CLEC7A

Summary

Gene Symbol: CLEC7A
Description: C-type lectin domain containing 7A
Alias: BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2, C-type lectin domain family 7 member A, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12, C-type lectin superfamily member 12, DC-associated C-type lectin 1, beta-glucan receptor, dectin-1, dendritic cell-associated C-type lectin-1, lectin-like receptor 1
Species: human

Top Publications

  1. pmc Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    Iliyan D Iliev
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Science 336:1314-7. 2012
  2. pmc Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection
    Juan Sainz
    Genomic Oncology Area, GENYO, Pfizer University of Granada Andalusian Government Centre for Genomics and Oncological Research, Granada, Spain
    PLoS ONE 7:e32273. 2012
  3. pmc Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway
    Daniela C Ifrim
    Department of Experimental Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands
    J Immunol 190:4129-35. 2013
  4. doi Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1
    Sam Willcocks
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hatfield, United Kingdom
    J Leukoc Biol 94:449-58. 2013
  5. doi Expression and function of dectin-1 is defective in monocytes from patients with systemic lupus erythematosus and rheumatoid arthritis
    Claudia Salazar-Aldrete
    Department of Immunology, Facultad de Medicina, UASLP, San Luis Potosi, SLP, Mexico
    J Clin Immunol 33:368-77. 2013
  6. pmc Dectin-1 is essential for reverse transcytosis of glycosylated SIgA-antigen complexes by intestinal M cells
    Nicolas Rochereau
    GIMAP EA3064, INSERM CIE3 Vaccinology, Universite de Lyon, Saint Etienne, France
    PLoS Biol 11:e1001658. 2013
  7. doi Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling
    Makoto Ohtani
    Division of Oral Molecular Microbiology, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Kita 13, Nishi 7, Kita ku, Sapporo 060 8586, Japan
    Cell Microbiol 14:40-57. 2012
  8. pmc MBL-mediated opsonophagocytosis of Candida albicans by human neutrophils is coupled with intracellular Dectin-1-triggered ROS production
    Dongsheng Li
    Center for Infectious Skin Diseases, Department of Dermatology, No 1 Hospital of Wuhan, Wuhan, China
    PLoS ONE 7:e50589. 2012
  9. pmc Vimentin is an endogenous ligand for the pattern recognition receptor Dectin-1
    Praveena S Thiagarajan
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Cardiovasc Res 99:494-504. 2013
  10. doi Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells
    Marco A Pires-Lapa
    Laboratory of Chronopharmacology, Institute of Bioscience, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Pineal Res 55:240-6. 2013

Research Grants

  1. David M Underhill; Fiscal Year: 2016
  2. The Role of Genetic Variation in the Fungal/Host Interaction
    Gerald R Fink; Fiscal Year: 2012
  3. Dectin-1 and Immunity Against Pneumocystis Carinii
    Chad Steele; Fiscal Year: 2009
  4. Epithelial Regulation of Th2 Immune Responses in the Lung
    Marsha Wills-Karp; Fiscal Year: 2013
  5. Jatin M Vyas; Fiscal Year: 2016
  6. Mechanisms of Immune Modulation Mediated by Yeast-derived Particulate Beta-Glucan
    Jun Yan; Fiscal Year: 2012
  7. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
  8. Enhancing TB vaccine with gene silencing
    Jinhee Lee; Fiscal Year: 2013
  9. Non-CD4 Host defense against P. carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2013
  10. Host response to P. carinii in neonatal mice
    Beth A Garvy; Fiscal Year: 2013

