ATG16L1

Summary

Gene Symbol: ATG16L1
Description: autophagy related 16 like 1
Alias: APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy-related protein 16-1, APG16L beta, ATG16 autophagy related 16-like 1, WD repeat domain 30
Species: human

Top Publications

  1. ncbi Barrett's esophagus associates with a variant of IL23R gene
    Pawel Gaj
    Department of Gastroenterology and Hepatology, Medical Center for Postgraduate Education at the Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland
    Acta Biochim Pol 55:365-9. 2008
  2. doi Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene
    Aleixo Muise
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Program in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Expert Rev Mol Diagn 8:465-77. 2008
  3. pmc Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    Ken Cadwell
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 141:1135-45. 2010
  4. pmc Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease
    Lynn Cotterill
    Department of Medical Genetics, Manchester Academic Health, Manchester, United Kingdom
    Can J Gastroenterol 24:297-302. 2010
  5. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
  6. doi rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
    Jurgen Glas
    Department of Medicine II, Grosshadern, University of Munich, Germany
    Am J Gastroenterol 104:665-72. 2009
  7. ncbi Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
    Noboru Mizushima
    PRESTO, Japan Science and Technology Corporation, Kawaguchi 332 0012, Japan
    J Cell Sci 116:1679-88. 2003
  8. ncbi A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    Jochen Hampe
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Nat Genet 39:207-11. 2007
  9. ncbi Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene
    J R Fraser Cummings
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Inflamm Bowel Dis 13:941-6. 2007
  10. ncbi Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
    Keiko Yamazaki
    Laboratory for Gastrointestinal Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    J Hum Genet 52:575-83. 2007

Research Grants

  1. Adherent Escherichia coli and associated virulence genes in children with IBD
    Sandra C Kim; Fiscal Year: 2010
  2. MicroRNA-mediated regulation of ATG16L1 expression and autophagy
    John Kwon; Fiscal Year: 2012
  3. KEN HASHIGIWA CADWELL; Fiscal Year: 2016
  4. David Q Shih; Fiscal Year: 2016
  5. Functional consequences of autophagy mutations in Crohn's disease.
    David L Boone; Fiscal Year: 2012
  6. Effect of Crohn's Disease Risk Alleles on Enteric Microbiota
    Ellen Li; Fiscal Year: 2010
  7. Herbert W Virgin; Fiscal Year: 2014
  8. VANESSA MARIE HUBBARD-LUCEY; Fiscal Year: 2014
  9. Ramnik J Xavier; Fiscal Year: 2014
  10. ALEXANDRIA K MAURER; Fiscal Year: 2015

Detail Information

Publications173 found, 100 shown here

  1. ncbi Barrett's esophagus associates with a variant of IL23R gene
    Pawel Gaj
    Department of Gastroenterology and Hepatology, Medical Center for Postgraduate Education at the Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland
    Acta Biochim Pol 55:365-9. 2008
    ..patients with reflux disease were screened for polymorphisms of CARD15, SLC22A4 (OCTN1), SLC22A5 (OCTN2), DLG5, ATG16L1 and IL23R genes which had previously been found to associate with immune-mediated chronic inflammatory disorders...
  2. doi Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene
    Aleixo Muise
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Program in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Expert Rev Mol Diagn 8:465-77. 2008
    ..Recent studies have identified innate immunity (NOD2), autophagy (ATG16L1) and Th17 pathway (IL23R) genes in the pathogenesis of Crohn's disease...
  3. pmc Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    Ken Cadwell
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 141:1135-45. 2010
    ..that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice...
  4. pmc Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease
    Lynn Cotterill
    Department of Medical Genetics, Manchester Academic Health, Manchester, United Kingdom
    Can J Gastroenterol 24:297-302. 2010
    Variants in the interleukin-23 receptor (IL23R) and the autophagy-related 16-like 1 (ATG16L1) genes have been associated with an increased risk of Crohn's disease (CD)...
  5. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
    ..001). These findings strongly implicate this locus in CD susceptibility and highlight the role of the mucus layer in the development of CD...
  6. doi rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
    Jurgen Glas
    Department of Medicine II, Grosshadern, University of Munich, Germany
    Am J Gastroenterol 104:665-72. 2009
    ..Therefore we aimed to replicate these novel CD susceptibility variants in a large European cohort with inflammatory bowel disease and analyzed potential gene-gene interactions with variants in the NOD2/CARD15, IL23R, and ATG16L1 genes.
  7. ncbi Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
    Noboru Mizushima
    PRESTO, Japan Science and Technology Corporation, Kawaguchi 332 0012, Japan
    J Cell Sci 116:1679-88. 2003
    ..region of this novel protein shows homology with yeast Apg16, we have designated it mouse Apg16-like protein (Apg16L). Apg16L, however, has a large C-terminal domain containing seven WD repeats that is absent from yeast Apg16...
  8. ncbi A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    Jochen Hampe
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Nat Genet 39:207-11. 2007
    ..Disease association of rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1) was replicated in these samples (P = 4.0 x 10(-8)) and confirmed in a UK case-control sample (P = 0.0004)...
  9. ncbi Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene
    J R Fraser Cummings
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Inflamm Bowel Dis 13:941-6. 2007
    A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP) association study identified ATG16L1 as a Crohn's disease (CD) susceptibility gene...
