alpha 2 macroglobulin

Summary

Gene Symbol: alpha 2 macroglobulin
Description: alpha-2-macroglobulin
Alias: A2MD, CPAMD5, FWP007, S863-7, alpha-2-macroglobulin, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, alpha-2-M
Species: human

Top Publications

  1. ncbi ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix
    K Kuno
    Department of Molecular Pharmacology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 274:18821-6. 1999
  2. ncbi Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
    Geza Ambrus
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 170:1374-82. 2003
  3. ncbi Identification of alpha 2-macroglobulin as a cytokine binding plasma protein. Binding of interleukin-1 beta to "F" alpha 2-macroglobulin
    W Borth
    Institute of Immunology, University of Vienna, Austria
    J Biol Chem 264:5818-25. 1989
  4. ncbi Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands
    Y Liu
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Nat Med 6:1380-7. 2000
  5. ncbi Alpha-1 antichymotrypsin and alpha-2 macroglobulin gene polymorphisms are not associated with Korean late-onset Alzheimer's disease
    C S Ki
    Department of Clinical Pathology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Ilwon Dong, Kangnam Gu, 135 710, Seoul, South Korea
    Neurosci Lett 302:69-72. 2001
  6. ncbi Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin
    Yue Zhang
    Program in Cellular and Molecular Biology, The Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 281:39096-104. 2006
  7. ncbi Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics
    W Borth
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029
    FASEB J 6:3345-53. 1992
  8. ncbi The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction
    Uma K Misra
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:42082-7. 2002
  9. pmc Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK
    Uma Kant Misra
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:26278-86. 2005
  10. ncbi Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity
    Mark R Wilson
    School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
    Mol Biosyst 4:42-52. 2008

Research Grants

  1. LRP AND ALZHEIMER'S DISEASE
    Bradley T Hyman; Fiscal Year: 2011
  2. GENETIC EPIDEMIOLOGY OF ALZHEIMER'S DISEASE IN TWINS
    Brenda Plassman; Fiscal Year: 2003
  3. Alpha2-Macroglobulin-PA Complexes: Novel Anthrax Vaccin*
    SALVATORE PIZZO; Fiscal Year: 2003
  4. Regulation of Growth Factor Activity by A2 Macroglobulin
    STEVEN GONIAS; Fiscal Year: 2005
  5. REGULATION OF PROTEASE ACTIVITY BY ALPHA 2-MACROGLOBULIN
    Dudley Strickland; Fiscal Year: 1992
  6. ENVIRONMENTAL MODULATION OF FIBRINOLYSIS INHIBITORS
    STEVEN GONIAS; Fiscal Year: 1992
  7. Mechanisms of beta2-microglubin in Autoimmune Diabetes
    STANLEY NATHENSON; Fiscal Year: 2006
  8. REGULATORY EVENTS IN FIBRINOLYSIS & COAGULATION
    Dudley Strickland; Fiscal Year: 1992
  9. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
  10. COMPARATIVE DNA SEQUENCE VARIATION IN ALZHEIMER GENES
    John Ely; Fiscal Year: 2002

Detail Information

Publications225 found, 100 shown here

  1. ncbi ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix
    K Kuno
    Department of Molecular Pharmacology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 274:18821-6. 1999
    ..Consequently, ADAMTS-1 is an active metalloprotease that is associated with the extracellular matrix. This study strongly suggests that ADAMTS-1 may play a role in the inflammatory process through its protease activity...
  2. ncbi Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
    Geza Ambrus
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 170:1374-82. 2003
    ..Nevertheless, relative rates of reaction with alpha-2-macroglobulin and C1-inhibitor suggest that alpha-2-macroglobulin may be a significant physiological inhibitor of MASP-1...
  3. ncbi Identification of alpha 2-macroglobulin as a cytokine binding plasma protein. Binding of interleukin-1 beta to "F" alpha 2-macroglobulin
    W Borth
    Institute of Immunology, University of Vienna, Austria
    J Biol Chem 264:5818-25. 1989
    ....
  4. ncbi Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands
    Y Liu
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Nat Med 6:1380-7. 2000
    ..These results indicate that HIV-1 Tat may mediate HIV-1-induced neuropathology through a pathway involving disruption of the metabolic balance of LRP ligands and direct activation of neuronal genes...
  5. ncbi Alpha-1 antichymotrypsin and alpha-2 macroglobulin gene polymorphisms are not associated with Korean late-onset Alzheimer's disease
    C S Ki
    Department of Clinical Pathology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Ilwon Dong, Kangnam Gu, 135 710, Seoul, South Korea
    Neurosci Lett 302:69-72. 2001
    ..Our results do not support previously reported association of ACT and A2M with LOAD, at least in Korean population...
  6. ncbi Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin
    Yue Zhang
    Program in Cellular and Molecular Biology, The Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 281:39096-104. 2006
    ..These findings suggest possible therapeutic interventions involving ectopic expression of modified versions of alpha(2)-macroglobulin in the treatment of fibrotic conditions...
  7. ncbi Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics
    W Borth
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029
    FASEB J 6:3345-53. 1992
    ....
  8. ncbi The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction
    Uma K Misra
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:42082-7. 2002
    ....
