CCL19

Summary

Gene Symbol: CCL19
Description: C-C motif chemokine ligand 19
Alias: CKb11, ELC, MIP-3b, MIP3B, SCYA19, C-C motif chemokine 19, CC chemokine ligand 19, CK beta-11, EBI1-ligand chemokine, MIP-3-beta, beta chemokine exodus-3, chemokine (C-C motif) ligand 19, epstein-Barr virus-induced molecule 1 ligand chemokine, exodus-3, macrophage inflammatory protein 3-beta, small inducible cytokine subfamily A (Cys-Cys), member 19, small-inducible cytokine A19
Species: human
Products:     CCL19

Top Publications

  1. Yamashita M, Iwama N, Date F, Shibata N, Miki H, Yamauchi K, et al. Macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal. Hum Pathol. 2009;40:1553-63 pubmed publisher
    ..Dual immunostaining showed the coexpression of CCL19-a ligand for CCR7-on the lymphatic endothelium...
  2. Liu S, Wu J, Zhang T, Qian B, Wu P, Li L, et al. Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways. Mol Immunol. 2008;46:242-9 pubmed publisher
    ..Additionally, C1q significantly enhances the chemotaxis of LPS-induced mature DC to CCL19 via upregulation of CCR7 expression...
  3. Riera Borrull M, Cuevas V, Alonso B, Vega M, Joven J, Izquierdo E, et al. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation. J Immunol. 2017;199:3858-3869 pubmed publisher
    ..effects can be distinguished from those triggered by LPS, as both agents oppositely regulate the expression of CCL19 and TRIB3 Besides, palmitate conditions macrophages for exacerbated proinflammatory responses (lower IL-10 ..
  4. Van Elssen C, Vanderlocht J, Frings P, Senden Gijsbers B, Schnijderberg M, van Gelder M, et al. Klebsiella pneumoniae-triggered DC recruit human NK cells in a CCR5-dependent manner leading to increased CCL19-responsiveness and activation of NK cells. Eur J Immunol. 2010;40:3138-49 pubmed publisher
    ..pneumoniae-matured DC, resulting in an enhanced migratory responsiveness to the lymph node-associated chemokine CCL19. Bacterial fragment-matured DC do not only mediate NK-cell migration but also meet the prerequisites needed for ..
  5. Nandagopal S, Wu D, Lin F. Combinatorial guidance by CCR7 ligands for T lymphocytes migration in co-existing chemokine fields. PLoS ONE. 2011;6:e18183 pubmed publisher
    ..Furthermore, CCL21 together with another CCR7 ligand, CCL19, direct the navigation and compartmentation of T cells within SLT...
  6. López De Padilla C, Vallejo A, McNallan K, Vehe R, Smith S, Dietz A, et al. Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. Arthritis Rheum. 2007;56:1658-68 pubmed
    ..Mononuclear cells surrounding the blood vessels of inflamed muscle contained abundant transcripts of CCL19 and CCL21, but very little CCL18 transcripts...
  7. Sebastiani S, Danelon G, Gerber B, Uguccioni M. CCL22-induced responses are powerfully enhanced by synergy inducing chemokines via CCR4: evidence for the involvement of first beta-strand of chemokine. Eur J Immunol. 2005;35:746-56 pubmed
    ..Overall, our results indicate that chemokine-induced synergism strengthens leukocyte recruitment towards tissues co-expressing several chemokines. ..
  8. Tucureanu M, Butoi E, Gan A, Stan D, Constantinescu C, Calin M, et al. Amendment of the cytokine profile in macrophages subsequent to their interaction with smooth muscle cells: Differential modulation by fractalkine and resistin. Cytokine. 2016;83:250-261 pubmed publisher
    ..interleukins IL-5 (∼8-fold) and IL-6; (2) an increased Fk expression that in turn induces expression of: CXCL17, CCL19, CCL2, CXCL10, CXCL12, CXCL4, CXCL7, CCL4, CCL18, CXCL16, CXCL1 and IL-27; (3) in the presence of Rs, a ..
  9. LeBlanc D, Schneider M, Angele P, Vollmer G, Docheva D. The effect of estrogen on tendon and ligament metabolism and function. J Steroid Biochem Mol Biol. 2017;172:106-116 pubmed publisher
    ..In particular, the role of estrogen-like compound (ELC) in tendon biology has received until now little attention in modern research, despite ELC being a well-studied and ..
