chromogranin A

Summary

Gene Symbol: chromogranin A
Description: chromogranin A
Alias: CGA, chromogranin-A, SP-I, betagranin (N-terminal fragment of chromogranin A), catestatin, chromofungin, parathyroid secretory protein 1, pituitary secretory protein I
Species: human
Products:     chromogranin A

Top Publications

  1. Vaingankar S, Li Y, Biswas N, Gayen J, Choksi S, Rao F, et al. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010;28:817-25 pubmed publisher
    The phenotype of the chromogranin A (Chga) null (knockout) mouse is hypertensive. However, hypertensive humans and spontaneously hypertensive rats display elevated CHGA expression...
  2. Lawrence B, Gustafsson B, Kidd M, Pavel M, Svejda B, Modlin I. The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am. 2011;40:111-34, viii pubmed publisher
    b>Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs)...
  3. Montero Hadjadje M, Vaudry H, Turquier V, Leprince J, Do Rego J, Yon L, et al. Localization and characterization of evolutionarily conserved chromogranin A-derived peptides in the rat and human pituitary and adrenal glands. Cell Tissue Res. 2002;310:223-36 pubmed
    b>Chromogranin A (CgA) is a neuroendocrine protein that undergoes proteolytic cleavage in secretory granules...
  4. Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T. Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. Mol Biol Cell. 2002;13:3388-99 pubmed
    b>Chromogranin A (CgA) is transported restrictedly to secretory granules in neuroendocrine cells. In addition to pH- and Ca(2+)-dependent aggregation, CgA is known to bind to a number of vesicle matrix proteins...
  5. Jiang Q, Taupenot L, Mahata S, Mahata M, O Connor D, Miles L, et al. Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release. J Biol Chem. 2001;276:25022-9 pubmed
    b>Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for ..
  6. Strub J, Goumon Y, Lugardon K, Capon C, Lopez M, Moniatte M, et al. Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules. J Biol Chem. 1996;271:28533-40 pubmed
    ..Here, we characterize a large natural fragment, corresponding to chromogranin A 79-431, that inhibits growth of both Gram-positive and Gram-negative bacteria...
  7. Yao J, Pavel M, Phan A, Kulke M, Hoosen S, St Peter J, et al. Chromogranin A and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus. J Clin Endocrinol Metab. 2011;96:3741-9 pubmed publisher
    ..b>Chromogranin A (CgA) and neuron-specific enolase (NSE) are considered general biomarkers of these tumors...
  8. Chou W, Hung Y, Hsu J, Chen J, Lu C, Hwang T, et al. Chromogranin A is a reliable biomarker for gastroenteropancreatic neuroendocrine tumors in an Asian population of patients. Neuroendocrinology. 2012;95:344-50 pubmed publisher
    To evaluate the significance of plasma chromogranin A (CgA) levels in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET) in terms of disease status and treatment responses.
  9. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung M, et al. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009;20:1623-32 pubmed publisher
    b>Chromogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells...
  10. Lillie E, Mahata M, Khandrika S, Rao F, Bundey R, Wen G, et al. Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. Circulation. 2007;115:2282-91 pubmed
    ..b>Chromogranin A (CHGA) regulates the storage and release of catecholamines and may have direct actions on the microvasculature...