  10. ncbi Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
    Keiko Yamazaki
    Laboratory for Gastrointestinal Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    J Hum Genet 52:575-83. 2007
    ..positive association of CD with the variants in interleukin 23 receptor (IL23R), autophagy-related 16-like 1 (ATG16L1) genes and chromosome 5p13...
  11. ncbi IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease
    Rebecca L Roberts
    Department of Pathology, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Am J Gastroenterol 102:2754-61. 2007
    Recently, separate genome-wide association analyses have identified nonsynonymous SNPs in IL23R and ATG16L1 (rs11209026; c1142G>A, R381Q, and rs2241880; c1338A>G, T300A, respectively) as strong candidate susceptibility factors for ..
  12. ncbi ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands
    Rinse K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, The Netherlands
    Am J Gastroenterol 103:621-7. 2008
    ..The other, rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1), was associated with CD...
  13. ncbi Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe
    J Van Limbergen
    Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Crewe Road South, Edinburgh, UK
    Inflamm Bowel Dis 14:338-46. 2008
    The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults...
  14. ncbi The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
    Jurgen Glas
    Department of Medicine II Grosshadern, University of Munich, Germany
    Am J Gastroenterol 103:682-91. 2008
    We analyzed ATG16L1, a recently identified Crohn's disease (CD) susceptibility gene, in a large cohort with inflammatory bowel disease (IBD) including potential interactions with other IBD genes as well as factors regulating its gene ..
  15. doi ATG16L1 Ala197Thr is not associated with susceptibility to Crohn's disease or with phenotype in an Italian population
    Carlo Perricone
    Gastroenterology 134:368-70. 2008
  16. pmc Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation
    Takashi Itoh
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578, Japan
    Mol Biol Cell 19:2916-25. 2008
    ..In this study, we showed that Golgi-resident small GTPase Rab33B (and Rab33A) specifically interacts with Atg16L, an essential factor in isolation membrane formation, in a guanosine triphosphate-dependent manner...
  17. pmc Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy
    Anna Latiano
    Struttura Complessa di Endoscopia Digestiva, Ospedale Casa Sollievo della Sofferenza I R C C S, Viale Cappuccini 1, San Giovanni Rotondo, Italy
    World J Gastroenterol 14:4643-51. 2008
    ..To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes...
  18. doi Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort
    R K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen and University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Gut 58:388-95. 2009
    ..We assessed the risk for both the development and severity of the disease by combining information from genetic variants associated with inflammatory bowel disease (IBD)...
  19. pmc A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    Ken Cadwell
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 456:259-63. 2008
    ..One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2)...
  20. doi Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
    Rinse K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Am J Gastroenterol 104:630-8. 2009
    ..A genome-wide association scan by the Wellcome Trust Case Control Consortium (WTCCC) recently identified several novel susceptibility loci...
  21. pmc Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts
    Naonobu Fujita
    Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:32602-9. 2009
    A single nucleotide polymorphism in Atg16L1, an autophagy-related gene (ATG), is a risk factor for Crohn disease, a major form of chronic inflammatory bowel disease...
  22. doi Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    Leonardo H Travassos
    Department of Immunology, University of Toronto, Toronto, Canada
    Nat Immunol 11:55-62. 2010
    ..independent of the adaptor RIP2 and transcription factor NF-kappaB, Nod1 and Nod2 recruited the autophagy protein ATG16L1 to the plasma membrane at the bacterial entry site...
  23. pmc Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients
    Veronika Csongei
    Department of Medical Genetics, University of Pecs, Pecs 7624, Hungary
    World J Gastroenterol 16:176-83. 2010
    ..the interaction of interleukin-23 receptor (IL23R) (rs1004819 and rs2201841), autophagy-related 16-like 1 (ATG16L1) (rs2241880), caspase recruitment domain-containing protein 15 (CARD15) genes, and IBD5 locus in Crohn's disease (..
  24. pmc NOD2, IL23R and ATG16L1 polymorphisms in Lithuanian patients with inflammatory bowel disease
    Jurgita Sventoraityte
    Department of Gastroenterology, Kaunas University of Medicine, A Mickeviciaus Street 9, LT 44307 Kaunas, Lithuania
    World J Gastroenterol 16:359-64. 2010
    To investigate the frequency of NOD2, IL23R and ATG16L1 genetic variants in a case-control panel for inflammatory bowel disease (IBD) from Lithuania.
  25. pmc ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
    Craig R Homer
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Gastroenterology 139:1630-41, 1641.e1-2. 2010
    ..We examined the functional interaction between the CD risk genes ATG16L1 and NOD2 to identify an autophagy-dependent pathway that is altered by disease-associated variants.
  26. pmc Plasma membrane contributes to the formation of pre-autophagosomal structures
    Brinda Ravikumar
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
    Nat Cell Biol 12:747-57. 2010
    ..Here we show in mammalian cells that the heavy chain of clathrin interacts with Atg16L1 and is involved in the formation of Atg16L1-positive early autophagosome precursors...
  27. doi Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
    Theo S Plantinga
    Department of Medicine, Radboud University, Nijmegen Medical Centre, internal postal code 463, P O Box 9101, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Gut 60:1229-35. 2011
    ..Genetic variation in the autophagy gene ATG16L1 has been recently implicated in Crohn's disease pathogenesis...
  28. doi Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse
    Manon E Wildenberg
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 142:1493-503.e6. 2012
    Variants in the genes ATG16L1 and IRGM affect autophagy and are associated with the development of Crohn's disease. It is not clear how autophagy is linked to loss of immune tolerance in the intestine...