  10. Ueno T, Hara K, Willis M, Malin M, Höpken U, Gray D, et al. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity. 2002;16:205-18 pubmed
    ..The present study shows that a CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture...

Detail Information

Publications62

  1. Yamashita M, Iwama N, Date F, Shibata N, Miki H, Yamauchi K, et al. Macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal. Hum Pathol. 2009;40:1553-63 pubmed publisher
    ..Dual immunostaining showed the coexpression of CCL19-a ligand for CCR7-on the lymphatic endothelium...
  2. Liu S, Wu J, Zhang T, Qian B, Wu P, Li L, et al. Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways. Mol Immunol. 2008;46:242-9 pubmed publisher
    ..Additionally, C1q significantly enhances the chemotaxis of LPS-induced mature DC to CCL19 via upregulation of CCR7 expression...
  3. Riera Borrull M, Cuevas V, Alonso B, Vega M, Joven J, Izquierdo E, et al. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation. J Immunol. 2017;199:3858-3869 pubmed publisher
    ..effects can be distinguished from those triggered by LPS, as both agents oppositely regulate the expression of CCL19 and TRIB3 Besides, palmitate conditions macrophages for exacerbated proinflammatory responses (lower IL-10 ..
  4. Van Elssen C, Vanderlocht J, Frings P, Senden Gijsbers B, Schnijderberg M, van Gelder M, et al. Klebsiella pneumoniae-triggered DC recruit human NK cells in a CCR5-dependent manner leading to increased CCL19-responsiveness and activation of NK cells. Eur J Immunol. 2010;40:3138-49 pubmed publisher
    ..pneumoniae-matured DC, resulting in an enhanced migratory responsiveness to the lymph node-associated chemokine CCL19. Bacterial fragment-matured DC do not only mediate NK-cell migration but also meet the prerequisites needed for ..
  5. Nandagopal S, Wu D, Lin F. Combinatorial guidance by CCR7 ligands for T lymphocytes migration in co-existing chemokine fields. PLoS ONE. 2011;6:e18183 pubmed publisher
    ..Furthermore, CCL21 together with another CCR7 ligand, CCL19, direct the navigation and compartmentation of T cells within SLT...
  6. López De Padilla C, Vallejo A, McNallan K, Vehe R, Smith S, Dietz A, et al. Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. Arthritis Rheum. 2007;56:1658-68 pubmed
    ..Mononuclear cells surrounding the blood vessels of inflamed muscle contained abundant transcripts of CCL19 and CCL21, but very little CCL18 transcripts...
  7. Sebastiani S, Danelon G, Gerber B, Uguccioni M. CCL22-induced responses are powerfully enhanced by synergy inducing chemokines via CCR4: evidence for the involvement of first beta-strand of chemokine. Eur J Immunol. 2005;35:746-56 pubmed
    ..Overall, our results indicate that chemokine-induced synergism strengthens leukocyte recruitment towards tissues co-expressing several chemokines. ..
  8. Tucureanu M, Butoi E, Gan A, Stan D, Constantinescu C, Calin M, et al. Amendment of the cytokine profile in macrophages subsequent to their interaction with smooth muscle cells: Differential modulation by fractalkine and resistin. Cytokine. 2016;83:250-261 pubmed publisher
    ..interleukins IL-5 (∼8-fold) and IL-6; (2) an increased Fk expression that in turn induces expression of: CXCL17, CCL19, CCL2, CXCL10, CXCL12, CXCL4, CXCL7, CCL4, CCL18, CXCL16, CXCL1 and IL-27; (3) in the presence of Rs, a ..
  9. LeBlanc D, Schneider M, Angele P, Vollmer G, Docheva D. The effect of estrogen on tendon and ligament metabolism and function. J Steroid Biochem Mol Biol. 2017;172:106-116 pubmed publisher
    ..In particular, the role of estrogen-like compound (ELC) in tendon biology has received until now little attention in modern research, despite ELC being a well-studied and ..
  10. Ueno T, Hara K, Willis M, Malin M, Höpken U, Gray D, et al. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity. 2002;16:205-18 pubmed
    ..The present study shows that a CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture...
  11. Chandrasekaran P, Buckley M, Moore V, Wang L, Kehrl J, Venkatesan S. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination. J Biol Chem. 2012;287:41481-98 pubmed publisher
    ..By specifically degrading Gα(i2), Nef directly subverts leukocyte migration and homing. Impaired trafficking and homing of HIV Nef-expressing lymphocytes probably contributes to early immune dysfunction following HIV infection. ..
