CA2

Summary

Gene Symbol: CA2
Description: carbonic anhydrase 2
Alias: CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282, carbonic anhydrase 2, carbonate dehydratase II, carbonic anhydrase B, carbonic anhydrase C, carbonic anhydrase II, carbonic dehydratase, epididymis luminal protein 76, epididymis secretory protein Li 282
Species: human
Products:     CA2

Top Publications

  1. Sly W, Hu P. Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995;64:375-401 pubmed
    ..Analyses of human and animal CA deficiencies provide unique opportunities to understand the individual contributions of different isozymes to these processes. ..
  2. Li X, Alvarez B, Casey J, Reithmeier R, Fliegel L. Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger. J Biol Chem. 2002;277:36085-91 pubmed
    We examined the ability of carbonic anhydrase II to bind to and affect the transport efficiency of the NHE1 isoform of the mammalian Na(+)/H(+) exchanger...
  3. Perni S, Lavorato M, Beam K. De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+ release. Proc Natl Acad Sci U S A. 2017;114:13822-13827 pubmed publisher
    ..1 and RyR1. Thus, these proteins constitute the key elements essential for excitation-contraction coupling in skeletal muscle. ..
  4. Ma G, Wen S, Huang Y, Zhou Y. The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels. Adv Exp Med Biol. 2017;993:117-138 pubmed publisher
    ....
  5. Martineau X, Abed E, Martel Pelletier J, Pelletier J, Lajeunesse D. Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts. PLoS ONE. 2017;12:e0180711 pubmed publisher
    ..These data indicate that the alteration of Wnt5a, a non-canonical Wnt signaling activator, is implicated in the modified signalisation and phenotype observed in OA Ob. ..
  6. Elattar S, Estaphan S, Mohamed E, Elzainy A, Naguib M. The protective effect of 1alpha, 25-dihydroxyvitamin d3 and metformin on liver in type 2 diabetic rats. J Steroid Biochem Mol Biol. 2017;173:235-244 pubmed publisher
    ..Eight weeks later, serum glucose and insulin levels were measured, HOMA IR was calculated, lipid profile, Ca2+, ALT and AST were estimated...
  7. Robertson D, Paki B. Role of L-type Ca2+ channels in transmitter release from mammalian inner hair cells. II. Single-neuron activity. J Neurophysiol. 2002;87:2734-40 pubmed
    ..sound-evoked cochlear potentials after intracochlear perfusion of nimodipine suggest that dihydropyridine-sensitive Ca2+ channels (L-type) control the sound-evoked release of transmitter from the inner hair cells of the mammalian ..
  8. Alvarez B, Vilas G, Casey J. Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 2005;24:2499-511 pubmed
    ..Cl-/HCO3- exchanger with a suggested role in pancreatic HCO3- secretion, was found to bind the cytoplasmic enzyme CAII. Mutation of the identified CAII binding (CAB) site greatly reduced SLC26A6 activity, demonstrating the importance ..
  9. Samad N, Ishaq S, Bano S, Manzoor N. Calcium Regulation in Alzheimer's Disease: Mechanistic Understanding. J Coll Physicians Surg Pak. 2017;27:566-571 pubmed publisher
    This study is systematic review of the research, focused on all possible pathways involved in calcium (Ca2+) regulation in order to utilize them in the control and remediation of Alzheimer's disease (AD), because Ca2+ plays important ..
  10. Järvinen P, Kivela A, Nummela P, Lepistö A, Ristimaki A, Parkkila S. Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei. APMIS. 2017;125:207-212 pubmed publisher
    Altered expression of carbonic anhydrase (CA) II is associated with human carcinogenesis. We analysed CA II protein expression in 89 patients with pseudomyxoma peritonei (PMP) and correlated its association against survival...

Detail Information

Publications62

  1. Sly W, Hu P. Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995;64:375-401 pubmed
    ..Analyses of human and animal CA deficiencies provide unique opportunities to understand the individual contributions of different isozymes to these processes. ..
  2. Li X, Alvarez B, Casey J, Reithmeier R, Fliegel L. Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger. J Biol Chem. 2002;277:36085-91 pubmed
    We examined the ability of carbonic anhydrase II to bind to and affect the transport efficiency of the NHE1 isoform of the mammalian Na(+)/H(+) exchanger...
