CETP

Summary

Gene Symbol: CETP
Description: cholesteryl ester transfer protein
Alias: BPIFF, HDLCQ10, cholesteryl ester transfer protein, BPI fold containing family F, cholesteryl ester transfer protein plasma, lipid transfer protein I
Species: human

Top Publications

  1. doi Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study
    Maria C Izar
    Cardiology Division, Department of Medicine, Rua Pedro de Toledo 276, Sao Paulo, SP, Brazil
    Atherosclerosis 204:165-70. 2009
  2. pmc Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 12:123. 2011
  3. ncbi The -629C>A polymorphism in the CETP gene does not explain the association of TaqIB polymorphism with risk and age of myocardial infarction in Icelandic men
    G Eiriksdottir
    Molecular Genetics Laboratory, Hjartavernd, Icelandic Heart Association, Lagmuli 9, 108, Reykjavik, Iceland
    Atherosclerosis 159:187-92. 2001
  4. ncbi Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes
    Francine V van Venrooij
    Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 26:1216-23. 2003
  5. ncbi A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Biological Sciences, University of Durham, Durham, UK
    Eur Heart J 24:1833-42. 2003
  6. ncbi TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia
    Martina F Mohrschladt
    Department of General Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Hum Genet 13:877-82. 2005
  7. pmc The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease
    Genovefa Kolovou
    1st Cardiology Department, Onassis Cardiac Surgery Center 356, Sygrou Ave, 176 74 Athens, Greece
    Lipids Health Dis 10:156. 2011
  8. ncbi Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver
    Andre Gauthier
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada
    Arterioscler Thromb Vasc Biol 25:2177-84. 2005
  9. ncbi High-density genotyping and functional SNP localization in the CETP gene
    John F Thompson
    Pharmacogenomics, Pfizer Global Research and Development, Groton, CT 06340, USA
    J Lipid Res 48:434-43. 2007
  10. doi Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008

Research Grants

  1. Yuqing Eugene Chen; Fiscal Year: 2016
  2. Gang Ren; Fiscal Year: 2016
  3. Carboxyl Ester Lipase Affects Hepatic HDL Metabolism
    PHILIP HOWLES; Fiscal Year: 2009
  4. Gang Ren; Fiscal Year: 2016
  5. Genetics of Elevated High Density Lipoprotein Cholesterol
    DANIEL JAMES RADER; Fiscal Year: 2012
  6. Role of Genes in Exceptional Longevity in Humans
    NIR J BARZILAI; Fiscal Year: 2012
  7. RICHARD LOUIS KLEIN; Fiscal Year: 2015
  8. Mary G Sorci-Thomas; Fiscal Year: 2015
  9. DANIEL JAMES RADER; Fiscal Year: 2016
  10. HDL Structure and Metabolism During Inflammation
    Frederick C de Beer; Fiscal Year: 2011

Detail Information

Publications263 found, 100 shown here

  1. doi Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study
    Maria C Izar
    Cardiology Division, Department of Medicine, Rua Pedro de Toledo 276, Sao Paulo, SP, Brazil
    Atherosclerosis 204:165-70. 2009
    ..APO A1 (A/G -75 and C/T +83) and APO C3 (C/G 3'UTR) non-coding sequences, CETP (Taq 1B), LPL (D9N), APO E (epsilon2, epsilon3, epsilon4,), PON-1 (Q192R), and two LCAT variants Arg(147)-->Trp ..
  2. pmc Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 12:123. 2011
    ....
  3. ncbi The -629C>A polymorphism in the CETP gene does not explain the association of TaqIB polymorphism with risk and age of myocardial infarction in Icelandic men
    G Eiriksdottir
    Molecular Genetics Laboratory, Hjartavernd, Icelandic Heart Association, Lagmuli 9, 108, Reykjavik, Iceland
    Atherosclerosis 159:187-92. 2001
    ..effect of the common TaqIB polymorphism in intron 1 of the gene for cholesterol ester transfer protein (CETP) on high density lipoprotein cholesterol (HDL-C) concentration and increased risk of myocardial infarction (MI), ..
  4. ncbi Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes
    Francine V van Venrooij
    Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 26:1216-23. 2003
    The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles. Sequence variations in the CETP gene may interfere with the effect of lipid-lowering treatment in type 2 diabetes...
  5. ncbi A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Biological Sciences, University of Durham, Durham, UK
    Eur Heart J 24:1833-42. 2003
    The association of cholesteryl ester transfer protein (CETP) gene polymorphisms with risk of a cardiovascular event and whether any association was explained by an influence on high-density lipoprotein (HDL) levels or low-density ..
  6. ncbi TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia
    Martina F Mohrschladt
    Department of General Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Hum Genet 13:877-82. 2005
    The effects of TaqI restriction fragment length polymorphism of the CETP gene on the occurrence of cardiovascular disease (CVD) events were investigated in patients with familial hypercholesterolemia (FH)...
  7. pmc The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease
    Genovefa Kolovou
    1st Cardiology Department, Onassis Cardiac Surgery Center 356, Sygrou Ave, 176 74 Athens, Greece
    Lipids Health Dis 10:156. 2011
    The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis.
  8. ncbi Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver
    Andre Gauthier
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada
    Arterioscler Thromb Vasc Biol 25:2177-84. 2005
    To determine whether cholesteryl ester transfer protein (CETP) directly mediates selective uptake of high-density lipoprotein (HDL)-cholesteryl ester (CE) by hepatocytes and to quantify the effects of the CETP inhibitor, torcetrapib, on ..
  9. ncbi High-density genotyping and functional SNP localization in the CETP gene
    John F Thompson
    Pharmacogenomics, Pfizer Global Research and Development, Groton, CT 06340, USA
    J Lipid Res 48:434-43. 2007
    The cholesteryl ester transfer protein gene (CETP) has been the subject of hundreds of genetic analyses that typically focus on a small number of polymorphisms within a single ethnic group...
  10. doi Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
    ..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
  11. pmc Cholesteryl ester transfer protein gene polymorphisms and longevity syndrome
    Genovefa Kolovou
    1st Cardiology Department, Onassis Cardiac Surgery Center Athens, Greece
    Open Cardiovasc Med J 4:14-9. 2010
    ..Since HDL particles are influenced by cholesteryl ester transfer protein (CETP) activity, it is worth studying the CETP polymorphism...
  12. ncbi Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study
    Eric Frisdal
    Institut National de la Sante et de la Recherche Medicale, INSERM Unité 551, Dyslipoproteinemia and Atherosclerosis, Paris Cedex, France
    Hum Mol Genet 14:2607-18. 2005
    b>Cholesteryl ester transfer protein (CETP) plays a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism...
  13. ncbi Unique lipoprotein phenotype and genotype associated with exceptional longevity
    Nir Barzilai
    Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
    JAMA 290:2030-40. 2003
    ..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
  14. pmc Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
    Atherosclerosis 200:359-67. 2008
    The cholesteryl ester transfer protein (CETP) plays a key role in high-density lipoprotein (HDL) metabolism...
