Genomes and Genes
Gene Symbol: ATG16L1
Description: autophagy related 16 like 1
Alias: APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy-related protein 16-1, APG16L beta, ATG16 autophagy related 16-like 1, WD repeat domain 30
Publications173 found, 100 shown here
- Barrett's esophagus associates with a variant of IL23R genePawel Gaj
Department of Gastroenterology and Hepatology, Medical Center for Postgraduate Education at the Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland
Acta Biochim Pol 55:365-9. 2008..patients with reflux disease were screened for polymorphisms of CARD15, SLC22A4 (OCTN1), SLC22A5 (OCTN2), DLG5, ATG16L1 and IL23R genes which had previously been found to associate with immune-mediated chronic inflammatory disorders...
- Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS geneAleixo Muise
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Program in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Expert Rev Mol Diagn 8:465-77. 2008..Recent studies have identified innate immunity (NOD2), autophagy (ATG16L1) and Th17 pathway (IL23R) genes in the pathogenesis of Crohn's disease...
- Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestineKen Cadwell
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Cell 141:1135-45. 2010..that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice...
- Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's diseaseLynn Cotterill
Department of Medical Genetics, Manchester Academic Health, Manchester, United Kingdom
Can J Gastroenterol 24:297-302. 2010Variants in the interleukin-23 receptor (IL23R) and the autophagy-related 16-like 1 (ATG16L1) genes have been associated with an increased risk of Crohn's disease (CD)...
- Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's diseaseDermot P B McGovern
Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Hum Mol Genet 19:3468-76. 2010..001). These findings strongly implicate this locus in CD susceptibility and highlight the role of the mucus layer in the development of CD...
- rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German populationJurgen Glas
Department of Medicine II, Grosshadern, University of Munich, Germany
Am J Gastroenterol 104:665-72. 2009..Therefore we aimed to replicate these novel CD susceptibility variants in a large European cohort with inflammatory bowel disease and analyzed potential gene-gene interactions with variants in the NOD2/CARD15, IL23R, and ATG16L1 genes.
- Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugateNoboru Mizushima
PRESTO, Japan Science and Technology Corporation, Kawaguchi 332 0012, Japan
J Cell Sci 116:1679-88. 2003..region of this novel protein shows homology with yeast Apg16, we have designated it mouse Apg16-like protein (Apg16L). Apg16L, however, has a large C-terminal domain containing seven WD repeats that is absent from yeast Apg16...
- A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1Jochen Hampe
Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, University Hospital Schleswig Holstein, 24105 Kiel, Germany
Nat Genet 39:207-11. 2007..Disease association of rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1) was replicated in these samples (P = 4.0 x 10(-8)) and confirmed in a UK case-control sample (P = 0.0004)...
- Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility geneJ R Fraser Cummings
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
Inflamm Bowel Dis 13:941-6. 2007A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP) association study identified ATG16L1 as a Crohn's disease (CD) susceptibility gene...
- Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patientsKeiko Yamazaki
Laboratory for Gastrointestinal Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
J Hum Genet 52:575-83. 2007..positive association of CD with the variants in interleukin 23 receptor (IL23R), autophagy-related 16-like 1 (ATG16L1) genes and chromosome 5p13...
- IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel diseaseRebecca L Roberts
Department of Pathology, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
Am J Gastroenterol 102:2754-61. 2007Recently, separate genome-wide association analyses have identified nonsynonymous SNPs in IL23R and ATG16L1 (rs11209026; c1142G>A, R381Q, and rs2241880; c1338A>G, T300A, respectively) as strong candidate susceptibility factors for ..
- ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the NetherlandsRinse K Weersma
Department of Gastroenterology and Hepatology, University Medical Center Groningen, The Netherlands
Am J Gastroenterol 103:621-7. 2008..The other, rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1), was associated with CD...
- Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern EuropeJ Van Limbergen
Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Crewe Road South, Edinburgh, UK
Inflamm Bowel Dis 14:338-46. 2008The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults...
- The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German populationJurgen Glas
Department of Medicine II Grosshadern, University of Munich, Germany
Am J Gastroenterol 103:682-91. 2008We analyzed ATG16L1, a recently identified Crohn's disease (CD) susceptibility gene, in a large cohort with inflammatory bowel disease (IBD) including potential interactions with other IBD genes as well as factors regulating its gene ..
- ATG16L1 Ala197Thr is not associated with susceptibility to Crohn's disease or with phenotype in an Italian populationCarlo Perricone
Gastroenterology 134:368-70. 2008
- Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formationTakashi Itoh
Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578, Japan
Mol Biol Cell 19:2916-25. 2008..In this study, we showed that Golgi-resident small GTPase Rab33B (and Rab33A) specifically interacts with Atg16L, an essential factor in isolation membrane formation, in a guanosine triphosphate-dependent manner...
- Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in ItalyAnna Latiano
Struttura Complessa di Endoscopia Digestiva, Ospedale Casa Sollievo della Sofferenza I R C C S, Viale Cappuccini 1, San Giovanni Rotondo, Italy
World J Gastroenterol 14:4643-51. 2008..To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes...
- Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohortR K Weersma
Department of Gastroenterology and Hepatology, University Medical Center Groningen and University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
Gut 58:388-95. 2009..We assessed the risk for both the development and severity of the disease by combining information from genetic variants associated with inflammatory bowel disease (IBD)...
- A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cellsKen Cadwell
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 456:259-63. 2008..One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2)...
- Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohortRinse K Weersma
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
Am J Gastroenterol 104:630-8. 2009..A genome-wide association scan by the Wellcome Trust Case Control Consortium (WTCCC) recently identified several novel susceptibility loci...
- Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblastsNaonobu Fujita
Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
J Biol Chem 284:32602-9. 2009A single nucleotide polymorphism in Atg16L1, an autophagy-related gene (ATG), is a risk factor for Crohn disease, a major form of chronic inflammatory bowel disease...
- Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entryLeonardo H Travassos
Department of Immunology, University of Toronto, Toronto, Canada
Nat Immunol 11:55-62. 2010..independent of the adaptor RIP2 and transcription factor NF-kappaB, Nod1 and Nod2 recruited the autophagy protein ATG16L1 to the plasma membrane at the bacterial entry site...
- Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patientsVeronika Csongei
Department of Medical Genetics, University of Pecs, Pecs 7624, Hungary
World J Gastroenterol 16:176-83. 2010..the interaction of interleukin-23 receptor (IL23R) (rs1004819 and rs2201841), autophagy-related 16-like 1 (ATG16L1) (rs2241880), caspase recruitment domain-containing protein 15 (CARD15) genes, and IBD5 locus in Crohn's disease (..
- NOD2, IL23R and ATG16L1 polymorphisms in Lithuanian patients with inflammatory bowel diseaseJurgita Sventoraityte
Department of Gastroenterology, Kaunas University of Medicine, A Mickeviciaus Street 9, LT 44307 Kaunas, Lithuania
World J Gastroenterol 16:359-64. 2010To investigate the frequency of NOD2, IL23R and ATG16L1 genetic variants in a case-control panel for inflammatory bowel disease (IBD) from Lithuania.
- ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesisCraig R Homer
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Gastroenterology 139:1630-41, 1641.e1-2. 2010..We examined the functional interaction between the CD risk genes ATG16L1 and NOD2 to identify an autophagy-dependent pathway that is altered by disease-associated variants.
- Plasma membrane contributes to the formation of pre-autophagosomal structuresBrinda Ravikumar
Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
Nat Cell Biol 12:747-57. 2010..Here we show in mammalian cells that the heavy chain of clathrin interacts with Atg16L1 and is involved in the formation of Atg16L1-positive early autophagosome precursors...
- Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2Theo S Plantinga
Department of Medicine, Radboud University, Nijmegen Medical Centre, internal postal code 463, P O Box 9101, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
Gut 60:1229-35. 2011..Genetic variation in the autophagy gene ATG16L1 has been recently implicated in Crohn's disease pathogenesis...
- Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapseManon E Wildenberg
Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
Gastroenterology 142:1493-503.e6. 2012Variants in the genes ATG16L1 and IRGM affect autophagy and are associated with the development of Crohn's disease. It is not clear how autophagy is linked to loss of immune tolerance in the intestine...
- Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagyNoor Gammoh
Cell Biology Department, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Struct Mol Biol 20:144-9. 2013..Here we have identified an interaction between mammalian FIP200 and ATG16L1, essential components of the ULK1 and ATG5 complexes, respectively...
- Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2Aaron M Ver Heul
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52246, USA
J Biol Chem 288:6890-902. 2013..binding its downstream targets receptor-interacting protein kinase 2 (RIP2) and autophagy-related protein 16-1 (ATG16L1)...
- TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3Emilio Boada-Romero
Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
EMBO J 32:566-82. 2013..Interestingly, this peptide defines a novel protein motif that mediates interaction with the WD-repeat domain of ATG16L1, thus providing a mechanistic basis for the activity...
- FIP200 regulates targeting of Atg16L1 to the isolation membraneTaki Nishimura
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
EMBO Rep 14:284-91. 2013..Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14- and phosphatidylinositol 3-kinase-independent manner...
- Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitinNaonobu Fujita
Department of Genetics, Graduate School of Medicine, 2 Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, 3 Department of Molecular Virology, Research Institute for Microbial Diseases, 4 Department of Host Defense, WPI Immunology Frontier Research Center, 5 Department of Host Defense, Research Institute for Microbial Disease, and 6 Core Instrumentation Facility, Research Institute for Microbial Disease, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
J Cell Biol 203:115-28. 2013..of the LC3-ubiquitin interaction through adaptor proteins, including a direct interaction between ubiquitin and Atg16L1. To ensure that invading pathogens are captured and degraded, Atg16L1 targeting is secured by two backup systems ..
