CCR7

Summary

Gene Symbol: CCR7
Description: C-C motif chemokine receptor 7
Alias: BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C chemokine receptor type 7, Bukitt's lymphoma receptor 2, CC chemokine receptor 7, EBV-induced G protein-coupled receptor 1, Epstein-Barr virus induced gene 1, Epstein-Barr virus-induced G-protein coupled receptor 1, MIP-3 beta receptor, chemokine (C-C motif) receptor 7, lymphocyte-specific G protein-coupled peptide receptor
Species: human

Top Publications

  1. doi CCR7 and its ligands: balancing immunity and tolerance
    Reinhold Forster
    Institute of Immunology, Hannover Medical School 30625 Hannover, Germany
    Nat Rev Immunol 8:362-71. 2008
  2. ncbi Matrix metalloproteinase-9 is up-regulated by CCL21/CCR7 interaction via extracellular signal-regulated kinase-1/2 signaling and is involved in CCL21-driven B-cell chronic lymphocytic leukemia cell invasion and migration
    Javier Redondo-Muñoz
    Departamento de Fisiopatología Celular y Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid
    Blood 111:383-6. 2008
  3. ncbi Kinetics of CCR7 expression differ between primary activation and effector memory states of T(H)1 and T(H)2 cells
    Peter A Calabresi
    Department of Neurology, BRB 12 027, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    J Neuroimmunol 139:58-65. 2003
  4. pmc Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1
    J R Taylor
    Department of Microbiology and Myles H Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 75:8752-60. 2001
  5. ncbi Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1
    Julia L Wilson
    Translational Oncology Laboratory, Cancer Research UK, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Cancer Res 66:11802-7. 2006
  6. ncbi HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    FASEB J 21:2323-34. 2007
  7. pmc HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype
    Simona Fiorentini
    Sections of Microbiology, General Pathology and Immunology, and Pathology, University of Brescia, I 25123 Brescia, Italy
    Proc Natl Acad Sci U S A 105:3867-72. 2008
  8. doi The effect of allogeneic in vitro stimulation and in vivo immunization on memory CD4(+) T-cell APOBEC3G expression and HIV-1 infectivity
    Jeffrey Pido-Lopez
    Kings College London, Guy s Hospital, London, UK
    Eur J Immunol 39:1956-65. 2009
  9. ncbi Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21
    Melissa A Byers
    Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 181:4723-32. 2008
  10. pmc Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors
    M Birkenbach
    Department of Medicine, Harvard University, Boston, Massachusetts 02115
    J Virol 67:2209-20. 1993

Research Grants

  1. MICHAEL LORAN DUSTIN; Fiscal Year: 2014
  2. Joel D Ernst; Fiscal Year: 2016
  3. Frances E Lund; Fiscal Year: 2016
  4. Steven M Dubinett; Fiscal Year: 2016
  5. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
  6. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
  7. Role and Regulation of CCR7 in Regression of Atherosclerotic Lesions
    Jonathan E Feig; Fiscal Year: 2010
  8. Fadi G Lakkis; Fiscal Year: 2016
  9. Treg Migration in GVHD
    Jonathan Serody; Fiscal Year: 2009
  10. Engineering hematopoietic progenitors for efficient migration to the thymus
    Avinash Bhandoola; Fiscal Year: 2010

Detail Information

Publications222 found, 100 shown here

  1. doi CCR7 and its ligands: balancing immunity and tolerance
    Reinhold Forster
    Institute of Immunology, Hannover Medical School 30625 Hannover, Germany
    Nat Rev Immunol 8:362-71. 2008
    ..Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance...
  2. ncbi Matrix metalloproteinase-9 is up-regulated by CCL21/CCR7 interaction via extracellular signal-regulated kinase-1/2 signaling and is involved in CCL21-driven B-cell chronic lymphocytic leukemia cell invasion and migration
    Javier Redondo-Muñoz
    Departamento de Fisiopatología Celular y Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid
    Blood 111:383-6. 2008
    ..Indeed, CCR7 (the CCL21 receptor), as well as matrix metalloproteinase-9 (MMP-9), are overexpressed in infiltrating B-CLL cells...
  3. ncbi Kinetics of CCR7 expression differ between primary activation and effector memory states of T(H)1 and T(H)2 cells
    Peter A Calabresi
    Department of Neurology, BRB 12 027, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    J Neuroimmunol 139:58-65. 2003
    We explored the kinetics of CCR7 expression on T(H)1 and T(H)2 polarized cells as well as on antigen-specific T cell lines at various stages of differentiation...
  4. pmc Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1
    J R Taylor
    Department of Microbiology and Myles H Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 75:8752-60. 2001
    ..We assayed the expression and function of the major HIV-1 coreceptors, CCR5 and CXCR4, as well as CCR4 and CCR7 as controls, on human thymocytes. We detected CCR5 on 2...
  5. ncbi Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1
    Julia L Wilson
    Translational Oncology Laboratory, Cancer Research UK, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Cancer Res 66:11802-7. 2006
    Endothelin expression is increased in breast tumors and is associated with invasion and metastasis, whereas CCR7 expression by breast tumor cells may have a role in the organ specificity of breast cancer spread...
  6. ncbi HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    FASEB J 21:2323-34. 2007
    ..Our findings suggest that the Nef-induced dysregulation in the DC/NK cell crosstalk may represent a potential mechanism through which HIV escapes innate immune surveillance...
  7. pmc HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype
    Simona Fiorentini
    Sections of Microbiology, General Pathology and Immunology, and Pathology, University of Brescia, I 25123 Brescia, Italy
    Proc Natl Acad Sci U S A 105:3867-72. 2008
    ..Upon p17 treatment, pDCs undergo phenotypic differentiation with up-regulation of CCR7. A chemotaxis assay reveals that p17-treated pDCs migrate in response to CCL19, suggesting that these cells may ..
  8. doi The effect of allogeneic in vitro stimulation and in vivo immunization on memory CD4(+) T-cell APOBEC3G expression and HIV-1 infectivity
    Jeffrey Pido-Lopez
    Kings College London, Guy s Hospital, London, UK
    Eur J Immunol 39:1956-65. 2009
    ..Alloimmune-induced A3G was found to be significantly increased in CD45RA(-), CCR5(+) and CD45RA(-)CCR7(-) subsets of effector memory T cells...
  9. ncbi Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21
    Melissa A Byers
    Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 181:4723-32. 2008
    ..The C-C chemokine receptor (CCR7) G protein-coupled receptor is expressed on naive T cells, dendritic cells, and NK cells and has two endogenous ..
  10. pmc Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors
    M Birkenbach
    Department of Medicine, Harvard University, Boston, Massachusetts 02115
    J Virol 67:2209-20. 1993
    ..These predicted G protein-coupled peptide receptors are more likely to be mediators of EBV effects on B lymphocytes or of normal lymphocyte functions than are genes previously known to be up-regulated by EBV infection...