  29. pmc Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy
    Noor Gammoh
    Cell Biology Department, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 20:144-9. 2013
    ..Here we have identified an interaction between mammalian FIP200 and ATG16L1, essential components of the ULK1 and ATG5 complexes, respectively...
  30. pmc Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2
    Aaron M Ver Heul
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52246, USA
    J Biol Chem 288:6890-902. 2013
    ..binding its downstream targets receptor-interacting protein kinase 2 (RIP2) and autophagy-related protein 16-1 (ATG16L1)...
  31. pmc TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3
    Emilio Boada-Romero
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    EMBO J 32:566-82. 2013
    ..Interestingly, this peptide defines a novel protein motif that mediates interaction with the WD-repeat domain of ATG16L1, thus providing a mechanistic basis for the activity...
  32. pmc FIP200 regulates targeting of Atg16L1 to the isolation membrane
    Taki Nishimura
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    EMBO Rep 14:284-91. 2013
    ..Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14- and phosphatidylinositol 3-kinase-independent manner...
  33. pmc Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin
    Naonobu Fujita
    Department of Genetics, Graduate School of Medicine, 2 Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, 3 Department of Molecular Virology, Research Institute for Microbial Diseases, 4 Department of Host Defense, WPI Immunology Frontier Research Center, 5 Department of Host Defense, Research Institute for Microbial Disease, and 6 Core Instrumentation Facility, Research Institute for Microbial Disease, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Cell Biol 203:115-28. 2013
    ..of the LC3-ubiquitin interaction through adaptor proteins, including a direct interaction between ubiquitin and Atg16L1. To ensure that invading pathogens are captured and degraded, Atg16L1 targeting is secured by two backup systems ..
  34. ncbi Cloning and analysis of human Apg16L
    Huarui Zheng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    DNA Seq 15:303-5. 2004
    ..encoding a putative protein with 607 amino acid residues, which shows 90% identity and 93% similarity to mouse Apg16L. This protein, designated human Apg16L, contains a coiled-coil domain and a motif with seven WD repeats, which are ..
  35. pmc Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    John D Rioux
    Université de Montréal and the Montreal Heart Institute, Research Center, 5000 rue Belanger, Montreal, Quebec H1T 1C8, Canada
    Nat Genet 39:596-604. 2007
    ..1 and a coding variant in ATG16L1, the latter of which was also recently reported by another group...
  36. pmc Searching for genotype-phenotype structure: using hierarchical log-linear models in Crohn disease
    Juliet M Chapman
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Am J Hum Genet 84:178-87. 2009
    ..The ATG16L1.300T-->A variant appears to be directly associated with only disease of the small bowel.
  37. doi Abnormal mucosal immune response to altered bacterial flora following restorative proctocolectomy in patients with ulcerative colitis: serologic measures, immunogenetics, and clinical correlations
    Shehzad Sheikh
    Department of Medicine, Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Center, University of North Carolina FOCiS Center of Excellence, Chapel Hill, NC 27599, USA
    Clin Immunol 127:270-9. 2008
    ..Genome wide screens have also identified NOD2/CARD15, IL23 receptor, and ATG16L1 variants as important in IBD susceptibility and pathogenesis...
  38. doi Innate antimicrobial host defense in small intestinal Crohn's disease
    Maureen J Koslowski
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, D 70376 Stuttgart, Germany
    Int J Med Microbiol 300:34-40. 2010
    ..Besides NOD2 (which is predominantly expressed in PC) and ATG16L1 (inter alia important in the exocytosis of PC products), TCF4 is the third gene which is associated with small ..
  39. doi NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    Rachel Cooney
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Headington, Oxford, UK
    Nat Med 16:90-7. 2010
    ..requires receptor-interacting serine-threonine kinase-2 (RIPK-2), autophagy-related protein-5 (ATG5), ATG7 and ATG16L1 but not NLR family, pyrin domain containing-3 (NALP3)...
  40. ncbi A new avenue to investigate: the autophagic process. From Crohn's disease to Chlamydia
    A S Pena
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Drugs Today (Barc) 45:113-7. 2009
    The finding that a variant (T300A) of the autophagyrelated 16-like 1 (ATG16L1) gene is associated with Crohn's disease suggests that the inability to eliminate intestinal intracellular microbes via (macro)autophagy may be involved in the ..
  41. ncbi Why does Crohn's disease usually occur in terminal ileum?
    Renzo Caprilli
    University of Rome La Sapienza, Via di Novella, 11, 00199, Rome, Italy
    J Crohns Colitis 2:352-6. 2008
    ..Genetic defects in Authophagy-related 16-like gene (ATG16L1) and Immunity-related Guanosine Triphospatase (IRGM) recently found in ileal CD patients lead to a reduction of ..
  42. doi The genetic basis of inflammatory bowel disease
    Rachel Cooney
    Nuffield Department of Medicine, Oxford University, Oxford, UK
    Dig Dis 27:428-42. 2009
    ..In particular, the importance of the innate immune system has been reaffirmed with the identification of IRGM and ATG16L1 genes in the autophagy pathway as CD susceptibility genes...
