Genomes and Genes
Gene Symbol: CACNA1C
Description: calcium voltage-gated channel subunit alpha1 C
Alias: CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, voltage-dependent L-type calcium channel subunit alpha-1C, DHPR, alpha-1 subunit, calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit, calcium channel, voltage-dependent, L type, alpha 1C subunit, voltage-dependent L-type Ca2+ channel alpha 1 subunit, voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
Publications241 found, 100 shown here
- Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivationFelix Findeisen
Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2330, USA
Structure 18:1617-31. 2010..Discovery of this division provides the framework for understanding how CaBP1 regulates Ca(V)s...
- Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1Hong Zhou
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 280:29612-9. 2005..We conclude that the NT and IQ-domains of alpha(1)1.2 mediate functionally distinct interactions with CaBP1 and CaM that promote conformational alterations that either stabilize or inhibit inactivation of Ca(v)1.2...
- Hallmarks of the channelopathies associated with L-type calcium channels: a focus on the Timothy mutations in Ca(v)1.2 channelsIsabelle Bidaud
CNRS, UMR 5203, Institut de Genomique Fonctionnelle, Montpellier, France
Biochimie 93:2080-6. 2011..Among them, the Timothy syndrome (TS) is linked to missense mutations in CACNA1C, the gene that encodes the Ca(v)1.2 subunit. Here we review the important features of the Cav1 channelopathies...
- Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channelsHong Zhou
Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 24:4698-708. 2004..2 with these same voltage protocols. Our findings reveal how Ca2+-binding proteins, such as CaM and CaBP1, differentially adjust Ca2+ influx through Ca(v)1.2 channels, which may specify diverse modes of Ca2+ signaling in neurons...
- alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulationGreg L Lyford
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Physiol Cell Physiol 283:C1001-8. 2002..These data demonstrate mechanical regulation of calcium entry through molecularly identified L-type calcium channels in mammalian cells and suggest that the mechanosensitivity resides within the pore forming alpha(1C)-subunit...
- Mapping of dihydropyridine binding residues in a less sensitive invertebrate L-type calcium channel (LCa v 1)Adriano Senatore
Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
Channels (Austin) 5:173-87. 2011..2. Interestingly, the single N_3o18_Q mutation in LCa(v) 1 channels lowers DHP sensitivity even further and the triple mutation bearing enhanced isradipine sensitivity, still retains a reduced potency of agonist, (S)-Bay K8644...
- Ca(v)1.2 splice variant with exon 9* is critical for regulation of cerebral artery diameterMatthew A Nystoriak
Department of Pharmacology and Surgery, University of Vermont, College of Medicine, Burlington, VT 05405 0068, USA
Am J Physiol Heart Circ Physiol 297:H1820-8. 2009..We conclude that although cerebral artery myocytes express both alpha(1)C(9/9*/10) and alpha(1)C(9/10) VDCC splice variants, alpha(1)C(9/9*/10) is functionally dominant in the control of cerebral artery diameter...
- Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channelA E Lacerda
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
Nature 352:527-30. 1991....
- Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heartD Schultz
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267 0575
Proc Natl Acad Sci U S A 90:6228-32. 1993..The cloned alpha 1 subunit was expressed in Xenopus oocytes and single-channel analyses revealed native-like pharmacology and channel properties...
- Tissue-specific expression of two human Ca(v)1.2 isoforms under the control of distinct 5' flanking regulatory elementsLi Pang
Department of Medicine, Montreal Heart Institute, and University of Montreal, 5000 Belanger St East, Montreal, QC, Canada H1T 1C8
FEBS Lett 546:349-54. 2003..These data indicate specific expression patterns of two human Ca(v)1.2 isoforms under the control of distinct 5' flanking regulatory sequences...
- Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currentsXianming Wang
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Biophys J 89:1731-43. 2005..In summary, the physicochemical properties of the amino acid residues at positions 1144 and 1152 are crucial to the pore's ability to distinguish between multiple Ba(2+) ions and Ca(2+) ions...
- Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulationHannelore Haase
Max Delbrück Center for Molecular Medicine MDC, D 13092 Berlin, Germany
FASEB J 19:1969-77. 2005..This genetic ahnak variant might cause individual differences in I(CaL) regulation upon physiological challenges or therapeutic interventions...
- Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channelJennifer L Fallon
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Structure 13:1881-6. 2005..These findings suggest that this structure could represent the conformation that calmodulin assumes in CDF...
- Calmodulin-dependent gating of Ca(v)1.2 calcium channels in the absence of Ca(v)beta subunitsArippa Ravindran
National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 105:8154-9. 2008..We suggest that CaM(ex) affects specific Ca(v)beta-free conformations of the channel that are not available to endogenous CaM...
- The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid raftsSarah Melissa P Jacobo
Program in Biochemistry and Molecular Biology, Purdue University, West Lafayette, Indiana, USA
J Pharmacol Exp Ther 330:283-93. 2009..These findings suggest that the II-III interdomain loops of Ca(v)1.2, and possibly Ca(v)1.3, direct these channels to membrane microdomains in which the proteins that mediate potentiation of GSIS by GLP-1 and 8-Br-cAMP assemble...
- Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domainFilip Van Petegem
Cardiovascular Research Institute, Department of Biochemistry and Biophysics, University of California San Francisco, 513 Parnassus Avenue, Box 0130, San Francisco, California 94143, USA
Nature 429:671-5. 2004..Together, these data suggest that Ca(V)betas influence Ca(V) gating by direct modulation of IS6 movement within the channel pore...
- Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channelsYu hang Chen
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Nature 429:675-80. 2004..The presence of multiple protein-interacting modules in the beta-subunit opens a new dimension to its function as a multi-functional protein...
- Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunitZhen Zhi Tang
Department of Physiology, National University of Singapore, Singapore 117597
J Biol Chem 279:44335-43. 2004..This systematic portrait of splice variation furnishes a reference library for comprehending combinatorial arrangements of Cav1.2 splice exons, especially as they impact development, physiology, and disease...
- Severe arrhythmia disorder caused by cardiac L-type calcium channel mutationsIgor Splawski
Howard Hughes Medical Institute, Department of Cardiology, and Genomics Program and Division of Genetics, Children s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:8089-96; discussion 8086-8. 2005..These data indicate that gain-of-function mutations of CaV1.2 exons 8 and 8A cause distinct forms of TS...
- International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channelsWilliam A Catterall
Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
Pharmacol Rev 57:411-25. 2005..This article presents the molecular relationships and physiological functions of these calcium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties...
- CACNA1C polymorphisms are associated with the efficacy of calcium channel blockers in the treatment of hypertensionTroy Bremer
Prediction Sciences, 9404 Genesee Ave, Suite 210, La Jolla, CA 92037, USA
Pharmacogenomics 7:271-9. 2006..of 62 single nucleotide polymorphisms (SNPs) in the calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) gene were obtained for each subject from a blood sample...
- L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of currentShawn M Crump
Dept of Physiology, MS 508, Univ of Kentucky College of Medicine, 800 Rose St Lexington, KY 40536 0298, USA
Am J Physiol Heart Circ Physiol 291:H1959-71. 2006..We conclude that Rem is capable of regulating L-type current, that release of Rem block is modulated by cellular kinase pathways, and that the Ca(V)1.2 COOH terminus contributes to Rem-dependent channel inhibition...
- The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channelsCurtis F Barrett
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5345, USA
Proc Natl Acad Sci U S A 105:2157-62. 2008..Thus, the TS mutation offers a unique perspective on mechanisms of inactivation as well as a promising starting point for exploring the underlying pathophysiology of autism...
- Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..indicates concordant signals for SNPs within the voltage-dependent calcium channel, L-type, alpha 1C subunit (CACNA1C) gene...
- Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorderManuel A R Ferreira
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Genet 40:1056-8. 2008..1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737)...
- Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockersKei Kamide
Division of Hypertension and Nephrology, Research Institute, National Cardiovascular Center, Suita, Japan
Circ J 73:732-40. 2009..The response of blood pressure (BP) to L-type dihydropyridine calcium-channel blockers (dCCBs) differs among individuals...
- Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2Michaela Kudrnac
Department of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A 1090 Wien, Austria
J Biol Chem 284:12276-84. 2009..8 +/- 1.4 mV). Mutant cycle analysis revealed energetic coupling between residues Ser-435 and Ile-781, whereas other paired mutations in segments IS6 and IIS6 had independent effects on activation gating...
- The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophreniaE K Green
Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 15:1016-22. 2010..Strong evidence (P=7.0 × 10(-7)) of association at the polymorphism rs1006737 (within CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar ..
- Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individualsAxel Krug
Department of Psychiatry, Philipps University Marburg, Rudolf Bultmann Str 8, 35039 Marburg, Germany
Neuroimage 49:1831-6. 2010..found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression...
- CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiencyPing Liao
National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore
Pflugers Arch 460:353-9. 2010..Here, we will discuss how alternative splicing modulates CaV1.2 channelopathy and the role of CaV1.2 channel in both excitable and non-excitable tissues...
- Brain function in carriers of a genome-wide supported bipolar disorder variantSusanne Erk
Division of Medical Psychology, University of Bonn, Bonn, Germany
Arch Gen Psychiatry 67:803-11. 2010..through genome-wide association, of a single-nucleotide polymorphism (rs1006737) strongly associated with bipolar disorder within the CACNA1C gene, encoding the alpha subunit of the L-type voltage-dependent calcium channel Ca(v)1.2.
- Genetic variation in CACNA1C affects brain circuitries related to mental illnessKristin L Bigos
Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:939-45. 2010The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored.
- Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learnedN R Wray
Genetic Epidemiology, Molecular Epidemiology, Psychiatric Genetics and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, QLD, Australia
Mol Psychiatry 17:36-48. 2012..of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1...
- Effects of a CACNA1C genotype on attention networks in healthy individualsM Thimm
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Germany
Psychol Med 41:1551-61. 2011..found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major ..
- Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorderE Perrier
Medizinische Fakultat, Universitat zu Koln, Germany
Eur Psychiatry 26:135-7. 2011The polymorphism rs1006737 within the CACNA1C gene is associated with increased risk for bipolar disorder (BD) and variations in brain morphology and function of subcortical regions...
- Robust L-type calcium current expression following heterozygous knockout of the Cav1.2 gene in adult mouse heartBarbara Rosati
Department of Physiology and Biophysics, BST Room 124, Level 6, Stony Brook University, Stony Brook, NY 11794 8661, USA
J Physiol 589:3275-88. 2011..The results are consistent with a model of L-type calcium channel biosynthesis in which there are one or more saturated steps, which act to buffer changes in both total Cav1.2 protein and L-type current expression...
- The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy malesPanos Roussos
Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
Bipolar Disord 13:250-9. 2011The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with ..
- Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 proteinKatrin Depil
Department of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
J Biol Chem 286:31557-64. 2011..2 in the closed state. Such a structural hypothesis is supported by changes in activation gating induced by mutations of the G/A/G/A residues. The structural implications for Ca(V)1.2 activation and inactivation gating are discussed...
- ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotypeTristram A P Lett
Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
World J Biol Psychiatry 12:392-7. 2011OBJECTIVES. The ANK3, CACNA1C and ZNF804A genes have been implicated in both bipolar disorders (BPD) and schizophrenia (SCZ)...
- The effects of CACNA1C gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorderQiumei Zhang
School of Mental Health, Jining Medical University, Jining, China
Neuropsychopharmacology 37:677-84. 2012b>CACNA1C gene polymorphism (rs1006737) is a susceptibility factor for both schizophrenia (SCZ) and bipolar disorder (BP). However, its role in working memory, a cognitive function that is impaired in both diseases, is not clear...
- ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samplesStefan Kloiber
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
J Psychiatr Res 46:973-9. 2012..genome-wide association studies (GWAS) and metaanalyses revealed genetic associations for ANK3 (ankyrin 3) and CACNA1C (alpha 1C subunit of the L-type voltage gated calcium channel) with bipolar disorder (BPD)...
- CACNA1C (Cav1.2) in the pathophysiology of psychiatric diseaseShambhu Bhat
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
Prog Neurobiol 99:1-14. 2012..consistent genetic findings to have emerged from bipolar disorder genome wide association studies (GWAS) is with CACNA1C, a gene that codes for the α(1C) subunit of the Ca(v)1.2 voltage-dependent L-type calcium channel (LTCC)...
- Exome sequencing and systems biology converge to identify novel mutations in the L-type calcium channel, CACNA1C, linked to autosomal dominant long QT syndromeNicole J Boczek
Center for Translational Science Activities, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
Circ Cardiovasc Genet 6:279-89. 2013..Long QT syndrome (LQTS) is the most common cardiac channelopathy with 15 elucidated LQTS-susceptibility genes. Approximately 20% of LQTS cases remain genetically elusive...
- Molecular diversity of L-type Ca2+ channel transcripts in human fibroblastsN M Soldatov
Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021 6399
Proc Natl Acad Sci U S A 89:4628-32. 1992..The fourth diversity region is located at the C-terminal region and comprises insertions and deletions. It is suggested that these variations may give rise to multiple subforms of HFCC with altered electrophysiological properties...
- Genomic structure of human L-type Ca2+ channelN M Soldatov
Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021 6399
Genomics 22:77-87. 1994..The cDNA for the human fibroblast Ca2+ channel (CACNL1A1) was previously characterized...
- A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunitT Perets
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
FEBS Lett 384:189-92. 1996..This effect was independent of the presence of the beta subunit. Phosphorylation of serine 1928 of alpha 1C may mediate the modulatory effect of PKA on the cardiac voltage-dependent ca2+ channel...
- Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit geneR D Zühlke
Department of Pharmacology, University of Bern, Switzerland
FEBS Lett 427:220-4. 1998..Among seven alpha1C channels we observed up to 10-fold differences in IC50 values for isradipine, as well as changes in the voltage dependence of DHP action...
- Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autismIgor Splawski
Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
Cell 119:19-31. 2004..These discoveries establish the importance of Ca(V)1.2 in human physiology and development and implicate Ca(2+) signaling in autism...
- Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ionsEvgeny Kobrinsky
Laboratory of Clinical Investigation, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
J Biol Chem 280:12474-85. 2005..Thus, cross-talk between the alpha1C C and N termini, beta subunit, and the cytoplasmic pore region confers the multifactorial regulation of Ca(v)1.2 channels...
- Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorderAnnette Hohaus
Institute for Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A 1090 Wien
J Biol Chem 280:38471-7. 2005..2. These four residues are completely conserved in high voltage-activated calcium channels suggesting that these channels may share a common mechanism of gating...
- Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in miceJessica A White
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0069, USA
Learn Mem 15:1-5. 2008..2(cKO) mice exhibited significant impairments in spatial memory when examined 30 d after training, suggesting that Ca(V)1.2 plays a critical role in consolidation of remote spatial memories...
- Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca V 1.2Anna Stary
Institute for Theoretical Chemistry, University of Vienna, Vienna, Austria
Channels (Austin) 2:216-23. 2008..2 gating. Our study illustrates that effects of mutations in the lower part of IIS6 may not be localized to the residue or even segment being mutated, but may affect conformations of interacting segments...
- Phenotypic effects of a bipolar liability gene among individuals with major depressive disorderFrancesco Casamassima
Division of Psychiatry, University of Pisa, Pisa, Italy
Am J Med Genet B Neuropsychiatr Genet 153:303-9. 2010Variations in voltage-dependent calcium channel L-type, alpha 1C subunit (CACNA1C) gene have been associated with bipolar disorder in a recent meta-analysis of genome-wide association studies [Ferreira et al., 2008]...
- Different pathways for activation and deactivation in CaV1.2: a minimal gating modelStanislav Beyl
Department of Pharmacology and Toxicology, University of Vienna, 1090 Vienna, Austria
J Gen Physiol 134:231-41; S1-2. 2009..We speculate that structural changes induced by a proline substitution in this position may disturb the voltage-sensing domain...
- Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individualsBarbara Franke
Department of Human Genetics, Institute for Genetic and Metabolic Disorders, Center for Neuroscience, Radboud University Nijmegen Medical Center, The Netherlands
Biol Psychiatry 68:586-8. 2010Genetic variation in CACNA1C has been repeatedly shown to increase risk for psychiatric disorders, with the strongest evidence for involvement in bipolar disorder...