Detail Information

Publications62

  1. Vaingankar S, Li Y, Biswas N, Gayen J, Choksi S, Rao F, et al. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010;28:817-25 pubmed publisher
    The phenotype of the chromogranin A (Chga) null (knockout) mouse is hypertensive. However, hypertensive humans and spontaneously hypertensive rats display elevated CHGA expression...
  2. Lawrence B, Gustafsson B, Kidd M, Pavel M, Svejda B, Modlin I. The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am. 2011;40:111-34, viii pubmed publisher
    b>Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs)...
  3. Montero Hadjadje M, Vaudry H, Turquier V, Leprince J, Do Rego J, Yon L, et al. Localization and characterization of evolutionarily conserved chromogranin A-derived peptides in the rat and human pituitary and adrenal glands. Cell Tissue Res. 2002;310:223-36 pubmed
    b>Chromogranin A (CgA) is a neuroendocrine protein that undergoes proteolytic cleavage in secretory granules...
  4. Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T. Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. Mol Biol Cell. 2002;13:3388-99 pubmed
    b>Chromogranin A (CgA) is transported restrictedly to secretory granules in neuroendocrine cells. In addition to pH- and Ca(2+)-dependent aggregation, CgA is known to bind to a number of vesicle matrix proteins...
  5. Jiang Q, Taupenot L, Mahata S, Mahata M, O Connor D, Miles L, et al. Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release. J Biol Chem. 2001;276:25022-9 pubmed
    b>Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for ..
  6. Strub J, Goumon Y, Lugardon K, Capon C, Lopez M, Moniatte M, et al. Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules. J Biol Chem. 1996;271:28533-40 pubmed
    ..Here, we characterize a large natural fragment, corresponding to chromogranin A 79-431, that inhibits growth of both Gram-positive and Gram-negative bacteria...
  7. Yao J, Pavel M, Phan A, Kulke M, Hoosen S, St Peter J, et al. Chromogranin A and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus. J Clin Endocrinol Metab. 2011;96:3741-9 pubmed publisher
    ..b>Chromogranin A (CgA) and neuron-specific enolase (NSE) are considered general biomarkers of these tumors...
  8. Chou W, Hung Y, Hsu J, Chen J, Lu C, Hwang T, et al. Chromogranin A is a reliable biomarker for gastroenteropancreatic neuroendocrine tumors in an Asian population of patients. Neuroendocrinology. 2012;95:344-50 pubmed publisher
    To evaluate the significance of plasma chromogranin A (CgA) levels in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET) in terms of disease status and treatment responses.
  9. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung M, et al. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009;20:1623-32 pubmed publisher
    b>Chromogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells...
  10. Lillie E, Mahata M, Khandrika S, Rao F, Bundey R, Wen G, et al. Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. Circulation. 2007;115:2282-91 pubmed
    ..b>Chromogranin A (CHGA) regulates the storage and release of catecholamines and may have direct actions on the microvasculature...
  11. Savilov P. [Influence of partial hepatectomie on ammoniumdetoxications function of liver at chronic tetrachlorcarbon hepatitis]. Patol Fiziol Eksp Ter. 2017;61:61-6 pubmed
    ..Conclusions. The obtained results show that CGA on the background of chronic hepatitis increases the pathological impact of CCl4 on amniocentesis liver function.
  12. Naveed M, Hejazi V, Abbas M, Kamboh A, Khan G, Shumzaid M, et al. Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomed Pharmacother. 2017;97:67-74 pubmed publisher
    ..Chlorogenic Acid (CGA, 3-CQA) is a most abundant isomer among caffeoylquinic acid isomers (3-, 4-, and 5-CQA), that currently known as 5-..
  13. Conroy S, Parker S. Acute geriatrics at the front door. Clin Med (Lond). 2017;17:350-353 pubmed publisher
    ..Comprehensive geriatric assessment (CGA) is an evidence-based approach to improving their outcomes, as well as improving service outcomes...