  9. pmc Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK
    Uma Kant Misra
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:26278-86. 2005
    ..These studies suggest a mechanism by which alpha2M* enhances the metastatic potential of these cells...
  10. ncbi Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity
    Mark R Wilson
    School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
    Mol Biosyst 4:42-52. 2008
    ..Further advances in understanding of the mechanisms that control extracellular protein folding are likely to identify new strategies for effective disease therapies...
  11. doi Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity
    Katie French
    School of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    Biochemistry 47:1176-85. 2008
    ..We propose that alpha2M is a newly discovered and unique member of a small group of abundant extracellular proteins with chaperone properties that patrol extracellular spaces for unfolded/misfolded proteins and facilitate their disposal...
  12. doi alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species
    Justin J Yerbury
    School of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, New South Wales 2522, Australia
    J Biol Chem 284:4246-54. 2009
    ..These findings suggest that both alpha(2)M and Hp are likely to play an important role in controlling the inappropriate aggregation of proteins in the extracellular environment...
  13. ncbi Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis
    Poul Erik H Jensen
    The Neuroimmunology Laboratory, Section 9302, MS Research Unit, Copenhagen University Hospital, Juliane Mariesvej 20, 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1690:203-7. 2004
    ..The results suggest an important involvement of alpha2M in regulation of increased proteolytic activity occurring in MS disease...
  14. ncbi Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1
    Sanja Arandjelovic
    Department of Pathology, University of California San Diego, 9500 Gilman Road, La Jolla, CA 92093 0612, USA
    Arch Biochem Biophys 438:29-35. 2005
    ..7 cells was blocked by receptor-associated protein, indicating an essential role for LRP-1. These studies demonstrate that a single mutation in full-length r(alpha)2M is sufficient to block binding to LRP-1...
  15. ncbi Polymyxin B-conjugated alpha 2-macroglobulin as an adjunctive therapy to sepsis: Modes of action and impact on lethality
    Gerd Birkenmeier
    Institute of Biochemistry, University of Leipzig, Leipzig, Germany
    J Pharmacol Exp Ther 318:762-71. 2006
    ..These results support our hypothesis that A2M-PMB acts as a polyvalent drug to target different host mediators as well as sepsis inducer at the same time...
  16. ncbi Alpha-2-macroglobulin receptor is differently expressed in peritoneal macrophages from C3H and C57/B16 mice and up-regulated during Trypanosoma cruzi infection
    C M Coutinho
    Lab Biologia Celular, DUBC, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    Tissue Cell 30:407-15. 1998
    ..Finally, our results indicate that as macrophages become activated in vivo a higher expression of A2M-R is observed...
  17. doi Multiple forms of alpha-2 macroglobulin in shrimp Fenneropenaeus chinesis and their transcriptional response to WSSV or Vibrio pathogen infection
    Hongming Ma
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
    Dev Comp Immunol 34:677-84. 2010
    ..These expression features indicate that the different types of A2M in F. chinesis carry out different functions and that they are not simply functionally redundant...
  18. pmc Surfactant protein D interacts with alpha2-macroglobulin and increases its innate immune potential
    Hayley A Craig-Barnes
    Lung Innate Immunity Research Laboratory, Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 285:13461-70. 2010
    ..These interactions particularly enhance bacterial agglutination and immune complex formation...
  19. ncbi A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis
    Marie Florence Galliano
    UMR 5165, Epidermis Differentiation and Rheumatoid Autoimmunity, CNRS Toulouse III University IFR 30, INSERM CNRS Toulouse III University CHU, 31073 Toulouse, France
    J Biol Chem 281:5780-9. 2006
    ..Therefore, alpha2ML1 is the first alpha2M family member detected in the epidermis. It may play an important role during desquamation by inhibiting extracellular proteases...
  20. ncbi Lack of site-specific production of decidual alpha-2 macroglobulin in human pregnancy
    Shing Shun Nelson Siu
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Soc Gynecol Investig 13:491-6. 2006
    ..The aim of the current study was to determine and compare A2M production from first trimester human decidua basalis and decidua parietalis...
  21. ncbi Detection of an alteration of the alpha 2-macroglobulin gene in a patient with chronic lung disease and serum alpha 2-macroglobulin deficiency
    W Poller
    Medizinische Universitatsklinik, Klinikum Bergmannsheil, Ruhr Universitat, Bochum, Federal Republic of Germany
    Hum Genet 83:93-6. 1989
    ..The patient is heterozygous for an alteration in the A2M gene; this may be responsible for his serum A2M deficiency and may be relevant to the early onset of pulmonary disease in his case...
  22. ncbi Transplacental transport of alpha 2-macroglobulin (alpha 2M) and induction of alpha 2M in maternal and neonatal rats with acute inflammation
    Makoto Shimizu
    Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Exp Anim 51:361-5. 2002
    ..It was demonstrated that induction of alpha 2M in neonatal rats was lower than in maternal rats when inoculated with turpentine oil. These results suggest that alpha 2M is transplacentally transported from maternal rats to fetal ones...
  23. ncbi Alpha-2 macroglobulin is genetically associated with Alzheimer disease
    D Blacker
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
    Nat Genet 19:357-60. 1998
    ....
