CDKN2B

Summary

Gene Symbol: CDKN2B
Description: cyclin dependent kinase inhibitor 2B
Alias: CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase 4 inhibitor B, CDK inhibitory protein, CDK4B inhibitor, MTS-2, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), cyclin-dependent kinases 4 and 6 binding protein, multiple tumor suppressor 2, p14-INK4b, p14_CDK inhibitor, p14_INK4B, p15 CDK inhibitor, p15-INK4b, p15_INK4B
Species: human

Top Publications

  1. doi Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    J Mol Med (Berl) 86:341-8. 2008
  2. doi Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan
    Yukio Horikawa
    Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
    J Clin Endocrinol Metab 93:3136-41. 2008
  3. pmc 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data
    Jie Huang
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Eur J Hum Genet 20:801-5. 2012
  4. ncbi p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
    Federica Perrone
    Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori di Milano, Via G Venezian 1, 20133 Milan, Italy
    Clin Cancer Res 9:4132-8. 2003
  5. pmc Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1802, USA
    J Clin Endocrinol Metab 94:1826-34. 2009
  6. ncbi Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas
    R G Weber
    Department of Human Genetics, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Oncogene 26:1088-97. 2007
  7. doi Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
    M J Groenewoud
    Department of Molecular Cell Biology, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 51:1659-63. 2008
  8. ncbi Repression of p15INK4b expression by Myc through association with Miz-1
    P Staller
    Institute of Molecular Biology and Tumour Research, Emil Mannkopff Strabetae 2, 35033 Marburg, Germany
    Nat Cell Biol 3:392-9. 2001
  9. ncbi Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma
    Nicholas Hearle
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
    Invest Ophthalmol Vis Sci 44:458-62. 2003
  10. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007

Research Grants

  1. Definition of chromosomal abnormalities by next generation sequencing
    Nara Sobreira; Fiscal Year: 2012
  2. Maintenance therapy with decitabine for acute myeloid leukemia in first remission
    William G Blum; Fiscal Year: 2010
  3. Randomized study of combined epigenetic therapy
    Jean Pierre J Issa; Fiscal Year: 2011
  4. MAPPING SURFACE CONTACTS IN BIOMACROMOLECULE COMPLEXES
    Alan Marshall; Fiscal Year: 2000
  5. P16 GENE FAMILY IN HEALTH AND DISEASE
    Gregory Hannon; Fiscal Year: 1999
  6. 5-Azacytidine and MS-275 in Myeloid Malignancies
    Steven Gore; Fiscal Year: 2005
  7. Joan Massague; Fiscal Year: 2014
  8. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
  9. TUBA FEHR; Fiscal Year: 2015
  10. NICHOLAS JAMES LEEPER; Fiscal Year: 2014

Detail Information

Publications225 found, 100 shown here

  1. doi Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    J Mol Med (Berl) 86:341-8. 2008
    ..E.S.I.R. prospective cohort. However, in contrast to TCF7L2, the contribution of novel loci to T2D incidence seems only modest in the general middle-aged French population and should be replicated in larger cohorts...
  2. doi Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan
    Yukio Horikawa
    Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
    J Clin Endocrinol Metab 93:3136-41. 2008
    ..and populations of European origin, several groups have recently identified novel type 2 diabetes susceptibility genes, including FTO, SLC30A8, HHEX, CDKAL1, CDKN2B, and IGF2BP2, none of which were in the list of functional candidates.
  3. pmc 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data
    Jie Huang
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Eur J Hum Genet 20:801-5. 2012
    ..One is within the IL2RA gene for association with type 1 diabetes and the other in proximity with the CDKN2B gene for association with type 2 diabetes. We also identified two refined associations...
  4. ncbi p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
    Federica Perrone
    Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori di Milano, Via G Venezian 1, 20133 Milan, Italy
    Clin Cancer Res 9:4132-8. 2003
    ..of this chromosomal region, in this study we performed a comprehensive, mostly PCR-based molecular analysis of the three tumor suppressor genes p15(INK4b), p14(ARF) and p16(INK4a) located at the 9p21 locus in 26 cryopreserved MPNSTs.
  5. pmc Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1802, USA
    J Clin Endocrinol Metab 94:1826-34. 2009
    ..However, the prevalence of identifiable germline MEN1 mutations in familial MEN1 cases is only 70%. Some cases may have a germline mutation in another gene such as the p27 cyclin-dependent kinase inhibitor (CDKI)...
  6. ncbi Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas
    R G Weber
    Department of Human Genetics, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Oncogene 26:1088-97. 2007
    ..3 deletions involving the CDKN2A/p14(ARF)/CDKN2B loci in six tumors (60%)...
  7. doi Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
    M J Groenewoud
    Department of Molecular Cell Biology, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 51:1659-63. 2008
    ..Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects of six of these regions on insulin secretion as determined by a hyperglycaemic clamp...
  8. ncbi Repression of p15INK4b expression by Myc through association with Miz-1
    P Staller
    Institute of Molecular Biology and Tumour Research, Emil Mannkopff Strabetae 2, 35033 Marburg, Germany
    Nat Cell Biol 3:392-9. 2001
    ..Miz-1 upregulates expression of the cyclin-dependent kinases (CDK) inhibitor p15INK4b by binding to the initiator element of the p15INK4b promoter...
  9. ncbi Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma
    Nicholas Hearle
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
    Invest Ophthalmol Vis Sci 44:458-62. 2003
    ..and uveal melanomas in some families, coupled with the high frequency of somatic deletions of the INK4A-ARF locus in uveal melanomas, strongly suggests that mutations in P16(INK4A) and P15 account for a proportion of uveal melanomas.
  10. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8...
  11. ncbi Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population
    M Horikoshi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetologia 50:2461-6. 2007
    ..subunit associated protein 1-like 1 (CDKAL1), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B) and insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2), which had not been in the list of functional ..
  12. ncbi Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
    Shintaro Omori
    Laboratory for Diabetic Nephropathy, SNP Research Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Diabetes 57:791-5. 2008
    ....
  13. pmc Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    PLoS ONE 3:e2031. 2008
    ..Our aims were to validate these markers in other European and non-European populations, then to assess their combined effect in a large French study comparing T2D and normal glucose tolerant (NGT) individuals...
