aryl hydrocarbon receptor

Summary

Gene Symbol: aryl hydrocarbon receptor
Description: aryl hydrocarbon receptor
Alias: bHLHe76, aryl hydrocarbon receptor, AH-receptor, ah receptor, aromatic hydrocarbon receptor, class E basic helix-loop-helix protein 76
Species: human

Top Publications

  1. pmc The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes
    Mark Wormke
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Mol Cell Biol 23:1843-55. 2003
  2. ncbi Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
    Fumiaki Ohtake
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Nature 423:545-50. 2003
  3. ncbi Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest
    A Puga
    Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 275:2943-50. 2000
  4. pmc Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Hum Mol Genet 20:2071-7. 2011
  5. pmc Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes
    Ayelet Ziv-Gal
    Department of Comparative Biosciences, University of Illinois, Urbana, IL 61802, USA
    Am J Obstet Gynecol 207:202.e9-202.e18. 2012
  6. ncbi Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms
    J Smart
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, UK
    Pharmacogenetics 10:11-24. 2000
  7. doi A role of the aryl hydrocarbon receptor in attenuation of colitis
    Keisuke Furumatsu
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Chuo Ku, Kusunoki cho, Kobe, Hyogo 650 0017, Japan
    Dig Dis Sci 56:2532-44. 2011
  8. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
  9. ncbi Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex
    T A Nguyen
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas, 77843 4466, USA
    Arch Biochem Biophys 367:250-7. 1999
  10. ncbi Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas
    Jinghua Tsai Chang
    Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taiwan, ROC
    Clin Cancer Res 13:38-45. 2007

Research Grants

  1. Ah Receptor and Endothelin-Dependent Hypertension
    Mary K Walker; Fiscal Year: 2010
  2. Alvaro Puga; Fiscal Year: 2015
  3. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
  4. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
  5. Circadian Clock Disruption: A Mechanism for Dioxin-induced Metabolic Syndrome
    Shelley A Tischkau; Fiscal Year: 2013
  6. Norbert E Kaminski; Fiscal Year: 2016
  7. SkyScan 1076 In Vivo Micro-Computed Tomography System
    Timothy M Ryan; Fiscal Year: 2010
  8. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2012
  9. Thomas R Sutter; Fiscal Year: 2014
  10. Barbara Platzer; Fiscal Year: 2015

Detail Information

Publications249 found, 100 shown here

  1. pmc The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes
    Mark Wormke
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Mol Cell Biol 23:1843-55. 2003
    2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) ligands suppress 17beta-estradiol (E)-induced responses in the rodent uterus and mammary tumors and in human breast cancer cells...
  2. ncbi Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
    Fumiaki Ohtake
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Nature 423:545-50. 2003
    ....
  3. ncbi Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest
    A Puga
    Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 275:2943-50. 2000
    ..The presence of an LXCXE domain in the dioxin aromatic hydrocarbon receptor (AHR), suggested that the effects of TCDD on cell cycle regulation might be mediated by protein-..
  4. pmc Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Hum Mol Genet 20:2071-7. 2011
    ..4 · 10(-14)) and rs6968865-T near aryl hydrocarbon receptor (AHR) at 7p21 (P = 2.3 · 10(-11)). An effect of ∼0.2 cups a day per allele was observed for both SNPs...
  5. pmc Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes
    Ayelet Ziv-Gal
    Department of Comparative Biosciences, University of Illinois, Urbana, IL 61802, USA
    Am J Obstet Gynecol 207:202.e9-202.e18. 2012
    We sought to determine if genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels.
  6. ncbi Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms
    J Smart
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, UK
    Pharmacogenetics 10:11-24. 2000
    ..variation in levels of induced CYP1A1 activity has been investigated by screening both the CYP1A1 gene and the Ah receptor gene (AhR) for both previously described and novel polymorphisms...
  7. doi A role of the aryl hydrocarbon receptor in attenuation of colitis
    Keisuke Furumatsu
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Chuo Ku, Kusunoki cho, Kobe, Hyogo 650 0017, Japan
    Dig Dis Sci 56:2532-44. 2011
    The aryl hydrocarbon receptor (AhR), which is a member of the basic helix-loop-helix/Per-Arnt-Sim homology superfamily, plays an important role in multiple biological functions, and AhR knockout (AhR KO) animals suffer from a variety of ..
  8. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
    ..No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, EPHX2 in this population...
  9. ncbi Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex
    T A Nguyen
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas, 77843 4466, USA
    Arch Biochem Biophys 367:250-7. 1999
    MCF-7 human breast cancer cells express the aryl hydrocarbon receptor (AhR), and treatment with AhR agonists such as 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) inhibits estrogen receptor (ER)-mediated responses...
  10. ncbi Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas
    Jinghua Tsai Chang
    Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taiwan, ROC
    Clin Cancer Res 13:38-45. 2007
    CYP1B1 and CYP1A1 expression is up-regulated by activation of the aryl hydrocarbon receptor (AhR) through binding of ligands such as cigarette smoke components...
  11. pmc The active form of human aryl hydrocarbon receptor (AHR) repressor lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible factor
    Sibel I Karchner
    Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Mol Cell Biol 29:3465-77. 2009
    The aryl hydrocarbon receptor (AHR) repressor (AHRR) inhibits AHR-mediated transcription and has been associated with reproductive dysfunction and tumorigenesis in humans...
  12. pmc beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor
    Udi Gluschnaider
    Department of Pathology and the Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 5:e9060. 2010
    ..Thus, alternative strategies targeting novel molecular mechanisms are required. beta-TrCP is an E3 ligase that targets various substrates essential for many aspects of tumorigenesis...
  13. ncbi A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Q Ma
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5332, USA
    J Biol Chem 272:8878-84. 1997
    ..and transcriptional regulation, we used a yeast two-hybrid system to identify proteins that interact with the Ah receptor (AhR)...
  14. ncbi AH receptor, ARNT, glucocorticoid receptor, EGF receptor, EGF, TGF alpha, TGF beta 1, TGF beta 2, and TGF beta 3 expression in human embryonic palate, and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    B D Abbott
    Division of Reproductive Toxicology, National Health Effects and Environmental Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Teratology 58:30-43. 1998
    ..growth factor-beta 1 (TGF beta 1), TGF beta 2, TGF beta 3, glucocorticoid receptor (GR), the aryl hydrocarbon receptor (AhR), and the Ah receptor nuclear translocator (ARNT) were localized in gestational days (GD) 49-59 ..
