CDK5RAP3

Summary

Gene Symbol: CDK5RAP3
Description: CDK5 regulatory subunit associated protein 3
Alias: C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, CDK5 regulatory subunit-associated protein 3, CDK5 regulatory subunit associated protein IC53-2, LXXLL/leucine-zipper-containing ARF-binding protein, LXXLL/leucine-zipper-containing ARFbinding protein, ischemic heart CDK5 activator-binding protein C53
Species: human

Top Publications

  1. doi Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
    Michael Steffens
    Institute for Medical Biometry, Informatic and Epidemiology, University of Bonn, Bonn, Germany
    Hum Mol Genet 21:5359-72. 2012
  2. pmc Expression of TIP-1 confers radioresistance of malignant glioma cells
    Miaojun Han
    Department of Radiation Oncology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 7:e45402. 2012
  3. pmc A novel LZAP-binding protein, NLBP, inhibits cell invasion
    Junhye Kwon
    Department of Biological Science, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    J Biol Chem 285:12232-40. 2010
  4. pmc A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling
    Jianchun Wu
    Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    J Biol Chem 285:15126-36. 2010
  5. ncbi Cloning of three novel neuronal Cdk5 activator binding proteins
    Y P Ching
    Department of Biochemistry, Hong Kong University of Science and Technology, Kowloon
    Gene 242:285-94. 2000
  6. pmc Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity
    Hiroki Shiwaku
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    EMBO J 29:2446-60. 2010
  7. pmc A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2
    Jialiang Wang
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem J 393:489-501. 2006
  8. doi Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis
    Grace Wing Yan Mak
    Departments of Anatomy and Pathology, Li Ka Shing Faculty of Medicine, and State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China
    Cancer Res 71:2949-58. 2011
  9. ncbi Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint
    Hai Jiang
    Children s Memorial Research Center, The Robert H Lurie Comprehensive Cancer Center, The Feinberg School of Medicine and IGP Graduate Program, Northwestern University, Chicago, Illinois 60614, USA
    J Biol Chem 280:20651-9. 2005
  10. ncbi Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Int J Mol Med 16:251-6. 2005

Research Grants

  1. Functional study of C53 protein as a novel regulator of checkpoint kinases
    Honglin Li; Fiscal Year: 2012
  2. Wendell G Yarbrough; Fiscal Year: 2016
  3. Creation and characterization of GH binding protein gene disrupted mice
    John Kopchick; Fiscal Year: 2007
  4. Tumor suppressor qualities and mechanisms of LZAP activity
    Wendell G Yarbrough; Fiscal Year: 2010

Scientific Experts

  • Indra Schroeder
  • R K Junnila
  • M L Green
  • John J Kopchick
  • D Stav
  • Lorraine Shack
  • N Chiba
  • Claudio C Carmo
  • Katleen Lemaire
  • Samuel L Krachman
  • Svetlana I Galkina
  • George A Kassavetis
  • Yasmin Bhurgri
  • L M Camargo
  • Y P Ching
  • Wendell G Yarbrough
  • Honglin Li
  • Jianchun Wu
  • Aneeshkumar G Arimbasseri
  • Hai Jiang
  • Keshab Rijal
  • Richard J Maraia
  • Grace Wing Yan Mak
  • Hanbing An
  • Carlos Fernández-Tornero
  • Eduarda Dráberová
  • Yinghua Zhang
  • Jingzhou Chen
  • Jialiang Wang
  • Junhye Kwon
  • Dan Liu
  • Jia Bin Wang
  • Camille Miller
  • Abdessalem Badri
  • Anja Ør Knudsen
  • Yogesh Singh
  • J Jacob Wamsley
  • Luciana Tartaglione
  • Kun Yang Lin
  • Thomas S Ream
  • Carolina Pereira Tavares
  • Alexa Patoine
  • Christina R Tyler
  • Natalia Issaeva
  • Christos D Katsetos
  • Vladimira Sladkova
  • Tetyana Sulimenko
  • Hernán Terenzi
  • Xinyuan Lu
  • Javier Vernal
  • Pavel Hozak
  • Vadym Sulimenko
  • Pavel Draber
  • G Chakalova
  • Dyego L B de Souza
  • Chang Hee Kim
  • Wen Der Wang
  • J Dabek
  • Geetha A Shetty
  • Tsunehisa Okuno
  • Camila Matiollo
  • Keerthi Gottipati
  • Mingsheng Zhang
  • Miaojun Han
  • Yonghong Lei
  • Barbora Hořejší
  • Michael Steffens
  • Hongtae Kim
  • Seung Hun Han
  • Irene Oi Lin Ng
  • Hyun Jung Cho
  • Jing Jing Zhao
  • James R Iben
  • Bridgette Oteng
  • Guohua Lei
  • Owen Jeffries
  • Hiroki Shiwaku
  • Shujian Cun
  • Cristina Rodríguez-Rieiro
  • Ming Lei Zhuo
  • Shouqing Luo
  • Seik Weng Ng
  • Bettina Bottcher
  • Ulrich Steuerwald
  • Christoph W Müller
  • Insa Kather
  • James A Henderson
  • Santiago Martinez-Calvillo
  • Kristina Lorenzen
  • Hui Yu

Detail Information

Publications92

  1. doi Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
    Michael Steffens
    Institute for Medical Biometry, Informatic and Epidemiology, University of Bonn, Bonn, Germany
    Hum Mol Genet 21:5359-72. 2012
    ..1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32. Further replication efforts are necessary to elucidate whether these positional candidate genes contribute to the heritability of the common GGE syndromes...