  14. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  15. pmc Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex
    Gobi Thillainadesan
    Department of Oncology, London Regional Cancer Program and The Lawson Health Research Institute, London, Ontario, Canada
    Mol Cell Biol 28:6066-77. 2008
    ..Our results establish p15(ink4b) as a direct target of the ZNF217 complex...
  16. pmc Type 2 diabetes risk alleles are associated with reduced size at birth
    Rachel M Freathy
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 58:1428-33. 2009
    ..We tested whether common genetic variants that predispose to type 2 diabetes also reduce birth weight...
  17. doi The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension
    Bjorn Wahlstrand
    Department of Medicine, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Hypertens 27:769-73. 2009
    ..We tested whether two single-nucleotide polymorphisms (SNPs) (rs2383207 and rs10757278), previously strongly associated with myocardial infarction, are independently associated with stroke and coronary events in patients with hypertension...
  18. pmc New common variants affecting susceptibility to basal cell carcinoma
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:909-14. 2009
    ..35, P = 2.1 x 10(-9)). A variant at 9p21 near CDKN2A and CDKN2B also confers susceptibility to BCC (rs2151280[C]; OR = 1.19, P = 6...
  19. doi Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque
    Lesca Miriam Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
    Atherosclerosis 214:264-70. 2011
    ..e. cyclin-dependent kinase inhibitors CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and methylthioadenosine phosphorylase (MTAP) were expressed in human ..
  20. pmc Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene
    Y Kotake
    Department of Biochemistry 1, Hamamatsu University School of Medicine, Shizuoka, Japan
    Oncogene 30:1956-62. 2011
    ..A 42 kb region on human chromosome 9p21 encodes for three distinct tumor suppressors, p16(INK4A), p14(ARF) and p15(INK4B), and is altered in an estimated 30-40% of human tumors...
  21. doi Prognostic significance of p14ARF, p15INK4b, and p16INK4a inactivation in malignant peripheral nerve sheath tumors
    Makoto Endo
    Departments of Anatomic Pathology and Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka Sanno Hospital, Fukuoka, Japan
    Clin Cancer Res 17:3771-82. 2011
    p14(ARF), p15(INK4b), and p16(INK4a) are tumor suppressor genes that are located closely at 9p21 and are often coinactivated by genetic or epigenetic alterations...
  22. ncbi Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer
    A Okamoto
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255
    Cancer Res 55:1448-51. 1995
    We examined the genomic status of cyclin-dependent kinase-4 and -6 inhibitors, p16INK4,p15INK4B, and p18, in 40 primary lung cancers and 31 metastatic lung cancers...
  23. ncbi p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    G J Hannon
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Nature 371:257-61. 1994
    ..2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced approximately 30-fold in human keratinocytes by treatment with TGF-beta, suggesting ..
  24. ncbi A cell cycle regulator potentially involved in genesis of many tumor types
    A Kamb
    Myriad Genetics, Inc, Salt Lake City, UT 84108
    Science 264:436-40. 1994
    ..Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues...
  25. ncbi Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer
    Kazuya Kudoh
    Department of Obstetrics and Gynecology, Self Defense Force Sendai Hospital, Miyagi 983 8580, Japan
    Int J Cancer 99:579-82. 2002
    To define the involvement of p16/CDKN2 and p15/MTS2 tumor-suppressor genes for response to chemotherapy in primary epithelial ovarian cancer, we analyzed alterations of the gene in 45 patients who were treated with primary cytoreductive ..
  26. ncbi Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage
    Michael Wanzel
    Institute for Molecular Biology and Tumor Research, University of Marburg, Emil Mannkopff Strasse 2, 35033 Marburg, Germany
    Nat Cell Biol 7:30-41. 2005
    ....
  27. ncbi Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:4968-76. 2005
    The purpose of this research was to compare methylation status and mRNA expression of p15INK4b and p16INK4a in serous epithelial ovarian cancer tissues and normal ovarian tissues.
  28. ncbi Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia
    Jasmine Healy
    Division of Hematology Oncology, Research Centre, Centro Hospitalo Universitaire Sainte Justine, Montreal, QC, Canada, H3T 1C5
    Blood 109:683-92. 2007
    ..of promoter single-nucleotide polymorphisms (pSNPs) in the cyclin-dependent-kinase inhibitor genes CDKN2A, CDKN2B, CDKN1A, and CDKN1B in the etiology of childhood pre-B acute lymphoblastic leukemia (ALL)...
  29. ncbi Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer
    Simon A Gayther
    Translational Research Laboratories, University College London, London, United Kingdom
    Cancer Res 67:3027-35. 2007
    ..in 13 genes involved in cell cycle control-CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, and CDKN2D-and risk of invasive epithelial ovarian cancer...
  30. pmc A common variant of the p16(INK4a) genetic region is associated with physical function in older people
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter EX2 5DW, UK
    Mech Ageing Dev 128:370-7. 2007
    p16(INK4a) is active in cell senescence, ageing and tumor suppression. Deletion of the small p16(INK4a)/ARF/p15(INK4b) region occurs in many cancers...
  31. ncbi Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a ..
  32. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
    ..to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk...
  33. ncbi A common variant on chromosome 9p21 affects the risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Science 316:1491-3. 2007
    ..The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance...
  34. pmc A common allele on chromosome 9 associated with coronary heart disease
    Ruth McPherson
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada
    Science 316:1488-91. 2007
    ..This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma ..
  35. ncbi Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
    Laura Pascoe
    Diabetes Research Group, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 56:3101-4. 2007
    ..studies have identified common, novel type 2 diabetes susceptibility loci within the FTO, CDKAL1, CDKN2A/CDKN2B, IGF2BP2, HHEX/IDE, and SLC30A8 gene regions...
  36. ncbi Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Denmark
    Diabetes 56:3105-11. 2007
    ..Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants...
  37. doi Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids
    K Duesing
    Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London, W12 0NN, UK
    Diabetologia 51:821-6. 2008
    Genome-wide association studies (GWASs) recently identified common variants in the CDKN2A/CDKN2B region on chromosome 9p as being strongly associated with type 2 diabetes...
  38. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  39. doi Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
    J K Hertel
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetologia 51:971-7. 2008
    ..To get a better estimation of the true risk conferred by these novel loci, we tested a completely unselected population of type 2 diabetes patients from a Norwegian health survey (the HUNT study)...
