CD45

Summary

Gene Symbol: CD45
Description: protein tyrosine phosphatase, receptor type C
Alias: B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, receptor-type tyrosine-protein phosphatase C, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide
Species: human
Products:     CD45

Top Publications

  1. Jacobsen M, Schweer D, Ziegler A, Gaber R, Schock S, Schwinzer R, et al. A point mutation in PTPRC is associated with the development of multiple sclerosis. Nat Genet. 2000;26:495-9 pubmed
    ..role of a point mutation in the gene (PTPRC) encoding protein-tyrosine phosphatase, receptor-type C (also known as CD45) in the heterozygous state in the development of MS...
  2. Vogel A, Strassburg C, Manns M. 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link. Genes Immun. 2003;4:79-81 pubmed
    ..Here we analyzed the genetic association of the tyrosine phosphatase CD45 and autoimmune hepatitis...
  3. Amano M, Galvan M, He J, Baum L. The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. J Biol Chem. 2003;278:7469-75 pubmed
    ..Expression of the ST6Gal I specifically resulted in increased sialylation of N-glycans on CD45, a receptor tyrosine phosphatase that is a T cell receptor for galectin-1...
  4. Blanchetot C, Tertoolen L, Overvoorde J, den Hertog J. Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. J Biol Chem. 2002;277:47263-9 pubmed
    ..Seven RPTPs from four different subfamilies were used: RPTPalpha, RPTPepsilon, LAR, RPTPvarsigma, RPTPdelta, CD45, and RPTP(mu). We found that RPTP-D2s bound to RPTPs with different affinities...
  5. Baldwin T, Ostergaard H. Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45. J Immunol. 2001;167:3829-35 pubmed
    Glucosidase II (GII) stably interacts with the external domain of CD45 in a carbohydrate-dependent manner. We have found that the association occurs in immature cells, but is significantly reduced in mature T cells...
  6. Wang Y, Guo W, Liang L, Esselman W. Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis. J Biol Chem. 1999;274:7454-61 pubmed
    b>CD45 is a receptor-type protein-tyrosine phosphatase (PTP) that is required for antigen-specific stimulation and proliferation in lymphocytes...
  7. Mustelin T, Williams S, Tailor P, Couture C, Zenner G, Burn P, et al. Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase. Eur J Immunol. 1995;25:942-6 pubmed
    ..In addition, the CD45 phosphotyrosine phosphatase (PTPase) is required for the induction of tyrosine phosphorylation by the TcR/CD3, ..
  8. Felberg J, Lefebvre D, Lam M, Wang Y, Ng D, Birkenhead D, et al. Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation. J Biol Chem. 2004;279:3455-62 pubmed
    b>CD45 is a transmembrane, two-domain protein-tyrosine phosphatase expressed exclusively in nucleated hematopoietic cells...
  9. Tchilian E, Wallace D, Wells R, Flower D, Morgan G, Beverley P. A deletion in the gene encoding the CD45 antigen in a patient with SCID. J Immunol. 2001;166:1308-13 pubmed
    ..investigated the first SCID patient to be described with minimal cell surface expression of the leukocyte common (CD45) Ag...
  10. Furukawa T, Itoh M, Krueger N, Streuli M, Saito H. Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain. Proc Natl Acad Sci U S A. 1994;91:10928-32 pubmed
    The CD45 transmembrane protein-tyrosine phosphatase (PTPase, EC 3.1.3.48) plays an essential role in T-cell activation by activating the Lck and/or Fyn protein-tyrosine kinases...