  24. ncbi Effects of tobacco smoking on alpha-2-macroglobulin and some biochemical parameters in Thai males
    Kanjana Suriyaprom
    Faculty of Medical Technology, Rangsit University, Pathum Thani, Thailand
    Southeast Asian J Trop Med Public Health 38:918-26. 2007
    ..This effect may be the mechanism responsible for the development of chronic disease states associated with smoking since cigarette smoke contains many toxic compounds harmful to health...
  25. doi Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease
    Elisa Bruno
    Dipartimento di Neuroscienze, Universita di Catania, Via Santa Sofia 78, 95123 Catania, Italy
    Neurosci Lett 482:112-6. 2010
    ..No evidence of significant interaction has been found between the studied polymorphisms (p>0.05). In conclusion our study suggests that LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD...
  26. doi Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades
    C J Carter
    Neurochem Int 52:920-34. 2008
    ....
  27. pmc Participating in the evolution of transfusion medicine from a dispensary into a discipline
    Girish N Vyas
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Transfus Med Rev 22:162-7. 2008
    ..The TM training and research programs I initiated at UCSF in the 1980s with National Institutes of Health support enabled me to recruit new faculty members who continue to foster the worldwide advancement of transfusion safety...
  28. ncbi Long-term durability of the dual-cure resin cement/silicon oxide ceramic bond
    Richard M Foxton
    Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, Japan
    J Adhes Dent 4:125-35. 2002
    ..To determine the effects of using a ceramic primer, ceramic bonding agent, or a combination of primer/bonding agent on the long-term durability of the dual-cure resin cement/silicon oxide ceramic bond...
  29. ncbi A novel panel of blood markers to assess the degree of liver fibrosis
    Paul Cales
    Laboratoire HIFIH, UPRES 3859, IFR 132, Universite, Angers, France
    Hepatology 42:1373-81. 2005
    ..Whereas the Fibrometer has a high diagnostic accuracy for clinically significant fibrosis, blood tests for the area of liver fibrosis provide a quantitative estimation of the amount of fibrosis, which is especially useful in cirrhosis...
  30. ncbi Pharmacogenomics for the treatment of dementia
    Ramon Cacabelos
    From the EuroEspes Biomedical Research Center, Institute for CNS Disorders, Bergondo, La Coruna, Spain
    Ann Med 34:357-79. 2002
    ..The pharmacogenomics of AD may contribute in the future to optimise drug development and therapeutics, increasing efficacy and safety, and reducing side-effects and unnecessary costs...
  31. ncbi Genomics and phenotypic profiles in dementia: implications for pharmacological treatment
    R Cacabelos
    EuroEspes Biomedical Research Center, Institute for CNS Disorders, EuroEspes Biotechnology EBIOTEC, Coruna, Spain
    Methods Find Exp Clin Pharmacol 26:421-44. 2004
    ....
  32. ncbi [Influence of moxibustion on JAK-STAT signal transduction pathways of synovial cells in rheumatoid arthritis rabbits]
    Xin Yang
    Chengdu University of Chinese Medicine, Chengdu 610075, China
    Zhen Ci Yan Jiu 32:75-82. 2007
    ....
  33. ncbi Phenotypic profiles and functional genomics in Alzheimer's disease and in dementia with a vascular component
    Ramon Cacabelos
    EuroEspes Biomedical Research Center, Institute for CNS Disorders, EuroEspes Biotechnology EBIOTEC, Coruna, Spain and Department of Biotechnology and Genomics, Camilo José Cela University, Madrid, Spain
    Neurol Res 26:459-80. 2004
    ....
  34. ncbi Diagnostic and epidemiological implications of regional differences in serum concentrations of proteins observed in six Asian cities
    Kiyoshi Ichihara
    Department of Clinical Laboratory Sciences, Yamaguchi University, Ube, Japan
    Clin Chem Lab Med 42:800-9. 2004
    ..Slight age-related differences were observed, irrespective of the region, in IgA and ceruloplasmin (increase) and A2M (decrease). Environmental factors and lifestyle seem to have a great influence on many commonly measured analytes...
  35. ncbi Genomic characterization of Alzheimer's disease and genotype-related phenotypic analysis of biological markers in dementia
    Ramon Cacabelos
    EuroEspes Chair of Biotechnology and Genomics, Camilo José Cela University, Madrid, Spain
    Pharmacogenomics 5:1049-105. 2004
    ..All these genotypic and phenotypic variations bring about important consequences for the pharmacogenomics of AD...
  36. doi Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease
    Madhav Thambisetty
    King s College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    J Neurol 255:1712-20. 2008
    ..We also undertook a proteomic analysis of plasma in these individuals using two-dimensional gel electrophoresis (2DGE)...
  37. ncbi A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2
    M Renedo
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Madrid, 28006, Spain
    Genomics 65:129-36. 2000
    ..This map would facilitate the cloning of new KLR genes and the complete sequencing of this region...
  38. ncbi A sensitive radioimmunoassay of insulin autoantibody: reduction of non-specific binding of [125I]insulin
    Hiroshi Murayama
    Immunology Laboratory, Diagnostics Department, Yamasa Corporation, 2 10 1 Araoi cho, Choshi, Chiba 288 0056, Japan
    J Autoimmun 26:127-32. 2006
    ..7% and 30.9% with or without insulin competition, respectively, whereas that of the former assay without ProClin300 was only 20.0%...
