CELA1

Summary

Gene Symbol: CELA1
Description: chymotrypsin like elastase family member 1
Alias: ELA1, chymotrypsin-like elastase family member 1, elastase 1, pancreatic, elastase-1, pancreatic elastase 1
Species: human

Top Publications

  1. ncbi The interaction of alpha-1-antitrypsin with chymotrypsin, trypsin and elastase
    A B Cohen
    Biochim Biophys Acta 391:193-200. 1975
  2. pmc The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells
    Masatsugu Masuda
    Departments of Surgery Otolaryngology, UCSD School of Medicine, La Jolla, CA, 92093, USA
    Mol Neurobiol . 2016
  3. doi Inverse association of HbA1c with faecal elastase 1 in people without diabetes
    Wolfgang Rathmann
    Institute for Biometrics and Epidemiology, German Diabetes Center, Dusseldorf, Germany Electronic address
    Pancreatology 15:620-5. 2015
  4. doi Transcriptional programs regulated by both LEAFY and APETALA1 at the time of flower formation
    Cara M Winter
    Department of Biology, Duke University, Durham, NC, 27708, USA
    Physiol Plant 155:55-73. 2015
  5. doi A mechanically sensitive cell layer regulates the physical properties of the Arabidopsis seed coat
    Audrey Creff
    Laboratoire Reproduction et Développement des Plantes RDP, ENS de Lyon CNRS UMR 5667 INRA UMR 879 UCBL, 46 allee d Italie, 69364 Lyon, France
    Nat Commun 6:6382. 2015
  6. doi Extract of the mycelium of T. matsutake inhibits elastase activity and TPA-induced MMP-1 expression in human fibroblasts
    So Young Kim
    Major in Biomedical Science, Department of Medicine, Graduate School, Chung Ang University, Seoul, Republic of Korea
    Int J Mol Med 34:1613-21. 2014
  7. pmc NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy
    D Toncheva
    Department of Medical Genetics, Medical University of Sofia, Zdrave Street 2, 1431 Sofia, Bulgaria Genomics Laboratory of Malinov Clinic, 1620 Sofia, Bulgaria
    Biomed Res Int 2014:920723. 2014
  8. doi Nutritional status, fecal elastase-1, and 13C-labeled mixed triglyceride breath test in the long-term after pancreaticoduodenectomy
    Cinara Knychala Muniz
    From the Medical Nutrition Discipline, Department of Internal Medicine, Biliary Tract and Pancreas Group, Department of Surgery, and Division of General Internal and Geriatrics Medicine, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Pancreas 43:445-50. 2014
  9. doi The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies
    Gitta Maria Seleznik
    Swiss HPB Hepato Pancreato Biliary Center, University Hospital Zurich, Switzerland
    Cytokine Growth Factor Rev 25:125-37. 2014
  10. pmc Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells
    Sylvie Rato
    URIA Centro de Patogénese Molecular, Faculdade de Farmacia, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 5:e9276. 2010

Research Grants

  1. Miklos Sahin-Toth; Fiscal Year: 2016

Scientific Experts

  • Wolfgang Rathmann
  • G H Swift
  • R J MacDonald
  • Nils Ewald
  • J Teichmann
  • C Edelstein
  • A Cade
  • Antti Hietaranta
  • Miklos Sahin-Toth
  • Masatsugu Masuda
  • Audrey Creff
  • Cara M Winter
  • D Toncheva
  • So Young Kim
  • Cinara Knychala Muniz
  • Gitta Maria Seleznik
  • Marcus D Wilson
  • Luigi Benini
  • S D Rose
  • Wayne Young
  • Yingying Zhang
  • Sylvie Rato
  • Renata I Dmitrieva
  • Ibane Abasolo
  • Mette Vesterhus
  • R C Wilmouth
  • Jan Uwe Hahn
  • Kumi O Kuroda
  • Anthony D Bird
  • Balazs Ribar
  • Francisco X Real
  • Pilar Navarro
  • Edit Szepessy
  • J M Seubert
  • Susana Aguilar
  • Franco Cavalot
  • Kwang Pak
  • Allen F Ryan
  • Lina Mullen
  • Yan Li
  • Eduardo Chavez
  • Lysiane Brocard
  • Nobutoshi Yamaguchi
  • Miin Feng Wu
  • Doris Wagner
  • Gwyneth Ingram
  • V Djonov
  • Rolf Graf
  • Eduardo Ferrioli
  • L Balabanski
  • S Ivanov
  • M Polenakovic
  • V Stefanovic
  • R Staneva
  • Rafael Kemp
  • L Jankovic-Velickovic
  • D Serbezov
  • Tomohiko Okuda
  • Mathias Heikenwalder
  • Tracy O'Connor
  • Eun Joo Kim
  • V Simeonov
  • Yeon Su Jeong
  • P Dimitrov
  • Karina Pfrimer
  • A Galabov
  • José Sebastião dos Santos
  • V Djordjevic
  • Beom Joon Kim
  • T Jevtovic-Stoimenov
  • R Vazharova
  • M Mihailova-Hristova
  • R Cukuranovic
  • S Karachanak
  • Yi Seop Song
  • D Plaseska-Karanfilska
  • Selma Freire Cunha
  • I Dimova
  • Kyung Chan Go
  • Julio Sergio Marchini
  • Jessica Zöller
  • M Malinov
  • Chiara Cristofori
  • Rocco Micciolo
  • Michelle Harreman
  • Italo Vantini
  • Hediye Erdjument-Bromage
  • Luca Frulloni
  • James Reid
  • Flora Agugiaro