  15. ncbi Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors
    Susan L Woods
    Department of Molecular Biosciences, Center for the Molecular Genetics of Development, Adelaide University, South Australia 5005, Australia
    J Biol Chem 277:10236-43. 2002
    ....
  16. pmc Aryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cells
    Pankaj Dabir
    Department of Molecular Cardiology, Cleveland Clinic, Ohio, USA
    Circ Res 102:1558-65. 2008
    ..A putative binding site for the transcription factor aryl hydrocarbon receptor (AhR) was identified in the glucose-responsive fragment of the promoter of thrombospondin-1, a potent ..
  17. doi Association of aryl hydrocarbon receptor gene polymorphisms and urinary 1-hydroxypyrene in polycyclic aromatic hydrocarbon-exposed workers
    Ping Bin
    National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, PR China
    Cancer Epidemiol Biomarkers Prev 17:1702-8. 2008
    ..In this study, we investigated the association of aryl hydrocarbon receptor (AhR) gene polymorphisms and urinary 1-OHP...
  18. pmc Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    PLoS ONE 4:e5130. 2009
    ..The question is important because of the clinical significance of fascin expression in human carcinomas...
  19. ncbi Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2
    J R Petrulis
    Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 275:37448-53. 2000
    The hepatitis B virus X-associated protein 2 (XAP2) is an immunophilin homolog and core component of the aryl hydrocarbon receptor (AhR). Immunophilins are components of many steroid receptor complexes, serving a largely unknown function...
  20. pmc Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex
    Timothy V Beischlag
    Department of Pathology and Laboratory Medicine, Molecular Biology Institute, and Jonsson Comprehensive Cancer Center, School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Mol Cell Biol 22:4319-33. 2002
    The aryl hydrocarbon receptor complex heterodimeric transcription factor, comprising the basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) ..
  21. ncbi Role of the aryl hydrocarbon receptor in cell cycle regulation
    Alvaro Puga
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, OH 45267 0056, USA
    Chem Biol Interact 141:117-30. 2002
    Traditionally, the aryl hydrocarbon receptor (AHR) is considered to be a ligand-activated receptor and transcription factor responsible for the induction of drug-metabolizing enzymes...
  22. ncbi Polymorphisms in the human AH receptor
    Patricia A Harper
    Division of Clinical Pharmacology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Chem Biol Interact 141:161-87. 2002
    The AH receptor (AHR) mediates toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as well as induction of three cytochrome P450 enzymes and certain Phase II enzymes...
  23. ncbi Ligand-dependent and independent modulation of aryl hydrocarbon receptor localization, degradation, and gene regulation
    Zhijuan Song
    Department of Biology, University of South Florida, Tampa, Florida, USA
    Mol Pharmacol 62:806-16. 2002
    ..Studies were designed to evaluate the relationship between aryl hydrocarbon receptor (AHR) localization, stability, and gene regulation in a defined system where the endogenous AHR protein ..
  24. ncbi Cell density regulates intracellular localization of aryl hydrocarbon receptor
    Togo Ikuta
    Research Institute and Department of Pathology, Saitama Cancer Center, Saitama, 362 0806, Japan
    J Biol Chem 279:19209-16. 2004
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays a role as an intracellular mediator of the xenobiotic signaling pathway...
  25. pmc Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters
    Jason Matthews
    Department of Biosciences at Novum, Karolinska Institutet, Novum 14157, Sweden
    Mol Cell Biol 25:5317-28. 2005
    ..assays, we studied the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated recruitment of the aryl hydrocarbon receptor (AhR) and several co-regulators to the CYP1A1 promoter...
  26. ncbi Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism
    M Diry
    UMR S 490 INSERM, UFR Biomédicale des Saints Pères, Paris, Cedex, France
    Oncogene 25:5570-4. 2006
    ..effects are mimicked by constitutive expression and activation of the intracellular dioxin receptor (aryl hydrocarbon receptor (AhR))...
  27. ncbi Functional interaction of nuclear receptor coactivator 4 with aryl hydrocarbon receptor
    Alexandra Kollara
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
    Biochem Biophys Res Commun 346:526-34. 2006
    b>Aryl hydrocarbon receptor (AhR) transcriptional activity is enhanced by interaction with p160 coactivators. We demonstrate here that NcoA4, a nuclear receptor coactivator, interacts with and amplifies AhR action...
  28. ncbi Role of the aryl hydrocarbon receptor in drug metabolism
    Preeti Ramadoss
    The Pennsylvania State University, Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary Science, University Park, PA 16802, USA
    Expert Opin Drug Metab Toxicol 1:9-21. 2005
    The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that regulates the transcription of certain key enzymes involved in the metabolism of xenobiotic substances including some drugs...
  29. pmc The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates
    Wayne A Fritz
    School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
    Carcinogenesis 29:1077-82. 2008
    Hypoxia-inducible factor-1 alpha (HIF-1alpha) and aryl hydrocarbon receptor nuclear translocator (ARNT) are basic helix-loop-helix/per-arnt-sim (PAS) family transcription factors...
  30. pmc Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells
    Brett D Hollingshead
    Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania, USA
    Cancer Res 68:3609-17. 2008
    ..presented herein show that, in MCF-7 breast and ECC-1 endocervical cancer cells, the stimulation of aryl hydrocarbon receptor (AHR) activity, in combination with IL-1beta or phorbol 12-myristate 13-acetate (PMA) treatment, results ..
  31. pmc The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis
    Jennifer L Marlowe
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Mol Biol Cell 19:3263-71. 2008
    ..These results point to a proproliferative, antiapoptotic function of the Ah receptor that likely plays a role in tumor progression.
  32. doi Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation
    Jurgen Borlak
    Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Str 1, 30625 Hannover, Germany
    Mol Cancer Res 6:1326-36. 2008
    ..past, we reported induction of c-raf gene expression in rat liver cancer on treatment with a mixture of aryl hydrocarbon receptor (AhR) agonists...
  33. pmc Potential therapeutic significance of increased expression of aryl hydrocarbon receptor in human gastric cancer
    Tie Li Peng
    Department of Gastroenterology, the First Affiliated Hospital of Sun Yat Sen University, 58 Zhongshan II Road, Guangzhou, Guangdong Province, China
    World J Gastroenterol 15:1719-29. 2009
    To determine the functional significance of aryl hydrocarbon receptor (AhR) in gastric carcinogenesis, and to explore the possible role of AhR in gastric cancer (GC) treatment.