  39. pmc Optimizing screening for acute human immunodeficiency virus infection with pooled nucleic acid amplification tests
    Daniel J Westreich
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Microbiol 46:1785-92. 2008
    ..Used selectively and carefully, the simple models developed here can guide the selection of a pooling algorithm for the detection of AHI cases in a wide variety of settings...
  40. doi Association between haplotype -88G/25G in A2M with Alzheimer's disease
    Haiqing Song
    Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Key Neurodegenerative Laboratory of Ministry of Education of the People s Republic of China, Beijing 100053, PR China
    Neurosci Lett 479:143-5. 2010
    ..77, 95%CI 1.06-2.96, P=0.027). Our study supports that haplotype -88G/25G might play a protective role in the development of SAD, and the protective effects of -88G and 25G were independent of APOEvarepsilon4 allele...
  41. ncbi Circulating alpha-2-macroglobulin levels and depression scores in patients who underwent abdominal cancer surgery
    Tetsuji Fujita
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    J Surg Res 114:90-4. 2003
    ..Relevance of elevated levels of serum of alpha-2-macroglobulin (A2M) to psychological depression has been recently suggested...
  42. ncbi Trypanosoma cruzi: alpha-2-macroglobulin regulates host cell apoptosis induced by the parasite infection in vitro
    E M De Souza
    Lab Biologia Celular, Departamento de Ultra estrutura e Biologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Avenida Brasil 4365, Manguinhos, 21045 900 Rio de Janeiro, RJ, Brazil
    Exp Parasitol 118:331-7. 2008
    ..In addition, macrophages from C57/BL6 mice, known to display higher LRP levels as compared to those of C3H lineage, displayed higher reduction in the apoptotic levels during the A2M-F treatment...
  43. ncbi A putative homoeolog of human chromosome 12 in the owl monkey
    N S Ma
    New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772
    Cytogenet Cell Genet 50:34-9. 1989
    ..The morphological differences between these two primate chromosomes indicate evolutionary rearrangements involving at least one pericentric inversion...
  44. pmc Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma
    C Falkenberg
    Department of Medical and Physiological Chemistry, University of Lund, Sweden
    Biochem J 301:745-51. 1994
    ..The existence of a complex between alpha 1-m and fibronectin in rats and humans suggests a mechanism for the incorporation of the immunoregulatory molecule alpha 1-m into the extracellular matrix...
  45. ncbi Recombinant inbred and congenic strains of the rat for genetic analysis of limb morphogenesis
    V Kren
    Department of Biology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 42:159-66. 1996
    ..5 to 0.6). The verification of all these findings is in progress by means of double congenic strains which, in addition to the Lx gene, carry differential chromosome segments with putative modifiers...
  46. ncbi Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages
    A Kurdowska
    Department of Biochemistry, University of Texas Health Center at Tyler, 75708, USA
    Cytokine 12:1046-53. 2000
    ..The study shows an important clearance mechanism for IL-8 in the lung...
  47. ncbi Common polymorphisms in LRP and A2M do not affect genetic risk for Alzheimer disease in Northern Ireland
    S P McIlroy
    Department of Geriatric Medicine, The Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Am J Med Genet 105:502-6. 2001
    ..The results from this study indicate that polymorphisms in LRP and A2M are not associated with increased risk for AD in Northern Ireland...
  48. ncbi Differential expression of mRNA coding for the alpha-2-macroglobulin family and the LRP receptor system in C57BL/6J and C3H/HeJ male mice
    M N Correia Soeiro
    Departamento de Ultra estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
    Cell Struct Funct 26:161-7. 2001
    ....
  49. ncbi Carbon dioxide pneumoperitoneum alters acute-phase response induced by lipopolysaccharide
    C Are
    Department of Surgery, The Johns Hopkins Medical Institutions, Blalock 665, 600 North Wolfe Street, Baltimore, MD 21205, USA
    Surg Endosc 16:1464-7. 2002
    ..In a rat model, we investigated whether CO2 pneumoperitoneum alters the inflammatory response induced by bacterial lipopolysaccharide (LPS)...
  50. ncbi Pharmacogenomics in Alzheimer's disease
    Ramon Cacabelos
    EuroEspes Biomedical Research Center, Institute for CNS Disorders, 15166 Bergondo, La Coruna, Spain
    Mini Rev Med Chem 2:59-84. 2002
    ..Furthermore, the pharmacogenomics of AD may contribute in the future to optimise drug development and therapeutics, increasing efficacy and safety, and reducing side-effects and unnecessary costs...
  51. ncbi Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta
    Sanja Arandjelovic
    Department of Biochemistry and Molecular Genetics, Box 800214, Charlottesville, Virginia 22908, USA
    Biochemistry 42:6121-7. 2003
    ..The same peptides also inhibited the activity of TGF-beta1 in endothelial cell proliferation assays. These results demonstrate that alpha(2)M-derived peptides target the receptor-binding sequence in TGF-beta...
  52. ncbi Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Am J Med Genet B Neuropsychiatr Genet 126:69-73. 2004
    ..We suggest that these regional variations in LRP1 genotype and allele frequencies in AD could be related to the different patterns of association between this polymorphism and the disease in various European studies...