Detail Information

Publications62

  1. Jacobsen M, Schweer D, Ziegler A, Gaber R, Schock S, Schwinzer R, et al. A point mutation in PTPRC is associated with the development of multiple sclerosis. Nat Genet. 2000;26:495-9 pubmed
    ..role of a point mutation in the gene (PTPRC) encoding protein-tyrosine phosphatase, receptor-type C (also known as CD45) in the heterozygous state in the development of MS...
  2. Vogel A, Strassburg C, Manns M. 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link. Genes Immun. 2003;4:79-81 pubmed
    ..Here we analyzed the genetic association of the tyrosine phosphatase CD45 and autoimmune hepatitis...
  3. Amano M, Galvan M, He J, Baum L. The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. J Biol Chem. 2003;278:7469-75 pubmed
    ..Expression of the ST6Gal I specifically resulted in increased sialylation of N-glycans on CD45, a receptor tyrosine phosphatase that is a T cell receptor for galectin-1...
  4. Blanchetot C, Tertoolen L, Overvoorde J, den Hertog J. Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. J Biol Chem. 2002;277:47263-9 pubmed
    ..Seven RPTPs from four different subfamilies were used: RPTPalpha, RPTPepsilon, LAR, RPTPvarsigma, RPTPdelta, CD45, and RPTP(mu). We found that RPTP-D2s bound to RPTPs with different affinities...
  5. Baldwin T, Ostergaard H. Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45. J Immunol. 2001;167:3829-35 pubmed
    Glucosidase II (GII) stably interacts with the external domain of CD45 in a carbohydrate-dependent manner. We have found that the association occurs in immature cells, but is significantly reduced in mature T cells...
  6. Wang Y, Guo W, Liang L, Esselman W. Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis. J Biol Chem. 1999;274:7454-61 pubmed
    b>CD45 is a receptor-type protein-tyrosine phosphatase (PTP) that is required for antigen-specific stimulation and proliferation in lymphocytes...
  7. Mustelin T, Williams S, Tailor P, Couture C, Zenner G, Burn P, et al. Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase. Eur J Immunol. 1995;25:942-6 pubmed
    ..In addition, the CD45 phosphotyrosine phosphatase (PTPase) is required for the induction of tyrosine phosphorylation by the TcR/CD3, ..
  8. Felberg J, Lefebvre D, Lam M, Wang Y, Ng D, Birkenhead D, et al. Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation. J Biol Chem. 2004;279:3455-62 pubmed
    b>CD45 is a transmembrane, two-domain protein-tyrosine phosphatase expressed exclusively in nucleated hematopoietic cells...
  9. Tchilian E, Wallace D, Wells R, Flower D, Morgan G, Beverley P. A deletion in the gene encoding the CD45 antigen in a patient with SCID. J Immunol. 2001;166:1308-13 pubmed
    ..investigated the first SCID patient to be described with minimal cell surface expression of the leukocyte common (CD45) Ag...
  10. Furukawa T, Itoh M, Krueger N, Streuli M, Saito H. Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain. Proc Natl Acad Sci U S A. 1994;91:10928-32 pubmed
    The CD45 transmembrane protein-tyrosine phosphatase (PTPase, EC 3.1.3.48) plays an essential role in T-cell activation by activating the Lck and/or Fyn protein-tyrosine kinases...
  11. Tonks N, Charbonneau H, Diltz C, Fischer E, Walsh K. Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase. Biochemistry. 1988;27:8695-701 pubmed
    It has been proposed on the basis of amino acid sequence homology that the leukocyte common antigen CD45 represents a family of catalytically active, receptor-linked protein tyrosine phosphatases [Charbonneau, H., Tonks, N. K., Walsh, K...
  12. Carrasco Yepez M, Campos Rodríguez R, Reséndiz Albor A, Peña Juárez C, Contis Montes de Oca A, Arciniega Martínez I, et al. Naegleria fowleri immunization modifies lymphocytes and APC of nasal mucosa. Parasite Immunol. 2017;: pubmed publisher
    ..In all immunized groups, the percentage of CD4 was higher than CD8 cells. CD45 was increased in B cells from mice immunized...
  13. Nobile Orazio E, Bianco M, Nozza A. Advances in the Treatment of Paraproteinemic Neuropathy. Curr Treat Options Neurol. 2017;19:43 pubmed publisher
    ..In most instances, however, their efficacy needs to be confirmed in controlled trials...
  14. Jaberolansar N, Chappell K, Watterson D, Bermingham I, Toth I, Young P, et al. Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein. Sci Rep. 2017;7:11130 pubmed publisher
    ..These results provide a note of caution in assuming that peptide vaccines, successfully designed to structurally mimic minimal linear B cell epitopes, will necessarily elicit the desired immune response. ..
  15. Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, et al. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc Natl Acad Sci U S A. 1990;87:7000-4 pubmed
    ..lambda gt11 was screened under conditions of reduced hybridization stringency with a leukocyte common antigen (LCA) probe that spanned both conserved cytoplasmic domains...
  16. Golstein P, Boom A, van Geffel J, Jacobs P, Masereel B, Beauwens R. P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999;437:652-60 pubmed
    ....
  17. Teplyakov A, Obmolova G, Malia T, Gilliland G. Crystal structure of CD27 in complex with a neutralizing noncompeting antibody. Acta Crystallogr F Struct Biol Commun. 2017;73:294-299 pubmed publisher
    ..This mode of action suggests a potential dual use of mAb 2177 either as an antagonist or as an agonist...
  18. Pradhan D, Morrow J. The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production. Immunity. 2002;17:303-15 pubmed
    With T cell receptor stimulation, intracellular pools of CD45 and spectrin move to the surface. These processes are coupled. In both peripheral lymphocytes and Jurkat T cells, betaI spectrin and ankyrin associate with CD45...