  15. ncbi Lack of association of the common TaqIB polymorphism in the cholesteryl ester transfer protein gene with angiographically assessed coronary atherosclerosis
    M Arca
    Istituto di Terapia Medica Sistematica, Universita degli Studi di Roma La Sapienza, Italy
    Clin Genet 60:374-80. 2001
    The anti-atherogenic effect of cholesteryl ester transfer protein (CETP) genetic variants associated with lowered enzyme activity is controversial...
  16. ncbi Cholesteryl ester-transfer protein (CETP) polymorphism and the association of acute coronary syndromes by obesity status in Greek subjects: the CARDIO2000-GENE study
    George V Dedoussis
    Department of Dietetics Nutrition, Harokopio University, Athens, Greece
    Hum Hered 63:155-61. 2007
    Cholesterol ester transfer protein (CETP) regulates plasma lipid distribution. The present study aimed to investigate whether the CETP gene (Taq1B) polymorphism predisposes to Acute Coronary Syndromes (ACS) depending on obesity status.
  17. pmc Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction
    V Meiner
    Department of Human Genetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Ann Hum Genet 72:732-41. 2008
    Although Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl esters and triglycerides between lipoprotein particles and thus plays a crucial role in reverse cholesterol transport, the association of variations ..
  18. doi Lack of association between the cholesteryl ester transfer protein gene--TaqIB polymorphism and coronary restenosis following percutaneous transluminal coronary angioplasty and stenting: a pilot study
    Sabine Kaestner
    Department of Pharmacology, Patras University School of Medicine, Rio, Patras, Greece
    Angiology 61:338-43. 2010
    The most widely studied variation at the cholesteryl ester transfer protein (CETP) gene locus is a silent base change called the Thermobius aquaticus IB (TaqIB) polymorphism...
  19. ncbi The association of cholesteryl ester transfer protein polymorphism with high-density lipoprotein cholesterol and coronary artery disease in Koreans
    K W Park
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Clin Genet 63:31-8. 2003
    b>Cholesteryl ester transfer protein (CETP) is a key protein involved in high-density lipoprotein cholesterol (HDL-C) metabolism...
  20. ncbi Association between cholesteryl ester transfer protein gene polymorphisms and variations in lipid levels in patients with coronary heart disease
    Ke Qin Zheng
    Department of Medical Genetics, West China Hospital, Chengdu 610041, China
    Chin Med J (Engl) 117:1288-92. 2004
    The Taq/B, Msp/ and I405V polymorphisms of cholesteryl ester transfer protein (CETP), an important regulatory factor of lipid metabolism, have been attracted much more attention by the researchers...
  21. ncbi Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease
    Pamela A McCaskie
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Nedlands, WA, 6009, Australia
    Hum Genet 121:401-11. 2007
    ..b>Cholesteryl ester transfer protein (CETP) is a key protein in HDL-C metabolism such that elevated CETP activity is associated with ..
  22. ncbi Multiple less common genetic variants explain the association of the cholesteryl ester transfer protein gene with coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, University of Utah, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 49:2053-60. 2007
    The objective of this study was to identify associations of the cholesteryl ester transfer protein (CETP) gene with coronary artery disease (CAD) with tagging (t) single nucleotide polymorphisms (SNPs) chosen to optimally account for ..
  23. doi Association of the cholesteryl ester transfer protein Taq1 B2B2 genotype with higher high-density lipoprotein cholesterol concentrations and lower risk of coronary artery disease in a Tunisian population
    Jihene Rejeb
    Biochemistry Department, UR MSP28 04, Sahloul University Hospital, 4054 Sousse, Tunisia
    Arch Cardiovasc Dis 101:629-36. 2008
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is undergoing debate.
  24. doi Cholesteryl ester transfer protein TaqIB, -629C>A and I405V polymorphisms and risk of coronary heart disease in an Indian population
    N Padmaja
    Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India
    Clin Chim Acta 402:139-45. 2009
    ..Polymorphisms in cholesteryl ester protein gene have been linked to risk of coronary heart disease (CHD) in many world populations through their effect on reverse cholesterol transport...
  25. doi Association between cholesteryl ester transfer protein TaqIB variants and risk of coronary artery disease and diabetes mellitus in the population of western Iran
    Zohreh Rahimi
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
    Genet Test Mol Biomarkers 15:813-9. 2011
    To shed light on the previously inconsistent results about the association of cholesteryl ester transfer protein TaqIB (CETP TaqIB) variants, high-density lipoprotein cholesterol (HDL-C) levels, and the risk of coronary artery disease (..
  26. ncbi Variation at the cholesteryl ester transfer protein gene in relation to plasma high density lipoproteins cholesterol levels and carotid intima-media thickness
    S Kakko
    University of Oulu, Oulu, Finland, National Public Health Institute, Helsinki, Finland
    Eur J Clin Invest 31:593-602. 2001
    b>Cholesteryl ester transfer protein (CETP) plays a major role in lipoprotein metabolism...
  27. ncbi The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease
    Alejandro Arias-Vasquez
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurogenetics 8:189-93. 2007
    ..apolipoprotein E (APOE) gene, the most common genetic determinant for Alzheimer's disease (AD), the cholesteryl ester transfer protein (CETP) is involved in lipid metabolism...
  28. doi A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a Caucasian kindred
    Laura Calabresi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Italy
    Atherosclerosis 205:506-11. 2009
    To analyze the cholesteryl ester transfer protein (CETP) gene and the plasma HDL phenotype in a Caucasian subject with extremely elevated plasma high density lipoprotein-cholesterol (HDL-C).
  29. ncbi Influence of CETP gene variation on plasma lipid levels and coronary heart disease: a survey in Taiwan
    J H Wu
    Department of Microbiology and Immunology, College of Medicine, Chang Gung University, 259 Wen Hua I Road, Tao Yuan 333, Kwei San, Taiwan
    Atherosclerosis 159:451-8. 2001
    b>Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester from high-density lipoprotein (HDL) to very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and chylomicron in exchange for triglycerides...
  30. ncbi CETP polymorphisms associated with HDL cholesterol may differ from those associated with cardiovascular disease
    John F Thompson
    Discovery Pharmacogenomics, Pfizer Global Research and Development, Groton, CT 06340, USA
    Atherosclerosis 181:45-53. 2005
    To better understand the role of cholesteryl ester transfer protein (CETP) in cardiovascular disease, nine polymorphisms spanning the gene from the upstream promoter region to beyond the 3'UTR were genotyped in 2553 individuals from ..
  31. pmc Mechanism of inhibition defines CETP activity: a mathematical model for CETP in vitro
    Laura K Potter
    Scientific Computing and Mathematical Modeling, GlaxoSmithKline, King of Prussia, PA, USA
    J Lipid Res 50:2222-34. 2009
    Because cholesteryl ester transfer protein (CETP) inhibition is a potential HDL-raising therapy, interest has been raised in the mechanisms and consequences of CETP activity...