Detail Information

Publications55

  1. ncbi The interaction of alpha-1-antitrypsin with chymotrypsin, trypsin and elastase
    A B Cohen
    Biochim Biophys Acta 391:193-200. 1975
    ..The variable susceptibility of the enzyme to blockage of the inhibition by low concentrations of p-dioxane suggested that hydrophobic bonds may be important in the interaction with alpha-1-antitrypsin...
  2. pmc The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells
    Masatsugu Masuda
    Departments of Surgery Otolaryngology, UCSD School of Medicine, La Jolla, CA, 92093, USA
    Mol Neurobiol . 2016
    ..When the region from 1 to 0.4 kb was replaced with the minimal promoter of the Ela1 gene, HC expression was maintained but at a drastically reduced level...
  3. doi Inverse association of HbA1c with faecal elastase 1 in people without diabetes
    Wolfgang Rathmann
    Institute for Biometrics and Epidemiology, German Diabetes Center, Dusseldorf, Germany Electronic address
    Pancreatology 15:620-5. 2015
    Faecal elastase 1 (FE1) was inversely correlated with diabetes duration and HbA1c in type 2 diabetes. The association of FE1 and HbA1c has not been investigated in people without diabetes.
  4. doi Transcriptional programs regulated by both LEAFY and APETALA1 at the time of flower formation
    Cara M Winter
    Department of Biology, Duke University, Durham, NC, 27708, USA
    Physiol Plant 155:55-73. 2015
    ..Finally, we show that the gibberellin catabolism enzyme ELA1, which was recently shown to be important for the timing of the switch to flower formation, is positively feedback-..
  5. doi A mechanically sensitive cell layer regulates the physical properties of the Arabidopsis seed coat
    Audrey Creff
    Laboratoire Reproduction et Développement des Plantes RDP, ENS de Lyon CNRS UMR 5667 INRA UMR 879 UCBL, 46 allee d Italie, 69364 Lyon, France
    Nat Commun 6:6382. 2015
    ..microtubule dynamics consistent with mechanical stress perception and shows mechanosensitive expression of ELA1, a regulator of seed size and gibberellic acid (GA) metabolism...
  6. doi Extract of the mycelium of T. matsutake inhibits elastase activity and TPA-induced MMP-1 expression in human fibroblasts
    So Young Kim
    Major in Biomedical Science, Department of Medicine, Graduate School, Chung Ang University, Seoul, Republic of Korea
    Int J Mol Med 34:1613-21. 2014
    ..Our data suggest that the extract of the mycelium of T. matsutake may prove to be an effective biomaterial for anti-wrinkle treatment, as it can obstruct the degradation of the dermal ECM...
  7. pmc NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy
    D Toncheva
    Department of Medical Genetics, Medical University of Sofia, Zdrave Street 2, 1431 Sofia, Bulgaria Genomics Laboratory of Malinov Clinic, 1620 Sofia, Bulgaria
    Biomed Res Int 2014:920723. 2014
    ..than 40% frequency in both patients' groups, we nominated 3 genes with possible deleterious/damaging variants--CELA1, HSPG2, and KCNK5...
  8. doi Nutritional status, fecal elastase-1, and 13C-labeled mixed triglyceride breath test in the long-term after pancreaticoduodenectomy
    Cinara Knychala Muniz
    From the Medical Nutrition Discipline, Department of Internal Medicine, Biliary Tract and Pancreas Group, Department of Surgery, and Division of General Internal and Geriatrics Medicine, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Pancreas 43:445-50. 2014
    ..This study aimed to compare the body composition, dietary intake and serum levels of vitamins and minerals, and exocrine pancreatic function in patients late after pancreaticoduodenectomy (PD) and healthy subjects...
  9. doi The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies
    Gitta Maria Seleznik
    Swiss HPB Hepato Pancreato Biliary Center, University Hospital Zurich, Switzerland
    Cytokine Growth Factor Rev 25:125-37. 2014
    ..g. acinar cells). Expression of LT α and β on acinar cells in murine pancreata Tg(Ela1-Lta,b) mice led to chronic pancreatitis and sufficed to reproduce key features of human AIP including the ..
  10. pmc Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells
    Sylvie Rato
    URIA Centro de Patogénese Molecular, Faculdade de Farmacia, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 5:e9276. 2010