  2. pmc Expression of TIP-1 confers radioresistance of malignant glioma cells
    Miaojun Han
    Department of Radiation Oncology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 7:e45402. 2012
    ..In this study, TIP-1 was identified as one novel protein that confers resistance of glioma cells to IR...
  3. pmc A novel LZAP-binding protein, NLBP, inhibits cell invasion
    Junhye Kwon
    Department of Biological Science, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    J Biol Chem 285:12232-40. 2010
    LXXLL/leucine zipper-containing alternative reading frame (ARF)-binding protein (LZAP) was recently shown to function as a tumor suppressor through inhibition of the NF-kappaB signaling pathway...
  4. pmc A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling
    Jianchun Wu
    Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    J Biol Chem 285:15126-36. 2010
    C53/LZAP (also named as Cdk5rap3) is a putative tumor suppressor that plays important roles in multiple cell signaling pathways, including DNA damage response and NF-kappaB signaling...
  5. ncbi Cloning of three novel neuronal Cdk5 activator binding proteins
    Y P Ching
    Department of Biochemistry, Hong Kong University of Science and Technology, Kowloon
    Gene 242:285-94. 2000
    ..The full-length forms of these three novel proteins, designated C42, C48 and C53, have a molecular mass of 66, 24, and 57 kDa, respectively...
  6. pmc Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity
    Hiroki Shiwaku
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    EMBO J 29:2446-60. 2010
    ..Maxer is an endoplasmic reticulum (ER) membrane protein interacting with CDK5RAP3. Maxer anchors CDK5RAP3 to the ER and inhibits its function of Cyclin D1 transcription repression in the nucleus...
  7. pmc A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2
    Jialiang Wang
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem J 393:489-501. 2006
    ..Using a yeast two-hybrid screen, we have identified a novel protein, LZAP (LXXLL/leucine-zipper-containing ARF-binding protein), that interacts with endogenous ARF in mammalian cells...
  8. doi Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis
    Grace Wing Yan Mak
    Departments of Anatomy and Pathology, Li Ka Shing Faculty of Medicine, and State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China
    Cancer Res 71:2949-58. 2011
    The CDK5 kinase regulatory subunit-associated protein 3 (CDK5RAP3 or C53/LZAP) regulates apoptosis induced by genotoxic stress...
  9. ncbi Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint
    Hai Jiang
    Children s Memorial Research Center, The Robert H Lurie Comprehensive Cancer Center, The Feinberg School of Medicine and IGP Graduate Program, Northwestern University, Chicago, Illinois 60614, USA
    J Biol Chem 280:20651-9. 2005
    ..Here we report the involvement of Cdk5 activator p35-binding protein C53 in regulation of apoptosis induced by genotoxic stress through modulating Cdk1-cyclin B1 function...
  10. ncbi Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Int J Mol Med 16:251-6. 2005
    ..The carboxy terminal region of CBP (including the C/H3 region) was utilized as a bait. C53, a 57 kDa protein known to bind to the p25 activator of cyclin-dependent kinase 5, was identified as a novel ..
  11. pmc Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation
    Hai Jiang
    Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Cell Res 19:458-68. 2009
    ..We originally reported that a novel protein C53 (also known as Cdk5rap3 and LZAP) potentiates DNA damage-induced cell death by modulating the G2/M checkpoint. More recently, Wang et al...
  12. ncbi LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB
    Jialiang Wang
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Cell 12:239-51. 2007
    b>LZAP has been reported to inhibit cellular proliferation and clonogenic growth. Here, we report that decreased LZAP expression promoted cellular transformation, xenograft tumor growth, and xenograft tumor vascularity...
  13. doi RCAD/BiP Pathway is Necessary for the Proper Synthesis of Digestive Enzymes and the Secretory Function of the Exocrine Pancreas
    Camille Miller
    Augusta University
    Am J Physiol Gastrointest Liver Physiol . 2017
    ..Among the components of the Ufm1 system, Regulator of C53 and DDRGK1 (RCAD) has recently been identified as an Ufm1-specific E3 ligase that promotes ufmylation of DDRGK1, a ..
  14. pmc LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro
    J Jacob Wamsley
    a Department of Surgery, Division of Otolaryngology, Yale University, New Haven, CT, USA
    Cell Cycle . 2016
    ..Wip1 also dephosphorylates and inactivates RelA. Notably, LZAP, a putative tumor suppressor, has been linked to dephosphorylation of several of these substrates, including RelA, ..
  15. doi CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling
    Jia Bin Wang
    Department of Gastric Surgery, Fujian Medical University Union Hospital, No 29 Xinquan Road, Fuzhou 350001, Fujian Province, People s Republic of China
    Cancer Lett 385:188-197. 2017
    b>CDK5RAP3 was isolated as a binding protein of the Cdk5 activator p35. Although CDK5RAP3 has been implicated in cancer progression, its expression and function have not been investigated in gastric cancer...
