ATM

Summary

Gene Symbol: ATM
Description: ATM serine/threonine kinase
Alias: AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, serine-protein kinase ATM, A-T mutated, AT mutated, TEL1, telomere maintenance 1, homolog, ataxia telangiectasia mutated
Species: human

Top Publications

  1. doi The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    Joanne Smith
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Adv Cancer Res 108:73-112. 2010
  2. ncbi DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    Christopher J Bakkenist
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nature 421:499-506. 2003
  3. pmc ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    Angela Alexander
    Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 107:4153-8. 2010
  4. pmc Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    Francis Rodier
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Nat Cell Biol 11:973-9. 2009
  5. ncbi A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    T T Paull
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Curr Biol 10:886-95. 2000
  6. pmc ATM mutations in patients with hereditary pancreatic cancer
    Nicholas J Roberts
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
    Cancer Discov 2:41-6. 2012
  7. pmc The combined status of ATM and p53 link tumor development with therapeutic response
    Hai Jiang
    The Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 23:1895-909. 2009
  8. ncbi Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    S Matsuoka
    Howard Hughes Medical Institute, Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 282:1893-7. 1998
  9. pmc The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    S Y Shieh
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genes Dev 14:289-300. 2000
  10. pmc HIV-1 Vpr: mechanisms of G2 arrest and apoptosis
    Joshua L Andersen
    Center for the Study of Aging and Human Development, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Exp Mol Pathol 85:2-10. 2008

Research Grants

  1. Tahir Hussain; Fiscal Year: 2016
  2. Brain specific non-AT1, non-AT2 angiotensin binding site
    ROBERT CHARLES SPETH; Fiscal Year: 2010
  3. Mohammad Asghar; Fiscal Year: 2015
  4. Role of angiotensin II receptor signaling pathways in body fluid homeostasis
    Derek Daniels; Fiscal Year: 2013
  5. Horng H Chen; Fiscal Year: 2016
  6. Mark R Plummer; Fiscal Year: 2014
  7. JASON MARK BECKTA; Fiscal Year: 2014
  8. Peter J McKinnon; Fiscal Year: 2016
  9. Barry P Sleckman; Fiscal Year: 2016
  10. Tej K Pandita; Fiscal Year: 2014

Detail Information

Publications461 found, 100 shown here

  1. doi The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    Joanne Smith
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Adv Cancer Res 108:73-112. 2010
    ..Cellular responses to DNA damage are coordinated primarily by two distinct kinase signaling cascades, the ATM-Chk2 and ATR-Chk1 pathways, which are activated by DNA double-strand breaks (DSBs) and single-stranded DNA ..
  2. ncbi DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    Christopher J Bakkenist
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nature 421:499-506. 2003
    The ATM protein kinase, mutations of which are associated with the human disease ataxia-telangiectasia, mediates responses to ionizing radiation in mammalian cells...
  3. pmc ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    Angela Alexander
    Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 107:4153-8. 2010
    Ataxia-telangiectasia mutated (ATM) is a cellular damage sensor that coordinates the cell cycle with damage-response checkpoints and DNA repair to preserve genomic integrity...
  4. pmc Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    Francis Rodier
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Nat Cell Biol 11:973-9. 2009
    ..Initiation and maintenance of this cytokine response required the DDR proteins ATM, NBS1 and CHK2, but not the cell-cycle arrest enforcers p53 and pRb...
  5. ncbi A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    T T Paull
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Curr Biol 10:886-95. 2000
    ..Recently it has been reported that a member of the histone H2A family, H2AX, becomes extensively phosphorylated within 1-3 minutes of DNA damage and forms foci at break sites...
  6. pmc ATM mutations in patients with hereditary pancreatic cancer
    Nicholas J Roberts
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
    Cancer Discov 2:41-6. 2012
    ..including whole-genome and whole-exome analyses, and identified heterozygous, constitutional, ataxia telangiectasia mutated (ATM) gene mutations in 2 kindreds with familial pancreatic cancer...
  7. pmc The combined status of ATM and p53 link tumor development with therapeutic response
    Hai Jiang
    The Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 23:1895-909. 2009
    ..Specifically, evaluation of the combined status of ATM and p53, two commonly mutated tumor suppressor genes, can help to predict the clinical response to genotoxic ..
  8. ncbi Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    S Matsuoka
    Howard Hughes Medical Institute, Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 282:1893-7. 1998
    ..activated in response to replication blocks and DNA damage; the response to DNA damage occurred in an ataxia telangiectasia mutated (ATM)-dependent manner...
  9. pmc The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    S Y Shieh
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genes Dev 14:289-300. 2000
    ....
  10. pmc HIV-1 Vpr: mechanisms of G2 arrest and apoptosis
    Joshua L Andersen
    Center for the Study of Aging and Human Development, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Exp Mol Pathol 85:2-10. 2008
    ..Expression of Vpr, in particular, leads to cell cycle arrest in G(2), followed by apoptosis. Here we summarize our current understanding of Vpr biology with a focus on Vpr-induced G(2) arrest and apoptosis...
  11. pmc Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
    Emma Bolderson
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nucleic Acids Res 38:1821-31. 2010
    ..Interestingly, the phosphorylation of Exo1 by ATM appears to regulate the activity of Exo1 following resection, allowing optimal Rad51 loading and the completion of ..
  12. pmc Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks
    Lilach Moyal
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell 41:529-42. 2011
    The cellular response to DNA double-strand breaks (DSBs) is mobilized by the protein kinase ATM, which phosphorylates key players in the DNA damage response (DDR) network. A major question is how ATM controls DSB repair...
  13. doi The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope
    J L Perfettini
    INSERM U848, Institut Gustave Roussy, Universite Paris Sud, Paris 11, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Cell Death Differ 16:298-311. 2009
    ..we demonstrated that, in Env-elicited syncytia, PML was required for activating phosphorylation of ataxia telangiectasia mutated (ATM), which colocalized with PML in nuclear bodies, in a molecular complex that also involved ..
  14. doi A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell 40:63-74. 2010
    ..The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and the kinase ataxia telangiectasia mutated (ATM) act as proximal signal mediators...
  15. pmc ATM is down-regulated by N-Myc-regulated microRNA-421
    Hailiang Hu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:1506-11. 2010
    Ataxia-telangiectasia mutated (ATM) is a high molecular weight protein serine/threonine kinase that plays a central role in the maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair of DNA double-..
  16. ncbi ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma
    Kirsten Grønbaek
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Blood 100:1430-7. 2002
    The ATM serine-threonine kinase plays a central role in the cellular response to DNA damage...