  11. ncbi Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7
    R Yoshida
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:13803-9. 1997
    ..We termed this novel chemokine from EBI1-Ligand Chemokine as ELC (see below). The ELC mRNA was most strongly expressed in the thymus and lymph nodes...
  12. ncbi Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7
    R Yoshida
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 273:7118-22. 1998
    ..The SLC gene and the gene encoding another lymphocyte-specific CC chemokine, EBI1-ligand chemokine (ELC), form a mini-cluster at human chromosome 9p13...
  13. pmc 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7
    J J Campbell
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University Medical School, Stanford, California 94305, USA
    J Cell Biol 141:1053-9. 1998
    ..We show that 6CK/SLC is an agonist for the lymphocyte chemoattractant receptor, CCR7 (EBI-1, BLR-2), previously described as a receptor for the related beta chemokine MIP-3beta (ELC or Exodus-3)...
  14. ncbi EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation
    S Yanagihara
    Pharmaceutical Research Laboratory, Kirin Brewery Co, Ltd, Takasaki, Gunma, Japan
    J Immunol 161:3096-102. 1998
    ..influence migration and are selectively expressed in mature DC, we have discovered that the chemokine receptor, EBI1/CCR7, is strikingly up-regulated upon maturation in three distinct culture systems: 1) mouse bone marrow-derived DC,..
  15. ncbi CCR7 expression and memory T cell diversity in humans
    J J Campbell
    Joint Program in Transfusion Medicine, Children s Hospital, and Harvard Medical School, Department of Pathology, Boston, MA 02115, USA
    J Immunol 166:877-84. 2001
    b>CCR7, along with L-selectin and LFA-1, mediates homing of T cells to secondary lymphoid organs via high endothelial venules (HEV)...
  16. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Here we report that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases...
  17. ncbi Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis
    Bernhard Banas
    Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Immunol 168:4301-7. 2002
    ..By immunohistochemistry we found the chemokine receptor CCR7 expressed in a mesangial pattern while the CCR7 ligand SLC/CCL21 showed a podocyte-specific expression...
  18. ncbi Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis
    Iwao Takanami
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Int J Cancer 105:186-9. 2003
    ..b>CCR7 has been shown to play an important role in tumor cell migration and lymph node metastasis...
  19. ncbi CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2
    Elke Scandella
    Department of esearch, Cantonal Hospital St Gallen, Switzerland
    Blood 103:1595-601. 2004
    ..When activated with inflammatory stimuli, the chemokine receptor CCR7 is up-regulated on DCs. Activated DCs home to lymphoid organs, where the CCR7 ligands CCL19 and CCL21 are expressed...
  20. pmc Impaired lymphoid chemokine-mediated migration due to a block on the chemokine receptor switch in human cytomegalovirus-infected dendritic cells
    Magdalena Moutaftsi
    Section of Infection and Immunity Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    J Virol 78:3046-54. 2004
    ..DC migration is blocked by viral impairment of the chemokine receptor switch at the level of the expression of CCR7 molecules...
  21. ncbi CCR7 directs the migration of thymocytes into the thymic medulla
    Joanne Kwan
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 172:3999-4007. 2004
    ..b>CCR7, the receptor for the medullary chemokines CCL19 and CCL21, is induced on thymocytes during their positive ..
  22. ncbi Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells
    Noelia Sanchez-Sanchez
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Blood 104:619-25. 2004
    Acquisition of CCR7 expression is an important phenotype change during dendritic cell (DC) maturation that endows these cells with the capability to migrate to lymph nodes...
  23. ncbi CCL21 chemokine regulates chemokine receptor CCR7 bearing malignant melanoma cells
    Hiroya Takeuchi
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Clin Cancer Res 10:2351-8. 2004
    ..CCL21/SLC) regulates the homing of naïve T cells and dendritic cells that express CC-chemokine receptor 7 (CCR7) from distant sites to lymphoid tissue such as lymph nodes...
  24. ncbi Expression of CCR7 in multiple sclerosis: implications for CNS immunity
    Pia Kivisakk
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Neurol 55:627-38. 2004
    ..We studied the expression of CCR7, a chemokine receptor required for migration of T cells and dendritic cells (DCs) to lymphoid organs, in the CNS of ..
  25. pmc Effects of chemokines on proliferation and apoptosis of human mesangial cells
    Markus Wornle
    Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    BMC Nephrol 5:8. 2004
    ..Expression of chemokines and chemokine receptors by intrinsic renal cells, e.g. SLC/CCL21 on podocytes and CCR7 on MC is suggested to play a pivotal role during these processes...
  26. ncbi Binding of the chemokine SLC/CCL21 to its receptor CCR7 increases adhesive properties of human mesangial cells
    Bernhard Banas
    Nephrologisches Zentrum, Medizinische Poliklinik, Ludwig Maximilians Universitat Munchen, Germany
    Kidney Int 66:2256-63. 2004
    ..A constitutive expression of the chemokine SLC/CCL21 on human podocytes and of its corresponding receptor CCR7 on mesangial cells was shown before...
  27. ncbi Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells
    Takuji Mori
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California, 90404, USA
    Cancer Res 65:1800-7. 2005
    ..We hypothesized that chemokine receptors C-C chemokine receptor 7 (CCR7) and C-X-C chemokine receptor 4 (CXCR4) on melanoma cells undergo epigenetic regulation...
  28. ncbi The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed
    Lorena Riol-Blanco
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 174:4070-80. 2005
    b>CCR7 is necessary to direct dendritic cells (DCs) to secondary lymphoid nodes and to elicit an adaptative immune response. Despite its importance, little is known about the molecular mechanisms used by CCR7 to direct DCs to lymph nodes...
  29. ncbi CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer
    Neslihan Cabioglu
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:5686-93. 2005
    The chemokine receptors CCR7 and CXCR4 have been shown to play an important role in cancer metastasis...
  30. ncbi Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis
    Jeong Whun Kim
    Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA
    Clin Cancer Res 11:7901-10. 2005
    Chemokine C receptor 7 (CCR7) expression is important for lymphocyte homing to tissues. We hypothesized that CCR7 also plays a role in CD8(+) T-cell protection from apoptosis...
  31. ncbi The multiple personalities of the chemokine receptor CCR7 in dendritic cells
    Noelia Sanchez-Sanchez
    Department of Immunology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 176:5153-9. 2006
    b>CCR7 was described initially as a potent leukocyte chemotactic receptor that was later shown to be responsible of directing the migration of dendritic cells (DCs) to the lymph nodes where these cells play an important role in the ..
  32. ncbi Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer
    Carl C Schimanski
    First Department of Internal Medicine, Johannes Gutenberg University of Mainz, D 55101 Mainz, Germany
    Oncol Rep 16:109-13. 2006
    ..In diverse tumor entities, expression of the chemokine receptor, CCR7, has been linked to tumor dissemination and poor prognosis...
  33. ncbi Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, and Inner Mongolia Agriculture University Hospital, Huhehaote, China
    Ann Oncol 18:70-6. 2007
    The chemokine receptors CXCR4 and CCR7 have been suggested to play an important role in cancer invasion and metastasis. The expression of these receptors in human cervical cancer, however, has seldom been characterized.