  43. doi Eating the enemy in Crohn's disease: an old theory revisited
    Renzo Caprilli
    University of Rome La Sapienza, Rome, Italy
    J Crohns Colitis 4:377-83. 2010
    ..of Crohn's disease came from the existence of polymorphism in NOD2 and autophagy-related susceptibility genes (ATG16L1 and IRGM) in patients and from the identification of the presence of adherent-invasive E...
  44. pmc Plasma membrane helps autophagosomes grow
    Brinda Ravikumar
    Department of Medical Genetics, Cambridge, UK
    Autophagy 6:1184-6. 2010
    ..Our study suggests that Atg16L1 interacts with clathrin heavy-chain/AP2 and is also localized on vesicles (positive for clathrin or cholera toxin ..
  45. ncbi Direct link between Atg protein and small GTPase Rab: Atg16L functions as a potential Rab33 effector in mammals
    Mitsunori Fukuda
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan
    Autophagy 4:824-6. 2008
    b>Atg16L is a factor that is essential for elongation of the isolation membrane (also called phagophore), a precursor of the autophagosome...
  46. doi Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    Tatsuya Saitoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 456:264-8. 2008
    ..Here we show that Atg16L1 (autophagy-related 16-like 1), which is implicated in Crohn's disease, regulates endotoxin-induced inflammasome ..
  47. doi IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes
    Mattia Lauriola
    Department of Histology, Embryology and Applied Biology, University of Bologna, I 40126 Bologna, Italy
    Int J Mol Med 27:469-77. 2011
    ..domain containing 2 caspase-activation recruitment domain 15 (NOD2/CARD15), autophagy related 16-like 1 (ATG16L1) and paired-like homeobox 2b (PHOX2B) as susceptibility loci for Crohn's Disease (CD)...
  48. doi Role of autophagy and autophagy genes in inflammatory bowel disease
    Ken Cadwell
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Top Microbiol Immunol 335:141-67. 2009
    Polymorphisms associated with two genes in the autophagy pathway, ATG16L1 and IRGM1, have been implicated in susceptibility to Crohn's disease, an idiopathic inflammatory disease typically involving the gastrointestinal tract...
  49. doi Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
    Simone C Wolfkamp
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam
    Eur J Gastroenterol Hepatol 22:933-7. 2010
    Autophagy-related 16-like 1 gene (ATG16L1) and immunity-related guanosine triphosphatase gene (IRGM) are associated with Crohn's disease susceptibility and autophagy. Elimination of invading pathogens is a function of autophagy...
  50. pmc Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer
    P Brest
    Inserm ERI 21 EA 4319, Faculty of Medicine, University of Nice Sophia Antipolis, Nice, France
    Curr Mol Med 10:486-502. 2010
    ..In 2007, two different autophagy-related genes, ATG16L1 (autophagy-related gene 16-like 1) and IRGM (immunity-related GTPase M) were shown to be specifically involved in ..
  51. doi Abnormalities in the handling of intracellular bacteria in Crohn's disease
    Pierre Lapaquette
    Clermont Universite, Clermont Ferrand, France
    J Clin Gastroenterol 44:S26-9. 2010
    ..of bacterial cell walls (NOD2/CARD15), and for bacterial clearance and antigen processing through autophagy (ATG16L1 and IRGM)...
  52. pmc Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins
    Eisuke Itakura
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Autophagy 6:764-76. 2010
    ..Under starvation conditions, ULK1,Atg14, WIPI-1, LC3 and Atg16L1 target to the same compartment, whereas DFCP1 localizes adjacently to these Atgproteins...
  53. ncbi Pediatric inflammatory bowel disease: clinical and molecular genetics
    Vincent Biank
    Department of Pediatrics, Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Inflamm Bowel Dis 13:1430-8. 2007
    ..of several novel susceptibility loci associated with pediatric-onset Crohn's disease such as IL23R and ATG16L1. These genes join the already confirmed IBD susceptibility genes such as NOD2/CARD15, IBD5, and DLG5...
  54. doi Abnormalities in the handling of intracellular bacteria in Crohn's disease: a link between infectious etiology and host genetic susceptibility
    Anne Lise Glasser
    Pathogenie Bacterienne Intestinale, Universite d Auvergne, JE 2526, USC INRA 2018, Clermont Ferrand, France
    Arch Immunol Ther Exp (Warsz) 56:237-44. 2008
    ..receptors of bacterial cell walls (NOD2/CARD15) and for bacterial clearance and antigen processing via autophagy (ATG16L1 and IRGM)...
  55. doi Genetics of inflammatory bowel disease: clues to pathogenesis
    Hu Zhang
    IBD Genetics Research Group, Addenbrooke s Hospital, Cambridge University, UK
    Br Med Bull 87:17-30. 2008
    ..Substantial progress has been made in the last 2 years in characterizing the susceptibility genes involved...
  56. ncbi Coordinate regulation of autophagy and apoptosis in T cells by death effectors: FADD or foundation
    Bryan D Bell
    Center for Immunology, Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697 3900, USA
    Autophagy 5:238-40. 2009
    ..We observed recruitment of FADD, casp8 and serine/threonine kinase RIPK1 to complexes containing Atg5, Atg12 and Atg16L, suggesting that the generation of early autophagosomes leads to the assembly of complexes that activate casp8...
  57. doi The genetics of Crohn's disease
    Johan Van Limbergen
    Department of Pediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom
    Annu Rev Genomics Hum Genet 10:89-116. 2009
    ..TLR4, CARD9), the differentiation of Th17-lymphocytes (IL-23R, JAK2, STAT3, CCR6, ICOSLG), autophagy (ATG16L1, IRGM, LRRK2), maintenance of epithelial barrier integrity (IBD5, DLG5, PTGER4, ITLN1, DMBT1, XBP1), and the ..