  17. ncbi ATM and related protein kinases: safeguarding genome integrity
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Cancer 3:155-68. 2003
    ..A prime example is the cellular response to DNA double-strand breaks, which activate the ATM protein kinase that, in turn, modulates numerous signalling pathways...
  18. ncbi Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts
    Kazuhito Naka
    Department of Geriatric Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu 474 8522, Japan
    J Biol Chem 279:2030-7. 2004
    ..b>ATM, the product of the gene mutated in individuals with ataxia telangiectasia (AT), plays a central role in cell cycle ..
  19. ncbi 53BP1, an activator of ATM in response to DNA damage
    Tamara A Mochan
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 4268, USA
    DNA Repair (Amst) 3:945-52. 2004
    ..a mediator of DNA DSB signaling, but now it has been shown to function upstream of ataxia-telangiectasia mutated (ATM), in one of at least two parallel pathways leading to ATM activation in response to DNA damage...
  20. pmc Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes
    Alicja Dabrowska
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:8460-77. 2008
    ..The induction of Egr1 and FOXO3a and its target genes was observed in Jurkat cells transduced by Tat alone. Tat-dependent activation of the Egr1-PTEN-FOXO3a pathway provides a mechanism for HIV-1-associated CD4(+) T cell death...
  21. doi A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage
    Luigi Carlessi
    Dept of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Biochim Biophys Acta 1803:1213-23. 2010
    The checkpoint kinase Chk2 is an effector component of the ATM-dependent DNA damage response (DDR) pathway. The activation of Chk2 by genotoxic stress involves its phosphorylation on T68 by ATM and additional auto/transphosphorylations...
  22. pmc A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
    Yingli Sun
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13182-7. 2005
    The ataxia telangiectasia mutant (ATM) protein kinase regulates the cell's response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair...
  23. doi Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: a genotype-phenotype study
    Mijke M M Verhagen
    Department of Pediatric Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Hum Mutat 33:561-71. 2012
    ..disorder with multisystem involvement and cancer predisposition, caused by mutations in the A-T mutated (ATM) gene...
  24. ncbi Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma
    Peilin Zhang
    Department of Pathology, West Virginia University Health Sciences Center, Morgontown, West Virginia 26506 9203, USA
    Cancer Biol Ther 2:87-91. 2003
    ..We report here that there is a high frequency of association of rhabdomyosarcoma with ataxia telangiectasia mutated (ATM) gene mutation/deletion...
  25. ncbi Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A
    Young Joo Jang
    Laboratory of Biochemistry, The School of Dentistry, Dankook University, 29 Anseo Dong, Cheonan, 330 714, Korea
    J Biol Chem 282:2473-82. 2007
    ..Normally, ataxia telangiectasia-mutated kinase (ATM) is a key enzyme involved in G2 phase cell cycle arrest following DNA damage, and inhibition of Plk1 by DNA damage ..
  26. pmc Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)
    Laura A Lindsey-Boltz
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    J Biol Chem 286:19229-36. 2011
    ..Together, these findings indicate that crowding of checkpoint mediator proteins on DNA is sufficient to activate the ATR kinase...
  27. pmc Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
    S Matsuoka
    Howard Hughes Medical Institute, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:10389-94. 2000
    ..Phosphorylation and activation of Chk2 are ataxia telangiectasia-mutated (ATM) dependent in response to IR, whereas Chk2 phosphorylation is ATM-independent when cells are exposed to UV or HU...
  28. doi ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    Aaron A Goodarzi
    Genome Damage and Stability Centre, University of Sussex, East Sussex BN1 9RQ, UK
    Mol Cell 31:167-77. 2008
    b>Ataxia Telangiectasia Mutated (ATM) signaling is essential for the repair of a subset of DNA double-strand breaks (DSBs); however, its precise role is unclear...
  29. ncbi ATR regulates fragile site stability
    Anne M Casper
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 111:779-89. 2002
    ..We demonstrate that the replication checkpoint kinase ATR, but not ATM, is critical for maintenance of fragile site stability...
  30. ncbi Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia
    C Schaffner
    Abteilung Organisation komplexer Genome, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Blood 94:748-53. 1999
    ..The minimal consensus deletion comprises a segment, which contains the ATM gene presenting an interesting candidate gene, as mutations in ATM predispose A-T patients to lymphoid malignancies...
  31. ncbi Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
    K Suzuki
    Laboratory of Radiation and Life Science, School of Pharmaceutical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Biol Chem 274:25571-5. 1999
    The product of the ATM gene, which is mutated in ataxia telangiectasia, is a nuclear phosphoprotein, and it involves the activation of the p53 pathway after ionizing radiation...
  32. ncbi Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity
    Kanaklata Roy
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Biochem Biophys Res Commun 344:821-6. 2006
    Glioblastomas are among the malignancies most resistant to radiation therapy. In contrast, cells lacking the ATM protein are highly sensitive to ionizing radiation...
  33. pmc Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1
    Young C Shin
    Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Virol 80:2257-66. 2006
    Infected cells recognize viral replication as a DNA damage stress and elicit the ataxia telangiectasia-mutated (ATM)/p53-mediated DNA damage response signal transduction pathway as part of the host surveillance mechanisms, which ..
  34. pmc Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes
    T Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Cell Prolif 40:1-13. 2007
    ..The aim of this study was to seek further evidence in support of this postulate, namely to test whether the levels of CAA and CHP correlate with cells metabolic activity...
  35. pmc hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress
    S C Gehen
    Department of Environmental Medicine, The University of Rochester, Rochester, NY 14642, USA
    Oncogene 27:4065-74. 2008
    ..Previous work showed that the PIKK ataxia telangiectasia mutated (ATM) but not ATM and Rad3 related phosphorylates p53 (Ser15) during hyperoxia, a model of prolonged ..
  36. ncbi A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints
    Jung Jung Mu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:17330-4. 2007
    b>ATM (ataxia telangiectasia-mutated) and ATR (ATM-Rad3-related) are proximal checkpoint kinases that regulate DNA damage response (DDR). Identification and characterization of ATM/ATR substrates hold the keys for the understanding of DDR...
  37. ncbi Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
    Xu Li
    Department of Molecular and Clinical Pharmacology, City of Hope, Duarte, California 91010, USA
    J Biol Chem 282:36177-89. 2007
    ..Here, we show that doxorubicin (Dox) treatment induces KAP1 phosphorylation at Ser-824 via an ataxia telangiectasia mutated (ATM)-dependent manner, correlating with the transcriptional de-repression of p21WAF1/CIP1 and ..
  38. ncbi ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity
    Elisa Oricchio
    Institute of Biology and Molecular Pathology, National Research Council, Rome, Italy
    Cell Cycle 5:88-92. 2006
    We previously showed that ATM is responsible for p53 phosphorylation at Ser15 and localization at centrosomes during mitosis...