  34. pmc The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy
    Shu Zhang
    Institute of Biosciences and Technology, Texas A and M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA
    Endocr Relat Cancer 16:835-44. 2009
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and the relatively non-toxic selective aryl hydrocarbon receptor (AhR) modulator 6-methyl-1,3,8-trichlorodibenzo-furan (MCDF) induced CYP1A1-dependent ethoxyresorufin O-deethylase activity and ..
  35. doi Aryl hydrocarbon receptor regulates cell cycle progression in human breast cancer cells via a functional interaction with cyclin-dependent kinase 4
    Melissa A Barhoover
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 77:195-201. 2010
    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with constitutive activities and those induced by xenobiotic ligands, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
  36. pmc Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice
    Dalei Wu
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Arterioscler Thromb Vasc Biol 31:1260-7. 2011
    ..we showed that treatment of macrophages with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to aryl hydrocarbon receptor (AhR)-dependent activation of inflammatory mediators and the formation of cholesterol-laden foam cells...
  37. doi Aryl hydrocarbon receptor protects lung adenocarcinoma cells against cigarette sidestream smoke particulates-induced oxidative stress
    Ya Hsin Cheng
    Graduate Institute of Basic Medical Science, School of Medicine, China Medical University, Taichung 40402, Taiwan, ROC
    Toxicol Appl Pharmacol 259:293-301. 2012
    Environmental cigarette smoke has been suggested to promote lung adenocarcinoma progression through aryl hydrocarbon receptor (AhR)-signaled metabolism...
  38. pmc Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation
    Guofeng Xie
    Division of Gastroenterology and Hepatology, Univ of Maryland School of Medicine, 22 S Greene St, N3W62, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1006-15. 2012
    The aryl hydrocarbon receptor (AhR) mediates many toxic effects of environmental pollutants. AhR also interacts with multiple growth factor-driven signaling pathways...
  39. doi High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq
    Raymond Lo
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Toxicol Sci 130:349-61. 2012
    The aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) activated complex regulates genes in response to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
  40. pmc The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation
    Brenden W Smith
    Section of Hematology and Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Blood 122:376-85. 2013
    The evolutionarily conserved aryl hydrocarbon receptor (AhR) has been studied for its role in environmental chemical-induced toxicity...
  41. pmc Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology
    Peng Hu
    Departments of Ophthalmology, Pathology, and Pharmacology and Cancer Biology, Duke University, Durham, NC 27710
    Proc Natl Acad Sci U S A 110:E4069-78. 2013
    The aryl hydrocarbon receptor (AhR) is a nuclear receptor that regulates xenobiotic metabolism and detoxification...
  42. ncbi Interindividual difference in expression of human Ah receptor and related P450 genes
    S Hayashi
    Department of Biochemistry, Saitama Cancer Center Research Institute, Japan
    Carcinogenesis 15:801-6. 1994
    The genomic clones of human aryl hydrocarbon receptor (Ahr) and Ahr nuclear translocator (Arnt) were isolated, and the structures of exon-intron junctions of these genes were partially determined...
  43. ncbi Polymorphisms of human Ah receptor gene are not involved in lung cancer
    K Kawajiri
    Department of Biochemistry, Saitama Cancer Center Research Institute, Japan
    Pharmacogenetics 5:151-8. 1995
    The Ah receptor (Ahr) is a ligand-dependent transcription factor that positively regulates inducible expression of the CYP1A1 gene...
  44. ncbi Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors
    M Ema
    Department of Chemistry, Faculty of Science, Tohoku University, Sendai, Japan
    J Biol Chem 269:27337-43. 1994
    ....
  45. ncbi Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo
    L A Carver
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin 53706 1599, USA
    J Biol Chem 272:11452-6. 1997
    In an effort to identify regulators of aryl hydrocarbon receptor (AHR) signaling, we have employed the yeast two-hybrid system to screen for human proteins that interact in a ligand-dependent manner with the AHR. After screening 1...
  46. ncbi Expression of the aryl hydrocarbon receptor (AhR) and the aryl hydrocarbon receptor nuclear translocator (ARNT) in fetal, benign hyperplastic, and malignant prostate
    M Kashani
    Department of Urology, University of Vienna, Austria
    Prostate 37:98-108. 1998
    Androgen-dependent tissue has been reported to be affected by chemical ligands of the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, which heterodimerizes with the aryl hydrocarbon receptor nuclear translocator ..
  47. pmc Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
    J Mimura
    Department of Chemistry, Graduate School of Science, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Genes Dev 13:20-5. 1999
    b>Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3, 7,8-tetrachlorodibenzo-p-dioxin on host animals...
  48. ncbi The aryl hydrocarbon receptor: a comparative perspective
    M E Hahn
    Biology Department, Woods Hole Oceanographic Institution, MA 02543 1049, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 121:23-53. 1998
    The aryl hydrocarbon receptor (Ah receptor or AHR) is a ligand-activated transcription factor involved in the regulation of several genes, including those for xenobiotic-metabolizing enzymes such as cytochrome P450 1A and 1B forms...
  49. ncbi Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro
    J M Wong
    Department of Pharmacology, University of Toronto, Ontario, Canada
    Pharmacogenetics 11:85-94. 2001
    The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcriptional regulator of several genes including the cytochrome P4501 (CYP1) family as well as genes encoding factors involved in cell growth and differentiation...
  50. ncbi Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction
    J M Wong
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Biochem Biophys Res Commun 288:990-6. 2001
    The aryl hydrocarbon receptor (AHR) binds xenobiotic chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and regulates transcription of the P4501 subfamily that metabolizes many carcinogens...
  51. ncbi Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2
    Sibel I Karchner
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    J Biol Chem 277:6949-59. 2002
    The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds occur via the aryl hydrocarbon receptor (AHR), a member of the basic helix-loop-helix-Per-ARNT-Sim homology (bHLH-PAS) protein superfamily...
  52. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-alpha and anti-CD40-induced activation of NF-kappaB/Rel in dendritic cells: p50 homodimer activation is not affected
    Carl E Ruby
    Department of Environmental and Molecular Toxicology, and Environmental Health Science Center, Oregon State University, Corvallis, Oregon 97331, USA
    Mol Pharmacol 62:722-8. 2002
    ..Suppression is mediated by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor...
  53. ncbi Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer
    Alexander Koliopanos
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Oncogene 21:6059-70. 2002
    ..In addition, almost all human pancreatic cancer tissues expressed this receptor at high levels, suggesting that these or related compounds may play a role in the therapy of pancreatic cancer in the future...