  32. doi Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk
    Alexander Thompson
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, England CB1 8RN
    JAMA 299:2777-88. 2008
    The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary disease is uncertain. Study of CETP genotypes can help better understand the relevance of this pathway to lipid metabolism and disease risk.
  33. pmc Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7088, USA
    Circ Cardiovasc Genet 3:31-8. 2010
    ....
  34. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
    ..In addition, our data revealed strong association signals with alleles at two loci (LIPC, P = 1.3 x 10(-7); CETP, P = 7...
  35. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
  36. ncbi Differential effect of ATP binding cassette transporter A1 R219K and cholesteryl ester transfer protein TaqIB genotypes on HDL-C levels in overweight/obese and non-obese Chinese subjects
    Yi Huang
    Laboratory of Genetic Disease and Perinatal Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P R China
    Acta Cardiol 66:231-7. 2011
    ATP-binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) are involved in the HDL metabolism and play a key role in reverse cholesterol transport...
  37. pmc Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol
    Ian Tietjen
    Xenon Pharmaceuticals Inc, Burnaby, Canada
    PLoS ONE 7:e37437. 2012
    ..Here we sequenced the coding regions and adjacent sequence of the LIPG, CETP, and GALNT2 genes in 171 unrelated Dutch Caucasian probands with HDLc≥90th percentile and analyzed segregation of ..
  38. ncbi Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins
    M L Brown
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Nature 342:448-51. 1989
    ..The plasma cholesteryl ester transfer protein (CETP) catalyses the transfer of cholesteryl ester from HDL to other lipoproteins and therefore ..
  39. ncbi Cholesteryl ester transfer protein TaqIB polymorphism and its relation to parameters of the insulin resistance syndrome in an Austrian cohort
    R Weitgasser
    1st Department of Medicine, St Johanns Spital, Paracelsus Medical University Salzburg, Salzburg, Austria
    Biomed Pharmacother 58:619-27. 2004
    The cholesteryl ester transfer protein (CETP) is responsible for the exchange of triglycerides and cholesteryl esters between lipoprotein particles leading to an increased hepatic clearance of HDL-cholesteryl esters...
  40. doi Association of cholesteryl ester transfer protein (TaqIB) and apolipoprotein E (HhaI) gene variants with obesity
    Neena Srivastava
    Department of Physiology, Chatrapati Shahuji Maharaj Medical University, Lucknow, India
    Mol Cell Biochem 314:171-7. 2008
    ..We aimed to evaluate association of cholesteryl ester transfer protein (CETP) and apolipoprotein (APO) E gene variants with asymptomatic obesity...
  41. pmc Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study
    Andreas Ritsch
    Department of Internal Medicine I, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Circulation 121:366-74. 2010
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still open to debate...
  42. ncbi Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants
    Kathy L E Klos
    University of Texas Health Science Center at Houston, School of Public Health, Human Genetics Center, P O Box 20186, Houston, Texas 77225, USA
    Arterioscler Thromb Vasc Biol 26:1828-36. 2006
    ..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
  43. ncbi Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease
    S Matthijs Boekholdt
    Academic Medical Center, Department of Cardiology, Room F3 241, 1100 DD Amsterdam, The Netherlands
    J Lipid Res 44:1080-93. 2003
    Since the identification of cholesteryl ester transfer protein (CETP), its role in the modulation of HDL levels and cardiovascular disease has been debated...
  44. ncbi [Role of cholesteryl ester transfer protein activity and genetic polymorphism in ischemic heart disease in type 2 diabetic patients]
    Raja Chaaba
    Laboratoire de Biochimie, Unité de Recherche UR08 de Monastir
    Tunis Med 82:282-8. 2004
    b>Cholesteryl Ester Transfer Protein (CETP) facilates the exchange of triglycerides (TG) and cholesteryl ester between lipoproteins particles...
  45. doi Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Clin Chem 55:481-8. 2009
    ATP-binding cassette A1 (ABCA1) and cholesteryl ester transfer protein (CETP) play important roles in the reverse cholesterol transport pathway...
  46. ncbi Taq1B polymorphism of cholesteryl ester transfer protein (CETP) gene in primary combined hyperlipidaemia
    Taghi Hassanzadeh
    Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
    Indian J Med Res 129:293-8. 2009
    b>Cholesteryl ester transfer protein (CETP) gene polymorphism is known to be associated with changes in lipid profiles...
  47. ncbi Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation
    A Inazu
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    N Engl J Med 323:1234-8. 1990
    The plasma cholesteryl-ester transfer protein (CETP) catalyzes the transfer of cholesteryl esters from high-density lipoprotein (HDL) to other lipoproteins...
  48. pmc A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins
    K Takahashi
    Second Department of Internal Medicine, Chiba University, Japan
    J Clin Invest 92:2060-4. 1993
    Plasma HDL are a negative risk factor for atherosclerosis. Cholesteryl ester transfer protein (CETP; 476 amino acids) transfers cholesteryl ester from HDL to other lipoproteins...
  49. ncbi Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and plasma lipoprotein levels in familial hypercholesterolemia
    R Carmena-Ramon
    Department of Medicine, Hospital Clinico Universitario, University of Valencia, Valencia, Spain
    Metabolism 50:651-6. 2001
    b>Cholesteryl ester transfer protein (CETP) facilitates the exchange of triglycerides (TG) and cholesteryl ester between lipoprotein particles...
  50. ncbi Genetic variations in the cholesteryl ester transfer protein gene and high density lipoprotein cholesterol levels in Taiwanese Chinese
    Lung An Hsu
    The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, No 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China
    Hum Genet 110:57-63. 2002
    ..analyzed the association of the I14A mutation, the D442G mutation, and the TaqIB polymorphism of the cholesteryl ester transfer protein (CETP) gene in 718 Chinese individuals with high-density lipoprotein cholesterol levels (HDL-C) ..
  51. ncbi The frequency of the cholesteryl ester transfer protein-TaqI B2 allele is lower in African Americans than in Caucasians
    Marina Cuchel
    Department of Medicine, University of Pennsylvania, School of Medicine, 654 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Atherosclerosis 163:169-74. 2002
    b>Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl ester for triglyceride between high density lipoprotein (HDL) and very low density lipoprotein...
  52. ncbi Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration
    Anke H E M Klerkx
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Hum Mol Genet 12:111-23. 2003
    The TaqIB polymorphism in intron 1 of the cholesteryl ester transfer protein (CETP) gene is associated with plasma CETP concentration, high-density lipoprotein cholesterol (HDL-C) and coronary artery disease (CAD)...
  53. ncbi The TaqIB and -629C>A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey
    E S Tai
    Department of Endocrinology, Singapore General Hospital, Singapore
    Clin Genet 63:19-30. 2003
    ..We studied the TaqIB and -629C>A polymorphisms at the CETP locus in 1300 Chinese, 364 Malay and 282 Asian Indian men, and in 1558 Chinese, 397 Malay and 306 Asian Indian ..