    ..This study brings new insights for the complex interplay of HIV-1/host cell and opens new possibilities for antiviral strategies...
  11. ncbi Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution
    M Tsunemi
    Peptide Institute Inc, Protein Research Foundation, Osaka, Japan
    Biochemistry 35:11570-6. 1996
    ..This intramolecular hydrogen bond network and the network of four disulfide bonds might play a significant role in stabilizing the conformation of the binding site for expressing the potent specific inhibitory activity...
  12. pmc Changes in bowel microbiota induced by feeding weanlings resistant starch stimulate transcriptomic and physiological responses
    Wayne Young
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Appl Environ Microbiol 78:6656-64. 2012
    ..with changes in colonic short-chain fatty acid (SCFA) concentrations, colonic-tissue gene expression (Gsta2 and Ela1), and host physiology (serum metabolite profiles and colonic goblet cell numbers)...
  13. doi Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection
    Luigi Benini
    Gastroenterology Unit, Department of Medicine, University of Verona, Policlinico G B Rossi, Piazzale Scuro 10, 37134 Verona, Italy
    Pancreatology 13:38-42. 2013
    ....
  14. pmc Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress
    Marcus D Wilson
    Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms EN6 3LD, UK
    Cell 154:983-95. 2013
    ..a ubiquitin-binding domain to recruit the Elongin-Cullin E3 ligase complex via a ubiquitin-homology domain in the Ela1 protein. This facilitates polyubiquitylation of Rpb1, triggering its proteasome-mediated degradation...
  15. ncbi Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase
    N K Honey
    Somat Cell Mol Genet 10:369-76. 1984
    ..hybridization methods for the segregation of the genes for trypsin-1 (TRY1), chymotrypsin B (CTRB), and elastase-1 (ELA1). TRY1 was assigned to human chromosome 7q22----qter, CTRB to chromosome 16, and ELA1 to chromosome 12...
  16. ncbi Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats
    J M Seubert
    Division of Intramural Research, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Renal Physiol 289:F552-61. 2005
    ..Conversely, elastase 1 (Ela1) was found to be the predominant gene downregulated in SHR at both time points...
  17. pmc Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression
    Susana Aguilar
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Dr Aiguader, 80, 08003 Barcelona, Spain
    Am J Pathol 165:1129-39. 2004
    ..Transgenic mice expressing T antigen and c-myc under the control of the elastase promoter (Ela1-TAg and Ela1-myc, respectively) were used...
  18. ncbi Analyses of differential gene expression in genetic hypertensive rats by microarray
    Tomohiko Okuda
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Hypertens Res 25:249-55. 2002
    ..genes (6 up-regulated genes: SAH, Hsp70, MCT1, RBP, IDI1, Prion; and 5 down-regulated genes: Thrombin, Dyn, SOD3, Ela1, Gst Y(b)) and subjected them to an F2 cosegregation analysis...
  19. doi Two Arabidopsis cytochrome P450 monooxygenases, CYP714A1 and CYP714A2, function redundantly in plant development through gibberellin deactivation
    Yingying Zhang
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Plant J 67:342-53. 2011
    ..The Arabidopsis genome contains a tandemly duplicated gene pair ELA1 (CYP714A1) and ELA2 (CYP714A2) that encode EUI homologs...
  20. pmc Genome-wide identification of allelic expression in hypertensive rats
    Renata I Dmitrieva
    Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center, 2121 Holcombe Blvd, Houston, TX 77030, USA
    Circ Cardiovasc Genet 2:106-15. 2009
    ..Inbred animal models can facilitate genetic studies of disease traits. The spontaneously hypertensive rat (SHR) is an inbred model of hypertension that exists in several closely related but genetically distinct lines...
  21. doi FDG PET imaging of Ela1-myc mice reveals major biological differences between pancreatic acinar and ductal tumours
    Ibane Abasolo
    Institut Municipal d Investigació Mèdica Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Carrer del Dr Aiguader, 88, 08003, Barcelona, Spain
    Eur J Nucl Med Mol Imaging 36:1156-66. 2009
