betaine homocysteine methyltransferase

Summary

Gene Symbol: betaine homocysteine methyltransferase
Description: betaine--homocysteine S-methyltransferase
Alias: BHMT1, HEL-S-61p, betaine--homocysteine S-methyltransferase 1, epididymis secretory sperm binding protein Li 61p
Species: human

Top Publications

  1. ncbi Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats
    Cindy D Davis
    US Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 133:2907-14. 2003
  2. ncbi Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD)
    Sandy Slow
    Biochemistry Unit, Canterbury Health Laboratories, P O Box 151, Christchurch, New Zealand
    Exp Toxicol Pathol 58:285-90. 2007
  3. pmc Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically
    Joan Oliva
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St Torrance, CA 90502, USA
    World J Gastroenterol 15:705-12. 2009
  4. ncbi Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease
    Ilan S Weisberg
    Department of Human Genetics, McGill University Health Center Montreal Children s Hospital, 4060 Ste Catherine West, Room 200, Montreal, Canada H3Z 2Z3
    Atherosclerosis 167:205-14. 2003
  5. pmc Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1547-52. 2006
  6. pmc Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation
    Qiping Feng
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Genet Metab 102:126-33. 2011
  7. ncbi Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status
    E O Uthus
    U S Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr 132:1122-8. 2002
  8. pmc Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems
    Dmitry A Rodionov
    Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoi Karetny pereulok 19, Moscow 127994, Russia
    Nucleic Acids Res 32:3340-53. 2004
  9. doi Expression of methylation pathway enzymes in bovine oocytes and preimplantation embryos
    Shuntaro Ikeda
    Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    J Exp Zool A Ecol Genet Physiol 313:129-36. 2010
  10. pmc Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochem J 395:363-71. 2006

Research Grants

  1. Neil Kaplowitz; Fiscal Year: 2014
  2. NUTRIENT REGULATION OF BHMT EXPRESSION
    Timothy Garrow; Fiscal Year: 2006
  3. INTERACTION OF METHYLTRANSFERASE AND GLYCINE BORONATES
    Robert Lindquist; Fiscal Year: 1990
  4. NUTRIENT REGULATION OF BHMT EXPRESSION
    Timothy Garrow; Fiscal Year: 2003
  5. Quantitation of Tocopherol Metabolism in Humans
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
  6. Quantitation of In Vivo Human Lutein Metabolism
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
  7. DYNAMIC AND KINETIC BEHAVIOR OF FOLATE METABOLISM
    Andrew Clifford; Fiscal Year: 2005
  8. IN VIVO DYNAMIC OF BETA-CAROTENE METABOLISM IN HUMANS
    Andrew Clifford; Fiscal Year: 2006
  9. FASEB Summer Conference: Folate, B12 and 1C Metabolism
    JAMES FINKELSTEIN; Fiscal Year: 2002
  10. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010

Detail Information

Publications212 found, 100 shown here

  1. ncbi Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats
    Cindy D Davis
    US Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 133:2907-14. 2003
    ..05) colonic DNA methylation and the activities of liver DNA methyltransferase and betaine homocysteine methyltransferase and increased plasma glutathione concentrations. Folate deficiency increased (P < 0...
  2. ncbi Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD)
    Sandy Slow
    Biochemistry Unit, Canterbury Health Laboratories, P O Box 151, Christchurch, New Zealand
    Exp Toxicol Pathol 58:285-90. 2007
    ..Toxicity associated with DMT treatment raises concerns for its use in further studies. However, sub-acute administration of DMT to sheep may provide a useful model of acute alveolar damage...
  3. pmc Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically
    Joan Oliva
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St Torrance, CA 90502, USA
    World J Gastroenterol 15:705-12. 2009
    ..To examine the effects of ethanol-induced proteasome inhibition, and the effects of proteasome inhibition in the regulation of epigenetic mechanisms...
  4. ncbi Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease
    Ilan S Weisberg
    Department of Human Genetics, McGill University Health Center Montreal Children s Hospital, 4060 Ste Catherine West, Room 200, Montreal, Canada H3Z 2Z3
    Atherosclerosis 167:205-14. 2003
    ....
  5. pmc Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1547-52. 2006
    ..Most studies addressed these genes individually, often with different populations providing conflicting results...
  6. pmc Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation
    Qiping Feng
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Genet Metab 102:126-33. 2011
    ..These observations may help us to understand individual variation in the regulation of BHMT in the human liver and its possible relationship to variation in methylation...
  7. ncbi Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status
    E O Uthus
    U S Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr 132:1122-8. 2002
    ..02) by selenium deficiency. The activities of liver betaine homocysteine methyltransferase, methionine synthase, S-adenosylmethionine synthase, cystathionine synthase and cystathionase were ..
  8. pmc Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems
    Dmitry A Rodionov
    Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoi Karetny pereulok 19, Moscow 127994, Russia
    Nucleic Acids Res 32:3340-53. 2004
    ..In particular, Oceanobacillus iheyensis possibly uses a homolog of the betaine-homocysteine methyltransferase bhmT gene from vertebrates to substitute missing bacterial-type methionine synthases...