  12. Jung Y, Kim H, Perry C, Kaech S. CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. Proc Natl Acad Sci U S A. 2016;113:8278-83 pubmed publisher
    C-C receptor 7 (CCR7) is important to allow T cells and dendritic cells to migrate toward CCL19- and CCL21-producing cells in the T-cell zone of the spleen and lymph nodes...
  13. Sepahi A, Casadei E, Tacchi L, Munoz P, LaPatra S, Salinas I. Tissue Microenvironments in the Nasal Epithelium of Rainbow Trout (Oncorhynchus mykiss) Define Two Distinct CD8α+ Cell Populations and Establish Regional Immunity. J Immunol. 2016;197:4453-4463 pubmed
    ..The grouping of CD8α+ cells may be explained by the greater expression of CCL19, ICAM-1, and VCAM-1 in the mucosal tip compared with the neuroepithelium...
  14. Codreanu S, Hoeksema M, Slebos R, Zimmerman L, Rahman S, Li M, et al. Identification of Proteomic Features To Distinguish Benign Pulmonary Nodules from Lung Adenocarcinoma. J Proteome Res. 2017;16:3266-3276 pubmed publisher
    ..PRM analyses confirmed significant nodule-specific abundance of 10 proteins including ALOX5, ALOX5AP, CCL19, CILP1, COL5A2, ITGB2, ITGAX, PTPRE, S100A12, and SLC2A3 and significant ADC-specific abundance of CEACAM6, CRABP2,..
  15. Saleh S, Lu H, Evans V, Harisson D, Zhou J, Jaworowski A, et al. HIV integration and the establishment of latency in CCL19-treated resting CD4(+) T cells require activation of NF-κB. Retrovirology. 2016;13:49 pubmed publisher
    ..reported that HIV latency could be established in resting CD4(+) T cells in the presence of the chemokine CCL19. To define how CCL19 facilitated the establishment of latent HIV infection, the role of chemokine receptor ..
  16. Gracida X, Dion M, Harris G, Zhang Y, Calarco J. An Elongin-Cullin-SOCS Box Complex Regulates Stress-Induced Serotonergic Neuromodulation. Cell Rep. 2017;21:3089-3101 pubmed publisher
    ..We identified elc-2, an Elongin C ortholog, specifically expressed in stress-sensing amphid neuron dual ciliated sensory ending (ADF) ..
  17. Bardi G, Niggli V, Loetscher P. Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes. FEBS Lett. 2003;542:79-83 pubmed
    ..kinase (ERK)-2 in the polarization and migration of T lymphocytes in response to the CCR7 ligands EBI1 ligand chemokine (ELC; CCL19) and secondary lymphoid-tissue chemokine (SLC; CCL21)...
  18. Curreli S, Wong B, Latinovic O, Konstantopoulos K, Stamatos N. Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration. J Leukoc Biol. 2016;100:1323-1334 pubmed
    ..actin filaments at the plasma membrane and increased transwell migration in the absence or presence of chemokine CCL19. Microfluidic chamber assays failed to demonstrate consistent changes in speed of Sema3C-treated DCs, suggesting ..
  19. Rossi D, Vicari A, Franz Bacon K, McClanahan T, Zlotnik A. Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. J Immunol. 1997;158:1033-6 pubmed
    ..In contrast with other CC chemokines, MIP-3beta maps to chromosome 9. Here we show the importance of bioinformatics to discover new molecules with possible therapeutic effects and regulatory functions. ..
  20. Chen F, Lu X, Nie L, Ning Y, Chen J. Molecular characterization of a CC motif chemokine 19-like gene in ayu (Plecoglossus altivelis) and its role in leukocyte trafficking. Fish Shellfish Immunol. 2017;72:301-308 pubmed publisher
    The CC motif chemokine 19 (CCL19) functions in acute inflammation by recruiting lymphocytes and other cells. However, CCL19 has only been investigated in few fish species...
  21. Plesingerova H, Janovská P, Mishra A, Smyčková L, Poppova L, Libra A, et al. Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia. Haematologica. 2017;: pubmed publisher
    ..lymphocytic leukemia patients with unmutated IGHV and high COBLL1 show impaired motility and chemotaxis towards CCL19 and CXCL12 as well as enhanced B-cell receptor signaling pathway activation demonstrated by increased PLCγ2 and ..