  53. ncbi Familial clustering and genetic risk for dementia in a genetically isolated Dutch population
    K Sleegers
    Department of Epidemiology, Erasmus Medical Cetre, Rotterdam, The Netherlands
    Brain 127:1641-9. 2004
    ..Our data showed a strong familial clustering of various forms of dementia in this isolated Dutch population. A high percentage of late-onset Alzheimer's disease could be explained by APOE*4, but 55% of its origin is still unknown...
  54. ncbi Characterization of a C3-like cDNA in a coral: phylogenetic implications
    Larry J Dishaw
    Department of Biological Sciences, Florida International University, University Park Campus, 11200 SW 8th Street, Miami, FL 33199, USA
    Immunogenetics 57:535-48. 2005
    ..Furthermore, one may speculate that complement-like opsonic reactions were evolving at the earliest stages of metazoan evolution. This calls for a reassessment of the present concepts concerning the origins and evolution of TEPs...
  55. ncbi Candidate genes for late-onset Alzheimer's disease: focus on chromosome 12
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Mech Ageing Dev 127:36-47. 2006
    ..In this article, we focused on the current knowledge of the genetics of familial late-onset and sporadic AD linked to the chromosome 12, and the future search for other candidate genes...
  56. ncbi [Association of the polymorphism in alpha-2 macroglobulin gene with essential tremor and Parkinson's disease]
    Ying Xiao
    Department of Neurology, the General Hospital of Tianjin Medical University, Tianjin 300052, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:84-5. 2006
    ....
  57. ncbi Differential transcription of multiple forms of alpha-2-macroglobulin in carp (Cyprinus carpio) infected with parasites
    Dalia F Onara
    Polish Academy of Sciences, Institute of Ichthyobiology and Aquaculture, Gołysz, 43 520 Chybie, Poland
    Dev Comp Immunol 32:339-47. 2008
    ..multifiliis. A2M3 was the only a2M isoform with a highly upregulated transcription during infection, suggesting that this particular isoform is of foremost biological importance...
  58. ncbi Novel serum biomarker candidates for liver fibrosis in hepatitis C patients
    Bevin Gangadharan
    Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Clin Chem 53:1792-9. 2007
    ..Liver biopsy is currently the gold standard for assessing liver fibrosis, and no reliable noninvasive diagnostic approach is available. Therefore a suitable serologic biomarker of liver fibrosis is urgently needed...
  59. ncbi Zinc dyshomeostasis, ageing and neurodegeneration: implications of A2M and inflammatory gene polymorphisms
    Eugenio Mocchegiani
    Immunology Center, Section Nutrition, Immunity and Ageing, Research Department, Italian National Research Centres on Ageing, Ancona, Italy
    J Alzheimers Dis 12:101-9. 2007
    ..The role played by MT and A2M is reported in ageing and Alzheimer's disease and on some polymorphisms of A2M and inflammatory genes (cytokines and their receptors) because some of them may be affected by zinc, via MT homeostasis...
  60. ncbi Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism
    Ryan B Anderson
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Leukoc Biol 83:381-92. 2008
    ..CpG ODN bound to alpha 2M* are also protected from degradation by nucleases. This novel targeting technology may improve CpG ODN-based therapeutics by increasing efficacy at reduced doses, thus reducing side-effects and cost...
  61. doi Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, Institut de Genetique Humaine IGH, UPR CNRS1142, Montpellier, France
    Methods Mol Biol 882:635-80. 2012
    ..Knowledge of allotypes is important in antibody engineering and humanization of monoclonal antibodies to improve immunotherapy...
  62. pmc Shrimp alpha-2-macroglobulin prevents the bacterial escape by inhibiting fibrinolysis of blood clots
    Vorrapon Chaikeeratisak
    Department of Biochemistry, Faculty of Science, Center of Excellence for Molecular Biology and Genomics of Shrimp, Chulalongkorn University, Bangkok, Thailand
    PLoS ONE 7:e47384. 2012
    ..harveyi strikingly demonstrated fibrinolysis zones surrounding the bacteria. This study provides the first evidence of the vital role of PmA2M in enhancing bacterial sequestration by protecting blood clots against fibrinolysis...
  63. doi Prognostic polypeptide blood plasma biomarkers of Alzheimer's disease progression
    Hongqian Yang
    Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 40:659-66. 2014
    ..Patients with mild cognitive impairment (MCI) have varying risks of progression to Alzheimer's disease (AD)...
  64. doi Influence of Alpha-2-Macroglobulin 5 bp I/D and Ile1000Val polymorphisms on the susceptibility of Alzheimer's disease: a systematic review and meta-analysis of 52 studies
    Hui Chen
    Department of Neurology, Military General Hospital of Beijing PLA, No 5 Nanmencang, DongSi, Beijing, 100700, China
    Cell Biochem Biophys 70:511-9. 2014
    ..However, due to the heterogeneity in the meta-analysis, the results should be interpreted with caution...
  65. pmc The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator
    Soumyaroop Bhattacharya
    Division of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York Pediatric Molecular and Personalized Medicine Program, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York and
    Am J Physiol Lung Cell Mol Physiol 307:L516-23. 2014
    ..We conclude that a global assessment of gene regulation in the acute neonatal hyperoxia model of BPD-like pathology has identified Ahr as one driver of gene dysregulation...