  39. doi Detection of ATM gene mutations in young lung cancer patients: a population-based control study
    Joachim Schneider
    Institut und Poliklinik für Arbeits und Sozialmedizin der Justus Liebig Universität Giessen, Aulweg, Giessen, Germany
    Arch Med Res 39:226-31. 2008
    ..We initiated a study to elucidate the frequency and clinical relevance of ATM gene mutations in lung cancer patients of the young (LUCY) and compared the results with population-based control ..
  40. doi Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial: blockade at the level of p21 is associated with short response duration
    Ke Lin
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
    Clin Cancer Res 18:4191-200. 2012
    This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline ..
  41. pmc DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM)
    Yi Zhou
    From the Howard Hughes Medical Institute, Department of Molecular Biosciences, and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712
    J Biol Chem 288:37112-25. 2013
    ..This work suggests that, in addition to its key role in nonhomologous end joining, DNA-PKcs also acts in concert with MRN and ataxia telangiectasia-mutated to regulate resection and thus DNA repair pathway choice. ..
  42. ncbi Role for ATM in DNA damage-induced phosphorylation of BRCA1
    M Gatei
    Queensland Institute of Medical Research, The University of Queensland, Royal Brisbane Hospital, Australia
    Cancer Res 60:3299-304. 2000
    ..The gene product [ataxia-telangiectasia mutation (ATM)] mutated in this syndrome is a component of the DNA damage detection pathway...
  43. ncbi Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks
    Ismail Hassan Ismail
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 280:4649-55. 2005
    The protein kinase ataxia telangiectasia mutated (ATM) is activated when cells are exposed to ionizing radiation (IR)...
  44. doi ATM polymorphisms and risk of lung cancer among never smokers
    Yen Li Lo
    Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan
    Lung Cancer 69:148-54. 2010
    The ataxia-telangiectasia mutated (ATM) gene, an important caretaker of overall genome stability, is thought to play a role in the development of human malignancy...
  45. pmc BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    Y Wang
    Verna and Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 14:927-39. 2000
    ..This complex includes tumor suppressors and DNA damage repair proteins MSH2, MSH6, MLH1, ATM, BLM, and the RAD50-MRE11-NBS1 protein complex...
  46. pmc Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function
    Yasuo Ariumi
    Department of Microbiology and Molecular Medicine, University of Geneva, Switzerland
    J Virol 80:2445-52. 2006
    The ataxia-telangiectasia-mutated (ATM) kinase plays a central role in responses to various forms of DNA damage and has been suggested to facilitate human immunodeficiency virus type 1 (HIV-1) integration...
  47. pmc Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
    Sairei So
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Cell Biol 187:977-90. 2009
    b>Ataxia telangiectasia mutated (ATM) plays a critical role in the cellular response to DNA damage. In response to DNA double-strand breaks (DSBs), ATM is autophosphorylated at serine 1981...
  48. pmc Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants
    Bret R Adams
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA
    PLoS ONE 5:e10001. 2010
    ..Importantly, the ATM kinase was shown to be critical for foci formation in astrocytes, but not in hESCs, suggesting that the DDR is ..
  49. ncbi Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females
    Hwei Chung Wang
    Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, ROC
    Anticancer Res 30:5217-21. 2010
    Several epidemiological studies have investigated the association between ataxia telangiectasia mutated (ATM) gene polymorphisms and breast cancer risk...
  50. pmc Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia
    Jiali Li
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, Piscataway, New Jersey 08854, USA
    J Neurosci 31:7568-77. 2011
    The gene that is mutated in ataxia-telangiectasia (A-T), ATM, is catalytically activated in response to DNA damage. Yet a full accounting for the CNS deficits in human A-T or its mouse models remains elusive...
  51. pmc Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection
    Mengxi Jiang
    Department of Microbiology and Immunology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Pathog 8:e1002898. 2012
    ..Our results showed that both the ataxia-telangiectasia mutated (ATM)- and ATM and Rad-3-related (ATR)-mediated DDR were activated during BKPyV infection, accompanied by the ..
  52. ncbi Contributions of ATM mutations to familial breast and ovarian cancer
    Yvonne R Thorstenson
    Stanford Genome Technology Center, Palo Alto, California 94304 1103, USA
    Cancer Res 63:3325-33. 2003
    This study addresses the prevalence of ATM mutations and the association with breast cancer in Austrian families selected for a history of breast or ovarian cancer or both [hereditary breast and ovarian cancer (HBOC)]...
  53. ncbi A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
    Enriqueta Riballo
    Genome Damage and Stability Centre, University of Sussex, East Sussex, BN1 9RQ, United Kingdom
    Mol Cell 16:715-24. 2004
    ..By epistasis analysis, we show that ataxia telangiectasia mutated protein (ATM) and Artemis, the protein defective in patients with RS-SCID, function in a common double-..
  54. ncbi Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity
    Jason S White
    Department of Radiation Oncology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburgh, Pennsylvania, USA
    Cell Cycle 7:1277-84. 2008
    Mutations in the ATM kinase cause the neurodegenerative disorder ataxia telangiectasia (A-T) and affected individuals are exquisitely radiation-sensitive and cancer-prone...
  55. pmc ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells
    Bradley A Stohr
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 2200, USA
    Cancer Res 68:5309-17. 2008
    ..Here, we show that the ataxia-telangiectasia mutated (ATM) protein is activated and forms telomeric foci in response to MT-hTer-47A expression...
  56. ncbi Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line
    Wan Ju Kim
    Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, Louisiana State University, New Orleans, LA 70112, USA
    Oncogene 21:3864-71. 2002
    ..This increased sensitivity to ionizing radiation correlates with lowered levels of ATM expression in HCT-116...
  57. pmc Mantle cell lymphoma is characterized by inactivation of the ATM gene
    C Schaffner
    Abteilung Organisation komplexer Genome, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 97:2773-8. 2000
    ..The deleted segment contains the ATM (ataxia telangiectasia mutated) gene...
  58. pmc Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response
    Chandtip Chandhasin
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:6952-61. 2008
    ..Premature attenuation of ATM kinase activity and reduced association of MDC1 with repair foci were observed in Tax-expressing cells...
  59. pmc Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer
    Sean V Tavtigian
    International Agency for Research on Cancer, 69372 Lyon, France
    Am J Hum Genet 85:427-46. 2009
    The susceptibility gene for ataxia telangiectasia, ATM, is also an intermediate-risk breast-cancer-susceptibility gene...
  60. pmc Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis
    Jean Philip Truman
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 280:23262-72. 2005
    ..59, 5194-5201). Here, we show that TPA functions to decrease the cellular level of the ATM (ataxia telangiectasia mutated) protein, known to repress CS activation (Liao, W.-C., Haimovitz-Friedman, A., Persaud, R...