  34. doi Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells
    Mei Ren Pan
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    J Biol Chem 283:11155-63. 2008
    ..However, the mechanism by which COX-2 increases the invasion of cancer cells to lymph node is unclear. CCR7 is a chemokine receptor that plays important roles in the mediation of migration of leukocytes and dendritic cells ..
  35. ncbi A critical role of CCR7 in invasiveness and metastasis of SW620 colon cancer cell in vitro and in vivo
    Shuyi Yu
    Central South University School of Bioscience and Technology, Changsha, China
    Cancer Biol Ther 7:1037-43. 2008
    Tumor cell migration and metastasis are critically regulated by chemokines and their receptors. CC Chemokine Receptor 7 (CCR7) plays a critical role in mediating chemotactic and invasive responses in cancers...
  36. doi Chemokine receptor CCR7 expression correlates with lymph node metastasis in pancreatic cancer
    Bunzo Nakata
    Department of Surgical Oncology, Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Osaka, Japan
    Oncology 74:69-75. 2008
    The clinical significance of chemokine receptor CCR7 expression in pancreatic ductal cancer was investigated.
  37. doi Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells
    M Kochetkova
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia
    Cell Death Differ 16:664-73. 2009
    ..We report here a novel property of the chemokine receptors CXCR4 and CCR7 in inhibiting detachment-induced cell death--anoikis, which is believed to be one of the major blocks in the ..
  38. ncbi High CCR7 mRNA expression of cancer cells is associated with lymph node involvement in patients with esophageal squamous cell carcinoma
    Koichiro Ishida
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama 641 8510, Japan
    Int J Oncol 34:915-22. 2009
    ..In particular, CCR7 has been reported to be associated with LN metastases by immunohistochemistry...
  39. pmc CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
    Silvia Buonamici
    Department of Pathology and New York University Cancer Institute, New York 10016, USA
    Nature 459:1000-4. 2009
    ..Here we show, using T-ALL animal modelling and gene-expression profiling, that the chemokine receptor CCR7 (ref. 5) is the essential adhesion signal required for the targeting of leukaemic T-cells into the CNS...
  40. doi Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck
    Fa Yu Liu
    Oral and Maxillofacial Tumor Center, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, No 117, Nanjing Bei Jie, Heping District, Shenyang, Liaoning 110002, China
    Br J Oral Maxillofac Surg 48:291-6. 2010
    Metastatic squamous cell carcinoma (SCC) of the head and neck expresses chemokine receptor 7 (CCR7), which activates phosphoinositide-3 kinase (PI3K) to promote invasion and survival of SCC cells in the head and neck...
  41. ncbi The chemokine receptor 7 regulates cell adhesion and migration via beta1 integrin in metastatic squamous cell carcinoma of the head and neck
    Peng Li
    Department of Oromaxillofacial Head and Neck Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, P R China
    Oncol Rep 24:989-95. 2010
    ..Chemokine receptor 7 (CCR7) has been shown to regulate integrin which can then facilitate adhesion of cancer cells to and/or migration through ..
  42. pmc CCR7/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1/2 in primary T lymphocytes
    Laura A Shannon
    Department of Microbiology, Molecular Genetics, and Immunology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 285:38781-7. 2010
    b>CCR7 binds to its cognate ligand, CCL21, to mediate the migration of circulating naive T lymphocytes to the lymph nodes...
  43. doi CCR7 is involved in the migration of neutrophils to lymph nodes
    Celine Beauvillain
    INSERM Unité 892, Centre de Recherche en Cancérologie Nantes Angers, 4 rue Larrey, Angers, France
    Blood 117:1196-204. 2011
    ..We demonstrate that a subpopulation of human and mouse neutrophils express CCR7. CCR7 is rapidly expressed at the membrane upon stimulation...
  44. doi NF-κB participates in chemokine receptor 7-mediated cell survival in metastatic squamous cell carcinoma of the head and neck
    Fa Yu Liu
    Department of Oromaxillofacial Head and Neck Surgery, School of Stomatology, China Medical University, No 117, Nanjing Bei Jie, Heping District, Shenyang, Liaoning 110002, PR China
    Oncol Rep 25:383-91. 2011
    Metastatic squamous cell carcinoma of the head and neck (SCCHN) has been shown to express chemokine receptor 7 (CCR7), which activates phosphoinositide-3 kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signal pathway to promote ..
  45. doi CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck
    Zhen Jin Zhao
    Department of Orthodontics, School of Stomatology, China Medical University, No 117 Nanjing Bei Street, Heping District, Shenyang, Liaoning 110002, PR China
    Oncol Rep 25:729-37. 2011
    Metastatic squamous cell carcinoma of the head and neck (SCCHN) has been shown to express chemokine receptor 7 (CCR7), which activates phosphoinositide-3 kinase (PI3K) to promote invasion and survival of SCCHN cells...
  46. doi Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3
    Peng Li
    Department of Oromaxillofacial Head and Neck Surgery, School of Stomatology, China Medical University, Heping District, Shenyang, Liaoning 110002, PR China
    Int J Mol Med 27:679-87. 2011
    ..Although evidence shows that the chemokine receptor 7 (CCR7) and its ligand CCL19 may regulate tumor dissemination, their role in SCCHN is not clearly defined...
  47. pmc CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells
    Ying Xu
    Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China
    PLoS ONE 6:e21119. 2011
    C-C chemokine receptor 7 (CCR7) contributes to the survival of certain cancer cell lines, but its role in the proliferation of human non-small cell lung cancer (NSCLC) cells remains vague...
  48. doi PKCα take part in CCR7/NF-κB autocrine signaling loop in CCR7-positive squamous cell carcinoma of head and neck
    Zhao Zhen-Jin
    Department of Orthodontics, School of Stomatology, China Medical University, No 117 Nanjing Bei Jie, Heping District, Shenyang, Liaoning 110002, People s Republic of China
    Mol Cell Biochem 357:181-7. 2011
    Metastatic squamous cell carcinoma of head and neck (SCCHN) has been shown to express chemokine receptor 7 (CCR7)...
  49. pmc Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN)
    Yvonne K Mburu
    Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 287:3581-90. 2012
    The chemokine receptor CCR7 is a seven-transmembrane domain G-protein-coupled receptor that facilitates leukocyte migration to regional lymph nodes...
  50. pmc CCL21/CCR7 prevents apoptosis via the ERK pathway in human non-small cell lung cancer cells
    Ying Xu
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China
    PLoS ONE 7:e33262. 2012
    Previously, we confirmed that C-C chemokine receptor 7 (CCR7) promotes cell proliferation via the extracellular signal-regulated kinase (ERK) pathway, but its role in apoptosis of non-small cell lung cancer (NSCLC) cell lines remains ..
  51. doi Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediated signaling
    Eiji Umemoto
    Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    J Immunol 189:191-9. 2012
    ..that pDCs constitutively migrate into the splenic white pulp (WP) in a manner dependent on the chemokine receptors CCR7 and CXCR4...