Patents

  1. Macrophage receptor agonist or antagonist

Detail Information

Publications212 found, 100 shown here

  1. pmc Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    Iliyan D Iliev
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Science 336:1314-7. 2012
    ..In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis...
  2. pmc Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection
    Juan Sainz
    Genomic Oncology Area, GENYO, Pfizer University of Granada Andalusian Government Centre for Genomics and Oncological Research, Granada, Spain
    PLoS ONE 7:e32273. 2012
    ....
  3. pmc Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway
    Daniela C Ifrim
    Department of Experimental Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands
    J Immunol 190:4129-35. 2013
    ..albicans is nevertheless required. In conclusion, C. albicans is able to modify cytokine responses to TLR ligands and colonizing bacteria, which is likely to impact the inflammatory reaction during mucosal diseases...
  4. doi Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1
    Sam Willcocks
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hatfield, United Kingdom
    J Leukoc Biol 94:449-58. 2013
    ....
  5. doi Expression and function of dectin-1 is defective in monocytes from patients with systemic lupus erythematosus and rheumatoid arthritis
    Claudia Salazar-Aldrete
    Department of Immunology, Facultad de Medicina, UASLP, San Luis Potosi, SLP, Mexico
    J Clin Immunol 33:368-77. 2013
    ..Monocytes from patients with RA also showed a diminished expression, and a defective function of dectin-1. Our data suggest that dectin-1 receptor defects could contribute to the pathogenesis of autoimmune inflammatory conditions...
  6. pmc Dectin-1 is essential for reverse transcytosis of glycosylated SIgA-antigen complexes by intestinal M cells
    Nicolas Rochereau
    GIMAP EA3064, INSERM CIE3 Vaccinology, Universite de Lyon, Saint Etienne, France
    PLoS Biol 11:e1001658. 2013
    ..Having deciphered the mechanisms leading to specific targeting of SIgA-based Ag complexes paves the way to the use of such a vehicle for mucosal vaccination against various infectious diseases...
  7. doi Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling
    Makoto Ohtani
    Division of Oral Molecular Microbiology, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Kita 13, Nishi 7, Kita ku, Sapporo 060 8586, Japan
    Cell Microbiol 14:40-57. 2012
    ....
  8. pmc MBL-mediated opsonophagocytosis of Candida albicans by human neutrophils is coupled with intracellular Dectin-1-triggered ROS production
    Dongsheng Li
    Center for Infectious Skin Diseases, Department of Dermatology, No 1 Hospital of Wuhan, Wuhan, China
    PLoS ONE 7:e50589. 2012
    ..These data demonstrate that MBL has an ability to mediate the opsonophagocytosis of Candida albicans by human neutrophils independent of complement activation, which is coupled with intracellular Dectin-1-triggered ROS production...
  9. pmc Vimentin is an endogenous ligand for the pattern recognition receptor Dectin-1
    Praveena S Thiagarajan
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Cardiovasc Res 99:494-504. 2013
    ..Our hypothesis was that inflammation generates endogenous ligands for Dectin-1 that activate O₂⁻ production and thereby contributes to atherogenesis...
  10. doi Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells
    Marco A Pires-Lapa
    Laboratory of Chronopharmacology, Institute of Bioscience, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Pineal Res 55:240-6. 2013
    ..Given that these cells are present in human colostrum for 4 or 5 days after birth, this mechanism may be relevant for the protection of infant health. ..
  11. doi Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles
    Robin van Bruggen
    Sanquin Research, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Mol Immunol 47:575-81. 2009
    ..In summary, our data show that Dectin-1, although indispensable for recognition of beta-glucan-bearing particles in mice, is not the major receptor for yeast particles in human neutrophils...
  12. doi Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN
    Elena Zenaro
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    J Leukoc Biol 86:1393-401. 2009
    ..Dectin-1 engagement by Mtb enables DC to promote a Th1/Th17 response, whereas DC-SIGN and MR costimulation limits dectin-1-dependent Th17 generation and favors a Th1 response, probably by interfering with release of cytokines...
  13. doi Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
    ..These findings contribute to a better understanding of the host response to mycobacteria and provide the opportunity to explore potential, novel, therapeutic strategies against TB...
  14. pmc Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
    Mohlopheni J Marakalala
    Institute of Infectious Diseases and Molecular Medicine, Division of Immunology, CLS, University of Cape Town, Cape Town, South Africa
    Mamm Genome 22:55-65. 2011
    ..Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease...
  15. pmc Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia
    Diana C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 204:1138-45. 2011
    ..The role of genetic variation of DECTIN-1 and CARD9 genes on the susceptibility to candidemia is unknown...
  16. ncbi Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1
    K Yokota
    Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Gene 272:51-60. 2001
    ..Our results indicate that human DECTIN-1 shares many features with mouse dectin-1, including the generation of neck domain-lacking isoforms, which may down-regulate the co-stimulatory function of dectin-1...
  17. doi TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis
    Camila Vicente Bonfim
    Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas UNICAMP, 13083 970 Campinas, SP, Brazil
    Med Mycol 47:722-33. 2009
    ..With these attributes the low virulence strain of P. brasiliensis would induce a controlled immune response beneficial to the host...
  18. ncbi Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning
    K Ariizumi
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9069, USA
    J Biol Chem 275:20157-67. 2000
    ..Not only do these results document the efficacy of subtractive cDNA cloning for the identification of unique genes expressed by DC, they also provide a framework for studying the physiological function of dectin-1...
  19. ncbi Immune recognition. A new receptor for beta-glucans
    G D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 413:36-7. 2001
    ..1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans...
  20. ncbi Nontypeable Haemophilus influenzae activates human eosinophils through beta-glucan receptors
    Irini Lazou Ahrén
    Department of Medical Microbiology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Am J Respir Cell Mol Biol 29:598-605. 2003