  3. Perni S, Lavorato M, Beam K. De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+ release. Proc Natl Acad Sci U S A. 2017;114:13822-13827 pubmed publisher
    ..1 and RyR1. Thus, these proteins constitute the key elements essential for excitation-contraction coupling in skeletal muscle. ..
  4. Ma G, Wen S, Huang Y, Zhou Y. The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels. Adv Exp Med Biol. 2017;993:117-138 pubmed publisher
    ....
  5. Martineau X, Abed E, Martel Pelletier J, Pelletier J, Lajeunesse D. Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts. PLoS ONE. 2017;12:e0180711 pubmed publisher
    ..These data indicate that the alteration of Wnt5a, a non-canonical Wnt signaling activator, is implicated in the modified signalisation and phenotype observed in OA Ob. ..
  6. Elattar S, Estaphan S, Mohamed E, Elzainy A, Naguib M. The protective effect of 1alpha, 25-dihydroxyvitamin d3 and metformin on liver in type 2 diabetic rats. J Steroid Biochem Mol Biol. 2017;173:235-244 pubmed publisher
    ..Eight weeks later, serum glucose and insulin levels were measured, HOMA IR was calculated, lipid profile, Ca2+, ALT and AST were estimated...
  7. Robertson D, Paki B. Role of L-type Ca2+ channels in transmitter release from mammalian inner hair cells. II. Single-neuron activity. J Neurophysiol. 2002;87:2734-40 pubmed
    ..sound-evoked cochlear potentials after intracochlear perfusion of nimodipine suggest that dihydropyridine-sensitive Ca2+ channels (L-type) control the sound-evoked release of transmitter from the inner hair cells of the mammalian ..
  8. Alvarez B, Vilas G, Casey J. Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 2005;24:2499-511 pubmed
    ..Cl-/HCO3- exchanger with a suggested role in pancreatic HCO3- secretion, was found to bind the cytoplasmic enzyme CAII. Mutation of the identified CAII binding (CAB) site greatly reduced SLC26A6 activity, demonstrating the importance ..
  9. Samad N, Ishaq S, Bano S, Manzoor N. Calcium Regulation in Alzheimer's Disease: Mechanistic Understanding. J Coll Physicians Surg Pak. 2017;27:566-571 pubmed publisher
    This study is systematic review of the research, focused on all possible pathways involved in calcium (Ca2+) regulation in order to utilize them in the control and remediation of Alzheimer's disease (AD), because Ca2+ plays important ..
  10. Järvinen P, Kivela A, Nummela P, Lepistö A, Ristimaki A, Parkkila S. Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei. APMIS. 2017;125:207-212 pubmed publisher
    Altered expression of carbonic anhydrase (CA) II is associated with human carcinogenesis. We analysed CA II protein expression in 89 patients with pseudomyxoma peritonei (PMP) and correlated its association against survival...
  11. Liu L, Xu W, Wu X, Zhao P, Lv Y, Chen L. Overexpression of carbonic anhydrase II and Ki-67 proteins in prognosis of gastrointestinal stromal tumors. World J Gastroenterol. 2013;19:2473-80 pubmed publisher
    To investigate the expression and prognostic value of carbonic anhydrase II (CA II) and Ki-67 in gastrointestinal stromal tumors (GISTs)...
  12. Zhang Z, Wen Y, Du J, Yu Y, Liu S, Wu X, et al. Effects of mechanical stretch on the functions of BK and L-type Ca2+ channels in vascular smooth muscle cells. J Biomech. 2018;67:18-23 pubmed publisher
    ..Our results suggested that during hypertension, pathological stretch altered the activity of BK and L-type Ca2+ channels and manipulated the calcium oscillation of VSMCs. ..
  13. Bertoli A, Sorgato M. Neuronal pathophysiology featuring PrPC and its control over Ca2+ metabolism. Prion. 2017;: pubmed publisher
    ....
  14. Ahn J, Lee T, Park J, Cho J, Kim I, Lee J, et al. Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils. Lab Anim Res. 2017;33:237-243 pubmed publisher
    ..age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus, CA2/3 and CA1 areas) of gerbils of various ages; young (1 month), adult (6 months) and aged (24 months), using western ..
  15. Szollosi A, Nenquin M, Aguilar Bryan L, Bryan J, Henquin J. Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels. J Biol Chem. 2007;282:1747-56 pubmed
    ..It is suggested that unidentified potassium channels are sensitive to glucose and subserve the acute and long-term metabolic control of [Ca(2+)](c) in beta-cells without functional K(ATP) channels...