    The aim was to evaluate FDG PET imaging in Ela1-myc mice, a pancreatic cancer model resulting in the development of tumours with either acinar or mixed acinar-ductal phenotype.
  22. doi Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB
    Kumi O Kuroda
    Kuroda Research Unit for Affiliative Social Behavior, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Brain Res 1211:57-71. 2008
    ..We found up-regulation of glial fibrillary acidic protein (GFAP), C4, and Ela1 mRNA in the MPOA of FosB (-/-) mice; all of these gene products were implicated in general neuropathological ..
  23. pmc Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development
    Anthony D Bird
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
    J Physiol 585:187-201. 2007
    ..5 p.c. GR-null lungs included Chi3l3 (11-fold, P < 0.05), a macrophage inflammatory response gene and Ela1 (9.4-fold, P < 0.05), an extracellular matrix remodeling enzyme...
  24. pmc ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells
    Balazs Ribar
    University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555 1061, USA
    Mol Cell Biol 27:3211-6. 2007
    ..Here we show that elongin A (Ela1) and cullin 3 (Cul3) are required for Pol II polyubiquitylation and degradation in yeast cells, and on the basis of ..
  25. ncbi Radioimmunoassay of human pancreatic elastase 1. In vitro interaction of human pancreatic elastase 1 with serum protease inhibitors
    A Murata
    Enzyme 30:29-37. 1983
    A radioimmunoassay for determination of human pancreatic elastase 1 was developed and the interaction of pancreatic elastase 1 with serum protease inhibitors (alpha 2-macroglobulin and alpha 1-antitrypsin) was investigated...
  26. pmc Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans
    Edit Szepessy
    Department of Molecular and Cell Biology, Goldman School of Dental Medicine, Boston University, Boston, Mass, USA
    Pancreatology 6:117-22. 2006
    The archetypal mammalian elastase (ELA1) is not expressed in the human pancreas, because evolutionary mutations suppressed transcription of the ELA1 gene.
  27. ncbi Interaction between human pancreatic elastase and plasma protease inhibitors
    E L Gustavsson
    Hoppe Seylers Z Physiol Chem 361:169-76. 1980
    ..The elastase bound by alpha 2-macroglobulin retains its activity against low molecular weight substrates, while that bound by alpha 1-antitrypsin is enzymologically inactive...
  28. ncbi The role of PTF1-P48 in pancreatic acinar gene expression
    S D Rose
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 276:44018-26. 2001
    The 100-base pair ELA1 transcriptional enhancer drives high level transcription to pancreatic acinar cells of transgenic mice and in transfected pancreatic acinar cells in culture...
  29. ncbi Characterization of a silent gene for human pancreatic elastase I: structure of the 5'-flanking region
    T Tani
    J Biochem 101:591-9. 1987
    ..The transcriptional activity of the human elastase I gene appears to be suppressed in the human adult pancreas...
  30. ncbi DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex
    Y Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 276:17985-93. 2001
    ..The activity of the pancreas-specific ELA1 enhancer requires the cooperation of the trimer-binding element and a nearby element that binds the pancreatic ..
  31. ncbi Physical mapping of the human ELA1 gene between D12S361 and D12S347 on chromosome 12q13
    R L Davies
    Department of Biology, Sweet Briar College, Virginia 24595, USA
    Genomics 29:766-8. 1995
    ELA1, the pancreatic elastase 1 gene, is conserved in mammalian genomes. ELA1 was previously mapped to chromosome 12 using a panel of mouse-human somatic cell hybrids...
  32. ncbi Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism
    U Talas
    Center for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Whitechapel, London, UK
    J Invest Dermatol 114:165-70. 2000
    Human pancreatic elastase 1 is a serine protease which maps to the chromosomal region 12q13 close to a locus for an autosomal dominant skin disease, diffuse nonepidermolytic palmoplantar keratoderma, and was investigated as a possible ..
  33. pmc Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination
    D A Thompson
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403 1229, USA
    Genetics 153:621-41. 1999