  16. pmc RbZnFe(PO4)2: synthesis and crystal structure
    Abdessalem Badri
    Unite de Recherche, Matériaux Inorganiques, Faculte des Sciences, Universite de Monastir, 5019 Monastir, Tunisia
    Acta Crystallogr E Crystallogr Commun 72:1074-6. 2016
    ..This compound is isostructural to the previously reported KCoAl(PO4)2 [Chen et al. (1997 ▸). Acta Cryst. C53,1754-1756]...
  17. doi Selective disruption of disulphide bonds lowered activation energy and improved catalytic efficiency in TALipB from Trichosporon asahii MSR54: MD simulations revealed flexible lid and extended substrate binding area in the mutant
    Yogesh Singh
    Department of Microbiology, University of Delhi South Campus, New Delhi 110021, India
    Biochem Biophys Res Commun 472:223-30. 2016
    ..DIANNA server predicted three disulphide bridges C53-C195 (S1), C89-C228 (S2) and C164-C254 (S3) in the enzyme...
  18. ncbi Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
    L M Camargo
    Merck Research Labs, Merck and Co, Boston, MA 02115, USA
    Mol Psychiatry 12:74-86. 2007
    ....
  19. doi Trends in gynecologic cancer among elderly women in Denmark, 1980-2012
    Anja Ør Knudsen
    a Department of Oncology, Odense University Hospital
    Acta Oncol 55:65-73. 2016
    ..The aim of this analysis was to describe trends in incidence, mortality, prevalence, and survival in Danish women with gynecologic cancer from 1980-2012 comparing women aged 70 years or more with younger women...
  20. doi Chemical, molecular, and eco-toxicological investigation of Ostreopsis sp. from Cyprus Island: structural insights into four new ovatoxins by LC-HRMS/MS
    Luciana Tartaglione
    Department of Pharmacy, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Anal Bioanal Chem 408:915-32. 2016
    ..the presence of a hydroxyl group at C44 (in OVTX-j1 and OVTX-k) and the lack of a hydroxyl group in the region C53-C78 (in OVTX-i and OVTX-j1). The toxin content of the analyzed Ostreopsis sp. strains was in the range 0.06-2...
  21. pmc Tumor Suppressor Lzap Suppresses Wnt/β-Catenin Signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of Glycogen Synthase Kinase 3
    Kun Yang Lin
    From the Institute of Cellular and Organismic Biology, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan, Department of Bioagricultural Science, National Chiayi University, Chiayi 60004, Taiwan, and
    J Biol Chem 290:29808-19. 2015
    ..However, regulations of this signaling pathway are not completely understood. Here, we report that Lzap, a tumor suppressor, controls nuclear translocation of β-catenin...
  22. doi Topological mapping of BRIL reveals a type II orientation and effects of osteogenesis imperfecta mutations on its cellular destination
    Alexa Patoine
    Shriners Hospital for Children, Montreal, Quebec, Canada Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 29:2004-16. 2014
    ..BRIL was found to be palmitoylated and two conserved cysteine residues (C52 and C53) were critical for targeting to the plasma membrane...
  23. pmc Prenatal alcohol exposure alters expression of neurogenesis-related genes in an ex vivo cell culture model
    Christina R Tyler
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Alcohol 48:483-92. 2014
    ..Under differentiating conditions, 7.3% of genes had decreased mRNA expression; these include Cdk5rap3, Gdnf, Hey2, Heyl, Pard6b, and Ptn, which are associated with survival and differentiation as indicated by ..
  24. ncbi In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: species differences and stereoselectivity
    E A Cannady
    Department of Drug Disposition, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN, USA
    Xenobiotica 36:659-70. 2006
    ..enzyme kinetics of the glutathione (GSH) conjugation of cryptophycin 52 (C52, R-stereoisomer) and cryptophycin 53 (C53, S-stereoisomer) by cytosolic glutathione S-transferases (cGSTs) from human, rat, mouse, dog and monkey liver were ..
  25. pmc Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit
    Thomas S Ream
    Division of Biology and Biomedical Sciences, Washington University, St Louis, MO 63130, USA
    Nucleic Acids Res 43:4163-78. 2015
    ..Two genes encode homologs of the yeast C53 subunit and either protein can assemble into Pol III...
  26. doi Overexpression and Nucleolar Localization of γ-Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma
    Eduarda Dráberová
    From the Departments of Biology of Cytoskeleton ED, VS, TS, VS, PD and Biology of the Nucleus MS, PH, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic Department of Pediatrics LD, ET, AL, CDK, Drexel University College of Medicine, Section of Pediatric Neurology and Neurooncology Program AL, CDK, St Christopher s Hospital For Children, and Department of Pathology and Laboratory Medicine NFM, CDK Drexel University College of Medicine, Philadelphia, Pennsylvania Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania VC, AG Department of Clinical Cytology, Sismanoglion General Hospital, Athens, Greece NFM Department of Pathology, KAT General Hospital, Athens, Greece EM Department of Pathology, Faculty Hospital Brno, Brno, Czech Republic LK and Gades Institute, Department of Pathology, University of Bergen, Haukeland Hospital, Federal Republic of Germany
    J Neuropathol Exp Neurol 74:723-42. 2015
    ..of GCP2 antagonized the inhibitory effect of the CDK5 regulatory subunit-associated tumor suppressor protein 3 (C53) on DNA damage G2/M checkpoint activity...