  54. ncbi Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis
    Philip J Barter
    Hanson Institute and the Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia
    Arterioscler Thromb Vasc Biol 23:160-7. 2003
    b>Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including VLDLs, VLDL remnants, IDLs, and LDLs...
  55. ncbi Association between the cholesteryl ester transfer protein TaqI-detectable B polymorphism and low high-density lipoprotein cholesterol concentration in Saudis
    Nassr M Al-Daghri
    Department of Clinical Biochemistry, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
    Clin Sci (Lond) 105:467-72. 2003
    ..A B polymorphism at the CETP (cholesteryl ester protein transfer) locus that is detectable with the restriction enzyme Taq I is a genetic ..
  56. ncbi Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery disease
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
    J Am Coll Cardiol 41:1983-9. 2003
    We sought to evaluate the association between cholesteryl ester transfer protein (CETP) genotypes and the risk of future cardiovascular mortality in patients with coronary artery disease (CAD).
  57. ncbi Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men
    Camilla Skoglund-Andersson
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Atherosclerosis 167:311-7. 2003
    ..Common variants in the cholesteryl ester transfer protein (CETP-629C/A), lipoprotein lipase (LPL S447X), hepatic lipase (HL-480C/T) and apolipoprotein E (apoE ..
  58. ncbi A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly
    J D Curb
    Pacific Health Research Institute, Honolulu, HI, USA
    J Lipid Res 45:948-53. 2004
    ..Genetic factors, including variations in the cholesteryl ester transfer protein (CETP) gene, play a role in determining HDL-C levels...
  59. ncbi The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome: a prospective analysis of the CETP TaqIB poly
    Greetje J de Grooth
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 43:854-7. 2004
    On the basis of quantitative coronary angiography data, the cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism has been postulated to predict the progression of coronary atherosclerosis and response to cholesterol-lowering ..
  60. ncbi An association study of the cholesteryl ester transfer protein TaqI B polymorphism with late onset Alzheimer's disease
    Liana Fidani
    Department of General Biology, School of Medicine, Aristotle University, Thessaloniki 54124, Greece
    Neurosci Lett 357:152-4. 2004
    b>Cholesteryl ester transfer protein (CETP) is reportedly able to affect the amount of cholesterol available for deposition and/or removal from peripheral tissues, in its capacity to mediate the transfer of cholesterol from high density ..
  61. ncbi Variations in high-density lipoprotein cholesterol in relation to physical activity and Taq 1B polymorphism of the cholesteryl ester transfer protein gene
    M Mukherjee
    Cardiac Research Laboratory, Cumballa Hill Hospital and Heart Institute, Mumbai, Maharashtra, India
    Clin Genet 65:412-8. 2004
    ..of the study was to determine any association of physical activity and Taq 1B polymorphism in the cholesteryl ester transfer protein gene on high-density lipoprotein (HDL) cholesterol...
  62. ncbi Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects
    S M Boekholdt
    Department of Cardiology, Academic Medical Center, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 111:278-87. 2005
    Several studies have reported that the cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism is associated with HDL cholesterol (HDL-C) levels and the risk of coronary artery disease (CAD), but the results are inconsistent...
  63. ncbi The effect of cholesteryl ester transfer protein -629C->A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides
    Susanna E Borggreve
    Department of Endocrinology, University Medical Centre Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 90:4198-204. 2005
    The -629C-->A cholesteryl ester transfer protein (CETP) promoter polymorphism is a determinant of HDL cholesterol (HDL-C)...
  64. ncbi Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease
    Haiyan Zhu
    Department of Physiology, University of Kentucky, 800 S Limestone St, Lexington, KY 40536 0230, USA
    Neurosci Lett 381:36-41. 2005
    ..Recently, several single nucleotide polymorphisms (SNPs) in cholesteryl ester transfer protein (CETP) were associated with altered plasma CETP concentrations, cholesterol concentrations and CAD...
  65. ncbi Pharmacogenetic study of apolipoprotein E, cholesteryl ester transfer protein and hepatic lipase genes and simvastatin therapy in Brazilian subjects
    Marilu Fiegenbaum
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Clin Chim Acta 362:182-8. 2005
    ..Polymorphisms in apolipoprotein E (APOE), cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC), proteins with major roles in lipid metabolism and homeostasis have ..
  66. ncbi Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  67. ncbi Carriers of three polymorphisms of cholesteryl ester transfer protein gene are at increased risk to coronary heart disease in a Chinese population
    Keqin Zheng
    Department of Medical Genetics, West China Hospital and Division of Human Morbid Genomics, Key Laboratory of Biotherapy of Human Diseases of Ministry of Education, Sichuan University, Chengdu 610041, China
    Int J Cardiol 103:259-65. 2005
    The cholesteryl ester transfer protein (CETP) is a key participant in the reverse transport of cholesterol from the peripheral tissue to the liver and the polymorphism in the CETP gene may therefore alter the susceptibility to coronary ..
  68. ncbi Prevalence of genetic risk factors for coronary artery disease in Corsica island (France)
    A Falchi
    Department of Human Genetics, Faculty of Science, University of Corsica, BP52 20250 Corte Corsica, France
    Exp Mol Pathol 79:210-3. 2005
    ..system: Angiotensin converting enzyme (ACE I/D), (2) Lipid metabolism: Cholesterol Ester Transfer Protein gene (CETP TAQ1B), (3) Platelet aggregation: alpha and beta subunits of the platelet GpIIb/GpIIIa integrin complex (GpIIb HPA3 ..
  69. ncbi Cholesteryl ester transfer protein gene polymorphisms and severity of coronary stenosis
    Genovefa D Kolovou
    Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece
    Clin Invest Med 29:14-9. 2006
    b>Cholesteryl ester transfer protein (CETP) gene is involved in the reverse cholesterol transport in humans. Thus, it is a candidate for studying the susceptibility to coronary heart disease (CHD)...
  70. ncbi An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: a population-based study
    Susanna E Borggreve
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 91:3382-8. 2006
    Several cholesteryl ester transfer protein (CETP) polymorphisms affect high-density lipoprotein (HDL) cholesterol, but the impact of CETP gene variants on incident coronary disease in the general population is uncertain after correction ..
  71. ncbi CETP (cholesteryl ester transfer protein) promoter -1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia
    Mutsuko Takata
    Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 111:325-31. 2006
    CETP (cholesteryl ester transfer protein) and HL (hepatic lipase) play a role in the metabolism of plasma lipoproteins, but the effects of CETP and LIPC (gene encoding HL) genotypes on coronary atherosclerosis may be dependent on LDL (low-..
  72. ncbi Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice
    Marit Westerterp
    Department of Biomedical Research, Gaubius Laboratory, CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2552-9. 2006
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate...
  73. ncbi Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus
    Ming Chia Hsieh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
    Metabolism 56:745-50. 2007
    ..b>Cholesteryl ester transfer protein (CETP) gene TaqIB polymorphism is associated with lipid profile variability, and this polymorphism ..