  9. doi Expression of methylation pathway enzymes in bovine oocytes and preimplantation embryos
    Shuntaro Ikeda
    Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    J Exp Zool A Ecol Genet Physiol 313:129-36. 2010
    ..These results provide a new insight into nutrient-sensitive epigenetic regulation and perturbation at the earliest stage of our life...
  10. pmc Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochem J 395:363-71. 2006
    ....
  11. ncbi Betaine can partially spare choline in chicks but only when added to diets containing a minimal level of choline
    Ryan N Dilger
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 137:2224-8. 2007
    ..However, addition of betaine to diets containing minimal choline allows a marked reduction in the total dietary choline requirement...
  12. doi Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes
    Andrea K Lawrance
    Departments of Human Genetics, Pediatrics, and Biology, McGill University Montreal Children s Hospital Research Institute, Montreal, H3Z 2Z3, Canada
    J Inherit Metab Dis 34:147-57. 2011
    ..In addition, our novel findings of decreased spleen weights, thrombocytopenia, and impaired retinal function warrant investigation in patients with severe MTHFR deficiency or other forms of homocystinuria...
  13. ncbi Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats
    Sandy Slow
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana IL 61801, USA
    J Nutr 136:2279-83. 2006
    ..Some degree of fatty liver developed in all rats fed a choline-devoid diet, indicating that supplemental Met cannot completely compensate for the lack of dietary choline in growing rats...
  14. ncbi Heat stress modulates hepatocyte membrane proteins during endotoxemia
    Rene Przkora
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA
    Burns 33:628-33. 2007
    ..This study investigates the influence of HS on hepatocyte membrane proteins during endotoxemia using 2D gel electrophoresis...
  15. pmc S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase
    Jiri Jiracek
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10 Prague 6, Czech Republic
    J Med Chem 49:3982-9. 2006
    ..Some of these compounds are currently being tested in mice to study the influence of BHMT on the metabolism of sulfur amino acids in vivo...
  16. ncbi Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes
    L H Chadwick
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Genomics 70:66-73. 2000
    ....
  17. ncbi Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations
    D O McGregor
    Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand
    Kidney Int 59:2267-72. 2001
    ..DMG is a known feedback inhibitor of BHMT. We postulated that DMG might accumulate in CRF and contribute to hyperhomocysteinemia by inhibiting BHMT activity...
  18. ncbi High casein diet decreases plasma homocysteine concentration in rats
    Seiya Ohuchi
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga ku, Shizuoka 422 8529, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:22-30. 2009
    ....
  19. pmc Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism
    Karin Engström
    Department of Laboratory Medicine, Section of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 119:182-8. 2011
    ..The fraction of urinary MMA is a marker for susceptibility to As-related diseases...
  20. ncbi Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic
    Michael Lever
    Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Biochem 40:1225-31. 2007
    ..To find whether the control of betaine metabolism differs between male and female patients and identify the effects of insulin and other hormones...
  21. doi Proteomic analysis on the alteration of protein expression in gills of ayu (Plecoglossus altivelis) associated with salinity change
    Xin J Lu
    Faculty of Life Science and Biotechnology, Ningbo University, Ningbo City 315211, People s Republic of China
    Comp Biochem Physiol Part D Genomics Proteomics 5:185-9. 2010
    ..It was suggested that cell volume-regulatory response, especially the protection by the BHMT/betaine system might play an important role in ayu acclimation to salinity change...
  22. pmc Yeast, plants, worms, and flies use a methyltransferase to metabolize age-damaged (R,S)-AdoMet, but what do mammals do?
    Chris R Vinci
    Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    Rejuvenation Res 13:362-4. 2010
    ..We find no evidence for the enzymatic breakdown of (R,S)-AdoMet in these extracts. Thus, mammals may metabolize (R,S)-AdoMet using a different strategy than other organisms...
  23. ncbi High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry
    Klaus Meyer
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Clin Chem 50:391-402. 2004
    ..Future large epidemiologic studies of the genetic basis of hyperhomocysteinemia will require high-throughput assays for polymorphisms of genes related to folate and Hcy metabolism...
  24. ncbi In vitro modification of betaine-homocysteine S-methyltransferase by tissue-type transglutaminase
    Akira Ichikawa
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Int J Biochem Cell Biol 36:1981-92. 2004
    ..This regulatory reaction might be involved in the regulation of homocysteine metabolism in the liver...
  25. ncbi Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 213:216-23. 2006
    ....
  26. ncbi Inborn errors of sulfur-containing amino acid metabolism
    James D Finkelstein
    Department of Veterans Affairs Medical Center and Department of Medicine, George Washington University, Washington DC 20422, USA
    J Nutr 136:1750S-1754S. 2006
    ..with isolated defects in all of the reactions of the combined pathway with only one exception: betaine homocysteine methyltransferase. Studies of these inborn errors have contributed significantly to our knowledge of human ..