  52. doi Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells
    Chun Wei Chuang
    Institute of Biomedical Sciences, National Sun Yat Sen University, Kaohsiung, Taiwan
    J Cell Physiol 228:341-8. 2013
    ..Our previous results demonstrate that COX-2 and its metabolite prostaglandin E2 (PGE2) stimulate the expression of CCR7 chemokine receptor via EP2/EP4 receptors to promote lymphatic invasion in breast cancer cells...
  53. doi Chemokine receptor 7 via proline-rich tyrosine kinase-2 upregulates the chemotaxis and migration ability of squamous cell carcinoma of the head and neck
    Liangliang Yang
    Department of Oromaxillofacial Head and Neck Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, PR China
    Oncol Rep 28:1659-64. 2012
    ..The chemokine receptor 7 (CCR7) has recently been shown to play an important role in regional lymph node metastasis of squamous cell ..
  54. doi The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer
    Wei Ning Wang
    Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, 410008, China
    Tumour Biol 34:1865-71. 2013
    ..b>CCR7 and Dicer 1 protein expression in 80 gastric adenocarcinomas and 40 peritumoral tissues were measured by ..
  55. doi Chemokine receptor CCR7 expression predicts poor outcome in uveal melanoma and relates to liver metastasis whereas expression of CXCR4 is not of clinical relevance
    Thierry Van den Bosch
    Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 54:7354-61. 2013
    To examine the prognostic relevance of expression of the chemokine receptors CCR7 and CXCR4 and its ligand CXCL12 in uveal melanoma in nonmetastatic and metastatic patients with correlation to liver metastasis and overall survival.
  56. ncbi Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2
    R Burgstahler
    Max Delbruck Centrum fur Molekulare Medizin, Berlin Buch, Germany
    Biochem Biophys Res Commun 215:737-43. 1995
    ..family of G-protein coupled chemokine receptors and turned out to be identical to the recently described receptor EBI1. Northern blot analysis revealed that BLR2 mRNA could be highly stimulated in mitogen- and anti-CD3-treated ..
  57. ncbi Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells
    H Hasegawa
    First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Blood 95:30-8. 2000
    ..cells from patients with and without lymphoid organ involvement for the expression of the chemokine receptor CCR7/EBI1, the functional receptor for secondary lymphoid-tissue chemokine (SLC), which is expressed at high levels by high ..
  58. ncbi In vivo differentiated cytokine-producing CD4(+) T cells express functional CCR7
    Gudrun F Debes
    Experimentelle Rheumatologie, Medizinische Klinik, Charite, Germany
    J Immunol 168:5441-7. 2002
    Chemokines and their receptors fulfill specialized roles in inflammation and under homeostatic conditions. CCR7 and its ligands, CCL19 and CCL21, are involved in lymphocyte recirculation through secondary lymphoid organs and additionally ..
  59. pmc Combinatorial guidance by CCR7 ligands for T lymphocytes migration in co-existing chemokine fields
    Saravanan Nandagopal
    Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 6:e18183. 2011
    ..In particular, a CCR7 ligand, CCL21, plays important roles in recruiting T cells to secondary lymphoid tissues (SLT)...
  60. pmc Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis
    Chao Yan
    Department of General Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    World J Gastroenterol 10:783-90. 2004
    To study the expression of vascular endothelial growth factor C (VEGF-C) and chemokine receptor CCR7 in gastric carcinoma and to investigate their associations with lymph node metastasis of gastric carcinoma and their values in predicting ..
  61. ncbi HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21
    Gamal Badr
    Institut National de la Sante et de la Recherche Medicale, Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 175:302-10. 2005
    ..Inhibition did not impair the expression or ligand-induced internalization of CCR6 and CCR7. Our data suggest that gp120/CXCR4 and gp120/CCR5 interactions lead to the cross-desensitization of CCR6 and CCR7 ..
  62. ncbi Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2
    V L Schweickart
    ICOS Corporation, Bothell, Washington 98021
    Genomics 23:643-50. 1994
    ..We have determined that this receptor, also reported as the Epstein-Barr-induced cDNA EBI1, is expressed in normal lymphoid tissues and in several B- and T-lymphocyte cell lines...
  63. ncbi Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells
    C H Kim
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 161:2580-5. 1998
    ..Macrophage-inflammatory protein (MIP)-3 beta/EBI1-ligand chemokine/CK beta-11 attracted bone marrow and cord blood CD34+ cells...
  64. ncbi Expression of the chemokine receptor CCR7 in prostate cancer presenting with generalized lymphadenopathy: report of a case, review of the literature, and analysis of chemokine receptor expression
    Gustavo A Heresi
    Department of Medicine, University of Miami School of Medicine, Miami, FL 33101, USA
    Urol Oncol 23:261-7. 2005
    ..Because of the association of chemokine receptor expression with specific metastatic patterns, we tested for expression of chemokine receptors known to mediate migration to lymph nodes...
  65. doi The chemokine receptor CXCR4 is more frequently expressed in breast compared to other metastatic adenocarcinomas in effusions
    Ben Davidson
    Pathology Clinic, Rikshospitalet Medical Center, Montebello, Oslo, Norway
    Breast J 14:476-82. 2008
    ..Breast carcinoma cells expressed CXCR4 in 7/21 (33%) effusions, with less frequent expression of CXCR1, CCR5, and CCR7. CXCR2 and CCR2 were absent...
  66. doi Chicken CCR6 and CCR7 are markers for immature and mature dendritic cells respectively
    Zhiguang Wu
    Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Dev Comp Immunol 35:563-7. 2011
    In mammals, the CC chemokine receptors 6 and 7 (CCR6 and CCR7) play important roles in controlling the trafficking of dendritic cells (DC)...
  67. ncbi Identification of naive or antigen-experienced human CD8(+) T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8(+) T cell response
    Mark R Wills
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Immunol 168:5455-64. 2002
    ..models of CD8(+) T cell memory, we found that in healthy virus carriers highly purified CD28(-)CD45RA(high)CCR7(-) cells are not terminally differentiated, because following stimulation in vitro with specific HCMV peptide these ..
  68. ncbi Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer
    Carl C Schimanski
    First Department of Internal Medicine and Institutes of Pathology and Surgery, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Clin Cancer Res 11:1743-50. 2005
    The expression of chemokine receptors CXCR4 and CCR7 has been associated with tumor dissemination and poor prognosis in a limited number of tumor entities...
  69. ncbi Involvement of chemokine receptor CCR6 in colorectal cancer metastasis
    Claudia Rubie
    Department of General, Visceral, Vascular and Pediatric Surgery, University of the Saarland, Homburg Saar, Germany
    Tumour Biol 27:166-74. 2006
    Various chemokine receptors, namely CXCR4, CCR6 and CCR7, have recently been shown to be involved in the regulation of metastasis in malignant tumors...
  70. ncbi Expression of growth factor and chemokine receptors: new insights in the biology of inflammatory breast cancer
    N Cabioglu
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Ann Oncol 18:1021-9. 2007
    Recent studies have indicated that expression of chemokine receptors CXCR4 and CCR7 could be an indicator of the metastatic potential of breast cancer...
