APOL1

Summary

Gene Symbol: APOL1
Description: apolipoprotein L1
Alias: APO-L, APOL, APOL-I, FSGS4, apolipoprotein L1, apolipoprotein L 1, apolipoprotein L1-B3
Species: human

Top Publications

  1. pmc Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 104:4118-23. 2007
  2. doi Mutual self-defence: the trypanolytic factor story
    Etienne Pays
    Laboratory of Molecular Parasitology, Universite Libre de Bruxelles, Gosselies, Belgium
    Microbes Infect 10:985-9. 2008
  3. pmc Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor
    Rudo Kieft
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 107:16137-41. 2010
  4. ncbi Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L
    P N Duchateau
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    J Biol Chem 272:25576-82. 1997
  5. ncbi Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene
    P N Duchateau
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    J Lipid Res 42:620-30. 2001
  6. ncbi The human apolipoprotein L gene cluster: identification, classification, and sites of distribution
    N M Page
    School of Animal and Microbial Sciences, The University of Reading, Reading, RG6 6AJ, United Kingdom sasnpagereading ac uk
    Genomics 74:71-8. 2001
  7. ncbi The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue
    Houshang Monajemi
    Department of Biochemistry of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 1105 AZ
    Genomics 79:539-46. 2002
  8. ncbi Apolipoprotein L-I is the trypanosome lytic factor of human serum
    Luc Vanhamme
    Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Nature 422:83-7. 2003
  9. ncbi Characterization of primate trypanosome lytic factors
    Elena B Lugli
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341, East 25th Street, New York, NY 10010, USA
    Mol Biochem Parasitol 138:9-20. 2004
  10. ncbi Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes
    David Perez-Morga
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 309:469-72. 2005

Research Grants

  1. Stephen L Hajduk; Fiscal Year: 2014
  2. BARRY IRA FREEDMAN; Fiscal Year: 2015
  3. Teepu Siddique; Fiscal Year: 2016
  4. Carol R Horowitz; Fiscal Year: 2016
  5. Martin R Pollak; Fiscal Year: 2016
  6. Judith T Blaine; Fiscal Year: 2014
  7. ADIPOSE BIOLOGY AND AV FISTULA FAILURE
    CHRISTINE REBECCA MAURO; Fiscal Year: 2013
  8. Martin R Pollak; Fiscal Year: 2016
  9. Martin R Pollak; Fiscal Year: 2016
  10. Role of APOL1 in HIVAN pathogenesis
    Waldemar Popik; Fiscal Year: 2013

Scientific Experts

Detail Information

Publications155 found, 100 shown here

  1. pmc Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 104:4118-23. 2007
    Apolipoprotein L-I (apoL-I) is a human high-density lipoprotein (HDL) component able to kill Trypanosoma brucei brucei by forming anion-selective pores in the lysosomal membrane of the parasite...
  2. doi Mutual self-defence: the trypanolytic factor story
    Etienne Pays
    Laboratory of Molecular Parasitology, Universite Libre de Bruxelles, Gosselies, Belgium
    Microbes Infect 10:985-9. 2008
    ..environment, great African apes and humans have acquired a new member of the apolipoprotein-L family, termed apoL1. This protein is the only one of the family to be secreted in the blood, where it binds to a subset of HDL ..
  3. pmc Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor
    Rudo Kieft
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 107:16137-41. 2010
    ..We propose that the combination of coding sequence mutations and decreased expression of TbgHpHbR directly contribute to parasite evasion of human innate immunity and infectivity of group 1 T. b. gambiense...
  4. ncbi Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L
    P N Duchateau
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    J Biol Chem 272:25576-82. 1997
    ..123 < d < 1.21 g/ml. Free apoL was not detected in plasma...
  5. ncbi Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene
    P N Duchateau
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    J Lipid Res 42:620-30. 2001
    Previously we identified and cloned the cDNA for a new protein, apolipoprotein L (apoL), present in plasma and mainly associated with large high density lipoprotein particles...
  6. ncbi The human apolipoprotein L gene cluster: identification, classification, and sites of distribution
    N M Page
    School of Animal and Microbial Sciences, The University of Reading, Reading, RG6 6AJ, United Kingdom sasnpagereading ac uk
    Genomics 74:71-8. 2001
    We report the cloning of a new gene family encoding six apolipoprotein L (apoL-I to -VI) proteins. The genes were identified as a cluster spanning a region of 619 kb on chromosome 22...
  7. ncbi The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue
    Houshang Monajemi
    Department of Biochemistry of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 1105 AZ
    Genomics 79:539-46. 2002
    We previously isolated APOL3 (CG12-1) cDNA and now describe the isolation of APOL1 and APOL2 cDNA from an activated endothelial cell cDNA library and show their endothelialspecific expression in human vascular tissue...
  8. ncbi Apolipoprotein L-I is the trypanosome lytic factor of human serum
    Luc Vanhamme
    Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Nature 422:83-7. 2003
    ..interacts strongly with a carboxy-terminal alpha-helix of the human-specific serum protein apolipoprotein L-I (apoL-I)...
  9. ncbi Characterization of primate trypanosome lytic factors
    Elena B Lugli
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341, East 25th Street, New York, NY 10010, USA
    Mol Biochem Parasitol 138:9-20. 2004
    ..We describe here previously unidentified components of highly purified human TLF1: apolipoprotein L-I (apoL-I), human cathelicidin antimicrobial peptide 18 (hCAP18) and glycosylphosphatidylinositol-specific phospholipase D (..