  27. ncbi Proteomic analysis of membrane-associated proteins from rat liver autophagosomes
    Anders Øverbye
    Proteomics Section, Department of Cell Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet HF, University of Oslo, Oslo, Norway
    Autophagy 3:300-22. 2007
    ....
  28. ncbi Rat liver 10-formyltetrahydrofolate dehydrogenase, carbamoyl phosphate synthetase 1 and betaine homocysteine S-methytransferase were co-purified on Kunitz-type soybean trypsin inhibitor-coupled sepharose CL-4B
    Hyun Sic Kim
    College of Pharmacy, Pusan National University, Jangjeon Dong, Kumjeong Ku, Busan 609 735, Korea
    J Biochem Mol Biol 40:604-9. 2007
    ..These results demonstrate that the catalytic site of rat FDH has a similar structure with those of serine proteases. Also, the SBTI-affinity column will be useful for the purification of rat liver proteins such as FDH, CPS1 and BHMT...
  29. ncbi Homocysteine metabolism in diabetes
    E P Wijekoon
    Department of Biochemistry, Memorial University of Newfoundland, St John s, NL, Canada A1B 3X9
    Biochem Soc Trans 35:1175-9. 2007
    ....
  30. ncbi Novel interaction partners of Bardet-Biedl syndrome proteins
    F Oeffner
    Center of Human Genetics, University of Marburg, 35037 Marburg, Germany
    Cell Motil Cytoskeleton 65:143-55. 2008
    ..Our work provides new insights into the understanding of BBS interactions and thus their biological function...
  31. doi Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance
    John T Brosnan
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Canada A1B 3X9
    J Nutr 139:1292-7. 2009
    ..Creatine synthesis is a quantitatively major metabolic process in piglets...
  32. doi Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo
    W Y Kwong
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK
    Reproduction 139:705-15. 2010
    ..These data provide an insight into the importance of maternal dietary folate/B-vitamin status during the peri-conceptional period...
  33. pmc Regulation of homocysteine metabolism and methylation in human and mouse tissues
    Natalie C Chen
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad St, MRB, Philadelphia, PA 19140, USA
    FASEB J 24:2804-17. 2010
    ..Our study is the first to provide panoramic tissue gene expression profiles and mathematical models of tissue methylation regulation...
  34. doi A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP
    Sophia Harlid
    Department of Medical Microbiology, Lund University, Malmo, Sweden
    Int J Cancer 129:1689-98. 2011
    ..In conclusion, a candidate gene search strategy focusing on methylation-related SNPs did identify a SNP that associated with breast cancer at high significance...
  35. pmc Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes
    Radhika S Ganu
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, 1201 W Gregory Dr, Urbana, IL 61801, USA
    Gene 473:133-8. 2011
    b>Betaine homocysteine methyltransferase (BHMT) and BHMT-2 enzymes methylate homocysteine to form methionine using betaine and S-methylmethionine, respectively...
  36. doi BHMT G742A and MTHFD1 G1958A polymorphisms and Down syndrome risk in the Brazilian population
    Bruna Lancia Zampieri
    Department of Biología Molecular, Faculdade de Medicina de São José do Rio Preto FAMERP, Unidade de Pesquisa em Genética e Biologia Molecular UPGEM, Sao Jose do Rio Preto, SP, Brazil
    Genet Test Mol Biomarkers 16:628-31. 2012
    ..Mechanisms underlying meiotic nondisjunction are poorly understood. Attempts to elucidate the causes of Down syndrome (DS) have analyzed the relationship between polymorphism in folate metabolism and DS...
  37. pmc Maternal risk for Down syndrome is modulated by genes involved in folate metabolism
    Bruna Lancia Zampieri
    Unidade de Pesquisa em Genética e Biologia Molecular UPGEM, Sao Jose do Rio Preto, Sao Paulo, Brazil
    Dis Markers 32:73-81. 2012
    ..66A>G polymorphism affects the MMA concentration. These results are consistent with the modulation of the maternal risk for DS by these polymorphisms...
  38. pmc Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes
    Weijia Xie
    Genetics of Complex Traits, Peninsula School of Medicine, University of Exeter, Exeter, UK
    Diabetes 62:2141-50. 2013
    ..Genetic variants associated with genes in the glycine biosynthesis pathways do not provide consistent evidence for a role of glycine in diabetes-related traits...
  39. doi Osmotic regulation of hepatic betaine metabolism
    Lars Hoffmann
    Department of General Paediatrics, University Children s Hospital, Heinrich Heine University, Duesseldorf, Germany
    Am J Physiol Gastrointest Liver Physiol 304:G835-46. 2013
    ..changes in the expression of various genes involved in betaine metabolism, in particular of betaine homocysteine methyltransferase, dimethylglycine dehydrogenase, and sarcosine dehydrogenase...