  16. Lu T, Chou C, Liang W, Kuo C, Chen I, Wang J, et al. Amitriptyline modulated Ca2+ signaling and induced Ca2+-independent cell viability in human osteosarcoma cells. Hum Exp Toxicol. 2017;:960327117693070 pubmed publisher
    ..Amitriptyline also induced Ca2+-disassociated cell death...
  17. Höst G, Mårtensson L, Jonsson B. Redesign of human carbonic anhydrase II for increased esterase activity and specificity towards esters with long acyl chains. Biochim Biophys Acta. 2006;1764:1601-6 pubmed
    ..the shape and the size of the hydrophobic pocket on the esterase activity and specificity of human carbonic anhydrase II (HCAII) for esters with different acyl chain lengths was investigated...
  18. Reyes Haro D, Labrada Moncada F, Varman D, Krüger J, Morales T, Miledi R, et al. Anorexia Reduces GFAP+ Cell Density in the Rat Hippocampus. Neural Plast. 2016;2016:2426413 pubmed publisher
    ..Thus, the aim of this study was to estimate GFAP+ cell density in the main regions of the hippocampus (CA1, CA2, CA3, and dentate gyrus) in the DIA model...
  19. Cox J, Hunt J, Compher K, Fierke C, Christianson D. Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry. 2000;39:13687-94 pubmed
    Aromatic residues in the hydrophobic core of human carbonic anhydrase II (CAII) influence metal ion binding in the active site. Residues F93, F95, and W97 are contained in a beta-strand that also contains two zinc ligands, H94 and H96...
  20. Chen W, An P, Quan X, Zhang J, Zhou Z, Zou L, et al. Ca2+/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways. World J Gastroenterol. 2017;23:6111-6118 pubmed publisher
    ..To investigate the role of calmodulin-dependent protein kinase II (CaMKII) in colon cancer growth, migration and invasion...
  21. Ruff C, Faulkner S, Rumajogee P, Beldick S, Foltz W, Corrigan J, et al. The extent of intrauterine growth restriction determines the severity of cerebral injury and neurobehavioural deficits in rodents. PLoS ONE. 2017;12:e0184653 pubmed publisher
    ..NeuN staining revealed changes in neuronal density in the hippocampus and in the thickness of hippocampal CA2 and CA3 regions. Diffusion weighted imaging (DWI) revealed regional white and grey matter changes at 3 weeks of age...
  22. Shi C, Uda Y, Dedic C, Azab E, Sun N, Hussein A, et al. Carbonic anhydrase III protects osteocytes from oxidative stress. FASEB J. 2018;32:440-452 pubmed publisher
    ..Considering that CAII was recently identified as being regulated by Sost/sclerostin and capable of controlling mineral homeostasis, we ..
  23. Janssen L, Lu Chao H, Netherton S. Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase. Am J Physiol Lung Cell Mol Physiol. 2001;280:L666-74 pubmed
    ..KCl, caffeine, and cyclopiazonic acid elevated intracellular Ca2+ concentration levels and tone, indicating that Ca2+ mobilization is sufficient to produce contraction...
  24. Patel J, Fitzsimons D, Buck S, Muthuchamy M, Wieczorek D, Moss R. PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin. Am J Physiol Heart Circ Physiol. 2001;280:H2732-9 pubmed
    ..hearts expressing 100% alpha-tropomyosin (alpha-Tm) to examine the effects of phosphorylated TnI and MyBP-C on Ca2+ sensitivity of force and the rate constant of force redevelopment (k(tr))...
  25. Lee J, Maskey D, Kim M. Immunohistochemical Localization of Calbindin D28k, Parvalbumin, and Calretinin in the Superior Olivary Complex of Circling Mice. Cells Tissues Organs. 2017;: pubmed publisher
    ..Several studies have reported that abnormal calcium (Ca2+) homeostasis is associated with the pathology of hearing loss...
  26. Rahman S, Rahman T. Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. Sci Rep. 2017;7:12881 pubmed publisher
    ....
  27. Matsui Y, Sadhu K, Mizukami S, Kikuchi K. Highly selective tridentate fluorescent probes for visualizing intracellular Mg2+ dynamics without interference from Ca2+ fluctuation. Chem Commun (Camb). 2017;53:10644-10647 pubmed publisher
    ..The new probes are potential keys to elucidating intracellular Mg2+ dynamics under conditions of extremely sharp Ca2+ fluctuation. ..