    ..in diploid SPO13 meiosis in our strain background, and they identify alleles of UBR1, INP52, BUD3, PET122, ELA1, and MSC1-MSC3...
  34. pmc Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C
    M V Botuyan
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 96:9033-8. 1999
    ..ultracentrifugal sedimentation experiments to examine complexes of yeast elongin C (Elc1) with yeast elongin A (Ela1) and two peptides from homologous regions of Ela1 and human VHL...
  35. ncbi Analysis of transcriptional regulatory regions in vivo
    R J MacDonald
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235 9140, USA
    Int J Dev Biol 42:983-94. 1998
    ..A summary of the in vivo regulatory properties of the pancreas-specific transcriptional enhancer of the rat elastase 1 gene (ELA1) and the role individual elements in this enhancer play in directing high level, cell-specific ..
  36. pmc An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2)
    G H Swift
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Mol Cell Biol 18:5109-20. 1998
    ..PDX1 are exhibited through the 10-bp B element of the transcriptional enhancer of the pancreatic elastase I gene (ELA1)...
  37. ncbi Genomic organization of the human homologue of the rat pancreatic elastase I gene
    I Kawashima
    Bioscience Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    DNA Seq 2:303-12. 1992
    ....
  38. ncbi Evolutionary silencing of the human elastase I gene (ELA1)
    S D Rose
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235 9140, USA
    Hum Mol Genet 6:897-903. 1997
    ..Replacing the active 71 bp rat promoter with the human promoter also prevents expression. Therefore, the evolutionary silencing of the human elastase I gene appears due to mutations that inactivate crucial enhancer and promoter elements...
  39. ncbi Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments
    C Edelstein
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 272:11079-87. 1997
    ..Elastase-mediated proteolytic events may occur in vivo under conditions associated with either an excessive leakage of elastase from PMN and/or deficiencies of natural inhibitors of this enzyme...
  40. ncbi Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a]
    C Edelstein
    Department of Medicine, University of Chicago, IL 60637, USA
    J Lipid Res 37:1786-801. 1996
    ..The comparable size of apo[a] fragments observed in the urine of humans and injected mice invites the speculation that enzymes of the elastase family may play a role in the biology of Lp[a] in vivo...
  41. ncbi The in vitro interactions of rat pancreatic elastase and normal and inflammatory ray serum
    F Gauthier
    Biochim Biophys Acta 526:218-26. 1978
    ..The 60% value of alpha 1-M bound radioactivity in normal serum corresponds to the sum of alpha 1-M and alpha 2-AP labelling in inflammatory serum...
  42. pmc A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut
    S D Rose
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    Mol Cell Biol 14:2048-57. 1994
    ..Our results show that while the A element is responsible for directing tissue and cell type specificity, other elements of the enhancer must be involved in the regulation of the level of gene expression...
  43. ncbi Interactions in vitro and in vivo between human and porcine cationic pancreatic elastase and plasma protease inhibitors
    H O Håkansson
    Department of Surgery, University of Lund, Malmo General Hospital, Sweden
    Biol Chem Hoppe Seyler 369:309-15. 1988
    ..Porcine alpha 1-protease-inhibitor-bound elastase disappeared considerably more slowly...
  44. ncbi Elastin: relation of protein and gene structure to disease
    J Rosenbloom
    Lab Invest 51:605-23. 1984
    ..Elastin can be solubilized only by proteases that have consequently been designated elastases, although these are general, powerful proteases that can hydrolyze numerous proteins.(ABSTRACT TRUNCATED AT 400 WORDS)..
  45. ncbi Immunocytochemical localization of elastase 1 in human pancreas
    H Zhou
    Pathologisches Institut, Universitat Bonn, Germany
    Histochem Cell Biol 103:103-9. 1995
    By light and electron microscopic immunocytochemistry the distribution is described of human pancreatic elastase 1 (E1) during ontogenesis, in adults, in cases of acute and chronic pancreatitis, acute pancreatic ischaemia as well as ..