  40. doi Alterations in the metabolomics of sulfur-containing substances in rat kidney by betaine
    Young Chul Kim
    College of Pharmacy, Seoul National University, San 56 1 Shinrim Dong, Kwanak Ku, Seoul, 151 742, Korea
    Amino Acids 46:963-8. 2014
    ..Further studies need to be conducted to clarify the physiological/pharmacological significance of these findings...
  41. pmc Genome-wide association study of selenium concentrations
    Marilyn C Cornelis
    Channing Division of Network Medicine, Department of Nutrition
    Hum Mol Genet 24:1469-77. 2015
    ..Our findings show evidence of a genetic link between Se and Hcy pathways, both involved in cardiometabolic disease. ..
  42. doi Assessment of the European flounder responses to chemical stress in the English Channel, considering biomarkers and life history traits
    Célie Dupuy
    Universite Europeenne de Bretagne, Universite de Bretagne Occidentale, UMR 6539 CNRS UBO IRD IFREMER, Laboratoire des Sciences de l Environnement Marin LEMAR, Institut Universitaire Europeen de la Mer, 29280 Plouzane, France Institut National de la Recherche Scientifique, Institut Armand Frappier INRS IAF, 31 Boulevard des Prairies, Laval, Quebec H7V 1B7, Canada Electronic address
    Mar Pollut Bull 95:634-45. 2015
    ..Flounder life history traits were analyzed by otolith microchemistry, in order to depict how the fish use their habitat and thus respond to chemical stress in estuaries. ..
  43. doi Role of defective methylation reactions in ethanol-induced dysregulation of intestinal barrier integrity
    Paul G Thomes
    Research Service, Veterans Affairs Nebraska Western Iowa Health Care System, Omaha, NE 68105, USA Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biochem Pharmacol 96:30-8. 2015
    ..We also propose betaine as a potential therapeutic option for leaky gut in alcohol-consuming patients who are at the risk of developing ALD. ..
  44. pmc Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes
    Radhika S Ganu
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, United States of America
    PLoS ONE 10:e0134084. 2015
    ..The dN/dS ratios in both BHMT and BHMT2 was highest following the gene duplication, suggesting that purifying selection played a lesser role as the two paralogs diverged in function. ..
  45. pmc Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice
    Sapna Gupta
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA
    J Inherit Metab Dis 39:39-46. 2016
    ..Our findings indicate that while betaine supplementation does have some beneficial effects, it is not as effective as methionine restriction for reversing the phenotypes associated with severe CBS deficiency in mice. ..
  46. pmc NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice
    Thomas V A Murray
    Cardiovascular Division, King s College London, 125 Coldharbour Lane, London E5 0AD
    Free Radic Biol Med 89:918-30. 2015
    ....
  47. pmc Comparative transcriptome analysis on the alteration of gene expression in ayu (Plecoglossus altivelis) larvae associated with salinity change
    Xin jiang Lu
    Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo 315211, China
    Dongwuxue Yanjiu 37:126-35. 2016
    ..Our data indicate that FW acclimation reduced the growth rate of ayu larvae, which might result from the expression alteration of genes related to endocrine hormones, energy metabolism, and direct osmoregulation. ..
  48. doi Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China
    Yu feng Du
    1Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    Br J Nutr 116:961-8. 2016
    ..Our results suggest that SNP PEMT rs7946 and BHMT rs3733890 may interact with choline intake on breast cancer risk. ..
  49. ncbi Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients
    Shizhen Qin
    Institute for Systems Biology, 401 Terry North, Seattle, Washington 98109 5234, United States
    J Proteome Res 15:3724-3740. 2016
    ..85, specificity: 0.84, accuracy: 85%). These five blood proteins are candidates for detecting acetaminophen-induced liver injury using next-generation diagnostic devices (e.g, microfluidic ELISA assays)...
  50. pmc Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations
    Ariel B Ganz
    Cornell University, Division of Nutritional Sciences, Ithaca, NY 14853, USA
    Int J Mol Sci 18:. 2017
    ..Such metabolic differences may contribute to disease pathogenesis and prognosis over the long-term...
  51. ncbi Methionine supply to growing steers affects hepatic activities of methionine synthase and betaine-homocysteine methyltransferase, but not cystathionine synthase
    Barry D Lambert
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 1600, USA
    J Nutr 132:2004-9. 2002
    ..04), with 0 and 10 g/d Met being higher than the intermediate level. Data from this experiment indicate that sulfur amino acid metabolism may be regulated differently in cattle than in other tested species...
  52. ncbi Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase
    Michaela Collinsova
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 16610 Praha 6, Czech Republic
    Chem Biol 10:113-22. 2003
    ..Further optimization uncovered Val-Phe-psi[PO(2-)-CH(2)]-Leu-His-NH(2) as a potent BHMT inhibitor that has an IC(50) of about 1 microM...