  40. pmc Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008
    ..However, the implications of these genes in Asians are unclear...
  41. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  42. doi Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies
    C Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 40:722-6. 2008
    ..We conclude that gene variants of CDKAL1, PPARG, IGF2BP2, HHEX, TCF7L2, and FTO predispose to type 2 diabetes in the German KORA 500 K study population. These associations appear to be independent of BMI...
  43. pmc Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population
    Ying Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 57:2834-42. 2008
    ..We aimed to replicate these observations in a population-based cohort of Chinese Hans and examine the associations of these variants with type 2 diabetes and diabetes-related phenotypes...
  44. pmc Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
    ..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
  45. doi Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles
    L Pascoe
    The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Diabetologia 51:1989-92. 2008
    ..The aim of this study was to test the cumulative effects of diabetes-risk alleles on measures of beta cell function in non-diabetic individuals...
  46. doi Common type 2 diabetes risk gene variants associate with gestational diabetes
    Jeannet Lauenborg
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:145-50. 2009
    ..We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci...
  47. pmc Susceptibility loci for intracranial aneurysm in European and Japanese populations
    Kaya Bilguvar
    Department of Neurosurgery, Neurobiology, Yale Center for Human Genetics and Genomics, Yale University School of Medicine, New Haven, CT 06510, USA
    Nat Genet 40:1472-7. 2008
    ..These findings have implications for the pathophysiology, diagnosis and therapy of intracranial aneurysm...
  48. doi Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population
    Y M Cho
    Department of Internal Medicine, College of Medicine, Seoul National University, 28 Yongon dong Chongno gu, Seoul 110 744, Korea
    Diabetologia 52:253-61. 2009
    ..The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM)...
  49. pmc Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
    Rong Rong
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 58:478-88. 2009
    In recent genome-wide association studies, variants in CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, CDKN2B, LOC387761, and FTO were associated with risk for type 2 diabetes in Caucasians...
  50. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  51. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  52. doi Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study
    X Lin
    Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
    Diabetologia 52:600-8. 2009
    ....
  53. pmc Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1
    Suchitra Basu
    Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA
    Proc Natl Acad Sci U S A 106:1433-8. 2009
    ..We report here an alternative mechanism by which Gfi-1 represses CDKN2B encoding p15(INK4B)...
  54. pmc Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:334-41. 2009
    ..SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk...
  55. pmc Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis
    Arne S Schaefer
    Institute for Clinical Molecular Biology, University Medical Center Schleswig Holstein, Kiel, Germany
    PLoS Genet 5:e1000378. 2009
    ..of the large antisense noncoding RNA ANRIL, which partly overlaps regulatory and coding sequences of CDKN2A/CDKN2B. A closely located diabetes-associated variant was independent of the CHD and periodontitis risk haplotypes...
  56. doi Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
    N Pulizzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetologia 52:825-9. 2009
    ....
  57. pmc Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:935-44. 2009
    ..CDKN2C, CDKN1A, CCND3, CCND1, CCND2, CDKN1B, CDK2, CDK4, RB1, CDKN2D, and CCNE1) and one gene region (CDKN2A-CDKN2B)...
  58. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  59. pmc Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:2129-36. 2009
    ..We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin secretion, and conversion of proinsulin to insulin...
  60. pmc Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
    Margaret Wrensch
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 41:905-8. 2009
    ..On 9p21, rs1412829 near CDKN2B had discovery P = 3.4 x 10(-8), replication P = 0.0038 and combined P = 1.85 x 10(-10). On 20q13...
  61. pmc Genome-wide association study identifies five susceptibility loci for glioma
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 41:899-904. 2009
    ..50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1...
  62. pmc Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2414-8. 2009
    ..In order to investigate whether type 2 diabetes risk-conferring alleles associate with low birth weight in our Caucasian childhood cohort, we examined the effects of 20 such loci on this trait...
  63. doi DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance
    Carmen Stanganelli
    Departamento de Genetica, Instituto de Investigaciones, Hematológicas Mariano R Castex, Academia Nacional de Medicina, J A Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina
    Ann Hematol 89:191-9. 2010
    ..We have analyzed methylation status of p15 INK4B , p16 INK4A , ARF, SOCS-1, p27 KIP1 , RASSF1A, and TP73 genes in bone marrow DNA samples from 21 MGUS and 44 MM ..
  64. pmc PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 4:e7643. 2009
    ..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism...
  65. pmc Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML
    Thomas A Paul
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4263, USA
    Blood 115:3098-108. 2010
    DNA hypermethylation of the p15INK4b tumor suppressor gene is commonly observed in acute myeloid leukemia (AML)...
  66. pmc Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression
    Michael S Cunnington
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 6:e1000899. 2010
    ..the association between 56 SNPs in this region and peripheral blood expression of the three nearest genes CDKN2A, CDKN2B, and ANRIL using total and allelic expression in two populations of healthy volunteers: 177 British Caucasians and ..
  67. pmc Genome-wide association study identifies five new breast cancer susceptibility loci
    Clare Turnbull
    Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:504-7. 2010
    ....
  68. pmc Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population
    Xueyao Han
    Department of Endocrinology and Metabolism, Peking University People s Hospital, Peking University Diabetes Center, no 11, XiZhiMen South Street, Beijing, China
    BMC Med Genet 11:81. 2010
    ..We aimed to determine the effects of these genetic loci associated with T2D in the Chinese Han population of China...
  69. doi A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
    ..53x10(-9), odds ratio (OR)=1.20), MDS1-EVI1 on 3q26 (rs6774494, Pcombined=1.34x10(-8), OR=0.84) and the CDKN2A-CDKN2B gene cluster on 9p21 (rs1412829, Pcombined=4.84x10(-7), OR=0.78)...
  70. pmc A genome-wide association study of optic disc parameters
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000978. 2010
    ..They revealed two genome-wide significant loci for VCDR, rs1063192 on chromosome 9p21 (p = 6.15x10(-11)) in the CDKN2B gene and rs10483727 on chromosome 14q22.3-q23 (p = 2.93x10(-10)) within 40 kbp of the SIX1 gene...
  71. pmc Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations
    Xiaohong Rose Yang
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD, USA
    Fam Cancer 9:625-33. 2010
    ..These genetic variants may, at least partially, exert their effects through nevi and tanning ability...