  74. ncbi CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study
    Nadine Spielmann
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 31:25-31. 2007
    Associations between cholesteryl ester transfer protein (CETP) polymorphisms and high-density lipoprotein cholesterol (HDL-c) levels before and after 20 wk of endurance training were investigated in the HERITAGE Family Study...
  75. ncbi Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
    Genovefa Kolovou
    1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece
    Clin Chem Lab Med 45:1190-8. 2007
    We examined the influence of cholesteryl ester transfer protein TaqIB polymorphism on triglyceride (TG) response to an oral fat tolerance test (OFTT) in patients heterozygous for familial hypercholesterolemia (hFH).
  76. pmc Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study
    Alanna M Chamberlain
    Division of Epidemiology and Community Health, University of Minnesota, School of Public Health, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, United States
    Atherosclerosis 200:322-8. 2008
    ..E (apoE Cys112Arg and Arg158Cys) gene and LDL-c levels, as well as the associations between the cholesteryl ester transfer protein (CETP TaqIB), hepatic lipase (LIPC C-514T), and lipoprotein lipase (LPL Ser447Stop) genes and HDL-c ..
  77. doi Expression of CETP and of splice variants induces the same level of ER stress despite secretion efficiency differences
    Maruja E Lira
    Molecular Medicine, Pfizer Global Research and Development, Groton, CT 06340, USA
    J Lipid Res 49:1955-62. 2008
    The cholesteryl ester transfer protein (CETP) gene has been associated with a variety of phenotypes, including HDL-cholesterol levels and, more sporadically, with cardiovascular disease, obesity, and extreme longevity...
  78. doi Cholesteryl ester transfer protein (CETP) increases postprandial triglyceridaemia and delays triacylglycerol plasma clearance in transgenic mice
    Alessandro G Salerno
    Departamento Fisiologia e Biofísica, Instituto de Biologia, UNICAMP Universidade Estadual de Campinas, Campinas, SP, Brazil
    Biochem J 419:629-34. 2009
    The CETP (cholesteryl ester transfer protein) is a plasma protein synthesized in several tissues, mainly in the liver; CETP reduces plasma HDL (high-density lipoprotein) cholesterol and increases the risk of atherosclerosis...
  79. ncbi Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population: the Suita study
    Yumiko Hiura
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita 565 8565, Japan
    Circ J 73:1119-26. 2009
    ....
  80. doi TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population
    Xiaoyang Ruan
    Beijing Hypertension League Institute, China
    Acta Diabetol 47:217-24. 2010
    ..Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association...
  81. doi Two novel mutations and functional analyses of the CETP and LIPC genes underlying severe hyperalphalipoproteinemia
    Wanee Plengpanich
    Biomedical Sciences Program, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand
    Metabolism 58:1178-84. 2009
    ..We investigated whether activities in cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) contribute to HALP in the Thai population and performed genetic ..
  82. doi Association of cholesteryl ester transfer protein -629C > A polymorphism with high-density lipoprotein cholesterol levels in coronary artery disease patients
    Sevda Tanrikulu
    Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University, Istanbul, Turkey
    Cell Biochem Funct 27:452-7. 2009
    ..The cholesteryl ester transfer protein (CETP) -629C > A polymorphism is associated with lower plasma CETP concentration, with increased ..
  83. pmc Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia
    Amy E Sanders
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    JAMA 303:150-8. 2010
    Polymorphisms in the cholesteryl ester transfer protein (CETP) gene have been associated with exceptional longevity and lower cardiovascular risk, but associations with memory decline and dementia risk are unclear.
  84. pmc Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
    ..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
  85. pmc Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study
    Mohammad Ali Kashani Farid
    Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, I R Iran
    Lipids Health Dis 9:96. 2010
    ..Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and ..
  86. pmc Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults
    Andrew J Clifford
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Lipids Health Dis 12:66. 2013
    ..We used a linear regression model. Selected genes corresponded to folate metabolism, vitamins B-12, A, and E, and cholesterol pathways or lipid metabolism...
  87. ncbi Common variants of Cholesteryl ester transfer protein gene and their association with lipid parameters in healthy volunteers of Tamilian population
    N Padmaja
    Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India
    Clin Chim Acta 375:140-6. 2007
    b>Cholesteryl ester transfer protein (CETP) is involved in a key pathway of reverse cholesterol transport implicated in atherosclerosis and coronary heart disease...
  88. ncbi Is dyslipidemia sustained during remission of nephrotic syndrome genetically determined? Evaluation of genetic polymorphisms of proteins involved in lipoprotein metabolism in children and adolescents with nephrotic syndrome
    Joanna Ksiazek
    Department of Nephrology, Kidney Transplantation and Arterial Hypertension Children s Memorial Health Institute, Warszawa, Poland
    Pol Arch Med Wewn 119:11-6. 2009
    ..In same patients lipid profile disturbances persist during nephrotic syndrome remission...
  89. pmc Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population
    Yongjian Lu
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Lipids Health Dis 12:85. 2013
    Hyperlipidaemia is a major risk factor for coronary artery disease (CAD) and cholesteryl ester transfer protein (CETP) gene polymorphisms are known to be associated with lipid profiles.
  90. ncbi Organization of the human cholesteryl ester transfer protein gene
    L B Agellon
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Biochemistry 29:1372-6. 1990
    The plasma cholesteryl ester transfer protein (CETP) catalyzes the transfer of phospholipids and neutral lipids between the lipoproteins. Thus, this protein may be important in modulating lipoprotein levels in the plasma...
  91. ncbi Cloning and sequencing of human cholesteryl ester transfer protein cDNA
    D Drayna
    Nature 327:632-4. 1987
    ..cholesteryl esters formed (largely to low- and very low-density lipoproteins) (LDL and VLDL) by a cholesteryl ester transfer protein (CETP); and removal of these lipoproteins, together with their cholesteryl ester content, by the ..
  92. ncbi Common cholesteryl ester transfer protein mutations, decreased HDL cholesterol, and possible decreased risk of ischemic heart disease: The Copenhagen City Heart Study
    B Agerholm-Larsen
    Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark
    Circulation 102:2197-203. 2000
    b>Cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl ester from HDL in exchange for triglycerides in apolipoprotein B-containing lipoproteins.
  93. ncbi Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. Genétique de la Nephropathie Diabétique Study Group. Données Ep
    S Hadjadj
    Medecine B, University Hospital, Angers, France
    Nephrol Dial Transplant 15:1971-6. 2000
    ..Genetic susceptibility contributes to the risk of diabetic nephropathy. Lipid disorders may favour diabetic nephropathy. Thus polymorphisms in lipid metabolism are candidates for the genetic component of risk for diabetic nephropathy...
  94. ncbi Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes
    S Meguro
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Atherosclerosis 156:151-6. 2001
    A polymorphism in the gene for cholesteryl ester transfer protein (CETP) has been reported to be associated with serum cholesterol levels and risk for atherosclerotic vascular diseases, and to clarify the relationship between the gene ..