    ..This points to possible pathophysiologic mechanisms involving innate recognition of NTHi by eosinophils during infection of the airways, thus promoting inflammation in chronic pulmonary disease...
  21. ncbi CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells
    Adriana R Mantegazza
    Fundacion Instituto Leloir, Av Patricias Argentinas 435, 1405 Capital Federal, Argentina
    Blood 104:1183-90. 2004
    ..However, only CD63 would intervene in the internalization of complex antigens...
  22. ncbi The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells
    Janet A Willment
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 35:1539-47. 2005
    ....
  23. ncbi hDectin-1 is involved in uptake and cross-presentation of cellular antigens
    Markus M Weck
    Department of Internal Medicine II, Division of Oncology, Hematology, Immunology, Rheumatology and Pneumology, University of Tubingen, Tubingen, Germany
    Blood 111:4264-72. 2008
    ....
  24. doi Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MC Amsterdam, The Netherlands
    Nat Immunol 10:203-13. 2009
    ..Thus, dectin-1 activates two independent signaling pathways, one through Syk and one through Raf-1, to induce immune responses...
  25. doi Innate immune responses to Mycobacterium ulcerans via toll-like receptors and dectin-1 in human keratinocytes
    Hye Mi Lee
    Department of Microbiology, Chungnam National University, Daejeon, South Korea
    Cell Microbiol 11:678-92. 2009
    ..Our results demonstrate that TLR2, TLR4 and Dectin-1 actively sense, internalize and respond in an innate way to MU in human epidermal keratinocytes...
  26. pmc Pattern recognition: recent insights from Dectin-1
    Delyth M Reid
    Institute of Medical Sciences, Foresterhill, University of Aberdeen, United Kingdom
    Curr Opin Immunol 21:30-7. 2009
    ..Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections...
  27. doi Dectin-1 is required for human dendritic cells to initiate immune response to Candida albicans through Syk activation
    Franck Skrzypek
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Microbes Infect 11:661-70. 2009
    ..albicans leading to T cells response alteration. These effects are largely, though not completely, mediated by Syk activation...
  28. doi Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients
    Theo S Plantinga
    Departments of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 49:724-32. 2009
    ....
  29. doi Dectin-1 is inducible and plays an essential role for mycobacteria-induced innate immune responses in airway epithelial cells
    Hye Mi Lee
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    J Clin Immunol 29:795-805. 2009
    ..The c-type lectin Dectin-1 is expressed predominantly on the surface of myeloid lineage cells. In this study, we examined the induction, regulation, and functions of Dectin-1 in pulmonary epithelial cells...
  30. pmc Human dectin-1 deficiency and mucocutaneous fungal infections
    Bart Ferwerda
    Department of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen, The Netherlands
    N Engl J Med 361:1760-7. 2009
    ....
  31. doi (1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages
    Päivi Kankkunen
    Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    J Immunol 184:6335-42. 2010
    ..In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively...
  32. doi Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity
    Cristina Cunha
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Blood 116:5394-402. 2010
    ..In this study, the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading to diminished Dectin-1 receptor activity was studied in relation to ..
  33. pmc The Y238X stop codon polymorphism in the human β-glucan receptor dectin-1 and susceptibility to invasive aspergillosis
    Louis Y A Chai
    Department of Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    J Infect Dis 203:736-43. 2011
    ..We investigated whether defective Dectin-1 receptor function, because of the early stop codon polymorphism Y238X, enhances susceptibility to invasive aspergillosis (IA) in at-risk patients...
  34. pmc Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 7:e1001259. 2011
    ..Thus, dectin-1 and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1-dependent activation of c-Rel...
  35. doi Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 13:246-54. 2012
    ..Thus, dectin-1 acted as an extracellular sensor for pathogens that induced both IL-1β production and maturation through a noncanonical caspase-8-dependent inflammasome for protective immunity...
  36. ncbi Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells
    W K Sun
    Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing 210002, China
    Eur J Clin Microbiol Infect Dis 31:2755-64. 2012
    ..Our results demonstrate the novel induction of Dectin-1 in human bronchial epithelial cells and its critical role in the innate immune response against A. fumigatus in non-phagocytic cells...
  37. ncbi Characterization of the human beta -glucan receptor and its alternatively spliced isoforms
    J A Willment
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 276:43818-23. 2001
    ..The human receptor also binds T-lymphocytes at a site distinct from the beta-glucan binding site, indicating that this receptor can recognize both endogenous and exogenous ligands...
  38. pmc Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
    David M Underhill
    Institute for Systems Biology, Seattle, WA 98103, USA
    Blood 106:2543-50. 2005
    ..The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential...
  39. ncbi Dectin-1: a signalling non-TLR pattern-recognition receptor
    Gordon D Brown
    Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa
    Nat Rev Immunol 6:33-43. 2006
    ....
  40. ncbi Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM
    Jianhui Xie
    State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, PR China
    Biochem Biophys Res Commun 347:1067-73. 2006
    ..The binding of hDectin-1E and RanBPM was further confirmed in vivo by co-immunoprecipitation assay and confocal microscopic analysis. Taken together, our data provide a clue to the understanding of the function about hDectin-1E...
  41. ncbi Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands
    J Immunol 178:154-62. 2007
    ..Taken together, these findings show that tetraspanin CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production...
  42. doi Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages
    Gerben Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Microbiol 10:2058-66. 2008
    ..Conclusively, dectin-1 synergizes with both TLR2 and TLR4 pathways for the production of TNF-alpha in human primary PBMCs and in monocyte-derived macrophages...
  43. pmc Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease
    Hilbert S de Vries
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e7818. 2009
    ..714T>G (p.Y238X) polymorphism is associated with lower disease susceptibility or severity in IBD and to investigate the level of dectin-1 expression in inflamed and non-inflamed colon tissue of IBD patients...