  61. pmc Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survival
    Rajaneesh Anupam
    Center for Retrovirus Research, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:7661-8. 2011
    ..Our data indicate that p30 specifically binds to cellular ATM (ataxia telangiectasia mutated) and REGγ (a nuclear 20 S proteasome activator)...
  62. ncbi The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways
    Robert T Abraham
    Program in Signal Transduction Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92130, USA
    DNA Repair (Amst) 3:919-25. 2004
    ..The protein kinase activity of hSMG-1 resembles that of the related PIKK, ATM, both in terms of substrate specificity and its sensitivity to inhibition by the fungal metabolite wortmannin...
  63. ncbi Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    Zhao Hui Wu
    Department of Pharmacology, University of Wisconsin Madison, 301 SMI, 1300 University Avenue, Madison, WI 53706, USA
    Science 311:1141-6. 2006
    ..IkappaB kinase (IKK) (which phosphorylates the NF-kappaB inhibitor IkappaB), associates with activated ataxia telangiectasia mutated (ATM) after the induction of DNA double-strand breaks...
  64. doi Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells
    Melli Mahmoudi
    Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom
    Circ Res 103:717-25. 2008
    ..of double-stranded DNA breaks and basal activation of DNA repair pathways involving ataxia telangiectasia-mutated (ATM) and the histone H2AX in vivo and in vitro...
  65. pmc ATM binds to beta-adaptin in cytoplasmic vesicles
    D S Lim
    Oncology Center, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:10146-51. 1998
    ..Using the yeast two-hybrid system, we demonstrate that ataxia telangiectasia mutated (ATM) binds to beta-adaptin, one of the components of the AP-2 adaptor complex, which is involved in ..
  66. ncbi Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer
    L Izatt
    Division of Medical and Molecular Genetics, Guy s, King s and St Thomas Schools of Medicine and Dentistry and Biomedical Sciences GKT, London, England
    Genes Chromosomes Cancer 26:286-94. 1999
    ..We analyzed 100 samples from young breast cancer patients for mutations in ataxia-telangiectasia mutated (ATM), the gene responsible for the autosomal recessive condition, A-T, to determine whether A-T heterozygosity ..
  67. ncbi CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM
    Lingqiang Zhang
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Beijing Proteome Reseacrh Center, Beijing 100850, P R China
    Cell Signal 18:1386-95. 2006
    ..CKIP-1 could interact with ATM, which is an upstream kinase of p53, thereby enhance the stability of p53...
  68. ncbi Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation
    Mukesh K Nyati
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 66:11554-9. 2006
    b>Ataxia telangiectasia mutated (ATM) kinase plays a crucial role in the cellular response to DNA damage and in radiation resistance...
  69. pmc A role for DEAD box 1 at DNA double-strand breaks
    Lei Li
    Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Mol Cell Biol 28:6413-25. 2008
    ..ionizing radiation, resulting in the formation of numerous foci that colocalize with gamma-H2AX and phosphorylated ATM foci at sites of DNA double-strand breaks (DSBs)...
  70. ncbi Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease
    Marielle Ousset
    University of Toulouse, UPS, IPBS, Toulouse, France
    Cell Cycle 9:2814-22. 2010
    ..The gene mutated in this disease, ATM (Ataxia Telangiectasia Mutated), encodes a protein kinase involved in DNA double strand breaks signalling and repair...
  71. pmc The Mre11 complex is required for ATM activation and the G2/M checkpoint
    Christian T Carson
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 22:6610-20. 2003
    ..The conserved and related PI3-like protein kinases, ataxia-telangiectasia mutated (ATM) and ATM-Rad3-related (ATR), orchestrate signal transduction pathways in response to genomic insults, such as DNA ..
  72. pmc Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses
    R Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 21:1164-72. 2001
    ..3-kinase (PI-3K)-related PKs, including the catalytic subunit of DNA-dependent protein kinase (DNA-PK(CS)) and ATM, sensitizes normal murine lymphocytes to retrovirus-mediated cell killing...
  73. ncbi Dominant negative ATM mutations in breast cancer families
    Georgia Chenevix-Trench
    Queensland Institute of Medical Research, Brisbane, Australia
    J Natl Cancer Inst 94:205-15. 2002
    The ATM gene encoding a putative protein kinase is mutated in ataxia-telangiectasia (A-T), an autosomal recessive disorder with a predisposition for cancer...
  74. ncbi The relationship between twenty missense ATM variants and breast cancer risk: the Multiethnic Cohort
    Philip Bretsky
    University of Southern California Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 12:733-8. 2003
    ..The gene mutated in ataxia-telangiectasia (A-T), ATM, is a proximal component in performing such tasks...
  75. ncbi The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells
    Kathryn M Brumbaugh
    Program in Signal Transduction Research, The Burnham Institute, La Jolla, CA 92037, USA
    Mol Cell 14:585-98. 2004
    ..as a genotoxic stress-activated protein kinase that displays some functional overlap with the related kinase, ATM, in human cells...
  76. ncbi Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
    Tiziana Bruno
    Experimental Chemotherapy Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy
    Cancer Cell 10:473-86. 2006
    ..The checkpoint kinases ATM/ATR and Chk2 interact with Che-1 and promote its phosphorylation and accumulation in response to DNA damage...
  77. pmc A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage
    Xi Tang
    Department of Biochemistry and Molecular Biology, Southern Research Institute, 2000 9th Ave South, Birmingham, AL 35205, USA
    Mol Cell Biol 28:2559-66. 2008
    ..of PP1 from its regulatory subunit inhibitor-2 (I-2) and that the process requires ataxia-telangiectasia mutated (ATM), a protein kinase central to DNA damage responses...
  78. doi Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer
    M Schrauder
    University Breast Center for Franconia, Erlangen University Hospital, Universitaetsstrasse 21 23, 91054, Erlangen, Bavaria, Germany
    J Cancer Res Clin Oncol 134:873-82. 2008
    Various ATM (ataxia telangiectasia-mutated) mutations and polymorphisms have been reported to be associated with an increased breast cancer risk...
  79. ncbi The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
    K Savitsky
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Hum Mol Genet 4:2025-32. 1995
    ..A-T heterozygotes are moderately cancer prone. The A-T gene, designated ATM, was recently identified in our laboratory by positional cloning, and a partial cDNA clone was found to encode a ..
  80. pmc Mutations associated with variant phenotypes in ataxia-telangiectasia
    C M McConville
    CRC Institute for Cancer Studies, University of Birmingham, United Kingdom
    Am J Hum Genet 59:320-30. 1996
    We have identified 14 families with ataxia-telangiectasia (A-T) in which mutation of the ATM gene is associated with a less severe clinical and cellular phenotype (approximately 10%-15% of A-T families identified in the United Kingdom)...