  10. ncbi Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes
    David Perez-Morga
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 309:469-72. 2005
    ..In Trypanosoma brucei, apolipoprotein L-I was targeted to the lysosomal membrane and triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed...
  11. ncbi Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    N Engl J Med 355:2752-6. 2006
    Humans have innate immunity against Trypanosoma brucei brucei that is known to involve apolipoprotein L-I (APOL1). Recently, a case of T. evansi infection in a human was identified in India...
  12. pmc Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death
    Guanghua Wan
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Biol Chem 283:21540-9. 2008
    ..Here we report the cloning and characterization of a novel Bcl-2 homology domain 3 (BH3)-only protein, apolipoprotein L1 (apoL1), that, when overexpressed and accumulated intracellularly, induces AuCD in cells as characterized by ..
  13. pmc ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death
    Siqin Zhaorigetu
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, School of Medicine, Albuquerque, New Mexico 87131 0001, USA
    Autophagy 4:1079-82. 2008
    We recently reported the identification and characterization of a novel BH3-only pro-death protein, apolipoprotein L1 (ApoL1), that, when overexpressed, induces autophagic cell death (ACD) in a variety of cells, including those ..
  14. pmc Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 128:345-50. 2010
    ..Genomes Project to identify two western African-specific missense mutations (S342G and I384M) in the neighboring APOL1 gene, and demonstrate that these are more strongly associated with ESKD than previously reported MYH9 variants...
  15. pmc Association of trypanolytic ApoL1 variants with kidney disease in African Americans
    Giulio Genovese
    Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 329:841-5. 2010
    ..end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22 {FSGS odds ratio = 10.5 [95% confidence interval (CI) 6.0 to 18.4]; H-ESKD odds ratio = 7...
  16. pmc A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9
    Giulio Genovese
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 78:698-704. 2010
    ..comparison of African Americans found variants within a 60 kb region of chromosome 22 containing part of the APOL1 and MYH9 genes associated with increased risk of FSGS...
  17. pmc The APOL1 gene and allograft survival after kidney transplantation
    A M Reeves-Daniel
    Department of Internal Medicine, Section on Nephrology, Winston Salem, North Carolina, USA
    Am J Transplant 11:1025-30. 2011
    Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with nephropathy in African Americans (AAs). The effect of transplanting kidneys from AA donors with two APOL1 nephropathy risk variants is unknown...
  18. pmc Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Genet 7:e1002150. 2011
    Single nucleotide polymorphisms (SNPs) in MYH9 and APOL1 on chromosome 22 (c22) are powerfully associated with non-diabetic end-stage renal disease (ESRD) in African Americans (AAs)...
  19. pmc MYH9 and APOL1 are both associated with sickle cell disease nephropathy
    Allison E Ashley-Koch
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA allison ashleykoch duke edu
    Br J Haematol 155:386-94. 2011
    ..The myosin, heavy chain 9, non-muscle (MYH9) and apolipoprotein L1 (APOL1) genes have been associated with risk for focal segmental glomerulosclerosis and end-stage renal ..
  20. pmc Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 26:3805-10. 2011
    Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with non-diabetic nephropathy in African Americans. ApoL1 proteins associate with high-density lipoprotein (HDL) particles in the circulation...
  21. pmc APOL1 localization in normal kidney and nondiabetic kidney disease
    Sethu M Madhavan
    Department of Medicine and the Rammel kamp Center for Education and Research, Metro Health System Campus, Cleveland, Ohio, USA
    J Am Soc Nephrol 22:2119-28. 2011
    In patients of African ancestry, genetic variants in APOL1, which encodes apolipoprotein L1, associate with the nondiabetic kidney diseases, focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive ..
  22. pmc APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 22:2129-37. 2011
    Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown...
  23. pmc Population-based risk assessment of APOL1 on renal disease
    David J Friedman
    Renal Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Am Soc Nephrol 22:2098-105. 2011
    Case-control studies suggest that African Americans with genetic variants in both copies of APOL1 have increased risk for hypertension-attributable ESRD and focal segmental glomerulosclerosis...
  24. pmc APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy
    Natalia Papeta
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Am Soc Nephrol 22:1991-6. 2011
    ..initial studies implicated MYH9, more recent analyses localized the strongest association within the neighboring APOL1 gene...
  25. pmc Genetic variation in APOL1 associates with younger age at hemodialysis initiation
    Zahra Kanji
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 22:2091-7. 2011
    African Americans have a markedly higher incidence of ESRD compared with other racial groups. Two variants in the APOL1 gene, to date observed only among individuals of recent African ancestry, associate with increased risk for renal ..
  26. pmc APOL1 risk variants predict histopathology and progression to ESRD in HIV-related kidney disease
    Derek M Fine
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Am Soc Nephrol 23:343-50. 2012
    ..Here, we examined the role of APOL1 risk variants in predicting renal histopathology and progression to ESRD in 98 HIV-infected African Americans with ..
  27. pmc The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival
    B T Lee
    Department of Medicine, Division of Nephrology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:1924-8. 2012
    Apolipoprotein L-1 (APOL1) gene variants are associated with end-stage renal disease in African Americans (AAs). Here we investigate the impact of recipient APOL1 gene distributions on kidney allograft outcomes...