  72. pmc Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health
    Nikolay Popov
    Cell Proliferation Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Epigenetics 5:685-90. 2010
    The INK4b-ARF-INK4a locus encodes for two cyclin-dependent kinase inhibitors, p15(INK4b) and p16(INK4a) and a regulator of the p53 pathway, ARF. In addition ANRIL, a non-coding RNA, is also transcribed from the locus...
  73. doi Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals
    Yasuhito Ohsaka
    Department of Pharmacology, Chiba Institute of Science, Choshi, Chiba, Japan
    Biochem Genet 48:970-86. 2010
    Gene promoter regions of p15(INK4B), a cyclin-dependent kinase inhibitor, and phosphatase and tensin homolog (PTEN), a dual-function protein and lipid phosphatase, interact with regulatory factors for gene transcription and methylation...
  74. pmc Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk
    Christin E Burd
    The Curriculum in Toxicology, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS Genet 6:e1001233. 2010
    ..Although this locus encodes three well-characterized tumor suppressors, p16(INK4a), p15(INK4b), and ARF, the SNPs most strongly associated with ASVD are ∼120 kb from the nearest coding gene within a long ..
  75. doi Common genetic variants associated with open-angle glaucoma
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Mol Genet 20:2464-71. 2011
    ..The loci studied include ATOH7, CDC7/TGFBR3 and SALL1 for optic disc area, and CDKN2B, SIX1, SCYL1/LTBP3, CHEK2, ATOH7 and DCLK1 for VCDR...
  76. doi Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B
    Ada Congrains
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 220:449-55. 2012
    ..It is still not clear which of or how these transcripts are involved in the pathogenesis of atherosclerosis...
  77. doi TGF-β-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex
    Gobi Thillainadesan
    Department of Biochemistry, The University of Western Ontario, London, ON, Canada
    Mol Cell 46:636-49. 2012
    In this study we examine the mechanisms of dynamic DNA methylation of the p15(ink4b) tumor suppressor gene...
  78. pmc Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells
    Anna Motterle
    Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK
    Hum Mol Genet 21:4021-9. 2012
    ..This genomic region contains the CDKN2A and CDKN2B genes which encode the cell cycle regulators p16(INK4a), p14(ARF) and p15(INK4b) and the ANRIL gene which encodes ..
  79. pmc CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients
    Stuart D Horswell
    Medical Research Council, Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom
    J Lipid Res 54:3491-505. 2013
    ..Expression values for the cell-cycle inhibitor CDKN2B were increased, replicating data from an independent FCHL cohort...
  80. pmc Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population
    Kristy E Driver
    Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK
    Carcinogenesis 29:333-41. 2008
    ..evaluate 240 common SNPs found in the genes: CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKNIB, CDKN2A/CDKN2B, CDKN2C and CDKN2D...
  81. doi The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity
    Axel Haupt
    Medical Clinic, Department of Endocrinology, Metabolism, Nephrology and Angiology, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:1775-80. 2009
    ..We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an additive manner and whether their impact is influenced by insulin sensitivity...
  82. doi High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray
    Dong Yin
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Davis Building 5022 Room, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Mol Cancer Res 7:665-77. 2009
    ..Several signaling pathways were frequently abnormal. Either the p16(INK4A)/p15(INK4B)-CDK4/6-pRb or p14(ARF)-MDM2/4-p53 pathways were abnormal in 89% (49 of 55) of cases...
  83. ncbi Expression of cyclin-dependent kinase inhibitors during corneal wound repair
    J D Zieske
    Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Prog Retin Eye Res 19:257-70. 2000
    ..The CIP/KIP family includes p21, p27, and p57, while the INK4 family consists of p16. p15. p18. and pI9. At least five of these inhibitors are present in the corneal epithelium...
  84. ncbi Changes in gravity influence rat postnatal motor system development: from simulation to space flight
    K Walton
    Dept. of Physiology and Biophysics, NYU Medical Center 10016, USA
    Gravit Space Biol Bull 10:111-8. 1997
    ..R3. This 9-day mission (STS-72) included 2 litters at P5, P7, or P15 at launch. The P7-16 and P15-24 groups were studied post-flight...
  85. ncbi Mutations in adrenocortical tumors
    M Reincke
    Medical Department II, University of Freiburg, Germany
    Horm Metab Res 30:447-55. 1998
    ..carcinomas include mutations in the p53 tumor suppressor gene and rearrangements of the chromosomal locus 11 p15.5 associated with IGF II hyperexpression...
  86. ncbi Cell cycle regulators in bladder cancer: relationship to schistosomiasis
    Sanaa Eissa
    Oncology Diagnostic Unit, Medical Biochemistry Department, Ain Shams Faculty of Medicine, Cairo, Egypt
    IUBMB Life 56:557-64. 2004
    ..P16 (INK4A) and p15 (INK4B) are thought to act as tumor suppressors, since their inactivation and/or deletion are observable in various types ..
  87. ncbi The meiotic recombination hot spot created by the single-base substitution ade6-M26 results in remodeling of chromatin structure in fission yeast
    K Mizuno
    Cellular and Molecular Biology Laboratory, The Institute of Physical and Chemical Research, Wako, Saitama, Japan
    Genes Dev 11:876-86. 1997
    ..The mutation generates a meiosis-specific recombination hot spot and a binding site for the Mts1/Mts2 protein...
  88. ncbi Rare loss of heterozygosity of the MTS1 and MTS2 tumor suppressor genes in differentiated human thyroid cancer
    K M Schulte
    Dept. of General and Trauma Surgery, Heinrich Heine University, , Germany
    Horm Metab Res 30:549-54. 1998
    ..The low frequency of LOH in these types of thyroid cancer argues against a role of loss of heterozygosity at the MTS 1 and 2 gene locus in the development of differentiated thyroid neoplasia...
  89. ncbi Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family
    S Guran
    Department of Medical Biology, Gulhane Medical Academy, Ankara, Turkey
    Cancer Genet Cytogenet 113:145-51. 1999
    ..On the other hand, hereditary mutations of TP57KIP2, P15INK4B, and P16INK4A, which affect the cell cycle similar to TP53, were observed in some types of cancer...