  81. ncbi Predominance of null mutations in ataxia-telangiectasia
    S Gilad
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Hum Mol Genet 5:433-9. 1996
    ..The responsible gene, ATM, was recently identified by positional cloning and found to encode a putative 350 kDa protein with a Pl 3-kinase-..
  82. ncbi DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    E P Rogakou
    Laboratory of Molecular Pharmacology, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:5858-68. 1998
    ..Thus, gamma-H2AX formation is a rapid and sensitive cellular response to the presence of DNA double-stranded breaks, a response that may provide insight into higher order chromatin structures...
  83. ncbi ATM associates with and phosphorylates p53: mapping the region of interaction
    K K Khanna
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Nat Genet 20:398-400. 1998
    ..The gene mutated in this syndrome, ATM (for AT mutated), encodes a protein containing a phosphatidyl-inositol 3-kinase (PI-3 kinase)-like domain...
  84. ncbi Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
    G D Kim
    Department of Radiation Medicine, Division of Radiation Research, Vincent T Lombardi Cancer Center, Georgetown University Medical Center, Washington, D C 20007, USA
    J Biol Chem 274:31127-30. 1999
    The ATM gene is mutated in individuals with ataxia telangiectasia, a human genetic disease characterized by extreme sensitivity to radiation...
  85. ncbi Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
    D Cortez
    Verna and Mars McLean Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 286:1162-6. 1999
    ..Results from this study indicate that the checkpoint protein kinase ATM (mutated in ataxia telangiectasia) was required for phosphorylation of Brca1 in response to ionizing radiation...
  86. ncbi Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
    S Li
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 78245, USA
    Nature 406:210-5. 2000
    ..This phosphorylation event requires the protein kinase (ATM) that is mutated in the disease ataxia telangiectasia...
  87. ncbi Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
    D Q Yang
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    Nat Cell Biol 2:893-8. 2000
    ..Here we report that ATM, the protein product of the ATM gene that is mutated in the disease ataxia telangiectasia, phosphorylates 4E-BP1 at ..
  88. ncbi ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    S Burma
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 276:42462-7. 2001
    ..Although the phosphatidylinositol 3-kinases, DNA-PK (DNA-dependent protein kinase), ATM (ataxia telangiectasia mutated), and ATR (ATM and Rad3-related), have all been implicated in H2AX phosphorylation, the specific ..
  89. ncbi A new type of mutation causes a splicing defect in ATM
    Franco Pagani
    Molecular Pathology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Nat Genet 30:426-9. 2002
    ..The gene ATM is mutated in individuals with ataxia-telangiectasia; we have identified the aberrant inclusion of a cryptic exon ..
  90. ncbi Elevated frequency of ATM gene missense mutations in breast cancer relative to ethnically matched controls
    Steve S Sommer
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Genet Cytogenet 134:25-32. 2002
    ..However, expected increased levels of mutations in the ATM gene among unselected breast cancer patients have not been found to date...
  91. ncbi Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    KWOK KIN WONG
    Department of Adult Oncology, Dana Farber Cancer Institute Boston, Massachusetts 02115, USA
    Nature 421:643-8. 2003
    Ataxia-telangiectasia (A-T) results from the loss of ataxia-telangiectasia mutated (Atm) function and is characterized by accelerated telomere loss, genomic instability, progressive neurological degeneration, premature ageing and ..
  92. pmc A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
    Nicolas Foray
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    EMBO J 22:2860-71. 2003
    ..We show here that BRCA1 is required for ATM- and ATR-dependent phosphorylation of p53, c-Jun, Nbs1 and Chk2 following exposure to ionizing or ultraviolet ..
  93. pmc Requirement of the MRN complex for ATM activation by DNA damage
    Tamar Uziel
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    EMBO J 22:5612-21. 2003
    The ATM protein kinase is a primary activator of the cellular response to DNA double-strand breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in various branches of the DNA damage response network...
  94. ncbi Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells
    Sarah E Golding
    Department of Radiation Oncology, Pharmacology and Toxicology, Medical College of Virginia, Virginia 23298, USA
    J Biol Chem 279:15402-10. 2004
    ..To investigate double strand break (DSB) repair and signaling in human glioma cells, we stably transfected human U87 (ATM(+), p53(+)) glioma cells with a plasmid having a single I-SceI site within an inactive green fluorescent protein (..
  95. ncbi Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation
    Zuzana Horejsi
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK 2100 Denmark
    Oncogene 23:3122-7. 2004
    The ATM kinase is a tumour suppressor and a key activator of genome integrity checkpoints in mammalian cells exposed to ionizing radiation (IR) and other insults that elicit DNA double-strand breaks (DSBs)...
  96. ncbi Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm
    Karen Cerosaletti
    Molecular Genetics Program, Benaroya Research Institute at Virginia Mason, USA
    J Biol Chem 279:38813-9. 2004
    The Atm protein kinase and Mre11-Rad50-nibrin (MRN) complex play an integral role in the cellular response to DNA double-strand breaks...
  97. ncbi Cancer risk according to type and location of ATM mutation in ataxia-telangiectasia families
    E Cavaciuti
    Inserm Emi 00 06, Evry, France
    Genes Chromosomes Cancer 42:1-9. 2005
    ..However, in BC case-control studies, no significant differences were found in the frequency of ATM mutations between patients and controls...
  98. pmc Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
    Aaron A Goodarzi
    Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
    EMBO J 23:4451-61. 2004
    Ionizing radiation induces autophosphorylation of the ataxia-telangiectasia mutated (ATM) protein kinase on serine 1981; however, the precise mechanisms that regulate ATM activation are not fully understood...
  99. ncbi Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage
    Christopher E Helt
    Department of Environmental Medicine, School of Medicine and Dentistry, The University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:1186-92. 2005
    The ataxia telangiectasia mutated (ATM) and ATR (ATM and Rad3-related) protein kinases exert cell cycle delay, in part, by phosphorylating Checkpoint kinase (Chk) 1, Chk2, and p53...
  100. ncbi Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    Jacob Falck
    The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, Cambridge University, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 434:605-11. 2005
    Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are members of the phosphoinositide-3-kinase-related protein kinase (PIKK) family, and are ..
  101. ncbi Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association
    David B Young
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    J Biol Chem 280:27587-94. 2005
    Ataxia-telangiectasia mutated (ATM) is essential for rapid induction of cellular responses to DNA double strand breaks (DSBs)...

Research Grants79

  1. Tahir Hussain; Fiscal Year: 2016
    ..Of the two Ang II receptors, AT1 is known to mediate most of the Ang II actions such as antinatriuresis and increased blood pressure (BP)...