  95. ncbi Relationship between TaqIB cholesteryl ester transfer protein gene polymorphism and macrovascular complications in Japanese patients with type 2 diabetes
    Isao Kawasaki
    Division of Metabolism, Endocrinology, and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Diabetes 51:871-4. 2002
    b>Cholesteryl ester transfer protein (CETP) is a key regulating factor of lipid metabolism, and the polymorphism of its gene may therefore be a candidate for modulating the lipid parameters, altering the susceptibility to atherosclerosis in ..
  96. ncbi A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 161:469-74. 2002
    Molecular variations in the gene coding for the cholesteryl ester transfer protein (CETP) such as the TaqIB polymorphism are associated with higher plasma high-density lipoprotein (HDL) concentration...
  97. ncbi Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women
    Leonie K Heilbronn
    Department of Physiology, University of Adelaide, South Australia, Australia
    Atherosclerosis 162:419-24. 2002
    Cholesterol ester transfer protein (CETP) facilitates reverse cholesterol transport via HDL-C and this activity may be increased in obese subjects...
  98. ncbi Cholesteryl ester transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency: Veterans Affairs HDL Cholesterol Intervention Trial
    Margaret E Brousseau
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University and Department of Medicine, New England Medical Center, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:1148-54. 2002
    We have previously reported that genetic variation at the cholesteryl ester transfer protein (CETP) TaqIB locus is correlated with plasma lipid levels and coronary heart disease (CHD) risk in the Framingham Offspring Study (FOS)...
  99. ncbi Elevation of plasma phospholipid transfer protein in transgenic mice increases VLDL secretion
    Jessica Lie
    Department of Biochemistry, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Lipid Res 43:1875-80. 2002
    Two lipid transfer proteins are active in human plasma, cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Mice by nature do not express CETP...
  100. ncbi Effect of HMG-CoA reductase inhibitor on plasma cholesteryl ester transfer protein activity in primary hypercholesterolemia: comparison among CETP/TaqIB genotype subgroups
    Hidetoshi Kotake
    Division of Endocrinology and Metabolism, Tohoku University School of Medicine, Miyagi, Japan
    J Atheroscler Thromb 9:207-12. 2002
    ..reductase inhibitors (statins) on the activity and concentration of plasma cholesterol ester transfer protein (CETP) in 30 hypercholesterolemic patients...
  101. ncbi Haplotype analyses of cholesteryl ester transfer protein gene promoter: a clue to an unsolved mystery of TaqIB polymorphism
    Hong Lu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, 920 8641, Kanazawa, Japan
    J Mol Med (Berl) 81:246-55. 2003
    b>Cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from HDL to triglyceride-rich lipoproteins...

Research Grants80

  1. Yuqing Eugene Chen; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that mediates the exchange of HDL cholesteryl esters (CE) for triglycerides in VLDL/LDL...
  2. Gang Ren; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Cholesteryl ester transfer protein (CETP) mediates the transfer of neutral lipids, including cholesteryl esters (CEs) and triglycerides (TGs), between high-density lipoproteins (HDL), low-density ..
  3. Carboxyl Ester Lipase Affects Hepatic HDL Metabolism
    PHILIP HOWLES; Fiscal Year: 2009
    ..3) Test the hypothesis that removing CEL from mice that express CETP (cholesteryl ester:triglyceride transfer protein) will increase lipid exchange between HDL and triglyceride-rich ..
  4. Gang Ren; Fiscal Year: 2016
    ..1 nm resolution map of a smaller single molecule, 53kDa CETP structure (PLoS One, 2012, 7:e30249, 1-19)...
  5. Genetics of Elevated High Density Lipoprotein Cholesterol
    DANIEL JAMES RADER; Fiscal Year: 2012
    ..The only proven molecular etiology of familial hyperalphalipoproteinemia is homozygous cholesteryl ester transfer protein (CETP) deficiency, which is found almost exclusively in Japan and led to the concept of ..
  6. Role of Genes in Exceptional Longevity in Humans
    NIR J BARZILAI; Fiscal Year: 2012
    ..age related increase (from ~5-10% to ~25-30%) in a single polymorphism in the Cholesterol ester transfer protein (CETP), Apolipoprotein C-3 (APOC-3), Adiponectin (ADIPOQ) genes...
  7. RICHARD LOUIS KLEIN; Fiscal Year: 2015
    ..We will determine if cholesteryl ester transfer protein (CETP) and the phospholipid transfer protein (PLTP) mediate S1P movement between lipoproteins...
  8. Mary G Sorci-Thomas; Fiscal Year: 2015
    ..binding cassette (ABC) transporter 1 (ABCA1)/ABCG1, lecithin cholesteryl acyl transferase (LCAT), cholesteryl ester transfer protein (CETP) and scavenger receptor class B1 (SR-B1) to mediate HDL-cholesterol release, esterification, ..
  9. DANIEL JAMES RADER; Fiscal Year: 2016
    ..HDL metabolism and atherogenesis, the interactions of EL and HL with the lipid transfer proteins cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), the implications and mechanisms of upregulation of ..
  10. HDL Structure and Metabolism During Inflammation
    Frederick C de Beer; Fiscal Year: 2011
    ..is that the acute phase phospholipases (group IIA sPLA2) act in concert with cholesterol ester transfer protein (CETP) to propel the apolipoproteins (SAA and apoA-l) associated with spherical HDL to distinct lipid-poor SAA or apoA-l ..
  11. Genetic and behavioral effects on high-density lipoprotein: The Look AHEAD Study
    Jeanne M McCaffery; Fiscal Year: 2013
    ..Specifically, we will determine whether HDL genes (CETP, LPL, LIPC, ABCA1 and LIPG) interact with lifestyle intervention in predicting change in HDL at year 1 and 4 of the ..
  12. W Sean Davidson; Fiscal Year: 2016
    ..three major HDL components: apolipoprotein A-II, lecithin:cholesterol acyl transferase (LCAT), and cholesteryl ester transfer protein (CETP)...
  13. Richard E Morton; Fiscal Year: 2014
    PROJECT SUMMARY/ABSTRACT Cholesteryl ester transfer protein (CETP) exchanges cholesteryl ester (CE) and triglyceride (TG) between lipoproteins and is well recognized as a regulator of plasma lipoprotein metabolism...
  14. PLASMA LIPOPROTEIN METABOLISM
    Robert Ryan; Fiscal Year: 1992
    ....
  15. Wolfgang Sadee; Fiscal Year: 2014
    ..a powerful link between genotype of proven function and clinical outcomes (examples: DRD2, TPH2, ACE, VKORC1, CETP, and CYP3A4). These results support a critical role for regulatory polymorphisms in drug response...
  16. Haplotype blocks across CETP and associations with CHD
    John Carlquist; Fiscal Year: 2004
    ..The cholesteryl ester transfer protein (CETP) mediates transfer of cholesteryl esters from HDL to LDL and very-LDL, possibly shifting the ..