  27. ncbi Significance of the disulphide bonds of human growth hormone
    Riia K Junnila
    Edison Biotechnology Institute, Ohio University, Athens, Ohio, United States
    Endokrynol Pol 64:300-5. 2013
    Growth hormone (GH) structure is stabilised by two disulphide bonds, C53-C165 and C182-C189 in human GH. Researchers have investigatedthe role of these structural features since the late 1960s...
  28. doi S-nitrosylation influences the structure and DNA binding activity of AtMYB30 transcription factor from Arabidopsis thaliana
    Carolina Pereira Tavares
    Centro de Biologia Molecular Estrutural INBEB, Departamento de Bioquimica, CCB, Universidade Federal de Santa Catarina, Florianopolis, Brazil
    Biochim Biophys Acta 1844:810-7. 2014
    ..active minimal DNA-binding domain (DBD) of AtMYB30 (residues 11-116) containing two cysteine residues (C49 and C53) was overexpressed and purified. Site-directed mutagenesis was used to obtain AtMYB30 DBD mutants C49A and C53A...
  29. pmc Neural stem cell- and neurogenesis-related gene expression profiles in the young and aged dentate gyrus
    Geetha A Shetty
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, 5701 Airport Road, Module C, Temple, 76502, TX, USA
    Age (Dordr) 35:2165-76. 2013
    ..important for NSC proliferation and neurogenesis (Stat3 and Shh), DNA damage response and NF-kappaB signaling (Cdk5rap3), neuromodulation (Adora1), and decreased expression of a gene important for neuronal differentiation (HeyL)...
  30. doi Mortality trends and prediction of HPV-related cancers in Brazil
    Dyego L B de Souza
    Department of Public Health, Federal University of Rio Grande do Norte, Natal, RN, Brazil
    Eur J Cancer Prev 22:380-7. 2013
    ..All deaths registered as being a result of cervical cancer (ICD-10 code: C53), as well as those caused by vulvar and vaginal (C51 and C52), anal (C21), penile (C60), and oropharyngeal (C02, ..
  31. pmc Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking
    Yinghua Zhang
    Department of Biochemistry and Molecular Biology, Cancer Center, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 7:e48587. 2012
    ..present the evidence for involvement of RCAD/Ufl1, a putative Ufm1-specific E3 ligase, and its binding partner C53/LZAP protein in ufmylation of endogenous Ufm1 targets...
  32. pmc Transcription termination by the eukaryotic RNA polymerase III
    Aneeshkumar G Arimbasseri
    Intramural Research Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2426, USA
    Biochim Biophys Acta 1829:318-30. 2013
    ..termination is autonomous involving the core subunits C2 and probably C1, it also involves subunits C11, C37 and C53, which act on the pol III catalytic center and exhibit homology to the pol II elongation factor TFIIS and TFIIFα/β..
  33. doi S-nitrosylation of Mycobacterium tuberculosis tyrosine phosphatase A (PtpA) induces its structural instability
    Camila Matiollo
    Centro de Biologia Molecular Estrutural INBEB, Departamento de Bioquimica, CCB, Universidade Federal de Santa Catarina, Florianopolis, Brazil
    Biochim Biophys Acta 1834:191-6. 2013
    ..post-translational modification decreases the activity of the enzyme upon modification of a single Cys residue, C53. The aim of the present work was the investigation of the effect of S-nitrosylation in PtpA kinetic parameters, ..
  34. pmc RNA polymerase III mutants in TFIIFα-like C37 that cause terminator readthrough with no decrease in transcription output
    Keshab Rijal
    Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Nucleic Acids Res 41:139-55. 2013
    How eukaryotic RNA polymerases switch from elongation to termination is unknown. Pol III subunits Rpc53 and Rpc37 (C53/37) form a heterodimer homologous to TFIIFβ/α...
  35. pmc Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction
    M L Green
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, 501 S Preston St, Louisville, KY 40202, USA Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA Electronic address
    Cell Signal 25:2383-90. 2013
    ..genetic background were transfected with p53-EGFP fusion protein led by a sense (m53-EGFP) or antisense (c53-EGFP) mitochondrial import signal...
  36. pmc CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells
    Grace Wing Yan Mak
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 7:e42210. 2012
    b>CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis...
  37. doi The role of human growth hormone's C-terminal disulfide bridge
    R K Junnila
    Department of Clinical Endocrinology, Campus Charite Mitte, Charite Universitaetsmedizin, Berlin, Germany
    Growth Horm IGF Res 23:62-7. 2013
    ..members of the same polypeptide hormone family, have a four-helix bundle structure linked by two disulfide bridges, C53-C165 and C182-C189 in hGH...
  38. ncbi A unique pause pattern during telomere addition by the error-prone telomerase from the ciliate Paramecium tetraurelia
    Amanda J Ye
    Department of Pharmacology, Medical School, University of Minnesota, 6 120 Jackson Hall, 321 Church Street S E, Minneapolis, MN 55455, USA
    Gene 294:205-13. 2002
    ..Instead, the pause by P. tetraurelia telomerase is at templating nucleotide C53, immediately prior to incorporation of dGTP (or TTP) at C52...