  66. pmc Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels
    Pia S Petersen
    Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland Center for Metabolism and Obesity Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Am J Physiol Regul Integr Comp Physiol 307:R1458-70. 2014
    ....
  67. doi Association between two α-2-macroglobulin gene polymorphisms and Parkinson's disease: a meta-analysis
    Xingzhi Guo
    a Department of Neurology, Shaanxi Provincial People s Hospital, Xi an, Shaanxi, China
    Int J Neurosci 126:193-8. 2016
    ....
  68. doi Identification, molecular characterization, and gene expression analysis of a CD109 molecule in the Hawaiian bobtail squid Euprymna scolopes
    Natasha Yazzie
    Department of Biology, New Mexico State University, MSC 3AF, PO Box 30001, Las Cruces, NM, USA Electronic address
    Fish Shellfish Immunol 44:342-55. 2015
    ....
  69. pmc Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response
    Donata Federici Canova
    William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    J Control Release 217:284-92. 2015
    ....
  70. doi Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice
    Colby S Shemesh
    1 Department of Pharmacokinetics and Clinical Pharmacology, Ionis Pharmaceuticals, Carlsbad, California
    Nucleic Acid Ther 26:223-35. 2016
    ..Binding to A2M could mediate ASOs to nonproductive compartments, and thus, decreased binding of ASOs to A2M could potentially improve ASO pharmacology. ..
  71. doi Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly
    Sarah Westwood
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Alzheimers Dis 52:561-72. 2016
    ..As in previous studies, acute phase reactants and inflammatory markers dominate this signature. ..
  72. ncbi MULTIFUNCin: A Multifunctional Protein Cue Induces Habitat Selection by, and Predation on, Barnacles
    Graham A Ferrier
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA
    Integr Comp Biol 56:901-913. 2016
    ..As a multifunctional protein cue, MULTIFUNCin provides valuable sensory information, conveys different messages to different species, and drives complex biotic interactions...
  73. pmc Mutations in CPAMD8 Cause a Unique Form of Autosomal-Recessive Anterior Segment Dysgenesis
    Sek Shir Cheong
    Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Am J Hum Genet 99:1338-1352. 2016
    ..Our study delineates a unique form of recessive ASD and defines a role for CPAMD8, a protein of unknown function, in anterior segment development, implying another pathway for the pathogenicity of ASD...
  74. doi Alpha-2-macroglobulin is a modulator of prophenoloxidase system in pacific white shrimp Litopenaeus vannamai
    Sirikwan Ponprateep
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, 114 Sukhumvit 23 Road, Bangkok 10110, Thailand Electronic address
    Fish Shellfish Immunol . 2016
    ..In Vibrio parahaemolyticus AHPND-infected shrimp, the LvA2M activity was suppressed in an early phase of infection while the PO activity was increased. Thus, the proPO-activating system was regulated by the LvA2M...
  75. ncbi [Uniform method for determining the alpha 1-antitrypsin and alpha 2-macroglobulin activity in human blood serum (plasma)]
    V F Nartikova
    Vopr Med Khim 25:494-9. 1979
    ..1 ml) very rapidly and specifically using commercially available substrate; the method might be recommended for routine clinical analysis...
  76. ncbi Kupffer cell stimulation of alpha 2-macroglobulin synthesis in rat hepatocytes and the role of glucocorticoid
    S Kurokawa
    Cell Struct Funct 12:35-42. 1987
    ..The effect of the Kupffer factor and glucocorticoid appears to be regulated in the pretranslational, probably the transcriptional, phase...
  77. pmc Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus
    C C Kan
    Proc Natl Acad Sci U S A 82:2282-6. 1985
    ..The alpha 2M locus was assigned to human chromosome 12 by Southern blot analysis with DNA from a panel of mouse/human somatic cell hybrids, using alpha 2M cDNA as a hybridization probe...
  78. ncbi IgA2 allotypes determined by restriction fragment length polymorphism in IgA deficiency. Re-expression of the silent A2m(2) allotype in the children of IgA-deficient patients
    L Hammarstrom
    Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Sweden
    J Immunogenet 14:197-201. 1987
    ..In all cases the 'silent' IgA2m2 gene was re-expressed, as judged by conventional serological allotyping of serum proteins. These data strongly argue against structural gene deletions or mutations as a cause of IgA deficiency...
  79. ncbi Complex formation between PSA isoenzymes and protease inhibitors
    J Leinonen
    Department of Clinical Chemistry, Helsinki University Central Hospital, Finland
    J Urol 155:1099-103. 1996
    ..We have studied complex formation between the isoenzymes of prostate specific antigen (PSA) and protease inhibitors in vitro...
  80. ncbi Induction and modulation of acute-phase response by protein malnutrition in rats: comparative effect of systemic and localized inflammation on interleukin-6 and acute-phase protein synthesis
    S Lyoumi
    Institut National de la Santé et de la Recherche Médicale et Institut Féderatif de Recherches Multidisciplinaires sur les Peptides, 76233 Bois Guillaume Cedex, France
    J Nutr 128:166-74. 1998
    ..Our results indicate that protein malnutrition by itself induces IL-6 and A2M expression, and that it modulates the APP response to inflammation...