- Physicochemical properties of pore residues predict activation gating of Ca V1.2: a correlation mutation analysisStanislav Beyl
Institute for Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, Vienna, Austria
Pflugers Arch 461:53-63. 2011..The identified physicochemical properties in the analysed gating-sensitive positions (accessible surface area, side-chain flexibility, and hydrophobicity) predict the shifts of the activation curves of Ca(V)1.2...
- The association of genetic variation in CACNA1C with structure and function of a frontotemporal systemFei Wang
Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA
Bipolar Disord 13:696-700. 2011A single nucleotide polymorphism at the CACNA1C gene (rs1006737) has been reported in genome-wide association studies to be associated with bipolar disorder (BD) with genome-wide significance...
- A new promoter for alpha1C subunit of human L-type cardiac calcium channel Ca(V)1.2Bosong Dai
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555 0641, USA
Biochem Biophys Res Commun 296:429-33. 2002..The putative promoter exhibits 69% homology to its rat counterpart and displays functional promoter activity when transfected into heart cells in culture in luciferase-expressing constructs...
- Tissue distribution of a human Ca v 1.2 alpha1 subunit splice variant with a 75 bp insertionEva M Graf
Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der TU Dresden, Fetscherstr 74, D 01307 Dresden, Germany
Cell Calcium 38:11-21. 2005..We conclude that the +9* variant is present in all human tissues investigated so far, and suggest that expression in human atrium is associated with vascular smooth muscle and/or connective tissue cells...
- Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockersK Mills
Department of Pharmacology, Meharry Medical College, Nashville, TN 37208, USA
Life Sci 81:600-8. 2007..Flunarizine and diltiazem attenuated the behavioral response by decreasing calcium uptake and decreasing neurochemical release...
- L-type calcium channels and psychiatric disorders: A brief reviewFrancesco Casamassima
Division of Psychiatry, University of Pisa, Pisa, Italy
Am J Med Genet B Neuropsychiatr Genet 153:1373-90. 2010..the association of polymorphisms in the alpha 1C subunit of the L-type voltage-gated calcium channel gene (CACNA1C) with bipolar disorder...
- Gating of the HypoPP-1 mutations: II. Effects of a calcium-channel agonist BayK 8644Alexey Kuzmenkin
Department of Applied Physiology, University of Ulm, 89069 Ulm, Germany
Pflugers Arch 454:605-14. 2007....
- The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genesY Yamada
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan
Genomics 27:312-9. 1995..by introns are well conserved between the CACNL1A2 gene and the previously reported L-type VDCC alpha 1 subunit, CACNL1A1, gene...
- Multiple loops of the dihydropyridine receptor pore subunit are required for full-scale excitation-contraction coupling in skeletal muscleLeah Carbonneau
Department of Physiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
Biophys J 89:243-55. 2005..Thus, despite the importance of the II-III loop there may be other critical determinants in alpha1S that influence the efficiency of EC coupling...
- Differential splicing patterns of L-type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto RatsZhen Zhi Tang
Department of Physiology, National University of Singapore, Singapore 117597
Biochim Biophys Acta 1783:118-30. 2008..2 transcripts identified in SHR hearts provide a different and new perspective in understanding the possible role of molecular remodeling of Cav1.2 channels in cardiac hypertrophy as a consequence of hypertension...
- [Altered expression of L-type calcium channel alpha1C and alpha1D subunits in colon of rats with diarrhea-predominant irritable bowel syndrome]Jie Zhu
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Zhonghua Yi Xue Za Zhi 89:2713-7. 2009..To investigate the molecular identities of L-type calcium channel alpha1C subunit (Cav1.2) and alpha1D subunit (Cav1.3) responsible for motor dysfunction of diarrhea-predominant irritable bowel syndrome (D-IBS)...
- Insulin-like growth factor-1 increases skeletal muscle dihydropyridine receptor alpha 1S transcriptional activity by acting on the cAMP-response element-binding protein element of the promoter regionZhenlin Zheng
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Biol Chem 277:50535-42. 2002..These results support the conclusion that IGF-1 regulates DHPR alpha(1S) transcription in muscle cells by acting on the CREB element of the promoter...
- Cardiac L-type calcium channel beta-subunits expressed in human heart have differential effects on single channel characteristicsRoger Hullin
Cardiology, Swiss Cardiovascular Heart Center Bern, University Hospital, 3010 Bern, Switzerland
J Biol Chem 278:21623-30. 2003..Moreover, differences in the various beta-subunit gene products present in human heart might account for altered single channel behavior found in human heart failure...
- Differential modulation of L-type calcium channel subunits by oleateYingrao Tian
Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, VA, USA
Am J Physiol Endocrinol Metab 294:E1178-86. 2008..3 and Cav1.2) appear to be targeted by nonesterified fatty acids. This effect may account in part for the acute potentiation of glucose-dependent insulin secretion by fatty acids...
- CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylationSunday A Abiria
Brain Institute, Vanderbilt University, Nashville, Tennessee, USA
J Neurochem 112:150-61. 2010..2alpha(1) and beta subunits. These findings demonstrate a biochemical mechanism underlying LTCC facilitation by CaMKII...
- L-type calcium channels in adrenal chromaffin cells: role in pace-making and secretionA Marcantoni
Department of Neuroscience, NIS Center of Excellence, CNISM Research Unit, Corso Raffaello 30, 10125 Torino, Italy
Cell Calcium 42:397-408. 2007..Here we will review all these novel findings and discuss the possible implication for a specific role of L-type channels in the control of chromaffin cells activity...
- Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heartSabine Link
Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat des Saarlandes, 66421 Homburg, Germany
J Biol Chem 284:30129-37. 2009....
- Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticityLi Yang
Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 29:15660-8. 2009..2. These results provide a direct link between APP and calcium signaling and might help explain how altered APP regulation leads to changes in synaptic function that occur with AD...
- GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomasDo Young Kim
Division of Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Epilepsia 49:861-71. 2008..Here, we examined the role of GABAA receptors in surgically resected HH tissue...
- A common single nucleotide polymorphism can exacerbate long-QT type 2 syndrome leading to sudden infant deathEyal Nof
Masonic Medical Research Laboratory, Utica, NY 13501, USA
Circ Cardiovasc Genet 3:199-206. 2010..We present a family in which a common polymorphism (single nucleotide polymorphism) inherited from the father, combined with a stop codon mutation inherited from the mother (both asymptomatic), led to 2 cases of sudden infant death...
- Role of the synprint site in presynaptic targeting of the calcium channel CaV2.2 in hippocampal neuronsZsolt Szabo
Department of Physiology and Medical Physics, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
Eur J Neurosci 24:709-18. 2006..The unique targeting properties of the splice variants lacking the synprint site are suggestive of specific functions of these calcium channels apart from activating fast synaptic transmission...
- Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulusSumangali Wijetunge
Clinical Pharmacology, NHLI Division, Faculty of Medicine, Imperial College London, London, UK
J Hypertens 25:1871-8. 2007..2). We studied possible roles of tyrosine kinases, particularly src family kinases (SFK) and extracellular signal-related kinases (ERK1/2), in this response...
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11K J Oedegaard
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
J Affect Disord 122:14-26. 2010..regions of linkage on chromosomes, and two functionally similar voltage-dependent calcium channels CACNA1A and CACNA1C have been identified in familial hemiplegic migraine and recently implicated in two whole genome BPAD association ..
- Effects of extracellular pH on neuronal calcium channel activationC J Doering
Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
Neuroscience 146:1032-43. 2007....
- Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2Sven Moosmang
Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
Circ Res 98:105-10. 2006..2SMAKO mice. These results demonstrate that the effect of the putative T-type Ca2+ channel-selective blocker mibefradil on blood pressure and small vessel myogenic tone is mediated by the Cav1.2 L-type Ca2+ channel...
- Altered localization of Cav1.2 (L-type) calcium channels in nerve fibers, Schwann cells, odontoblasts, and fibroblasts of tooth pulp after tooth injuryR E Westenbroek
Department of Pharmacology, University of Washington, Seattle, USA
J Neurosci Res 75:371-83. 2004..These findings provide new insight into the localization of Cav1.2 channels in dental pulp and sensory fibers, and demonstrate unexpected plasticity of channel distribution in response to nerve injury...
- Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1Rao V L Papineni
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 277:49167-74. 2002....
- The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type)Roy Cohen
Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
J Biol Chem 278:9258-66. 2003..It indicates that calcium-independent properties of Syt 1 regulate voltage-gated Ca2+ channels and contribute to the molecular events underlying transmitter release...
- Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heartNathalie Gaborit
INSERM U533, Nantes, France
J Physiol 582:675-93. 2007..Concordance with previous functional studies suggests that regional regulation of cardiac ion-current expression may be primarily transcriptional...
- Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmiasNagesh Chopra
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 106:7636-41. 2009....
- Phosphate and calcium are required for TGFbeta-mediated stimulation of ANK expression and function during chondrogenesisPaulina Oca
Center for Translational Medicine, Department Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Cell Physiol 224:540-8. 2010..Our findings indicate that TGFbeta stimulation of ANK expression is dependent upon the influx of phosphate and calcium into ATDC5 cells at all stages of differentiation...
- Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding proteinZhen Zhi Tang
Howard Hughes Medical Institute, UCLA, Los Angeles, California 90095, USA
J Biol Chem 286:10007-16. 2011..The nPTB protein is a weaker repressor of exon 8a, resulting in a shift in exon choice when nPTB replaces PTB in cells. These results provide mechanistic understanding of how these two exons, important for human disease, are controlled...
- PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2Kamala K Maddali
Department of Biomedical Sciences, Dalton Cardiovascular Research Center, National Center for Gender Physiology, University of Missouri, Columbia, Missouri 65211, USA
J Biol Chem 280:43024-9. 2005..These results demonstrate for the first time that 1) endogenous T is a primary modulator of coronary PKCdelta protein and activity in males and 2) T increases Cav1.2 protein expression in a PKCdelta-dependent manner...
- Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cellsAndrea Marcantoni
Department of Neuroscience, Nanostructured Interfaces and Surfaces Centre of Excellence, Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, 10125 Torino, Italy
J Neurosci 30:491-504. 2010..2, as subthreshold pacemaker channels in MCCs and open new interesting features about their role in the control of firing and catecholamine secretion at rest and during sustained stimulations matching acute stress...
- Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertensionKatrin Wenzel
Medical Faculty of the Charite, Franz Volhard Clinic and HELIOS Klinikum Berlin, Experimental and Clinical Research Center, Berlin, Germany
PLoS ONE 3:e3742. 2008..We implied earlier that alpha(1)-AAB might have a mechanistic role and could represent a therapeutic target...
- Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndromeYung Hsin Yeh
Department of Medicine, Montreal Heart Institute Research Center and Université de Montréal, Montreal, Quebec, Canada
Circulation 119:1576-85. 2009..This study examined the hypothesis that ATs impair SAN function by altering ion channel expression...