  90. ncbi Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma
    A Iolascon
    Department di Biomedicina dell Età Evolutiva, University of Bari, Italy
    Hepatology 27:989-95. 1998
    ..Investigation at protein level confirmed the data obtained on RNA analysis. Indeed, p16INK4A and p15INK4B (products of expression of CDKN2A and CDKN2B respectively) were not observable while pl8INK4C (which is codified ..
  91. ncbi An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15INK4b and p16INK4a tumor suppressor genes
    M Malumbres
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Mamm Genome 9:183-5. 1998
    The cyclin-dependent kinase inhibitors p15INK4b and p16INK4a are involved in the development of a wide range of human and murine tumors...
  92. ncbi Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 19:2033-40. 2001
    To investigate the frequency of p15 and p16 gene promoter methylation in acute promyelocytic leukemia (APL), and to define its value in the detection of minimal residual disease (MRD) and treatment prognostication.
  93. ncbi Methylation of p15 and p16 genes in adult acute leukemia: lack of prognostic significance
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Cancer 91:2222-9. 2001
    Gene-promoter methylation is an epigenetic mechanism of transcription inactivation. In this study, the authors investigated the frequency and prognostic significance of p15 and p16 gene methylation in adult acute leukemia.
  94. ncbi Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK
    Susan Ceryak
    Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 255:139-49. 2004
    ..multi-transcript probe containing gene sequences for the cdk inhibitors, p21waf1/cip1, p27kip1, p16INK4a, p15INK4b; the pro-apoptotic proteins bcl-XS and bax; the anti-apoptotic proteins bcl-W, bcl-XL, and bcl2, GADD45, and ..
  95. ncbi Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma
    Bin Yang
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 18:412-20. 2005
    ..profiles of 12 candidate tumor suppressor genes (APC, E-cadherin/CDH1, MGMT, RASSF1A, GSTP, RAR-beta, p14ARF, p15INK4b, p16INK4a, p73, hMLH1 and DAPK) in 72 cases of cholangiocarcinoma, including equal number cases of intrahepatic ..
  96. pmc Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis
    E Latres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas Carlos III, 28220 Majadahonda, Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autónoma and Departamento de Patología Animal II, Facultad de Veterinar
    EMBO J 19:3496-506. 2000
    ..We report the generation of mice defective in P15(INK4b) and P18(INK4c)...
  97. ncbi Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2
    Nancy C Joyce
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:2152-9. 2002
    ..Cyclin-dependent kinase inhibitors (CKIs), such as p27kip1 and p15INK4b, help mediate mitotic inhibition in other cell types...
  98. ncbi p27kip1 Antisense-induced proliferative activity of rat corneal endothelial cells
    Michiharu Kikuchi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1763-70. 2004
    ..To determine whether antisense downregulation of p27(kip1) will overcome G(1)-phase arrest and promote cell cycle progression in rat corneal endothelial cells (CECs)...
  99. ncbi Deletions of p15 and p16 in schistosomal bladder cancer correlate with transforming growth factor-alpha expression
    Menha Swellam
    Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, Cairo, Egypt
    Clin Biochem 37:1098-104. 2004
    Cell proliferation is stimulated by growth factors and inhibited by p15 and p16 gene products...
  100. ncbi Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas
    M Malumbres
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York 10016, USA
    Oncogene 14:1361-70. 1997
    A wide panel of murine induced T-cell lymphomas have been analysed for p16INK4a or p15INK4b alterations...
  101. ncbi Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a
    R Baumgartner
    Max Planck Institute for Biochemistry D 82152, Martinsried, Federal Republic of Germany
    Structure 6:1279-90. 1998
    The four members of the INK4 gene family (p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d)) inhibit the closely related cyclin-dependent kinases CDK4 and CDK6 as part of the regulation of the G1-->S transition in the cell-division ..

Research Grants84

  1. Definition of chromosomal abnormalities by next generation sequencing
    Nara Sobreira; Fiscal Year: 2012
    ..already known to have translocations: the first (family L982181) is segregating an apparently balanced t(2;3)(p15;q12) translocation over 3 generations associated with craniofacial abnormalities;the second (patient JHU2010) has a ..
  2. Maintenance therapy with decitabine for acute myeloid leukemia in first remission
    William G Blum; Fiscal Year: 2010
    ..Many genes are frequently methylated in acute myeloid leukemia (AML) including p15, estrogen receptor (ER), and calcitonin, among others...
  3. Randomized study of combined epigenetic therapy
    Jean Pierre J Issa; Fiscal Year: 2011
    ..Responses were associated with P15 induction, and patients with the highest levels of P15 after treatment were most likely to achieve a CR...
  4. MAPPING SURFACE CONTACTS IN BIOMACROMOLECULE COMPLEXES
    Alan Marshall; Fiscal Year: 2000
    ..The INK4 family of tumor suppressor proteins (p15,p16,p18,p19) acts in part by forming non-covalent complexes with cyclin-dependent kinases (cdk, 34-37 kDa), and ..
  5. P16 GENE FAMILY IN HEALTH AND DISEASE
    Gregory Hannon; Fiscal Year: 1999
    ..The p16 family currently contains two members, p16INK4A and p15INK4B. The p15 and p16 genes are tandemly arrayed at a site of frequent chromosomal abnormality in human tumors (9p21), ..
  6. 5-Azacytidine and MS-275 in Myeloid Malignancies
    Steven Gore; Fiscal Year: 2005
    ..used to monitor the expression of two genes which are most commonly silenced through methylation in AML and MDS: p15INK4B and Ecadherin (E-CAD)...
  7. Joan Massague; Fiscal Year: 2014
    ..the role of FOXO and C/EBPb transcription factors as Smad co-regulators of cytostatic genes responses (p21CIP1, p15INK4B and MYC gene responses)...
  8. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
    ..IA cases and controls, we have replicated the recent findings for SNPs in the regions of chromosome 9 (CDKN2A and CDKN2B closest genes) and 8 (SOX17 closest gene) but not chromosome 2...
  9. TUBA FEHR; Fiscal Year: 2015
    ..I will investigate twitcher tissue at progressive stages of the disease (P7, P15, P30) and also test for a synergistic effect by adding varying concentrations of psychosine in VEGF-induced ..
  10. NICHOLAS JAMES LEEPER; Fiscal Year: 2014
    ..Proposed experiments will build on preliminary work which has implicated the cell- cycle regulatory gene, CDKN2B, as the causative gene responsible for clinical disease...