  44. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
    ..In this study, dectin-1 mRNA and protein expression, as well as the recently characterized DECTIN-1 Y238X early stop codon polymorphism, were studied in relation to rheumatoid arthritis (RA) susceptibility and severity...
  45. doi Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast
    Jr Shiuan Lin
    Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Leukoc Biol 88:95-106. 2010
    ..Our study delineated the distinct roles of CR3, Dectin-1, and sialic acids in the interaction with Histoplasma and suggested that multiple receptor use might be important to host defense against Histoplasma...
  46. doi The incidence of acute graft-versus-host disease increases with Candida colonization depending the dectin-1 gene status
    Walter J F M van der Velden
    Department of Hematology, Radboud University Nijmegen Medical Center, HB Nijmegen, The Netherlands
    Clin Immunol 136:302-6. 2010
    ..These are the first human data showing a role for Candida in the pathogenesis of acute GvHD. The mechanism could involve C-type lectin receptor mediated Th17 responses...
  47. doi A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis
    Heleen D de Koning
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 130:2611-20. 2010
    ..Only a few genes were differentially induced in psoriasis (CLEC7A (dectin-1), Toll-like receptor (TLR) 4, and mannose receptor C type 1 (MRC1)) or AD (MRC1, IL1RN, and IL1β) ..
  48. doi Regulation of dectin-1-mediated dendritic cell activation by peroxisome proliferator-activated receptor-gamma ligand troglitazone
    Grethe Kock
    Department of Hematology and Oncology, University of Bonn, Wilhelmstrasse 35 37, Bonn, Germany
    Blood 117:3569-74. 2011
    ..This confirms their important role as negative-feedback regulators of potentially harmful inflammatory responses...
  49. pmc The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
    Shih Chin Cheng
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Leukoc Biol 90:357-66. 2011
    ..These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans...
  50. ncbi Yeast-derived beta-(1-3),(1-6)-D-glucan induces up-regulation of CD86 on dectin-1-positive human B-lymphoma cell lines
    Ulf Harnack
    Medical Clinic of Oncology and Hematology, Charite University Medicine Berlin, Campus Mitte, 10117 Berlin, Germany
    Anticancer Res 31:4195-9. 2011
    ....
  51. pmc Antibody constant region peptides can display immunomodulatory activity through activation of the Dectin-1 signalling pathway
    Elena Gabrielli
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS ONE 7:e43972. 2012
    ..The findings suggest that some Fc-peptides, potentially deriving from the proteolysis of immunoglobulins, may cause an unexpected immunoregulation in a way reminiscent of innate immunity molecules...
  52. ncbi The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Immunol 172:1157-62. 2004
    ..These studies have identified SIGNR1 as a major MR for fungal and other pathogens present on specific subsets of Mphi...
  53. ncbi Mannose-containing molecular patterns are strong inducers of cyclooxygenase-2 expression and prostaglandin E2 production in human macrophages
    Nieves Fernández
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, Valladolid, Spain
    J Immunol 174:8154-62. 2005
    ....
  54. ncbi Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells
    P Hermanz-Falcón
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Immunogenetics 53:288-95. 2001
    We identified a new Ca2+-dependent lectin-like receptor gene, DECTIN-1 (HGMW-approved symbol CLECSF12), the human orthologue of mouse Dectin-1, coding for a putative type II transmembrane glycoprotein with an extracellular C-type lectin-..
  55. ncbi Molecular and functional characterization of human Dectin-1
    Frank Grunebach
    Department of Internal Medicine II, Division of Hematology, Immunology, and Oncology, University of Tubingen, Tubingen, Germany
    Exp Hematol 30:1309-15. 2002
    ..The aim of this study was to identify and characterize genes that are differentially expressed in DC generated from CD14+ peripheral blood monocytes in vitro...
  56. doi Dissimilar and similar functional properties of complement receptor-3 in microglia and macrophages in combating yeast pathogens by phagocytosis
    Smadar Hadas
    Department of Medical Neurobiology, IMRIC, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
    Glia 58:823-30. 2010
    ....
  57. ncbi Paxillin interactions
    C E Turner
    Dept of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY13210, USA
    J Cell Sci 113:4139-40. 2000
    ..Paxillin localizes to focal adhesions through its LIM domains, possibly through a direct association with &bgr;-integrin tails or an intermediate protein 'X'. In lymphoid cells it can bind directly to *(4)-integrin (not shown)...
  58. pmc Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers
    Riccardo A A Muzzarelli
    University of Ancona, Ancona, Italy
    Mar Drugs 8:292-312. 2010
    ....
  59. doi Cytoskeleton plays a dual role of activation and inhibition in myelin and zymosan phagocytosis by microglia
    Miri Gitik
    Department of Medical Neurobiology, Hebrew University Hadassah Medical School, P O B 12272, Jerusalem 91120, Israel
    FASEB J 24:2211-21. 2010
    ..Whether activation or inhibition occurs depends on the nature of the phagocytosed particle (C3bi-opsonized or nonopsonized myelin or zymosan) and the receptors mediating each phagocytosis...
  60. doi Investigation of beta-glucans binding to human/mouse dectin-1 and associated immunomodulatory effects on two monocyte/macrophage cell lines
    Mei Li Wu
    Dept of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan 912, ROC
    Biotechnol Prog 26:1391-9. 2010
    ..These results will likely contribute to further investigations on identifying the biological forms of β-glucans capable of binding its specific receptor as the effective immunomodulators...
  61. doi Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins
    Maryse Thivierge
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Immunol 183:6778-87. 2009
    ..This effect is partially dependent on an endogenous production of PGs and IL-10 by DCs...
  62. pmc The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophages
    C Astarie-Dequeker
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, UPR 9062, 31077 Toulouse, France
    Infect Immun 67:469-77. 1999
    ..In conclusion, MR-dependent phagocytosis is coupled neither to the activation of NADPH oxidase nor to the maturation of phagosomes until fusion with the Hck compartment and therefore constitutes a safe portal of entry for microorganisms...
  63. doi Expression of toll-like receptor 2, NOD2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytes
    M Kobayashi
    Department of Dermatology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Br J Dermatol 160:297-304. 2009