  71. ncbi Expression of chemokine receptors CCR7 and CCR8 in the CNS during ChREAE
    B Bielecki
    Department of Experimental and Clinical Neurology, Medical University of Lodz, Lodz, Poland
    Scand J Immunol 66:383-92. 2007
    ..In this study, we analysed the expression of two recently identified CC chemokine receptors, CCR7 and CCR8, in the central nervous system (CNS) and in peripheral tissues during chronic relapsing experimental ..
  72. ncbi Expression of the CXCR4 and CCR7 chemokine receptors in human endometrial cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Eur J Gynaecol Oncol 28:370-5. 2007
    The chemokine receptors CXCR4 and CCR7 have been suggested to play an important role in cancer progression but their expression in human endometrial cancer has not been fully characterized...
  73. pmc Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis
    Yixin Liu
    Department of Pathology, Tianjin Medical University, Tianjin, China
    J Exp Clin Cancer Res 29:16. 2010
    The chemokine receptors CXCR4 and CCR7 play an important role in cancer invasion and metastasis...
  74. ncbi Synovial lymphoid neogenetic factors in Behçet's synovitis: do they play a role in self-limiting and subacute course of arthritis?
    S Pay
    Division of Rheumatology, Gulhane Military School of Medicine, Ankara, Turkey
    Clin Exp Rheumatol 25:S21-6. 2007
    ..21 homeostatic chemokines and the percentage of SF naive lymphocytes expressing their receptors such as CXCR4+ and CCR7+...
  75. ncbi Differentiation of CD8+ T cells from tumor-invaded and tumor-free lymph nodes of melanoma patients: role of common gamma-chain cytokines
    Andrea Anichini
    Human Tumor Immunobiology and Tumor Immunotherapy Units, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Immunol 171:2134-41. 2003
    ..n = 42) lymph nodes removed from the same nodal basin of melanoma patients were analyzed for the expression of CCR7, CD45RA, perforin, and granzyme B...
  76. ncbi [Impact of secondary lymphoid tissue chemokine on lymphocyte migration and the significance thereof in pathogenesis of ulcerative colitis: experiment with rats]
    Bu Jun Ge
    Department of Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China
    Zhonghua Yi Xue Za Zhi 88:3112-5. 2008
    ..To explore the impact of secondary lymphoid tissue chemokine (SLC) on lymphocyte migration and the significance thereof in the pathogenesis of ulcerative colitis (UC)...
  77. pmc Fully immunocompetent CD8+ T lymphocytes are present in autologous haematopoietic stem cell transplantation recipients despite an ineffectual T-helper response
    Alessandra Bandera
    Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milan Bicocca, Monza, Italy
    PLoS ONE 3:e3616. 2008
    ..Nevertheless, whereas opportunistic infections (OI) are frequent in HIV-infected individuals with low cell counts, OI are uncommon in ASCT patients...
  78. ncbi Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes
    Hanne S Hjorthaug
    Department of Immunology, Institute for Cancer Research, Rikshospitalet Radiumhopitalet Medical Center, and Department of Medical Genetics, Ulleval University Hospital, Oslo, Norway
    Eur J Immunol 37:2326-36. 2007
    ..Here, we show that a distinct population of CD8+ T lymphocytes, expressing the chemokine receptor CCR7, also binds ephrin-A1 and is stimulated to migrate after binding...
  79. doi CCR7+ myeloid dendritic cells together with CCR7+ T cells and CCR7+ macrophages invade CCL19+ nonnecrotic muscle fibers in inclusion body myositis
    Maki Tateyama
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    J Neurol Sci 279:47-52. 2009
    b>CCR7 and its ligands CCL19 and CCL21 are a key chemokine system in T cell priming in secondary lymphoid organs, and are rarely expressed in normal muscle tissue...
  80. doi In vitro maturation and migration of immature dendritic cells after chemokine receptor 7 transfection
    Hai Ming Xin
    Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China
    Can J Microbiol 55:859-66. 2009
    Dendritic cells are specialized antigen-presenting cells that regulate immunity and tolerance. Chemokine receptor 7 (CCR7), which is expressed by mature dendritic cells, mediates the migration of the cells to secondary lymphoid organs and ..
  81. pmc Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis
    Toshihiro Nanki
    Department of Medicine, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Arthritis Res Ther 11:R149. 2009
    ..The aims of this study were to determine chemokine receptor expression by B cells both in the peripheral blood of normal donors and subjects with RA, and at the inflammatory site in RA, and the effects of chemokines on B cell activation...
  82. ncbi Impact of CCR7 on priming and distribution of antiviral effector and memory CTL
    Tobias Junt
    Institute of Experimental Immunology, Zurich, Switzerland
    J Immunol 173:6684-93. 2004
    The chemokine receptor CCR7 is a key factor in the coordinate migration of T cells and dendritic cells (DC) into and their localization within secondary lymphoid organs...
  83. doi CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens
    Ariel H Achtman
    Molecular Tumor Genetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
    J Leukoc Biol 85:409-17. 2009
    ..Surprisingly, immunization of mice deficient for the homeostatic chemokine receptor CCR7 with TI-2 antigens resulted not only in the expected, vigorous extrafollicular plasma cell response but also in ..
  84. pmc CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus
    Daniel A Zlotoff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Blood 115:1897-905. 2010
    ..Here we report that the chemokine receptor CCR7 is also required for efficient thymic settling...
  85. pmc Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    J Exp Med 197:1191-8. 2003
    ..Using CXCL13-/- mice that additionally carry the paucity of LN T cell mutation (plt/plt), we discovered that CCR7 ligands function in peripheral LN development...
  86. ncbi Characterization of effusion-infiltrating T cells: benign versus malignant effusions
    Djordje Atanackovic
    Oncology Hematology, Department of Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Cancer Res 10:2600-8. 2004
    ..We analyzed whether deficient numbers of effector-type T cells within the malignant effusion might contribute to tumor escape from immunosurveillance...
  87. pmc The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking
    Yiping Jin
    Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 13:626-34. 2007
    ..However, very little is known about the molecular regulation of this pathway. We investigated the expression and function of the chemokine receptor CCR7 in mediating corneal APC migration in inflammation.
  88. ncbi Peripheral blood dendritic cells in human end-stage heart failure and the early post-transplant period: evidence for systemic Th1 immune responses
    Petros Athanassopoulos
    Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands
    Eur J Cardiothorac Surg 25:619-26. 2004
    ..In this study we examined total peripheral blood DCs, mDC and pDC subsets in chronic heart failure (CHF) and clinical heart transplantation (HTx)...
  89. ncbi Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7
    Trudy A Kohout
    Department of Exploratory Discovery, Neurocrine Biosciences Inc, San Diego, California 92121, USA
    J Biol Chem 279:23214-22. 2004
    ..In this study we investigated the early signaling events of CCR7 initiated by its two endogenous ligands, CCL19 and CCL21...