  11. Susan Bonner-Weir; Fiscal Year: 2015
    ..patterns of islet gene expression, most with striking inflection points between P7 and 9 days and again about P15. While we have shown that adenoviral-mediated expression of MafA induced glucose- stimulated insulin secretion (..
  12. Promoter Specific Hypermethylation Sensors for Early Cancer Detection
    Indraneel Ghosh; Fiscal Year: 2011
    ..in model DNA constructs;and 2) designing and testing biosensors that target promoter regions of genes (BRCA1, CDH1, p15, p16, MGMT, GSTp1) implicated in cancer...
  13. Identification and study of the vascular disease gene at 9p21.3
    Thomas Quertermous; Fiscal Year: 2013
    ..Compelling recent evidence now suggests that a cyclin-dependent kinase inhibitor gene, CDKN2B, and a non-coding antisense RNA in the CDKN2B locus named ANRIL, are the most likely candidate genes linked to the ..
  14. DEBORAH JEAN WATSON; Fiscal Year: 2014
    ..that the local organization of dendritic SER becomes more elaborate as spine density and synapse size increase from P15 to P21...
  15. Elliott D Kieff; Fiscal Year: 2016
    ..2. Determine the mechanisms through which EBNA3A and EBNA3C suppress p16, p14, (and p15) expression using conditional EBNA3A and 3C LCLs and time course studies of RBL infection. 3...
  16. Margaret R Wrensch; Fiscal Year: 2015
    ..region in chromosome 9p21 (commonly deleted in glioblastoma) suggest a role for variation in the cell cycle gene CDKN2B in gliomagenesis...
  17. Ontogeny of Response to Ethanol After Prenatal Ethanol
    Norman E Spear; Fiscal Year: 2010
    ..and ethanol reinforcement in adolescence and at a point midway between birth and adolescence (postnatal day 15, P15)...
  18. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2001
    ..TGF-b events are blocked by the presence of BF-1- hyperphosphorylation of retinoblastoma, block of induction of p15 mRNA levels, and block of activation of reporter genes driven by a TGF-b- responsive promoter...
  19. In Vivo Analysis of a Noncoding Susceptibility Region for Coronary Artery Disease
    LEN ALEXANDER PENNACCHIO; Fiscal Year: 2010
    ..from the mouse genome and show that it significantly impacts on cardiac expression of two genes (Cdkn2a and Cdkn2b) adjacent to the deletion...
  20. JASON BOKE WRIGHT; Fiscal Year: 2014
    ..Furthermore, non-coding polymorphisms in the CKN2A/CDKN2B locus (9p21) reproducibly correlate with the disease...
  21. Todd A Waldman; Fiscal Year: 2016
    ..mechanism for activation of cdk4/6 in GBM is homozygous deletion of the INK4 locus (containing the p16INK4a and p15INK4b genes)...
  22. TGF-BETA RECEPTOR SIGNALING IN TRANSFORMED CELLS
    Harvey Lodish; Fiscal Year: 2001
    ..and/or apoptosis, (ii) that stimulate expression, in the absence of TGF-beta, of specific promoters, JunB, PAI, p15, and/or p21 - that are normally induced by TGF-beta in cells we are using, and (iii) that abolish the ability of ..
  23. ETIOLOGY OF EARLY BREAST MALIGNANCY
    E Greenberg; Fiscal Year: 1999
    ..Blocks will be analyzed, using PCR techniques, for the alteration of cancer-related genes p16 and p15 on chromosome 9p, and for extent and frequency of loss of heterozygosity on chromosome 11...
  24. ADOPTIVE TRANSFER OF CD8+ CTLS TO CONTROL EIAV
    ROBERT MEALEY; Fiscal Year: 2001
    ..If the foals are protected, the protective effects of CD8+ CTLs specific for the conserved Gag proteins p15, p26a, and p26b will be evaluated...
  25. ASBESTOS AND NO2 IN ENVIRONMENTAL LUNG DISEASE
    Nicholas Heintz; Fiscal Year: 2001
    ..Activation of cyclin-dependent kinases (CDKs), metabolism of their protein inhibitors (i.e., CKIs p15, pl6, pl8, p2l, and p27),and phosphorylation of retinoblastoma family proteins (pRB and pl3O) will be studied as ..
  26. FUNCTION AND DYSFUNCTION IN HUMAN ANTITHROMBINS
    PETER GETTINS; Fiscal Year: 2007
    ..in promoting the conformational change in the heparin binding[unreadable] site that results in expulsion of P15 and P14 residues of the reactive[unreadable] center loop...
  27. NUDR--A Potential Tumor Suppressor of Childhood Cancers
    Jodi Huggenvik; Fiscal Year: 2005
    ..NUDR maps to the precise chromosomal region (11 p15.5) harboring multiple tumor suppressors for lung, liver, Wilms', and possibly many other cancers...
  28. DISTRIBUTION OF IRON AND HEME BY PROTEINS
    URSULA MULLER EBERHARD; Fiscal Year: 1993
    ..5 kDa vs 14 kDa) has also been identified, named p15.5, and found to localize in euchromatin-containing regions of the nucleus and nucleolus. We are proposing: I...
  29. BWS AND EMBRYONAL TUMOR SUPPRESSOR GENES ON 11P15
    ANDREW FEINBERG; Fiscal Year: 2009
    ..We earlier mapped BWS to a region of 11 p15 containing an unidentified WT gene (WT2) lost in WT and common adult cancers...
  30. STRUCTURE/FUNCTION OF HSV1 ICP4
    Neal Deluca; Fiscal Year: 2003
    ..In addition, ICP4 possesses a domain with structural and functional similarity to a cellular co-activator, p15. p15 facilitates TFIID and TFIIA complex formation on promoters and regulates the activity of transcription ..
  31. Mechanism of Retinoid Inhibition of Oral SCC Cell Growth
    KENNETH SOPRANO; Fiscal Year: 2004
    ..p107), cyclins (Dl, D2, D3), cdks (cdk2, cdk4, cdk6) and cdk inhibitors (p15, p16, p21, p27)...
  32. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2009
    ..progression) and find that these positive and negative regulators act largely by controlling levels of the cdk inhibitory protein, p27kip1...