  58. doi Molecular basis of canonical and bactericidal autophagy
    Takeshi Noda
    Department of Cellular Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Int Immunol 21:1199-204. 2009
    ..describe the current understanding of three of the basic components of the canonical autophagy machinery-LC3, the Atg16L complex and phosphatidylinositol 3-phosphate (PI3P)-which are dynamically associated with the autophagic structure...
  59. doi Inflammatory Bowel Diseases: the genetic revolution
    C Jung
    Hopital Robert Debre, Service de gastroentérologie et nutrition pédiatriques, 48, boulevard Serurier, 75019 Paris, France
    Gastroenterol Clin Biol 33:S123-30. 2009
    ..the past, genome-wide scans allowed finding several susceptibility genes for Crohn disease including NOD2, IL23R, ATG16L1, IRGM, TNFSF15, a region close to PTGER4, PTPN2, PTPN22, NKX2-3 and many others...
  60. ncbi NOD2-mediated autophagy and Crohn disease
    Oliver Brain
    Translational Gastroenterology Unit, John Radcliffe Hospital, Headington, Oxford, UK
    Autophagy 6:412-4. 2010
    ..Our recent study shows NOD2 activates autophagy in a manner requiring ATG16L1, another CD susceptibility gene...
  61. pmc Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study
    Jessica J Lee
    Children s Hospital Boston, MA 02115, USA
    Ann Hum Genet 74:489-97. 2010
    ..1 intergenic region (rs10761659) and ATG16L1 (rs10210302), in growth-impaired CD children (OR = 2.36, CI [1.26-4.41] p = 0.0056 and OR = 2.45, CI [1.22-4...
  62. pmc Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy
    Yoshinori Takahashi
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Autophagy 7:61-73. 2011
    ..continuous tubulation and fragmentation to produce cytoplasmic punctate structures that are positive for Rab5, Atg16L and LC3...
  63. ncbi A study in three European IBD cohorts confirms that the ATG16L1 c.898A>G (p.Thr300Ala) variant is a susceptibility factor for Crohn's disease
    Carsten Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Crohns Colitis 1:70-6. 2007
    A recent study reported that a nonsynonymous SNP rs2241880 (c.898A>G, p.Thr300Ala) within ATG16L1 confers susceptibility to Crohn's disease (CD). We analyzed ATG16L1 c...
  64. pmc Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters
    Jeong Sun Ju
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue Saint Louis, MO 63110, USA
    Autophagy 5:511-9. 2009
    ..This autophagic response in skeletal muscle in vivo was abrogated by co-treatment with chloroquine and in ATG16L1 hypomorphic mice...
  65. doi Update on genetics in inflammatory disease
    Casper G Noomen
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, C4 12 Leiden, The Netherlands
    Best Pract Res Clin Gastroenterol 23:233-43. 2009
    ..gene variants have been identified and replicated, the two most widely replicated being variants in the IL23R and ATG16L1 genes...
  66. doi Bacterial invasion: linking autophagy and innate immunity
    Lorenzo Galluzzi
    INSERM, U848, F 94805 Villejuif, France Institut Gustave Roussy, F 94805 Villejuif, France
    Curr Biol 20:R106-8. 2010
    ..with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity ..
  67. pmc The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
    Maria Filimonenko
    Centre for Cancer Biomedicine, University of Oslo, Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cell 38:265-79. 2010
    ..inclusions and scaffolds a complex between p62(SQSTM1)-positive proteins and the autophagic effectors Atg5, Atg12, Atg16L, and LC3...
  68. pmc Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
    Daniel N Frank
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80045, USA
    Inflamm Bowel Dis 17:179-84. 2011
    ..We hypothesize that NOD2 and ATG16L1 risk alleles may be associated with these alterations.
  69. ncbi The role of genetics in inflammatory bowel disease
    Liesbet Henckaerts
    Department of Gastroenterology University Hospital Gasthuisberg, Leuven, Belgium
    Curr Drug Targets 9:361-8. 2008
    ..association studies (WGAS) have now become possible and have identified additional genes (IL23R, IRGM, PTGER4, ATG16L1) for Crohn's disease and ulcerative colitis, that have subsequently been replicated...
  70. pmc Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease
    Marla C Dubinsky
    Department of Pediatrics and Medicine, Inflammatory Bowel Disease Program, Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 16:1357-66. 2010
    ..The aim was to test associations of known IBD susceptibility loci and novel "pharmacogenetic" GWAS identified loci with primary nonresponse to anti-TNFalpha in pediatric IBD patients and develop a predictive model of primary nonresponse...
  71. ncbi Negative regulators in Toll-like receptor responses
    Shizuo Akira
    From the Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
    Cornea 29:S13-9. 2010
    ..We recently generated mutant mice lacking Atg16L1, an autophagy-related gene that is implicated in Crohn's disease, and thereby examined its role in TLR-mediated ..
  72. doi Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cells
    Michael Scharl
    Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
    Inflamm Bowel Dis 18:1287-302. 2012
    ..tyrosine phosphatase nonreceptor type 2 (PTPN2), and autophagy genes, such as autophagy-related 16-like 1 (ATG16L1), with chronic inflammatory disorders, such as Crohn's disease (CD)...
