Genomes and Genes
Gene Symbol: Bcl 2
Description: BCL2, apoptosis regulator
Alias: Bcl-2, PPP1R50, apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, protein phosphatase 1, regulatory subunit 50
Publications384 found, 100 shown here
- Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membraneThomas Kaufmann
Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, D 79106 Freiburg, Germany
J Cell Biol 160:53-64. 2003..These data define a new targeting sequence for the MOM and propose that Bcl-2 acts on several intracellular membranes whereas Bcl-x(L) specifically functions on the MOM...
- Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1Jean Marie Bruey
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Cell 129:45-56. 2007..The findings reveal an interaction of host defense and apoptosis machinery...
- Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1Natasha C Chang
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
EMBO J 29:606-18. 2010..NAF-1 is required in this pathway for BCL-2 at the ER to functionally antagonize Beclin 1-dependent autophagy. Thus, NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the ER...
- The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent mannerAslamuzzaman Kazi
Drug Discovery Department, Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
J Biol Chem 286:9382-92. 2011..Finally, BH3-M6 sensitizes cells to apoptosis induced by the proteasome inhibitor CEP-1612...
- Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signalingEmily F Eckenrode
Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
J Biol Chem 285:13678-84. 2010..Our data suggest a molecular mechanism that is shared by several anti-apoptotic Bcl-2 proteins that provides apoptosis resistance by direct interactions at the ER with the InsP(3)R that impinges on cellular Ca(2+) homeostasis...
- The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737Mariana Boiani
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 288:6980-90. 2013..These studies identify BAG3-mediated Mcl-1 stabilization as a potential target for cancer drug discovery...
- Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriersK Tsukasaki
Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
Cancer Res 61:3770-4. 2001....
- HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAsJ Robert Chang
Department of Neurology, Molecular Studies of Neurodegenerative Diseases Laboratory, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Biol Chem 286:41125-34. 2011..Therefore, we conclude that deregulation of neuronal functions by HIV-1 Tat protein is miRNA-dependent...
- Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cellsAlejo A Morales
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA
Blood 118:1329-39. 2011..Overall, these results suggest that complex interactions, and not simply expression patterns of Bcl-2 proteins, need to be investigated to understand Bcl-2 dependence and how to better use agents, such as ABT-737...
- HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cellsMaria Chiara Deregibus
Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
J Biol Chem 277:25195-202. 2002....
- The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2T Yang
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755 3835
J Cell Biol 128:1173-84. 1995..A burst of expression of mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells differentiating along the monocyte/macrophage pathway...
- Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1Shuang Chen
Department of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
Mol Cell Biol 29:6149-69. 2009....
- Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell deathZ N Oltvai
Howard Hughes Medical Institute Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
Cell 74:609-19. 1993..Overexpressed Bax also counters the death repressor activity of Bcl-2. These data suggest a model in which the ratio of Bcl-2 to Bax determines survival or death following an apoptotic stimulus...
- Prognostic relevance of a novel semiquantitative classification of Bcl2 immunohistochemical expression in human infiltrating ductal carcinomas of the breastD Trere
Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Italy
Ann Oncol 18:1004-14. 2007..In the present study, we evaluated the clinical relevance of a novel, semiquantitative classification of the Bcl2 immunostaining based on both the distribution and the intensity of the staining reaction...
- Prognostic significance of COX-2 expression and correlation with Bcl-2 and VEGF expression, microvessel density, and clinical variables in classical Hodgkin lymphomaYoung Wha Koh
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Am J Surg Pathol 37:1242-51. 2013..013). COX-2 and VEGF correlated with angiogenesis and tumor progression in cHL. The findings support targeting COX-2 as a potential new therapeutic approach in cHL. ..
- Correlation between chemosensitivity to anticancer drugs and Bcl-2 expression in gastric cancerMing Geng
Department of Pathology, General Hospital of Jinan Military Command Jinan, China
Int J Clin Exp Pathol 6:2554-9. 2013..To investigate chemoresistance of human gastric cancer to chemotherapeutic drugs in vitro and explore the relationship with Bcl-2 protein expression...
- Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferationZhaohui Jin
University of Florida Shands Cancer Center, Department of Medicine, University of Florida, Gainesville, Florida 32610 0232, USA
J Biol Chem 279:40209-19. 2004....
- Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell deathKyung Jin Park
Dept of Molecular Science and Technology, Ajou University, Yeongtong Gu, Suwon, Republic of Korea
Biochem Biophys Res Commun 382:726-9. 2009..Our results suggest that DR5-stimulated JNK activation and its consequent fluxes into the pro-autophagic signaling pathways contribute to the autophagic cell death in cancer cells...
- Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XLEinat Zalckvar
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Autophagy 5:720-2. 2009..Our results reveal a new phosphorylation-based mechanism that reduces the interaction of Beclin 1 with its inhibitors to activate the autophagic machinery...
- Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1Luke R E Harrison
Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom
J Clin Invest 121:1075-87. 2011....
- miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumorsMarina Gonçalves Diniz
Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Cell Oncol (Dordr) 35:285-91. 2012..The purpose of this study was to investigate whether the transcription of miR-15a and miR-16-1 is altered in KCOTs and whether it is associated with BCL2 gene expression in such lesions...
- Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulumScott A Oakes
Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:105-10. 2005..These findings support a model in which BCL-2 family members regulate IP3R-1 phosphorylation to control the rate of ER Ca(2+) leak from intracellular stores...
- The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDSL Conti
Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
J Exp Med 187:403-13. 1998..This might explain why apoptosis mostly occurs in bystander uninfected cells in AIDS patients...
- Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2John J Zaunders
Centre for Immunology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
J Infect Dis 187:1735-47. 2003..Understanding cytokine effects on CCR5(+) T cells will be important in understanding chronic HIV-1 replication and pathogenesis...
- Apoptotic regulation by MCL-1 through heterodimerizationQian Liu
Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 285:19615-24. 2010..We also present the solution structure of complex cMCL-1xhBID-BH3, which completes the family portrait of MCL-1 complexes and may facilitate drug discovery against human tumors...
- Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store contentC Jane Hanson
Laboratory of Molecular Signalling, Babraham Institute, Babraham, Cambridge CB2 4AT, UK
Cell Calcium 44:324-38. 2008..Our data suggest that the presence of Bcl-2 in the proteome of cells has multiple effects on agonist-mediated Ca2+ signals, and can abrogate responses to submaximal levels of stimulation through direct control of InsP3Rs...
- BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sitesR Ray
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
J Biol Chem 275:1439-48. 2000..We propose that BNIP3 represents a subfamily of Bcl-2-related proteins that functions without a typical BH3 domain to regulate apoptosis from both mitochondrial and nonmitochondrial sites by selective Bcl-2/Bcl-X(L) interactions...
- Coxiella burnetii modulates Beclin 1 and Bcl-2, preventing host cell apoptosis to generate a persistent bacterial infectionC L Vazquez
Laboratorio de Biología Celular y Molecular Instituto de Histología y Embriología IHEM, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza, Argentina
Cell Death Differ 17:421-38. 2010..Overall, these findings indicate that C. burnetii infection modulates autophagy and apoptotic pathways through Beclin 1/Bcl-2 interplay to establish a successful infection in the host cell...
- Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2P R Strack
Molecular Biology Department, DuPont Merck Pharmaceutical Company, Wilmington, DE 19880 0336, USA
Proc Natl Acad Sci U S A 93:9571-6. 1996..Purified bcl-2 is cleaved by HIV protease between phenylalanine 112 and alanine 113. The results suggest a new option for HIV gene therapy; bcl-2 muteins that have noncleavable alterations surrounding the HIV protease cleavage site...
- A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosisP P Ruvolo
Sealy Center for Oncology and Hematology and the Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555, USA
J Biol Chem 273:25436-42. 1998..Collectively, these findings identify a functional role for PKCalpha in Bcl2 phosphorylation and in resistance to chemotherapy and suggest a novel target for antileukemic strategies...
- Sepia ink oligopeptide induces apoptosis in prostate cancer cell lines via caspase-3 activation and elevation of Bax/Bcl-2 ratioFangfang Huang
School of Food science and Pharmacy, Zhejiang Provincial Key Engineering Technology Research Center of Marine Biomedical Products, Zhejiang Ocean University, Zhoushan 316000, China
Mar Drugs 10:2153-65. 2012..Moreover, the Bax/Bcl-2expression ratio was increased. Concurrently, the expression of caspase-3 was upregulated. These data support our hypothesis that SIO has anticarcinogenic properties...
- A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1Seval Turkmen
Institut fur Medizinische Genetik, Charité CVK, Berlin, Germany
Genes Chromosomes Cancer 50:389-96. 2011..Moreover, it suggests that members of the BCL2 anti-apoptosis gene family other than BCL2 itself might also be involved in lymphoma...
- Blood myeloid dendritic cells from HIV-1-infected individuals display a proapoptotic profile characterized by decreased Bcl-2 levels and by caspase-3+ frequencies that are associated with levels of plasma viremia and T cell activation in an exploratory stStephanie M Dillon
Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
J Virol 85:397-409. 2011....
- Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorderTakuji Uemura
Laboratory of Cellular and Molecular Pathophysiology, Centre for Addiction and Mental Health Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Bipolar Disord 13:41-51. 2011..We sought to evaluate the impact of this variant on ICH in BD...
- A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse casesShaily Malik
Cellular and Molecular Neuroscience, National Brain Research Center, Manesar, Gurgaon, Haryana, India
PLoS ONE 6:e18116. 2011..We have also showed for the first time that PDGF-BB can protect against simultaneous exposure of Tat and morphine, strengthening its role as a neuroprotective agent that could be considered for therapeutic intervention...
- Human immunodeficiency virus type 1 Tat protein modulates cell cycle and apoptosis in Epstein-Barr virus-immortalized B cellsEva Colombrino
Department of Oncology and Surgical Sciences, Section of Oncology, University of Padova, Padua, Italy
Exp Cell Res 295:539-48. 2004....
- Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast cancer cellsHwan Kim
Department of Pathology, College of Medicine, Hanyang University, Seongdong Gu, Seoul, Republic of Korea
Breast Cancer Res Treat 112:287-96. 2008..In this regard, inactivation of Id-1 may provide a potential therapeutic strategy leading to inhibition of breast cancer progression and anti-cancer drug resistance...
- Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cellsD Trisciuoglio
Experimental Chemotherapy Laboratory, Experimental Oncology Department, Regina Elena Cancer Institute, Rome, Italy
Cell Death Differ 18:1024-35. 2011..Finally, we found that the mechanism by which bcl-2 regulates HIF-1-mediated VEGF expression does not require BH1 and BH2 domains, and it is independent of antiapoptotic and prosurvival function of bcl-2...
- Bcl-2 targets protein phosphatase 1 alpha to BadV Ayllon
Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Campus de Cantoblanco, Madrid, Spain
J Immunol 166:7345-52. 2001..Disruption of Bcl-2/PP1alpha association strongly decreased Bcl-2 and Bad-associated phosphatase activity and formation of the trimolecular complex. These results suggest that Bcl-2 targets PP1alpha to Bad...
- Comparison of benign keratoses using p53, bcl-1, and bcl-2Christine J Ko
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
J Cutan Pathol 32:356-9. 2005..Keratinocyte bcl-2 staining was significantly higher in SKs compared with the other two keratoses. Bcl-2 may be increased in SKs as an anti-apoptotic mechanism...
- [Effect of combined therapy with Chinese drug and narrow broad ultraviolet B on Bcl-2, caspase-3 and survivin in skin lesion with psoriasis vulgaris]Lan Ying Qin
Department of Dermatology, Cangzhou People s Hospital, Hebei
Zhongguo Zhong Xi Yi Jie He Za Zhi 30:706-9. 2010..To reveal the possible role of combined therapy with Chinese drug and narrow broad ultraviolet B (NB-UVB) on keratinocytes apoptosis in skin lesion of psoriasis vulgaris (PV)...
- Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosisW S May
Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231
J Biol Chem 269:26865-70. 1994..These findings strongly support a role for activated PKC in growth factor-induced Bc12 alpha phosphorylation as well as suppression of apoptosis...
- Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemiaMilvia Casato
Department of Clinical Medicine, University of Rome La Sapienza, Rome, Italy
Blood 99:2259-61. 2002..Further studies of HCV-infected patients with and without type II cryoglobulinemia are required to determine the prevalence and possible physiologic and/or pathophysiologic significance of these findings...
- Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organizationNhan L Tran
Cancer Biology Graduate Program, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
J Biol Chem 277:32905-14. 2002..We propose that N-cadherin homophilic adhesion can initiate anti-apoptotic signaling, which enhances the Akt cell survival pathway in metastatic cancer...
- Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cellsQin Xu
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
J Clin Endocrinol Metab 90:953-61. 2005....
- Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibitionConstantine S Mitsiades
Department of Medical Oncology, Dana Farber Cancer Institute, Mayer Building, Room M555, 44 Binney Street, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 92:4845-52. 2007..The Bcl-2 family of proteins regulates apoptosis in various models and may represent a promising therapeutic target in human malignancies...
- Developmental patterns of caspase-3, bax and bcl-2 proteins expression in the human spinal gangliaKatarina Vukojevic
Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, 21000 Split, Croatia
J Mol Histol 39:339-49. 2008..While apoptosis might control cell number, bcl-2 could act in suppression of apoptosis and enhancement of cell differentiation...
- Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motifJingzhen Ding
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126, USA
J Biol Chem 285:28749-63. 2010..As expected, both kinds of mutation abolished Bcl-2-mediated inhibition of Bax oligomerization in detergent micelles. Therefore, Bcl-2 binds Bax through two interdependent interfaces to inhibit the pro-apoptotic oligomerization of Bax...
- Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosisG Zauli
Institute of Human Anatomy, University of Ferrara, Italy
Cancer Res 53:4481-5. 1993....
- Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilizationTapas K Sengupta
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 279:10855-63. 2004....
- Parkin mono-ubiquitinates Bcl-2 and regulates autophagyDong Chen
Laboratory of Molecular Neuropathology, School of Life Sciences, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui 230027, China
J Biol Chem 285:38214-23. 2010..Moreover, overexpression of parkin enhances the interactions between Bcl-2 and Beclin 1. Our results provide evidence that parkin mono-ubiquitinates Bcl-2 and regulates autophagy via Bcl-2...
- Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family membersMichael Certo
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
Cancer Cell 9:351-65. 2006..Our data allow us to distinguish a cellular state we call "primed for death," which can be determined by BH3 profiling and which correlates with dependence on antiapoptotic family members for survival...
- Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancerYasmine Nadler
Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Breast Cancer Res 10:R35. 2008....
- Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family membersTristan Gallenne
Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 892, Département de Recherche en Cancérologie, F 44035 Nantes, Cedex 01, France
J Cell Biol 185:279-90. 2009..Thus, Puma is competent to trigger Bax activity by itself, thereby promoting cellular dependence on prosurvival Bcl-2 family members...
- Bcl-2 overexpression attenuates SP600125-induced apoptosis in human leukemia U937 cellsDong Oh Moon
Faculty of Applied Marine Science, Cheju National University, Jeju Special Self Governing Province 690 756, South Korea
Cancer Lett 264:316-25. 2008..These data provide important mechanistic insights related to Bcl-2-mediated resistance to SP600125-induced apoptosis, and induction of G2/M phase arrest and endoreduplication...
- The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)Cong Bao Kang
Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637511, Singapore
FEBS Lett 579:1469-76. 2005..Here, we investigated the molecular interaction between FKBP38 and Bcl-2, and demonstrated that Bcl-2 interacts with FKBP38 through the unstructured loop, and the interaction appears to regulate phosphorylation in the loop of Bcl-2...
- Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2Pedro Jose Real
Unidad de Genetica Molecular and Servicio de Oncologia Medica, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
Cancer Res 64:7947-53. 2004..Consistently, HER2 blockade led to YC137 resistance. These data provide evidence for the selective killing of tumor cells by YC137 and represent the first example of in vitro selection of cancer cells refractory to a Bcl-2 inhibitor...
- Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1M Chiara Maiuri
INSERM U848, Villejuif, France
EMBO J 26:2527-39. 2007..BH3-only proteins and pharmacological BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin-1 and Bcl-2 or Bcl-X(L)...
- The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptorYi Ping Rong
Departments of Medicine and Pharmacology, Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 106:14397-402. 2009..By inhibiting proapoptotic Ca(2+) signals at their point of origin, the Bcl-2 BH4 domain has the facility to block diverse pathways through which Ca(2+) induces apoptosis...
- The bcl2 -938CC genotype has poor prognosis and lower survival in renal cancerHiroshi Hirata
Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California 94121, USA
J Urol 182:721-7. 2009..Therefore, we investigated the polymorphism at the bcl2 -938C/A site and its effects on clinical characteristics in patients with renal cell carcinoma...
- Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damageHernando Lopez
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
J Biol Chem 285:15016-26. 2010..These results suggest that the loss/inactivation of Mcl-1 in conjunction with an induced Noxa/Bcl-xL interaction may serve as a trigger for mitochondrial dysfunction during DNA damage-induced apoptosis...
- The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathwayT Roumier
Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
Cell Death Differ 9:1212-9. 2002..In conclusion, it appears that Vpr induces apoptosis through a caspase-independent mitochondrial pathway...
- Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cellsHongyan Gu
Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, P O Box 209, 24 Tongjia Xiang, 210009 Nanjing, Jiangsu, China
J Cancer Res Clin Oncol 135:1777-82. 2009..In this study, we investigated the correlation between p53 and bcl-2 in gambogic acid (GA)-induced apoptosis...
- Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2Ye Liang
The Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Mol Pharmacol 61:142-9. 2002..Caspase 3-mediated Bcl-2 cleavage therefore plays an important role in the potentiation by Bcl-2 of NCS-induced apoptosis...