- Cloning and analysis of human Apg16LHuarui Zheng
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
DNA Seq 15:303-5. 2004..encoding a putative protein with 607 amino acid residues, which shows 90% identity and 93% similarity to mouse Apg16L. This protein, designated human Apg16L, contains a coiled-coil domain and a motif with seven WD repeats, which are ..
- Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesisJohn D Rioux
Université de Montréal and the Montreal Heart Institute, Research Center, 5000 rue Belanger, Montreal, Quebec H1T 1C8, Canada
Nat Genet 39:596-604. 2007..1 and a coding variant in ATG16L1, the latter of which was also recently reported by another group...
- Searching for genotype-phenotype structure: using hierarchical log-linear models in Crohn diseaseJuliet M Chapman
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Am J Hum Genet 84:178-87. 2009..The ATG16L1.300T-->A variant appears to be directly associated with only disease of the small bowel.
- Abnormal mucosal immune response to altered bacterial flora following restorative proctocolectomy in patients with ulcerative colitis: serologic measures, immunogenetics, and clinical correlationsShehzad Sheikh
Department of Medicine, Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Center, University of North Carolina FOCiS Center of Excellence, Chapel Hill, NC 27599, USA
Clin Immunol 127:270-9. 2008..Genome wide screens have also identified NOD2/CARD15, IL23 receptor, and ATG16L1 variants as important in IBD susceptibility and pathogenesis...
- Innate antimicrobial host defense in small intestinal Crohn's diseaseMaureen J Koslowski
Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, D 70376 Stuttgart, Germany
Int J Med Microbiol 300:34-40. 2010..Besides NOD2 (which is predominantly expressed in PC) and ATG16L1 (inter alia important in the exocytosis of PC products), TCF4 is the third gene which is associated with small ..
- NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentationRachel Cooney
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Headington, Oxford, UK
Nat Med 16:90-7. 2010..requires receptor-interacting serine-threonine kinase-2 (RIPK-2), autophagy-related protein-5 (ATG5), ATG7 and ATG16L1 but not NLR family, pyrin domain containing-3 (NALP3)...
- A new avenue to investigate: the autophagic process. From Crohn's disease to ChlamydiaA S Pena
Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Drugs Today (Barc) 45:113-7. 2009The finding that a variant (T300A) of the autophagyrelated 16-like 1 (ATG16L1) gene is associated with Crohn's disease suggests that the inability to eliminate intestinal intracellular microbes via (macro)autophagy may be involved in the ..
- Why does Crohn's disease usually occur in terminal ileum?Renzo Caprilli
University of Rome La Sapienza, Via di Novella, 11, 00199, Rome, Italy
J Crohns Colitis 2:352-6. 2008..Genetic defects in Authophagy-related 16-like gene (ATG16L1) and Immunity-related Guanosine Triphospatase (IRGM) recently found in ileal CD patients lead to a reduction of ..
- The genetic basis of inflammatory bowel diseaseRachel Cooney
Nuffield Department of Medicine, Oxford University, Oxford, UK
Dig Dis 27:428-42. 2009..In particular, the importance of the innate immune system has been reaffirmed with the identification of IRGM and ATG16L1 genes in the autophagy pathway as CD susceptibility genes...
- Eating the enemy in Crohn's disease: an old theory revisitedRenzo Caprilli
University of Rome La Sapienza, Rome, Italy
J Crohns Colitis 4:377-83. 2010..of Crohn's disease came from the existence of polymorphism in NOD2 and autophagy-related susceptibility genes (ATG16L1 and IRGM) in patients and from the identification of the presence of adherent-invasive E...
- Plasma membrane helps autophagosomes growBrinda Ravikumar
Department of Medical Genetics, Cambridge, UK
Autophagy 6:1184-6. 2010..Our study suggests that Atg16L1 interacts with clathrin heavy-chain/AP2 and is also localized on vesicles (positive for clathrin or cholera toxin ..
- Direct link between Atg protein and small GTPase Rab: Atg16L functions as a potential Rab33 effector in mammalsMitsunori Fukuda
Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan
Autophagy 4:824-6. 2008b>Atg16L is a factor that is essential for elongation of the isolation membrane (also called phagophore), a precursor of the autophagosome...
- Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta productionTatsuya Saitoh
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Nature 456:264-8. 2008..Here we show that Atg16L1 (autophagy-related 16-like 1), which is implicated in Crohn's disease, regulates endotoxin-induced inflammasome ..
- IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypesMattia Lauriola
Department of Histology, Embryology and Applied Biology, University of Bologna, I 40126 Bologna, Italy
Int J Mol Med 27:469-77. 2011..domain containing 2 caspase-activation recruitment domain 15 (NOD2/CARD15), autophagy related 16-like 1 (ATG16L1) and paired-like homeobox 2b (PHOX2B) as susceptibility loci for Crohn's Disease (CD)...