  81. ncbi The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 270:133-6. 1999
    ..In a subset of our larger sample we have also investigated the A2M Val1000lle polymorphism, and again find no evidence for association. We conclude that there is no genetic association between A2M and AD in our case-control sample...
  82. pmc alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis
    L Umans
    Experimental Genetics Group, Center for Human Genetics, Flemish Institute for Biotechnology, Leuven, Belgium
    Am J Pathol 155:983-93. 1999
    ..Mice deficient in MAM and/or MUG thus offer new experimental models for defining in vivo the role of the macroglobulins in pancreatitis and in other normal and pathological processes...
  83. ncbi No association between the alpha2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression
    K Blennow
    Department of Clinical Neuroscience, University of Goteborg, Sahlgren s University Hospital, Molndal, Sweden
    J Neural Transm (Vienna) 107:1065-79. 2000
    ..The lack of an association between the A2M-2 allele and AD in the present study, and the lack of abnormalities in the A2M mRNA or protein suggest that the A2M-2 allele is not associated with AD...
  84. ncbi Trypanosoma cruzi: acute infection affects expression of alpha-2-macroglobulin and A2MR/LRP receptor differently in C3H and C57BL/6 mice
    M de N Soeiro
    Lab Biologia Celular, DUBC, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    Exp Parasitol 96:97-107. 2000
    ..Our present data further contribute to clarifying aspects of the role of A2MR/LRP in a model of acute Chagas' disease in different mouse strains...
  85. ncbi Molecular genetics in IgA nephropathy
    J H Galla
    Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nephron 88:107-12. 2001
    ..Nevertheless, the genetic mechanism(s) of progressive renal failure, whether exclusive to IgAN or to glomerular diseases generally, is of paramount importance...
  86. ncbi Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease
    L Sanchez
    Instituto Reina Sofía Investigación Nefrológica, Hospital Central Asturias, Oviedo, Spain
    Am J Med Genet 105:76-8. 2001
    ..According to our data, the variation at the LRPAP1 gene is associated with the risk of developing LOAD. This is in agreement with the role of the LRPAP1 protein in the amyloidogenic pathway...
  87. ncbi Differential binding properties of human pregnancy zone protein- and alpha2-macroglobulin-proteinase complexes to low-density lipoprotein receptor-related protein
    G A Chiabrando
    Departamento de Bioquimica Clinica, Universidad Nacional de Cordoba, Cordoba, 5000, Argentina
    Arch Biochem Biophys 398:73-8. 2002
    ..The possibility that PZP-proteinase complexes interact with other receptors not available to alpha2-M-proteinase complexes could be considered...
  88. ncbi Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
    Hui Wen Lo
    Cancer Cell 7:575-89. 2005
    ..Our work suggests that the deregulated iNOS/NO pathway may partly contribute to the malignant biology of tumor cells with high levels of nuclear EGFR and STAT3...
  89. ncbi [Alpha 2 macroglobulin immunoturbidimetric assays (DakoCytomation reagents) on Roche Diagnostic analysers (Modular P, Cobas Integra). Application to FibroTest-Actic-Test]
    A Piton
    Federation de Biochimie, Hopital de la Salpetriere, Paris
    Ann Biol Clin (Paris) 63:385-95. 2005
    ..Despite efforts to standardize methods of enzymatic activity measure and proteins measure, we still observe important interlaboratory and intersystem variability...
  90. ncbi Functions of alpha 2 macroglobulins in pregnancy
    Chandrakant Tayade
    Department of Biomedical Sciences, University of Guelph, Guelph, Ont, Canada NIG 2W1
    Mol Cell Endocrinol 245:60-6. 2005
    ..Here, we review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy...
  91. pmc Microarray analysis of androgen-regulated gene expression in testis: the use of the androgen-binding protein (ABP)-transgenic mouse as a model
    Peter Petrusz
    Department of Cell and Developmental Biology and Laboratories for Reproductive Biology, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA
    Reprod Biol Endocrinol 3:70. 2005
    ..We used this model to characterize changes in global gene expression in testis in response to reduced bioavailability of androgens...
  92. ncbi Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice
    Arne Herring
    Institute of Neuropathology, University Hospital, University of Munster, Munster, Germany
    Brain Pathol 18:32-9. 2008
    ..These results suggest a hitherto unknown effect of environmental enrichment counteracting the vascular dysfunction in Alzheimer diseased brain...
  93. ncbi Gene regulation networks related to neural differentiation of hESC
    Jiang F Zhong
    Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Gene Expr 14:23-34. 2007
    ..These findings underscore the importance of network analysis among differentially expressed genes, and should facilitate future study for understanding the gene regulation of hESC pluripotency...
  94. pmc Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype
    Charlotte Gustafsson
    Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    PLoS ONE 3:e2078. 2008
    ..Although uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface, their global gene expression profile is not known...
  95. pmc Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals
    Friederike Flachsbart
    Institute of Clinical Molecular Biology, Christian Albrechts University and University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Eur J Hum Genet 18:59-61. 2010
    ..Consequently, our data support an involvement of the suggested A2M risk haplotype in the pathogenesis of Alzheimer's disease and adds new evidence to the risk-allele depletion hypothesis...