  90. ncbi Regulation of T-lymphocyte trafficking by ICAM-1, MAdCAM-1, and CCR7 in microcirculation of appendicular and intestinal lymphoid tissues
    Hideyasu Nagamatsu
    Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    Microcirculation 11:493-502. 2004
    ..The authors investigated if there are specific features in T-lymphocyte adhesion to microvessels of the appendix compared to mouse Peyer's patches (PPs)...
  91. ncbi Endotoxin upregulates CCR7 and its ligands in the lymphatic-free mouse iris
    F Mackensen
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Mol Vis 13:2209-13. 2007
    ..tissues migrate to lymph nodes in response to chemokines, CCL19 (ELC) and CCL21b (SLC), that activate the CCR7 receptor...
  92. doi Increased transplant arteriosclerosis in the absence of CCR7 is associated with reduced expression of Foxp3
    Stephan M Ensminger
    Department of Cardiac Surgery, Friedrich Alexander University Erlangen Nuernberg, Germany
    Transplantation 86:590-600. 2008
    The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs and the migration of dendritic cells into afferent lymphatic vessels...
  93. doi Genetic co-transfer of CCR7 ligands enhances immunity and prolongs survival against virulent challenge of pseudorabies virus
    Young Woo Han
    Department of Microbiology, College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju, Republic of Korea
    Immunol Cell Biol 87:91-9. 2009
    The CC chemokine receptor 7 (CCR7) and cognate CCR7 ligands, CCL19 and CCL21, help establish microenvironments in lymphoid tissue that can facilitate encounters between naive T cells and mature dendritic cells (DCs)...
  94. doi Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype
    Amine Issa
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Cancer Res 69:349-57. 2009
    ..there is growing evidence implicating lymphatic-homing chemokine receptors, particularly C-C chemokine receptor 7 (CCR7), in lymph node metastasis...
  95. pmc Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation
    B Fevang
    Research Institute for Internal Medicine, Rikshospitalet University Hospital and University of Oslo, Oslo, Norway
    Clin Exp Immunol 158:237-45. 2009
    ..The homeostatic chemokines CCL19 and CCL21 and their receptor CCR7 are associated with modulation of inflammatory responses...
  96. pmc Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation
    Yiping Jin
    Schepens Eye Research Institute and the Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 51:816-21. 2010
    Chemokine receptor 7 (CCR7) is a key homing molecule for immune cell trafficking, including corneal antigen-presenting cell (APC) migration from the inflamed cornea to draining lymph nodes (LNs)...
  97. ncbi CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells
    C H Kim
    Department of Microbiology Immunology, The Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 160:2418-24. 1998
    ..beta-11/MIP-3 beta/ELC, a recently reported CC chemokine that specifically binds to a chemokine receptor, EBI1/BLR2/CCR7. CK beta-11/MIP-3 beta/ELC is distantly related to other CC and CXC chemokines in primary amino acid sequence ..
  98. ncbi Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin
    Fuminori Katou
    Department of Oral and Maxillofacial Surgery I, Tohoku University School of Dentistry, Sendai, Japan
    J Pathol 199:98-106. 2003
    ..further in chronically inflamed skin and LNs, the present study focuses on another chemokine system, namely CCL19 (EBI1 ligand chemokine; ELC), CCL21 (secondary lymphoid tissue chemokine; SLC) and their shared receptor, CCR7...
  99. pmc CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection
    Gudrun F Debes
    Experomentelle Rheumatologie Medizinische Klinik, Charite, Humboldt Universitat, Germany
    J Virol 78:7528-35. 2004
    ..We found high levels of l-selectin and CC chemokine receptor 7 (CCR7) expression in lung-derived CD4(+) T cells, similar to that detected on T cells in secondary ..
  100. pmc Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice
    Eugene Trogan
    Marc and Ruti Bell Vascular Biology Program, Leon H Charney Division of Cardiology Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:3781-6. 2006
    ..or apoE-/- recipient samples, but there was induction at the mRNA and protein levels of chemokine receptor CCR7, an essential factor for dendritic cell migration...
  101. ncbi Detailed analysis of intrahepatic CD8 T cells in the normal and hepatitis C-infected liver reveals differences in specific populations of memory cells with distinct homing phenotypes
    Mathis Heydtmann
    Liver Research Laboratories, Medical Research Council, Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    J Immunol 177:729-38. 2006
    ..Current models divide primed CD8 T cells into effector and memory cells, further subdivided into central memory (CCR7+, L-selectin+), recirculating through lymphoid tissues and effector memory (CCR7-, L-selectin-) mediating immune ..

Research Grants62

  1. MICHAEL LORAN DUSTIN; Fiscal Year: 2014
    ..Chemokine receptors are a major class of G-protein coupled receptors and CCR7 is the most important member of this class of receptors for delivering GO signals to naive effector T cells (Teff) ..
  2. Joel D Ernst; Fiscal Year: 2016
    ..lymph node for initiation of the adaptive immune response, we will test the hypothesis that the chemokine receptors CCR7 and CCR8 mediate migration of mature DCs from the lungs to the mediastinal lymph node...
  3. Frances E Lund; Fiscal Year: 2016
    ..The proposed approach is conceptually innovative in that we are moving beyond the current CCR7-centric paradigm to test how different microdomains in the LN program DCs to initiate Th2 priming...
  4. Steven M Dubinett; Fiscal Year: 2016
    ..CCL21 binds to the chemokine receptor CCR7 and is chemoattractant for mature DCs, naive and memory T cells...
  5. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..evidence that Id3 regulates B cell expression of specific chemokines: CXCR4, CXCR7, and CCR6 but not CXCR5 or CCR7 (chemokine receptors known to regulate B cell homing to lymphoid tissue), providing a potential mechanism whereby ..
  6. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..receptors that facilitate tumor chemotaxis, CXC chemokine receptor type 4 (CXCR4) and CC chemokine receptor type 7 (CCR7)...
  7. Role and Regulation of CCR7 in Regression of Atherosclerotic Lesions
    Jonathan E Feig; Fiscal Year: 2010
    ..We showed that CCR7, an established maturation marker for dendritic cells that promotes their emigration from tissues to lymph nodes, ..
  8. Fadi G Lakkis; Fiscal Year: 2016
    ..vascularized cardiac allografts during chronic inflammation - we will examine the roles of the chemokine receptor CCR7 and the adhesion molecule L-selectin (CD62L) expressed on memory T cells...
  9. Treg Migration in GVHD
    Jonathan Serody; Fiscal Year: 2009
    ..The following three specific aims will be evaluated: Aim 1): To evaluate the function of L-selectin, CCR5 and CCR7 in the migration of Treg cells into secondary lymphoid organs...
  10. Engineering hematopoietic progenitors for efficient migration to the thymus
    Avinash Bhandoola; Fiscal Year: 2010
    ..More specifically, we hypothesize that the chemokine receptors CCR7 and CCR9 cooperate to mediate recruitment of rare BM- derived progenitors to the thymus...