  28. pmc HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics
    Mohamed G Atta
    Department of Medicine, Johns Hopkins Medical Center, Baltimore, MD 21205, USA
    Kidney Int 82:338-43. 2012
    ..kidney disease in African Americans and two independent sequence variants in the APOL1 gene, encoding apolipoprotein L1. In this study we determined the frequency of APOL1 risk variants in patients with biopsy-proven HIV-..
  29. pmc Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 82:805-11. 2012
    ..aggregation of non-diabetic end-stage renal disease (ESRD) is found in African Americans and variants in the apolipoprotein L1 gene (APOL1) contribute to this risk...
  30. pmc Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans
    Michael S Lipkowitz
    Division of Nephrology and Hypertension, Department of Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Kidney Int 83:114-20. 2013
    ..To better understand this, coding variants in the apolipoprotein L1 (APOL1) and the nonmuscle myosin heavy chain 9 (MYH9) genes were evaluated for an association with ..
  31. doi APOL1 variants and kidney disease in people of recent African ancestry
    Giulio Genovese
    Stanley Center, Broad Institute, Cambridge, MA 02142, USA
    Nat Rev Nephrol 9:240-4. 2013
    Coding variants within the APOL1 gene have been associated with kidney disease, explaining an association that was previously attributed to variants within the neighbouring MYH9 gene...
  32. pmc Apolipoprotein L1 risk variants associate with systemic lupus erythematosus-associated collapsing glomerulopathy
    Christopher P Larsen
    NephroPath, 10810 Executive Center Drive, Suite 100, Little Rock, AR 72211, USA
    J Am Soc Nephrol 24:722-5. 2013
    ..The presence of APOL1 risk alleles associates with HIV-associated collapsing glomerulopathy, but it is unknown whether these risk ..
  33. ncbi Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor
    Toya Nath Baral
    Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    Nat Med 12:580-4. 2006
    ..Normal human serum (NHS) contains apolipoprotein L-I (apoL-I), which lyses African trypanosomes except resistant forms such as Trypanosoma brucei rhodesiense. T. b...
  34. doi The identification of apolipoprotein genes in rare minnow (Gobiocypris rarus) and their expression following perfluorooctanoic acid exposure
    Xuemei Fang
    Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China
    Comp Biochem Physiol C Toxicol Pharmacol 151:152-9. 2010
    ..Partial cDNA sequences encoding ApoA-IV, ApoE, ApoM, ApoL, and ApoO, and full-length cDNA sequences encoding ApoA-I were cloned from rare minnow (Gobiocypris rarus)...
  35. ncbi The trypanolytic factor of human serum
    Etienne Pays
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine IBMM, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Nat Rev Microbiol 4:477-86. 2006
    ..escapes lysis by human serum led to the identification of an ionic-pore-forming apolipoprotein - known as apolipoprotein L1 - that is associated with high-density-lipoprotein particles in human blood...
  36. ncbi Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein
    Marianne Jensby Nielsen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Blood 108:2846-9. 2006
    Haptoglobin-related protein (Hpr) is a primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL) particles shown to be a part of the innate immune defense...
  37. ncbi Covalent flavinylation of L-aspartate oxidase from Escherichia coli using N6-(6-carboxyhexyl)-FAD succinimidoester
    A Negri
    Istituto di Fisioilogia Veterinaria e Biochimica, Universita di Milano, Milan, Italy
    J Protein Chem 18:671-6. 1999
    ....
  38. ncbi The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis
    A J Infante
    Department of Pediatrics, University of Texas Health Science Center at San Antonio 78284 7810, USA
    J Pediatr 133:629-33. 1998
    ....
  39. pmc Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model
    Maria Pilar Molina-Portela
    Department of Medical Parasitology, New York University Langone Medical Center School of Medicine, New York, NY 10010, USA
    J Exp Med 205:1721-8. 2008
    ..The proteins apolipoprotein (apo) A-I, apoL-I, and haptoglobin-related protein, which are involved in TLF structure and function, were expressed through the ..
  40. doi Testing the antagonistic pleiotropy model of schizophrenia susceptibility by analysis of DAOA, PPP1R1B, and APOL1 genes
    Noa Carrera
    Fundacion Publica Galega de Medicina Xenomica, Santiago de Compostela, Spain
    Psychiatry Res 179:126-9. 2010
    ..Recent work on DAOA, PPP1R1B, and APOL1 suggests that these genes present common alleles associated to increase risk of schizophrenia but conferring an ..
  41. doi The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 21:1422-6. 2010
    ..Statistically stronger associations were detected between two independent sequence variants in the Apolipoprotein L1 gene (APOL1) and nondiabetic nephropathy in African Americans, with odds ratios of 10...
  42. pmc Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22
    Michael L Mimmack
    Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 99:4680-5. 2002
    ..using prefrontal cortex tissue from 10 schizophrenia and 10 control brains revealed robust up-regulation of apolipoprotein L1 (apo L1) by 2.6-fold...
  43. ncbi Solubilization of V-ATPase transmembrane peptides by amphipol A8-35
    Afonso M S Duarte
    Laboratory of Biophysics, Wageningen University, The Netherlands
    J Pept Sci 14:389-93. 2008
    ..These observations are discussed in the context of APol physical-chemical properties and transmembrane peptide structural propensity.