  14. Schmidt H, Boese S, Lampe K, Jordan K, Fiedler E, Muller Werdan U, et al. Trans sectoral care of geriatric cancer patients based on comprehensive geriatric assessment and patient-reported quality of life - Results of a multicenter study to develop and pilot test a patient-centered interdisciplinary care concept for geriatr. J Geriatr Oncol. 2017;8:262-270 pubmed publisher
    ..patients with cancer we developed an interdisciplinary care program based on comprehensive geriatric assessment (CGA) and patient-reported HRQOL comprising tailored supportive measures and telephone-based counseling during 6month ..
  15. Dai L, Zhou X, Kausar S, Abbas M, Wu L, Zhou H. Mitochondrial genome of Diaphania indica(saunders) (Lepidoptera: Pyraloidea) and implications for its phylogeny. Int J Biol Macromol. 2017;: pubmed publisher
    ..All of the 12 PCGs initiate with canonical start codon (ATN), except for coxI that initiate with CGA. The A+T rich element of D. indica is 467bp long and contains many features common to Pyraloidea insects...
  16. Ballham S, Buxton S, Camacho R, Sinclair A, Dyer C, Jakeman N. 36 Frailty flying squad: an emergency department focussed acute care of the elderly service DR genevieve robson, royal united hospital NHS foundation trust. Emerg Med J. 2017;34:A885-A886 pubmed publisher
    ..There is evidence that multidisciplinary care and early Comprehensive Geriatric Assessment (CGA) improves outcomes for older patients, reducing readmissions, long term care, greater satisfaction and lower costs...
  17. Liu L, Ding W, Li R, Ye X, Zhao J, Jiang J, et al. Plasma levels and diagnostic value of catestatin in patients with heart failure. Peptides. 2013;46:20-5 pubmed publisher
    b>Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF...
  18. Kakita K, Tsubouchi H, Adachi M, Takehana S, Shimazu Y, Takeda M. Local subcutaneous injection of chlorogenic acid inhibits the nociceptive trigeminal spinal nucleus caudalis neurons in rats. Neurosci Res. 2017;: pubmed publisher
    Acute administration of chlorogenic acid (CGA) in vitro was recently shown to modulate potassium channel conductance and acid-sensing ion channels (ASICs) in the primary sensory neurons; however, in vivo peripheral effects of CGA on the ..
  19. Tchaou M, Darre T, Folligan K, Sabi A, Sonhaye L, Boume A, et al. Primary Neuroendocrine Breast Carcinoma in a 13-Year-Old Girl: Ultrasonography and Pathology Findings. Case Rep Radiol. 2017;2017:7915806 pubmed publisher
    ..According to immunohistochemistry performed on paraffin blocks in France, infiltrating ductal carcinoma with a strong neuroendocrine component was confirmed by CD56, CD57, and chromogranin A markers.
  20. Komo T, Kohashi T, Nakashima A, Ohmori I, Hihara J, Mukaida H, et al. Mixed adenoneuroendocrine carcinoma of the distal bile duct: A case report. Int J Surg Case Rep. 2017;39:203-207 pubmed publisher
    ..The non-adenocarcinoma component stained positive for synaptophysin and chromogranin A. The Ki-67 labeling index was 37%...
  21. Modlin I, Kidd M, Filosso P, Roffinella M, Lewczuk A, Cwikla J, et al. Molecular strategies in the management of bronchopulmonary and thymic neuroendocrine neoplasms. J Thorac Dis. 2017;9:S1458-S1473 pubmed publisher
    ..most often secreting ACTH (40% of tumors) but both tumor groups share secretion of common biomarkers including chromogranin A and 5-HIAA. Consistently effective and accurate circulating biomarkers are, however, currently unavailable...
  22. Zhang D, Lavaux T, Voegeli A, Lavigne T, Castelain V, Meyer N, et al. Prognostic value of chromogranin A at admission in critically ill patients: a cohort study in a medical intensive care unit. Clin Chem. 2008;54:1497-503 pubmed publisher
    ..The acute response to stress causes the release of catecholamines from the adrenal medulla accompanied by chromogranin A (CGA)...
  23. Espinosa I, De Leo A, D Angelo E, Rosa Rosa J, Corominas M, González A, et al. Dedifferentiated endometrial carcinomas with neuroendocrine features: a clinicopathologic, immunohistochemical, and molecular genetic study. Hum Pathol. 2017;: pubmed publisher
    ..we have analyzed the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, b-catenin, SMARCB1, synaptophysin, chromogranin A, and CD56) and mutational status (PTEN, KRAS, PIK3CA, TP53 and POLE) of 4 dedifferentiated endometrial ..