  2. Brain specific non-AT1, non-AT2 angiotensin binding site
    ROBERT CHARLES SPETH; Fiscal Year: 2010
    ..We recently discovered a non-AT1, non-AT2 binding site in the brain that may add an additional layer of complexity to the brain angiotensin system...
  3. Mohammad Asghar; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Renal dopamine D1 and angiotensin II AT1 receptors by regulating proximal tubular sodium transporters maintain sodium homeostasis and blood pressure...
  4. Role of angiotensin II receptor signaling pathways in body fluid homeostasis
    Derek Daniels; Fiscal Year: 2013
    ..These behavioral effects are mediated largely through AngII type 1 (AT1) receptors, which stimulate several intracellular signaling pathways including one that leads to increased inositol ..
  5. Horng H Chen; Fiscal Year: 2016
    ..We demonstrated that angiotensin II receptor (AT1) blockade prevented the detrimental renal effects of diuretics...
  6. Mark R Plummer; Fiscal Year: 2014
    ..The gene, named ataxia- telangiectasia mutated (ATM) is a recognized component of the response mechanism to DNA double strand breaks...
  7. JASON MARK BECKTA; Fiscal Year: 2014
    ..Recently, data has arisen demonstrating that the ataxia telangiectasia-mutated (ATM) kinase mediates this checkpoint, conflicting with older reports which posit that ATM has no part in executing cell ..
  8. Peter J McKinnon; Fiscal Year: 2016
    ..telangiectasia (A-T), which results from loss of function of the DNA damage-signaling serine/threonine kinase ATM (ataxia telangiectasia, mutated), exemplifies the importance of genome stability in the nervous system...
  9. Barry P Sleckman; Fiscal Year: 2016
    ..PUBLIC HEALTH RELEVANCE: The ataxia telangiectasia mutated (ATM) protein is a critical initiator of DNA damage responses...
  10. Tej K Pandita; Fiscal Year: 2014
    ..In this grant application we propose to understanding how inactivation of ataxia-telangiectasia mutated (ATM) and telomerase could enhance heat mediated and IR-induced tumor cell killing...
  11. JOHN HJ PETRINI; Fiscal Year: 2016
    ..Genetic interactions with these mice and mice mutants in p53, ATM and PTEN will be examined to test the hypothesis that chromosome instability in Rad50 mutants will increase the ..
  12. Nuclear Function of the c-Abl Protooncoprotien
    Jean Wang; Fiscal Year: 2007
    ..The retinoblastoma tumor suppressor (RB) inhibits c-Abl in G0G1 nuclei. The Ataxia Telangiectasia Mutated gene product (ATM) can further activate c-Abl in S phase nuclei after DNA is damaged...
  13. The role of LKB1 in the maintenance of genomic stability.
    Zhi Xiang Xu; Fiscal Year: 2013
    ..We found that LKB1 interacts with ATM, BRCA1, and other DNA damage response (DDR) proteins in vivo...
  14. Christie P Thomas; Fiscal Year: 2014
    ..to study alternate processing of the primary transcripts of FLT1, focusing on hypoxia and angiotensin II type 1 (AT1) receptor activation, two pathways that increase sFlt1 expression...
  15. Jean F Regal; Fiscal Year: 2015
    ..preeclampsia have focused on mediators of hypertension including autoantibodies to angiotensin II type I receptor (AT1-AA) and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 despite the observation that many women ..
  16. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..The angiotensin (Ang) converting enzyme (ACE), Ang II and Ang AT1 receptor of the renin-angiotensin system (RAS) participate in the pathophysiology of various cardiovascular ..
  17. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ..disorders, induces cholangiocyte proliferation via mechanical activation of the angiotensin type 1 receptor (AT1)...
  18. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Given the fact that RSNA can increase AngII type 1 (AT1) receptor expression, we speculate that increased baseline RSNA in MS rats results in increased renal AngII system ..
  19. Analia Loria; Fiscal Year: 2015
    ..Given the fact that RSNA can increase AngII type 1 (AT1) receptor expression, we speculate that increased baseline RSNA in MS rats results in increased renal AngII system ..
  20. Babbette LaMarca; Fiscal Year: 2016
    ..cytokines, neutrophils and lymphocytes producing an agonistic autoantibody to the angiotensin II type I receptor (AT1-AA)...
  21. The role of T lymphocytes in mediating hypertension during pregnancy
    Kedra L Wallace; Fiscal Year: 2013
    ..cytokines, neutrophils and lymphocytes producing an agonistic autoantibody to the angiotensin II type I receptor (AT1-AA)...
  22. Exercise training improves erectile dysfunction in diabetes: role of central mech
    Kaushik P Patel; Fiscal Year: 2012
    ..NMDA- induced erection in T1D rats, 5) plasma levels of angiotensin II (Ang II) are increased and Ang II type 1 (AT1) receptors in the PVN are up-regulated in T1D rats, 6) Ang II modulates autonomic outflow via a reactive oxygen ..
  23. Roles of Phospholipase D in AT1 Receptor Endocytosis
    Guangwei Du; Fiscal Year: 2010
    ..AT1R activation in different subcellular locations results in distinct signaling outputs. We will determine whether PLD2 downregulation changes the kinetic and spatial patterns of Ang II signaling, and as a result, affects cell growth. ..
  24. Emily M Garland; Fiscal Year: 2014
    ..To test the hypothesis that in patients with POTS that AT1 Receptor mediated aldosterone release is blunted. 2...
  25. Novel Aspects of the Cardiac Renin-Angiotensin System
    KENNETH MELVIN BAKER; Fiscal Year: 2012
    ..The effects of angiotensin II (Ang II) are primarily mediated by binding to AT1 receptor in an endocrine and/or autocrine/paracrine manner...
  26. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia Zhuo; Fiscal Year: 2009
    ..that a) circulating and paracrine Ang II is taken up by proximal tubule cells in culture or by the kidney via an AT1 (AT1a) receptor-mediated mechanism;b) microinjection of Ang II directly into the cells can induce intracellular ..
  27. Renal AT2 Receptors in Hypertension
    ROBERT MUNSON CAREY; Fiscal Year: 2013
    ..Angiotensin II (Ang II), the main effector peptide of the RAS, acts at two major receptors, AT1 and AT2...
  28. Steven D Crowley; Fiscal Year: 2016
    ..We therefore suggest that Ang II acting through type I angiotensin (AT1) receptors promotes the development of a Th1 immune response in the kidney, with enhanced production of IFN-g and ..
  29. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia L Zhuo; Fiscal Year: 2013
    ..have evidence that a) circulating and paracrine Ang II is taken up by PT cells in culture or by the kidney via an AT1 (AT1a) receptor-mediated mechanism;b) microinjection of Ang II directly into the cells can induce intracellular ..
