ATM

Summary

Gene Symbol: ATM
Description: ATM serine/threonine kinase
Alias: AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, serine-protein kinase ATM, A-T mutated, AT mutated, TEL1, telomere maintenance 1, homolog, ataxia telangiectasia mutated
Species: human
Products:     ATM

Top Publications

  1. Hinz M, Stilmann M, Arslan S, Khanna K, Dittmar G, Scheidereit C. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Mol Cell. 2010;40:63-74 pubmed publisher
    ..The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and the kinase ataxia telangiectasia mutated (ATM) act as proximal signal mediators...
  2. Choi S, Srivas R, Fu K, Hood B, Dost B, Gibson G, et al. Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes. J Proteome Res. 2012;11:4983-91 pubmed publisher
    b>ATM is a protein kinase that initiates a well-characterized signaling cascade in cells exposed to ionizing radiation (IR)...
  3. Gamper A, Choi S, Matsumoto Y, Banerjee D, Tomkinson A, Bakkenist C. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. J Biol Chem. 2012;287:12445-54 pubmed publisher
    ..with a characteristic hypersensitivity to ionizing radiation that is caused by biallelic mutations in A-T mutated (ATM), a gene encoding a protein kinase critical for the induction of cellular responses to DNA damage, particularly to ..
  4. Taneichi D, Iijima K, Doi A, Koyama T, Minemoto Y, Tokunaga K, et al. Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 1. J Neuroimmune Pharmacol. 2011;6:177-87 pubmed publisher
    ..Consistently, Vpr-induced DSBs were attenuated by extensive downregulaion of endogenous SNF2h. Based on these data, we discuss the role of DSB and DSB signals in the viral infection. ..
  5. Zhou K, Bellenguez C, Spencer C, Bennett A, Coleman R, Tavendale R, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet. 2011;43:117-20 pubmed publisher
    ..9 × 10(-9), odds ratio = 1.35, 95% CI 1.22-1.49) at a locus containing ATM, the ataxia telangiectasia mutated gene...
  6. Rose Zerilli M, Forster J, Parker H, Parker A, Rodríguez A, Chaplin T, et al. ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial. Haematologica. 2014;99:736-42 pubmed publisher
    b>ATM mutation and BIRC3 deletion and/or mutation have independently been shown to have prognostic significance in chronic lymphocytic leukemia...
  7. Lee A, Chiba T, Truong L, Cheng A, Do J, Cho M, et al. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J Biol Chem. 2012;287:2531-43 pubmed publisher
    ..We demonstrated that ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) proteins directly phosphorylate Dbf4 in ..
  8. Song L, Lin C, Wu Z, Gong H, Zeng Y, Wu J, et al. miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase. PLoS ONE. 2011;6:e25454 pubmed publisher
    ..b>Ataxia Telangiectasia Mutated (ATM) Kinase, which functions as the primary sensor and transducer of DNA damage signal, has been ..
  9. Verhagen M, Last J, Hogervorst F, Smeets D, Roeleveld N, Verheijen F, et al. Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: a genotype-phenotype study. Hum Mutat. 2012;33:561-71 pubmed publisher
    ..disorder with multisystem involvement and cancer predisposition, caused by mutations in the A-T mutated (ATM) gene...
  10. Norman J, Mashiba M, McNamara L, Onafuwa Nuga A, Chiari Fort E, Shen W, et al. The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells. Nat Immunol. 2011;12:975-83 pubmed publisher
    ..Our results show that pathogen-induced deamination of cytidine and the DNA-damage response to virus-mediated repair of the incorporation of uridine enhance the recognition of HIV-infected cells by NK cells. ..