  44. ncbi Antennal SNMPs (sensory neuron membrane proteins) of Lepidoptera define a unique family of invertebrate CD36-like proteins
    M E Rogers
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    J Neurobiol 49:47-61. 2001
    SNMP1-Apol is an antennal-specific protein of the wild silk moth Antheraea polyphemus; the protein is abundantly expressed and localized to the receptor membranes of sex-pheromone specific olfactory sensory neurons (OSNs)...
  45. ncbi Amine-assisted facetted etching of CdSe nanocrystals
    Rongfu Li
    Nanomaterials Optoelectronics Laboratory, Polymer Program, Department of Chemistry, Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, USA
    J Am Chem Soc 127:2524-32. 2005
    The treatment of CdSe nanocrystals (NCs) in a 3-amino-1-propanol (APOL)/water (v/v = 10:1) mixture at 80 degrees C in the presence of O(2) causes them to undergo a slow chemical etching process, as evidenced by spectroscopic and ..
  46. ncbi Human genome-wide screen of haplotype-like blocks of reduced diversity
    Javier Costas
    Centro Nacional de Genotipado, Fundacion Publica Galega de Medicina Xenomica, Hospital Clinico Universitario, Universidade de Santiago de Compostela, E15706, Santiago de Compostela, Spain
    Gene 349:219-25. 2005
    ..for targets of natural selection, such as those blocks containing a cluster of bitter taste receptors or the apolipoprotein L1. In addition, several genes putatively involved in susceptibility to common diseases are included in these ..
  47. ncbi Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes
    April M Shiflett
    Josephine Bay Paul Center, Global Infectious Disease Program, Marine Biological Laboratory, Woods Hole, Massachussetts 02543, USA
    J Biol Chem 280:32578-85. 2005
    ..Here we show that native human HDLs containing haptoglobin-related protein (Hpr), apolipoprotein L-I (apoL-I) and apolipoprotein A-I (apoA-I) are the principle antimicrobial molecules providing protection from trypanosome ..
  48. ncbi Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines
    Ying zhe Fan
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 73000, PR China
    Peptides 27:2165-73. 2006
    ..Moreover, the up-regulation of Fas/Apol (CD95) and decrease in bcl-2 anti-apoptotic gene expression were observed in apoptotic cells...
  49. pmc Association study of apolipoprotein L-I Lys166Glu and Ile244Met gene variants with obesity in Chinese subjects
    Yi Huang
    Laboratory of Genetic Disease and Perinatal Medicine, West China Second University Hospital, Sichuan University, Chengdu, PR China
    Genet Test Mol Biomarkers 16:514-8. 2012
    b>ApoL-I is a newly found component of high-density lipoprotein, and has a potential role in lipid metabolism...
  50. pmc Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol
    Philip A I Guthrie
    Bristol Genetic Epidemiology Laboratory BGEL, MRC Centre for Causal Analyses in Translational Epidemiology MRC CAiTE, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Clifton BS8 2BN, UK
    Gene 499:8-13. 2012
    ....
  51. doi Collapsing glomerulopathy associated lupus in a black female with homozygous APOL1 mutation
    T Kofman
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service d Anatomopathologie, Paris, France
    Lupus 21:1459-62. 2012
    ..to HIV associated nephropathy (HIVAN) has been shown in Afro-Americans: MYH9 polymorhism in 2008 and then APOL1 variants (G1 and G2 alleles) in 2010 were shown to be strongly associated with HIVAN...
  52. pmc Epistatic role of the MYH9/APOL1 region on familial hematuria genes
    Konstantinos Voskarides
    Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
    PLoS ONE 8:e57925. 2013
    ..About 50% of patients develop late proteinuria and chronic kidney disease (CKD). We hypothesized that MYH9/APOL1, two closely linked genes associated with CKD, may be associated with adverse progression in FH...
  53. pmc End-stage renal disease in African Americans with lupus nephritis is associated with APOL1
    Barry I Freedman
    Wake Forest School of Medicine, Winston Salem, North Carolina
    Arthritis Rheumatol 66:390-6. 2014
    ..This study was undertaken to investigate the hypothesis that the apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in African Americans and rare in European Americans, ..
  54. pmc Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei
    Sam Alsford
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Pathog 10:e1004130. 2014
    ..b. brucei exquisitely sensitive to lytic factors in human serum, and indicate that CATL, an important potential drug target, has the capacity to resist these factors. ..
  55. pmc Long-term stability of a vaccine formulated with the amphipol-trapped major outer membrane protein from Chlamydia trachomatis
    H Eric Feinstein
    Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA
    J Membr Biol 247:1053-65. 2014
    ..Previously, we showed that APols maintain nMOMP secondary structure and that nMOMP/APol vaccine formulations elicit better protection than formulations using either recombinant or nMOMP solubilized in Z3-..
  56. doi Solution behavior and crystallization of cytochrome bc₁ in the presence of amphipols
    Delphine Charvolin
    UMR 7099, Centre National de la Recherche Scientifique Université Paris 7, Institut de Biologie Physico Chimique, FRC 550, 13, rue Pierre et Marie Curie, 75005, Paris, France
    J Membr Biol 247:981-96. 2014
    ..Membrane protein/APol complexes have proven, however, difficult to crystallize...