  39. ncbi Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design
    Gabriela Aguirre
    Departamento de Quimica Organica, Facultad de Quimica Facultad de Ciencias, Igua 4225, 11400 Montevideo, Uruguay
    Eur J Med Chem 39:421-31. 2004
    ..The physicochemical environment around E19, W22, C53 and Y111 residues within the trypanothione binding site of trypanothione reductase resulted a valuable target for ..
  40. ncbi Cancer burden of breast and gynecological cancers in Bulgaria: epidemiology and clinical aspects
    G Chakalova
    Department of Gynecologic Oncology, National Oncology Hospital, Sofia, Bulgaria
    J BUON 18:1038-44. 2013
    ..The purpose of this study was to estimate the burden of breast and gynecological cancers in Bulgaria, analyzing trends of incidence, mortality and survival for the past two decades...
  41. pmc A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation
    Emilie Landrieux
    CEA Saclay, Laboratoire de Transcription des Gènes, Service de Biochimie et de Génétique Moléculaire, Gif sur Yvette, France
    EMBO J 25:118-28. 2006
    ..of the in vitro transcriptional properties of a Pol III variant (Pol IIIdelta), lacking the C11, C37, and C53 subunits, revealed crucial information about the mechanisms of Pol III termination and reinitiation...
  42. ncbi Host cell responses of Salmonella typhimurium infected human dendritic cells
    Stephen Gitahi Kiama
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Immunol Cell Biol 84:475-81. 2006
    ..and SipB and the wild-type strains of the American Type Culture Collection (Manassas, VA, USA), ATCC 14028 and ATCC C53, by electron microscopy at 30 min, 3 h and 24 h after exposure...
  43. pmc The structure of classical swine fever virus N(pro): a novel cysteine Autoprotease and zinc-binding protein involved in subversion of type I interferon induction
    Keerthi Gottipati
    Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
    PLoS Pathog 9:e1003704. 2013
    ..Due to its unique sequence and catalytic site, it forms its own cysteine protease family C53. After self-cleavage, N(pro) is no longer active as a protease...
  44. pmc Overexpression of a novel regulator of p120 catenin, NLBP, promotes lung adenocarcinoma proliferation
    Chang Hee Kim
    Department of Biological Sciences Sungkyunkwan University Suwon, Republic of Korea
    Cell Cycle 12:2443-53. 2013
    NLBP (novel LZAP-binding protein) was recently shown to function as a tumor suppressor capable of inhibiting the NFκB signaling pathway...
  45. doi Transcription activity of MMP-2 and MMP-9 metalloproteinase genes and their tissue inhibitor (TIMP-2) in acute coronary syndrome patients
    J Dabek
    Department of Epidemiology, Medical University of Silesia, Katowice, Poland
    J Postgrad Med 59:115-20. 2013
    ..One of the ACS causative factors is the deranged ratio equilibrium of the matrix metalloproteinase/tissue inhibitor of metalloproteinases (MMPs/TIMPs)...
  46. pmc A new polymorph of 1,3-bis-(penta-fluoro-phen-yl)urea
    Tsunehisa Okuno
    Department of Material Science and Chemistry, Wakayama University, Sakaedani, Wakayama, 640 8510, Japan
    Acta Crystallogr Sect E Struct Rep Online 69:o608. 2013
    ..1997 ▶). Acta Cryst. C53, 455-457]. The current P212121 polymorph was obtained from a tetra-hydro-furan solution...
  47. doi Creation of a reactive oxygen species-insensitive Kcv channel
    Indra Schroeder
    Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milano, Italy
    Biochemistry 52:3130-7. 2013
    ..Possible targets for the ROS effect are two cysteines (C53 and C79) and four methionines (M1, M15, M23, and M26)...
  48. pmc Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope
    Jianchun Wu
    Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cell Res 23:691-704. 2013
    ..We found that the NE rupture was caused by caspase-mediated cleavage of C53/LZAP, a protein that has been implicated in various signaling pathways, including NF-κB signaling and DNA damage ..
  49. pmc Distinguishing core and holoenzyme mechanisms of transcription termination by RNA polymerase III
    Aneeshkumar G Arimbasseri
    Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 33:1571-81. 2013
    ..A core mechanism can operate in the absence of C53/37 and C11 subunits but requires synthesis of 8 or more 3' U nucleotides, apparently reflecting inherent ..
  50. pmc Conformational flexibility of RNA polymerase III during transcriptional elongation
    Carlos Fernández-Tornero
    European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany
    EMBO J 29:3762-72. 2010
    ..sub-classification reveals prominent EM densities for the two Pol III-specific subcomplexes, C31/C82/C34 and C37/C53, that can be interpreted using homology models...
  51. pmc Identification of LZAP as a new candidate tumor suppressor in hepatocellular carcinoma
    Jing Jing Zhao
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    PLoS ONE 6:e26608. 2011
    b>LZAP was isolated as a binding protein of the Cdk5 activator p35. LZAP has been highly conserved during evolution and has been shown to function as a tumor suppressor in various cancers...
  52. doi Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma
    Yonghong Lei
    Wound Healing and Cell Biology Laboratory, The First Affiliated Hospital, and Camital Medical University, Beijing 100853, PR China
    Oncol Rep 27:151-9. 2012
    ..Sequencing of the positive clones identified the full-length cDNA of the C53 gene...