  73. pmc Role of genetics in the diagnosis and prognosis of Crohn's disease
    Epameinondas V Tsianos
    1st Division of Internal Medicine and Hepato Gastroenterology Unit, Department of Medicine, Medical School, University of Ioannina, Leoforos Stavrou Niarxou, PO Box 1186, 45110 Ioannina, Greece
    World J Gastroenterol 18:105-18. 2012
    ..So far, the most strong and replicated associations with Crohn's disease have been done with NOD2, IL23R and ATG16L1 genes...
  74. doi NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans
    Esmeralda Juarez
    Department of Microbiology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
    Eur J Immunol 42:880-9. 2012
    ..In addition, the autophagy proteins IRGM, LC3 and ATG16L1 were recruited to the bacteria-containing autophagosome after treatment with MDP...
  75. pmc Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition
    Ellen Li
    Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 7:e26284. 2012
    ..These subjects also were genotyped for the three major NOD2 risk alleles (Leu1007fs, R708W, G908R) and the ATG16L1 risk allele (T300A)...
  76. pmc Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans
    Deepa Raju
    Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    Autophagy 8:1387-8. 2012
    ..We also determined that the Crohn disease susceptibility polymorphism in the essential autophagy gene ATG16L1 increases susceptibility to H. pylori infection...
  77. pmc SNP-SNP interactions discovered by logic regression explain Crohn's disease genetics
    Irina Dinu
    School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 7:e43035. 2012
    ..g., il23r, nod2, cyld, nkx2-3, il12rb2, atg16l1)...
  78. pmc A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection
    Amanda M Marchiando
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 14:216-24. 2013
    Polymorphisms in the essential autophagy gene Atg16L1 have been linked with susceptibility to Crohn's disease, a major type of inflammatory bowel disease (IBD)...
  79. doi Association of Egr-1 and autophagy-related gene polymorphism in men with chronic obstructive pulmonary disease
    Chiung Zuei Chen
    Division of Chest Medicine, Department of Internal Medicine, National Cheng Kung University Hospital, Medical College, National Cheng Kung University, Tainan, Taiwan
    J Formos Med Assoc 114:750-5. 2015
    ..been identified: Egr-1 (early growth response), associated with different phenotype expressions in asthma; and, Atg16L1 (autophagy related 16-like 1), a candidate gene responsible for susceptibility to chronic inflammatory diseases...
  80. pmc Diverse autophagosome membrane sources coalesce in recycling endosomes
    Claudia Puri
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Cell 154:1285-99. 2013
    ..traffics from the plasma membrane to recycling endosomes in carriers that appear to be routed differently from ATG16L1-containing vesicles, another source of autophagosome membrane...
  81. pmc MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy
    Changming Lu
    Division of Hematology and Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama
    Gastroenterology 146:188-99. 2014
    ..of the microRNAs (miRs) MIR106B and MIR93 in induction of autophagy and bacterial clearance in human cell lines and the correlation between MIR106B and autophagy-related gene 16L1 (ATG16L1) expression in tissues from patients with CD.
  82. doi Interleukin-1β in innate inflammation, autophagy and immunity
    Leo A B Joosten
    Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Semin Immunol 25:416-24. 2013
    ..A role for autophagy in production of IL-1β has emerged with deletion of the autophagy gene ATG16L1. Macrophages from ATG16L1-deficient mice produce higher levels of IL-1β after stimulation with TLR4 ligands via ..
  83. doi Decoding norovirus infection in Crohn's disease
    Mathias Chamaillard
    Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France CNRS, UMR 8204, Lille, France Institut National de la Santé et de la Recherche Médicale, U1019, Team 7, Equipe FRM, Lille, France Univ Lille Nord de France, Lille, France and Université Lille 2, Faculte de Medecine, CHRU de Lille, Laboratoire de Virologie EA3610, Loos Lez Lille, France
    Inflamm Bowel Dis 20:767-70. 2014
    ..these findings, host variations in additional genes involved in host response to norovirus infection (such as ATG16L1 and NOD2) predispose humans to Crohn's ileitis...
  84. pmc A CARD9 polymorphism is associated with decreased likelihood of persistent conjugated hyperbilirubinemia in intestinal failure
    Karolina Maria Burghardt
    Group for Improvement of Intestinal Function and Treatment GIFT, Transplant Centre, Toronto, Ontario, Canada Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Toronto, Ontario, Canada
    PLoS ONE 9:e85915. 2014
    ..Therefore, we sought to determine if polymorphisms in the NOD2 signaling cascade, including NOD2, CARD9, RAC1 and ATG16L1 are associated with intestinal failure (IF) or its complications...
  85. doi Association of autophagy-related 16-like 1 (ATG16L1) gene polymorphism with sepsis severity in patients with sepsis and ventilator-associated pneumonia
    A Savva
    4th Department of Internal Medicine, Attikon University Hospital, University of Athens, Medical School, 1 Rimini Str, 12462, Athens, Greece
    Eur J Clin Microbiol Infect Dis 33:1609-14. 2014
    ..Mechanically ventilated patients with VAP were studied. Genotyping for autophagy-related 16-like 1 (ATG16L1, rs2241880) functional polymorphism was performed using the TaqMan single-nucleotide assay...