  22. Zhang X, Wang Y, Cao Y, Zhang X, Zhao H. Increased CCL19 expression is associated with progression in cervical cancer. Oncotarget. 2017;8:73817-73825 pubmed publisher
    ..b>CCL19 is highly expressed in human cancer cells, and ligand CCL19 binding to CCR7 induces actin polymerization and ..
  23. Scandella E, Men Y, Legler D, Gillessen S, Prikler L, Ludewig B, et al. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood. 2004;103:1595-601 pubmed
    ..Activated DCs home to lymphoid organs, where the CCR7 ligands CCL19 and CCL21 are expressed...
  24. König K, Diehl L, Rommerscheidt Fuss U, Golletz C, Quast T, Kahl P, et al. Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration. J Immunol. 2010;185:1466-75 pubmed publisher
    We identified the four-and-a-half LIM domain protein 2 (FHL2) as a novel regulator of CCL19-induced dendritic cell (DC) migration...
  25. Paoletti S, Petkovic V, Sebastiani S, Danelon M, Uguccioni M, Gerber B. A rich chemokine environment strongly enhances leukocyte migration and activities. Blood. 2005;105:3405-12 pubmed
    ..Chemokine-induced synergism might provide an amplification system in "chemokine-rich" tissues, rendering leukocytes more competent to respond to migratory cues. ..
  26. Jongen Lavrencic M, Salesse S, Delwel R, Verfaillie C. BCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cells. Leukemia. 2005;19:373-80 pubmed
    ..Compared with GFP UCB or normal (NL) BM CD34+ cells, p210 UCB and CML CD34+ cells migrated poorly towards the CCR7 ligands, CCL19 and CCL21, suggesting a possible role for CCR7 in the abnormal migratory behavior of CML CD34+ cells.
  27. Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry M, et al. CCR7 is involved in the migration of neutrophils to lymph nodes. Blood. 2011;117:1196-204 pubmed publisher
    ..In vitro, stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21...
  28. Wang X, Yuling H, Yanping J, Xinti T, Yaofang Y, Feng Y, et al. CCL19 and CXCL13 synergistically regulate interaction between B cell acute lymphocytic leukemia CD23+CD5+ B Cells and CD8+ T cells. J Immunol. 2007;179:2880-8 pubmed
    ..In a previous study, we have reported that ligation of CCL19-CCR7 and CXCL13-CXCR5 activates paternally expressed gene 10 (PEG10), resulting in an enhancement of apoptotic ..
  29. Townson J, Nibbs R. Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. Eur J Immunol. 2002;32:1230-41 pubmed
    ..This study identifies murine CCX-CKR, reveals complex regulation of CCX-CKR gene expression in mouse and man, and is suggestive of non-leukocytic targets for MIP-3beta/CCL19, SLC/CCL21 and TECK/CCL25.
  30. Oliveira Neto H, de Souza P, da Silva M, Mendonça E, Silva T, Batista A. The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis. Tumour Biol. 2013;34:65-70 pubmed publisher
    The purpose of this study is to determine the expression of CCL19, CCL21, and CCR7 in samples of oral squamous cell carcinoma (OSCC) and their relationship with clinical and microscopic parameters...
  31. Yanagihara S, Komura E, Nagafune J, Watarai H, Yamaguchi Y. EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J Immunol. 1998;161:3096-102 pubmed
    ..The EBI1/CCR7 expressed in mature DC is functional because ELC/MIP-3beta, recently identified as a ligand of EBI1/CCR7, induces a rise in intracellular free calcium ..
  32. Liu H, Shi L, Hu F, Yao H, Li Z, Jia Y. [Increased serum C-C chemokine ligand 19 levels correlated with B cell abnormalities in systemic lupus erythematosus]. Beijing Da Xue Xue Bao Yi Xue Ban. 2017;49:829-834 pubmed
    To detect the levels of serum C-C chemokine ligand 19 (CCL19) in patients with systemic lupus erythematosus (SLE) and to evaluate the correlation between CCL19 expression and clinical features and laboratory parameters, trying to reveal ..