Detail Information

Publications62

  1. Hinz M, Stilmann M, Arslan S, Khanna K, Dittmar G, Scheidereit C. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Mol Cell. 2010;40:63-74 pubmed publisher
    ..The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and the kinase ataxia telangiectasia mutated (ATM) act as proximal signal mediators...
  2. Choi S, Srivas R, Fu K, Hood B, Dost B, Gibson G, et al. Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes. J Proteome Res. 2012;11:4983-91 pubmed publisher
    b>ATM is a protein kinase that initiates a well-characterized signaling cascade in cells exposed to ionizing radiation (IR)...
  3. Gamper A, Choi S, Matsumoto Y, Banerjee D, Tomkinson A, Bakkenist C. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. J Biol Chem. 2012;287:12445-54 pubmed publisher
    ..with a characteristic hypersensitivity to ionizing radiation that is caused by biallelic mutations in A-T mutated (ATM), a gene encoding a protein kinase critical for the induction of cellular responses to DNA damage, particularly to ..
  4. Taneichi D, Iijima K, Doi A, Koyama T, Minemoto Y, Tokunaga K, et al. Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 1. J Neuroimmune Pharmacol. 2011;6:177-87 pubmed publisher
    ..Consistently, Vpr-induced DSBs were attenuated by extensive downregulaion of endogenous SNF2h. Based on these data, we discuss the role of DSB and DSB signals in the viral infection. ..
  5. Zhou K, Bellenguez C, Spencer C, Bennett A, Coleman R, Tavendale R, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet. 2011;43:117-20 pubmed publisher
    ..9 × 10(-9), odds ratio = 1.35, 95% CI 1.22-1.49) at a locus containing ATM, the ataxia telangiectasia mutated gene...
  6. Rose Zerilli M, Forster J, Parker H, Parker A, Rodríguez A, Chaplin T, et al. ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial. Haematologica. 2014;99:736-42 pubmed publisher
    b>ATM mutation and BIRC3 deletion and/or mutation have independently been shown to have prognostic significance in chronic lymphocytic leukemia...
  7. Lee A, Chiba T, Truong L, Cheng A, Do J, Cho M, et al. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J Biol Chem. 2012;287:2531-43 pubmed publisher
    ..We demonstrated that ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) proteins directly phosphorylate Dbf4 in ..
  8. Song L, Lin C, Wu Z, Gong H, Zeng Y, Wu J, et al. miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase. PLoS ONE. 2011;6:e25454 pubmed publisher
    ..b>Ataxia Telangiectasia Mutated (ATM) Kinase, which functions as the primary sensor and transducer of DNA damage signal, has been ..
  9. Verhagen M, Last J, Hogervorst F, Smeets D, Roeleveld N, Verheijen F, et al. Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: a genotype-phenotype study. Hum Mutat. 2012;33:561-71 pubmed publisher
    ..disorder with multisystem involvement and cancer predisposition, caused by mutations in the A-T mutated (ATM) gene...
  10. Norman J, Mashiba M, McNamara L, Onafuwa Nuga A, Chiari Fort E, Shen W, et al. The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells. Nat Immunol. 2011;12:975-83 pubmed publisher
    ..Our results show that pathogen-induced deamination of cytidine and the DNA-damage response to virus-mediated repair of the incorporation of uridine enhance the recognition of HIV-infected cells by NK cells. ..
  11. Gatei M, Jakob B, Chen P, Kijas A, Becherel O, Gueven N, et al. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J Biol Chem. 2011;286:31542-56 pubmed publisher
    ..the recent description of a patient with Rad50 deficiency characterized by chromosomal instability and defective ATM-dependent signaling...
  12. Woodbine L, Brunton H, Goodarzi A, Shibata A, Jeggo P. Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. Nucleic Acids Res. 2011;39:6986-97 pubmed publisher
    Ataxia telangiectasia (ATM) mutated and Artemis, the proteins defective in ataxia telangiectasia and a class of Radiosensitive-Severe Combined Immunodeficiency (RS-SCID), respectively, function in the repair of DNA double strand breaks (..
  13. Li J, Hart R, Mallimo E, Swerdel M, Kusnecov A, Herrup K. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci. 2013;16:1745-53 pubmed publisher
    The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency...
  14. Zhou Y, Paull T. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J Biol Chem. 2013;288:37112-25 pubmed publisher
    ..This work suggests that, in addition to its key role in nonhomologous end joining, DNA-PKcs also acts in concert with MRN and ataxia telangiectasia-mutated to regulate resection and thus DNA repair pathway choice. ..
  15. Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, et al. DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 2012;3:1026-35 pubmed
    ..Consistent with previous studies, we found that inactivation of the Ataxia Telangiectasia Mutated (ATM) kinase, in turn, impaired DNA damage-induced Mdm2 destruction...
  16. Squatrito M, Brennan C, Helmy K, Huse J, Petrini J, Holland E. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell. 2010;18:619-29 pubmed publisher
    ..encoding components of the DDR pathway are frequently altered in human gliomas and that loss of elements of the ATM/Chk2/p53 cascade accelerates tumor formation in a glioma mouse model...
  17. Roossink F, Wieringa H, Noordhuis M, ten Hoor K, Kok M, Slagter Menkema L, et al. The role of ATM and 53BP1 as predictive markers in cervical cancer. Int J Cancer. 2012;131:2056-66 pubmed publisher
    ..In a panel of cervical cancer cell lines, inactivation of ataxia telangiectasia mutated (ATM) or its substrate p53-binding protein-1 (53BP1) clearly gave rise to cell cycle defects in ..