  57. pmc APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes
    Barry I Freedman
    1 Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA 2 Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, North Carolina, USA 3 Center for Diabetes Research, Wake Forest School of Medicine, Winston Salem, North Carolina, USA 4 Center for Public Health Genomics, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Kidney Int 87:176-81. 2015
    Albuminuria and reduced estimated glomerular filtration rate (eGFR) associate with two apolipoprotein L1 gene (APOL1) variants in nondiabetic African Americans (AAs)...
  58. pmc Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1
    Brendan Nichols
    1 Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA 2 Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 87:332-42. 2015
    b>Apolipoprotein L1 (APOL1) risk variants greatly elevate the risk of kidney disease in African Americans...
  59. doi Detecting recent positive selection with high accuracy and reliability by conditional coalescent tree
    Minxian Wang
    Department of Computational Regulatory Genomics, CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China Key Laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
    Mol Biol Evol 31:3068-80. 2014
    ..of four well-known positive selected genes were all successfully localized by our method, such as ADH1B, MCM6, APOL1, and HBB...
  60. doi HDL in infectious diseases and sepsis
    Angela Pirillo
    SISA Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Italy
    Handb Exp Pharmacol 224:483-508. 2015
    ..HDLs are emerging also as a relevant player during parasitic infections, and a specific component of HDL, namely, apoL-1, confers innate immunity against trypanosome by favoring lysosomal swelling which kills the parasite...
  61. pmc Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial
    Jeffrey B Kopp
    Kidney Disease Section
    J Am Soc Nephrol 26:1443-8. 2015
    Genetic variants in apolipoprotein L1 (APOL1) confer risk for kidney disease. We sought to better define the phenotype of APOL1-associated nephropathy...
  62. pmc APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Nephrol Dial Transplant 31:602-8. 2016
    Two independent coding variants in the apolipoprotein L1 gene (APOL1), G1 and G2, strongly associate with nephropathy in African Americans; associations with cardiovascular disease are more controversial...
  63. doi Lipoprotein profiles in human heterozygote carriers of a functional mutation P297S in scavenger receptor class B1
    Stefan A Ljunggren
    Occupational and Environmental Medicine Center, and Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden Electronic address
    Biochim Biophys Acta 1851:1587-95. 2015
    ..Protein analyses showed a significant enrichment of apoE in LDL/VLDL and of apoL-1 in HDL from heterozygotes compared to controls...
  64. pmc Analytical Validation of a Personalized Medicine APOL1 Genotyping Assay for Nondiabetic Chronic Kidney Disease Risk Assessment
    Jinglan Zhang
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York Electronic address
    J Mol Diagn 18:260-6. 2016
    ..Notably, two APOL1 alleles, termed G1 [c.(1072A>G; 1200T>G)] and G2 (c...
  65. pmc APOL1 renal-risk genotypes associate with longer hemodialysis survival in prevalent nondiabetic African American patients with end-stage renal disease
    Lijun Ma
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA Center for Public Health Genomics, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Kidney Int 90:389-95. 2016
    ..Renal-risk variants in the apolipoprotein L1 gene (APOL1), associated with nondiabetic nephropathy and less subclinical atherosclerosis, may contribute ..
  66. pmc Impact of APOL1 polymorphism and IL-1β priming in the entry and persistence of HIV-1 in human podocytes
    Joanna Mikulak
    Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Retrovirology 13:63. 2016
    ..African ancestry with untreated HIV-1 infection and carrying the G1 or G2 kidney disease risk variants (Vs) at the APOL1 gene have a tenfold higher risk of developing HIV-associated nephropathy (HIVAN) compared to those with the non-..
  67. pmc African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos
    Holly J Kramer
    Department of Public Health Sciences and Medicine, and Division of Nephrology and Hypertension, Loyola University Chicago, Maywood, Illinois
    J Am Soc Nephrol . 2016
    ..We examined the association of CKD measures with African ancestry-specific APOL1 alleles that were directly genotyped and sickle cell trait (hemoglobin subunit β gene [HBB] variant) on the basis ..
  68. pmc APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes
    Etty Kruzel-Davila
    Department of Nephrology, Rambam Health Care Campus, Haifa, Israel Departments of
    J Am Soc Nephrol . 2016
    b>APOL1 harbors C-terminal sequence variants (G1 and G2), which account for much of the increased risk for kidney disease in sub-Saharan African ancestry populations...
  69. doi Integrating APOL-1 Gene Variants Into Renal Transplantation: Considerations Arising From the American Society of Transplantation Expert Conference
    Kenneth A Newell
    Emory University School of Medicine, Atlanta, Georgia
    Am J Transplant . 2016
    ..Thirteen percent of individuals of African Ancestry express two variant copies of the gene encoding Apolipoprotein 1 (APOL-1) that has been associated with an increased risk of ESRD in the general population...
  70. pmc Haptoglobin (HP) and Haptoglobin-related protein (HPR) copy number variation, natural selection, and trypanosomiasis
    Robert J Hardwick
    Department of Genetics, University of Leicester, Leicester, UK
    Hum Genet 133:69-83. 2014
    ..protein (coded by the HPR gene) forms part of the trypanolytic factor TLF-1, together with apolipoprotein L1 (ApoL1)...