- The genetics of bipolar disorderJ H Barnett
Center for Human Genetic Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Neuroscience 164:331-43. 2009..genes for a variety of complex disorders, has begun to implicate specific genes for bipolar disorder (DGKH, CACNA1C, ANK3)...
- Expression of recombinant calcium channels support secretion in a mouse pheochromocytoma cell lineAmy B Harkins
Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
J Neurophysiol 90:2325-33. 2003..This model may help to distinguish the roles that different Ca2+ channels play in Ca2+-dependent secretion...
- Cav1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cellsLubica Lacinova
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava, Slovakia
Life Sci 82:41-9. 2008..2 channels are involved in regulating the intrinsic excitability of CA1 pyramidal neurons. This cellular mechanism may contribute to the known function of Ca(v)1.2 channels in supporting synaptic plasticity and memory...
- Congenital long QT syndromeLia Crotti
Section of Cardiology, Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy
Orphanet J Rare Dis 3:18. 2008..Mutations in these genes (KCNQ1, KCNH2, KCNE1, KCNE2, CACNA1c, CAV3, SCN5A, SCN4B) cause the disease by prolonging the duration of the action potential...
- Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndromeJonathan M Cordeiro
Department of Experimental Cardiology, Masonic Medical Research Laboratory, Utica, NY 13501, USA
J Mol Cell Cardiol 46:695-703. 2009Recent studies have demonstrated an association between mutations in CACNA1c or CACNB2b and Brugada syndrome (BrS). Previously described mutations all caused a loss of function secondary to a reduction of peak calcium current (I(Ca))...
- Cell Cycle-Dependent Localization of Voltage-Dependent Calcium Channels and the Mitotic Apparatus in a Neuroendocrine Cell Line(AtT-20)Karen J Loechner
Division of Pediatric Endocrinology, Department of Pediatrics, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Int J Cell Biol 2009:487959. 2009....
- Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2Yong Fu Xiao
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Mol Pharmacol 66:1607-16. 2004..In conclusion, overexpression of CYP2J2 increases ICa in CYP2J2 transgenic cardiomyocytes via a mechanism that involves cAMP-protein kinase A-dependent phosphorylation of the L-type Ca2+ channel...
- Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human NeuronsJEN PAN; Fiscal Year: 2013..Calcium ion channels are important drug targets for hypertension and neuropathic pain. Coding mutations in the CACNA1C calcium ion channel gene cause a rare hereditary disorder called Timothy Syndrome, affecting the heart, the brain,..
- Gonadal Hormones and Depression:The Role of Mood Disorder Risk Gene CACNA1CTodd D Gould; Fiscal Year: 2012..Numerous recent human genetic studies indicate a robust association between polymorphisms in CACNA1C, a gene that codes for the 11 subunit of the CaV1...
- Neuronal-Specific Splicing of CaV1.2 L-type Calcium ChannelsKristin Webster; Fiscal Year: 2013..I hypothesize that the e1b isoform will more efficiently induce CREB phosphorylation. These experiments will advance our understanding of how neuronal specific isoforms of CaV1.2 contribute to essential neuronal functions. ..
- Chemokine receptor-4 regulation of Beta adrenergic-mediated calcium channelSima T Tarzami; Fiscal Year: 2012....
- SHAWN BRADY BENDER; Fiscal Year: 2016..IR will be induced in wild-type and VSMC MR KO mice with a high-fat, high-sucrose diet and will be assessed by glucose tolerance testing. ..
- Single nucleotide polymorphisms of neuronal CACNA1C L-type calcium channels assocDiane Lipscombe; Fiscal Year: 2011..Calcium ion channels are important drug targets for treating hypertension and neuropathic pain. Mutations in the CACNA1C calcium ion channel gene cause a rare hereditary disorder Timothy Syndrome and single nucleotide polymorphisms ..
- Chronic stress-induced gene expression in colonic circular smooth muscle cells.Sushil K Sarna; Fiscal Year: 2012..The findings of this proposal are expected to identify the potential molecular therapeutic approaches that may prevent or minimize the ill effects of chronic stress on colonic motility function. ..
- AKAP Regulation of Neuronal L-type Calcium Channel Signaling to the NucleusMARK L DELL'ACQUA; Fiscal Year: 2013....
- Regulation of Cardiac Gene Expression by the L-type Calcium Channel, CaV1.2.ROBERT NATHAN CORRELL; Fiscal Year: 2011..This work will help reveal the role of the cardiac L-type Ca2+ channel in regulation of gene expression related to disease and may suggest new translational strategies to combat heart failure. ..
- Secretagogue induced mechanisms regulating islet electrical activityDAVID AARON JACOBSON; Fiscal Year: 2012..Understanding how secretagogues regulate islet electrical activity distinctly from KATP may help to develop new therapies that target specific elements of the excitation-secretion pathway. ..
- L-type Ca2+ Channel Modulation of Beta Cell FunctionGREGORY HOWARD HOCKERMAN; Fiscal Year: 2012..This proposal is consistent with the PI's long term goal of understanding L-type calcium channel modulation and cellular function. ..
- Luis F Santana; Fiscal Year: 2016..2 channel that causes arrhythmias and autism in humans with long QT syndrome 8 (LQT8)...
- Fibroblast Growth Factor Homologous Factors: Modulation of L-type Calcium ChannelJESSICA AMENTA HENNESSEY; Fiscal Year: 2013..This will demonstrate that FGF13 is a prominent player in the cardiac action potential through its modulation of the LTCC and define FGF13 dysfunction as a mediator of acquired and inherited arrhythmias. ..