  96. pmc Tracheobronchial protease inhibitors, body surface area burns, and mortality in smoke inhalation
    Margaret Kurzius-Spencer
    University of Arizona Mel and Enid Zuckerman College of Public Health, Community, Environment and Policy Division, Tucson, Arizona 85724, USA
    J Burn Care Res 30:824-31. 2009
    ..Initial SLPI levels predicted subsequent PAP. Increased early A2M in combination with extensive burn predicted early mortality...
  97. doi Evolution of thioester-containing proteins revealed by cloning and characterization of their genes from a cnidarian sea anemone, Haliplanella lineate
    Naoko T Fujito
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo, Japan
    Dev Comp Immunol 34:775-84. 2010
    ..These results suggest that gene duplication and subsequent functional differentiation among C3, A2M and CD109 were very ancient events predating the divergence of the cnidaria and bilateria...
  98. doi Evolution of the thioester-containing proteins (TEPs) of the arthropoda, revealed by molecular cloning of TEP genes from a spider, Hasarius adansoni
    Reo Sekiguchi
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    Dev Comp Immunol 36:483-9. 2012
    ..These results suggest that the common ancestor of the Arthropoda possessed at least three TEP genes, C3, A2M and iTEP and that they were lost differentially in the Crustacean and Hexapodan lineages...
  99. pmc Identification of the nephropathy-susceptibility locus HIVAN4
    Sindhuri Prakash
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Am Soc Nephrol 22:1497-504. 2011
    ..In summary, these data identify HIVAN4 as a major quantitative trait locus for nephropathy and a transregulator of Nphs2. Furthermore, similar selective breeding strategies may help identify further susceptibility loci...
  100. doi Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C
    Seung Ha Park
    Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea
    Clin Biochem 44:1396-9. 2011
    ..Whether new biomarkers contribute significantly to the existing, simple noninvasive test (comprising of routine laboratory parameters such as the AST to platelet ratio index (APRI)) for predicting liver fibrosis remains unknown...

Research Grants19

  1. LRP AND ALZHEIMER'S DISEASE
    Bradley T Hyman; Fiscal Year: 2011
    ..Description, ..
  2. GENETIC EPIDEMIOLOGY OF ALZHEIMER'S DISEASE IN TWINS
    Brenda Plassman; Fiscal Year: 2003
    ..A population-based twin design remains the ideal approach to these sorts of investigations. ..
  3. Alpha2-Macroglobulin-PA Complexes: Novel Anthrax Vaccin*
    SALVATORE PIZZO; Fiscal Year: 2003
    ..These studies will provide a new anthrax vaccine candidate with both improved immunogenicity and decreased reactogenicity. ..
  4. Regulation of Growth Factor Activity by A2 Macroglobulin
    STEVEN GONIAS; Fiscal Year: 2005
    ..abstract_text> ..
  5. REGULATION OF PROTEASE ACTIVITY BY ALPHA 2-MACROGLOBULIN
    Dudley Strickland; Fiscal Year: 1992
    ....
  6. ENVIRONMENTAL MODULATION OF FIBRINOLYSIS INHIBITORS
    STEVEN GONIAS; Fiscal Year: 1992
    ..The goal of this research program is to provide basic research data that will aid in the design of thrombolysis protocols and in the management of patients with hemostasis imbalances...
  7. Mechanisms of beta2-microglubin in Autoimmune Diabetes
    STANLEY NATHENSON; Fiscal Year: 2006
    ..Completion of the proposed Aims should allow identification of the molecular and atomic determinants that result in beta2m-dependent susceptibility or protection against disease. ..
  8. REGULATORY EVENTS IN FIBRINOLYSIS & COAGULATION
    Dudley Strickland; Fiscal Year: 1992
    ....
  9. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
  10. COMPARATIVE DNA SEQUENCE VARIATION IN ALZHEIMER GENES
    John Ely; Fiscal Year: 2002
    ..S. population and reduce the public health burden associated with AD and related neurodegenerative disorders in an aging population. ..
  11. REGULATION OF LRP EXPRESSION AND FUNCTION IN THE CNS
    Isa Hussaini; Fiscal Year: 2001
    ....
  12. ADRENERGIC REGULATION OF HUMAN PROSTATE GROWTH
    Victor Lin; Fiscal Year: 2002
    ....
  13. ASSORTMENT AND TRANSMISSION OF ALCOHOL AND TOBACCO USE
    Chandra Reynolds; Fiscal Year: 2001
    ..abstract_text> ..
  14. MTOPS Prostate Samples Analysis Consortium
    Victor Lin; Fiscal Year: 2004
    ....
  15. BIOMARKERS FOR DIAGNOSIS & MANAGEMENT OF PROSTATE CANCER
    Kailash Chadha; Fiscal Year: 2007
    ..New biomarkers that will have clinical impact and will facilitate to maximize the use of current therapies and to evaluate the future novel, potentially more effective therapies are needed. [unreadable] [unreadable]..
  16. Latent Growth Curve Paths to Longevity: The Terman Study
    Chandra Reynolds; Fiscal Year: 2008
    ..abstract_text> ..
  17. Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease risk
    Chandra A Reynolds; Fiscal Year: 2010
    ....
  18. Genetic Epidemiology of Multiple Sclerosis
    Jonathan L Haines; Fiscal Year: 2010
    ..We will take advantage of our unique large multiplex family dataset to sequence MS cases most likely to carry rare variants of strong effect. ..