C/EBPbeta

Summary

Gene Symbol: C/EBPbeta
Description: CCAAT/enhancer binding protein beta
Alias: C/EBP-beta, IL6DBP, NF-IL6, TCF5, CCAAT/enhancer-binding protein beta, CCAAT/enhancer binding protein (C/EBP), beta, interleukin 6-dependent DNA-binding protein, nuclear factor NF-IL6, nuclear factor of interleukin 6, transcription factor 5, transcription factor C/EBP beta
Species: human

Top Publications

  1. ncbi Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6
    Yue Xie
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:11802-10. 2002
  2. ncbi Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells
    Mark Christian
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Biol Chem 277:20825-32. 2002
  3. ncbi Cooperativity between Rad51 and C/EBP family transcription factors modulates basal and Tat-induced activation of the HIV-1 LTR in astrocytes
    Galina Chipitsyna
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 207:605-13. 2006
  4. pmc Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1
    Kenta Iijima
    Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Retrovirology 10:83. 2013
  5. doi CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells
    David A Armstrong
    Research Service, Department of Veterans Affairs, White River Junction, VT 05009, USA
    Mol Cancer Res 7:1517-24. 2009
  6. ncbi Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta
    Irit Meivar-Levy
    The Endocrine Institute, Sheba Medical Center, Tel Hashomer, Israel
    Hepatology 46:898-905. 2007
  7. ncbi NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages
    Chaitali Basak
    Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Kolkata 700009, India
    J Biol Chem 280:4279-88. 2005
  8. pmc Translational control of C/EBPalpha and C/EBPbeta isoform expression
    C F Calkhoven
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Genes Dev 14:1920-32. 2000
  9. ncbi Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line
    M Matsumoto
    Department of Biochemistry, Hyogo College of Medicine, Japan
    Int Immunol 10:1825-35. 1998
  10. ncbi Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta
    T H Tahirov
    Kanagawa Academy of Science and Technology KAST, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama 236 0004, Kanazawa Ku, Japan
    Cell 104:755-67. 2001

Research Grants

  1. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
  2. DHAN V KALVAKOLANU; Fiscal Year: 2014
  3. Kezhong Zhang; Fiscal Year: 2016
  4. IL-17-Induced Regulation of C/EBPbeta
    MICHELLE ROSAN SIMPSON-ABELSON; Fiscal Year: 2012
  5. Gene Expression in Long-term Memory
    Cristina M Alberini; Fiscal Year: 2011
  6. C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVAL
    Mario Chojkier; Fiscal Year: 2012
  7. Huizhi Wang; Fiscal Year: 2014
  8. C/EBP BETA TRANSLATION PRODUCTS IN MAMMARY EPITHELIUM
    Julie Hutt; Fiscal Year: 2002
  9. Liver Lung Interactions in Lung Inflammation
    Brian Christman; Fiscal Year: 2006
  10. LIVER-LUNG INTERACTIONS FOLLOWING LIVER INJURY
    LEONARD WUDEL; Fiscal Year: 2002

Detail Information

Publications270 found, 100 shown here

  1. ncbi Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6
    Yue Xie
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:11802-10. 2002
    ..transcription of the IL-1beta promoter through direct interaction with the nuclear factor of interleukin 6 (NF-IL6, also known as CCAAT enhancer binding protein (C/EBPbeta), an essential regulator in IL-1beta ..
  2. ncbi Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells
    Mark Christian
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Biol Chem 277:20825-32. 2002
    ..These results provide the first evidence of regulated expression of FKHR and demonstrate that FKHR has an integral role in PKA-dependent endometrial differentiation through its ability to bind and functionally cooperate with C/EBPbeta...
  3. ncbi Cooperativity between Rad51 and C/EBP family transcription factors modulates basal and Tat-induced activation of the HIV-1 LTR in astrocytes
    Galina Chipitsyna
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 207:605-13. 2006
    ..These observations unravel a new pathway for Tat activation of the LTR that includes the positive feedback loop involving Rad51 and C/EBPbeta family proteins...
  4. pmc Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1
    Kenta Iijima
    Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Retrovirology 10:83. 2013
    ..Based on our data, we discuss the involvement of blood Vpr in the clinical symptoms of acquired immunodeficiency syndrome (AIDS)...
  5. doi CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells
    David A Armstrong
    Research Service, Department of Veterans Affairs, White River Junction, VT 05009, USA
    Mol Cancer Res 7:1517-24. 2009
    ..These studies establish CEBPB as an important mediator of metalloproteinase gene activation during inflammatory responses in lung cancer cells and highlight the different regulatory roles of CEBPB isoforms...
  6. ncbi Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta
    Irit Meivar-Levy
    The Endocrine Institute, Sheba Medical Center, Tel Hashomer, Israel
    Hepatology 46:898-905. 2007
    ..Hepatic dedifferentiation is necessary though not sufficient for the activation of the mature pancreatic repertoire in liver...
  7. ncbi NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages
    Chaitali Basak
    Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Kolkata 700009, India
    J Biol Chem 280:4279-88. 2005
    ..pylori LPS and are particularly important in the light of the observations that IL-1beta gene polymorphisms are associated with increased risk of H. pylori-associated gastric cancer...
  8. pmc Translational control of C/EBPalpha and C/EBPbeta isoform expression
    C F Calkhoven
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Genes Dev 14:1920-32. 2000
    ..Our results demonstrate that the translational controlled ratio of C/EBPalpha and C/EBPbeta isoform expression determines cell fate...
  9. ncbi Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line
    M Matsumoto
    Department of Biochemistry, Hyogo College of Medicine, Japan
    Int Immunol 10:1825-35. 1998
    ..These findings indicate that MIP-1 alpha is a direct target of NF-IL6...
  10. ncbi Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta
    T H Tahirov
    Kanagawa Academy of Science and Technology KAST, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama 236 0004, Kanazawa Ku, Japan
    Cell 104:755-67. 2001
    ..The point mutations of CBFalpha related to the aforementioned diseases were also mapped and their effect on DNA binding is discussed...