  24. Stefanello N, Schmatz R, Pereira L, Cardoso A, Passamonti S, Spanevello R, et al. Effects of chlorogenic acid, caffeine and coffee on components of the purinergic system of streptozotocin-induced diabetic rats. J Nutr Biochem. 2016;38:145-153 pubmed publisher
    We evaluated the effect of chlorogenic acid (CGA), caffeine (CA) and coffee (CF) on components of the purinergic system from the cerebral cortex and platelets of streptozotocin-induced diabetic rats...
  25. Takatsuji K, Sugimoto Y, Ishizaki S, Ozaki Y, Matsuyama E, Yamaguchi Y. The effects of examination stress on salivary cortisol, immunoglobulin A, and chromogranin A in nursing students. Biomed Res. 2008;29:221-4 pubmed
    This study aimed to assess the effects of examination stress on salivary cortisol, immunoglobulin A (IgA), and chromogranin A (CgA) in nursing students...
  26. Rajasekaran T, Tan T, Ong W, Koo K, Chan L, Poon D, et al. Comprehensive Geriatric Assessment (CGA) based risk factors for increased caregiver burden among elderly Asian patients with cancer. J Geriatr Oncol. 2016;7:211-8 pubmed publisher
    This study aims to identify Comprehensive Geriatric Assessment (CGA) based risk factors to help predict caregiver burden among elderly patients with cancer.
  27. Cindolo L, Franco R, Cantile M, Schiavo G, Liguori G, Chiodini P, et al. NeuroD1 expression in human prostate cancer: can it contribute to neuroendocrine differentiation comprehension?. Eur Urol. 2007;52:1365-73 pubmed
    ....
  28. Bozdogan O, Atasoy P, Bozdogan N, Erekul S, Batislam E, Yilmaz E, et al. BAG-1 expression in hyperplastic and neoplastic prostate tissue: is there any relationship with BCL-related proteins and androgen receptor status?. Tumori. 2005;91:539-45 pubmed
    ..function and distribution of BAG-1 protein in hyperplastic and neoplastic prostate tissue and establish the relationship between this protein and BCL-related proteins (BCL-2 and BAX), androgen receptor (AR) expression and chromogranin A.
  29. Hu Y, Malone J, Fagan A, Townsend R, Holtzman D. Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. Mol Cell Proteomics. 2005;4:2000-9 pubmed
    ..These results validate our method of identifying differences in proteomic profiles of CSF samples and have important implications for the design of CSF biomarker studies for AD and other central nervous system disorders. ..
  30. Strub J, Sorokine O, Van Dorsselaer A, Aunis D, Metz Boutigue M. Phosphorylation and O-glycosylation sites of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities. J Biol Chem. 1997;272:11928-36 pubmed
    Bovine adrenal medullary chromogranin A, the major soluble component of chromaffin granules, is a phosphorylated glycoprotein...
  31. Rydning A, Lyng O, Adamsen B, Falkmer S, Sandvik A, Grønbech J. Mast cells are involved in the gastric hyperemic response to acid back diffusion via release of histamine. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1061-9 pubmed
    ..Mucosal mast cells (MMC), submucosal connective tissue mast cells (CTMC), and chromogranin A-immunoreactive cells (CgA IR) were assessed morphometrically. After mucosal exposure to 1...
  32. Helle K, Metz Boutigue M, Cerra M, Angelone T. Chromogranins: from discovery to current times. Pflugers Arch. 2017;: pubmed publisher
    ..In the mid-1960s, the enzymatically inactive, major core protein, chromogranin A was shown to be exocytotically discharged from the stimulated adrenal gland in parallel with the co-stored ..
  33. Mahata S, Kiranmayi M, Mahapatra N. Catestatin: A Master Regulator of Cardiovascular Functions. Curr Med Chem. 2017;: pubmed publisher
    ..Hypertension is a common contributor to morbidity and mortality from CVD. The plasma concentration of chromogranin A (CgA) is elevated in patients with CVD as well as patients with established human essential hypertension and ..
  34. Mahapatra N, Taupenot L, Courel M, Mahata S, O Connor D. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Biochemistry. 2008;47:7167-78 pubmed publisher
    ..Recent studies suggest an important role of chromogranin A (CHGA) in the regulated secretory pathway in neuroendocrine cells, but the mechanism by which CHGA enters the ..
  35. Sciarra A. Neuroendocrine differentiation in prostate adenocarcinoma. Eur Urol. 2007;52:1373 pubmed