  54. ncbi Possible involvement of aryl hydrocarbon receptor (AhR) in adult T-cell leukemia (ATL) leukemogenesis: constitutive activation of AhR in ATL
    Toshihisa Hayashibara
    Department of Biochemistry, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1 12 4, Japan
    Biochem Biophys Res Commun 300:128-34. 2003
    ..The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that can influence cell proliferation and ..
  55. ncbi Overexpression of aryl hydrocarbon receptor in human lung carcinomas
    Pinpin Lin
    Institute of Toxicology, Chung Shan Medical University, Taichung, Taiwan, ROC
    Toxicol Pathol 31:22-30. 2003
    Exposure to polycylic aromatic hydrocarbons (PAH) has been associated with increased risk of lung cancer. Aryl hydrocarbon receptor (AhR) is known to play an essential role in PAH-induced toxicity...
  56. pmc Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor
    Eli V Hestermann
    Department of Molecular Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 23:7920-5. 2003
    b>Aryl hydrocarbon receptor (AHR) is a transcription factor whose activity is regulated by environmental agents, including several carcinogenic agonists...
  57. ncbi Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells
    S Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    J Mammary Gland Biol Neoplasia 5:295-306. 2000
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that forms a functional heterodimeric complex with the AhR nuclear translocator (Arnt) protein...
  58. ncbi Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation
    Derek Morrow
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Veterinary Research Building 409, College Station, TX 77843 4466, USA
    J Steroid Biochem Mol Biol 88:27-36. 2004
    LNCaP prostate cancer cells express the aryl hydrocarbon receptor (AhR), and treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces CYP1A1 protein and an Ah-responsive reporter gene...
  59. ncbi A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest
    Tomohiro Ito
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    J Biol Chem 279:25204-10. 2004
    ....
  60. ncbi The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression
    Jennifer L Marlowe
    Center for Environmental Genetics and the Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 279:29013-22. 2004
    ..TCDD is a ligand for the aromatic hydrocarbon receptor (AHR), a ligand-activated transcription factor believed to be the primary mediator of these effects...
  61. ncbi ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription
    Timothy V Beischlag
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:21607-11. 2005
    The aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT) form a heterodimeric transcription factor upon binding a wide variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-..
  62. ncbi The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts
    C A Martey
    Chemistry Department, Shippensburg University, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 289:L391-9. 2005
    ..Herein, we report the central role of the aryl hydrocarbon receptor (AHR) in cigarette smoke extract (CSE)-induced COX-2, microsomal PGE(2) synthase (mPGES), and PGE(2) ..
  63. ncbi The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells
    Xinhai Yang
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    Oncogene 24:7869-81. 2005
    The aryl hydrocarbon receptor (AhR) is an environmental carcinogen-activated transcription factor associated with tumorigenesis...
  64. ncbi Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1998-2003. 2005
    ..They also provide support for an inverse association between CYP1A2*1F and breast cancer, which is consistent with the observation of lower circulating estrogen levels in premenopausal women with the CC genotype in a previous study...
  65. ncbi Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes
    Y Fujii-Kuriyama
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba 305 8577, Japan
    Biochem Biophys Res Commun 338:311-7. 2005
    ..In this review, we briefly summarize our current understanding of the activation and inactivation of AhR activities and discuss the future directions of AhR research...
  66. ncbi Concurrent expression of aryl hydrocarbon receptor and CYP1A1 but not CYP1A1 MspI polymorphism is correlated with gastric cancers raised in Dalian, China
    Jing Xin Ma
    Cancer Institute and Liaoning Key Laboratory of Cancer Genimics, Dalian Medical University, 116027 Dalian, People s Republic of China
    Cancer Lett 240:253-60. 2006
    ..343, P=0.558). The correlation of Aryl hydrocarbon receptor (AhR) with the frequent CYP1A1 expression in stepwise gastrocarcinogenesis was determined by RT-PCR, ..
  67. ncbi Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk
    Ji Rong Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Pharmacogenet Genomics 16:237-43. 2006
    The aryl hydrocarbon receptor (AhR) is a key regulator of the transcriptional expression for the cytochrome P450 1 (CYP1) genes...
  68. ncbi Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells
    Shaheen Khan
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, Texas 77843 4466, USA
    Mol Endocrinol 20:2199-214. 2006
    ..gene is hormone responsive in MCF-7 and ZR-75 breast cancer cells, and this response is inhibited by the aryl hydrocarbon receptor (AhR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
  69. ncbi Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor
    Togo Ikuta
    Research Institute for Clinical Oncology, Saitama Cancer Center, 818 Komuro, Ina machi, Kitaadachi gun, Saitama 362 0806, Japan
    Exp Cell Res 312:3585-94. 2006
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor...
  70. ncbi Aryl hydrocarbon receptor gene polymorphisms affect lung cancer risk
    Jin Hee Kim
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    Lung Cancer 56:9-15. 2007
    ..1, 95% CI, 2.53-14.68). This result suggests that haplotypes of AhR gene play an important role in the development of lung cancer and there is a synergistic interaction between AhR gene and smoking for lung cancer risk...
  71. ncbi Dioxin receptor is a ligand-dependent E3 ubiquitin ligase
    Fumiaki Ohtake
    ERATO, Japan Science and Technology Agency, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    Nature 446:562-6. 2007
    ....
  72. pmc Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation
    Ellen Fritsche
    Institut fur umweltmedizinische Forschung IUF, Auf m Hennekamp 50, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 104:8851-6. 2007
    ..The role of the AhR in the UVB stress response was confirmed in vivo by studies employing AhR KO mice...
  73. pmc RelB, a new partner of aryl hydrocarbon receptor-mediated transcription
    Christoph F A Vogel
    Department of Environmental Toxicology, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Mol Endocrinol 21:2941-55. 2007
    ..We show that the NF-kappaB subunit RelB is functionally associated with the aryl hydrocarbon receptor (AhR) and mediates transcription of chemokines such as IL-8 via activation of AhR and protein kinase A...
  74. ncbi Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue
    Xinhai Yang
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    J Cell Biochem 104:402-17. 2008
    The aryl hydrocarbon receptor (AhR) is a receptor/transcription factor which regulates cytochrome P450 (CYP) gene transcription and which is activated by environmental carcinogens, some of which are associated with increased breast ..