  53. pmc Low-temperature redetermination of tribenzyl-chloridotin(IV)
    Seik Weng Ng
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Acta Crystallogr E Struct Rep Online 65:m238. 2009
    Compared to the previous studies [Ng (1997 ▶). Acta Cryst. C53, 56-58; Yin et al. (2005 ▶). Huaxue Shiji, 27, 295-296], the redetermined structure of the title compound, [Sn(C(7)H(7))(3)Cl], exhibits a doubled c unit-cell parameter...
  54. pmc Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly
    Dan Liu
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Dev Dyn 240:1613-25. 2011
    ..b>Lzap is a putative tumor suppressor whose expression is lost in 30% of head and neck squamous cell carcinomas...
  55. pmc Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits
    Ping Hu
    Graduate Program of Molecular and Cellular Biology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Mol Cell Biol 22:8044-55. 2002
    ..RPC5 associated with RPC53, the human orthologue of S. cerevisiae C53, paralleling the association of the S...
  56. ncbi Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma
    D Stav
    Pulmonary Institute, Assaf Harofeh Medical Center, Zerifin, Israel
    Int J Biol Markers 22:108-13. 2007
    ..We analyzed CDK5RAP3 and CCNB2, which are involved in cell cycle progression, and RAGE...
  57. ncbi Insights into transcription initiation and termination from the electron microscopy structure of yeast RNA polymerase III
    Carlos Fernández-Tornero
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, 38042 Grenoble, France
    Mol Cell 25:813-23. 2007
    ..the latter primarily to five RNAPIII-specific subunits, present as two distinct subcomplexes (C82/C34/C31 and C53/C37)...
  58. pmc Characterization of the RNA polymerase II and III complexes in Leishmania major
    Santiago Martinez-Calvillo
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109 5219, USA
    Int J Parasitol 37:491-502. 2007
    ..The latter experiments also identified the RNAP III subunits RPC1 (C160), RPC2 (C128), RPC3 (C82), RPC4 (C53), RPC5 (C37), RPC6 (C34), RPC9 (C17), RPAC1 (AC40) and RPAC2 (AC19)...
  59. ncbi Structure-function analysis of the soluble glycoprotein, sGP, of Ebola virus
    Darryl Falzarano
    Department of Medical Microbiology, University of Manitoba Winnipeg, Manitoba R3E 0W3, Canada
    Chembiochem 7:1605-11. 2006
    ..Our data prove that sGP is a parallel homodimer that contains C53-C53' and C306-C306' disulfide bonds, and although there are six predicted N-linked carbohydrate sites, only five ..
  60. ncbi CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation
    Eugene Kim
    Division of Surgical Oncology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Int J Oncol 28:191-4. 2006
    ..This is the first report of cdk5/p35 expression and kinase activity in colon cancer cells, which is associated with ciglitazone-induced antiproliferation in HT-29 cells...
  61. pmc Induction of HSF1 expression is associated with sporadic colorectal cancer
    Hui Cen
    Cancer Institute, the Second Affiliated Hospital of Medical School, Zhejiang University, Hanzhou 310009, Zhejiang Province, China
    World J Gastroenterol 10:3122-6. 2004
    ..To explore the activation of signal transduction pathways related with the carcinogenesis of sporadic colon cancers...
  62. ncbi Disulfide bond assignment of the Ebola virus secreted glycoprotein SGP
    Laura G Barrientos
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Biochem Biophys Res Commun 323:696-702. 2004
    ..in a parallel manner by two intersubunit disulfide bonds formed between paired N-terminal and C-terminal cysteines (C53-C53' and C306-C306')...
  63. pmc The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
    Rosa M Canet-Aviles
    Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda, MD 20892 1589, USA
    Proc Natl Acad Sci U S A 101:9103-8. 2004
    ..We observed a cysteine-sulfinic acid at C106 in crystalline DJ-1 but no modification of C53 or C46. Oxidation of DJ-1 was promoted by the crystallization procedure...
  64. ncbi Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein
    Yi Hu Xie
    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032, China
    Cell Res 13:83-91. 2003
    We have identified IC53-2, a human homologue of the rat C53 gene from a human placenta cDNA library (GeneBank Accession No.AF217982). IC53-2 can bind to the CDK5 activator p35 by in vitro association assay...
  65. ncbi Structural biology of RNA polymerase III: mass spectrometry elucidates subcomplex architecture
    Kristina Lorenzen
    Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research and Utrecht Institute for Chemistry, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Structure 15:1237-45. 2007
    ..contains a single copy of each subunit and revealed a 15 subunit form lacking the Pol III-specific subcomplex C53/37...
  66. ncbi A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart
    Jingzhou Chen
    Sino German Laboratory for Molecular Medicine and Center for Molecular Cardiology, Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 167 Beilishilu, Beijing 100037, China
    Biochem Biophys Res Commun 294:161-6. 2002
    ..A novel gene with 84% homolog to C53, named IC53, was cloned from our 5300 EST database of human aorta cDNA library (GenBank Accession No. AF110322)...
  67. pmc Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment-Helicobacter pylori positive (CADET-Hp) randomised controlled trial
    Naoki Chiba
    Division of Gastroenterology, McMaster University, Hamilton, ON, Canada L8N 3Z5
    BMJ 324:1012-6. 2002
    ..To determine whether a "test for Helicobacter pylori and treat" strategy improves symptoms in patients with uninvestigated dyspepsia in primary care...