  30. Salt appetite & vascular remodeling in fetal origin
    Zhice Xu; Fiscal Year: 2010
    ..the effects of maternal high salt ingestion on the development of fetal swallowing behavior, ANG receptor subtypes-AT1?R and AT2-R, and vascular homeostasis, as well as long-term programming influence on cardiovascular regulation in ..
  31. Central actions of angiotensin II in the control of fluid balance
    Daniel K Yee; Fiscal Year: 2013
    ..The Type 1 (AT1) AngII receptor subtype is primarily responsible for the physiological and behavioral responses to this peptide...
  32. Integrated Modeling of Adaptive Neuronal Regulation
    Rajanikanth Vadigepalli; Fiscal Year: 2012
    ..Aim 1, with focus on the AT1 receptor- to-signaling-to-electrophysiology, will develop a mathematical model of the rapid and transient ..
  33. Aldosterone and Glucose Metabolism
    JAMES MATTHEW LUTHER; Fiscal Year: 2012
    ..SPECIFIC AIM 3 Test the hypothesis that MR antagonism and angiotensin II type-1 receptor (AT1) antagonism will cause synergistic beneficial effects on fasting blood glucose and insulin secretion...
  34. Role of Gbeta 2 in the Nucleus of Angiotensin Receptor Activated Cells
    Anushree Bhatnagar; Fiscal Year: 2010
    ..Both types of Ang II actions are mediated by AT1 receptors...
  35. Steven D Crowley; Fiscal Year: 2015
    ..regulators of M1/M2 macrophage differentiation include T lymphocyte subpopulations and type 1 angiotensin (AT1) receptors on macrophages...
  36. Strategies for ACE2 Amplification to Treat Diabetic Kidney Disease
    Daniel Batlle; Fiscal Year: 2012
    ..approach of either inhibiting angiotensin II formation using ACE inhibitors or blocking its action using specific AT1 receptor antagonists...
  37. Frank M Faraci; Fiscal Year: 2016
    ..Detrimental effects of the RAS are commonly due to Ang II acting on AT1 receptors resulting in activation of many downstream targets and oxidative stress...
  38. JoAnn Sekiguchi; Fiscal Year: 2014
    ..The gene mutated in A-T, ataxia-telangiectasia mutated (ATM), has been identified and encodes a large serine-threonine protein kinase...
  39. NAHID JAMAL RIANON; Fiscal Year: 2014
    ..ACEI prevents generation of angiotensin II, which impacts bone via receptors AT1 and AT2...
  40. Colin Sumners; Fiscal Year: 2014
    ..blood pressure, and the physiological mechanisms involved in this effect include angiotensin type 1 receptor (AT1-R)-mediated activation of sympathetic vasomotor neurons at the paraventricular nucleus of the hypothalamus (PVN)...
  41. Effects of an angiotensin ll antagonist in a rat model of insomnia
    Georgina Cano; Fiscal Year: 2013
    ..Recent work suggests that brain AngII is involved in the regulation of stress responses. Central AngII and AngII AT1 receptor expression increase during stress and, in turn, activate both the sympathoadrenal and neuroendocrine ..
  42. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    Funds are requested for partial support towards the 14th International Workshop on Ataxia-Telangiectasia and ATM, which will be held at the Crowne Plaza Hotel in Redondo Beach, CA. on April 11-14, 2010...
  43. Central AT1 receptors and the integrated stress response.
    ERIC GERALD KRAUSE; Fiscal Year: 2010
    ..These studies are designed to test the overall hypothesis that inhibition of AT1R in the subfornical organ will limit stress responding and alleviate the deleterious consequences of chronic stress exposure. ..
  44. Angiotensin Receptor AT1 in Cardiovascular Cell Control.
    Tadashi Inagami; Fiscal Year: 2010
    ..It is based on new findings of cross-talk between epidermal receptor and the Ang II type 1 (AT1) receptor in extracellular signal-response kinase (ERK), as well as involvement of several non-receptor tyrosine ..
  45. ADAM activation by Angiotensin II
    Satoru Eguchi; Fiscal Year: 2012
    Angiotensin II (AngII) and its G protein-coupled AT1 receptor play critical roles in mediating cardiovascular diseases such as hypertension, atherosclerosis, and restenosis after vascular injury...
  46. Geoffrey I Shapiro; Fiscal Year: 2014
    ..This work will focus on the interaction of cdks with DNA damage pathways. Cdks are major targets of ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) checkpoint cascades in response to DNA damage, and ..
  47. Mechanisms of action of angiotensin-II on C1 neurons.
    Seth D DePuy; Fiscal Year: 2010
    ..Under pathological conditions, upregulation of the RAS, including AT1 receptors and angiotensin converting enzyme (ACE), produces a tonic activation of presympathetic neurons that can ..
  48. Molecular Mechanism of PGE2 Receptor Pressor Effects
    Richard M Breyer; Fiscal Year: 2011
    ..In vitro studies will focus on the downstream receptor signal transduction of AT1 angiotensin receptor and PGE2 EP receptors to investigate evidence of receptor synergy...
  49. Oleg Alekseev; Fiscal Year: 2015
    ..by HSV-1 is the DNA damage response (DDR), initiated by the phosphorylation of a sensor kinase ataxia telangiectasia mutated (ATM)...
  50. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
    ..of angiotensin-based therapies - from the serendipitous identification of ACE inhibitors in snake venom, through AT1 receptor blockers, renin inhibitors, AT2 receptor agonists, recombinant ACE2 therapies as well as the latest ..
  51. AngII-Salt Hypertension Increases Respiratory-Vasomotor Neuron Coupling in RVLM
    Glenn M Toney; Fiscal Year: 2013
    ..major innovation is the concept that exaggerated respiratory-SSNA coupling is mediated by [1] activation of AngII AT1 receptors and [2] prostaglandin E2 (PGE2) EP3 receptors in the RVLM...
  52. Michael B Kastan; Fiscal Year: 2016
    ..The ATM protein kinase is a central signaling molecule in modulating cellular responses to DNA breakage...
  53. BROOKE ELIZABETH CHRISTIAN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Ataxia-Telangiectasia (A-T) is caused by mutations in the ATM gene, which encodes the Ataxia-Telangiectasia Mutated kinase (ATM)...
  54. Mechanisms of ATM activation
    Tanya T Paull; Fiscal Year: 2013
    The ATM protein kinase is a master regulator of the cellular response to chromosomal DNA double-strand breaks...
  55. RANDAL SCOT TIBBETTS; Fiscal Year: 2016
    ..We discovered that CREB is regulated by the ATM (ataxia-telangiectasia-mutated) protein kinase, which is a tumor suppressor protein that functions as master ..