  28. Murakami H, Marelich G, Grubb J, Kyle J, Sly W. Cloning, expression, and sequence homologies of cDNA for human carbonic anhydrase II. Genomics. 1987;1:159-66 pubmed
    ..The deduced amino acid sequence is identical to that reported for human CA II. The protein coding region of this cDNA for human CA II shows 81 and 70% nucleotide identity with cDNAs for CA II ..
  29. Bögeholz N, Schulte J, Kaese S, Bauer B, Pauls P, Dechering D, et al. The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models. Front Pharmacol. 2017;8:649 pubmed publisher
    ..Thus, the remaining NCX function under inhibition may be a critical factor determining the inotropic and antiarrhythmic efficacy of SEA0400...
  30. Liao L, Shang L, Li N, Wang S, Wang M, Huang Y, et al. Mixed lineage kinase domain-like protein induces RGC-5 necroptosis following elevated hydrostatic pressure. Acta Biochim Biophys Sin (Shanghai). 2017;49:879-889 pubmed publisher
    ..target, mixed lineage kinase domain-like protein (MLKL), has been proposed to induce necroptosis by initiating Ca2+ influx...
  31. Sahoo N, Gu M, Zhang X, Raval N, Yang J, Bekier M, et al. Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle. Dev Cell. 2017;41:262-273.e6 pubmed publisher
    ....
  32. Krout D, Schaar A, Sun Y, Sukumaran P, Roemmich J, Singh B, et al. The TRPC1 Ca2+-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes. J Biol Chem. 2017;292:20799-20807 pubmed publisher
    ....
  33. Chen Z, Wang C, Zhuo M, Zhai Q, Chen Q, Guo Y, et al. Exome sequencing identified a novel missense mutation c.464G>A (p.G155D) in Ca2+-binding protein 4 (CABP4) in a Chinese pedigree with autosomal dominant nocturnal frontal lobe epilepsy. Oncotarget. 2017;8:78940-78947 pubmed publisher
    ..These findings suggest that mutations in the CABP4 gene may be linked to ADNFLE...
  34. Megha -, Hasan G. Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells. Fly (Austin). 2017;: pubmed publisher
    ..We hypothesise that the cellular energy sensor, AMPK connects IP3R mediated Ca2+ release into the mitochondria, to protein translation, via the TOR pathway...
  35. Musumeci G, Castrogiovanni P, Szychlinska M, Imbesi R, Loreto C, Castorina S, et al. Protective effects of high Tryptophan diet on aging-induced passive avoidance impairment and hippocampal apoptosis. Brain Res Bull. 2017;128:76-82 pubmed publisher
    ..of aged rats and this correlated with a decrease of TUNEL positive cells in all hippocampal regions tested (CA1, CA2, CA3, DG)...
  36. Navaei Bonab R, Kazzazi M, Saber M, Vatanparast M. Differential Inhibition of Helicoverpa armigera (Lep.: Noctuidae) Gut Digestive Trypsin by Extracted and Purified Inhibitor of Datura metel (Solanales: Solanaceae). J Econ Entomol. 2017;: pubmed publisher
    ..Fe2+, Cu2+, and Mn2+ were found to decrease the trypsin inhibitory activity, whereas Hg2+, Mg2+, K+, Zn2+, Na+, Ca2+, and Cd2+ were found to significantly increase the inhibitory effect...
  37. Machaty Z, Wang C, Lee K, Zhang L. Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation. Adv Exp Med Biol. 2017;993:577-593 pubmed publisher
    ....
  38. Dhanka M, Shetty C, Srivastava R. Methotrexate loaded alginate microparticles and effect of Ca2+ post-crosslinking: An in vitro physicochemical and biological evaluation. Int J Biol Macromol. 2017;: pubmed publisher
    ..The biocompatibility and hemocompatibility studies of the microparticles have demonstrated that microparticles are biocompatible and were non-hemolytic at low concentrations...
  39. Al Mamun Bhuyan A, Ashiqul Haque A, Sahu I, Cao H, Kormann M, Lang F. Inhibition of Suicidal Erythrocyte Death by Volasertib. Cell Physiol Biochem. 2017;43:1472-1486 pubmed publisher
    ..Stimulators of eryptosis include energy depletion, hyperosmotic shock, oxidative stress and excessive increase of cytosolic Ca2+ activity ([Ca2+]i). The present study explored, whether volasertib impacts on eryptosis.