- Resistance to chemotherapy-induced apoptosis via decreased caspase-3 activity and overexpression of antiapoptotic proteins in ovarian cancerXiaokui Yang
Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, PR China
J Cancer Res Clin Oncol 130:423-8. 2004....
- Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by GastrinsHong He
Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
Cell Signal 20:83-93. 2008..The findings offer potential targets for blocking the growth-stimulating effects of these gastrins...
- Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cellsH Duan
Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
Oncogene 27:6720-8. 2008..This study reveals a new aspect of the regulatory role of the IgH 3' enhancers on bcl-2 transcription in t(14;18) lymphomas...
- Nuclear partners of Bcl-2: Bax and PMLR W M Hoetelmans
Department of Surgery, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
DNA Cell Biol 23:351-4. 2004..These data show that binding of Bcl-2 with structurally and functionally related proteins extends to the nucleus, emphasizing its pivotal role in Bcl-2-mediated actions...
- Cell-cycle-associated markers and clinical outcome in human epithelial cancers: a tissue microarray studyI Abdulkader
Department of Pathology, School of Medicine, Clinical University Hospital, 15706 Santiago de Compostela, Spain
Oncol Rep 14:1527-31. 2005..We found that in most common epithelial cancers, regardless of origin, Bcl-2 appears to be the key biological factor influencing clinical behaviour...
- Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic IndexGrace M Callagy
Cancer Genomics Program, Department of Oncology, Hutchison Medical Research Council Research Centre, University of Cambridge, United Kingdom
Clin Cancer Res 12:2468-75. 2006..We validated the results in an independent series...
- BCL-2 expression is prognostic for improved survival in non-small cell lung cancerDaniel J Renouf
Division of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
J Thorac Oncol 4:486-91. 2009..We used a large patient population to identify immunohistochemical biomarkers to enable improved prognostication in patients with non-small cell lung carcinoma (NSCLC)...
- Bcl-2 associates with the ras-related protein R-ras p23M J Fernandez-Sarabia
Onyx Pharmaceuticals, Richmond, California 94806
Nature 366:274-5. 1993..These results provide evidence of a putative component of a signal transduction pathway involved in the regulation of apoptosis...
- Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cellsK J Sastry
Department of Veterinary Sciences, University of Texas MD Anderson Cancer Center, Bastrop 78602, USA
Oncogene 13:487-93. 1996..While these results support reports in the literature of an active role for tat in inducing cell death in HIV-infected individuals, they point to a new mechanism involving Tat-mediated modulation of bcl-2 and bax...
- Modulation of endoplasmic reticulum calcium pump by Bcl-2T H Kuo
Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Oncogene 17:1903-10. 1998..Since high lumenal Ca2+ concentration of ER is essential for normal cell functions, the results suggest that Bcl-2 preserves the ER Ca2+ store by upregulating SERCA gene expression as well as by a possible interaction with the pump...
- Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulationG Vairo
The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Mol Cell Biol 20:4745-53. 2000..Hence, Bcl-2 appears to retard cell cycle entry by increasing p27 and p130 levels and maintaining repressive complexes of p130 with E2F4, perhaps to delay E2F1 expression...
- Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screeningI J Enyedy
Structural Biology and Cancer Drug Discovery Program, Lombardi Cancer Center and Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Road, Washington, DC 20007, USA
J Med Chem 44:4313-24. 2001..Our results suggest that the structure-based computer screening strategy employed in the study is effective for identifying novel, structurally diverse, nonpeptide small-molecule inhibitors that target the BH3 binding site of Bcl-2...
- Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viabilityGael G McGill
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cell 109:707-18. 2002..This linkage helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well-known treatment resistance of melanoma...
- The Bcl2 family: regulators of the cellular life-or-death switchSuzanne Cory
The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
Nat Rev Cancer 2:647-56. 2002..Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches...
- BCL-x(L) and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinasesCourtney Greider
Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, TN 37232, USA
Oncogene 21:7765-75. 2002..Our results suggest that one possible mechanism by which BCL-x(L) and BCL2 delay cell cycle entry may be the inhibition of Myc activity through the elevation of p27...
- BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiationLoralee Haughn
Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Biol Chem 278:25158-65. 2003..These effects are associated with differential regulation of Raf-1 expression, perhaps involving the previously identified interaction between BCL-2-BH4 and the catalytic domain of Raf-1...
- Intronic single-nucleotide polymorphisms in Bcl-2 are associated with chronic obstructive pulmonary disease severityMakoto Sata
Department of Cardiology, Pulmonology and Nephrology, Course of Internal Medicine and Therapeutics, Yamagata University School of Medicine, Yamagata, Japan
Respirology 12:34-41. 2007..The aim of this study was to investigate the genetic association of Bcl-2 gene with the level of lung function, that is, the severity, of COPD...
- Bcl2 -938C/A polymorphism carries increased risk of biochemical recurrence after radical prostatectomyHiroshi Hirata
Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, USA
J Urol 181:1907-12. 2009..We investigated several polymorphisms related to the cell cycle and apoptosis, and their role in biochemical failure after radical prostatectomy...
- Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic functionI A Ciechomska
Department of Biochemistry, University of Cambridge, Cambridge, UK
Oncogene 28:2128-41. 2009..Hence, although Beclin-1 contains a BH3-only motif typical of pro-apoptotic proteins, it is a negligible modulator of Bcl-2's anti-apoptotic function...
- Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humansGiacomo Salvadore
Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 66:804-7. 2009..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation...
- BCL-2, BAX and P53 expression profiles in endometrial carcinoma as studied by real-time PCR and immunohistochemistryOurania Porichi
Department of Virology, Papanikolaou Research Center of Oncology and Experimental Surgery, Aghios Savvas, Regional Anticancer Oncology Hospital of Athens, 171 Alexandras Ave, 115 22, Athens, Greece
Anticancer Res 29:3977-82. 2009..Apoptotic genes regulate apoptosis by the action of their pro- and antiapoptotic products. Among the most important proteins are p53 and Bcl-x family proteins...
- Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U-rich element-binding factor 1 (AUF1)Daniella Ishimaru
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 285:27182-91. 2010..Based on our findings, we propose a model that illustrates the opposing roles of nucleolin and AUF1 in regulating bcl-2 mRNA stability...
- IRGM is a common target of RNA viruses that subvert the autophagy networkIsabel Pombo Gregoire
Universite de Lyon, Lyon, France
PLoS Pathog 7:e1002422. 2011..Our work reveals an unexpected role of IRGM in virus-induced autophagy and suggests that several different families of RNA viruses may use common strategies to manipulate autophagy to improve viral infectivity...
- Ultrastructural localization of bcl-2 proteinP Monaghan
Department of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, UK
J Histochem Cytochem 40:1819-25. 1992....
- Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphomaM Seto
Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
EMBO J 7:123-31. 1988..5 h half-life, the Bcl-2--Ig gene revealed an inappropriately high rate of transcription for a mature B-cell. This indicates the translocated Bcl-2 allele has escaped normal control mechanisms...
- Bcl-2 targets the protein kinase Raf-1 to mitochondriaH G Wang
The Burnham Institute, Program on Apoptosis and Cell Death Research, La Jolla, California 92037, USA
Cell 87:629-38. 1996..Bcl-2 can therefore target Raf-1 to mitochondrial membranes, allowing this kinase to phosphorylate BAD or possibly other protein substrates involved in apoptosis regulation...
- Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2F Shibasaki
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 386:728-31. 1997..We propose that the ability of Bcl-2 to block NF-AT signalling is due to the sequestering of active calcineurin to the same domain of Bcl-2 which associates with Rad-1 (ref. 5), and that calcineurin may act in Bcl-2-regulated functions...
- BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activityJ Zha
Howard Hughes Medical Institute, Department of Medicine and Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 272:24101-4. 1997..These results establish a critical role for a BH3 domain within BAD and provide evidence that BAD may function as a death ligand whose pro-apoptotic activity requires heterodimerization with BCL-XL...
- The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition poreE Jacotot
Centre National de la Recherche Scientifique, F 94801 Villejuif, France
J Exp Med 191:33-46. 2000..Hence, Vpr induces apoptosis via a direct effect on the mitochondrial PTPC...
- Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinasesX Deng
University of Florida Shands Cancer Center, Gainesville, FL 32610 0232, USA
Proc Natl Acad Sci U S A 97:1578-83. 2000..In addition, although the mechanism of regulation of Bcl2 by phosphorylation is not yet clear, our results indicate that phosphorylation may functionally stabilize the Bcl2-Bax heterodimerization...
- A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activityS Tagami
Department of Medical Genetics, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Japan
Oncogene 19:5736-46. 2000..These results suggest that RTN family proteins can modulate the anti-apoptotic activity of Bcl-XL and Bcl-2 by binding with them and can change their localization to the ER...
- Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikisH Puthalakath
The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O Royal Melbourne Hospital, 3050 Vic, Australia
Science 293:1829-32. 2001..Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures...
- Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphateRui Chen
Department of Medicine, Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, USA
J Cell Biol 166:193-203. 2004..We suggest that this functional interaction of Bcl-2 with InsP3Rs inhibits InsP3R activation and thereby regulates InsP3-induced calcium release from the ER...
- JNK is associated with Bcl-2 and PP1 in mitochondria: paclitaxel induces its activation and its association with the phosphorylated form of Bcl-2Laetitia Brichese
Universite Paul Sabatier, Toulouse, France
Cell Cycle 3:1312-9. 2004....
- The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMAPierre Francois Cartron
INSERM U601, 9 quai Moncousu, 44035 Nantes Cedex 035, France
Mol Cell 16:807-18. 2004..Thus, a specific interaction between Bax Halpha1 and their BH3 domains allows Bid and PUMA to function as "death agonists" of Bax, whereas Bad recruits Bax activity through a distinct pathway...
- Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteinsSimon N Willis
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Genes Dev 19:1294-305. 2005..The finding that different prosurvival proteins have selective roles has notable implications for the design of anti-cancer drugs that target the Bcl-2 family...
- miR-15 and miR-16 induce apoptosis by targeting BCL2Amelia Cimmino
Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA
Proc Natl Acad Sci U S A 102:13944-9. 2005..BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors...
- Douglas R Green; Fiscal Year: 2016..Successful completion of the proposed work will reveal fundamental new processes in the control of cell life and death. ..
- Mechanisms of Hypothermic Protection from Ischemia/Reperfusion Cardiac InjuryKimm J Hamann; Fiscal Year: 2010....
- Shai Shaham; Fiscal Year: 2016..Together, these studies should not only inform us about the process of LC death, but may yield important clues and reagents as to the etiology of polyQ-dependent neurodegenerative disease. ..
- Modulation of Apoptosis by IRF-4 in EBV transformationLuwen Zhang; Fiscal Year: 2010..These experiments may identify the apoptosis. These experiments may identify critical mechanisms that IRF-4 uses to prevent apoptosis in EBV-transformed cells. ..
- Signaling Cell Death from the Endoplasmic ReticulumScott A Oakes; Fiscal Year: 2013..This projects sets out to define how cellular stress normally leads to apoptosis and what goes wrong with this process in cancer-in the hopes of finding new therapeutic targets through which to kill tumor cells. ..
- FDRC1 AND FOLLICULAR DENDRITIC CELL SIGNALING PATHWAYSEdward A Clark; Fiscal Year: 2013..The proposed studies may also contribute to understanding of how E2 and OPG contribute to the development of inflammatory immune responses. ..
- J Marie Hardwick; Fiscal Year: 2014..Therefore, we will delineate the mechanisms that explain how Bcl-xL regulates mitochondrial dynamics and enhances neuronal activity in healthy neurons. ..
- Rona G Giffard; Fiscal Year: 2016..Overall this proposal exams a novel hypothesis: that miRNAs act as master regulators of chaperones and BCL2 family members influencing Ca2+ homeostasis, mitochondria-ER crosstalk, and outcome after cerebral ischemia. ..