    ..Histamine, which is well known for itch and allergy, is closely associated with innate immunity, but its influence on epidermal innate immunity is still unclear...
  64. pmc Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1
    Rajinder P Parti
    Department of Pediatrics, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 42:415-23. 2010
    ..The results demonstrate that dectin-1 mediates the acute activation of cPLA(2)alpha in GM-CSF-primed alveolar macrophages, but not in the more delayed phase of AA release and GM-CSF-dependent prostanoid production...
  65. ncbi Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells
    Isela Valera
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, Universidad de Valladolid, Valladolid, Spain
    J Immunol 180:5727-36. 2008
    ..These findings help explain the distinct functional properties of DC matured by immune complexes vs those matured by beta-glucans...
  66. doi Dietary (1-->3), (1-->4)-beta-D-glucans from oat activate nuclear factor-kappaB in intestinal leukocytes and enterocytes from mice
    Julia J Volman
    Department of Human Biology, Maastricht University Medical Centre, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
    Nutr Res 30:40-8. 2010
    ....
  67. ncbi Does membrane fluidity contribute to thermal compensation of beta-adrenergic signal transduction in isolated trout hepatocytes?
    S J McKinley
    Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
    J Exp Biol 203:631-40. 2000
    The potential role of compensatory adjustments to membrane components in determining the function of the (&bgr;)-adrenergic receptor/adenylyl cyclase ((&bgr;)-AR/AC) signal-transduction system was studied in isolated hepatocytes ..
  68. pmc Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype
    Shikha Bhatia
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e15943. 2011
    ..Collectively, our studies suggest that alveolar macrophages, which predominantly acquire an AAM phenotype following A. fumigatus infection, have a protective role in defense against this fungus...
  69. ncbi Nerve growth factor stimulates coupling of beta1 integrin to distinct transport mechanisms in the filopodia of growth cones
    P W Grabham
    Department of Pharmacology and Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    J Cell Sci 113:3003-12. 2000
    ..NGF also greatly increased the steady rearward migration of beads coated with a high density of (&bgr;)1 integrin antibody, indicating that coupling of cross-linked receptor to the retrograde flow of actin is also ..
  70. ncbi [Strategy of Aspergillus fumigatus to evade attacks from host--projectile weapons and armor]
    Takahito Toyotome
    Division of Fungal Infection, Medical Mycology Research Center, Chiba University, Chiba, Japan
    Nihon Ishinkin Gakkai Zasshi 50:139-45. 2009
    ..These findings suggest that A. fumigatus evades the recognition and the attack from host by masking beta-glucan. A. fumigatus has clever mechanisms to defend itself and to attack the host immune system...
  71. pmc Characterization of beta-glucan recognition site on C-type lectin, dectin 1
    Yoshiyuki Adachi
    Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo, 192 0392, Japan
    Infect Immun 72:4159-71. 2004
    b>Dectin 1 is a mammalian cell surface receptor for (1-->3)-beta-d-glucans. Since (1-->3)-beta-d-glucans are commonly present on fungal cell walls, it has been suggested that dectin 1 is important for recognizing fungal invasion...
  72. ncbi The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1
    Margaret M Kelly
    Immunology Research Group, Department of Physiology, University of Calgary, Room 1863, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1 Canada
    Am J Respir Cell Mol Biol 38:227-38. 2008
    ..Depletion of alveolar macrophages did not affect the response to zymosan. Neither complement, macrophages, nor TLR2, TLR4, MyD88, and/or dectin-1 receptors were involved in the pulmonary in vivo inflammatory response to zymosan...
  73. doi Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching
    Elizabeth L Adams
    Department of Surgery, PO Box 70575, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 325:115-23. 2008
    ....
  74. doi Identification of the porcine C-type lectin dectin-1
    Eva Sonck
    Laboratory of Veterinary Immunology, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Immunol Immunopathol 130:131-4. 2009
    ..The transcript was not expressed in the liver, kidneys, the bladder, the heart, the brains and the skin...
  75. doi Dectin-1 and inflammation-associated gene transcription and expression in mouse lungs by a toxic (1,3)-beta-D glucan
    Thomas G Rand
    Department of Biology, Saint Mary s University, 923 Robie St, Halifax, NS B3H 3C3, Canada
    Arch Toxicol 84:205-20. 2010
    ..These observations also provide a biological basis for the irritant and inflammatory response to curdlan observed in humans and animals in experimental studies...
  76. ncbi Syndecan-4 core protein is sufficient for the assembly of focal adhesions and actin stress fibers
    F Echtermeyer
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Building 149, Charlestown, Massachusetts 02129, USA
    J Cell Sci 112:3433-41. 1999
    The formation of focal adhesions and actin stress fibers on fibronectin is dependent on signaling through (&bgr;)1 integrins and the heparan sulfate proteoglycan syndecan-4, and we have analyzed the requirement of the ..
  77. pmc TLR2 modulates inflammation in zymosan-induced arthritis in mice
    Matthias E Frasnelli
    Laboratoire de Rhumatologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Arthritis Res Ther 7:R370-9. 2005
    ..These results show that ZIA is more prolonged than was originally described and involves both the innate and acquired immune pathways. C3 does not seem to have a major role in this model of joint inflammation...
  78. doi Contribution of dectin-1 and granulocyte macrophage-colony stimulating factor (GM-CSF) to immunomodulating actions of beta-glucan
    Toshie Harada
    Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Int Immunopharmacol 8:556-66. 2008
    ..In this review, we describe how the key molecules related to the expression of the immunomodulating activities of beta-glucan were identified, and how the response to beta-glucan is controlled...
  79. pmc Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes
    Subha Karumuthil-Melethil
    Department of Surgery, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 181:8323-34. 2008
    ..Here we report the effect of ligation of TLR2 and dectin 1 on APCs and the influence of innate immune response induced through these receptors on T1D...
  80. doi Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection
    Carlos Artério Sorgi
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    J Immunol 182:4025-35. 2009
    ..These results demonstrate that Hc induces LB formation, an event correlated with eicosanoid production, and suggest a role for these lipid-enriched organelles in host defense during fungal infection...