  11. ncbi CCAAT-enhancer-binding protein beta (C/EBP beta) activates CCR5 promoter: increased C/EBP beta and CCR5 in T lymphocytes from HIV-1-infected individuals
    M Rosati
    Human Retrovirus Section, Basic Research Laboratory, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 167:1654-62. 2001
    ..Taken together, these results suggest that C/EBPbeta is an important regulator of CCR5 expression and may play a relevant role in the pathogenesis of HIV disease...
  12. ncbi Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein
    Jian Du
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 277:43481-94. 2002
    ..Our findings identify novel combinatorial protein-protein interactions for GATA-1, PU.1, and C/EBPepsilon isoforms in eosinophil gene transcription that include GATA-1/PU.1 synergy and repressor activity for C/EBPepsilon(27)...
  13. pmc CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1β
    Zhiqi Zhang
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 285:33092-103. 2010
    ..Time course experiments indicated that C/EBPβ gradually and steadily induces chemokine up-regulation, whereas NF-κB activity was highest at the early stage of chemokine up-regulation...
  14. doi Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ
    Jewell N Walters
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA
    Biochem J 443:561-71. 2012
    ....
  15. pmc C/EBPβ regulates multiple IL-1β-induced human astrocyte inflammatory genes
    Jerel Fields
    University of North Texas Health Science Center, Camp Bowie Blvd, 3500, Fort Worth, TX, USA
    J Neuroinflammation 9:177. 2012
    ..C/EBPβ is detectable in brains of Alzheimer's disease (AD), Parkinson's disease (PD) and HIV-1-associated dementia (HAD) patients, yet little is known about how C/EBPβ contributes to astrocyte gene regulation during neuroinflammation...
  16. pmc Extracellular signal-regulated kinase 1/2 signaling pathway is required for endometrial decidualization in mice and human
    Chae Hyun Lee
    Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, Michigan, United States of America Department of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
    PLoS ONE 8:e75282. 2013
    ..These results suggest that ERK1/2 signaling is required for successful decidualization in mice as well as human endometrial stromal cells and implicates C/EBPβ as a downstream target of ERK1/2. ..
  17. pmc Pro-inflammatory cytokine induction of 11β-hydroxysteroid dehydrogenase type 1 in A549 cells requires phosphorylation of C/EBPβ at Thr235
    Cristina L Esteves
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e75874. 2013
    ....
  18. pmc 3'UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells
    Sandip K Basu
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, NIH, MD, USA
    EMBO J 30:3714-28. 2011
    ..Our findings reveal a novel mechanism whereby non-coding mRNA sequences selectively regulate C/EBPβ activity and suppress its anti-oncogenic functions...
  19. ncbi Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)
    S Nagulapalli
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 155:4330-8. 1995
    ..These results suggest that transcriptional synergy is due to each protein independently influencing the basal transcription complex...
  20. pmc CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling
    Songyun Zhu
    Cell Signaling and Cancer Group, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
    Proc Natl Acad Sci U S A 99:207-12. 2002
    ..These findings indicate that C/EBPbeta has a critical role in Ras-mediated tumorigenesis and cell survival and implicate C/EBPbeta as a target for tumor inhibition...
  21. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
    ..Our data indicate that IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation and suggest that IL-17 may play a critical role in myocardial remodeling...
  22. pmc Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression
    P Roux
    Laboratory of Molecular Virology, Ste Justine Hospital Research Center, Canada
    J Virol 74:4658-65. 2000
    ..These results suggest a new role for Vpr in the pathogenesis of HIV infection, namely, the activation of transcription factors NF-IL-6 and NF-kappaB...
  23. pmc CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection
    Iwao Komuro
    Department of Immunology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    J Exp Med 198:443-53. 2003
    ....
  24. pmc Induction of sodium iodide symporter gene and molecular characterisation of HNF3 beta/FoxA2, TTF-1 and C/EBP beta in thyroid carcinoma cells
    T Akagi
    Division of Hematology and Oncology, Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Br J Cancer 99:781-8. 2008
    ..In summary, these findings reveal novel abnormalities in thyroid carcinoma cells...
  25. doi HER2 silences tumor suppression in breast cancer cells by switching expression of C/EBPß isoforms
    Anna Arnal-Estapé
    Oncology Programme, Institute for Research in Biomedicine, Barcelona, Spain
    Cancer Res 70:9927-36. 2010
    ..Our findings reveal a novel mechanism through which HER2 silences tumor suppression in a concerted manner, contributing to the potency of this oncogene in breast cancer...
  26. pmc Identification and characterization of CCAAT enhancer-binding protein (C/EBP) as a transcriptional activator for Epstein-Barr virus oncogene latent membrane protein 1
    Chieko Noda
    Division of Virology, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Biol Chem 286:42524-33. 2011
    ..In conclusion, C/EBP is a newly identified transcriptional activator of the LMP1 gene, independent of the EBNA2 coactivator...
  27. ncbi A novel role of sodium butyrate in the regulation of cancer-associated aromatase promoters I.3 and II by disrupting a transcriptional complex in breast adipose fibroblasts
    Santanu Deb
    Division of Reproductive Biology Research, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:2585-97. 2006
    ..Together, these findings represent a novel mechanism of sodium butyrate action and provide evidence that aromatase activity can be ablated in a signaling pathway- and cell-specific fashion...
  28. ncbi Peroxisome proliferator-activated receptor-delta upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-beta
    Luca Brunelli
    Department of Pediatrics, The University of Texas at Houston Medical School, Houston, TX 77030 1503, USA
    Circ Res 100:e59-71. 2007
    ....
  29. pmc STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta
    Min Xu
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    EMBO J 22:893-904. 2003
    ..Thus, we propose a novel mechanism by which STAT5 mediates the deacetylation of C/EBPbeta, allowing transcriptional activation...
  30. pmc Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
    P L Chen
    Center for Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio 78245, USA
    Proc Natl Acad Sci U S A 93:465-9. 1996
    ..Such disparate mechanisms may help to explain the dual role of RB in cell differentiation and the cell division cycle...
  31. ncbi SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1
    S Rao
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 274:11115-24. 1999
    ..1 and harbors different transactivation domains. We conclude that SPI-B may activate unique target genes in B lymphocytes and interact with unique, although currently unidentified, cofactors...