- Regulation of mitochondrial oxidative stress by Bcl-2 family proteinsDANIEL LINSEMAN; Fiscal Year: 2011..PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page ..
- Mcl-1 as an essential regulator of cardiac mitochondrial functionAsa B Gustafsson; Fiscal Year: 2013..This project will provide important new insights into mitochondrial function in cardiac myocytes and how mitochondrial dysfunction contributes to development of cardiovascular disease. (End of Abstract) ..
- Nika N Danial; Fiscal Year: 2016..The studies described in this proposal may lead to identification of a new therapeutic target in diabetes. ..
- The Cyto-Protective Role of Hexokinase II During Metabolic StressJONATHAN MICHAEL GALL; Fiscal Year: 2012..The proposed studies will provide molecular insights into the mechanism of renal cell death and may promote the development of therapeutic interventions for treating acute, ischemic renal failure. ..
- Bid regulation of cutaneous photodamage responsesLaura Timares; Fiscal Year: 2010..The results from these studies may uncover a new mechanism for controlling cancer and a possible new target for diagnostic or therapeutic applications. ..
- Reactivating Apoptosis in Refractory Cancer by Selective Targeting of MCL-1Michelle Stewart; Fiscal Year: 2010....
- Mechanisms of Stress Induced Apoptosis in T-CellsDouglas R Green; Fiscal Year: 2011..In this integrated approach to the problem of p53 function in apoptosis, we will elucidate the roles of p53 in the context of stress-induced apoptosis in mature and developing T cells. ..
- Xiao Kun Zhang; Fiscal Year: 2014..Our proposed studies are anticipated to identify an important new survival signaling pathway in cancer cells, which may serve as a new drug target. ..
- IL3 GROWTH FACTOR SIGNALINGWilliam Stratford May; Fiscal Year: 2010....
- Steven C Borkan; Fiscal Year: 2016....
- Junxuan Lu; Fiscal Year: 2014..These multiple targeting activities plus published work supporting anti- angiogenesis activity provide strong rationale for testing the efficacy of PGG for prostate cancer chemoprevention. ..
- ERBB4 in the Normal and Neoplastic BreastFrank E Jones; Fiscal Year: 2013....
- Il-7 receptor signaling in lymphopoiesisMotonari Kondo; Fiscal Year: 2010..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor, which drive specific steps in lymphocyte development, and to determine the genes involved in this process. ..
- Apoptosis Control by Bcl-2 Family MembersCraig B Thompson; Fiscal Year: 2012....
- NIH Director's Pioneer AwardJunying Yuan; Fiscal Year: 2009..No Abstract provided ..
- Shu Ichi Matsuzawa; Fiscal Year: 2015....
- Karen M Vasquez; Fiscal Year: 2016....
- Maurizio Pellecchia; Fiscal Year: 2014..The development of small molecule Mcl-1 inhibitors represent a promising route for the development of more effective combination therapies for the treatment of NSCLC. ..
- Comparative Mechanisms of Genomic InstabilityKaren M Vasquez; Fiscal Year: 2010..These discoveries should begin to unravel the pathogenesis of diseases that are caused by genomic instability, and ultimately to the development of new approaches for treatment and prevention. ..
- Apoptosis and Trophoblast FusionNEAL STEWART ROTE; Fiscal Year: 2010..We will investigate those correlations by specifically inhibiting these proteins using peptide inhibitors and gene silencing. Additional studies will evaluate the role of signal transduction through NFB. ..
- Heat Shock-Induced ApoptosisShawn B Bratton; Fiscal Year: 2012..Thus, it is anticipated that the work proposed herein will significantly improve our understanding of how heat shock works in the clinic and may shed light on new pathways that can be exploited therapeutically in the future. ..
- NLR Family Proteins: Mechanisms and RegulationJohn C Reed; Fiscal Year: 2012..The proposed project is relevant to several diseases with unmet medical needs, including autoimmunty, chronic inflammation, allergy, infection, and vaccines. ..
- TARGETS OF AMINO ACID RESTRICTION IN PROSTATE CANCERGary G Meadows; Fiscal Year: 2009..This research could serve as the basis for future development of more specific antimetastatic, anti-invasive, apoptosis-based therapies for human prostate cancer. ..
- Molecular Characterization of Neural Stem Cell ApoptosisKEVIN AARON ROTH; Fiscal Year: 2012....
- FUNCTION OF THE BCL-2 PROTEINDONALD EWERT; Fiscal Year: 1993..These studies can help to define the molecular basis of B cell malignancy...
- PP2A B-beta a novel apoptosis regulatorJosé Carlos Crispín; Fiscal Year: 2013..Moreover, it represents a conceptual breakthrough in our understanding of the regulation of PP2A in a discrete function. ..
- P53 TRAFFICKING DURING CELL CYCLEMichael Clarke; Fiscal Year: 2000..These studies will give insight into the molecular mechanism by Bcl-2 and Myc modulate p53 functions. ..
- Peixin Yang; Fiscal Year: 2016....
- Anand K Iyer; Fiscal Year: 2016....
- Robert M Friedlander; Fiscal Year: 2014..Finally, we will determine if posttranslational modification of Rip2 is required for epigenetic gene regulation and subsequent neuronal death in HD using HD mice lacking expression of Rip2. ..
- Protein Nitration in the PlacentaLeslie Myatt; Fiscal Year: 2012....
- ERIC KIRK LAU; Fiscal Year: 2014..abstract_text> ..
- Nanoelectrode arrays for study of the molecular mechanisms, triggers, and inhibitPeter J Burke; Fiscal Year: 2012..A high throughput technology to monitor P in mitochondria will allow further studies of these issues in cancer biology. ..
- Targeting ATAP-mediated Apoptosis in Treatment of Prostate CancerZelin Sheng; Fiscal Year: 2013....
- David W Kamp; Fiscal Year: 2016..g. asbestos, cigarette smoke, air-borne particulate matter etc). ..