  53. ncbi Betaine analogues alter homocysteine metabolism in rats
    Sandy Slow
    Biochemistry Unit, Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand
    Int J Biochem Cell Biol 36:870-80. 2004
    ..The study shows that glycine betaine analogues have multiple effects on homocysteine metabolism (250)...
  54. ncbi Betaine: a key modulator of one-carbon metabolism and homocysteine status
    Per Magne Ueland
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, Bergen, Norway
    Clin Chem Lab Med 43:1069-75. 2005
    ..Betaine status should be investigated in pathologies related to altered metabolism of homocysteine and folate, including cardiovascular disease, cancer and neural tube defects...
  55. pmc Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, ND 58202 9034, USA
    Mech Ageing Dev 127:444-50. 2006
    ..3-fold, p = 0.013), glycine N-methyltransferase (3.8-fold, p = 0.023), betaine homocysteine methyltransferase (5.5-fold, p = 0.0006), S-adenosylhomocysteine hydrolase (3.8-fold, p = 0...
  56. ncbi Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice
    Michaela Collinsova
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 136:1493-7. 2006
    ..These studies are the first to show that transient inhibition of BHMT in vivo causes transient hyperhomocysteinemia, and that dimethylsulfoniopropionate can reduce a post-Met load rise in tHcy...
  57. doi The GST-BHMT assay and related assays for autophagy
    Patrick B Dennis
    University of Cincinnati, Genome Research Institute, Department of Cancer and Cell Biology, Cincinnati, Ohio, USA
    Methods Enzymol 452:97-118. 2009
    ..b>Betaine homocysteine methyltransferase (BHMT) is one of many cytosolic proteins found in the mammalian autophagosome, and delivery of ..
  58. pmc 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Med Genet 10:49. 2009
    ..Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved in folate transport and metabolism...
  59. pmc Gene expression modifications in the liver caused by binge drinking and S-adenosylmethionine feeding. The role of epigenetic changes
    Jun Li
    LABioMed Research Institute at Harbor UCLA Medical Center, 1000 W Carson St, Los Angeles, CA, 90509, USA
    Genes Nutr 5:169-79. 2010
    ..In conclusion, profound changes in gene expression evolved between 3 h and 12 post ethanol bolus. SAMe down regulated these changes in gene expression at 3 h, and less so at 12 h...
  60. doi All-trans-retinoic acid intensifies endoplasmic reticulum stress in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells by perturbing homocysteine metabolism
    Ying Ying Xu
    Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, 130 Dongan Road, Shanghai 200032, China
    J Cell Biochem 109:468-77. 2010
    ..These results provide support for the hypothesis that ATRA is an anticancer agent...
  61. pmc Maternal folate-related gene environment interactions and congenital heart defects
    Charlotte A Hobbs
    Department of Pediatrics, Birth Defects Research Section, Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, Arkansas, USA
    Obstet Gynecol 116:316-22. 2010
    ..To investigate whether women with congenital heart defect (CHD)-affected pregnancies were more likely to have functional single-nucleotide polymorphisms in genes encoding enzymes in folate-dependent pathways...
  62. doi Folate and choline metabolism gene variants and development of uterine cervical carcinoma
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
    Clin Biochem 44:596-600. 2011
    ..The aim of this study was to evaluate the possibility that polymorphic variants of genes that may affect DNA methylation status are associated with the risk of cervical cancer in the Polish population...
  63. doi Homocysteine homeostasis in the rat is maintained by compensatory changes in cystathionine β-synthase, betaine-homocysteine methyltransferase, and phosphatidylethanolamine N-methyltransferase gene transcription occurring in response to maternal protein an
    Agata Chmurzynska
    Department of Human Nutrition and Hygiene, Poznań University of Life Sciences Wojska Polskiego 31, 60 624 Poznan
    Nutr Res 31:572-8. 2011
    ..We conclude that maternal diet during gestation has an important effect on the transcription level of these 3 genes, but changes in gene expression were not associated with significant changes in progeny homocysteine concentrations...
  64. pmc Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
    Ya Wen Teng
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:36258-67. 2011
    ..A lack of Bhmt also affects susceptibility to fatty liver and hepatocellular carcinoma. We suggest that functional polymorphisms in BHMT that significantly reduce activity may have similar effects in humans...
  65. doi Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk
    Ana Lívia Silva Galbiatti
    Genetics and Molecular Biology Research Unit, UPGEM, University Graduate School of Medical, Sao Jose do Rio Preto, Brazil
    Eur J Cancer 48:1525-31. 2012
    ....
  66. doi Intrauterine growth restriction leads to changes in sulfur amino acid metabolism, but not global DNA methylation, in Yucatan miniature piglets
    Dylan S Mackay
    Department of Biochemistry, Memorial University of Newfoundland, St John s, NL, Canada
    J Nutr Biochem 23:1121-7. 2012
    ....
  67. ncbi Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women
    Julie M W Wallace
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, County Londonderry, UK
    Br J Nutr 108:1264-71. 2012
    ....