- Role of autophagy and autophagy genes in inflammatory bowel diseaseKen Cadwell
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Curr Top Microbiol Immunol 335:141-67. 2009Polymorphisms associated with two genes in the autophagy pathway, ATG16L1 and IRGM1, have been implicated in susceptibility to Crohn's disease, an idiopathic inflammatory disease typically involving the gastrointestinal tract...
- Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?Simone C Wolfkamp
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam
Eur J Gastroenterol Hepatol 22:933-7. 2010Autophagy-related 16-like 1 gene (ATG16L1) and immunity-related guanosine triphosphatase gene (IRGM) are associated with Crohn's disease susceptibility and autophagy. Elimination of invading pathogens is a function of autophagy...
- Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancerP Brest
Inserm ERI 21 EA 4319, Faculty of Medicine, University of Nice Sophia Antipolis, Nice, France
Curr Mol Med 10:486-502. 2010..In 2007, two different autophagy-related genes, ATG16L1 (autophagy-related gene 16-like 1) and IRGM (immunity-related GTPase M) were shown to be specifically involved in ..
- Abnormalities in the handling of intracellular bacteria in Crohn's diseasePierre Lapaquette
Clermont Universite, Clermont Ferrand, France
J Clin Gastroenterol 44:S26-9. 2010..of bacterial cell walls (NOD2/CARD15), and for bacterial clearance and antigen processing through autophagy (ATG16L1 and IRGM)...
- Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteinsEisuke Itakura
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
Autophagy 6:764-76. 2010..Under starvation conditions, ULK1,Atg14, WIPI-1, LC3 and Atg16L1 target to the same compartment, whereas DFCP1 localizes adjacently to these Atgproteins...
- Pediatric inflammatory bowel disease: clinical and molecular geneticsVincent Biank
Department of Pediatrics, Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Inflamm Bowel Dis 13:1430-8. 2007..of several novel susceptibility loci associated with pediatric-onset Crohn's disease such as IL23R and ATG16L1. These genes join the already confirmed IBD susceptibility genes such as NOD2/CARD15, IBD5, and DLG5...
- Abnormalities in the handling of intracellular bacteria in Crohn's disease: a link between infectious etiology and host genetic susceptibilityAnne Lise Glasser
Pathogenie Bacterienne Intestinale, Universite d Auvergne, JE 2526, USC INRA 2018, Clermont Ferrand, France
Arch Immunol Ther Exp (Warsz) 56:237-44. 2008..receptors of bacterial cell walls (NOD2/CARD15) and for bacterial clearance and antigen processing via autophagy (ATG16L1 and IRGM)...
- Genetics of inflammatory bowel disease: clues to pathogenesisHu Zhang
IBD Genetics Research Group, Addenbrooke s Hospital, Cambridge University, UK
Br Med Bull 87:17-30. 2008..Substantial progress has been made in the last 2 years in characterizing the susceptibility genes involved...
- Coordinate regulation of autophagy and apoptosis in T cells by death effectors: FADD or foundationBryan D Bell
Center for Immunology, Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697 3900, USA
Autophagy 5:238-40. 2009..We observed recruitment of FADD, casp8 and serine/threonine kinase RIPK1 to complexes containing Atg5, Atg12 and Atg16L, suggesting that the generation of early autophagosomes leads to the assembly of complexes that activate casp8...
- The genetics of Crohn's diseaseJohan Van Limbergen
Department of Pediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom
Annu Rev Genomics Hum Genet 10:89-116. 2009..TLR4, CARD9), the differentiation of Th17-lymphocytes (IL-23R, JAK2, STAT3, CCR6, ICOSLG), autophagy (ATG16L1, IRGM, LRRK2), maintenance of epithelial barrier integrity (IBD5, DLG5, PTGER4, ITLN1, DMBT1, XBP1), and the ..
- Molecular basis of canonical and bactericidal autophagyTakeshi Noda
Department of Cellular Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
Int Immunol 21:1199-204. 2009..describe the current understanding of three of the basic components of the canonical autophagy machinery-LC3, the Atg16L complex and phosphatidylinositol 3-phosphate (PI3P)-which are dynamically associated with the autophagic structure...
- Inflammatory Bowel Diseases: the genetic revolutionC Jung
Hopital Robert Debre, Service de gastroentérologie et nutrition pédiatriques, 48, boulevard Serurier, 75019 Paris, France
Gastroenterol Clin Biol 33:S123-30. 2009..the past, genome-wide scans allowed finding several susceptibility genes for Crohn disease including NOD2, IL23R, ATG16L1, IRGM, TNFSF15, a region close to PTGER4, PTPN2, PTPN22, NKX2-3 and many others...
- NOD2-mediated autophagy and Crohn diseaseOliver Brain
Translational Gastroenterology Unit, John Radcliffe Hospital, Headington, Oxford, UK
Autophagy 6:412-4. 2010..Our recent study shows NOD2 activates autophagy in a manner requiring ATG16L1, another CD susceptibility gene...
- Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot studyJessica J Lee
Children s Hospital Boston, MA 02115, USA
Ann Hum Genet 74:489-97. 2010..1 intergenic region (rs10761659) and ATG16L1 (rs10210302), in growth-impaired CD children (OR = 2.36, CI [1.26-4.41] p = 0.0056 and OR = 2.45, CI [1.22-4...
- Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagyYoshinori Takahashi
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, USA
Autophagy 7:61-73. 2011..continuous tubulation and fragmentation to produce cytoplasmic punctate structures that are positive for Rab5, Atg16L and LC3...
- A study in three European IBD cohorts confirms that the ATG16L1 c.898A>G (p.Thr300Ala) variant is a susceptibility factor for Crohn's diseaseCarsten Buning
Department of Gastroenterology, Hepatology and Endocrinology, Charite, Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
J Crohns Colitis 1:70-6. 2007A recent study reported that a nonsynonymous SNP rs2241880 (c.898A>G, p.Thr300Ala) within ATG16L1 confers susceptibility to Crohn's disease (CD). We analyzed ATG16L1 c...
- Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reportersJeong Sun Ju
Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue Saint Louis, MO 63110, USA
Autophagy 5:511-9. 2009..This autophagic response in skeletal muscle in vivo was abrogated by co-treatment with chloroquine and in ATG16L1 hypomorphic mice...
- Update on genetics in inflammatory diseaseCasper G Noomen
Department of Gastroenterology and Hepatology, Leiden University Medical Center, C4 12 Leiden, The Netherlands
Best Pract Res Clin Gastroenterol 23:233-43. 2009..gene variants have been identified and replicated, the two most widely replicated being variants in the IL23R and ATG16L1 genes...
- Bacterial invasion: linking autophagy and innate immunityLorenzo Galluzzi
INSERM, U848, F 94805 Villejuif, France Institut Gustave Roussy, F 94805 Villejuif, France
Curr Biol 20:R106-8. 2010..with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity ..
- The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein AlfyMaria Filimonenko
Centre for Cancer Biomedicine, University of Oslo, Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway
Mol Cell 38:265-79. 2010..inclusions and scaffolds a complex between p62(SQSTM1)-positive proteins and the autophagic effectors Atg5, Atg12, Atg16L, and LC3...
- Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseasesDaniel N Frank
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80045, USA
Inflamm Bowel Dis 17:179-84. 2011..We hypothesize that NOD2 and ATG16L1 risk alleles may be associated with these alterations.
- The role of genetics in inflammatory bowel diseaseLiesbet Henckaerts
Department of Gastroenterology University Hospital Gasthuisberg, Leuven, Belgium
Curr Drug Targets 9:361-8. 2008..association studies (WGAS) have now become possible and have identified additional genes (IL23R, IRGM, PTGER4, ATG16L1) for Crohn's disease and ulcerative colitis, that have subsequently been replicated...
- Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel diseaseMarla C Dubinsky
Department of Pediatrics and Medicine, Inflammatory Bowel Disease Program, Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
Inflamm Bowel Dis 16:1357-66. 2010..The aim was to test associations of known IBD susceptibility loci and novel "pharmacogenetic" GWAS identified loci with primary nonresponse to anti-TNFalpha in pediatric IBD patients and develop a predictive model of primary nonresponse...
- Negative regulators in Toll-like receptor responsesShizuo Akira
From the Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
Cornea 29:S13-9. 2010..We recently generated mutant mice lacking Atg16L1, an autophagy-related gene that is implicated in Crohn's disease, and thereby examined its role in TLR-mediated ..
- Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cellsMichael Scharl
Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
Inflamm Bowel Dis 18:1287-302. 2012..tyrosine phosphatase nonreceptor type 2 (PTPN2), and autophagy genes, such as autophagy-related 16-like 1 (ATG16L1), with chronic inflammatory disorders, such as Crohn's disease (CD)...
- Role of genetics in the diagnosis and prognosis of Crohn's diseaseEpameinondas V Tsianos
1st Division of Internal Medicine and Hepato Gastroenterology Unit, Department of Medicine, Medical School, University of Ioannina, Leoforos Stavrou Niarxou, PO Box 1186, 45110 Ioannina, Greece
World J Gastroenterol 18:105-18. 2012..So far, the most strong and replicated associations with Crohn's disease have been done with NOD2, IL23R and ATG16L1 genes...
- NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humansEsmeralda Juarez
Department of Microbiology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
Eur J Immunol 42:880-9. 2012..In addition, the autophagy proteins IRGM, LC3 and ATG16L1 were recruited to the bacteria-containing autophagosome after treatment with MDP...
- Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial compositionEllen Li
Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
PLoS ONE 7:e26284. 2012..These subjects also were genotyped for the three major NOD2 risk alleles (Leu1007fs, R708W, G908R) and the ATG16L1 risk allele (T300A)...
- Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humansDeepa Raju
Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
Autophagy 8:1387-8. 2012..We also determined that the Crohn disease susceptibility polymorphism in the essential autophagy gene ATG16L1 increases susceptibility to H. pylori infection...
- SNP-SNP interactions discovered by logic regression explain Crohn's disease geneticsIrina Dinu
School of Public Health, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 7:e43035. 2012..g., il23r, nod2, cyld, nkx2-3, il12rb2, atg16l1)...
- A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infectionAmanda M Marchiando
Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Cell Host Microbe 14:216-24. 2013Polymorphisms in the essential autophagy gene Atg16L1 have been linked with susceptibility to Crohn's disease, a major type of inflammatory bowel disease (IBD)...
- Association of Egr-1 and autophagy-related gene polymorphism in men with chronic obstructive pulmonary diseaseChiung Zuei Chen
Division of Chest Medicine, Department of Internal Medicine, National Cheng Kung University Hospital, Medical College, National Cheng Kung University, Tainan, Taiwan
J Formos Med Assoc 114:750-5. 2015..been identified: Egr-1 (early growth response), associated with different phenotype expressions in asthma; and, Atg16L1 (autophagy related 16-like 1), a candidate gene responsible for susceptibility to chronic inflammatory diseases...
- Diverse autophagosome membrane sources coalesce in recycling endosomesClaudia Puri
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
Cell 154:1285-99. 2013..traffics from the plasma membrane to recycling endosomes in carriers that appear to be routed differently from ATG16L1-containing vesicles, another source of autophagosome membrane...
- MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagyChangming Lu
Division of Hematology and Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama
Gastroenterology 146:188-99. 2014..of the microRNAs (miRs) MIR106B and MIR93 in induction of autophagy and bacterial clearance in human cell lines and the correlation between MIR106B and autophagy-related gene 16L1 (ATG16L1) expression in tissues from patients with CD.
- Interleukin-1β in innate inflammation, autophagy and immunityLeo A B Joosten
Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
Semin Immunol 25:416-24. 2013..A role for autophagy in production of IL-1β has emerged with deletion of the autophagy gene ATG16L1. Macrophages from ATG16L1-deficient mice produce higher levels of IL-1β after stimulation with TLR4 ligands via ..
- Decoding norovirus infection in Crohn's diseaseMathias Chamaillard
Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France CNRS, UMR 8204, Lille, France Institut National de la Santé et de la Recherche Médicale, U1019, Team 7, Equipe FRM, Lille, France Univ Lille Nord de France, Lille, France and Université Lille 2, Faculte de Medecine, CHRU de Lille, Laboratoire de Virologie EA3610, Loos Lez Lille, France
Inflamm Bowel Dis 20:767-70. 2014..these findings, host variations in additional genes involved in host response to norovirus infection (such as ATG16L1 and NOD2) predispose humans to Crohn's ileitis...
- A CARD9 polymorphism is associated with decreased likelihood of persistent conjugated hyperbilirubinemia in intestinal failureKarolina Maria Burghardt
Group for Improvement of Intestinal Function and Treatment GIFT, Transplant Centre, Toronto, Ontario, Canada Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Toronto, Ontario, Canada
PLoS ONE 9:e85915. 2014..Therefore, we sought to determine if polymorphisms in the NOD2 signaling cascade, including NOD2, CARD9, RAC1 and ATG16L1 are associated with intestinal failure (IF) or its complications...
- Association of autophagy-related 16-like 1 (ATG16L1) gene polymorphism with sepsis severity in patients with sepsis and ventilator-associated pneumoniaA Savva
4th Department of Internal Medicine, Attikon University Hospital, University of Athens, Medical School, 1 Rimini Str, 12462, Athens, Greece
Eur J Clin Microbiol Infect Dis 33:1609-14. 2014..Mechanically ventilated patients with VAP were studied. Genotyping for autophagy-related 16-like 1 (ATG16L1, rs2241880) functional polymorphism was performed using the TaqMan single-nucleotide assay...
- WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1Hannah C Dooley
London Research Institute, Cancer Research UK, 44 Lincolns Inn Fields, London WC2A 3LY, UK
Mol Cell 55:238-52. 2014..By identifying interacting partners of WIPIs, WD-repeat PtdIns(3)P effector proteins, we found that Atg16L1 directly binds WIPI2b...
- The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patientsMehdi Sadaghian Sadabad
Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Gut 64:1546-52. 2015Crohn's disease (CD) is caused by a complex interplay among genetic, microbial and environmental factors. ATG16L1 is an important genetic factor involved in innate immunity, including autophagy and phagocytosis of microbial components ..
- WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1Hannah C Dooley
a London Research Institute Cancer Research UK London, UK
Autophagy 11:190-1. 2015..In a recent study, we reported that WIPI2B directly binds ATG16L1 and functions by recruiting the ATG12-ATG5-ATG16L1 complex to forming autophagosomes during starvation- or ..