  71. pmc Serum resistance-associated protein blocks lysosomal targeting of trypanosome lytic factor in Trypanosoma brucei
    Monika W Oli
    Global Infectious Disease Program, Josephine Bay Paul Center, Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    Eukaryot Cell 5:132-9. 2006
    ..subfraction of human high-density lipoprotein (HDL) containing apolipoprotein A-I (apoA-I), apolipoprotein L-I (apoL-I), and haptoglobin-related protein (Hpr) provides this innate protection against T. b. brucei infection...
  72. ncbi The function of apolipoproteins L
    B Vanhollebeke
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, 6041 Gosselies, Belgium
    Cell Mol Life Sci 63:1937-44. 2006
    The function of the proteins of the apolipoprotein L (apoL) family is largely unknown...
  73. pmc APOL1 variants associate with increased risk of CKD among African Americans
    Meredith C Foster
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 24:1484-91. 2013
    Although case-control studies suggest that African Americans with common coding variants in the APOL1 gene are 5-29 times more likely than those individuals without such variants to have focal segmental glomerulosclerosis, HIV-associated ..
  74. doi Mechanism of Trypanosoma brucei gambiense resistance to human serum
    Pierrick Uzureau
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12 rue des Prof Jeener et Brachet, B 6041 Gosselies, Belgium
    Nature 501:430-4. 2013
    ..trypanolytic factors (TLF-1 and -2), which both contain haptoglobin-related protein (HPR) and apolipoprotein LI (APOL1)...
  75. doi Keloids and non-diabetic kidney disease: similarities and the APOL1-MYH9 haplotype as a possible genetic link
    Brett H Keeling
    University of Florida College of Medicine, Gainesville, FL, USA Electronic address
    Med Hypotheses 81:908-10. 2013
    ..MYH9 and APOL1 are in linkage disequilibrium and have both been associated with non-diabetic kidney disease...
  76. pmc APOL1 risk variants, race, and progression of chronic kidney disease
    Afshin Parsa
    The authors affiliations are listed in the Appendix
    N Engl J Med 369:2183-96. 2013
    ..Among patients in the United States with chronic kidney disease, black patients are at increased risk for end-stage renal disease, as compared with white patients...
  77. pmc Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians
    Bamidele O Tayo
    Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, 2160 S First Ave, Maywood, IL, USA
    Int Urol Nephrol 45:485-94. 2013
    A region of chromosome 22 which includes APOL1 and MYH9 genes was recently identified as a risk locus for non-diabetic forms of kidney disease, including idiopathic and HIV-associated focal segmental glomerular sclerosis and kidney ..
  78. doi Amphipol trapping of a functional CYP system
    Tomas Laursen
    Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Biotechnol Appl Biochem 60:119-27. 2013
    ..b>APol surfactants are short polymers composed of a hydrophilic backbone randomly grafted with hydrophobic side chains...
  79. doi High population frequencies of APOL1 risk variants are associated with increased prevalence of non-diabetic chronic kidney disease in the Igbo people from south-eastern Nigeria
    Ifeoma I Ulasi
    Renal Unit, Department of Medicine, College of Medicine, Enugu Campus, Enugu, Nigeria
    Nephron Clin Pract 123:123-8. 2013
    Continental Africa is facing an epidemic of chronic kidney disease (CKD). APOL1 risk variants have been shown to be strongly associated with an increased risk for non-diabetic kidney disease including HIV nephropathy, primary non-..
  80. ncbi Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
    R M Pitti
    Department of Molecular Oncology, Molecular Biology, and Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 396:699-703. 1998
    ..killer cells and it induces apoptosis (programmed cell death) in target cells through the death receptor Fas/Apol/CD95...
  81. ncbi Estrogenic activities of isoflavones and flavones and their structure-activity relationships
    Sun Young Choi
    Food Function Research Group, Korea Food Research Institute, Gyeonggi Do, Republic of Korea
    Planta Med 74:25-32. 2008
    ..with regard to ER alpha shows a positive correlation with MW and AlogP, and a negative correlation with Apol and Area (r2 = 0.89 and q2 = 0.83)...
  82. doi A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 320:677-81. 2008
    ..Thus, in humans the presence of haptoglobin-related protein has diverted the function of the trypanosome haptoglobin-hemoglobin receptor to elicit innate host immunity against the parasite...
  83. pmc C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    Laurence Lecordier
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS Pathog 5:e1000685. 2009
    Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T...
  84. doi Amphipols from A to Z
    J L Popot
    Institut de Biologie Physico Chimique, CNRS Université Paris 7 UMR 7099, Paris, France
    Annu Rev Biophys 40:379-408. 2011
    ..The functionality and ligand-binding properties of APol-trapped MPs are reviewed, and the mechanisms by which APols stabilize MPs are discussed...
  85. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
    ..We tested for association of single nucleotide polymorphisms (SNPs) in MYH9 with T2DM-ESRD in European Americans; additionally, three APOL1 gene variants were evaluated.
  86. pmc Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
    C P Lin
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 13:232-8. 2012
    ..between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample...
  87. doi APOL1 expression is induced by Trypanosoma brucei gambiense infection but is not associated with differential susceptibility to sleeping sickness
    Hamidou Ilboudo
    Centre International de Recherche Développement sur l Elevage en zone Subhumide, 01 BP 454 Bobo Dioulasso 01, Burkina Faso
    Infect Genet Evol 12:1519-23. 2012
    ..Trypanosome lysis was demonstrated to be associated with apolipoprotein L-I (APOL1). Trypanosoma brucei (T. b...