  68. pmc Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males
    Susan M Wernimont
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    J Nutr 142:1272-9. 2012
    ..This work supports a role for SHMT1-related genes and nuclear folate metabolism, including the thymidylate biosynthesis pathway, in mediating CVD risk...
  69. doi Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome
    J M Biselli
    Departamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto FAMERP, Unidade de Pesquisa em Genética e Biologia Molecular UPGEM, Av Brigadeiro Faria Lima, n o 5416 Bloco U 6, Sao Jose do Rio Preto, SP, CEP 15 090 000, Brazil
    Mol Biol Rep 39:9277-84. 2012
    ..These findings could help to understand how genetic variation impacts folate metabolism and what metabolic consequences these variants have in individuals with trisomy 21...
  70. pmc Proteomic differences between hepatocellular carcinoma and nontumorous liver tissue investigated by a combined gel-based and label-free quantitative proteomics study
    Dominik A Megger
    Medizinisches Proteom Center, Ruhr Universitat Bochum, Bochum, Germany
    Mol Cell Proteomics 12:2006-20. 2013
    ..Based on these results we assume that major vault protein and betaine-homocysteine S-methyltransferase have the potential to act as diagnostic HCC biomarker candidates that are worth to be followed in further validation studies. ..
  71. doi Characterization of differentially expressed genes in liver in response to the rearing temperature of rainbow trout Oncorhynchus mykiss and their heritable differences
    Hiromi Oku
    National Research Institute of Aquaculture, Tamaki Station, Tamaki, Mie, 519 0423, Japan
    Fish Physiol Biochem 40:1757-69. 2014
    ..On the other hand, three metabolic genes (betaine homocysteine methyltransferase, triosephosphate isomerase, and glucose-6-phosphatase) were down-regulated, indicating a metabolic ..
  72. doi Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice
    Raquel Martínez-Vega
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029, Madrid, Spain, Unidad 761, Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Instituto de Salud Carlos III, 28029, Madrid, Spain
    J Nutr Biochem 26:1424-33. 2015
    ..Altogether, the results obtained suggest a long-term protective role of omega-3 supplementation on cochlear metabolism and progression of hearing loss. ..
  73. pmc Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo
    Halina Jurkowska
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA
    Amino Acids 48:665-76. 2016
    ..Within the liver, mRNA abundance for both CSAD and BHMT was upregulated in parallel with protein levels, indicating regulation of BHMT and CSAD mRNA synthesis or degradation...
  74. doi Metabolic dysregulation in first-episode schizophrenia patients with respect to genetic variation in one-carbon metabolism
    Błazej Misiak
    Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50 367 Wroclaw, Poland Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50 368 Wroclaw, Poland Electronic address
    Psychiatry Res 238:60-7. 2016
    ..None of them remained significant after Bonferroni correction. Our results indicate that metabolic dysregulation in patients with FES is not associated with genetic variation in one-carbon metabolism...
  75. doi Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway
    Yang Yang
    Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China
    Int J Biochem Cell Biol 79:222-230. 2016
    ....
  76. pmc The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers
    Sara Moruzzi
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    PLoS ONE 11:e0167534. 2016
    ....
  77. ncbi Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation
    Abdulrahman A Idriss
    Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P R China
    Poult Sci . 2016
    ..These results indicate that maternal betaine modulates hypothalamic cholesterol metabolism in cockerels through modifying DNA methylation on the promoter of cholesterol metabolic genes...
  78. ncbi Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro
    Melanie C Fisher
    Department of Cell Biology and Anatomy, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7090, USA
    FASEB J 16:619-21. 2002
    ..Choline was oxidized to betaine, and betaine homocysteine methyltransferase was expressed...
  79. ncbi Betaine homocysteine methyltransferase: gene cloning and expression analysis in rat liver cirrhosis
    Marc Forestier
    Department of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH 3010, Berne, Switzerland
    Biochim Biophys Acta 1638:29-34. 2003
    ..Using differential display, we identified betaine homocysteine methyltransferase (BHMT) as a gene down-regulated in rat liver cirrhosis and most likely involved in this ..
  80. ncbi Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol
    Ephraim Sehayek
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Lipid Res 44:1605-13. 2003
    ..A prominent protein revealed by this analysis was betaine homocysteine methyltransferase (BHMT)...
  81. ncbi Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation
    Pal I Holm
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, N 5021 Bergen, Norway
    Arterioscler Thromb Vasc Biol 24:301-7. 2004
    ..Betaine is a substrate in the betaine-homocysteine methyltransferase reaction, converting homocysteine to methionine. There are only sparse data on plasma betaine as a determinant of the plasma total homocysteine (tHcy) concentration...
  82. ncbi Crystal structure of rat liver betaine homocysteine s-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding
    Beatriz Gonzalez
    Grupo de Cristalografia Macromolecular y Biologia Estructural, Instituto de Quimica Fisica Rocasolano, CSIC, Serrano 119, 28006 Madrid, Spain
    J Mol Biol 338:771-82. 2004
    ..Two residues essential for substrate recognition, Phe76 and Tyr77, are provided by a conformational change in a partially disordered loop (L2). The crucial role of these residues is highlighted by site-directed mutagenesis...