- The in vivo role of the mitochondrial p53 cell death programUTE MARTHA MOLL; Fiscal Year: 2013..This is the thrust of this proposal. Furthermore, this proposal aims at gaining more mechanistic insight into how p53 works at the mitochondria to permeabilize these organelles. ..
- GM1 at the ER-mitochondrion microdomains regulates Ca2+ signaling and apoptosisALESSANDRA D apos AZZO; Fiscal Year: 2010..This knowledge is essential for designing new therapies for children with GM1-gangliosidosis and possibly those with other GSL storage diseases. ..
- Molecular Targeting of the Survivin Pathway in CancerDario C Altieri; Fiscal Year: 2010..This work will provide a mechanistic foundation for the validation and further development of molecular antagonists of the survivin pathway for novel cancer therapeutics in humans. ..
- Bax function in apoptosisDONALD DAVID NEWMEYER; Fiscal Year: 2013..We also want to understand how mutations of Opa1 that occur in patients with a disease called "Autosomal Dominant Optic Atrophy" can cause hereditary loss of vision later in life. ..
- Mitochrondrial Regulation of ApoptosisTomomi Kuwana; Fiscal Year: 2013..Mapping the distribution of Bax along the edge of the pores will enable us to determine whether Bax pores are mainly lipidic or proteinaceous. ..
- GM1 as apoptotic signal in neurodegenerative GM1-gangliosidosisALESSANDRA D apos AZZO; Fiscal Year: 2010..The proposed studies may also reveal basic biological processes controlled by the molecules that are accumulated in GM1. This knowledge is essential for designing new therapies for children with GM1 and possibly those with other LSDs. ..
- David W Kamp; Fiscal Year: 2016..g. asbestos, cigarette smoke, particulate matter etc). ..
- Subcellular Regulation of Autophagic Flux in Cardiomyocytes and the HeartRoberta A Gottlieb; Fiscal Year: 2012..Its role in the heart is poorly understood. Since infection and inflammation increase autophagy and exacerbate heart failure, we hypothesis that autophagy contributes to injury in this context. ..
- MAVS protein: A role of mitochondria in innate immunity and cardioprotectionKirk Peterson; Fiscal Year: 2013..abstract_text> ..
- Mechanisms of Mutant SOD 1-Mediated Mitochondria Toxicity in the Spinal Cord of ADavide Trotti; Fiscal Year: 2012..They play a pivotal role in maintaining neuronal cell alive. A pathology-driven impairment of these organelles may shift the balance between life and death and lead to neuronal degeneration. ..
- Atg6 in Protection Against Insulin ResistanceNICHOLAS PERRY GREENE; Fiscal Year: 2012..In these studies we will elucidate the role of mitochondrial stress-induced autophagy in the onset of insulin resistance. ..
- Astar Winoto; Fiscal Year: 2014..abstract_text> ..
- Paul Dent; Fiscal Year: 2014..As Lapatinib is already FDA approved, the successful completion of the studies proposed in this application would rapidly facilitate phase I translation of the drug combination in patients with recurrent breast cancer. ..
- Molecular mechanism of ADNF and ADNP peptides in prevention of mitochondrial dysfYoussef Sari; Fiscal Year: 2010..This will provide information in finding therapeutic ways for the treatment of fetal alcohol exposure. ..
- Mitochondrial ion channels in hypoxic neuronsElizabeth Ann Jonas; Fiscal Year: 2013..We hypothesize that in the setting of brain ischemia, such channel activity leads to cell death in the brain and that this death can be prevented by a pharmacological inhibitor of BCL-2-induced mitochondrial ion channels. ..
- GR SCOTT BUDINGER; Fiscal Year: 2015..Our studies will allow us to predict whether these agents are likely to modulate the cardiovascular response to inhaled particles. ..
- Role of leukemia-associated protein MLF1 in apoptotic cell deathALAN ALI POURPAK; Fiscal Year: 2011..Generation of an Npm-MLF1 mouse model of MDS/AML pathogenesis would serve as an experimental tool to assess the effectiveness of both existing as well as novel antileukemia therapies. ..
- Role of mitochondria in cardiac protectionPeipei Ping; Fiscal Year: 2010..These studies will provide novel and mechanistic information to aid our understanding of mitochondrial function in myocardial ischemic injury. ..
- ANIL KUMAR JAISWAL; Fiscal Year: 2014..The studies may also provide the basis for further analysis of identified targets (cis- and trans-elements) that could ultimately allow us to increase the chemoprotective capacity of cells. ..
- Molecular Regulation of Erythroid DifferentiationMin Chen; Fiscal Year: 2013..The proposed studies may lead to better understanding of the pathogenesis of hemotological disorders associated with defective erythroid maturation. ..
- Prolactin as a Growth Factor in Breast CancerNira Ben-Jonathan; Fiscal Year: 2013..The long term goal is to establish FDA-approved, long acting dopamine agonists as suppressor or PRL secretion, resulting in increased efficacy of chemotherapeutic agents in breast cancer patients. ..
- Cornelia M Weyand; Fiscal Year: 2016..The studies will include vaccinating RA patients with an influenza vaccine to test whether they can build sufficient T cells to be protected from infection. ..
- Endocrine resistance in breast cancerROBERT R CLARKE; Fiscal Year: 2013..Aim 3: We will build and test interactive in silico models of how XBP1, RELA, ER, and BCL2 signal to affect breast cancer cell survival in the context of UPR and endocrine responsiveness. ..
- New Molecular and Cellular Mechanisms of GlaucomaAndrei Surguchov; Fiscal Year: 2013..The purpose of this proposal is to examine how 3-synuclein affects prosurvival/prodeath signaling and how it is implicated in MMP-9 regulation in glaucoma. ..
- Bethany B Moore; Fiscal Year: 2016..via which periostin and TGFb regulate each other and the function of lung mesenchymal cells Aim 4) To determine whether periostin levels in plasma or bronchoalveolar lavage fluid of IPF patients correlate with disease progression ..