  75. doi Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population
    Dan Chen
    State Key Laboratory of Genetic Engineering and Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    Pharmacogenet Genomics 19:25-34. 2009
    ..carcinogenic effects of polycyclic aromatic hydrocarbons present in tobacco smoke are mediated by the aryl hydrocarbon receptor (AHR), a ligand-dependent transcription factor that regulates tobacco-induced expression of carcinogen ..
  76. pmc Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Exp Med 206:43-9. 2009
    ..interleukin (IL)-6 and transforming growth factor (TGF)-beta, and it is modulated by activation of the aryl hydrocarbon receptor (AhR)...
  77. pmc Ah receptor represses acute-phase response gene expression without binding to its cognate response element
    Rushang D Patel
    Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Lab Invest 89:695-707. 2009
    ..We investigated the potential of the aryl hydrocarbon receptor (AHR) to suppress NF-kappaB regulated-gene expression, especially acute-phase genes, such as serum ..
  78. doi Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women
    Suleeporn Sangrajrang
    Research Division, National Cancer Institute, Ratchathewi, Bangkok, Thailand
    Int J Cancer 125:837-43. 2009
    ..These findings suggest that CYP1A2, CYP2C19, AhR, ERRG and CYP17 polymorphisms may play an important role in estrogen metabolism and modify individual susceptibility to breast cancer in Thai women...
  79. pmc The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
    Emily A Stevens
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53706 1599, USA
    Immunology 127:299-311. 2009
    The aryl hydrocarbon receptor (AHR) is a protein best known for its role in mediating toxicity. Over 30 years of research has uncovered additional roles for the AHR in xenobiotic metabolism and normal vascular development...
  80. pmc Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters
    Shaimaa Ahmed
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Toxicol Sci 111:254-66. 2009
    Recent studies have shown that activated aryl hydrocarbon receptor (AHR) induced the recruitment of estrogen receptor-alpha (ERalpha) to AHR-regulated genes and that AHR is recruited to ERalpha-regulated genes...
  81. pmc Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
    Kaname Kawajiri
    Research Institute for Clinical Oncology and Hospital, Saitama Cancer Center, 818 Komuro, Ina, Saitama, 362 0806, Japan
    Proc Natl Acad Sci U S A 106:13481-6. 2009
    ..The aryl hydrocarbon receptor (AhR) has dual roles in regulating intracellular protein levels both as a ligand-activated transcription ..
  82. doi Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity
    Alexandra Kollara
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Steroid Biochem Mol Biol 118:51-8. 2010
    b>Aryl hydrocarbon receptor (AhR) ligands modulate androgen receptor (AR) signaling in prostate cancer cells through partially defined mechanisms...
  83. pmc The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor
    Jennifer C Schroeder
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 49:393-400. 2010
    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in the regulation of multiple cellular pathways, such as xenobiotic metabolism and Th17 cell differentiation...
  84. pmc Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation
    Julie M Hall
    The Hamner Institutes for Health Sciences, Genomic Biology and Bioinformatics, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 24:359-69. 2010
    ..Cumulatively, these results suggest that the AhR plays an important role in mammary epithelial differentiation and, as such, represent a promising therapeutic target for a range of phenotypically distinct human breast cancers...
  85. pmc The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases
    Fanny L Casado
    Department of Environmental Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Box EHSC, Rochester, NY 14642, USA
    Blood Cells Mol Dis 44:199-206. 2010
    The aryl hydrocarbon receptor (AhR) is a basic helix-loop-helix protein that belongs to the superfamily of environment-sensing PAS (Per-ARNT-Sim) proteins...
  86. ncbi The human AHR: identification of single nucleotide polymorphisms from six ethnic populations
    J Craig Rowlands
    The Dow Chemical Company, Toxicology and Environmental Research and Consulting, Midland, Michigan 48574, USA
    Pharmacogenet Genomics 20:283-90. 2010
    ..and related dioxin-like chemicals are mediated through binding-dependent activation of the cytosolic aryl hydrocarbon receptor (AHR)...
  87. pmc Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling
    Brett C Dinatale
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Center for Molecular Toxicology and Carcinogenesis, University Park, Pennsylvania 16802, USA
    J Biol Chem 285:24388-97. 2010
    The aryl hydrocarbon receptor (AHR) is the ligand-activated transcription factor responsible for mediating the toxicological effects of dioxin and xenobiotic metabolism...
  88. pmc Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    Roopali Gandhi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:846-53. 2010
    The aryl hydrocarbon receptor (AhR) participates in the differentiation of mouse regulatory T cells (T(reg) cells) and interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells), but its role in human T cell differentiation is ..
  89. pmc Role of the xenobiotic receptor in inflammatory bowel disease
    Razvan Arsenescu
    Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, Kentucky 40536, USA
    Inflamm Bowel Dis 17:1149-62. 2011
    ..Dioxin-like compounds can activate the aryl hydrocarbon receptor (AhR) and alter macrophage function as well as T-cell polarization...
  90. doi An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway
    Gaku Tsuji
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Dermatol Sci 62:42-9. 2011
    ..Although BaP has been shown to exert its biological effects via the aryl hydrocarbon receptor (AhR) signaling pathway, the mechanism of its inflammatory effects on skin remains unanswered.
  91. pmc Malignant transformation of mammary epithelial cells by ectopic overexpression of the aryl hydrocarbon receptor
    J Brooks
    Graduate Program in Pharmacology, Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA
    Curr Cancer Drug Targets 11:654-69. 2011
    The aryl hydrocarbon receptor (AhR) is a ligand activated basic helix-loop-helix transcription factor that binds to environmental poly aromatic hydrocarbons (PAH) and mediates their toxic and carcinogenic responses...
  92. doi Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR
    Jun Terashima
    Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University, Japan
    Drug Metab Pharmacokinet 26:577-83. 2011
    Cross-talk between the aryl hydrocarbon receptor (AhR) pathway and the typical stress response is thought to be an important signal transduction in response to nutrient-stress conditions, such as glucose deprivation in liver cells...
  93. doi An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
    Christiane A Opitz
    Department of Neurooncology, Neurology Clinic and National Center for Tumor Diseases, University Hospital of Heidelberg, 69120 Heidelberg, Germany
    Nature 478:197-203. 2011
    Activation of the aryl hydrocarbon receptor (AHR) by environmental xenobiotic toxic chemicals, for instance 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in a variety of cellular processes such as embryogenesis, ..