  40. Eichner M, Augustin C, Fromm A, Piontek A, Walther W, Bücker R, et al. In colon epithelia, Clostridium perfringens enterotoxin causes focal leaks by targeting claudins which are apically accessible due to tight junction derangement. J Infect Dis. 2017;: pubmed publisher
    ..It uses some claudin tight junction proteins (e.g. claudin-4) as receptors to form Ca2+-permeable pores in the membrane damaging epithelial cells in small intestine and colon...
  41. Ghashghaeinia M, Wesseling M, Ramos E, Petkova Kirova P, Waibel S, Lang E, et al. Trifluoperazine-Induced Suicidal Erythrocyte Death and S-Nitrosylation Inhibition, Reversed by the Nitric Oxide Donor Sodium Nitroprusside. Cell Physiol Biochem. 2017;42:1985-1998 pubmed publisher
    ..Eryptosis can be stimulated by an increase in cytoplasmic Ca2+ concentration ([Ca2+]i) and inhibited by nitric oxide (NO)...
  42. De Simone G, Supuran C. (In)organic anions as carbonic anhydrase inhibitors. J Inorg Biochem. 2012;111:117-29 pubmed publisher
    ..Environmental aspects of CO(2) fixation by CAs present in plants, corals, algae or diatoms and how this may be affected by inhibitors are also discussed. ..
  43. Loos J, Churio M, Cumino A. Anthelminthic activity of glibenclamide on secondary cystic echinococcosis in mice. PLoS Negl Trop Dis. 2017;11:e0006111 pubmed publisher
    ..Our results also revealed mitochondrial membrane depolarization and an increase in intracellular Ca2+ levels in Glb-treated protoscoleces...
  44. Leroy F, Brann D, Meira T, Siegelbaum S. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron. 2017;95:1089-1102.e5 pubmed publisher
    ..We now find that paired stimulation of EC and SC inputs also induces ITDP of SC excitation of CA2 PNs...
  45. Opačić M, Ristic A, Savic D, Selih V, Zivin M, Sokic D, et al. Metal maps of sclerotic hippocampi of patients with mesial temporal lobe epilepsy. Metallomics. 2017;9:141-148 pubmed publisher
    ..in regions/layers with neuron somata - subiculum, CA4, gyrus dentatus, and stratum pyramidale (SPy) in CA1 and CA2. Alveus and other regions with axons and dendrites generally showed lower levels of Zn, Cu, and Mn...
  46. Xie Q, Xu Y, Gao W, Zhang Y, Su J, Liu Y, et al. TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release. Int J Mol Med. 2017;: pubmed publisher
    ..In this study, we observed the cytoplasmic and mitochondrial levels of Ca2+ by confocal laser microscopy. We also detected cell apoptosis using western blot analysis and flow cytometry...
  47. Ye J, Zhao Y, Ju J, Wang W. Building and verifying a severity prediction model of acute pancreatitis (AP) based on BISAP, MEWS and routine test indexes. Clin Res Hepatol Gastroenterol. 2017;41:585-591 pubmed publisher
    ..value of the Bedside Index for Severity in Acute Pancreatitis (BISAP), Modified Early Warning Score (MEWS), serum Ca2+, similarly hereinafter, and red cell distribution width (RDW) for predicting the severity grade of acute ..
  48. Daniel E, Jury J, Wang Y. nNOS in canine lower esophageal sphincter: colocalized with Cav-1 and Ca2+-handling proteins?. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1101-14 pubmed
    ..Those that apparently colocalized with nNOS were L-Ca2+ channels, the PM Ca2+ pump, and, in part, calreticulin and calsequestrin...
  49. Gonçalves P, Meireles S, Neves P, Vale M. Ca2+ sensitivity of synaptic vesicle dopamine, gamma-aminobutyric acid, and glutamate transport systems. Neurochem Res. 2001;26:75-81 pubmed
    The effect of Ca2+ on the uptake of neurotransmitters by synaptic vesicles was investigated in a synaptic vesicle enriched fraction isolated from sheep brain cortex...
  50. Webster K, Bishopric N. Molecular aspects and gene therapy prospects for diastolic failure. Cardiol Clin. 2000;18:621-35 pubmed
    ..Augmenting the activity of the SR Ca2+ ATPase by AAV-mediated delivery of the SERCA2a gene, directed by a cardiac-specific promoter with a tightly ..