  88. pmc Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics
    Rebecca L Smathers
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 7:e38459. 2012
    ..Thermal stability curves of apo L-FABP was also found to be significantly affected by 4-HNE adduction (ΔTm = 5.44°C, P<0.01)...
  89. doi MALDI-TOF mass spectrometry analysis of amphipol-trapped membrane proteins
    Cherine Bechara
    Université Pierre et Marie Curie UPMC Université Paris 06, Laboratoire des BioMolécules LBM, Paris, France
    Anal Chem 84:6128-35. 2012
    ..APols also protect MPs against denaturation. Here, we have examined the ability of APol-trapped MPs to be analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-..
  90. doi Well-defined critical association concentration and rapid adsorption at the air/water interface of a short amphiphilic polymer, amphipol A8-35: a study by Förster resonance energy transfer and dynamic surface tension measurements
    Fabrice Giusti
    UMR 7099, CNRS Université Paris 7, Institut de Biologie Physico Chimique, 13 rue Pierre et Marie Curie, F 75005 Paris, France
    Langmuir 28:10372-80. 2012
    ..At variance with MP/detergent complexes, MP/APol ones remain stable even at extreme dilutions...
  91. doi APOL1 variants in HIV-associated nephropathy: just one piece of the puzzle
    Thomas Hays
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 82:259-60. 2012
    Considerable attention has been focused on how the APOL1/MYH9 locus determines susceptibility to focal segmental glomerulosclerosis, including HIV-associated nephropathy (HIVAN)...
  92. pmc Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association
    Amy Rebecca Bentley
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 5635, USA
    Int J Nephrol 2012:748984. 2012
    ..the role of an African ancestry-specific nephropathy risk variant, rs73885319, in the gene encoding HDL-associated APOL1. Among AA, an inverse HDLc-eGFR association was observed only with the risk genotype (-0.38 versus 0.001; P = 0...
  93. pmc Multiple loci associated with renal function in African Americans
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA
    PLoS ONE 7:e45112. 2012
    ..We included in our follow-up study two variants in APOL1 associated with end-stage kidney disease discovered by admixture mapping in admixed African Americans...
  94. doi Distinct composition of human fetal HDL attenuates its anti-oxidative capacity
    Ivana Sreckovic
    Department of Obstetrics and Gynecology, Medical University of Graz, Austria
    Biochim Biophys Acta 1831:737-46. 2013
    ..In contrast, proteins that were enriched in maternal HDL (apoL, apoF, PON1, apoD, apoCs) have been described almost exclusively in the dense HDL3 fraction and relevant to its ..
  95. doi Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation
    Yao Tian
    Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China
    Neuron 77:311-22. 2013
    ..Using yeast two-hybrid screening, we identify that Neurexin interacts with apolipoprotein I (ApoL I), a product generated by cleavage of retinoid- and fatty acid-binding glycoprotein (RFABG) that functions in ..
  96. pmc A consideration of genetic mechanisms behind the development of hypertension in blacks
    Wanzhu Tu
    Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Hypertens Rep 15:108-13. 2013
    ..with a variety of phenotypes consistent with a more active cotransporter in blacks; and (3) the genes for MYH9 and APOL 1, which have been associated with kidney disease in blacks...
  97. ncbi Familial focal segmental glomerulosclerosis (FSGS) in a Nigerian family and exclusion of mutations in NPHS2,WT1 and APOL1
    I C Anochie
    Department of Pediatrics, University of Port Harcourt Teaching Hospital, PMB 6173, Port Harcourt, Rivers State, Nigeria
    West Afr J Med 31:273-6. 2012
    ..Genetic mutations implicated in familial FSGS involving NPHS1, NPHS2, WTI and APOL1 have not been studied in African children living outside America...
  98. pmc Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon
    D Pieniazek
    HIV Retrovirus Diseases Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 4:649-56. 1998
    ..Potential recombinants combining parts of viral regions from different subtypes Aenv/Dpol/Agag, Genv/Apol, and the unclassifiable-subtype(env)/unclassifiable-subtype(pol)/Agag were found in three patients...
  99. ncbi Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects
    P N Duchateau
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Lipid Res 41:1231-6. 2000
    ..In an effort to gain inference as to its as yet unknown function, we studied biological determinants of apoL levels in human plasma...
  100. ncbi Senescence-associated genes in normal human oral keratinocytes
    Mo K Kang
    School of Dentistry and Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Exp Cell Res 287:272-81. 2003
    ..These results indicate that the onset of senescence in NHOK is associated with altered expression of the SA genes, which represent discrete gene groups, independently of the donor variation or culture conditions...

Research Grants29

  1. Stephen L Hajduk; Fiscal Year: 2014
    ..found in all HDLs, and two primate specific proteins, haptoglobin related protein (Hpr) and apolipoprotein L-1 (apoL-1)...
  2. BARRY IRA FREEDMAN; Fiscal Year: 2015
    ..Racial differences in the frequency of Apolipoprotein L1 gene (APOL1) variants are now known to account for these differences...
  3. Teepu Siddique; Fiscal Year: 2016
    ..Further studies of the paraoxonases and apolipoprotein L1 in the plasma indicate that their levels are significantly elevated in SALS patients...