  68. ncbi Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
    Yick Pang Ching
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 277:15237-40. 2002
    ..The Pho85.Pho80 kinase complex has been shown to be the yeast functional homologue of the mammalian Cdk5/p35(nck5a) kinase...
  69. ncbi Identification of a common protein association region in the neuronal Cdk5 activator
    X Wang
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Peoples Republic of China
    J Biol Chem 275:31763-9. 2000
    ..have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000) Gene 242, 285-294)...
  70. ncbi Mutagenesis of the proposed iron-sulfur cluster binding ligands in Escherichia coli biotin synthase
    K S Hewitson
    Dyson Perrins Laboratory, University of Oxford, UK
    FEBS Lett 466:372-6. 2000
    ..Three mutant enzymes of BioB have been made, each with one cysteine residue (C53, 57, 60) mutated to alanine...
  71. pmc A protein-protein interaction map of yeast RNA polymerase III
    A Flores
    Service de Biochimie et Génétique Moléculaire, Bat 142, Commissariat à l Energie Atomique Saclay, F 91191 Gif sur Yvette Cedex, France
    Proc Natl Acad Sci U S A 96:7815-20. 1999
    ..These regions overlapped with highly conserved domains. C53, a pol III-specific subunit, interacted with a 37-kDa polypeptide that copurifies with the enzyme and therefore ..
  72. ncbi Interaction between a complex of RNA polymerase III subunits and the 70-kDa component of transcription factor IIIB
    M Werner
    Departement de Biologie Cellulaire et Moleculaire, Batiment 142, Centre d Etudes de Saclay, Gif sur Yvette, France
    J Biol Chem 268:20721-4. 1993
    ..to study protein-protein interactions between four essential and unique subunits of yeast RNA polymerase III (C82, C53, C34 and C31), the 70-kDa component of the initiation transcription factor IIIB (TFIIIB70) and the TATA-binding ..
  73. pmc RPC53 encodes a subunit of Saccharomyces cerevisiae RNA polymerase C (III) whose inactivation leads to a predominantly G1 arrest
    C Mann
    Service de Biochimie et Génétique Moléculaire, Centre d Etudes de Saclay, Gif sur Yvette, France
    Mol Cell Biol 12:4314-26. 1992
    RPC53 is shown to be an essential gene encoding the C53 subunit specifically associated with yeast RNA polymerase C (III)...
  74. pmc A zinc-binding site by negative selection induces metallodrug susceptibility in an essential chaperonin
    Shujian Cun
    Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Pokfulam Road, Hong Kong, China
    Proc Natl Acad Sci U S A 107:4943-8. 2010
    ..Additionally, three more (H45, C51, and C53) are uniquely present in its apical domain...
  75. pmc Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis
    Katleen Lemaire
    Gene Expression Unit, Department Molecular Cell Biology, KatholiekeUniversiteit Leuven, Leuven, Belgium
    PLoS ONE 6:e18517. 2011
    ..that the recently identified C20orf116, which we name UFM1-binding protein 1 containing a PCI domain (UFBP1), and CDK5RAP3 interact with UFM1...
  76. doi Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53
    Barbora Hořejší
    Department of Biology of Cytoskeleton, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Czech Republic
    J Cell Physiol 227:367-82. 2012
    ..extracts combined with mass spectrometry revealed an association of γ-tubulin with tumor suppressor protein C53 located at multiple subcellular compartments including nucleoli...
  77. pmc Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III
    James R Iben
    Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Commissioned Corps, US Public Health Service, Bethesda, MD, USA 20892
    Nucleic Acids Res 39:6100-13. 2011
    ..Y30, F32 and I34 of C11 in available cryoEM pol III structures predicts a hydrophobic patch that may interface with C53/37. Another termination mutant, Rpc2-T455I, appears to reside internally, near the RNA-DNA hybrid...
  78. pmc A functional variant of IC53 correlates with the late onset of colorectal cancer
    Jingzhou Chen
    Sino German Laboratory for Molecular Medicine, Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Mol Med 17:607-18. 2011
    The IC53 gene was reported to be upregulated in the colon adenocarcinoma cell line SW480. Here, we show that the expression level of IC53 is positively correlated with the grade and depth of invasion in adenocarcinoma of the colon...
  79. pmc LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)
    Hanbing An
    Department of Otolaryngology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16427. 2011
    LZAP (Cdk5rap3, C53) is a putative tumor suppressor that inhibits RelA, Chk1 and Chk2 and activates p53...
  80. doi Membrane tubules attach Salmonella Typhimurium to eukaryotic cells and bacteria
    Svetlana I Galkina
    A N Belozersky Institute of the Moscow State University, Moscow, Russia
    FEMS Immunol Med Microbiol 61:114-24. 2011
    ..The tubular appendage diameter of bacteria of virulent flagellated C53 strain varied between 60 and 70 nm, thus considerably exceeding in size of flagella or pili...
  81. ncbi Specific valylation of turnip yellow mosaic virus RNA by wheat germ valyl-tRNA synthetase determined by three anticodon loop nucleotides
    T W Dreher
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    Biochemistry 31:9183-9. 1992
    ..of the anticodon (A56 in TYMV RNA), the 3' anticodon nucleotide (C55), and the 3'-most anticodon loop nucleotide (C53)...