  32. ncbi Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation
    Robert Kleemann
    Gaubius Laboratory Nederlandse Organisatie voor toegepast natuurwetenschappelijk onderzoek TNO Prevention and Health, Leiden, The Netherlands
    Blood 101:545-51. 2003
    ..Our findings identify C/EBP-beta and p50-NFkappaB as novel targets for PPAR-alpha and provide a molecular explanation for the reduction of plasma CRP levels by fibrates...
  33. pmc The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta
    Vladimir Hurgin
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:16957-62. 2002
    ..The IRF-1-CEBPbeta complex described here probably plays a fundamental role in regulating additional IFN-gamma-responsive genes...
  34. ncbi Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB
    Yong M Zhu
    Division of Respiratory Medicine, School of Medical and Surgical Sciences, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 278:29366-75. 2003
    ..Endogenous prostanoid generation in response to GPCR ligands such as BK may be an important mechanism whereby GPCRs signal to the nucleus to maximize the transcription of inflammatory response genes...
  35. ncbi Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages
    Yi Wen Liu
    Graduate Institute of Biopharmaceutics, College of Life Science, National Chiayi University, Chiayi, Taiwan
    J Immunol 171:821-8. 2003
    ..The increase of C/EBPbeta and delta proteins and the enhancement of transactivation activity of C/EBPbeta and delta by LPS treatment, at least in part, explain the activation of IL-10 gene expression...
  36. ncbi Interleukin-1 beta induction of matrix metalloproteinase-1 transcription in chondrocytes requires ERK-dependent activation of CCAAT enhancer-binding protein-beta
    Lauren Raymond
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Cell Physiol 207:683-8. 2006
    ..Our findings demonstrate a novel role for C/EBP-beta in IL-1beta-induced connective tissue disease and define a new nuclear target for the ERK pathway in MMP-1 gene activation...
  37. ncbi C/EBPbeta regulates human immunodeficiency virus 1 gene expression through its association with cdk9
    Giuseppe Mameli
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 1900 N 12th Street 015 96, Philadelphia, PA 19122, USA
    J Gen Virol 88:631-40. 2007
    ..Together, our data suggest that Tat-C/EBPbeta association is mediated through cdk9, and that phosphorylated C/EBPbeta may influence AIDS progression by increasing expression of HIV-1 genes...
  38. pmc Regulation of bacteria-induced intercellular adhesion molecule-1 by CCAAT/enhancer binding proteins
    Lori J Manzel
    University of Iowa Carver College of Medicine, Department of Internal Medicine, 200 Hawkins Drive, C33 GH, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 40:200-10. 2009
    ..influenzae...
  39. pmc NF-IL6 (C/EBPbeta) induces HIV-1 replication by inhibiting cytidine deaminase APOBEC3G
    Shigemi M Kinoshita
    Laboratory of Combined Research on Microbiology and Immunology, Research Institute of Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 105:15022-7. 2008
    ..Our findings shed light on the activation of HIV-1 replication by T cell host molecules and reveal a unique regulation of DNA deamination by APOBEC3G and NF-IL6...
  40. pmc NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3
    Seong Ho Lee
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 31:719-28. 2010
    ..These data indicate that C/EBPbeta phosphorylation through GSK3beta may mediate capsaicin-induced expression of NAG-1 and apoptosis through cooperation with ATF3 in human colorectal cancer cells...
  41. ncbi A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
    P Descombes
    Département de Biologie Moléculaire Sciences II, Geneve, Switzerland
    Cell 67:569-79. 1991
    ..The LAP/LIP ratio increases about 5-fold during terminal rat liver differentiation and is thus likely to modulate the activity of LAP in the intact animal...
  42. ncbi LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein
    P Descombes
    Department of Molecular Biology, University of Geneva, Switzerland
    Genes Dev 4:1541-51. 1990
    ..Thus, the preferential accumulation of LAP protein in liver appears to be regulated post-transcriptionally...
  43. pmc Translation start site multiplicity of the CCAAT/enhancer binding protein alpha mRNA is dictated by a small 5' open reading frame
    C F Calkhoven
    Department of Biochemistry, University of Groningen, The Netherlands
    Nucleic Acids Res 22:5540-7. 1994
    ..The presence of a similar, thusfar unnoticed, small ORF 5' to the major initiation codon of C/EBP beta mRNA suggests that start site multiplicity from this mRNA may be governed by the same mechanism...
  44. pmc Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
    T Nakajima
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Proc Natl Acad Sci U S A 90:2207-11. 1993
    ..Mutation of Thr-235 abolished the ras-dependent activation of NF-IL6. From these results, we conclude that NF-IL6 is regulated through phosphorylation by MAP kinases in response to activated ras...
  45. ncbi C/EBP proteins contain nuclear localization signals imbedded in their basic regions
    S C Williams
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Gene Expr 6:371-85. 1997
    ..Finally, we observed that a C/EBPbeta protein lacking its NLS can be localized to the nucleus when coexpressed with C/EBPalpha, indicating that a single NLS is sufficient to promote nuclear transport of a bZIP dimer...
  46. ncbi Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes
    C Xia
    Department of Molecular Pathology, University College London, U K
    Int J Biochem Cell Biol 29:1525-39. 1997
    ..These results suggest the NF-kappa B and C/EBP may form a new complex of transcription factors that mediates the synergistic induction of SAA2 by IL-1 and IL-6...
  47. ncbi Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha
    M Buck
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell 4:1087-92. 1999
    ..Thus, a site-specific phosphorylation of the transcription factor C/EBP beta is critical for hepatocyte proliferation induced by TGF alpha and other stimuli that activate RSK...
  48. pmc Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha
    M Buck
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 20:6712-23. 2001
    ..Treatment of TNF-alpha mice with antioxidants or NOS inhibitors prevented phosphorylation of C/EBPbeta on Ser239 and its nuclear export, and rescued the abnormal albumin gene expression...