  4. Carol R Horowitz; Fiscal Year: 2016
    ..Recent discoveries demonstrate that testable alleles of the APOL1 locus on chromosome 22 have a major effect on and explain almost all of the excess risk for hypertension-..
  5. Martin R Pollak; Fiscal Year: 2016
    ..Recently, we discovered two coding sequence variants in ApolipoproteinL1 (APOL1) that account for a large proportion of this major health disparity...
  6. Judith T Blaine; Fiscal Year: 2014
    ..of the mechanisms of albumin uptake and disposal in normal podocytes will allow comparison of these mechanisms in APOL1 risk allele podocytes...
  7. ADIPOSE BIOLOGY AND AV FISTULA FAILURE
    CHRISTINE REBECCA MAURO; Fiscal Year: 2013
    ..Polymorphisms associated with the ApoL1 gene on chromosome 22 have been shown to cause kidney failure in African Americans...
  8. Martin R Pollak; Fiscal Year: 2016
    ..We also identified two coding variants in APOL1 that explain the high rate of FSGS and other non-diabetic kidney diseases in African Americans...
  9. Martin R Pollak; Fiscal Year: 2016
    ..Recently we showed that coding sequence variants in the ApolipoproteinL1 (ApoL1) gene, present only in individuals with recent African ancestry, explain a very large proportion of this health ..
  10. Role of APOL1 in HIVAN pathogenesis
    Waldemar Popik; Fiscal Year: 2013
    ..of focal segmentl glomerulosclerosis (FSGS) and HIVAN have led to the discovery of genetic variants of the APOL1 gene that predispose African Americans homozygous for these risk alleles to the development of these nephropathies...
  11. Clinical characterization of the APOL1-associated phenotype
    Ravi Thadhani; Fiscal Year: 2011
    ..Work by our team has shown that the major genetic risk is conferred by variants in the APOL1 gene...
  12. Luis M de la Maza; Fiscal Year: 2014
    ..Our preliminary experiments indicate that candidate vaccines formulated with APol-trapped MOMP are more effective than their detergent-based equivalents...
  13. Pravin C Singhal; Fiscal Year: 2016
    ..Its manifestation requires presence of specific ancestry (APOL1 gene), environmental (HIV infection), and host factors...
  14. Kidney disease mechanisms associated with human genetic variation
    John R Sedor; Fiscal Year: 2012
    ..The recently described APOL1 risk alleles associated with CKD and African Ancestry is one example, where only a portion of genetically-..
  15. Role of High Density Lipoprotein Particles in amyotrophic lateral sclerosis
    Teepu Siddique; Fiscal Year: 2012
    ..Using advanced gene targeting techniques, we will create ApoL1 transgenic model mice to study the effects of over expressing this HDL component...
  16. ApoJ (Clusterin) in Alzheimer's Disease and Aging
    Caleb Finch; Fiscal Year: 2006
    ..New data shows that apoL can activate microglia in vivo and in vitro...
  17. Genetics, Lipids, and Responses to Exercise Training
    Amy Halverstadt; Fiscal Year: 2006
    ..provided by applicant): The proposed study will assess and characterize new genetic variants in LIPH and APOL1 that may relate to plasma lipoprotein lipid levels and their changes with exercise training...
  18. Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial Disease
    Kenneth Jay Mukamal; Fiscal Year: 2010
    ..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
  19. NEWBORN GENETIC SCREENING:FOR WHOSE BENEFIT?
    Lainie Ross; Fiscal Year: 2005
    ..OUTCOMES: The major outcomes will be a series of peer-reviewed articles and a full-length book entitled Newborn Genetic Screening: In whose Interest? For whose Benefit? ..
  20. Heavy Drinking & Coronary Disease: Acute/Chronic Effects
    Kenneth Mukamal; Fiscal Year: 2006
    ..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
  21. Transcriptional regulation in chronic renal disease pathogenesis
    LESLIE BRUGGEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Novel Proapoptotic BH3-only Proteins in Cancer Apoptosis
    Chien An Hu; Fiscal Year: 2009
    ..By transient expression analysis, we showed that ApoL6, ApoL1 and BOMB promoted cell death in p53-null HCT116 cells...
  23. Continuation of the FIND Study
    Barry Freedman; Fiscal Year: 2006
    ..of genes that cause diabetic complications will take us one step closer to finding treatments that may have the potential to slow or prevent the development of these serious complications of diabetes mellitus [unreadable] [unreadable]..
  24. Apolipoprotein-mediated cholesterol efflux
    W Davidson; Fiscal Year: 2008
    ..This understanding will form a basis for new interventions designed to enhance apolipoprotein-mediated cholesterol efflux from cells, particularly those within the atherosclerotic vessel wall. ..
  25. A Renal Epithelial Urea Sensor
    David Cohen; Fiscal Year: 2005
    ..In addition, the sufficiency of these and related signaling elements for urea signaling will be examined in models of heterologous expression. ..
  26. Expression of TRPV1 and variant TRPV1 in the kidney
    David Cohen; Fiscal Year: 2005
    ..In addition, such a reagent might have potential therapeutic utility with respect to this important pathway mediating nociception. ..
  27. The roles of apolipoprotein A-IV structure and lipid affinity in its function
    W Davidson; Fiscal Year: 2009
    ....
  28. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 2001
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..