  86. pmc WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1
    Hannah C Dooley
    London Research Institute, Cancer Research UK, 44 Lincolns Inn Fields, London WC2A 3LY, UK
    Mol Cell 55:238-52. 2014
    ..By identifying interacting partners of WIPIs, WD-repeat PtdIns(3)P effector proteins, we found that Atg16L1 directly binds WIPI2b...
  87. doi The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients
    Mehdi Sadaghian Sadabad
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Gut 64:1546-52. 2015
    Crohn's disease (CD) is caused by a complex interplay among genetic, microbial and environmental factors. ATG16L1 is an important genetic factor involved in innate immunity, including autophagy and phagocytosis of microbial components ..
  88. pmc WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1
    Hannah C Dooley
    a London Research Institute Cancer Research UK London, UK
    Autophagy 11:190-1. 2015
    ..In a recent study, we reported that WIPI2B directly binds ATG16L1 and functions by recruiting the ATG12-ATG5-ATG16L1 complex to forming autophagosomes during starvation- or ..
  89. doi Genetic determinants of quantitative traits associated with cardiovascular disease risk
    Bozena Smolkova
    Department of Experimental and Applied Genetics, Slovak Medical University, 83303 Bratislava, Slovakia Electronic address
    Mutat Res 778:18-25. 2015
    ..Prior to multiple testing correction, univariate analysis associated APOE rs429358, rs7412 and ATG16L1 rs2241880 variants with serum lipid levels, while LEPR rs1137100 and ATG16L1 rs2241880 variants were linked to ..
  90. pmc Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
    Hiutung Chu
    Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Science 352:1116-20. 2016
    ..We reveal that OMVs require IBD-associated genes, ATG16L1 and NOD2, to activate a noncanonical autophagy pathway during protection from colitis...
  91. ncbi Association between ATG16L1 gene polymorphism and the risk of Crohn's disease
    Bei bei Zhang
    Department of Medical Affairs, General Hospital of PLA Chengdu Military Area Command, Chengdu, China
    J Int Med Res . 2016
    To perform a meta-analysis to evaluate studies investigating the association between ATG16L1 gene polymorphism and Crohn's disease.
  92. pmc Variants in autophagy-related genes and clinical characteristics in melanoma: a population-based study
    Kirsten A M White
    Department of Medicine, Division of Epidemiology, University of New Mexico, Albuquerque, New Mexico
    Cancer Med 5:3336-3345. 2016
    ..We examined five single-nucleotide polymorphisms (SNPs) in three ATG genes (ATG5; ATG10; and ATG16L) with known or suspected impact on autophagic flux in an international population-based case-control study of ..
  93. doi The genetic background of inflammatory bowel disease: from correlation to causality
    Werna Tc Uniken Venema
    Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    J Pathol 241:146-158. 2017
    ..We highlight important causal genetic variants in the candidate genes NOD2, ATG16L1, IRGM, IL23R, CARD9, RNF186, and PRDM1...
  94. doi Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
    Hannah E J Polson
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
    Autophagy 6:506-22. 2010
    ..WIPI2 is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes...
  95. doi Functional consequences of mutations in the autophagy genes in the pathogenesis of Crohn's disease
    Oliver Brain
    TGU, John Radcliffe Hospital, Oxford, UK
    Inflamm Bowel Dis 18:778-81. 2012
    ..The associated polymorphisms in ATG16L1 and IRGM have been confirmed, and functional studies have begun to shed light on how they link to CD pathogenesis...
  96. pmc Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation
    Mario Mauthe
    Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany
    Autophagy 7:1448-61. 2011
    ..In line with this, resveratrol did not promote phagophore localization of WIPI-1, WIPI-2 or the Atg16L complex above basal level...
  97. doi Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
    Eisuke Itakura
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Cell Sci 125:1488-99. 2012
    ..Structures containing upstream Atg proteins, including ULK1, Atg14, DFCP1, WIPI-1 and Atg16L1, can associate with depolarized mitochondria even in the absence of membrane-bound LC3...
  98. doi Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response
    Pierre Lapaquette
    Clermont Universite, Universite d Auvergne, UMR Inserm Université d Auvergne U1071, USC INRA 2018, Clermont Ferrand, France
    Cell Microbiol 14:791-807. 2012
    ..CD-associated polymorphisms in NOD2, ATG16L1 and IRGM affect bacterial autophagy, a crucial innate immunity mechanism...
  99. pmc A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate
    Dandan Chen
    Division of Biochemistry, Biophysics, and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 45:629-41. 2012
    ....
  100. pmc Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease
    Maureen J Koslowski
    Dr Margarete Fischer Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
    PLoS Genet 8:e1002523. 2012
    ..Different ileal CD-associated genes including NOD2, ATG16L1, and recently the β-catenin-dependant Wnt transcription factor TCF7L2 have been linked to impaired PC ..

Research Grants29

  1. Adherent Escherichia coli and associated virulence genes in children with IBD
    Sandra C Kim; Fiscal Year: 2010
    ..Specific aim 2: Determine if polymorphisms of genes that regulate bacterial processing and killing (NOD2, ATG16L1, IRGM) are associated with (a) mucosal colonization in the intestine of AIEC, and (b) increased E...
  2. MicroRNA-mediated regulation of ATG16L1 expression and autophagy
    John Kwon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant) ATG16L1 was recently identified in genome-wide association studies as a Crohn's disease susceptibility gene, thereby implicating autophagy in the pathogenesis of Crohn's disease...