  49. ncbi Ras induces mediator complex exchange on C/EBP beta
    Xianming Mo
    Max Delbruck Center for Molecular Medicine, Robert Roessle Str 10, 13092 Berlin, Germany
    Mol Cell 13:241-50. 2004
    ..These results show that a Ras-induced structural alteration of C/EBPbeta determines differential gene activation through selective interaction with distinct Mediator complexes...
  50. ncbi Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence
    Chin Chen
    Department of Biochemistry and Molecular Biology, Center for Mammalian Genetics, and Center for Nutritional Sciences, University of Florida College of Medicine, Gainesville, FL 32610 0245, USA
    J Biol Chem 279:27948-56. 2004
    ..Consistent with those data, overexpression of XBP-1 caused an increase in transcription that was mediated by the C/EBPbeta mammalian unfolded protein response element...
  51. ncbi Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone
    Hong Chen
    Department of Biochemistry and Molecular Biology, Genetics Institute, and Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 279:50829-39. 2004
    ..The data suggest that ATF3-FL and C/EBPbeta act as transcriptional suppressors for the ASNS gene to counterbalance the transcription rate activated by ATF4 following amino acid deprivation...
  52. pmc TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    Nobumichi Ohoka
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, Japan
    EMBO J 24:1243-55. 2005
    ..These results indicate that TRB3 is a novel target of CHOP/ATF4 and downregulates its own induction by repression of CHOP/ATF4 functions, and that it is involved in CHOP-dependent cell death during ER stress...
  53. ncbi Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients
    Jumpei Homma
    Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Oncol Rep 15:595-601. 2006
    ..The data imply that the comparison of C/EBP beta expression could be a prognostic marker for patients with glioma...
  54. doi Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPbeta is involved in PMA-induced monocyte differentiation
    Mi Hee Park
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609 735, Republic of Korea
    FEBS Lett 582:415-22. 2008
    ..These results suggest that Pyk2 is induced and involved in monocyte differentiation and C/EBPbeta is a critical regulator of the Pyk2 expression...
  55. pmc Regulation of the MAD1 promoter by G-CSF
    Kan Jiang
    Institut fur Biochemie, Universitatsklinikum, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
    Nucleic Acids Res 36:1517-31. 2008
    ..Our findings provide the base for the characterization of additional signal transduction pathways that control the expression of MAD1...
  56. doi CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis
    Mitsumasa Hayashida
    Kyushu University, Fukuoka, Japan
    Arthritis Rheum 60:708-16. 2009
    ..To determine the function of CCAAT/enhancer binding protein beta (C/EBPbeta) in the expression of matrix metalloproteinase 13 (MMP-13) in chondrocytes in inflammatory arthritis...
  57. pmc Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2
    Michael Koslowski
    Department of Internal Medicine III, Experimental and Translational Oncology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Biol Chem 284:28607-15. 2009
    ..Our findings provide first insight into a novel and hitherto unknown regulatory mechanism governing selective activation of trophoblast-specific gene expression in breast cancer...
  58. doi C/EBPbeta enhances NF-kappaB-associated signalling by reducing the level of IkappaB-alpha
    Christian Cappello
    Institute of Clinical Chemistry, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cell Signal 21:1918-24. 2009
    ..C/EBPbeta may belong to the group of proteins in the regulatory machinery which adjusts the IkappaB-alpha level in different cell types under various conditions with physiological and pathophysiological implications...
  59. pmc Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code
    Elisabeth Kowenz-Leutz
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    EMBO J 29:1105-15. 2010
    ..Thus, phosphorylation of the transcription factor C/EBPbeta couples ras signalling to arginine methylation and regulates the interaction of C/EBPbeta with epigenetic gene regulatory protein complexes during cell differentiation...
  60. pmc The C/EBPbeta isoform, liver-inhibitory protein (LIP), induces autophagy in breast cancer cell lines
    Maria M Abreu
    Department of Cancer Biology, 752 Preston Research Building, Vanderbilt University, Nashville, TN 37232, USA
    Exp Cell Res 316:3227-38. 2010
    ..Our work shows that C/EBPbeta isoform, LIP, is another member of the group of transcription factors, including E2F1 and p53, which are capable of playing a role in autophagy...
  61. pmc LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis
    Huili Li
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Mol Cancer 10:100. 2011
    ....
  62. pmc CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength
    Lorna W Harries
    Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    Aging Cell 11:262-8. 2012
    ..This association may be consistent with mouse model evidence of CEBPB-triggered muscle repair: if this mechanism is confirmed, it may provide a target for intervention to protect and enhance aging muscle...
  63. ncbi Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta
    M Wegner
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648
    Science 256:370-3. 1992
    ..Phosphorylation of serine at position 276 within the leucine zipper of C/EBP beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP beta...
  64. ncbi Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
    Z Cao
    Department of Embryology, Howard Hughes Research Laboratories, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Genes Dev 5:1538-52. 1991
    ..The temporal pattern of expression of these three C/EBP isoforms during adipocyte differentiation may reflect the underpinnings of a regulatory cascade that controls the process of terminal cell differentiation...
  65. pmc A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
    S Akira
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    EMBO J 9:1897-906. 1990
    ....
  66. ncbi NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines
    H Shimizu
    Department of Molecular Pathology, Kanazawa University, Ishikawa, Japan
    Gene 149:305-10. 1994
    ....
  67. pmc The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein
    G Scala
    Department of Biochemistry and Biomedical Technology, Medical School, University Federico II, Naples, Italy
    J Exp Med 179:961-71. 1994
    ..These results suggest that TAT protein may play a role in the pathogenesis of some HIV1-associated diseases by modulating the expression of host cellular genes...
  68. pmc CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
    D E Zhang
    Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 16:1231-40. 1996
    ..Furthermore, they demonstrate physical and functional interactions between AML1 and C/EBP transcription factor family members...
  69. pmc Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification
    A M Ford
    Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, United Kingdom
    Proc Natl Acad Sci U S A 93:10838-43. 1996
    ....
  70. ncbi HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein beta (NF-IL6) transcription factors
    C Ambrosino
    Department of Clinical and Experimental Medicine, Medical School, University of Reggio Calabria, 88100 Catanzaro, Italy
    J Biol Chem 272:14883-92. 1997
    ..In addition, Tat may function by protein-protein interactions, leading to the generation of heterodimers with specific transcription factors...