- Genetic determinants of quantitative traits associated with cardiovascular disease riskBozena Smolkova
Department of Experimental and Applied Genetics, Slovak Medical University, 83303 Bratislava, Slovakia Electronic address
Mutat Res 778:18-25. 2015..Prior to multiple testing correction, univariate analysis associated APOE rs429358, rs7412 and ATG16L1 rs2241880 variants with serum lipid levels, while LEPR rs1137100 and ATG16L1 rs2241880 variants were linked to ..
- Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel diseaseHiutung Chu
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Science 352:1116-20. 2016..We reveal that OMVs require IBD-associated genes, ATG16L1 and NOD2, to activate a noncanonical autophagy pathway during protection from colitis...
- Association between ATG16L1 gene polymorphism and the risk of Crohn's diseaseBei bei Zhang
Department of Medical Affairs, General Hospital of PLA Chengdu Military Area Command, Chengdu, China
J Int Med Res . 2016To perform a meta-analysis to evaluate studies investigating the association between ATG16L1 gene polymorphism and Crohn's disease.
- Variants in autophagy-related genes and clinical characteristics in melanoma: a population-based studyKirsten A M White
Department of Medicine, Division of Epidemiology, University of New Mexico, Albuquerque, New Mexico
Cancer Med 5:3336-3345. 2016..We examined five single-nucleotide polymorphisms (SNPs) in three ATG genes (ATG5; ATG10; and ATG16L) with known or suspected impact on autophagic flux in an international population-based case-control study of ..
- The genetic background of inflammatory bowel disease: from correlation to causalityWerna Tc Uniken Venema
Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
J Pathol 241:146-158. 2017..We highlight important causal genetic variants in the candidate genes NOD2, ATG16L1, IRGM, IL23R, CARD9, RNF186, and PRDM1...
- Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidationHannah E J Polson
Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
Autophagy 6:506-22. 2010..WIPI2 is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes...
- Functional consequences of mutations in the autophagy genes in the pathogenesis of Crohn's diseaseOliver Brain
TGU, John Radcliffe Hospital, Oxford, UK
Inflamm Bowel Dis 18:778-81. 2012..The associated polymorphisms in ATG16L1 and IRGM have been confirmed, and functional studies have begun to shed light on how they link to CD pathogenesis...
- Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formationMario Mauthe
Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany
Autophagy 7:1448-61. 2011..In line with this, resveratrol did not promote phagophore localization of WIPI-1, WIPI-2 or the Atg16L complex above basal level...
- Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagyEisuke Itakura
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
J Cell Sci 125:1488-99. 2012..Structures containing upstream Atg proteins, including ULK1, Atg14, DFCP1, WIPI-1 and Atg16L1, can associate with depolarized mitochondria even in the absence of membrane-bound LC3...
- Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory responsePierre Lapaquette
Clermont Universite, Universite d Auvergne, UMR Inserm Université d Auvergne U1071, USC INRA 2018, Clermont Ferrand, France
Cell Microbiol 14:791-807. 2012..CD-associated polymorphisms in NOD2, ATG16L1 and IRGM affect bacterial autophagy, a crucial innate immunity mechanism...
- A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugateDandan Chen
Division of Biochemistry, Biophysics, and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Mol Cell 45:629-41. 2012....
- Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's diseaseMaureen J Koslowski
Dr Margarete Fischer Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
PLoS Genet 8:e1002523. 2012..Different ileal CD-associated genes including NOD2, ATG16L1, and recently the β-catenin-dependant Wnt transcription factor TCF7L2 have been linked to impaired PC ..
- Adherent Escherichia coli and associated virulence genes in children with IBDSandra C Kim; Fiscal Year: 2010..Specific aim 2: Determine if polymorphisms of genes that regulate bacterial processing and killing (NOD2, ATG16L1, IRGM) are associated with (a) mucosal colonization in the intestine of AIEC, and (b) increased E...
- MicroRNA-mediated regulation of ATG16L1 expression and autophagyJohn Kwon; Fiscal Year: 2012DESCRIPTION (provided by applicant) ATG16L1 was recently identified in genome-wide association studies as a Crohn's disease susceptibility gene, thereby implicating autophagy in the pathogenesis of Crohn's disease...
- KEN HASHIGIWA CADWELL; Fiscal Year: 2016..b>Atg16L1 and Nod2 are two Crohn's disease susceptibility genes that have received much attention because of their ..
- David Q Shih; Fiscal Year: 2016..identified several IBD associated genes including intracellular pattern recognition sensor NOD2, autophagy genes (ATG16L1 and IRGM) and tumor necrosis factor superfamily member 15 (TNFSF15)...
- Functional consequences of autophagy mutations in Crohn's disease.David L Boone; Fiscal Year: 2012DESCRIPTION (provided by applicant): Genome wide scans (GWS) have implicated two autophagy genes, ATG16L1 and IRGM, in Crohn's disease (CD), thus implicating autophagy in the pathology of CD...