  11. The role of chemokines in the establishment of HIV latency
    SHARON RUTH LEWIN; Fiscal Year: 2012
    ..These include CXCR3, CCR6 and CCR7. The chemokine receptor and chemokine antagonists will be evaluated alone and in combination in vitro...
  12. Genetic Analy. of Chemokine Receptors in T Cell Develop.
    Lishan Su; Fiscal Year: 2003
    ..Multiple chemokines (SDF-1, TECK, MDC, IP-10, and ELC) and corresponding CKR (CXCR4, CCR9, CCR4, CXCR3 and CCR7) are expressed in the thymus...
  13. The Role of Mast Cells in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2006
    ..membrane within 1 h of IgE-dependent activation, while strong de novo steady-state expression of mRNA encoding CCR7 is induced by 6 h...
  14. Environmental Control of the Immunological Synapse
    Michael Dustin; Fiscal Year: 2003
    ..that this stop signal can be reversed by gradients of chemokines interacting with dominant chemokine receptors CCR7 and CXCR3, but not by chemokine gradients interacting with subordinate chemokine receptors CCR5 and CXCR4...
  15. Novel Immune Pathways for Lung Cancer Therapy
    Sherven Sharma; Fiscal Year: 2012
    ..Based on our data in the laboratory we note that while small tumors (5-7 day old) are highly responsive to CCR7 ligand therapy, larger tumors (>10 day old) progress despite therapy...
  16. Antibody Neutralization of Therapeutic Viruses
    Stephen J Russell; Fiscal Year: 2012
    ..Aim 3. Determine whether suppression of CCR7 chemokine receptor expression can favorably impact the biodistribution of measles-infected dendritic cells in CD46 ..
  17. The role of chemokines in experimental thyroiditis
    Sergio A Lira; Fiscal Year: 2012
    ..Deletion of CCR7, the receptor for CCL21, in the autoimmune-prone NOD background favors development of thyroiditis, suggesting a ..
  18. JAMES M COGHILL; Fiscal Year: 2015
    ..animal model data showing that donor cells lacking the lymph node trafficking receptor CC-Chemokine receptor 7 (CCR7) generate greatly attenuated GVHD responses when transplanted into recipient mice...
  19. JONATHAN STUART SERODY; Fiscal Year: 2015
    ..We have found that the chemokine receptor, CCR7, expressed by donor T cells is critically important for the migration of donor T cells to lymph nodes and the ..
  20. Testing in vivo of HIV-immunopathogenic hypotheses using new kinetic techniques
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2012
    ..The markers tested so far (e.g., CCR7, CD28) have revealed only modest differences in turnover...
  21. Richard M Pope; Fiscal Year: 2014
    ..Our preliminary data demonstrate that CCR7 is expressed by RA synovial tissue macrophages...
  22. Role of chemokines in diabetes
    Sergio A Lira; Fiscal Year: 2013
    ..autoantigens produced during the initial inflammatory process into the peripancreactic lymph nodes is dependent on CCR7. We also hypothesize that trafficking of naove autoreactive T cells into the peripancreactic lymph nodes is ..
  23. Kathryn J Moore; Fiscal Year: 2016
    ..of CD68+ cells reflected their emigration to lymph nodes, and required the upregulation of their chemokine receptor CCR7, a known migratory factor in monocyte-derived cells...
  24. Chemokine Receptor CCR7 In Tissue-Specific T Cell Imprinting and Autoimmunity
    James J Campbell; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chemokine receptor CCR7 is a key regulator of both the initiation and anamnestic phases of T cell mediated immune responses...
  25. Asthma Induction by Dendritic Cells and Th2 Cells
    Sun Sang Sung; Fiscal Year: 2007
    ..The aims consist of: (1) the isolation and functional studies of DC subsets in lungs; (2) the studies of CCR7/SLC interaction as a key chemokine receptor/chemokine interaction for lung DC and T cell migration to lymph nodes...
  26. ROLE OF EXODUS-2/SLC/6CKINE IN GVHD
    Robert Hromas; Fiscal Year: 2004
    ..Exodus-2 and 3 are both ligands for the CC chemokine CCR7. These CCR7 chemokines are distantly related to other chemokines (twenty-eight percent homology with MIP-1a) but ..
  27. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..3 we have recently identified an exciting new molecular target that allows for the pharmacological inhibition of CCR7- effector memory T (TEM) cells. Expression of Kv1.3 is increased in both CD4+ and CD8+ TEM cells and Kv1...
  28. Naltrexone and AIDS progression
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
    ..cells will be determined by a polychromatic flow cytometry panel that includes antibodies to CD3, CD4, CD28, CD95, CCR7, CCR5, CD69, HLA-DR and PD-1, and monitored every 2 weeks...
  29. Aric L Gregson; Fiscal Year: 2015
    ..The frequencies of BAL Treg correlated with BAL levels of the CCR7 ligand CCL21, which itself appears to protect against BOS...
  30. T Cell Immunity in Endemic Burkitt Lymphoma
    Ann M Moormann; Fiscal Year: 2012
    ..will be quantified using HLA Class I tetramers and T cell subsets defined as central memory, TCM (CD45RA-CD62L+CCR7+);effector memory, TEM (CD45RA-CD62L- CCR7-);and RA re-expressing effector memory, TEMRA (CD45RA+CD62L-CCR7-)...
  31. Iannis Aifantis; Fiscal Year: 2015
    ..Here, we show using T-ALL animal modeling and gene-expression profiling that the chemokine receptor CCR7 is the essential adhesion signal required for the targeting of leukemic T-cells into the CNS...
  32. Treg Migration in GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2011
    ..unreadable] We will investigate the mechanism by which CCR7 -/- Treg cells given with allogeneic bone marrow and T cells mediate cGvHD focusing on the role of donor and host T ..
  33. Development of CMV-specific T Cell Memory in Lung Transplant Recipients
    John F McDyer; Fiscal Year: 2012
    ..Because we unexpectedly detect CMV-specific CCR7+ TCM cells in human and murine lung airways during active infection, we will determine the relationship between TCM ..
  34. RACHAEL ANN CLARK; Fiscal Year: 2016
    ..Leukemic cutaneous T cell lymphoma (L-CTCL) is a non-Hodgkins lymphoma derived from skin tropic L-selectin/CCR7+ central memory T cells (TCM)...
  35. Targeting T lymphocyte potassium channels for the treatment of asthma--OLD
    Christine Beeton; Fiscal Year: 2010
    ..New therapeutic targets for asthma would therefore have tremendous benefits for public health. CCR7- effector memory conventional T (cTEM) lymphocytes play a major role in autoimmune diseases and in asthma...
  36. CD8 T Cells in Rheumatoid Arthritis
    Cornelia M Weyand; Fiscal Year: 2013
    ..through IL-15 combined with low-affinity T cell receptor stimulation;they express a unique phenotype;CD8+CD45RA+CCR7+ and function by disrupting membrane-proximal signaling events in CD4 T cells...