  46. ncbi Parathormone levels and Vitamin D metabolism in female patients with various grades of fecal elastase 1 deficiency
    J Teichmann
    Department of Internal Medicine, Medical Clinc C, Ludwigshafen, Germany
    Eur J Med Res 13:563-7. 2008
    ..still too few conclusive reports about conspicuous parathormone (PTH) and Vitamin D metabolism in patients with fecal elastase 1 deficiency or any connection of the calcium metabolism to the severity of exocrine pancreas insufficiency.
  47. doi Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus
    Jan Uwe Hahn
    Clinic for Diabetes and Metabolic Diseases, Klinikum Karlsburg, Karlsburg, Germany
    Pancreas 36:274-8. 2008
    On the basis of very low fecal elastase 1 and very high fecal fat estimations, it has been claimed that exocrine pancreatic insufficiency is frequent in diabetic patients, and that in up to 40% of the patients, pancreatic enzyme ..
  48. ncbi Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3
    Mette Vesterhus
    Department of Pediatrics, Haukeland University Hospital, Bergen, Norway
    Diabetes Care 31:306-10. 2008
    ..We wanted to investigate the prevalence of pancreatic exocrine dysfunction in patients with maturity-onset diabetes of the young type 3 (MODY3)...
  49. ncbi Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial
    Nils Ewald
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Diabetes Metab Res Rev 23:386-91. 2007
    Recently, high prevalence of exocrine dysfunction in diabetic populations has been reported. Patients with fecal elastase 1 concentration (FEC) <100 microg/g have also been demonstrated to suffer from steatorrhea in about 60% of cases, ..
  50. ncbi Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB
    Antti Hietaranta
    Department of General and Gastroenterological Surgery, Helsinki University Central Hospital, Haartmaninkatu 4, 00029 HUS, Helsinki, Finland
    Biochem Biophys Res Commun 323:192-6. 2004
    ..Our results suggest that pancreatic elastase-induced proinflammatory effects are mediated by TLR4 and NF-kappaB in human myeloid cells...
  51. ncbi Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual beta-cell secretion and metabolic control in type 1 diabetic subjects
    Franco Cavalot
    University of Turin, San Luigi Gonzaga Hospital, Department of Clinical and Biological Sciences, Diabetes Unit, 10043 Orbassano TO, Turin, Italy
    Diabetes Care 27:2052-4. 2004
  52. ncbi X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate
    R C Wilmouth
    The Dyson Perrins Laboratory and Oxford Centre for Molecular Sciences, University of Oxford, South Parks Road, Oxford OX1 3QY, UK
    Nat Struct Biol 8:689-94. 2001
    ..This affects the location of the peptide in the active site cleft, triggering the collapse of a hydrogen bonding network between the peptide and the beta-sheet of the active site...
  53. ncbi Evaluation of fecal pancreatic elastase-1 as a measure of pancreatic exocrine function in children with cystic fibrosis
    A Cade
    Regional Paediatric Cystic Fibrosis Unit, St James s University Hospital, Leeds, UK
    Pediatr Pulmonol 29:172-6. 2000
    ..The low values in the first 2 weeks in some normal and premature infants, and the persisting normal values in PS infants, make the fecal EL-1 test unsuitable for neonatal CF screening...
  54. ncbi Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase
    R C Wilmouth
    Oxford Centre for Molecular Sciences, UK
    Nat Struct Biol 4:456-62. 1997
    ..Deprotonation of Wat 317 will produce a hydroxide ion positioned to attack the ester carbonyl through the favoured Bürgi-Dunitz trajectory...
  55. ncbi Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis
    R Sepper
    Department of Anatomy, University of Helsinki, Finland
    J Clin Immunol 15:27-34. 1995
    ..The results indicate that insufficient endogenous downregulation of catalytically active elastase and cathepsin G in BALF leads to tissue injury, resulting in alterative and deformative processes in the bronchiectasis lung...

Research Grants1

  1. Miklos Sahin-Toth; Fiscal Year: 2016
    ..In humans, there are five pancreatic elastase genes (ELA1, ELA2A, ELA2B, ELA3A, and ELA3B) which give rise to three functional elastases (ELA2A, ELA3A and ELA3B)...