  71. pmc Interaction and functional collaboration of p300 and C/EBPbeta
    S Mink
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    Mol Cell Biol 17:6609-17. 1997
    ....
  72. ncbi Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo
    E V Maytin
    Department of Dermatology, Massachusetts General Hospital, Boston 02114, USA
    J Invest Dermatol 110:238-46. 1998
    ..In summary, C/EBP are expressed in a differentiation-associated manner in the skin, and may play an important role in regulating one or more aspects of the epidermal differentiation program...
  73. ncbi Inhibition of CCAAT/enhancer-binding protein alpha and beta translation by upstream open reading frames
    A J Lincoln
    Advanced BioScience Laboratories Basic Research Program, NCI Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    J Biol Chem 273:9552-60. 1998
    ..Our data indicate that the uORFs regulate translation of full-length C/EBPalpha and C/EBPbeta and do not play a role in generating truncated forms of these proteins, as has been suggested by start site multiplicity models...
  74. pmc CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy
    L E Greenbaum
    Department of Genetics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    J Clin Invest 102:996-1007. 1998
    ..These data link C/EBPbeta to the activation of metabolic and growth response pathways in the regenerating liver and demonstrate that C/EBPbeta is required for a normal proliferative response...
  75. ncbi AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor
    M Boruk
    Department of Biochemistry, University of Ottawa, Ottawa Civic Hospital Loeb Research Institute, Ontario, Canada
    Mol Endocrinol 12:1749-63. 1998
    ..Thus, the potentiation of C/EBP beta-mediated transcription by GR would appear to require the presence of an intermediary factor...
  76. ncbi A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes
    E Kowenz-Leutz
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Federal Republic of Germany
    Mol Cell 4:735-43. 1999
    ..Interaction between C/EBP beta and SWI/SNF is essential for activating a subgroup of resident target genes in chromatin and may represent a major determinant of combinatorial gene regulation in eukaryotes...
  77. pmc Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites
    W Xiong
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0643, USA
    Nucleic Acids Res 29:3087-98. 2001
    ..We propose that formation of C/EBPbeta isoforms is accomplished by a leaky ribosomal scanning mechanism that facilitates ATI of multiple internal AUGs...
  78. ncbi ERK2- and p90(Rsk2)-dependent pathways regulate the CCAAT/enhancer-binding protein-beta interaction with serum response factor
    M Hanlon
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:38449-56. 2001
    ..Finally, we demonstrate a requirement for p90(Rsk2) in regulation of C/EBPbeta-SRF interaction. These data show that multiple Ras effectors are required to regulate C/EBPbeta and SRF association...
  79. ncbi C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival
    M Buck
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 8:807-16. 2001
    ..C/EBPbeta-/- and C/EBPbeta-Ala(217) stellate cells were rescued from apoptosis by the cell permeant KE(217)VD tetrapeptide or C/EBPbeta-Glu(217)...
  80. ncbi Organization of the promoter region of the human NF-IL6 gene
    Yingmei Yang
    Department of Chemistry, Purdue University, 1393 Brown Building, West Lafayette, IN 47907 1393, USA
    Biochim Biophys Acta 1577:102-8. 2002
    ..In functional assays, the potential CREB site responded to cellular stimulation. The region that interacted with SP1 and SP3 augmented the overall level of activity produced in response to LPS+PMA...
  81. pmc Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia
    Xiaojuan Liu
    Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
    J Biol Chem 277:39312-9. 2002
    ..This study illustrates a novel role for HIV-1 tat in inducing the expression of iNOS in human astrocytes that may participate in the pathogenesis of HIV-associated dementia...
  82. ncbi Regulation of HIV-1 transcription by NF-IL6 in activated Jurkat T cells
    Anissa E Buckner
    Department of Chemistry, Purdue University, 1393 Brown Building, W Lafayette, IN 47907, USA
    Virus Res 89:53-63. 2002
    ..The results implied that the basal region of HIV-1 LTR includes molecular properties that support activation of HIV-1 by NF-IL6 in stimulated cells...
  83. ncbi An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis
    Catherine Ménard
    Centre for Neuronal Survival and Brain Tumor Research Centre, Montreal Neurological Institute, Montreal, Canada
    Neuron 36:597-610. 2002
    ..Thus, activation of a MEK-C/EBP pathway enhances neurogenesis and inhibits gliogenesis, thereby providing a mechanism whereby growth factors can selectively bias progenitors to become neurons during development...
  84. pmc The Papillomavirus E2 protein binds to and synergizes with C/EBP factors involved in keratinocyte differentiation
    Dirk Hadaschik
    Institute of Virology, University of Cologne, Germany
    J Virol 77:5253-65. 2003
    ..Our data suggest that E2, via its interaction with C/EBP factors, may contribute to enhancing keratinocyte differentiation, which is suppressed by the viral oncoproteins E6 and E7 in HPV-induced lesions...
  85. ncbi Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta
    Marion Weber
    Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universitat, 81675 Munchen, Germany
    J Biol Chem 278:23586-93. 2003
    ....
  86. ncbi Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3
    Erin M Eaton
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:33416-21. 2003
    ..The sumoylation of C/EBP beta-1 is likely to be important in the functional differences observed between C/EBP beta-1 and C/EBP beta-2...
  87. ncbi Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins
    Karin Milde-Langosch
    Institute of Pathology, Department of Gynecopathology, University Hospital Hamburg Eppendorf UKE, Hamburg, Germany
    Breast Cancer Res Treat 79:175-85. 2003
    ..These results suggest that high C/EBPbeta expression might be involved in tumor progression and indicative of an unfavorable prognosis...
  88. ncbi Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL6 3'UTR
    Ding Gan Liu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 13:509-14. 2003
    ..Therefore, our results imply that this 3'untranslated region may have played role of a regulator of gene expression profile...
  89. ncbi Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells
    Yan Ji
    Department of Pathology and Laboratory Medicine, The University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07013, USA
    Cancer Res 64:370-7. 2004
    ....