  81. doi Galectins in innate immunity: dual functions of host soluble beta-galactoside-binding lectins as damage-associated molecular patterns (DAMPs) and as receptors for pathogen-associated molecular patterns (PAMPs)
    Sachiko Sato
    Glycobiology Laboratory, Research Centre for Infectious Diseases, Faculty of Medicine, Laval University, QC, Canada
    Immunol Rev 230:172-87. 2009
    ....
  82. pmc Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1
    Suganya Viriyakosol
    Veterans Affairs San Diego Healthcare System 111F, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    Infect Immun 73:1553-60. 2005
    ..Taken together, these results show that cytokine responses in mouse peritoneal macrophages to C. posadasii spherules are dependent on TLR2, MyD88, and Dectin-1...
  83. pmc Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages
    Simon Yona
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, EC1 M 6BQ
    Br J Pharmacol 142:890-8. 2004
    ..In conclusion, these results suggest that participation of endogenous annexin 1 during zymosan phagocytosis is critical and that this protein plays a tonic inhibitory role during macrophage activation...
  84. pmc Chitin, chitinases and chitinase-like proteins in allergic inflammation and tissue remodeling
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, Cedar Street, New Haven, CT 06520 8057, USA
    Yonsei Med J 50:22-30. 2009
    ..In this review, recent findings on the role of chitin and C/CLP in allergic inflammation and tissue remodeling will be highlighted and controversial and unsolved issues in this field of studies will be discussed...
  85. pmc Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages
    Erin K Kelly
    Graduate Program in Cell Biology and Genetics, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA
    J Immunol 184:5545-52. 2010
    ..These observations identify a new calcium-mediated signaling pathway activated by zymosan and link this pathway to both inflammatory and anti-inflammatory responses in macrophages...
  86. ncbi In vitro immunoregulatory effects of Korean mistletoe lectin on functional activation of monocytic and macrophage-like cells
    Ji Yeon Lee
    School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea
    Biol Pharm Bull 30:2043-51. 2007
    ....
  87. doi Binding capacity of a barley beta-D-glucan to the beta-glucan recognition molecule dectin-1
    Rui Tada
    Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan
    J Agric Food Chem 56:1442-50. 2008
    ....
  88. doi Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease
    Edward D Chan
    Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 43:387-93. 2010
    ..However, much remains to be discovered on why seemingly healthy individuals, particularly slender postmenopausal women with thoracic cage anomalies, appear to be at increased risk...
  89. pmc Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins
    Tsui Ling Hsu
    The Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 284:34479-89. 2009
    ..It also provides a means to dissect the molecular mechanism of medicinal polysaccharide-induced immunomodulation events...
  90. pmc C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi
    Marein A W P de Jong
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Immunol 47:1216-25. 2010
    ..Together these data may provide more insight in the role of LCs in fungal infections...
  91. ncbi Oral beta-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary tumor-bearing mice
    Jarek Baran
    Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville, KY, USA
    Folia Histochem Cytobiol 45:107-14. 2007
    ..The switch from a Th2 to a Th1 response after WGP therapy was possibly mediated by intestinal mucosal macrophages releasing IL-12...
  92. pmc Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists
    Haibin Huang
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, LRB317, Worcester, MA 01605, USA
    Infect Immun 77:1774-81. 2009
    ..These patterns of response might contribute to the skewing of immune responses during mycotic infections and have implications for the design of immunomodulators and vaccines containing beta-glucans...
  93. ncbi Effects of beta-glucans on the immune system
    Dalia Akramiene
    Department of Physiology, Kaunas University of Medicine, Kaunas, Lithuania
    Medicina (Kaunas) 43:597-606. 2007
    ..This mechanism could be induced in the presence of beta-glucans...
  94. pmc The effects of beta-glucan on human immune and cancer cells
    Godfrey Chi Fung Chan
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Hematol Oncol 2:25. 2009
    ..Future effort should direct at performing well-designed clinical trials to verify the actual clinical efficacy of beta-glucans or beta-glucans containing compounds...
  95. ncbi Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye
    G H Thomas
    Departments of Biology and of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Development 125:2125-34. 1998
    ..We have isolated mutations in the gene encoding &bgr ;Heavy-spectrin in Drosophila, and have named this essential locus karst...
  96. pmc A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
    Hiroyuki Yoshitomi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    J Exp Med 201:949-60. 2005
    ....
  97. doi Immunomodulatory effects of beta-glucans on porcine alveolar macrophages and bone marrow haematopoietic cell-derived dendritic cells
    Hso Chi Chaung
    Department of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, Taiwan, ROC
    Vet Immunol Immunopathol 131:147-57. 2009
    ..These results indicate that the complex collaborating interactions between dectin-1 and TLRs in the recognition of beta-1,3/beta-1,6-glucans with different structural features may direct different cellular responses...
  98. pmc Activated dectin-1 localizes to lipid raft microdomains for signaling and activation of phagocytosis and cytokine production in dendritic cells
    Shengli Xu
    Laboratory of Immunology, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668
    J Biol Chem 284:22005-11. 2009
    ....
  99. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010
    ..In contrast to Dectin 1(-/-) mice, cellular infiltration into infected TLR2(-/-), TLR4(-/-), and MD-2(-/-) mice corneas was unimpaired, ..
  100. ncbi The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signalling pathway
    Masako Mae
    Laboratory of Oral Molecular Microbiology, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Kita, Sapporo, Japan
    FEMS Immunol Med Microbiol 49:398-409. 2007
    ....
  101. ncbi Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2
    Alde Carlo P Gavino
    Department of Dermatology, The University of Texas South Western Medical Center and Dermatology Section Medical Service, Dallas Veterans Affairs Medical Center, Dallas, TX 75390 9069, USA
    Exp Dermatol 14:281-8. 2005
    ..Our findings may form the basis for understanding the function of human DECTIN-2 in innate immunity...