  56. Targeted Degradation of DNA Damage Response Proteins by Autophagy
    Thomas J Begley; Fiscal Year: 2013
    ..mTOR inhibition and the induction of autophagy have been linked to p53 and Ataxia-telangiectasia mutated (ATM) signaling after DNA damage...
  57. Genetic Analysis of Ataxia-telangiectasia
    DAVID WASSARMAN; Fiscal Year: 2012
    ..The gene responsible for A-T, ATM (A-T mutated) encodes a protein kinase that plays a central role in the response to DNA damage in humans and other ..
  58. 15th International Workshop on Ataxia-Telangiectasia and ATM to be held in India
    Tej K Pandita; Fiscal Year: 2012
    ..Funds are requested for partial support towards the 15th International Workshop on Ataxia- Telangiectasia and ATM, (ATW2012) which wil be held at the India Habitat Center, Delhi, India (http://www.indiahabitat...
  59. KATSONURI SUGIMOTO; Fiscal Year: 2015
    ..ATM kinase is encoded by TEL1 in budding yeast. ATM/Tel1 localizes to DSBs by interacting Mre11-Rad50-Nbs1/Xrs2 (MRN/MRX) complex...
  60. In vivo Analysis of ATM-Regulated Pathways
    RANDAL SCOT TIBBETTS; Fiscal Year: 2011
    ..major objectives of this application are to: (i) functionally characterize a signal transduction pathway linking ATM (ataxia-telangiectasia-mutated) to the cyclic AMP response element-binding protein (CREB) transcription factor;and (..
  61. BRAIN AND CARDIAC ANGIOTENSIN II IN HYPERTENSION
    KATHLEEN BERECEK; Fiscal Year: 2003
    ..effects of early, short- term ACE inhibitor therapy or single intracardiac injection of the angiotensin II AT1 receptor subtype antisense cDNA (AT1 R-AS) to SHR...
  62. The Mas Receptor is Required for Angiotensin-(1-7) Effects in Cardiac Remodeling
    Barry H Greenberg; Fiscal Year: 2012
    ..We have shown that Mas heterodimerization with the AT1 receptor affects AT1 expression and function...
  63. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas M Coffman; Fiscal Year: 2010
    The actions of the renin-angiotensin system (RAS) to control blood pressure are primarily mediated by type I (ATd angiotensin receptors...
  64. Lauren Endres; Fiscal Year: 2014
    ..Indeed, defects in components of the DDR, such as ATM, BRCA1 and p53 are known to cause a predisposition to cancer development as well as hypersensitivity to ultraviolet ..
  65. Regulation of the ATM/ATR-p53 DNA Damage Signaling Pathway by the Wip1 Phosphatas
    Xiongbin Lu; Fiscal Year: 2013
    ..The goal of this research project is to (1) clarify the functions of Wip1 in the ATM (Ataxia Telangiectasia Mutated) initiated DNA damage response pathway;(2) determine if inhibiting Wip1 would rescue ATM deficiency in ..
  66. Identification of Novel Protein Phosphatases in the ATM Signaling Pathway
    Xiongbin Lu; Fiscal Year: 2010
    ..The goal of this research project is to (1) clarify the functions of protein phosphatases in the ATM (Ataxia Telangiectasia Mutated) initiated DNA damage response pathway;(2) determine how protein phosphatases regulate DNA damage-..
  67. Chromatin remodeling specific interactions of ATM
    Sundaresan Venkatachalam; Fiscal Year: 2009
    ..by applicant): DNA damage induces a variety of responses that are initiated by the ataxia- telangiectasia mutated (ATM) and ataxia- telangiectasia and Rad 3-related (ATR) kinases...
  68. Glial Dysfunction in Ataxia Telangiectasia
    Margot Mayer Proschel; Fiscal Year: 2009
    ..die during the second or early third decade of life and while the genetic lesions responsible for AT (called ATM, for AT-mutated) were first identified in 1988, no known therapy has been identified...
  69. 12th International Workshop on Ataxia-Telangiectasia and ATM
    Richard Gatti; Fiscal Year: 2006
    ..In addition, it has been estimated that up to 1% of the general population carries mutations in one allele of the ATM (ataxia-telangiectasia mutated) gene and ATM heterozygotes have an increased risk of developing breast cancer...
  70. RISK OF CANCER IN A-T FAMILIES
    Robert Haile; Fiscal Year: 2003
    ..subjects who are heterozygotes for mutation in the gene presently identified as a cause of ataxia-telangiectasia (ATM) have a higher that expected risk of cancer, with a primary focus on breast cancer. Specific aims are the following...
  71. Role of ATM in Cardiac Myocyte Loss and Myocardial Remodeling
    Krishna Singh; Fiscal Year: 2009
    Ataxia telangiectasia (A-T) results from mutation of the ATM gene. Individuals with an ATM mutation in one allele are spared from most of the symptoms of the disease, but are more susceptible to cancer and ischemic heart disease...
  72. Regulation of non-histone protein functions by histone deacetylases
    Edward Seto; Fiscal Year: 2010
    ..The ataxiatelangiectasia group D complementing (ATDC) gene was originally isolated on the basis of its ability to complement the ionizing radiation sensitivity defect ..
  73. Defining a Role for ATM in the Nervous System
    Carrolee Barlow; Fiscal Year: 2004
    ..We generated mice deficient in ATM (Atm-deficient mice) that recapitulate most aspects of the human disease showing neurological dysfunction, ..
  74. ATM and ATR in Chromium-Induced S-Phase Arrest
    Bo Xu; Fiscal Year: 2005
    ..experiments in this application is our preliminary observations that Ataxia-Telangiectasia-Mutated protein kinase (ATM) and its related kinase ATR are required for Cr-induced intra S-phase arrest...
  75. Deregulation of the Ubiquitin/26S Proteasome Pathway in AT cells: Role of ISG15
    SHYAMAL DESAI; Fiscal Year: 2009
    ..as an autosomal recessive mutation in the Ataxia Telangiectasia (ATM) gene...
  76. Role of ATM in Radiosensitivity of Gliomas
    Chandan Guha; Fiscal Year: 2004
    ..the results of radiotherapy we propose to increase the intrinsic radiosensitivity of GBM by selectively targeting ATM (Ataxia-Telangiectasia mutated), which is a key mediator of the DNA damage surveillance pathway in an irradiated ..
  77. Cooperative roles for Atm and Hus1 in genome maintenance
    Robert Weiss; Fiscal Year: 2009
    ..Ataxia-Telangiectasia is a genomic instability syndrome in which mutations in the DNA damage checkpoint protein Atm cause neurodegeneration, cancer predisposition, infertility, and immune dysfunction...