  82. doi Evaluating societal preferences for human papillomavirus vaccine and cervical smear test screening programme
    Bridgette Oteng
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver V5Z163, British Columbia, Canada
    Sex Transm Infect 87:52-7. 2011
    ..Public preferences for HPV vaccines and smear test screening were determined using a discrete choice experiment...
  83. pmc Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels
    Owen Jeffries
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Biol Chem 285:33307-14. 2010
    ..of cell surface expression of BK channels, as steady state surface expression levels are reduced by ∼55% in the C53:54:56A mutant...
  84. doi Physiologic correlates of sleep quality in severe emphysema
    Samuel L Krachman
    Dept of Pulmonary, Critical Care, and Sleep, Temple University School of Medicine, Philadelphia, Pennsylvania, 19140, USA
    COPD 8:182-8. 2011
    ..Sleep quality is poor in severe emphysema. We hypothesized that in addition to nocturnal oxygen desaturation, the severity of airflow obstruction and degree of thoracic hyperinflation are responsible...
  85. doi Indication of radiotherapy for women with cervical cancer in Rio De Janeiro, Brazil
    Claudio C Carmo
    Division of Clinical Oncology, Brazilian National Cancer Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Int J Gynecol Cancer 20:158-63. 2010
    ..All cases of primary invasive tumors of the cervix (CID C53) registered at the institute and diagnosed between 1999 and 2004 were selected...
  86. pmc The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening
    George A Kassavetis
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 285:2695-706. 2010
    The C53 and C37 subunits of RNA polymerase III (pol III) form a subassembly that is required for efficient termination; pol III lacking this subcomplex displays increased processivity of RNA chain elongation...
  87. doi Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice
    Ming Lei Zhuo
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, PR China
    Cardiovasc Res 84:292-9. 2009
    ..Endothelial cells (ECs) exert important functions in the regulation of blood pressure. A novel gene, IC53, as an isoform of the cyclin-dependent kinase (CDK)-binding protein gene C53, is mainly expressed in vascular ECs ..
  88. doi [Temporal trends of cervical cancer mortality rates among regions in Spain: 1975-2004]
    Cristina Rodríguez-Rieiro
    Servicio de Medicina Preventiva y Gestión de Calidad, Hospital General Universitario Gregorio Maranon, Madrid, Espana
    Med Clin (Barc) 133:41-6. 2009
    ..To estimate the temporal trend of the cervical cancer mortality rates among Autonomous Communities (AACC) in Spain...
  89. pmc Variation in incidence of breast, lung and cervical cancer and malignant melanoma of skin by socioeconomic group in England
    Lorraine Shack
    North West Cancer Intelligence Service, Christie Hospital NHS Trust, Kinnaird Road, Withington, Manchester, M20 4QL, UK
    BMC Cancer 8:271. 2008
    ..Socioeconomic variations in cancer incidence by region and age are less clearly understood but they are crucial for targeting prevention measures and health care commissioning...
  90. doi Changing the determinants of protein stability from covalent to non-covalent interactions by in vitro evolution: a structural and energetic analysis
    Insa Kather
    Laboratorium fur Biochemie, Universitat Bayreuth, 95440 Bayreuth, Germany
    J Mol Biol 381:1040-54. 2008
    ..the disulfide-containing wild-type protein, (ii) optimized the local packing with the residues that replace the C46-C53 disulfide and (iii) improved the domain interactions...
  91. ncbi Patho-epidemiology of Cancer Cervix in Karachi South
    Yasmin Bhurgri
    Karachi Cancer Registry, Aga Khan University
    Asian Pac J Cancer Prev 8:357-62. 2007
    ..The present study was conducted with the objective of examining descriptive epidemiological and pathological characteristics of cancer cervix in Karachi South, an all urban district population of Karachi, Pakistan...
  92. ncbi Highly functionalized pyranopyrans from furans: a synthesis of the C27-C38 and C44-C53 subunits of norhalichondrin B
    James A Henderson
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309 0215, USA
    Org Lett 9:5299-302. 2007
    ..A synthesis of highly functionalized pyranopyrans based on an Achmatowicz oxidation followed by a remarkably diastereoselective Kishi reduction is described in the context of studies directed toward norhalichondrin B...

Research Grants4

  1. Functional study of C53 protein as a novel regulator of checkpoint kinases
    Honglin Li; Fiscal Year: 2012
    Our long-term goal is to elucidate the roles of a novel protein C53 in regulation of cell cycle progression and DNA damage response, and to explore potential utilization of this novel protein as a novel therapeutic target...
  2. Wendell G Yarbrough; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): We discovered LZAP as a novel binding partner of the alternate reading frame protein ARF (p14ARF in humans, p19ARF in mice)...
  3. Creation and characterization of GH binding protein gene disrupted mice
    John Kopchick; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Tumor suppressor qualities and mechanisms of LZAP activity
    Wendell G Yarbrough; Fiscal Year: 2010
    ..Recently, we have found a novel protein, LZAP, (leucine zipper containing ARF-binding protein) that binds ARF in the nucleus and regulates ARF biochemical ..