  51. Xia Z, Wei J, Li Y, Wang J, Li W, Wang K, et al. Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis. PLoS Genet. 2017;13:e1006892 pubmed publisher
    ..Interestingly, prior to the onset of slc30a10 expression, expressing ATP2C1 (ATPase secretory pathway Ca2+ transporting 1) protected mutant embryos from Mn exposure, suggesting a compensatory role for Atp2c1 in the ..
  52. Edalat L, Stegen B, Klumpp L, Haehl E, Schilbach K, Lukowski R, et al. BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells. Oncotarget. 2016;7:14259-78 pubmed publisher
    Infiltration of the brain by glioblastoma cells reportedly requires Ca2+ signals and BK K+ channels that program and drive glioblastoma cell migration, respectively...
  53. Vince J, Reithmeier R. Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger. J Biol Chem. 1998;273:28430-7 pubmed
    ..carboxyl-terminal (Ct) region of the human erythrocyte chloride/bicarbonate exchanger, band 3, binds carbonic anhydrase II (CAII)...
  54. Howard A, Legon S, Walters J. Human and rat intestinal plasma membrane calcium pump isoforms. Am J Physiol. 1993;265:G917-25 pubmed
    ..membrane Ca(2+)-transporting adenosinetriphosphatase is the energy-dependent step in the absorption of dietary Ca2+ by the vitamin D-dependent transcellular pathway...
  55. An J, Bosnjak Z, Jiang M. Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels. Anesth Analg. 2007;105:1207-13, table of contents pubmed
    ..Mitochondrial and sarcolemmal K(ATP) channel openings have been implicated in APC-induced cardioprotection. In this study, we investigated the effect of APC on major calcium cycling proteins and its relation to K(ATP) channels...
  56. Diez R, Richardson M, Wall M. Reducing Extracellular Ca2+ Induces Adenosine Release via Equilibrative Nucleoside Transporters to Provide Negative Feedback Control of Activity in the Hippocampus. Front Neural Circuits. 2017;11:75 pubmed publisher
    ..We propose that sustained action potential firing following Ca2+ removal leads to hydrolysis of ATP and a build-up of intracellular adenosine which then effluxes into the extracellular space via ENTs...
  57. Luongo T, Lambert J, Gross P, Nwokedi M, Lombardi A, Shanmughapriya S, et al. The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature. 2017;545:93-97 pubmed publisher
    ..These results demonstrate the essential nature of mCa2+ efflux in cellular function and suggest that augmenting mCa2+ efflux may be a viable therapeutic strategy in disease. ..
  58. Hisamatsu Y, Suzuki N, Masum A, Shibuya A, Abe R, Sato A, et al. Cationic Amphiphilic Tris-Cyclometalated Iridium(III) Complexes Induce Cancer Cell Death via Interaction with Ca2+-Calmodulin Complex. Bioconjug Chem. 2017;28:507-523 pubmed publisher
    ..A plausible mechanism for cell death induced by a cationic amphiphilic Ir complex is discussed on the basis of our results...
  59. Kilpatrick B, Eden E, Hockey L, Yates E, Futter C, Patel S. An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling. Cell Rep. 2017;18:1636-1645 pubmed publisher
    ..Membrane contact sites between endosomes and the ER thus emerge as Ca2+-dependent hubs for signaling. ..
  60. Kshatri A, Gonzalez Hernandez A, Giraldez T. Functional validation of Ca2+-binding residues from the crystal structure of the BK ion channel. Biochim Biophys Acta. 2017;: pubmed publisher
    ..This article is part of a Special Issue entitled: Beyond the Structure-Function Horizon of Membrane Proteins edited by Ute Hellmich, Rupak Doshi and Benjamin McIlwain...
  61. Reboud E, Bouillot S, Patot S, Béganton B, Attree I, Huber P. Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation. PLoS Pathog. 2017;13:e1006579 pubmed publisher
    ..ADAM10 activation is controlled in the host cell by cytosolic Ca2+ concentration...
  62. Norante R, Massimino M, Lorenzon P, De Mario A, Peggion C, Vicario M, et al. Generation and validation of novel adeno-associated viral vectors for the analysis of Ca2+ homeostasis in motor neurons. Sci Rep. 2017;7:6521 pubmed publisher
    ....