  33. MECHANISM OF INSULIN ACTION
    M Lane; Fiscal Year: 1990
    ..o the role of phosphorylation of p15 (422 protein) by the receptor kinase in insulin-stimulated glucose uptake and in other actions of insulin...
  34. Cell Cycle Regulation and Leukemogenesis by CBFb-SMMHC
    Alan Friedman; Fiscal Year: 2007
    ..Aim 2: To determine whether CBFbeta-SMMHC and loss of p15INK4b cooperate to induce AML, whether loss of p15 specifically affects myeloid progenitor proliferation, and whether ..
  35. IMMUNOLOGIC & MOLECULAR MARKERS FOR DIAGNOSIS/PROGNOSIS
    Yves Fradet; Fiscal Year: 1999
    ..initial focus will be on detailed analysis of chromosome 9 by microsatellite and by standard RFLP for the p16 and p15 genes which are suspected to be frequently altered in Ta tumors...
  36. STUDY ON DEVELOPMENT & ASSESSMENT OF RETROVIRAL VACCINES
    William Green; Fiscal Year: 1993
    ..the lethality of retroviruses such as HIV, and due to the presence of inhibitory determinants or molecules such as p15(E) in murine retroviruses...
  37. Genomic Imprinting and Embryonic Development
    Laurie Jackson Grusby; Fiscal Year: 2009
    ..The molecular basis for these diseases is deregulation of imprinted gene clusters on 11 p15 and 15q11 caused predominantly by either deletions within imprinting control centers (ICC) or by epigenetic DMA ..
  38. STRUCTURE/FUNCTION STUDIES WITH HIV RIBONUCLEASE H
    STUART LE GRICE; Fiscal Year: 1993
    ..Using a novel metal chelate affinity resin, several forms of the genetically engineered 15 kDa RNaseH domain (p15 RNaseH) will be purified and characterized...
  39. MAPPING THE TREACHER COLLINS SYNDROME LOCUS
    ETHYLIN JABS; Fiscal Year: 1990
    ..of this condition and a de novo, interstitial deletion of the short arm of chromosome 4 (46,XY,del(4)(pter->p15.2::p14->qter)) has recently been found...
  40. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 2006
    ..This hypothesis will be tested in P15 rats and in adult mice subjected to status epilepticus induced by lithium and pilocarpine or by kainic acid...
  41. The 5-HT1A Receptor and Brain Development
    Probal Banerjee; Fiscal Year: 2005
    ..hippocampal slice cultures from mice, activation of Erk1/2 was dependent on an unidentified PKC isozyme, whereas at P15, PKCa was activated by Erk1/2 in 5-HT1A-R signaling...
  42. Direct Detection of Hypermethylation in Cancer
    Indraneel Ghosh; Fiscal Year: 2007
    ..specific methylation events in model DNA constructs; and 2) designing and testing biosensors that target promoter regions of genes (BRCA1, CDH1, p15, p16, MGMT, GSTp1) implicated in cancer. [unreadable] [unreadable] [unreadable]
  43. REGULATION OF MEIOTIC DEVELOPMENT BY MTS1-MTS2 PROTEIN
    WAYNE WAHLS; Fiscal Year: 2004
    ..Dr. Wahls and colleagues purified a heterodimeric protein, Mts1-Mts2-M26 complex serves as an enhancer of recombination...
  44. MOLECULAR GENETIC LESIONS AND CLINICAL OUTCAME IN ALL
    URSULA KEES; Fiscal Year: 2000
    ..The two aims are, firstly, to examine the prognostic significance of deletion of the p15, p16 and p19ARF genes for a cohort of 300 pediatric patients treated on three CCG (Children's Cancer Group) ..
  45. THE JAZF1 AND 2 GENES IN UTERINE SARCOMAS
    Jeffrey Sklar; Fiscal Year: 2005
    ..and 2, which are fused in low grade endometrial stromal sarcomas (ESSs) as a consequence of a recurrent (7;17)(p15;q21) chromosomal translocation associated with these tumors...
  46. Behavioral state development in infants
    Mark Blumberg; Fiscal Year: 2009
    ..contribute to sleep cycle development between P2 and P8, as well as a second transition that occurs between P10 and P15. This second transition covers a period characterized by the development of slow-wave sleep (SWS), the second major ..
  47. MOLECULAR PATHOGENESIS OF MALIGNANT MELANOMA
    Lynda Chin; Fiscal Year: 2002
    ..Specifically, I will focus on the differential roles of p15 INK4b, P16INK4a and p19ARF as well as activated H-rasva112 in development of malignant melanoma...
  48. PROLIFERATIVE EFFECTS OF CDK4 AND CDK6 DYSREGULATION
    Philip Hinds; Fiscal Year: 2001
    ..In this system overexpression of cdk4/6 also leads to overproduction of the cell cycle inhibitors, p15 and possibly p16. Understanding the mechanism by which induction of p15 occurs is the first specific aim...
  49. TGF-BETA SIGNALING PATHWAY AND CELL GROWTH REGULATION
    Xiao Fan Wang; Fiscal Year: 2000
    ..through the activation and/or upregulation of several cyclin- dependent kinase inhibitors (cdkI's), including p21, p15, and p27...
  50. ROLE AND REGULATION OF CDK4 IN THE NORMAL LENS
    Ronald DePinho; Fiscal Year: 2000
    ..g. p15/INK4 and p16INK4) modulatory proteins...
  51. Role of Smad proteins in cell growth regulation
    Fang Liu; Fiscal Year: 2006
    ..For example, Smad proteins have been shown or implicated to upregulate the expression of CDK inhibitors p21 and p15, and downregulate the expression of the c-myc protooncogene...
  52. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..Finally, we will examine the relationships among the level of arousal, post-conceptional age, sleep state, and other infant behaviors such as feeding that are also associated with changes in autonomic activity. ..
  53. RESPIRATORY SYSTEM INTEGRATION BY THE BRAINSTEM
    ALBERT BERGER; Fiscal Year: 2002
    ..We hypothesize that ethanol increases the affinity of glycine-Rs for glycine and thereby potentiates inhibitory synaptic events. This may be an important mechanism whereby alcohol consumption exacerbates obstructive sleep apnea. ..