Research Grants49

  1. David M Underhill; Fiscal Year: 2016
    ..In Aim 3 we will define the effect of the role of Dectin-1 and NFAT signaling in innate and adaptive immune responses in vivo. ..
  2. The Role of Genetic Variation in the Fungal/Host Interaction
    Gerald R Fink; Fiscal Year: 2012
    ..The availability of sortagged Dectin-1 mice will provide a unique opportunity to identify new targets for anti-fungal agents. ..
  3. Dectin-1 and Immunity Against Pneumocystis Carinii
    Chad Steele; Fiscal Year: 2009
    ..carinii and may provide new insight into how P. carinii is recognized by the immune system, which may lead to novel immunotherapeutic strategies to combat this devastating pulmonary infection. ..
  4. Epithelial Regulation of Th2 Immune Responses in the Lung
    Marsha Wills-Karp; Fiscal Year: 2013
    ..List all other key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Wills-Karp, Marsha Wildc7 CCHMC PI Finkelman, Fred frefin CCHMC Co-Investigator ..
  5. Jatin M Vyas; Fiscal Year: 2016
    ..The fungal [unreadable]-1,3 glucan receptor Dectin1 is essential in pulmonary defense against A...
  6. Mechanisms of Immune Modulation Mediated by Yeast-derived Particulate Beta-Glucan
    Jun Yan; Fiscal Year: 2012
    ..The data generated in this study will allow for the rational design of immunotherapeutic protocols usable in clinical trials. ..
  7. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
    ..Therefore, we hypothesize that optimal IL-17-mediated defense against A. fumigatus is dependent on the beta glucan receptor Dectin-1...
  8. Enhancing TB vaccine with gene silencing
    Jinhee Lee; Fiscal Year: 2013
    ....
  9. Non-CD4 Host defense against P. carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2013
    ..3. Test the hypothesis that the combination of anti-Kex1 and anti-carbohydrate antibodies can mediate primary prophylaxis or treatment of PCP in T-cell deficient mice. ..
  10. Host response to P. carinii in neonatal mice
    Beth A Garvy; Fiscal Year: 2013
    ..These studies are a logical extension of our previous funding period and will address the mechanisms responsible for neonatal unresponsiveness Pneumocystis. ..
  11. STUART MICHAEL LEVITZ; Fiscal Year: 2016
    ..As broad concepts are being studied, the knowledge gained should also be applicable to the development of vaccines against other infectious diseases. ..
  12. Michael B Brenner; Fiscal Year: 2015
    ..Here, we will determine what activates them and how they play a critical role in control of important fungal infections. ..
  13. David M Underhill; Fiscal Year: 2015
    ..In aim 4 we will determine whether Dectin-1 and CARD9 knockout mice also exhibit enhanced susceptibility to spontaneous disease and disease induced by T cell transfer. ..
  14. Human polymorphic variance in the Dectin-1 signaling pathway
    ANDREA JEAN WOLF; Fiscal Year: 2010
    ..We have discovered significant genetic variability between humans in the genes for these two proteins. In this project we will fully characterize the effects of these genetic variants on the molecular mechanisms of signaling. ..
  15. Controlling Allergen-specific Th2-type Responses by Targeting DC Surface Lectins
    SangKon Oh; Fiscal Year: 2013
    ....
  16. Dectin-1 and Invasive Pulmonary Aspergillosis
    Chad Steele; Fiscal Year: 2010
    ..fumigatus. Therefore, our central hypothesis is that the Dectin-1 beta glucan receptor is required for immunity against A...
  17. Host Factors in Fungal Allergy and Fibrosis
    Anuradha Ray; Fiscal Year: 2010
    ..The long-term objective of the SCCOR is to use the knowledge of the molecular pathways to improve diagnosis and treatment of patients suffering form chronic lung diseases particularly allergic and fibrotic lung diseases. ..
  18. Effects of Microbial Exposure on Myelopoiesis
    HELEN SARA GOODRIDGE; Fiscal Year: 2011
    ..We are defining how these cells are generated during infection, and how infection affects their function. Clinical manipulation of these cells may improve our ability to fight infection or prevent the damaging effects of inflammation. ..
  19. Regulation of immune reactions by synthetic thioglucans
    Vaclav Vetvicka; Fiscal Year: 2010
    ..Based on our preliminary data, we hypothesize that these oligosaccharides will be more active and will overcome intrinsic problems with natural b-glucans that make them undesirable as drugs. ..
  20. Tricia D LeVan; Fiscal Year: 2014
    ..We anticipate that this project could advance us towards the development of pharmacogenetic-based treatments for COPD and address the VA initiative towards genomic medicine. ) ) ..
  21. CD1d and NKT Cell Activation and Function in Infection
    Michael B Brenner; Fiscal Year: 2010
    ..abstract_text> ..
  22. STUART MICHAEL LEVITZ; Fiscal Year: 2016
    ..In addition, the studies should establish a proof of principle regarding the efficacy of GP-based vaccine platforms that should be applicable to other vaccine-preventable diseases and form the basis for eventual testing in humans. ..