  3. KEN HASHIGIWA CADWELL; Fiscal Year: 2016
    ..b>Atg16L1 and Nod2 are two Crohn's disease susceptibility genes that have received much attention because of their ..
  4. David Q Shih; Fiscal Year: 2016
    ..identified several IBD associated genes including intracellular pattern recognition sensor NOD2, autophagy genes (ATG16L1 and IRGM) and tumor necrosis factor superfamily member 15 (TNFSF15)...
  5. Functional consequences of autophagy mutations in Crohn's disease.
    David L Boone; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Genome wide scans (GWS) have implicated two autophagy genes, ATG16L1 and IRGM, in Crohn's disease (CD), thus implicating autophagy in the pathology of CD...
  6. Effect of Crohn's Disease Risk Alleles on Enteric Microbiota
    Ellen Li; Fiscal Year: 2010
    ..Crohn's disease (CD) risk alleles, such as the NOD2 and ATG16L1, have been associated with defective host containment of commensal bacteria...
  7. Herbert W Virgin; Fiscal Year: 2014
    ..phenotypes in mice carrying a mutation in the Crohn's disease susceptibility-linked autophagy gene Atg16L1. Susceptibility to Crohn's disease, an inflammatory disease involving the ileum, is controlled in part by a ..
  8. VANESSA MARIE HUBBARD-LUCEY; Fiscal Year: 2014
    ..One of these risk factors, Atg16L1, a gene important for autophagy, has been shown to be critical for IBD development and may influence mortality in ..
  9. Ramnik J Xavier; Fiscal Year: 2014
    ..Ocean State Crohn's and Colitis Area Registry, an inception cohort in Rhode Island) to enroll subjects with ATG16L1, IRGM, and NOD2 disease-associated variants, as well as healthy individuals with and without these risk alleles...
  10. ALEXANDRIA K MAURER; Fiscal Year: 2015
    ..Additionally, commensal bacteria in the intestine are thought to contribute to disease. Atg16L1 is an autophagy gene associated with increased susceptibility of developing the inflammatory bowel disease (IBD) ..
  11. Indira U Mysorekar; Fiscal Year: 2016
    ..We recently showed that an autophagy gene, Atg16L1, plays a key role in UTI pathogenesis: a mutation in the Atg16L1 gene limits the ability of UPEC to persist and ..
  12. BROC TAYLOR MCCUNE; Fiscal Year: 2015
    ..We will test if Dap1 deficiency protects mice from gastrointestinal pathologies occurring in mice hypomorphic for Atg16L1 after virus infection, determine if Dap1-/- mice are resistant to colitis induced by IL10 deficiencies, and ..
  13. MACROPHAGE GENE EXPRESSION IN MUCOSAL INFLAMMATION
    Scott E Plevy; Fiscal Year: 2010
    ..Specifically, the CD susceptibility genes CARD15, ATG16L1, and IRGM all have important roles in host-microbial responses;including sensing of microbial;products, ..
  14. Jianzhong Hu; Fiscal Year: 2015
    ..Over 70 susceptibility loci, particularly immune response genes such as NOD2/CARD15, IRGM and ATG16L1, have been associated with CD risk in individuals of European ancestry...
  15. John D Rioux; Fiscal Year: 2016
    ..What is equally clear, although there are some notable exceptions (e.g. IL23R, ATG16L1) GWA studies have not directly led to the causal genes or specific functional variants, and this has greatly ..
  16. Autophagy and Nod2 Function in Crohn's Disease
    CHRISTINE L MCDONALD; Fiscal Year: 2013
    ..in CD and lead us to propose the following central hypothesis: CD- associated mutations in the autophagy genes, ATG16L1 (autophagy related 16-like protein 1) and IRGM (immunity-related GTPase family, M), and NOD2 impair the same ..
  17. Ramnik J Xavier; Fiscal Year: 2016
    ..role for autophagy in Crohn's disease (CD)1, revealing a coding polymorphism in the autophagy gene ATG16L1 that is associated with increased risk of CD4...
  18. Autophagy in Tuberculosis
    VOJO P DERETIC; Fiscal Year: 2011
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  19. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2008
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  20. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2006
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  21. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2006
    ..abstract_text> ..
  22. Identifying Disease Variants for Familial Crohns Disease
    Steven R Brant; Fiscal Year: 2010
    ..With this study, we will test 9000 gene markers in these regions and identify the specific genes and, by gene sequencing, the specific DNA abnormalities that result in a significant proportion of familial Crohn's disease. ..
  23. Mapping Chromosome 3q Inflammatory Bowel Disease Genes
    JUDY CHO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. Crohn's Disease Gene Mapping of Chromosome 16
    STEVEN BRANT; Fiscal Year: 2005
    ..Defining the IBD1 mutation for CD will be a major step in unraveling the etiology and pathophysiology of this enigmatic disease, improve genetic counseling and make possible novel preventative and therapeutic strategies. ..
  26. IDENTIFYING MAJOR SUSCEPTIBILITY GENES OF IBD
    JUDY CHO; Fiscal Year: 2003
    ..Once risk alleles are identified in multiplex families, characterization of the nature and broad significance of specific risk alleles for IBD in a variety of populations will be performed. ..
  27. FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITIS
    John Reveille; Fiscal Year: 2003
    ..abstract_text> ..
  28. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
    ..Ultimately, the outcome of this study will go a long way toward clearing up the MAP debate. ..