  33. Katou F, Ohtani H, Nakayama T, Nagura H, Yoshie O, Motegi K. Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin. J Pathol. 2003;199:98-106 pubmed
    ..in chronically inflamed skin and LNs, the present study focuses on another chemokine system, namely CCL19 (EBI1 ligand chemokine; ELC), CCL21 (secondary lymphoid tissue chemokine; SLC) and their shared receptor, CCR7...
  34. Pietila T, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I. Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells. J Immunol. 2007;178:253-61 pubmed
    b>CCL19 chemokine has a central role in dendritic cell (DC) biology regulating DC traffic and recruitment of naive T cells to the vicinity of activated DCs...
  35. Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, et al. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Res. 2017;27:352-372 pubmed publisher
    ..In response to oxLDL, macrophages show reduced migratory capacity toward chemokines CCL19 and CCL21; this capacity can be restored by blocking CD146...
  36. Hansson M, Lundgren A, Elgbratt K, Quiding Jarbrink M, Svennerholm A, Johansson E. Dendritic cells express CCR7 and migrate in response to CCL19 (MIP-3beta) after exposure to Helicobacter pylori. Microbes Infect. 2006;8:841-50 pubmed
    ..of DC to lymph nodes is regulated by chemokine receptor CCR7, expressed on mature DC, and the CCR7 ligands CCL19 and CCL21...
  37. Gosling J, Dairaghi D, Wang Y, Hanley M, Talbot D, Miao Z, et al. Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000;164:2851-6 pubmed
    ..These cells adhered to stalkokines representing ELC, a chemokine previously thought to bind only CCR7...
  38. Machelart A, Khadrawi A, Demars A, Willemart K, De Trez C, Letesson J, et al. Chronic Brucella Infection Induces Selective and Persistent Interferon Gamma-Dependent Alterations of Marginal Zone Macrophages in the Spleen. Infect Immun. 2017;85: pubmed publisher
    ..or tumor necrosis factor alpha receptor 1 (TNF-αR1) signaling pathways and is not correlated to an alteration of CCL19, CCL21, and CXCL13 chemokine mRNA expression...
  39. Liu Y, Luo S, Kou L, Tang C, Huang R, Pei Z, et al. Ischemic stroke damages the intestinal mucosa and induces alteration of the intestinal lymphocytes and CCL19 mRNA in rats. Neurosci Lett. 2017;658:165-170 pubmed publisher
    ..mucosa, lymphocytes of the gut-associated lymphoid tissue (GALT), and the intestinal expression of CCL25 mRNA and CCL19 mRNA of stroke. Rats were randomly divided into stroke, sham, and control groups...
  40. Ishihara S, Shoda T, Ishimura N, Ohta S, Ono J, Azuma Y, et al. Serum Biomarkers for the Diagnosis of Eosinophilic Esophagitis and Eosinophilic Gastroenteritis. Intern Med. 2017;56:2819-2825 pubmed publisher
    ..chemokine (CTACK)/CCL27, stromal cell-derived factor (SDF)-1/CXCL12, macrophage inflammatory protein (MIP)-3β/CCL19, and squamous cell carcinoma antigen (SCCA) 2 levels were elevated only in patients with eosinophilic esophagitis...
  41. Krumbholz M, Theil D, Steinmeyer F, Cepok S, Hemmer B, Hofbauer M, et al. CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. J Neuroimmunol. 2007;190:72-9 pubmed
    b>CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response and establishing immunological tolerance...
  42. Nobile C, Rudnicka D, Hasan M, Aulner N, Porrot F, Machu C, et al. HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. J Virol. 2010;84:2282-93 pubmed publisher
    ..cells to fibronectin, their spontaneous motility, and their migration toward chemokines (CXCL12, CCL3, and CCL19) were all significantly decreased...
  43. Giordano D, Magaletti D, Clark E. Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19. Blood. 2006;107:1537-45 pubmed
    ..Although LPS up-regulates CCR7 on DCs, a second signal is required to enable them to migrate toward the chemokine CCL19 (MIP-3beta)...
  44. Sobhkhez M, Krasnov A, Chang C, Robertsen B. Transcriptome analysis of plasmid-induced genes sheds light on the role of type I IFN as adjuvant in DNA vaccine against infectious salmon anemia virus. PLoS ONE. 2017;12:e0188456 pubmed publisher
    ..Attraction of lymphocytes was likely caused by the induction of chemokines homologous to mammalian CCL5, CCL8, CCL19 and CXCL10. IFN may possibly also co-stimulate activation of lymphocytes as suggested by studies in mammals...