- L-type Calcium Channel Regulation of Neuronal DifferentiationGeorgia Panagiotakos; Fiscal Year: 2012..These studies will expand our understanding of how activity regulates brain development and will provide new insights into the underlying pathophysiology of autism and mental retardation. ..
- Masayuki Yazawa; Fiscal Year: 2015..abstract_text> ..
- Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem CellsMasayuki Yazawa; Fiscal Year: 2013..The proposed systems to screen a library of compounds to rescue TS phenotypes will provide a platform to find novel lead compounds that would be clinically useful for the treatment of not only TS but also other cardiac arrhythmias. ..
- The Role of Calcium Signaling in Stem Cell QuiescenceGozde Yucel; Fiscal Year: 2010..Consistent with this finding, conditional ablation of CACNA1C (CaVI ...
- MicroRNA to decrease vascular CaV1.2 in hypertensionPhilip T Palade; Fiscal Year: 2013..A longer lasting therapy with fewer side effects may be extremely beneficial for the >40 million Americans whose hypertension is not properly managed. ..
- Reciprocal Control of Ca2+ Channels by Anchored Protein Kinase A and CalcineurinWilliam A Sather; Fiscal Year: 2010..A mutation in the calcium channel studied here has been identified as the cause of Timothy syndrome in humans, symptoms of which are cognitive impairment and potentially fatal disturbance of heart rhythm. ..
- OLIVIA RUTH BUONARATI; Fiscal Year: 2015..2-associated disorders in the central nervous system, including stroke, depression, anxiety, senility and Alzheimer's disease. ..
- William A Catterall; Fiscal Year: 2016..These studies will increase understanding of regulation of the heart by the sympathetic nervous system and give essential new insight into the molecular and functional changes in the Cav1.2 signaling complex in heart failure. ..
- Calcium channels in arterial smooth muscle cellsJonathan H Jaggar; Fiscal Year: 2013..2 channels are expressed in arterial smooth muscle cells, and that the molecular composition of these channels is altered in hypertension, leading to vasoconstriction. ..
- Regulation of Calcium Channel Function by the Rem GTPaseJonathan Satin; Fiscal Year: 2013....
- PABLO MARTIN PAEZ; Fiscal Year: 2016..These findings could lead to novel approaches to intervene in neurodegenerative diseases in which myelin is lost or damaged. ..
- Myocardial Properties of Timothy SyndromeRANDALL RASMUSSON; Fiscal Year: 2009..Patients with Timothy Syndrome die at an average age of 2.5 years. In order to better understand and treat this disorder we will study a mouse in which the same genetic defect has been artificially introduced. ..
- Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using Induced PluriJOACHIM F contact HALLMAYER; Fiscal Year: 2010..iPS cells from human fibroblasts harvested from healthy controls and ASD patients with mutations in the CACNA1C and SHANK3 gene, mutations known to affect neuronal development, and optimize and characterize the ..
- Central Synaptic Transmission in Drosophila.DIANE O DOWD; Fiscal Year: 2009..Thus knowledge of the cellular mechanisms contributing to the behavioral deficits in cac mutant flies should also contribute to understanding of human diseases associated with mutant calcium channel genes. ..
- Cav1.2 Transcript Regulation in Heart and Smooth MusclePhilip Palade; Fiscal Year: 2007..They could suggest new targets for pharmaceutical intervention in disorders involving alterations in expression of L-type Ca channels, such as hypertension. [unreadable] [unreadable] [unreadable]..
- Store operated calcium influx in cells of the immune systemJEAN PIERRE M KINET; Fiscal Year: 2012..2 (Aim 2) and CaV1.3 (Aim 3) interact and modulate CRAC channels. These studies will yield new insights into the molecular regulation of SOCE within T cells, enabling the development new approaches to treat autoimmune diseases. ..
- Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using Induced PluriJoachim F Hallmayer; Fiscal Year: 2013..iPS cells from human fibroblasts harvested from healthy controls and ASD patients with mutations in the CACNA1C and SHANK3 gene, mutations known to affect neuronal development, and optimize and characterize the ..
- Regulation of Vascular Smooth Muscle Calcium by NADPH RedoxSachin A Gupte; Fiscal Year: 2012..This study, on completion as anticipated, will prove to be useful in developing novel therapies for the treatment of vascular dysfunction in pulmonary hypertension, diabetes, and heart failure. Project Description Page 6 ..
- Abraham A Palmer; Fiscal Year: 2014..We are focusing our efforts on the gene Cacna1c, which is among the most robust findings to emerge from genome-wide association studies (GWAS) of psychiatric ..
- Kirk W Evanson; Fiscal Year: 2014..This research will reveal novel mechanisms of vascular contractility regulation by the CaV1.2 channel C-terminus. ..
- Ebenezer N Yamoah; Fiscal Year: 2014..These studies should reveal how HCs and SGNs coordinate and regulate their electrical and biochemical machinery, information that might be exploited to induce HC and SGN survival after damage. ..
- Tingting Hong; Fiscal Year: 2015..abstract_text> ..
- BIN1 is a mediator and marker of cardiac reserve in heart failure.Tingting Hong; Fiscal Year: 2013....
- Kathleen D Keef; Fiscal Year: 2016..Such information is critical for developing new strategies to help prevent as well as diagnose and treat IAS dysfunction. ..
- Geoffrey S Pitt; Fiscal Year: 2016....
- Mechanisms of Ca2+ and voltage-dependent inactivation Ca channelsMANU B JOHNY; Fiscal Year: 2013..It would also provide a stepping stone to advance our understanding of the mechanistic consequences of lethal channelopathies raising hope for targeted therapeutic interventions. ..