  17. REGULATION OF PHOSPHOLIPID TRANSFER BETWEEN MEMBRANES
    John Nichols; Fiscal Year: 1990
    ....
  18. John H Griffin; Fiscal Year: 2014
    ..Aim 3 is centered on studies of the procoagulant activities of cholesteryl ester transfer protein (CETP)...
  19. Comparative Effects of Two Popular Diets in Veterans with the Metabolic Syndrome
    Michael Miller; Fiscal Year: 2013
    ..Therefore, this proposal has direct relevance to the VA health care mission. ..
  20. Rhoderick E Brown; Fiscal Year: 2014
    ....
  21. Soumya Swaminathan; Fiscal Year: 2014
    ..Specifically, we will study the role of genetic factors (single nucleotide polymorphisms in APOA5, APOC3, APOE, CETP and PLIN genes) in the development of metabolic complications, namely fat redistribution, insulin resistance and ..
  22. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ..HDL metabolism and atherogenesis, the interactions of EL and HL with the lipid transfer proteins cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), the implications and mechanisms of upregulation of ..
  23. BRADLEY JOHN WILLCOX; Fiscal Year: 2014
    ..predictors of healthy aging and longevity in a longitudinal study, (3) replicated a previous association of the CETP gene on longevity and extended the finding to include a role in healthy aging 4) and discovered a novel gene (..
  24. BRADLEY JOHN WILLCOX; Fiscal Year: 2014
    ..3) Found a gene (FOXO3A) with variants strongly associated with healthy aging and longevity;4) Replicated the CETP gene association with longevity and extended the finding to healthy aging...
  25. Statin-Berberine Combination Therapy in Hyperlipidemia
    Jingwen Liu; Fiscal Year: 2009
    ..The specific aims of this new proposal are to: 1) Use the human ApoB/CETP double trasnsgenic mice, which have a lipid profile similar to humans, as an vivo animal model to determine if the ..
  26. DYSREGULATION OF CETP AND LPL IN THE DIABETIC CYNOMOLGUS
    John Bagdade; Fiscal Year: 1993
    ..alters the surface properties of larger VLDL and enhances their affinity for cholesterol ester transfer protein (CETP)...
  27. EFFECTS OF IDDM ON LIPOPROTEIN REMODELING AND FUNCTION
    John Bagdade; Fiscal Year: 1993
    ..of the surface properties of larger VLDL particles, Increasing their affinity for cholesterol ester protein (CETP). This Interaction augments the exchange of neutral lipids between VLDL and HDL...
  28. GENETIC EPIDEMIOLOGY OF LIPOPROTEIN/LIPID LEVELS
    M Kamboh; Fiscal Year: 2000
    ..variation in nine candidate genes involved in lipid metabolism [APO(a), APOD, hepatic lipase (HL), cholesteryl ester transfer protein (CETP), LDL receptor related protein (LRP), 3- hydroxy-3 methyl glutryl-coenzyme A (HMG COA), VLDL-..
  29. Risk Burden of Lipoprotein Metabolic Gene Haplotypes
    Jeffrey Anderson; Fiscal Year: 2007
    ..and 3' regulatory regions of 6 genes that play key roles in lipoprotein transport and metabolism (ABCA1, CETP, LCAT, HL, LPL, SRB1); introns will be examined for 2 of the genes (CETP, LPL)...
  30. LIPID HYDROPEROXIDE CYTOTOXICITY AND DETOXIFICATION
    ALBERT GIROTTI; Fiscal Year: 2007
    ..By exploring this new dimension in LOOH bioreactivity, these studies will provide valuable new insights into the cytopathological effects of these species. ..
  31. CHARACTERIZATION OF MEMBRANE LIPID DOMAINS
    Ruth Welti; Fiscal Year: 1990
    ..The chemical and physical studies described here will be integrated into a more clearly defined model of membrane structure, which, in the long term, will provide a basis to relate membrane lipid topology to membrane function...
  32. Novel Transgenic Rabbit Model for Cardiovascular Disease
    Fuliang Du; Fiscal Year: 2009
    ..In this project, we propose to produce Cholesterol Ester Transfer Protein (CETP) knockout rabbits...
  33. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2004
    ..underlying the changes in LDL size will also be studied by measuring hepatic lipase activity, cholesteryl ester transfer protein (CETP) activity, triglyceride (TG) levels, body fat distribution and the hepatic lipase gene ..
  34. INTRACELLULAR TRIGLYCERIDE TRANSPORT AND METABOLISM
    John Wetterau; Fiscal Year: 1990
    ..These studies will extend previous studies designed to determine if the transfer properties of MTP are consistent with a protein involved in lipoprotein biogenesis...
  35. STRUCTURE/FUNCTION OF HIGH DENSITY LIPOPROTEINS
    Alan Tall; Fiscal Year: 2001
    ..The plasma cholesteryl ester transfer protein (CETP) mediates the transfer of CE from HDL to the triglyceride-rich lipoproteins...
  36. REVERSE CHOLESTEROL TRANSPORT
    Andras Lacko; Fiscal Year: 1993
    ..system, HDL functions jointly with the enzyme lecithin:cholesterol acyltransferase (LCAT) and the cholesteryl ester transfer protein (CETP) in a system to facilitate the clearance of cholesterol from the plasma...
  37. EXERCISE AND TYPE II DIABETES--ADHERENCE AND CVD RISK
    GEORGE GOODRICK; Fiscal Year: 2000
    ..Outcomes will include cardiovascular risk profile (CETP, NEFA, lipids) physical activity, BMI, indicators of diabetic health, and exercise self-efficacy...
  38. STRUCTURAL BASIS OF GANGLIOSIDE RECOGNITION
    Christine Wright; Fiscal Year: 2003
    ....
  39. HIGH DENSITY LIPOPROTEIN SUBSPECIES AND CORONARY DISEASE
    Bela Asztalos; Fiscal Year: 2003
    ..The investigators state that these studies should provide better understanding about the diagnosis and treatment of HDL deficiency for the prevention of CHD. ..
  40. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..abstract_text> ..
  41. MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCY
    ERNST SCHAEFER; Fiscal Year: 2009
    ..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
  42. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..plasma betasitosterol, a marker of cholesterol absorption as well as decrease cholesterol ester transfer protein (CETP) mass...
  43. Quantitation of In Vivo Human Lutein Metabolism
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..Therefore, the purpose of this study is to determine how the human body uses lutein and other related compounds. ..
  44. Atherogenic Effects of Tyrosine Oxidation in HDL
    John Oram; Fiscal Year: 2004
    ....
  45. DYNAMIC AND KINETIC BEHAVIOR OF FOLATE METABOLISM
    Andrew Clifford; Fiscal Year: 2005
    ..We will determine the in vivo kinetic behavior of a tracer dose of folate in blood, urine, and stool. We will then compare the behavior of folate metabolism (functional endpoint) among the various genotypes. ..