  18. Wang C, Wu K, Yang Y, Peng C, Tsai F, Lin D, et al. Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan. Chin J Physiol. 2011;54:413-8 pubmed publisher
    The ataxia telangiectasia mutated (ATM) gene plays a major role in repairing the double-strand breaks and maintaining the genome stability...
  19. Smith J, Tho L, Xu N, Gillespie D. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res. 2010;108:73-112 pubmed publisher
    ..Cellular responses to DNA damage are coordinated primarily by two distinct kinase signaling cascades, the ATM-Chk2 and ATR-Chk1 pathways, which are activated by DNA double-strand breaks (DSBs) and single-stranded DNA ..
  20. Cam H, Easton J, High A, Houghton P. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell. 2010;40:509-20 pubmed publisher
    ..Here we show that hypoxia results in ataxia telangiectasia mutated (ATM)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (HIF-1α) on serine(696) and ..
  21. Wood L, Sankar S, Reed R, Haas A, Liu L, MCKINNON P, et al. A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway. PLoS ONE. 2011;6:e16422 pubmed publisher
    Ataxia Telangiectasia (A-T) is an inherited immunodeficiency disorder wherein mutation of the ATM kinase is responsible for the A-T pathogenesis...
  22. Khalil A, Morgan R, Adams B, Golding S, Dever S, Rosenberg E, et al. ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle. 2011;10:481-91 pubmed
    ..2 - 20 Gy, as determined by pulsed-field gel electrophoresis, and accompanied by dose-dependent ATM (ser-1981), H2AX (ser-139), Chk2 (thr-68), and p53 (ser-15) phosphorylation...
  23. Sowd G, Li N, Fanning E. ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication. PLoS Pathog. 2013;9:e1003283 pubmed publisher
    Mutation of DNA damage checkpoint signaling kinases ataxia telangiectasia-mutated (ATM) or ATM- and Rad3-related (ATR) results in genomic instability disorders...
  24. Daniel J, Pellegrini M, Lee B, Guo Z, Filsuf D, Belkina N, et al. Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol. 2012;198:295-304 pubmed publisher
    Ataxia telangiectasia (A-T) mutated (ATM) is a key deoxyribonucleic acid (DNA) damage signaling kinase that regulates DNA repair, cell cycle checkpoints, and apoptosis...
  25. Cosentino C, Grieco D, Costanzo V. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J. 2011;30:546-55 pubmed publisher
    Ataxia telangiectasia (A-T) is a human disease caused by ATM deficiency characterized among other symptoms by radiosensitivity, cancer, sterility, immunodeficiency and neurological defects...
  26. Lin K, Adamson J, Johnson G, Carter A, Oates M, Wade R, et al. Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial: blockade at the level of p21 is associated with short response duration. Clin Cancer Res. 2012;18:4191-200 pubmed publisher
    This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline ..
  27. Nakamura K, Du L, Tunuguntla R, Fike F, Cavalieri S, Morio T, et al. Functional characterization and targeted correction of ATM mutations identified in Japanese patients with ataxia-telangiectasia. Hum Mutat. 2012;33:198-208 pubmed publisher
    ..We studied ATM mutations in eight families of Japanese A-T patients (JPAT) and were able to identify all 16 mutations...
  28. Salimi M, Mozdarani H, Majidzadeh K. Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients. Med Oncol. 2012;29:1502-9 pubmed publisher
    b>ATM protein kinase plays a critical role in maintaining genome integrity by activating a biochemical chain reaction that in turn leads to cell cycle checkpoint activation and repair of DNA damage...
  29. Goetz E, Shankar B, Zou Y, Morales J, Luo X, Araki S, et al. ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. Oncogene. 2011;30:3745-54 pubmed publisher
    ..Here, we show that activation of Ataxia telangiectasia-mutated kinase (ATM) by endogenous or exogenous forms of DNA damage was required to relieve basal repression of IGF-1 transcription by ..
  30. Moyal L, Lerenthal Y, Gana Weisz M, Mass G, So S, Wang S, et al. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell. 2011;41:529-42 pubmed publisher
    The cellular response to DNA double-strand breaks (DSBs) is mobilized by the protein kinase ATM, which phosphorylates key players in the DNA damage response (DDR) network. A major question is how ATM controls DSB repair...
  31. Jiang M, Zhao L, Gamez M, Imperiale M. Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection. PLoS Pathog. 2012;8:e1002898 pubmed publisher
    ..Our results showed that both the ataxia-telangiectasia mutated (ATM)- and ATM and Rad-3-related (ATR)-mediated DDR were activated during BKPyV infection, accompanied by the ..
  32. Guo Z, Kozlov S, Lavin M, Person M, Paull T. ATM activation by oxidative stress. Science. 2010;330:517-21 pubmed publisher
    The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and orchestrates signaling cascades that initiate the DNA damage response...
  33. Yamamoto K, Wang Y, Jiang W, Liu X, Dubois R, Lin C, et al. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol. 2012;198:305-13 pubmed publisher
    Ataxia telangiectasia (A-T) mutated (ATM) kinase orchestrates deoxyribonucleic acid (DNA) damage responses by phosphorylating numerous substrates implicated in DNA repair and cell cycle checkpoint activation...
  34. Wu C, Dong Y, Liang Q, He X, Ng S, Chan F, et al. MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. PLoS ONE. 2013;8:e57036 pubmed publisher
    ..0001). Through in silico search, the 3'UTR of Ataxia telangiectasia mutated (ATM) contains a conserved miR-18a binding site...