation between the adiponectin-leptin (A/L) ratio and parameters of insulin resistance in 220 Japanese patients with type 2 diabetes (138 men and 82 women)...
  42. Côté M, Mauriege P, Bergeron J, Almeras N, Tremblay A, Lemieux I, et al. Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men. J Clin Endocrinol Metab. 2005;90:1434-9 pubmed
    The present study examined the associations between a major adipokine, adiponectin, and adiposity indices as well as metabolic risk variables in a sample of 190 untreated asymptomatic men...
  43. Lakota K, Wei J, Carns M, Hinchcliff M, Lee J, Whitfield M, et al. Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?. Arthritis Res Ther. 2012;14:R102 pubmed publisher
    ..Here we evaluated the levels of adiponectin, a sensitive and specific index of PPAR-gamma activity, as a potential fibrogenic biomarker in SSc...
  44. Iacobellis G, di Gioia C, di Gioia C, Cotesta D, Petramala L, Travaglini C, et al. Epicardial adipose tissue adiponectin expression is related to intracoronary adiponectin levels. Horm Metab Res. 2009;41:227-31 pubmed publisher
    The role of adiponectin and epicardial adipose tissue in coronary artery disease (CAD) is a subject of debate...
  45. Park P, Huang H, McMullen M, Mandal P, Sun L, Nagy L. Suppression of lipopolysaccharide-stimulated tumor necrosis factor-alpha production by adiponectin is mediated by transcriptional and post-transcriptional mechanisms. J Biol Chem. 2008;283:26850-8 pubmed publisher
    b>Adiponectin is an adipokine with potent anti-inflammatory properties. Treatment of macrophages with adiponectin results in a suppression of lipopolysaccharide (LPS)-stimulated cytokine production...
  46. Esteghamati A, Mansournia N, Nakhjavani M, Mansournia M, Nikzamir A, Abbasi M. Association of +45(T/G) and +276(G/T) polymorphisms in the adiponectin gene with coronary artery disease in a population of Iranian patients with type 2 diabetes. Mol Biol Rep. 2012;39:3791-7 pubmed publisher
    The relation of Two single nucleotide polymorphisms (SNPs) at the adiponectin locus (+45T/G and +276G/T) with coronary artery disease (CAD) is controversial...
  47. Lara Castro C, Luo N, Wallace P, Klein R, Garvey W. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes. 2006;55:249-59 pubmed
    b>Adiponectin circulates in human plasma mainly as a 180-kDa low molecular weight (LMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa...
  48. Ishikawa M, Kitayama J, Kazama S, Hiramatsu T, Hatano K, Nagawa H. Plasma adiponectin and gastric cancer. Clin Cancer Res. 2005;11:466-72 pubmed
    ..b>Adiponectin is a peptide hormone secreted by adipose tissue, affecting the proliferation and insulin sensitivity of various ..
  49. Menzaghi C, Ercolino T, Di Paola R, Berg A, Warram J, Scherer P, et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes. 2002;51:2306-12 pubmed
    b>Adiponectin is a protein secreted by adipocytes that modulates insulin action...
  50. Dhillon P, Penney K, Schumacher F, Rider J, Sesso H, Pollak M, et al. Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2011;20:2618-27 pubmed publisher
    b>Adiponectin, an insulin-sensitizing adipokine, is inversely associated with adiposity and prostate cancer risk and progression...
  51. Lewandowski K, Szosland K, O Callaghan C, Tan B, Randeva H, Lewinski A. Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices. Mol Genet Metab. 2005;85:61-9 pubmed
    ..In contrast, adiponectin, increases insulin sensitivity, improves glucose tolerance, inhibits inflammatory pathways, while adenovirus-..
  52. Gu H, Abulaiti A, Ostenson C, Humphreys K, Wahlestedt C, Brookes A, et al. Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians. Diabetes. 2004;53 Suppl 1:S31-5 pubmed
    b>Adiponectin (APM1) is an adipocyte-derived peptide. The APM1 gene is located on chromosome 3q27 and linked to type 2 diabetes...
  53. Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali S, et al. Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab. 2003;88:2014-8 pubmed
    We examined the impact of adolescent obesity on circulating adiponectin levels and the relationship between adiponectin and insulin sensitivity, intramyocellular (IMCL) lipid content, plasma triglycerides, and free fatty acids...
  54. Costacou T, Zgibor J, Evans R, Otvos J, Lopes Virella M, Tracy R, et al. The prospective association between adiponectin and coronary artery disease among individuals with type 1 diabetes. The Pittsburgh Epidemiology of Diabetes Complications Study. Diabetologia. 2005;48:41-8 pubmed
    Recent findings suggest the potential involvement of adiponectin in obesity, diabetes and cardiovascular disease...
  55. Vaiopoulos A, Marinou K, Christodoulides C, Koutsilieris M. The role of adiponectin in human vascular physiology. Int J Cardiol. 2012;155:188-93 pubmed publisher
    b>Adiponectin (ApN) is an adipose tissue-derived hormone which is involved in a wide variety of physiological processes including energy metabolism, inflammation, and vascular physiology via actions on a broad spectrum of target organs ..
  56. Crawford L, Peake R, Price S, Morris T, Irvine A. Adiponectin is produced by lymphocytes and is a negative regulator of granulopoiesis. J Leukoc Biol. 2010;88:807-11 pubmed publisher
    ..b>Adiponectin is an adipokine that has been demonstrated to act as a negative regulator of hematopoiesis and immune function...
  57. Koh S, Park J, Yoon J, Chang S, Oh S, Kim J, et al. Preliminary report: a serious link between adiponectin levels and metabolic syndrome in a Korean nondiabetic population. Metabolism. 2010;59:333-7 pubmed publisher
    This large-scale cross-sectional investigation highlights the relationships between adiponectin levels and a number of metabolic syndrome components in a nondiabetic Korean population (N = 6634)...
  58. Plant S, Shand B, Elder P, Scott R. Adiponectin attenuates endothelial dysfunction induced by oxidised low-density lipoproteins. Diab Vasc Dis Res. 2008;5:102-8 pubmed publisher
    We investigated whether the adipocytokine, adiponectin, protected the endothelium against damage induced by oxidised low-density lipoprotein cholesterol (oxLDL)...
  59. Guo X, Saad M, Langefeld C, Williams A, Cui J, Taylor K, et al. Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study. Diabetes. 2006;55:1723-30 pubmed
    b>Adiponectin (APM1) is an adipocyte-derived peptide that contributes to glucose, lipid, and energy homeostasis...
  60. Wannamethee S, Welsh P, Whincup P, Sawar N, Thomas M, Gudnarsson V, et al. High adiponectin and increased risk of cardiovascular disease and mortality in asymptomatic older men: does NT-proBNP help to explain this association?. Eur J Cardiovasc Prev Rehabil. 2011;18:65-71 pubmed publisher
    Raised adiponectin is associated with increased rather than decreased risk of cardiovascular disease (CVD) and mortality at older age...
  61. Hwang M, Yu N, Stinson S, Yue P, Newman R, Allan B, et al. miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer. PLoS ONE. 2013;8:e66502 pubmed publisher
    ..We identified adiponectin receptor 1 (ADIPOR1), a receptor for the adipocytokine adiponectin, as a direct target of miR-221/222...