  90. pmc Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells
    Brenda R Baldwin
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Mol Cell Biol 24:3682-91. 2004
    ..CUG-BP1 is thus a previously unidentified downstream target of EGFR signaling and represents a new translational regulator of LIP expression in human mammary epithelial cells...
  91. ncbi Cooperative interaction of C/EBP beta and Tat modulates MCP-1 gene transcription in astrocytes
    Selvajothi Abraham
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, 015 96, Room 203, Philadelphia, PA 19122, USA
    J Neuroimmunol 160:219-27. 2005
    ....
  92. pmc Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta
    M Carmen Carmona
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, E 08028 Barcelona, Catalunya, Spain
    Biochem J 389:47-56. 2005
    ..In summary, defective thermoregulation owing to the lack of C/EBPbeta is associated with the reduced capacity to supply fatty acids as fuels to sustain brown fat thermogenesis...
  93. ncbi Expression, hormonal regulation, and subcellular localization of CCAAT/enhancer-binding protein-beta in rat and human thyrocytes
    Martine Pomerance
    Institut National de la Santé et de la Recherche Médicale Université Paris XI, Faculte de Pharmacie, Chatenay Malabry, France
    Thyroid 15:197-204. 2005
    ..These data suggest that this factor may play important roles in the regulation of thyroidspecific genes and processes, and that its functions are altered in human thyroid carcinoma...
  94. ncbi Glucocorticoids increase C/EBPbeta activity in the lung epithelium via phosphorylation
    Tove Berg
    Department of Medicine, Division for Respiratory Medicine, Karolinska Institute, Lung Research Laboratory, Karolinska University Hospital, Solna, Sweden
    Biochem Biophys Res Commun 334:638-45. 2005
    ..Together this shows that glucocorticoids increase DNA-binding activity of C/EBPbeta via post-translational mechanism(s) involving phosphorylation...
  95. pmc Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells
    Clara Guerzoni
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson Medical College, 233 South and 10th Street, Philadelphia, PA 19107, USA
    Blood 107:4080-9. 2006
    ....
  96. ncbi NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma
    Leticia Quintanilla-Martinez
    Institute of Pathology, GSF National Research Center for Health and Environment, Neuherberg, Germany
    Blood 108:2029-36. 2006
    ..We suggest that C/EBPbeta is likely to play an important role in the pathogenesis and unique phenotype of this lymphoma...
  97. ncbi C/EBP beta blocks p65 phosphorylation and thereby NF-kappa B-mediated transcription in TNF-tolerant cells
    Andreas Zwergal
    Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, D 81675 Munich, Germany
    J Immunol 177:665-72. 2006
    ..These results define a new molecular mechanism responsible for TNF tolerance in monocytic cells that may contribute to the unresponsiveness seen in patients with sepsis...
  98. ncbi C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells
    Roger R Gomis
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Cell 10:203-14. 2006
    ..We suggest that C/EBPbeta plays a key role in the coordination of TGFbeta cytostatic gene responses, and its malfunction may trigger evasion of these responses in breast cancer...
  99. pmc Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes
    Roberto Piva
    Department of Pathology and Center for Experimental Research and Medical Studies CeRMS, University of Turin, Turin, Italy
    J Clin Invest 116:3171-82. 2006
    ..Thus, we proved that an experimentally controlled and functionally validated GEP analysis represents a powerful tool to identify novel pathogenetic networks and validate biologically suitable target genes for therapeutic interventions...
  100. ncbi CCAAT enhancer-binding protein beta regulates constitutive gene expression during late stages of monocyte to macrophage differentiation
    Thu Hang Pham
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    J Biol Chem 282:21924-33. 2007
    ..Our data suggest an important constitutive gene regulatory function for C/EBPbeta in differentiated macrophages but not in human blood monocytes...
  101. pmc G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta
    Ole Pless
    Max Delbruck Center for Molecular Medicine, Humboldt University of Berlin, Berlin, Germany
    J Biol Chem 283:26357-63. 2008
    ..Our data identify C/EBPbeta as a direct substrate of G9a-mediated post-translational modification that alters the functional properties of C/EBPbeta during gene regulation...

Research Grants68

  1. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
    ..Functional characterization of the C/EBPB isoforms and the receptor tyrosine kinase pathways that regulate their expression will further our understanding of the molecular basis of mammary development and tumorigenesis. ..
  2. DHAN V KALVAKOLANU; Fiscal Year: 2014
    ..Studies proposed in this application will investigate the regulation of an anti-metastatic gene, DAPK1, which is critical for tumor suppression and autophagic responses. ..
  3. Kezhong Zhang; Fiscal Year: 2016
    ..Understanding the stress-induced molecular mechanisms in hepatic lipid accumulation and its associated pathogenesis is a key prerequisite for the development of new diagnostics and therapeutics targeting NAFLD. ..
  4. IL-17-Induced Regulation of C/EBPbeta
    MICHELLE ROSAN SIMPSON-ABELSON; Fiscal Year: 2012
    ..This proposed research will study the effects of IL-17 on mediating the alternative translation of the transcription factor C/EBP?, an event that is known to modulate IL- 17-mediated signaling. ..
  5. Gene Expression in Long-term Memory
    Cristina M Alberini; Fiscal Year: 2011
    ....
  6. C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVAL
    Mario Chojkier; Fiscal Year: 2012
    ..These studies are relevant to the hepatocyte proliferation and survival characteristic of many physiological and pathological conditions, including hepatocellular injury, liver regeneration and hepatocellular carcinoma. ..
  7. Huizhi Wang; Fiscal Year: 2014
    ....
  8. C/EBP BETA TRANSLATION PRODUCTS IN MAMMARY EPITHELIUM
    Julie Hutt; Fiscal Year: 2002
    ..The Department of Veterinary Biosciences is a highly productive research-oriented professional training environment. ..
  9. Liver Lung Interactions in Lung Inflammation
    Brian Christman; Fiscal Year: 2006
    ..Activation of two transcription factors, nuclear factor kappa B (NFkB) and CCAAT enhancer binding protein beta (C/EBPbeta a.k.a...