  94. pmc The aryl hydrocarbon receptor contributes to the proliferation of human medulloblastoma cells
    Daniel P Dever
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Pharmacol 81:669-78. 2012
    The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix (bHLH)/PER-ARNT-SIM (PAS) transcription superfamily, is known to regulate the toxicity of polyaromatic halogenated hydrocarbon environmental ..
  95. ncbi Activation of aryl hydrocarbon receptor mediates indoxyl sulfate-induced monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells
    Ippei Watanabe
    Department of Laboratory Medicine, School of Medicine, Toho University, Tokyo, Japan
    Circ J 77:224-30. 2013
    ..The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates adaptive and toxic responses in cells...
  96. pmc 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation
    Laura MacPherson
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S1A8, Canada
    Nucleic Acids Res 41:1604-21. 2013
    ..poly(ADP-ribose) polymerase (TiPARP/ARTD14) is a member of the PARP family and is regulated by the aryl hydrocarbon receptor (AHR); however, little is known about TiPARP function...
  97. doi The human Ah receptor: hints from dioxin toxicities to deregulated target genes and physiological functions
    Karl Walter Bock
    Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
    Biol Chem 394:729-39. 2013
    ..the review of three well-studied human dioxin toxicities (chloracne, inflammation and cancer) and deregulated Ah receptor (AhR) target genes to obtain hints as to the physiological functions of this receptor...
  98. pmc Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line
    Gennifer D Goode
    Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN
    Int J Cancer 133:2769-80. 2013
    The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that belongs to the basic-helix-loop-helix (bHLH)-Per-ARNT-Sim (PAS) superfamily of transcription factors, mediates toxic response induced by environmental ..
  99. doi The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation
    Laurie Prigent
    UMR INSERM U1085, Institut de Recherche sur la Santé, l Environnement et le Travail IRSET, Universite de Rennes 1, Rennes, France
    Eur J Immunol 44:1330-40. 2014
    The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates immunosuppression caused by a variety of environmental contaminants, such as polycyclic aromatic hydrocarbons or dioxins...
  100. ncbi Roles of xenobiotic receptors in vascular pathophysiology
    Lei Xiao
    Cardiovascular Research Center, School of Medicine, Xi an Jiaotong University
    Circ J 78:1520-30. 2014
    ..receptor (CAR), 2 closely related and liver-enriched members of the nuclear receptor superfamily, and aryl hydrocarbon receptor (AhR), a nonnuclear receptor transcription factor (TF), are major receptors/TFs regulating the ..
  101. ncbi The effect of indole-3-carbinol on the expression of CYP1A1, CYP1B1 and AhR genes and proliferation of MCF-7 cells
    Marta Ociepa-Zawal
    Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland
    Acta Biochim Pol 54:113-7. 2007
    ....

Research Grants70

  1. Ah Receptor and Endothelin-Dependent Hypertension
    Mary K Walker; Fiscal Year: 2010
    ..We propose that the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, influences oxygen-regulation of ET-1 expression and ..
  2. Alvaro Puga; Fiscal Year: 2015
    ..TCDD;dioxin), an organochlorinated environmental pollutant, mediates the aryl hydrocarbon receptor (AHR)-dependent repression of the homeobox transcription factor NKX2...
  3. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ..may be related because PCBs and some pesticides disrupt cells by the same mechanism: activation of the aryl hydrocarbon receptor (AHR) signaling pathway which leads to tissue specific cell cycle arrest...
  4. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcription factor...
  5. Circadian Clock Disruption: A Mechanism for Dioxin-induced Metabolic Syndrome
    Shelley A Tischkau; Fiscal Year: 2013
    ..I explores behavioral circadian rhythms and SCN responses to differences in AhR activation state using aryl hydrocarbon receptor-deficient mice (AhRKO), mice with constitutive activation of AhR (CA-AhR), and wild-type mice treated ..
  6. Norbert E Kaminski; Fiscal Year: 2016
    ..of chemicals belonging to the halogenated aromatic hydrocarbon family that bind and activate the aryl hydrocarbon receptor (AhR)...
  7. SkyScan 1076 In Vivo Micro-Computed Tomography System
    Timothy M Ryan; Fiscal Year: 2010
    ..Molecular Mechanisms of Allergic Asthma Development (R01AI073955-01A2, R01AI065566-04, R01AI051626-07);3) Ah Receptor-Mediated Repression of Acute Phase Gene Expression in a Collagen Antibody Induced Arthritis Mouse Model (..
  8. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2012
    ..We have identified a previously unknown function for a receptor called the aryl hydrocarbon receptor (AhR) as a "down-regulator" of these harmful inflammatory responses...
  9. Thomas R Sutter; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic effects, including carcinogenicity and teratogenicity, of a large class of environmental ..
  10. Barbara Platzer; Fiscal Year: 2015
    ..Research: The proposed project addresses a big gap in our understanding of aryl hydrocarbon receptor (AhR) activation in the gastrointestinal (GI) tract...
  11. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..whether the mechanism of action of dioxin exposure on male gametes involves communication between the aryl hydrocarbon receptor (AhR) and glucose transport...
  12. Developmental Ah receptor Activity in the CNS: Neurogenesis and Neurotoxicity
    Lisa A Opanashuk; Fiscal Year: 2013
    ..TCDD, the most potent dioxin, mediates toxicity via binding to the aryl hydrocarbon receptor (AhR), a ligand-activated member of the bHLH/PAS transcription factor superfamily...
  13. Role of Aryl hydrocarbon receptor (AhR) and RelB during the initiation of dendrit
    Christoph F A Vogel; Fiscal Year: 2010
    This proposal investigates a new mechanism of cross talk between the transcription factors Aryl hydrocarbon Receptor (AhR) and the NF-?B member RelB in the process of dendritic cell (DC) differentiation...
  14. B Paige Lawrence; Fiscal Year: 2016
    ..The actions of these chemicals are mediated through a gene regulatory protein, the aryl hydrocarbon receptor (AhR)...
  15. CHRISTINE PERDAN CURRAN; Fiscal Year: 2014
    ..in mice identified two genes that affect susceptibility to PCB-induced developmental neurotoxicity: the aryl hydrocarbon receptor (AHR) and cytochrome P450 1A2 (CYP1A2)...
  16. Christopher A Bradfield; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the biological effects of polycyclic aromatic hydrocarbons (PAHs), halogenated-dioxins ("dioxins"), - ..