  19. Sciskalska M, Marek G, Grzebieniak Z, Milnerowicz H. Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics. Mediators Inflamm. 2017;2017:3039765 pubmed publisher
    ..Endothelin-1 (ET-1) and resistin concentrations, markers of endothelium injury, were determined...
  20. Andrade A, Van Nistelrooy J, Peery R, Skatrud P, De Waard M. The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production. Mol Gen Genet. 2000;263:966-77 pubmed
    ..These results suggest that ABC transporters may be involved in secretion of penicillin from fungal cells...
  21. Dunne C, McDermot A, Anjan K, Ryan A, Reid C, Clyne M. Use of Recombinant Mucin Glycoprotein to Assess the Interaction of the Gastric Pathogen Helicobacter pylori with the Secreted Human Mucin MUC5AC. Bioengineering (Basel). 2017;4: pubmed publisher
    ..This study demonstrates the feasibility of using recombinant mucins containing tandem repeat sequences to assess microbial mucin interactions. ..
  22. Lee J, Nyenhuis D, Nelson E, Cafiso D, White J, Tamm L. Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity. Proc Natl Acad Sci U S A. 2017;114:E7987-E7996 pubmed publisher
    ..Mutation of aromatic and neighboring residues in both binding partners decreases fusion and viral entry, highlighting the functional importance of the MPER/TM-FL interaction in EBOV entry and fusion. ..
  23. Kruglova N, Meshkova T, Kopylov A, Mazurov D, Filatov A. Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP). PLoS ONE. 2017;12:e0182468 pubmed publisher
    ..LPAP is a component of a supramolecular complex composed of the phosphatase CD45, the co-receptor CD4, and the kinase Lck...
  24. Ernst R, Kueppers P, Klein C, Schwarzmueller T, Kuchler K, Schmitt L. A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5. Proc Natl Acad Sci U S A. 2008;105:5069-74 pubmed publisher
    ..Taken together, our data provide important insights into the molecular mechanism of Pdr5 and suggest that not solely the transmembrane domains dictate substrate selection...
  25. Xu Y, Xiao X, Li S, Jia X, Xin W, Wang P, et al. Molecular genetics of Leber congenital amaurosis in Chinese: New data from 66 probands and mutation overview of 159 probands. Exp Eye Res. 2016;149:93-99 pubmed publisher
    Leber congenital amaurosis (LCA) is the most severe form of inherited retinal dystrophy. We have previously performed a mutational analysis of the known LCA-associated genes in probands with LCA by both Sanger and whole exome sequencing...
  26. Gardner T, Tortorella D. Virion Glycoprotein-Mediated Immune Evasion by Human Cytomegalovirus: a Sticky Virus Makes a Slick Getaway. Microbiol Mol Biol Rev. 2016;80:663-77 pubmed publisher
    ....
  27. Mercier F, Sykes D, Scadden D. Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports. 2016;6:985-92 pubmed publisher
    ..specifically recognize hematopoietic cells from congenic mouse strains due to variants of the cell surface protein CD45, designated CD45.1 and CD45.2. The current congenic competitor strain, B6.SJL-Ptprc(a) Pepc(b)/BoyJ (CD45...
  28. Qian X, Jin Y, Chen H, Xu Q, Ren H, Zhu S, et al. Trachelogenin, a novel inhibitor of hepatitis C virus entry through CD81. J Gen Virol. 2016;97:1134-44 pubmed publisher
    ..Therefore, TGN is a potential candidate for future cocktail therapies to treat HCV-infected patients...
  29. Inouye H, Kirschner D. Evolution of myelin ultrastructure and the major structural myelin proteins. Brain Res. 2016;1641:43-63 pubmed publisher
    ..This article is part of a Special Issue entitled SI: Myelin Evolution...
  30. Takeuchi R, Shinozaki K, Nakanishi T, Tamai I. Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart. Drug Metab Dispos. 2016;44:68-74 pubmed publisher
    ..In other words, the tissue distribution of drugs can be influenced by drug-drug interaction (DDI) at efflux transporters in certain tissues (local DDI) without any apparent change in plasma concentration (systemic DDI). ..
  31. Wang Z, Wong I, Li F, Yang C, Liu Z, Jiang T, et al. Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors. Bioorg Med Chem. 2015;23:5566-73 pubmed publisher
    ..0). In summary, our study demonstrates that permethyl ningalin B derivative 12 is non-toxic and efficient P-gp inhibitor that is a potential candidate to be used clinically to reverse P-gp mediated cancer drug resistance...
  32. Morgeaux S, Poirier B, Ragan C, WILKINSON D, Arabin U, Guinet Morlot F, et al. Replacement of in vivo human rabies vaccine potency testing by in vitro glycoprotein quantification using ELISA - Results of an international collaborative study. Vaccine. 2017;35:966-971 pubmed publisher
    ..One of the ELISA designs was proposed to the European Directorate for the Quality of Medicines & HealthCare (EDQM) and accepted for an international collaborative study under the umbrella of the Biological Standardisation Programme...
  33. Patel S, Leibrand C, Palasuberniam P, Couraud P, Weksler B, Jahr F, et al. Effects of HIV-1 Tat and Methamphetamine on Blood-Brain Barrier Integrity and Function In Vitro. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Tat and methamphetamine may also affect several aspects of transcellular transport. ..
  34. Schumacher K, Dodds E. A case for protein-level and site-level specificity in glycoproteomic studies of disease. Glycoconj J. 2016;33:377-85 pubmed publisher
    ..Each will be discussed with particular emphasis on how protein-specific and site-specific approaches can contribute to improved discrimination between glycoproteomes and glycoproteins associated with healthy and unhealthy states. ..
  35. Barra S, Bessler C, Landolt M, Aebi M. Patterns of Adverse Childhood Experiences in Juveniles Who Sexually Offended. Sex Abuse. 2017;:1079063217697135 pubmed publisher
    ..The present study used Latent Class Analysis (LCA) to derive subtypes of JSOs according to their patterns of 10 different ACEs...