- Lipidoid Nanoparticles with Simultaneous Multi-Gene Regulation for Cancer TherapyYizhou Dong; Fiscal Year: 2013..It is my hope that this platform will enable scientists in the future to fine-tune the combination of siRNA and pDNA for specific disease treatment in specific individuals, thereby advancing the field of personalized medicine. ..
- IRF1 regulation of BCL2 family members determines breast cancer cell fateJESSICA LEA ROBERTS; Fiscal Year: 2013..The studies will also determine whether induction of IRF1 signaling can improve responsiveness to AEs when combined with a BCL2 inhibitor. ..
- W Mark Saltzman; Fiscal Year: 2016..In all of our approaches, we rely on materials that are already acceptable to the FDA in clinical settings;therefore, our results in animal models will be ready for translation into clinical practice. ..
- Gyorgy Hajnoczky; Fiscal Year: 2016..Tumors are commonly resistant to cell killing agents, and our work might show an Achilles'heel of hepatocarcinoma. ..
- CHRISTINE ANN CARTWRIGHT; Fiscal Year: 2015..Exploitation of these multiple functions could be used to develop new and more powerful and selective strategies for treatment of human colon cancer. ..
- Zhenfeng Duan; Fiscal Year: 2014..and cytotoxic drugs for maximum cell-kill effect. ..
- REBECCA I GOLDSTEIN; Fiscal Year: 2016....
- Targeting BAX Oligomerization in Hematologic DiseaseEvripidis Gavathiotis; Fiscal Year: 2013..abstract_text> ..
- Cell Models for Alzheimer's disease (AD): Lipids and Related Signaling PathwaysGrace Y Sun; Fiscal Year: 2012..These collaborative studies should identify novel strategies to control chronic inflammation and neurodegeneration in AD. ..
- David Kozono; Fiscal Year: 2016..In so doing, I hope to provide rationale for testing proteasome and/or USP9X inhibition in Phase I/II trials, and to identify biomarkers for patient selection. ..
- Rheem D Medh; Fiscal Year: 2015..Studies proposed here will unravel the complex pathways that govern leukemic cell proliferation, differentiation and apoptosis so that more effective therapeutic strategies may be developed. ..
- Anthony G Letai; Fiscal Year: 2016..Moreover, using in vitro co-culture systems, we will study the efficacy and mechanisms of drugs intended to interrupt CLL interactions with stromal cells. Our goal is to identify which CLL patients will most benefit from such therapies. ..
- Antibody directed delivery of short interfering RNA for the treatment of ovarianMaria Corinna Palanca-Wessels; Fiscal Year: 2013..Additionally, she will utilize the outstanding resources offered by both the Fred Hutchinson Cancer Research Center and the University of Washington to foster her career development. ..
- JACQUES EDUARDO NOR; Fiscal Year: 2015..Our research team is fully committed to the development of a mechanism- based therapy that will enhance the survival and quality of life of patients with adenoid cystic carcinoma. ..
- Role of B-cell oncogenes and microRNA-34 in B-lymphopoiesis and neoplasiaDinesh S Rao; Fiscal Year: 2013..Hence, these studies have a direct relevance to public health and most importantly, to patients living with these diseases. ..
- James W Rocco; Fiscal Year: 2015..It thus will support development of intensified treatments for those at high risk and of treatments with less morbidity for those at low risk. ..
- GARY I YELLEN; Fiscal Year: 2016..Understanding this pathway should yield valuable clues for translating this potent anticonvulsant effect of metabolism into improved therapies for the many individuals with intractable epilepsy. ..
- NLRP1 activation induces deletion of hematopoietic progenitor cellsBEN ADAM CROKER; Fiscal Year: 2013..C. characterise the role of NLRP1 in hematopoietic stem and progenitor cells during hematopoietic stress induced by infection and chemotherapy, to understand beneficial and pathological roles for NLRP1 activation ..
- Chunhong Yan; Fiscal Year: 2014....
- Craig M Coopersmith; Fiscal Year: 2016..Understanding how sepsis- induced gut apoptosis alters overall intestinal integrity may therefore have significant therapeutic implications in a disease that is the most common killer in intensive care units. ..
- CLARE MARIE ADAMS; Fiscal Year: 2014..The education, training, and career development program outlined in this proposal will support my goal of becoming an independent investigator in cancer biology. ! ..
- Suzanne C Hoppins; Fiscal Year: 2015..abstract_text> ..
- Bcl-2 selective inhibitors: development and application to cancer treatmentChengguo Xing; Fiscal Year: 2009....
- Bcl-2, A Key Factor for Dentinogenesis and Tooth Damage RepairWenjian Zhang; Fiscal Year: 2010..It is expected to generate new interventions to preserving the vitality and functions of teeth injured by infections or trauma, and contributing to fabricated teeth via bioengineering. ..
- Bc12 regulates osteoclast survivalJunro Yamashita; Fiscal Year: 2010..Bcl2 could be a therapeutic target to suppress osteoclasts. This project will clarify the Bcl2 regulation of osteoclastogenesis via osteoclast progenitors. ..
- Molecular Adaptation of Hypoxia in Oxygen Sensing CellsDavid Millhorn; Fiscal Year: 2007..This information may be helpful for developing strategies and targets for treating hypoxia-associated diseases and injury. ..
- The BCL-2 Homologues of Gamma HerpesvirusesJ Marie Hardwick; Fiscal Year: 2006..In Aim 3, the expression patterns of BHRF1 and BALF1 during virus infections will be explored by inserting tags into the their reading frames within the Epstein-Barr virus genome. ..
- BC1-2 REARRANGEMENTS IN CLLLouise Showe; Fiscal Year: 1992..These studies can help to define the molecular basis of the pathogenesis of CLL...
- Transport and Insertion of Outer Membrane ProteinsSangita Sinha; Fiscal Year: 2009..This application aims to investigate atomic details of the mechanism by which 3-herpesviruses inhibit autophagy, providing a better understanding of 3-herpesviral pathogenicity. ..