  17. GREGORY DEAN KENNEDY; Fiscal Year: 2016
    ..Interestingly, many proposed chemopreventative agents are known agonists of the aryl hydrocarbon receptor (AHR)...
  18. WARREN NO MIDDLE NAME HEIDEMAN; Fiscal Year: 2015
    ..The receptor for TCDD is the Aryl Hydrocarbon Receptor (AHR), a ligand-activated transcriptional activator...
  19. The role of the aryl hydrocarbon receptor in colon tumorigenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2012
    ..Interestingly, many proposed chemopreventative agents are known agonists of the aryl hydrocarbon receptor (AHR)...
  20. Studies on the Ah Receptors Signaling Mechanism
    William K Chan; Fiscal Year: 2010
    ..It has been well-documented that most, if not all, of the TCDD effects are mediated through the Ah receptor (AhR)...
  21. Roles of pulmonary and hepatic P4501A enzymes in hyperoxic lung injury in mice
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..transcriptional activation of the CYP1A1 or 1A2 promoter, presumably by generating endogenous ligands for the Ah receptor (AHR)...
  22. Robert H Tukey; Fiscal Year: 2016
    ..as a model to study expression of the UGT1 locus, the treatment of mice with compounds that active the Ah receptor (AhR), the pregnenalone X-receptor (PXR), the constitutive androstane receptor (CAR), the peroxisome ..
  23. Ah Receptor Regulation of Prostate Tumor Progression
    Richard Peterson; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The aryl hydrocarbon receptor (AhR) is a transcription factor that binds chlorinated dioxins, other xenobiotics, and various endogenous chemicals and mediates their effects on gene ..
  24. Ah Receptor Anatomy: Implications for Dioxin Toxicity
    CORNELIS JOHAN ELFERINK; Fiscal Year: 2011
    ..Dysregulation in the repair process can lead o liver failure or liver cancer. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor Imctionally identified with proliferative processes...
  25. Studies on the Ah receptor signaling mechanism
    William Chan; Fiscal Year: 2002
    ..It has been well documented that most, if not all, of the TCDD effects are mediated through the Ah receptor (AhR)...
  26. Wen Xie; Fiscal Year: 2016
    ..The aryl hydrocarbon receptor (AhR), highly expressed in the liver, is a transcriptional factor originally cloned as a "xenobiotic ..
  27. A Role of the Ah Receptor in Hematopoiesis: Model Characterization
    Thomas A Gasiewicz; Fiscal Year: 2010
    ..The actions of these chemicals are mediated by a gene regulatory protein, the aryl hydrocarbon receptor (AhR)...
  28. Ah receptor transcriptional regulation through a novel DNA binding site
    SHELLY RENEE WILSON; Fiscal Year: 2012
    Recent studies demonstrate that the aryl hydrocarbon receptor (AhR), a transcription factor, plays an active role in liver homeostasis, and that this process is dysregulated by the environmental toxicant 2,3,7,8- tetrachlorodibenzo-p-..
  29. Gary H Perdew; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Ah receptor (AHR) has been traditionally studied in terms of its ability to mediate transcriptional effects through binding to dioxin-response elements (DRE)...
  30. Gary H Perdew; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Ah receptor (AHR) has traditionally been studied in terms of its ability to mediate transcriptional effects through binding to dioxin-response elements (DRE)...
  31. Genetic Insight Into AH Receptor-Mediated Promotion Of Hepatocarcinogenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant) The objective of this project is to understand the mechanism of Ah receptor-mediated liver tumor promotion using the mouse as a model system...
  32. Ah Receptor Action and Apoptosis
    CORNELIS JOHAN ELFERINK; Fiscal Year: 2010
    ..The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to regulate both apoptotic and proliferative ..
  33. Mitzi Nagarkatti; Fiscal Year: 2015
    ..Interestingly, these compounds can bind to the aryl hydrocarbon receptor (AhR), which is well characterized as a transcription factor that regulates xenobiotic metabolism...
  34. Binoy Shivanna; Fiscal Year: 2016
    ..My main career goal is to become an established investigator with a focus on understanding the role of aryl hydrocarbon receptor (AhR) in hyperoxia-induced developmental lung injury...
  35. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..The secondary objective is to determine if aryl hydrocarbon receptor (AHR) activation affects glucose transporter (GLUT) 1 localization in either the blastocyst stage embryo ..
  36. Transcription Factor Cross-Talk in Developmental Toxicity
    LARISSA WILLIAMS; Fiscal Year: 2012
    ..the embryonic response to toxicant exposure is between two ligand-activated transcription factors -- the aryl hydrocarbon receptor (AHR) and nuclear factor erythroid 2-related factor 2 (NRF2)...
  37. Howard L Weiner; Fiscal Year: 2015
    ..Low dose oral tolerance relies on the induction of Tregs and we have found that the aryl hydrocarbon receptor (AHR) plays an important role in the differentiation of FoxP3+ Treg and IL10+ Tr1 cells...
  38. Wade H Powell; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The aryl hydrocarbon receptor (AHR) mediates the toxicological effects of structurally diverse ligands, including 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD)...
  39. Trevor M Penning; Fiscal Year: 2014
    ..Aim #3, will determine whether the aryl hydrocarbon receptor (AhR) delivers PAH o-quinones to the nucleus to cause oxidative DNA damage...
  40. P53-dependent responses to toxicants in parous and nulliparous breast
    D Joseph Jerry; Fiscal Year: 2010
    ..OCs also provide a comparison for the PAHs as both PAHs and OCs can activate the aryl hydrocarbon receptor (AhR) and perturb endocrine action in the breast...
  41. Liang Zhou; Fiscal Year: 2014
    ..Recently, it has been shown that the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor best known to mediate the effects of environmental toxins ..
  42. PPAR-gamma Signaling in Normal Pilosebaceous Units and in Scarring Alopecia
    Pratima Karnik; Fiscal Year: 2013
    ..Our new data shows that the Aryl Hydrocarbon Receptor (AhR), best known for mediating the toxicity of dioxin, is significantly upregulated in LPP and in the ..
  43. Mark E Hahn; Fiscal Year: 2014
    ..These compounds cause toxicity by activating the aryl hydrocarbon receptor (AHR)...
  44. B Paige Lawrence; Fiscal Year: 2016
    ..that developmental exposure affects the function of the immune system in humans and animal models is aryl hydrocarbon receptor (AhR) ligands...
  45. Michael R Verneris; Fiscal Year: 2016
    ..cell factor (SCF) plays a critical role in HSC commitment to the LTi lineage through the expression of aryl hydrocarbon receptor (AHR)...