- Sara K Quinney; Fiscal Year: 2016..Pharmacogenetic variations in nifedipine pathway genes, e.g. CYP3A4, CYP3A5, CACNA1C, and CACN1C, will be tested for association with tocolytic response to nifedipine...
- Luis F Santana; Fiscal Year: 2016..This work will generate fundamental information on the mechanisms by which AKAP150 and CaV1.2 channels control of excitability, gene expression, and EC coupling in vascular smooth muscle under physiological and pathological conditions. ..
- Ronghua Zhuge; Fiscal Year: 2016..Such advances will deepen our understanding of ASM biology and facilitate the development of bitter tastants as new bronchodilators. ..
- ANNI SEUNGEUN LEE; Fiscal Year: 2015..Since these analyses will be performed on behaviorally characterized mice, it will allow for association of molecular and behavioral consequences of prefrontal cortical Cav1.2 manipulations. ..
- Geoffrey S Pitt; Fiscal Year: 2016..This proposal addresses how Ca2+ feeds back to regulate cardiac ion channels and examines the structure of critical domains in ion channels that are loci for inherited arrhythmogenic mutations. ..
- Johannes W Hell; Fiscal Year: 2016..Because ? ARs also associate with Cav1.2 in heart, smooth muscle and pancreas, spatially restricted cAMP signaling is of wide interest beyond its role in the brain. ..
- Subcellular Localization of Cav1.2 by alpha-actininJohannes W Hell; Fiscal Year: 2011..2 surface expression and localization is regulated. It will thereby contribute to the development of treatment of these diseases. ..
- POSTSYNAPTIC SIGNALING PATHWAYSJohannes W Hell; Fiscal Year: 2010..2 constitutes, therefore, a potentially effective and specific target for drugs that disrupt some of these interactions, thereby inhibiting adverse signaling events under pathological conditions. ..
- PROSPER N'GOUEMO; Fiscal Year: 2015..PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
- Anjali M Rajadhyaksha; Fiscal Year: 2016..The results obtained from this study could greatly advance the field of cocaine addiction by identifying discrete molecular targets for developing pharmacological treatments for cocaine addicts. ..
- Nipavan Chiamvimonvat; Fiscal Year: 2016..Indeed, novel insights into the atrial-specific and pacemaking tissue-specific ion channels may provide new means to target these channels without interfering with the excitability of ventricular tissues. ..
- Jason L Poulos; Fiscal Year: 2014....
- Jin Peng Szatkiewicz; Fiscal Year: 2014..identification of significant genome wide association for four genes which have confirmed miR-137 target sites (CACNA1C, TCF4, CSMD1, and C10orf26)...
- Modulation of Cav 1.3 L-type Ca2+ channels by PDZ-protein interactionsAmy Lee; Fiscal Year: 2012..We will elucidate new structure/function relationships and modulatory mechanisms, which may be altered in diseased states of the cardiovascular and nervous systems. ..
- Mechanisms of Long-term Cardiac Ion Channel RegulationJonathan Satin; Fiscal Year: 2013..We will determine the compensatory changes of SL Ca handling proteins in response to LTCC blockade. This work may provide a missing molecular link between LTCC function and downstream signaling events. ..
- MANU B JOHNY; Fiscal Year: 2016..3) To deduce, using Aim 2 insight, the mechanism whereby RNA editing of CaV1.3 channels alters their CaM regulation. ..
- Development of High Throughput Assays for N-type Calcium ChannelsEdward Perez Reyes; Fiscal Year: 2007..By targeting an important protein in the pain pathway, the research funded by this grant will provide tools that can be used to screen candidate compounds during the development of novel analgesics. [unreadable] [unreadable] [unreadable]..
- Central Synaptic Transmission in Drosophila.DIANE K O apos DOWD; Fiscal Year: 2010....
- Calmodulin Domain Interactions with L-type Ca2+ ChannelsTURAN EVANS; Fiscal Year: 2007..These studies will lead to a better understanding of the role of CaM domains in regulating conformational change in Cav1.2 which plays an essential role in regulating heartbeat. [unreadable] [unreadable] [unreadable]..
- Austin 5HT Candidate Gene Discovery with C ElegansJ Jay Gargus; Fiscal Year: 2007..unreadable] [unreadable]..
- TRAINING IN MOLECULAR NEUROBIOLOGYWilliam Catterall; Fiscal Year: 2008..The training program will integrate the substantial expertise of this group of faculty in a coordinated pre-doctoral and post-doctoral training effort. ..
- SNP-based lithium treatment outcome diagnosticTroy Bremer; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mitochondrial regulation of calcium signalingJONATHAN JAGGAR; Fiscal Year: 2008..unreadable] [unreadable]..
- MOLECULAR MECHANISMS OF ARRHYTHMIAS DURING HEART FAILURELUIS SANTANA; Fiscal Year: 2004..The proposed work should provide fundamental information on the molecular mechanisms underlying arrhythmias during HF and could provide insights in the development of effective therapeutic strategies for this condition. ..
- Proton as co-transmitter of neuronal signalingMartin Morad; Fiscal Year: 2006..abstract_text> ..
- Ion channel regulation by macromolecular complexesSteven O Marx; Fiscal Year: 2010..Since heart failure and hypertrophy are associated with alterations in PKC activity and Ca2+ homeostasis, understanding the PKC modulation of Cav1.2 may contribute to the development of novel therapeutic agents to treat these disorders. ..