  10. LIVER-LUNG INTERACTIONS FOLLOWING LIVER INJURY
    LEONARD WUDEL; Fiscal Year: 2002
    ..cytokines involves activation of two transcription factors, nuclear factor kappa B (NF-kappa B) and CCAAT enhancer binding protein beta (C/EBPbeta, also known as NF-IL6) and activation is well-documented in several inflammatory states...
  11. Bayar Thimmapaya; Fiscal Year: 2016
    ....
  12. C/EBP beta Peptides for the Treatment of Hepatic Fibrosis
    Mario Chojkier; Fiscal Year: 2010
    ..Development of effective treatments for liver fibrosis may also facilitate future treatments for lung and kidney fibrosis. ..
  13. Hormone-Regulated Pathways Controlling Implantation and Fertility
    Milan K Bagchi; Fiscal Year: 2012
    ..They should also aid in developing new molecular diagnostic tools for screening endometrial dysfunction and enable targeted therapeutic strategies for the treatment of infertility. ..
  14. Regulation of glucose homeostasis by C/EBPB
    Jacob E Friedman; Fiscal Year: 2010
    ....
  15. C/EBP-beta PEPTIDES FOR THE TREATMENT OF LIVER INJURY AND FIBROSIS
    Mario Chojkier; Fiscal Year: 2013
    ..There is no medication for the treatment or prevention of liver fibrosis. Completion of these tasks for the proposed compounds will allow us proceeding with a Phase-2 STTR and clinical development in patients with liver fibrosis. ..
  16. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    ....
  17. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    ..A related and longer term goal of the research is to identify and characterize the genes regulated by LH, prostaglandins (PGs), and C/EBPs that control key steps in the ovulatory process. ..
  18. P20, 'MOLECULAR SHORTSTOP' FOR INFLAMATORY LUNG DISEASES
    Kenneth Brigham; Fiscal Year: 2000
    ..This concept could provide a new therapeutic approach to a host of inflammatory lung diseases, including idiopathic pulmonary fibrosis, ARDS, cystic fibrosis and asthma. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  19. Role of Egr-1 in post-stroke inflammation & brain damage
    Raghu Vemuganti; Fiscal Year: 2009
    ..The ultimate goal is to define the role of EgM and its regulators to develop therapies to control cerebral inflammation at the level of transcription. ..
  20. Role of Cysteine-rich Protein 2 in Vascular Disease
    Shaw Fang Yet; Fiscal Year: 2005
    ..abstract_text> ..
  21. REGULATION OF THE HUMAN INOS GENE IN SEPSIS AND TRAUMA
    David Geller; Fiscal Year: 2007
    ..abstract_text> ..
  22. Elimination of Carcinogen-Induced Tumor Stem Cells by ATF5 Loss of Function.
    JAMES ANGELASTRO; Fiscal Year: 2009
    Activating transcription factor 5 (ATF5) is highly expressed in neural stem/progenitor cells, and disappears when these cells differentiate into neurons and astrocytes...
  23. In Vivo Trapping of Genes Involved in Ovulation
    Lane Christenson; Fiscal Year: 2005
    ..These studies will for the first time determine the mechanism and cell signaling pathways by which the Cebpb transcription factor promotes ovulation. ..
  24. Mechanisms of p53 action on primate steroidogenesis
    CHARLES CHAFFIN; Fiscal Year: 2005
    ..The proposed studies are expected to demonstrate a novel role for the tumor suppressor p53 in the onset of primate and human steroidogenesis. ..
  25. ALTERED C/EBPB REGULATION IN IPF LUNG FIBROBLASTS
    Roberto Cruz Gervis; Fiscal Year: 2003
    ..This work could provide a rationale for treatment of IPF with either the p20C/EBPbeta protein or the gene encoding this C/EBPbeta isoform. ..
  26. Molecular interactions: oral bacteria & matrix proteins
    Keith Mintz; Fiscal Year: 2010
    ..Understanding how bacteria interact with host cells or tissue constituents will aid in the development of novel therapeutics to prevent initiation or progression of the disease. ..
  27. Mechanisms of glomerular disesase progression
    Jeffrey R Schelling; Fiscal Year: 2012
    ....
  28. Mechanisms of Acceptance in Mouse Renal Allografts
    Robert B Colvin; Fiscal Year: 2013
    ....
  29. David A Boothman; Fiscal Year: 2016
    ..In either case, use of NQO1 bioactivatable drugs will lend tumor-selectivity to DNA repair inhibitors, whose efficacy has been limited due to lack of specificity. ..
  30. EDWARD THOMAS LALLY; Fiscal Year: 2016
    ..The outcomes of toxin/membrane interactions will be assessed by biochemical, biophysical and morphological assays. ..
  31. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..This work may aid in the development of behavioral and pharmacological treatment strategies to reduce the incidence of co-morbid PTSD and alcohol use disorders. ..
  32. Rhodopsin endocytic trafficking and Drosophila visual sensitivity
    Hong Sheng Li; Fiscal Year: 2010
    ..These processes regulate the intensity of GPCR signaling, and have been implicated in clinical disorders such as retinal degenerations and opioid tolerance. ..
  33. Phosphodiesterease-4 (PDE4) as a Novel Target to Reduce Ethanol Consumption
    Han Ting Zhang; Fiscal Year: 2012
    ..Therefore, the issue expected to be resolved in this proposal is of importance and considerable relevance to public health. ..
  34. Environmental Adaptation and Membrane Physiology of an Oral Pathogen
    KEITH PETER MINTZ; Fiscal Year: 2013
    ..Understanding the fundamental properties of the physiology and structure of these pathogens will aid in the development of medicines which interrupt the life cycle of these microorganisms and prevent bacterial infections. ..
  35. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard L Stouffer; Fiscal Year: 2010
    ..abstract_text> ..
  36. Steven B Abramson; Fiscal Year: 2014
    ..Understanding the regulation of chondrocyte functions by F-spondin could lead to novel strategies for cartilage repair and disease modifying treatments for osteoarthritis. ..
  37. Michael Croft; Fiscal Year: 2016
    ....
  38. Functions of Lactoferrin Polymorphisms in an Oral Infection
    Kabilan Velliyagounder; Fiscal Year: 2011
    ....
