CELA2A

Summary

Gene Symbol: CELA2A
Description: chymotrypsin like elastase family member 2A
Alias: ELA2A, PE-1, chymotrypsin-like elastase family member 2A, elastase 2A, pancreatic elastase 2, pancreatic elastase IIA
Species: human
Products:     CELA2A

Top Publications

  1. Lausen J, Liu S, Fliegauf M, Lubbert M, Werner M. ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO. Oncogene. 2006;25:1349-57 pubmed
    ..These protein-protein interactions may not require simultaneous DNA binding by AML1-ETO for the deleterious effects of the fusion protein to be realized. ..
  2. Friess H, Ding J, Kleeff J, Liao Q, Berberat P, Hammer J, et al. Identification of disease-specific genes in chronic pancreatitis using DNA array technology. Ann Surg. 2001;234:769-78; discussion 778-9 pubmed
    ..These results may provide new insight into the pathobiology of CP and help identify certain molecular alterations that might serve as targets for new diagnostic tools and disease-specific therapy. ..
  3. Szepessy E, Sahin Toth M. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. Pancreatology. 2006;6:117-22 pubmed
    ..Recombinant ELA2A and ELA2B were expressed in Escherichia coli, and their activity was tested on Glt-Ala-Ala-Pro-Leu-p-nitroanilide, ..
  4. Kerns S, Ostrer H, Stock R, Li W, Moore J, Pearlman A, et al. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2010;78:1292-300 pubmed publisher
    ..This study demonstrates the feasibility of a genome-wide approach to investigate genetic predisposition to radiation injury. ..
  5. Szabo A, Pilsak C, Bence M, Witt H, Sahin Toth M. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. J Biol Chem. 2016;291:17706-16 pubmed publisher
    ..protease zymogens in a systematic manner, we performed binding experiments using recombinant proelastases CELA2A, CELA3A, and CELA3B; chymotrypsinogens CTRB1, CTRB2, CTRC, and CTRL1; and procarboxypeptidases CPA1, CPA2, and ..
  6. Damodaren N, Van Eeuwen T, Zamel J, Lin Shiao E, Kalisman N, Murakami K. Def1 interacts with TFIIH and modulates RNA polymerase II transcription. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
    ..Taken together, our results extend the understanding of the molecular mechanism of transcription regulation on cellular stress and reveal functional similarities to the mammalian system...
  7. Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, et al. Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. J Biochem. 1987;102:1555-63 pubmed
    We have cloned a DNA that is complementary to the messenger RNA that encodes human pancreatic elastase 2 from a human pancreatic cDNA library using a cloned cDNA for rat pancreatic elastase 2 messenger RNA...
  8. Fletcher T, Shen W, Largman C. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. Biochemistry. 1987;26:7256-61 pubmed
    ..These studies indicate that elastases 2 and elastase 1 both contain an Arg-65A as well as a basic dipeptide at 223/224 which is not present in chymotrypsins.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  9. Kawashima I, Tani T, Shimoda K, Takiguchi Y. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. DNA. 1987;6:163-72 pubmed
    ..Blot hybridization analysis of the poly-adenylated RNAs isolated from various human tissues demonstrates that the human elastase II mRNAs are specifically detected in the pancreas. ..
  10. Moulard M, Michon T, Kerfelec B, Chapus C. Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. FEBS Lett. 1990;261:179-83 pubmed
    ..Only one type of procarboxypeptidase B, the B1 type, has been detected in the analyzed pancreatic juices, thus emphasizing the previously observed genetic differences between individuals. ..

Scientific Experts

Detail Information

Publications12

  1. Lausen J, Liu S, Fliegauf M, Lubbert M, Werner M. ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO. Oncogene. 2006;25:1349-57 pubmed
    ..These protein-protein interactions may not require simultaneous DNA binding by AML1-ETO for the deleterious effects of the fusion protein to be realized. ..
  2. Friess H, Ding J, Kleeff J, Liao Q, Berberat P, Hammer J, et al. Identification of disease-specific genes in chronic pancreatitis using DNA array technology. Ann Surg. 2001;234:769-78; discussion 778-9 pubmed
    ..These results may provide new insight into the pathobiology of CP and help identify certain molecular alterations that might serve as targets for new diagnostic tools and disease-specific therapy. ..
  3. Szepessy E, Sahin Toth M. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. Pancreatology. 2006;6:117-22 pubmed
    ..Recombinant ELA2A and ELA2B were expressed in Escherichia coli, and their activity was tested on Glt-Ala-Ala-Pro-Leu-p-nitroanilide, ..
  4. Kerns S, Ostrer H, Stock R, Li W, Moore J, Pearlman A, et al. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2010;78:1292-300 pubmed publisher
    ..This study demonstrates the feasibility of a genome-wide approach to investigate genetic predisposition to radiation injury. ..
  5. Szabo A, Pilsak C, Bence M, Witt H, Sahin Toth M. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. J Biol Chem. 2016;291:17706-16 pubmed publisher
    ..protease zymogens in a systematic manner, we performed binding experiments using recombinant proelastases CELA2A, CELA3A, and CELA3B; chymotrypsinogens CTRB1, CTRB2, CTRC, and CTRL1; and procarboxypeptidases CPA1, CPA2, and ..
  6. Damodaren N, Van Eeuwen T, Zamel J, Lin Shiao E, Kalisman N, Murakami K. Def1 interacts with TFIIH and modulates RNA polymerase II transcription. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
    ..Taken together, our results extend the understanding of the molecular mechanism of transcription regulation on cellular stress and reveal functional similarities to the mammalian system...
  7. Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, et al. Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. J Biochem. 1987;102:1555-63 pubmed
    We have cloned a DNA that is complementary to the messenger RNA that encodes human pancreatic elastase 2 from a human pancreatic cDNA library using a cloned cDNA for rat pancreatic elastase 2 messenger RNA...
  8. Fletcher T, Shen W, Largman C. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. Biochemistry. 1987;26:7256-61 pubmed
    ..These studies indicate that elastases 2 and elastase 1 both contain an Arg-65A as well as a basic dipeptide at 223/224 which is not present in chymotrypsins.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  9. Kawashima I, Tani T, Shimoda K, Takiguchi Y. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. DNA. 1987;6:163-72 pubmed
    ..Blot hybridization analysis of the poly-adenylated RNAs isolated from various human tissues demonstrates that the human elastase II mRNAs are specifically detected in the pancreas. ..
  10. Moulard M, Michon T, Kerfelec B, Chapus C. Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. FEBS Lett. 1990;261:179-83 pubmed
    ..Only one type of procarboxypeptidase B, the B1 type, has been detected in the analyzed pancreatic juices, thus emphasizing the previously observed genetic differences between individuals. ..
  11. Dooley J, Pasciuto E, Lagou V, Lampi Y, Dresselaers T, Himmelreich U, et al. NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer. Oncotarget. 2017;8:80167-80174 pubmed publisher
    ....
  12. Bonnart C, Deraison C, Lacroix M, Uchida Y, Besson C, Robin A, et al. Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest. 2010;120:871-82 pubmed publisher
    ..These results highlight the importance of the control of epidermal protease activity in skin homeostasis and designate ELA2 as a major protease driving the pathogenesis of NS. ..