  23. B DERMATITIDIS CONIDIAL-MACROPHAGE INTERACTIONS
    Stephen Moser; Fiscal Year: 1993
    ..The results of proposed studies will provide the basis for future molecular and genetic investigations of this important group of human fungal pathogens...
  24. Determinants of antibody-based host resistance against Pneumocystis carinii
    REKHA RAPAKA; Fiscal Year: 2009
    ....
  25. Alveolar macrophage NF-kB signaling in HIV
    Jianmin Zhang; Fiscal Year: 2004
    ..abstract_text> ..
  26. BIOLOGY OF THE THY-1 ANTIGEN BEARING EPIDERMAL CELLS
    Akira Takashima; Fiscal Year: 2002
    ..Through these five specific aims they intend to uncover unique activities of IL-13 in the skin. ..
  27. BETA-GLUCAN RECEPTOR
    Jonathan Reichner; Fiscal Year: 1999
    ..These studies will test the hypothesis that the non-opsonic beta-glucan receptor plays a greater role in host defense under conditions of compromised opsonin-dependent phagocytosis. ..
  28. Genetic Factors Controlling Effector Function of TGF-beta in COPD and Fibrosis
    Chun Geun Lee; Fiscal Year: 2011
    ..AIM #4. Define the genes that determine whether TGF-b1 induceds a predominantly fibrotic versus emphysematous response in C57BL/6 and Balb/c mice. ..
  29. Enhancing axon regeneration by multi-inhibitor blocking
    RONALD SCHNAAR; Fiscal Year: 2005
    ..The resulting data may provide insight on the relative contributions of the different ARI's in an in vivo model, and may support evaluation of new approaches to enhance axon regeneration after CNS injury. ..
  30. An ATP receptor-operated ionic conductance in Paramecium
    Todd Hennessey; Fiscal Year: 2002
    ....
  31. COMPLEX CARBOHYDRATES IN NEURONAL CELL FUNCTION
    RONALD SCHNAAR; Fiscal Year: 2004
    ....
  32. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  33. Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    Yury Miller; Fiscal Year: 2010
    ..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
  34. BETA H-SPECTRIN--ROLES IN CELL POLARITY AND SIGNALING
    Graham Thomas; Fiscal Year: 2001
    ..They will also illuminate the relationship between ras signaling and the cytoskeleton, a relationship that is important for oncogenic and metastatic processes. ..
  35. Model Vaccines Exploiting Fungal Mannosylation
    STUART LEVITZ; Fiscal Year: 2009
    ....
  36. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2004
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
  37. SYNDECAN-4 SIGNALING IN CELL-MATRIX INTERACTIONS
    Paul Goetinck; Fiscal Year: 2008
    ..The information gained from the proposed studies, therefore, is directly applicable to the understanding of uncontrolled growth as in cancer and controlled growth as in wound healing. ..
  38. Macrophage signaling upon M avium infection
    Jeffrey Schorey; Fiscal Year: 2008
    ..avium pathogenesis and in macrophage activation. We will use a combination of genetic, immunological and cell biological approaches to address these important questions. ..
  39. TOLL-LIKE RECEPTORS: ACTIVATORS OF INNATE IMMUNITY
    David Underhill; Fiscal Year: 2005
    ....
  40. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2009
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  41. Aspergillus Angioinvasion and Dissemination
    Scott Filler; Fiscal Year: 2006
    ..These studies are designed to lay the essential foundation for a comprehensive research program aimed at elucidating the molecular mechanisms by which A. fumigatus invades blood vessels and hematogenously disseminates. ..
  42. Dendritic cell mediated modulation of tolerance by apoptotic cells in aging
    Anshu Agrawal; Fiscal Year: 2007
    ..2) to analyze a role of dendritic cells in age-associated alterations in the induction and maintenance of peripheral tolerance. [unreadable] [unreadable] [unreadable]..
  43. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  44. HISTONE ACETYLTRANSFERASE AND TRANSCRIPTIONAL REGULATION
    Min Hao Kuo; Fiscal Year: 2005
    ..Moreover, individual roles played by the ADA and SAGA complexes in HIS3 expression are to be investigated both genetically and biochemically. ..
  45. MACROPHAGE INTERACTIONS WITH C. NEOFORMANS
    STUART LEVITZ; Fiscal Year: 2005
    ..Completion of these aims will add significantly to our understanding of the immunopathogenesis of cryptococcosis and may suggest novel approaches to the prevention and treatment of this life-threatening mycosis. ..
  46. 6th International Conf. on Cryptococcus & Cryptococcosis
    STUART LEVITZ; Fiscal Year: 2005
    ..neoformans and Cryptococcosis and to recommend new and future research initiatives and prioritize these. ..
  47. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2005
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  48. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2007
    ..Thus it is critical to identify and study all the genetic players in this process. ..
  49. CYTOTOXIC T LYMPHOCYTE RESPONSE TO HPV 16
    Mayumi Nakagawa; Fiscal Year: 2002
    ....

Patents1

  1. Macrophage receptor agonist or antagonist
    Patent Number: WO02096945-A2; Date:2002-12-05