  46. COMPARATIVE GENOMIC ANALYSIS OF CARDIOVASCULAR GENE REGU
    Ronald Krauss; Fiscal Year: 2003
    ..6) The establishment of an educational program for cardiovascular researchers in the use of genomic databases and tools. ..
  47. Quantitation of Tocopherol Metabolism in Humans
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..Particular attention will be directed to the absorption phase. The results are expected to provide information about vitamin E biopotency and eventually improved Dietary Recommendations. ..
  48. IN VIVO DYNAMIC OF BETA-CAROTENE METABOLISM IN HUMANS
    Andrew Clifford; Fiscal Year: 2006
    ....
  49. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2009
    ..abstract_text> ..
  50. Functional aspects of SREBP1c in intact skeletal muscle
    Paul MacLean; Fiscal Year: 2007
    ....
  51. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2009
    ..Our proposal will advance understanding of the role of vascular growth factors in initiating and promoting vascular stiffness, LV dysfunction and HTN. ..
  52. HYPERTENSION / ATHEROSCLEROSIS PARADIGMS
    VICTORIA HERRERA; Fiscal Year: 2002
    ..a transgenic hyperlipidemia- genetic hypertensive rat model by hepatic over-expression of human cholesteryl ester transfer protein (hCETP) in Dahl salt-sensitive (S) rats...
  53. THE ROLE OF PLASMA SPHINGOMYELIN IN ATHEROSCLEROSIS
    Xian Cheng Jiang; Fiscal Year: 2004
    ..If the enrichment of SM in plasma has pro-atherogenic activity, as anticipated, then the inhibition of SPT, the key enzyme for SM biosynthesis, could be an important treatment for atherosclerosis. ..
  54. Inhibition of Alzheimer's Beta-Amyloid Fibril Formation
    Duy Hua; Fiscal Year: 2009
    ..However, soluble oligomeric Abeta showed high neuronal toxicity. Inhibition of the formation of these toxic soluble Abeta oligomers would provide therapeutics for AD. ..
  55. The Role of Tenascin in Neointimal Formation
    Prediman Shah; Fiscal Year: 2009
    ..Aim 3. TN deficiency promotes neointimal formation after vascular injury. Aim 4. TN deficiency per se is sufficient for neointimal formation. ..
  56. Ventricular Vascular Coupling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2009
    ..LV and vascular stiffness measures at prior examinations facilitate the evaluation of longitudinal changes and associated risk. ..
  57. ABCA7: Cellular Functions and Role in Atherosclerosis
    Alan Tall; Fiscal Year: 2009
    ..Overall, this proposal will elucidate the in vivo functions of a novel ABC transporter and its role in macrophage clearance of apoptotic cells, inflammation and atherogenesis. ..
  58. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2004
    ..The proposed translational research will likely yield seminal information that could directly improve our efforts to prevent CHF through the biochemical assessment of cardiac ECM remodeling. ..
  59. Targeting Apolipoprotein E4-related Neuropathology
    Robert Mahley; Fiscal Year: 2004
    ..Ultimately, it will be our goal to take "hits" to lead compounds that may give rise to a drug that prevents or retards apoE4-related neuropathology. ..
  60. Transport and Metabolism of Fatty Acids in Adipocytes
    James Hamilton; Fiscal Year: 2004
    ..We can then address a key question for formulation of new therapies for obesity: does FFA transport affect the partitioning of FFA between storage and utilization as fuel? ..
  61. Postprandial Lipemia and Endothelial Function In ACCORD
    Henry Ginsberg; Fiscal Year: 2004
    ....
  62. A functional array for signature of breast cancer
    Xin Jiang; Fiscal Year: 2005
    ....
  63. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2002
    ..1%). Additionally, a detectable reduction in breast cancer risk as small as 1.5% per mile run in women is calculated, which is below the 1.7% reduction in risk estimated from other published data. ..
  64. EFFECT OF DIETARY LIPIDS ON THE FUNCTION OF CHYLOMICRONS
    Byung Hong Chung; Fiscal Year: 2002
    ..the reactions catalyzed by lecithin cholesterol acyltransferase (LCAT) and/or cholesterylester transfer proteins (CETP) and by influencing the rate of the clearance of CH-enriched chylomicron remnants from circulating blood...
  65. TRANSGENIC RAT MODELS OF ALZHEIMER'S DISEASE
    VICTORIA HERRERA; Fiscal Year: 2002
    ..abstract_text> ..
  66. The Family Blood Pressure Program (SAPPHIRe Network)
    JESS CURB; Fiscal Year: 2007
    ..unreadable] (End of Abstract) [unreadable] [unreadable]..
  67. SCAVENGER RECEPTOR B1 AND HDL METABOLISM
    Alan Tall; Fiscal Year: 2005
    ..The work will provide crucial insights into the cellular mechanisms underlying the final step of reverse cholesterol transport. The findings will be relevant to the relationship between HDL, atherosclerosis and gallstone formation. ..
  68. Transcription indication reporter array technology
    Xin Jiang; Fiscal Year: 2004
    ..The expressed tag sequences can then be determined with an array assay. With this technology, the simultaneous activation of multiple transcription factors in signal transduction pathways in vivo can be monitored at once. ..
  69. MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSIS
    Daniel Rader; Fiscal Year: 2004
    ..These studies will provide novel insights into the mechanisms of PI-associated dyslipidemia and atherosclerosis. ..
  70. CELLULAR BASIS OF ANTIATHEROGENESIS BY APOLIPOPROTEIN E
    Daniel Rader; Fiscal Year: 2001
    ..These studies will provide greater understanding of the role of the local inflammatory response in atherosclerosis and its regulation by apoE. ..
  71. Genetics of Oxidative Stress in Ventricular Remodeling
    Vasan Ramachandran; Fiscal Year: 2003
    ....
  72. Genetic Determinants: Low HDL, High Triglycerides, Obes*
    Robert Mahley; Fiscal Year: 2003
    ....
  73. ASYMMETRIC DISTRIBUTION OF CHOLESTEROL IN MEMBRANES
    Friedhelm Schroeder; Fiscal Year: 2010
    ..If this process were understood, new therapeutic targets for increasing cholesterol efflux for lowering plasma cholesterol could potentially be developed. ..
  74. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..These mechanistic insights may suggest new treatments for vulnerable human plaques such as LXR activators, CatK inhibitors or inhibitors of RANK signaling. ..
  75. Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan
    J Curb; Fiscal Year: 2006
    ..Better understanding the reasons for the low Japanese rates may help us find new methods for prevention of CHD in all populations. ..
  76. Exercise and the Metabolic Syndrome with Weight Regain
    Tom Thomas; Fiscal Year: 2009
    ..abstract_text> ..
  77. Aldosterone in Vascular Remodeling and Dysfunction
    Vasan Ramachandran; Fiscal Year: 2008
    ..Activities for career development of the candidate are also planned in the areas of proteomics and genetic epidemiology. ..