- Effect of Crohn's Disease Risk Alleles on Enteric MicrobiotaEllen Li; Fiscal Year: 2010..Crohn's disease (CD) risk alleles, such as the NOD2 and ATG16L1, have been associated with defective host containment of commensal bacteria...
- Herbert W Virgin; Fiscal Year: 2014..phenotypes in mice carrying a mutation in the Crohn's disease susceptibility-linked autophagy gene Atg16L1. Susceptibility to Crohn's disease, an inflammatory disease involving the ileum, is controlled in part by a ..
- VANESSA MARIE HUBBARD-LUCEY; Fiscal Year: 2014..One of these risk factors, Atg16L1, a gene important for autophagy, has been shown to be critical for IBD development and may influence mortality in ..
- Ramnik J Xavier; Fiscal Year: 2014..Ocean State Crohn's and Colitis Area Registry, an inception cohort in Rhode Island) to enroll subjects with ATG16L1, IRGM, and NOD2 disease-associated variants, as well as healthy individuals with and without these risk alleles...
- ALEXANDRIA K MAURER; Fiscal Year: 2015..Additionally, commensal bacteria in the intestine are thought to contribute to disease. Atg16L1 is an autophagy gene associated with increased susceptibility of developing the inflammatory bowel disease (IBD) ..
- Indira U Mysorekar; Fiscal Year: 2016..We recently showed that an autophagy gene, Atg16L1, plays a key role in UTI pathogenesis: a mutation in the Atg16L1 gene limits the ability of UPEC to persist and ..
- BROC TAYLOR MCCUNE; Fiscal Year: 2015..We will test if Dap1 deficiency protects mice from gastrointestinal pathologies occurring in mice hypomorphic for Atg16L1 after virus infection, determine if Dap1-/- mice are resistant to colitis induced by IL10 deficiencies, and ..
- MACROPHAGE GENE EXPRESSION IN MUCOSAL INFLAMMATIONScott E Plevy; Fiscal Year: 2010..Specifically, the CD susceptibility genes CARD15, ATG16L1, and IRGM all have important roles in host-microbial responses;including sensing of microbial;products, ..
- Jianzhong Hu; Fiscal Year: 2015..Over 70 susceptibility loci, particularly immune response genes such as NOD2/CARD15, IRGM and ATG16L1, have been associated with CD risk in individuals of European ancestry...
- John D Rioux; Fiscal Year: 2016..What is equally clear, although there are some notable exceptions (e.g. IL23R, ATG16L1) GWA studies have not directly led to the causal genes or specific functional variants, and this has greatly ..
- Autophagy and Nod2 Function in Crohn's DiseaseCHRISTINE L MCDONALD; Fiscal Year: 2013..in CD and lead us to propose the following central hypothesis: CD- associated mutations in the autophagy genes, ATG16L1 (autophagy related 16-like protein 1) and IRGM (immunity-related GTPase family, M), and NOD2 impair the same ..
- Ramnik J Xavier; Fiscal Year: 2016..role for autophagy in Crohn's disease (CD)1, revealing a coding polymorphism in the autophagy gene ATG16L1 that is associated with increased risk of CD4...
- Autophagy in TuberculosisVOJO P DERETIC; Fiscal Year: 2011..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
- Mechanism of M. tuberculosis Phagosome Maturation ArrestVojo Deretic; Fiscal Year: 2008..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
- Pseudomonas in Cystic Fibrosis-Regulation of MucoidyVojo Deretic; Fiscal Year: 2006..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
- Hyperacidification and Pseudomonas infections in CFVojo Deretic; Fiscal Year: 2006..abstract_text> ..
- Identifying Disease Variants for Familial Crohns DiseaseSteven R Brant; Fiscal Year: 2010..With this study, we will test 9000 gene markers in these regions and identify the specific genes and, by gene sequencing, the specific DNA abnormalities that result in a significant proportion of familial Crohn's disease. ..
- Mapping Chromosome 3q Inflammatory Bowel Disease GenesJUDY CHO; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Spondyloarthritis 2006; The Unmet NeedsJohn Reveille; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Crohn's Disease Gene Mapping of Chromosome 16STEVEN BRANT; Fiscal Year: 2005..Defining the IBD1 mutation for CD will be a major step in unraveling the etiology and pathophysiology of this enigmatic disease, improve genetic counseling and make possible novel preventative and therapeutic strategies. ..
- IDENTIFYING MAJOR SUSCEPTIBILITY GENES OF IBDJUDY CHO; Fiscal Year: 2003..Once risk alleles are identified in multiplex families, characterization of the nature and broad significance of specific risk alleles for IBD in a variety of populations will be performed. ..
- FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITISJohn Reveille; Fiscal Year: 2003..abstract_text> ..
- Mycobacterium avium subspecies in Crohn's DiseaseSaleh Naser; Fiscal Year: 2005..Ultimately, the outcome of this study will go a long way toward clearing up the MAP debate. ..