  83. ncbi Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency
    Bernd C Schwahn
    Department of Pediatrics, Montreal Children s Hospital, McGill University Health Center, Montrreal, Quebec, Canada
    Metabolism 53:594-9. 2004
    ..Homocysteinemia in mice is sensitive to a disruption of Cbs and to methyl donor intake. Because betaine leads to a greater flux through BHMT and lowers homocysteine, betaine supplementation may be beneficial in mild hyperhomocysteinemia...
  84. ncbi A nuclear-magnetic-resonance-based assay for betaine-homocysteine methyltransferase activity
    Martin B Lee
    Biochemistry Unit, Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand
    Anal Biochem 330:199-205. 2004
    ..19+/-0.03 mM with a V(max) of 17+/-0.7 nMol min(-1) mg(-1)...
  85. ncbi Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
    William Steele
    Division of Obstetrics and Gynaecology, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Reprod Biomed Online 10:755-66. 2005
    ..These studies indicate that altered methyl group metabolism provides a potential mechanism for inducing epigenetic changes in the preimplantation embryo...
  86. ncbi Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver
    Shobhitha Ratnam
    Dept of Biochemistry, Memorial University of Newfoundland, St John s, NF, Canada, A1B 3X9
    Am J Physiol Endocrinol Metab 290:E933-9. 2006
    ....
  87. ncbi Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats
    Kristin M Nieman
    Dept of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Am J Physiol Endocrinol Metab 291:E1235-42. 2006
    ..Moreover, the upregulation of BHMT and PEMT may indicate an increased choline requirement in the diabetic rat...
  88. pmc Interrelations between glycine betaine catabolism and methionine biosynthesis in Sinorhizobium meliloti strain 102F34
    Lise Barra
    Osmorégulation chez les bactéries, UMR CNRS 6026, Universite de Rennes I, Campus de Beaulieu, Av du Général Leclerc, 35042 Rennes, France
    J Bacteriol 188:7195-204. 2006
    ..Inactivation of metH or bmt did not affect the nodulation efficiency of the mutants in the 102F34 strain background. Nevertheless, a metH strain was severely defective in competing with the wild-type strain in a coinoculation experiment...
  89. ncbi Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
    M A Pajares
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029, Madrid, Spain
    Cell Mol Life Sci 63:2792-803. 2006
    b>Betaine homocysteine methyltransferase (BHMT), a Zn(2+)-dependent thiolmethyltransferase, contributes to the regulation of homocysteine levels, increases in which are considered a risk factor for cardiovascular diseases...
  90. ncbi Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C->t genotypes and B-vitamin status in a large-scale epidemiological study
    Pal I Holm
    Hormone Laboratory, Haukeland University Hospital, Section for Pharmacology, Institute of Medicine, Armauer Hanssens hus, University of Bergen, 5021 Bergen, Norway
    J Clin Endocrinol Metab 92:1535-41. 2007
    ....
  91. pmc Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase
    Václav Vanek
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v v i, Flemingovo nam 2, 166 10 Prague 6, Czech Republic
    J Med Chem 52:3652-65. 2009
    ....
  92. pmc An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity
    Hong Hsing Liu
    Department of Genetics and Genomics, Roche Palo Alto, Palo Alto, California 94304, USA
    Genome Res 20:28-35. 2010
    ..Identification of Bhmt2 and the affected biosynthetic pathway demonstrates how a novel method of integrative genomic analysis in mice can provide a unique and clinically applicable approach to a major public health problem...
  93. pmc The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia
    Patricia M DiBello
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 9:471-85. 2010
    ..Our results show that hyperhomocysteinemia, whether caused by a genetic mutation or diet, alters the abundance of several liver proteins involved in homocysteine/methionine metabolism, the urea cycle, and antioxidant defense...
  94. pmc Variants of folate metabolism genes and the risk of conotruncal cardiac defects
    Elizabeth Goldmuntz
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Circ Cardiovasc Genet 1:126-32. 2008
    ..However, efforts to establish the relationships between these factors and CHD risk have been hampered by a number of factors including small study sample sizes and phenotypic heterogeneity...
  95. pmc Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats
    Masao Shinohara
    University of Southern California Research Center for Liver Disease, USC University of California Los Angeles Research Center for Alcoholic Liver and Pancreas Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Hepatology 51:796-805. 2010
    ..Western blot analysis of betaine homocysteine methyltransferase (BHMT) expression showed that rats fed either ethanol or HMLF had significantly increased BHMT ..
  96. doi Choline and betaine in health and disease
    Per Magne Ueland
    Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway
    J Inherit Metab Dis 34:3-15. 2011
    ..Thus, choline and betaine showed opposite relations with key components of metabolic syndrome, suggesting a disruption of mitochondrial choline oxidation to betaine as part of the mitochondrial dysfunction in metabolic syndrome...