  39. Richard S Blumberg; Fiscal Year: 2016
    ..Such knowledge is expected to identify new strategies for targeting the immune system in the goal of inhibiting inflammation or enhancing anti-tumor and anti-infective immunity. ..
  40. Oral Colonization of Aggregatibacter in Primates
    Daniel H Fine; Fiscal Year: 2012
    ....
  41. Wheelchair with drop down armrest for sliding transfers by user
    ROBERT KENT OSBORN; Fiscal Year: 2011
    ..The purpose of this project is to develop easily installed flip back armrests that can be lowered with one hand to be used as attached transfer boards that never fall or get misplaced. ..
  42. Daniel B Rifkin; Fiscal Year: 2016
    ..The results may suggest mechanisms for normalizing TGF-[unreadable] in certain pathological states, such as lung fibrosis. ..
  43. Role of Integrins/ECM in Controlling IGF-I Actions
    David Robert Clemmons; Fiscal Year: 2013
    ..abstract_text> ..
  44. Proteomic Dissection of Withdrawal-Induced Excessive Drinking
    Christine C Wu; Fiscal Year: 2010
    ....
  45. Cytotoxic mechanisms of Aggregatibacter actinomycetemcomitans leukotoxin
    Angela C Brown; Fiscal Year: 2013
    ....
  46. Phillip B Messersmith; Fiscal Year: 2015
    ....
  47. Characterization of LC3-Associated Phagocytosis
    Jennifer Martinez; Fiscal Year: 2013
    ..Further understanding the mechanisms by which autophagy, or in this case, LAP, can be triggered will provide researchers with novel therapeutic targets to the treatment of cancer. ..
  48. Identification and Function of Receptors and Ligands
    John G Flanagan; Fiscal Year: 2011
    ..abstract_text> ..
  49. Hypoxia and PMN Function in Periodontitis
    IBRAHIM ALPDOGAN KANTARCI; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: This proposal will determine the mechanism of PMN superoxide release in response to hypoxia-mediated inflammation and the potential treatment by RvE1. ..
  50. Engineering Functional Brown Fat with Anti-Obesity Potential
    Shingo Kajimura; Fiscal Year: 2013
    ..abstract_text> ..
  51. Stephen L Nishimura; Fiscal Year: 2015
    ..Overall goal: To identify genetic markers for pharmacogenetic targeting of [unreadable]v[unreadable]8 in COPD patients. ..
  52. DAT QUOC TRAN; Fiscal Year: 2016
    ....
  53. Interaction of Aggregatibacter actinomycetemcomitans leukotoxin with membranes
    Angela C Brown; Fiscal Year: 2012
    ..This study will allow determination of the role of the physical properties of the membrane, specifically curvature, on LtxA-induced membrane disruption, and will establish the mechanism of this disruption. ..
  54. Tight Adherence Genes of a Periodontal Pathogen
    David H Figurski; Fiscal Year: 2012
    ..These chemicals may be developed into new antibiotic drugs, supporting therapy for multiple types of infection. ..
  55. SURGERY FOR NEC IN HUMAN INFANTS-- A RANDOMIZED TRIAL
    R Moss; Fiscal Year: 2002
    ..We believe that we have the necessary personnel and resources in place to complete the first randomized controlled trial for neonatal surgery in the United States. ..
  56. John O L Delancey; Fiscal Year: 2014
    ..These results will provide critical insights needed to reduce operative failures by providing a more accurate understanding of the pathomechanics of AC prolapse. ..
  57. Continuous Cardiac Output & Filling Pressure Monitoring
    Ramakrishna Mukkamala; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. TGFB AND GENE THERAPY IN SILICA INDUCED LUNG FIBROSIS
    Patricia Sime; Fiscal Year: 2005
    ..In conjunction with a formal education program me this should allow her to successfully develop as an independent investigator, while yielding new insights into the pathogenesis and treatment of fibrotic pathologies. ..
  59. Activation of latent TGF-beta by integrins
    JOHN MUNGER; Fiscal Year: 2007
    ..These studies will further delineate the role of RGD-binding integrins in TGFbeta biology and provide a basis for important studies of their role in lung pathology. ..
  60. Epidemiology of Indoor Air Pollution and Human Health
    Seppo Rinne; Fiscal Year: 2006
    ..Through these investigations we hope to provide insight into an environmental hazard that is widespread throughout the world. ..
  61. COMBINATORIAL & RATIONAL DESIGN APTAMERS TARGETING HIV
    David Gorenstein; Fiscal Year: 2004
    ..abstract_text> ..
  62. Immunogenetics and LAP susceptibility
    Grant Gallagher; Fiscal Year: 2004
    ..Additionally, the data harvested from these studies should allow earlier treatment of disease and enhance our understanding of the molecular mechanisms underlying the pathogenesis of LAP and other forms of periodontitis. ..
  63. REGULATION OF CELL DEATH IN DROSOPHILA
    Bruce Hay; Fiscal Year: 2006
    ..Finally, we will also characterize the roles and mechanism of action of a second Drosophila lAP, DIAP2. ..
  64. Aging /Caloric Restriction /Cytosolic Protease
    Maria Gaczynska; Fiscal Year: 2002
    ..These studies will provide us with detailed pattern of age- dependent and caloric restriction-dependent changes in cellular nonlysosomal controlled proteolysis. ..
  65. Stat5 dephosphorylation by Shp-2
    Demin Wang; Fiscal Year: 2007
    The signal transducer and activator of transcription factor 5 (Stat5) plays a very important role in functions of a broad spectrum of cytokines...
  66. Immune mechanisms that lead to irreversible scleroderma
    Anita Gilliam; Fiscal Year: 2007
    ..Developing more effective diagnostic tools and immunomodulatory therapies for early scleroderma is the ultimate goal of this research. ..
  67. MECHANISM OF CYTOKINE INDUCED B CELL DIFFERENTIATION
    Selina Chen Kiang; Fiscal Year: 2000
    ..These studies should provide significant insight into the the mechanisms that underlie cytokine signaling in the immune system and terminal differentiation of B cells. ..