  37. Regulation of T cell egress from inflamed skin
    GUDRUN PHILOMENA DEBES; Fiscal Year: 2013
    ..from peripheral tissue is regulated and that CD4 and CD8 T cells require the expression of the chemokine receptor CCR7 for exit under non-inflammatory conditions...
  38. Sherven Sharma; Fiscal Year: 2014
    ..Hypothesis 1: Depleting CXCR3 and CCR7 receptor expressing effector cells [immune (CD4 T and CD8 T) and innate (NK and NKT)] will reduce CCL21-SC mediated ..
  39. Development of T cell memory in human Trypanosoma cruzi infection
    Susana Laucella; Fiscal Year: 2013
    ..effector memory profile of the overall T cell compartment will be examined by the expression of CD62L and CCR7. Antibody titers to recombinant parasite proteins will be quantified by Bioplex assays...
  40. Recruitment of hematopoietic progenitors in the thymus
    DANIEL ZLOTOFF; Fiscal Year: 2012
    ..We have preliminary evidence that the chemokine receptor CCR7 additionally supports thymic settling...
  41. LILIANNA SOLNICAKREZEL; Fiscal Year: 2015
    ..In Aim 2, we will test the hypothesis that Ccr7 chemokine GPCR regulates axis formation by inhibiting [unreadable]-catenin in a GSK3[unreadable] independent and a ..
  42. MANISH PRAKASH PONDA; Fiscal Year: 2014
    ..disease prevents the regression of atherosclerosis 2) the impairment is a result of defective chemokine receptor 7 (CCR7) signaling...
  43. Vein Wall Fibrotic Injury After DVT is SLC-CCR7 Dependent
    Peter K Henke; Fiscal Year: 2012
    ..The chemokine SLC (CCL21) and its primary receptor, CCR7, have been shown to be integral in both human and experimental fibrotic organ injury...
  44. Mark I Greene; Fiscal Year: 2014
    ..We have previously shown that normal migration of progenitors to the thymus uses two homing molecules, CCR7 and CCR9...
  45. TNT: Targeting and Triggering Adjuvancy of DNA Vaccines
    Michele Kutzler; Fiscal Year: 2005
    ..staining (intracellular stains for IFN-g and TNF-a, and surface staining for the T cell markers CD45RO, CD27, CCR7, CCR5, and MHC Class I and II Tetramers)...
  46. Molecular Pathobiology of Langerhans Cell Histiocytosis
    Barrett Rollins; Fiscal Year: 2007
    ..Once LCs ingest antigen and are activated, they down-regulate CCR6 and up-regulate CCR7. This attracts LCs to lymph nodes, the source of CCR7's ligands, where they present antigen to T cells...
  47. Molecular Pathobiology of Langerhans Cell Histiocytosis
    Barrett Rollins; Fiscal Year: 2002
    ..Once LC's ingest antigen and become activated, they down- regulate CCR6 and up-regulate CCR7. This attracts LC's to lymph nodes, the source of CCR7's ligands, where they present antigen to T cells...
  48. Chemokines and their Receptors in Anthrax Infection
    Wendy Peters; Fiscal Year: 2004
    ..DCs use another chemokine receptor CCR7 to traffic to draining lymph nodes (DLNs)...
  49. T CELL DEPENDENT TERMINAL MATURATION OF LANGERHANS CELLS
    Akira Takashima; Fiscal Year: 2005
    ..To test the second hypothesis that efficacy of DC vaccines can be improved by promoting DC homing, CCR7 DNA-transfected "bullet" DC will be examined for their homing property and the ability to induce anti-tumor ..
  50. Dendritic Cell Migration and Function in the Pregnant and Non-pregnant Uterus
    Mary Collins; Fiscal Year: 2009
    ..regulate directional DC migration within peripheral tissues other than the involvement of the chemokine receptor CCR7, which is expressed by activated DCs, and its ligand CCL21, which is expressed by lymphatic vessels...
  51. The Role of Arrestins in CCR7 Trafficking
    CHARLOTTE VINES; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The G-protein coupled chemokine receptor (GPCR), CCR7 plays an essential role in delayed type hypersensitivity mediated by CD4+ T lymphocytes...
  52. Chemokine System in DC and Lymphocyte Function
    SEEMA AHUJA; Fiscal Year: 2005
    ..Over the last two years, significant attention has been focused on CC chemokine receptor 6 (CCR6), CCR7, and CXCR5 and their ligands in DC, and T- and B-cell function, and lymphoid organ homeostasis...
  53. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2007
    ..Our work demonstrate that tumor PDC induce TAA-specific IL-10+CCR7+CD8+ T cells...
  54. Chemokine Signals in Head and Neck Cancer Progression
    Robert L Ferris; Fiscal Year: 2010
    ..chemokine receptor (CCR)7 that may facilitate lymph node metastasis, and we have shown upregulation of functional CCR7 on metastatic squamous cell carcinoma of the head and neck (SCCHN), compared to nonmetastatic tumors...
  55. Neural precursor cell therapy for disseminated glioma
    Reid Thompson; Fiscal Year: 2009
    ..chemokine ligands (CXCL1, CXCL8, CXCL12, and CCL21) and their corresponding receptors (CXCR1, CXCR2, CXCR4, and CCR7) in governing the migratory capacity of NPC...
  56. Kv1.3 channels: functional biomarker and therapeutic target for Type-1 Diabetes
    George Chandy; Fiscal Year: 2007
    ..3 potassium channel and are CCR7-CD45RA- effector memory (TEM) T cells. We have developed highly specific Kv1...
  57. Kv1.3 channels: functional biomarker and therapeutic target for Type-1 Diabetes
    George Chandy; Fiscal Year: 2006
    ..3 potassium channel and are CCR7-CD45RA- effector memory (TEM) T cells. We have developed highly specific Kv1...
  58. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2007
    ..Key trafficking molecules to be studied include CD62L, beta7integrin, CCR7, and CXCR3. We will determine whether deficiencies in these molecules prevent GVHD...
  59. Allograft Homing and Function of Regulatory T Cells Post-Transplant
    Wayne Hancock; Fiscal Year: 2007
    Aim 1: Test whether the CCR7 pathway has a key role in determining the development of host alloresponses...
  60. Lymphocyte Exit from Tissues: Control and Significance to Host Defense
    GUDRUN DEBES; Fiscal Year: 2009
    ..peripheral tissues via the afferent lymph is a regulated and active process, and that T cells require expression of CCR7 to do so...
  61. The role of the chemokine receptos CCR4 and CCR7 in graft-versus-host disease
    James Coghill; Fiscal Year: 2009
    ..The principal goal of this project will be to examine the role of the chemokine receptors CCR4 and CCR7 in the migration of Treg cells during GVHD...
  62. Nonpeptide Antagonists of CCR-7 for Immunosuppression
    David Alleva; Fiscal Year: 2002
    ..lymphoid organs, and attracts T cells and mature DC (DC that have processed antigen) that express CC chemokine receptor 7 (CCR7), the G-protein coupled receptor (GPCR) for these two chemokines...