  97. doi Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland
    Eur J Oral Sci 118:325-32. 2010
    ..Altogether, our study identified a novel gene, the nucleotide variants of which were be associated with a decreased risk of having a baby with NCL/P...
  98. doi Genetic variants in one-carbon metabolism-related genes contribute to NSCLC prognosis in a Chinese population
    Guangfu Jin
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China
    Cancer 116:5700-9. 2010
    ..In this study, the authors hypothesized that polymorphisms in one-carbon metabolism-related genes may contribute to the prognosis of nonsmall cell lung cancer (NSCLC)...
  99. pmc CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 25:253-68. 2011
    ..Thus, C/EBPα/β mediate the terminal differentiation of GCs during the complex process of luteinization...
  100. doi Sulfur amino acid metabolism in doxorubicin-resistant breast cancer cells
    Chang Seon Ryu
    College of Pharmacy and RCTCP, Chungnam National University, Daejeon 305 764, Republic of Korea
    Toxicol Appl Pharmacol 255:94-102. 2011
    ..such as cystathionine beta-synthase, methionine synthase/methylene tetrahydrofolate reductase, and betaine homocysteine methyltransferase, was up-regulated in MCF-7/Adr cells, suggesting that acquiring doxorubicin resistance attenuated ..
  101. doi Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet
    Kang Uk Yun
    College of Pharmacy, Chungnam National University, 220 Gung Dong, Yuseong Gu, Taejeon, 305 764, Republic of Korea
    Eur J Nutr 52:127-34. 2013
    ..However, little published information is available concerning the effect of obesity on homocysteine metabolism...

Research Grants19

  1. Neil Kaplowitz; Fiscal Year: 2014
    ..Therefore, understanding how alcohol increase homocysteine levels and how increased levels of homocysteine contribute to liver damage will open new avenues for preventing and treating liver disease due to alcohol and other causes. ..
  2. NUTRIENT REGULATION OF BHMT EXPRESSION
    Timothy Garrow; Fiscal Year: 2006
    ..The outcomes of the proposed studies will include novel information on IBHMT's structure and function and its regulation by nutritional and physiological factors influencing Iredox status. ..
  3. INTERACTION OF METHYLTRANSFERASE AND GLYCINE BORONATES
    Robert Lindquist; Fiscal Year: 1990
    ..B), H2NCH(CH3)-B(OH)2, has very recently been reported. It is an effective inhibitor of both alanine- racemase and D-Ala:D-Ala ligase, presumably interacting with one or more groups at the active sites of these enzymes...
  4. NUTRIENT REGULATION OF BHMT EXPRESSION
    Timothy Garrow; Fiscal Year: 2003
    ....
  5. Quantitation of Tocopherol Metabolism in Humans
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..Particular attention will be directed to the absorption phase. The results are expected to provide information about vitamin E biopotency and eventually improved Dietary Recommendations. ..
  6. Quantitation of In Vivo Human Lutein Metabolism
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..Therefore, the purpose of this study is to determine how the human body uses lutein and other related compounds. ..
  7. DYNAMIC AND KINETIC BEHAVIOR OF FOLATE METABOLISM
    Andrew Clifford; Fiscal Year: 2005
    ..We will determine the in vivo kinetic behavior of a tracer dose of folate in blood, urine, and stool. We will then compare the behavior of folate metabolism (functional endpoint) among the various genotypes. ..
  8. IN VIVO DYNAMIC OF BETA-CAROTENE METABOLISM IN HUMANS
    Andrew Clifford; Fiscal Year: 2006
    ....
  9. FASEB Summer Conference: Folate, B12 and 1C Metabolism
    JAMES FINKELSTEIN; Fiscal Year: 2002
    ..The format encourages discussions between the presenters and the fellows, residents and junior investigators in attendance. Similarly, the poster sessions also highlight the activities and the needs of the younger participants. ..
  10. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....
  11. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. [unreadable] [unreadable]..
  12. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004
    ..A potential link of two pathways whose products or intermediates are associated with increased cardiovascular disease risk could be established. ..
  13. Transition-state mimicking inhibitors of human BHMT
    Timothy Garrow; Fiscal Year: 2008
    ..Jiri Jiracek as an extension of NIH grant # R01DK52501. ..
  14. Gene-nutrient Etiologies of Neural Tube Defects
    Gary M Shaw; Fiscal Year: 2010
    ..Because NTDs result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  15. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. [unreadable] [unreadable]..
  16. Gene and Nutrient Etiologies of Human Heart Defects
    Gary M Shaw; Fiscal Year: 2010
    ..Because these defects result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  17. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  18. FOLATE PATHWAY GENES AND RISK FOR OROFACIAL CLEFTS
    Gary Shaw; Fiscal Year: 2002
    ..abstract_text> ..