  54. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    Sarah F Leibowitz; Fiscal Year: 2010
    ..In summary, this grant tests the novel hypothesis that a high-fat diet itself can promote overeating and ultimately dietary obesity through a positive feedback loop involving circulating lipids, hypothalamic peptides and accumbens DA. ..
  55. Defining an Obesity QTL on Chromosome 3q
    Xiaofeng Zhu; Fiscal Year: 2007
    ..The methodologies applied have been used successfully to identify unique sequence variants in linkage peaks and to conduct fine mapping with specific physiologic candidate genes. ..
  56. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2007
    ..Pharmacologic modulation of persistent inflammation triggered by biopersistent, carcinogenic fibers may provide a new strategy to prevent progression of malignant mesothelioma in exposed populations. ..
  57. Mechanism of combined 'epigenetic therapy' in myeloid malignancies
    Steven Gore; Fiscal Year: 2009
    ....
  58. Arsenic Trioxide in Primary Curative APL Therapy
    Steven Gore; Fiscal Year: 2008
    ..Success of this trial will potentially be followed by the testing of regimen against more conventional and more extensive treatment for APL in a Phase III trial. [unreadable] [unreadable] [unreadable]..
  59. Dopamine and Exploration in Development
    Gregory Goodwin; Fiscal Year: 2004
    ....
  60. Akt Inhibitors to Treat Ewing's Sarcoma
    Jeffrey Toretsky; Fiscal Year: 2005
    ..Our findings from this Phase I Sun will hopefully lead to a key compound that can be further developed in a Phase II STTR ultimately leading to clinical trials in patients with ESFT. ..
  61. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
  62. DNA Methylation in Colon Cancer Metastasis
    Jean Pierre Issa; Fiscal Year: 2008
    ..abstract_text> ..
  63. Ethanol, neurotrophins, and thalamocortical matching
    SANDRA MOONEY; Fiscal Year: 2006
    ..abstract_text> ..
  64. Molecular Stratification of Brain Tumors
    John Cowell; Fiscal Year: 2005
    ..Ultimately we will be able to develop a custom array which will allow an unbiased analysis of brain tumors in an attempt to predict clinical phenotypes such as response to therapy and prognosis. ..
  65. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
    ..first, middle) The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  66. EIAV vector targeting dendritic cells to induce CTL
    ROBERT MEALEY; Fiscal Year: 2005
    ..Thus, this proposal will test the hypothesis that targeting dendritic cells in vivo with an EIAV vector will induce CTL in horses to multiple viral proteins. ..
  67. Cell Cycle Controlling Genes in Adult Acute Lymphoma
    Guillermo Garcia Manero; Fiscal Year: 2005
    ..or indirectly in cell cycle control appear to be particularly targeted in this disease, with methylation of p73, p15 or p57KIP2 occurring in 11% to 34% of patients...
  68. Enhancements to a human embryo, serial-section database
    ROBERT CORK; Fiscal Year: 2007
    ..Any such improvement in general levels of understanding about human development can only improve the reproductive health of our population and levels ofpre- and post-natal care. ..
  69. Inositol defects and neuronal death in the weeble mouse
    Arne Nystuen; Fiscal Year: 2004
    ..Together these aims will provide an understanding of precisely where, when and why neurons are lost due to the loss of Inpp4a function. ..
  70. Development of SL-101, An Immunotoxin that Targets Cancer Stem Cells
    Malcolm Moore; Fiscal Year: 2006
    ..This Phase I STTR grant will cover the development of SL-101 through key phases of pre-clinical development. [unreadable] [unreadable] [unreadable]..
  71. Serum Vitamin D and Mortality from Eye Melanoma
    Kathleen Egan; Fiscal Year: 2007
    ..If the proposed hypotheses are supported, findings may offer novel insights, and point to new strategies for cancer control. [unreadable] [unreadable] [unreadable]..
  72. REGULATION OF ORNITHINE DECARBOXYLASE BY PHORBOL ESTERS
    Andrew Butler; Fiscal Year: 2002
    ..Taken together, these studies should provide new insight into the mechanisms by which tumor promoters and oncogenes influence ODC regulation and corrupt patterns of gene expression during carcinogenesis. ..
  73. Biacore T100
    Jeffrey Toretsky; Fiscal Year: 2006
    ..These enhanced capabilities of the T100 will allow projects investigating many types of biologic processes to advance. ..
  74. Identification of Green Tea Polyphenol-Targeted Genes
    Stephen Hsu; Fiscal Year: 2004
    ..Data generated from this proposal may reveal novel drug targets for treatment of head and neck cancer. ..
  75. EIAV Control by DNA Vaccine-Induced CTL
    ROBERT MEALEY; Fiscal Year: 2006
    ..Importantly, four CTL epitope clusters occur in the p15 matrix and p26 capsid proteins of Gag...
  76. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 2004
    ....
  77. Neoplasia and Methylated CpG Islands Amplification
    Jean Pierre Issa; Fiscal Year: 2004
    ..Ultimately, methylation profiling may prove very valuable in identifying subsets of patients with distinct clinical courses and response to specific therapeutic interventions, including using methylation inhibitors. ..
  78. Control of SnoN Activity by SUMO modification
    Xia Lin; Fiscal Year: 2006
    ..Finally, the results may also provide a foundation for the rational design of novel therapeutic approaches for prevention and treatment of cancer and musculoskeletal diseases. [unreadable] [unreadable]..
  79. Lipid Imbalance in CF: Potential CFTR Dysfunction
    Julie Hoover Fong; Fiscal Year: 2006
    ..abstract_text> ..
  80. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  81. P21 transcriptional inhibitors as proapoptotic compounds
    Andrei Gartel; Fiscal Year: 2003
    ..This study may improve treatment of cancer by leading to the identification of new compounds that will increase the efficiency of cell death promoting anticancer drugs for cancer treatment. ..
  82. Growth regulatory targets of the Tuberous Sclerosis Complex
    ROBERT NEIL EISENMAN; Fiscal Year: 2010
    ..Such genes are expected to be effectors of deregulated cell growth in tuberous sclerosis, and as such constitute potential targets for diagnosis and treatment of the disease. ..
  83. Diet and DNA methylation in colon mucosa and adenomas
    Jean Pierre Issa; Fiscal Year: 2007
    ..These studies should provide definitive information on interactions between diet and DNA methylation in human colorectal mucosa and cancer. [unreadable] [unreadable]..