  46. Farrah Kheradmand; Fiscal Year: 2016
    ..APCs and our additional preliminary data suggest the presence of a regulatory relationship between the aryl hydrocarbon receptor (AhR), osteopontin (SPP1), and peroxisome proliferator- activated receptor gamma (PPAR-?), an anti-..
  47. Richard P Phipps; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that binds diverse synthetic and natural compounds...
  48. Antagonism of the Ah Receptor in Controlling Breast Cancer Growth and Invasion
    Jennifer J Schlezinger; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Historically, the aryl hydrocarbon receptor (AhR) has been studied for its transcriptional regulation of genes encoding cytochrome P450 enzymes, which metabolize environmental and endogenous ..
  49. RICHARD EUGENE PETERSON; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The long-range goal is to understand how aryl hydrocarbon receptor (AHR) signaling pathway activation affects prostate development and prostate disease...
  50. The Role of the Aryl Hydrocarbon Receptor in Intestinal Immunity
    Liang Zhou; Fiscal Year: 2012
    ..The aryl hydrocarbon receptor (AhR), best known for mediating the effects of environmental toxins, is one of the most upregulated ..
  51. David C Spink; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Since its discovery, the aryl hydrocarbon receptor (AhR) has been recognized as an integral component of the carcinogenic process initiated by smoke-born polycyclic aromatic hydrocarbons and other ..
  52. 3'alpha enhancer regulation by AhR and NF-kappaB/Rel proteins
    COURTNEY ELIZABETH WILLIAMS SULENTIC; Fiscal Year: 2011
    ..chemicals have been attributed to changes in gene expression resulting from the activation of the aryl hydrocarbon receptor (AhR) which subsequently binds to dioxin-responsive elements (ORE) in the affected genes...
  53. Nancy I Kerkvliet; Fiscal Year: 2016
    ..The discovery of a novel approach to induce Tregs is important and timely. The Ah receptor (AhR) is a ligand-activated transcription factor that induces the differentiation of CD4+Tregs...
  54. Michael Steven Denison; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Ah receptor (AhR) is a ligand-dependent transcription factor known to regulate the toxic and biological effects of a variety of exogenous chemicals, such as the toxic halogenated aromatic ..
  55. Francisco J Quintana; Fiscal Year: 2015
    ..involved in the differentiation of Tr1 cells we obtained preliminary data which demonstrate that the Aryl Hydrocarbon Receptor (AHR) plays an important role during the differentiation of Tr1 cells...
  56. Howard L Weiner; Fiscal Year: 2016
    ..We have discovered that IL-27 and the transcription factor aryl hydrocarbon receptor (AhR) play central roles in immune responses in animals and humans and these pathways impinge on all ..
  57. Effect of Resveratrol on Staphylococcal Enterotoxin B induced Vascular Leak
    SADIYE AMCAOGLU RIEDER; Fiscal Year: 2010
    ..interactions in RES- induced apoptosis of T, NK T and dendritic (DC) cells, and (3) test the roles of Aryl hydrocarbon receptor (AhR) and Estrogen receptor (ER) in the upregulation of Fas-FasL, and consequently in the RES-mediated ..
  58. Norbert E Kaminski; Fiscal Year: 2016
    ..g., C57Bl/6) in spite of the fact that the human aryl hydrocarbon receptor (AHR) has approximately ten-fold lower affinity for TCDD than the mouse AHR...
  59. Mechanisms of Reduced Heart Failure Pathogenesis with Phytochemical Intake
    Steven F Bolling; Fiscal Year: 2012
    ..In addition, our comparative studies may suggest classes of phytochemicals that provide superior cardioprotection. ..
  60. Role of AhR During Megakaryopoiesis
    STEPHAN CADET LINDSEY; Fiscal Year: 2011
    ..Well-known as a "toxic sensor," aryl hydrocarbon receptor (AhR) function is normally associated with the action mechanism of various environmental toxins, ..
  61. GREGORY LEE SZETO; Fiscal Year: 2014
    ..The aryl hydrocarbon receptor (AhR) is a unique nexus for signals mediating immunosuppression...
  62. Glucose Transport in Regulation of T Cell Activation and Inflammation
    Jeffrey C Rathmell; Fiscal Year: 2012
    ....
  63. Marina Cella; Fiscal Year: 2016
    ..IL-22 in adaptive and innate cells is under the control of a transcription factor known as Aryl Hydrocarbon Receptor (AHR)...
  64. Genetic Differences in PCB-Induced Behavior
    Daniel Nebert; Fiscal Year: 2009
    ..In rodents to elicit these pathologies, planar PCBs must bind to, and activate, the aryl hydrocarbon receptor (AHR)...
  65. Suppression of Cancer Inflammation with AHR Modulators
    Adam B Glick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Environmental agonists of the Aryl Hydrocarbon Receptor (AHR) such as TCDD (dioxin) and polycyclic aromatic hydrocarbons generate a chronic inflammatory and immunosuppressive tissue microenvironment ..
  66. REGULATION OF NA,K ATPASE BY THE AH RECEPTOR
    Mary Walker; Fiscal Year: 2004
    ..The basic helix-loop-helix-PAS transcription factor, aryl hydrocarbon receptor (AhR), is required for TCDD-induced teratogenicity in mice and likely mediates teratogenicity in other ..
  67. Kameshwar P Singh; Fiscal Year: 2016
    ..Recent data support the novel hypothesis that the aryl hydrocarbon receptor (AhR) is a physiological regulator of HSCs...
  68. Mechanisms of Aryl-Hydrocarbon-Induced Ovotoxicity
    Jonathan Tilly; Fiscal Year: 2005
    ..are particularly intriguing as there exists an intracellular binding protein for PAN termed the aryl hydrocarbon receptor (AHR)...
  69. ENDOGENOUS CYP1B1 SUBSTRATES AS AHR LIGANDS
    Craig Marcus; Fiscal Year: 2003
    1) The Ah receptor (AhR) mediates most of the toxic and tumor promotional properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other Polycyclic Aromatic Hydrocarbons (PAH) in rodents...
  70. AhR-mediated enhancement of the early innate immune response to S. pneumoniae
    BETH VORDERSTRASSE; Fiscal Year: 2009
    The overall goal of this research project is to determine the mechanism by which activation of the aryl hydrocarbon receptor (AhR) protects against pulmonary infection with Streptococcus pneumoniae...