COX5A

Summary

Gene Symbol: COX5A
Description: cytochrome c oxidase subunit 5A
Alias: COX, COX-VA, cytochrome c oxidase subunit 5A, mitochondrial, cytochrome c oxidase polypeptide Va, cytochrome c oxidase polypeptide, mitochondrial, cytochrome c oxidase subunit Va, mitochondrial cytochrome c oxidase subunit Va
Species: human
Products:     COX5A

Top Publications

  1. Chen Z, Pervaiz S. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ. 2010;17:408-20 pubmed publisher
    ..In this study, we show that Bcl-2 expression positively influences the targeting of nuclear-encoded COX Va and Vb to the mitochondria of cancer cells...
  2. Rizzuto R, Nakase H, Zeviani M, DiMauro S, Schon E. Subunit Va of human and bovine cytochrome c oxidase is highly conserved. Gene. 1988;69:245-56 pubmed
    ..clone specifying the nuclear-encoded subunit Va of the human mitochondrial respiratory enzyme cytochrome c oxidase (COX; EC 1.9.3.1.)...
  3. Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H, Zeman J. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. Biochem J. 2010;428:363-74 pubmed publisher
    ..CcO subunits in the assembly and function of the human complex, we used stable RNA interference of COX4, COX5A and COX6A1, as well as expression of epitope-tagged Cox6a, Cox7a and Cox7b, in HEK (human embryonic kidney)-293 ..
  4. Li G, Xia M, Abais J, Boini K, Li P, Ritter J. Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes. J Pharmacol Exp Ther. 2016;358:61-70 pubmed publisher
    ..These effects of AEA were inhibited by the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CEL)...
  5. Lu J, Shao R, Jin S, Hu L, Tu Y, Guo J. Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression. Brain Res Bull. 2017;128:106-112 pubmed publisher
    ..NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa B (NF-κB) were determined in the rat hippocampus and prefrontal cortex...
  6. Fusar Poli P, Palombini E, Davies C, Oliver D, Bonoldi I, Ramella Cravaro V, et al. Why transition risk to psychosis is not declining at the OASIS ultra high risk service: The hidden role of stable pretest risk enrichment. Schizophr Res. 2017;: pubmed publisher
    ..of psychosis were stratified and compared across three time periods (2001-2005, 2006-2010, 2011-2015) with Cox analysis and modulating factors were investigated...
  7. Sohilait M, Pranowo H, Haryadi W. Molecular docking analysis of curcumin analogues with COX-2. Bioinformation. 2017;13:356-359 pubmed publisher
    Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully...
  8. Mohd Aluwi M, Rullah K, Yamin B, Leong S, Abdul Bahari M, Lim S, et al. Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines. Bioorg Med Chem Lett. 2016;26:2531-8 pubmed publisher
    ..Further experiment showed that compounds 8b, 8c, 15a and 15b did not target the activity of downstream inflammatory COX-2 mediator...
  9. Iaboni A, Rawson K, Burkett C, Lenze E, Flint A. Potentially Inappropriate Medications and the Time to Full Functional Recovery After Hip Fracture. Drugs Aging. 2017;34:723-728 pubmed publisher
    ..b>Cox proportional hazards models examined the time to 95% recovery of function ('full recovery'), adjusting for ..
  10. Park E, Lee M, Seo C, Jeon W, Shin H. Yongdamsagan-tang, a traditional herbal formula, inhibits cell growth through the suppression of proliferation and inflammation in benign prostatic hyperplasia epithelial-1 cells. J Ethnopharmacol. 2017;209:230-235 pubmed publisher
    ..Furthermore, YSTE treatment in BPH-1 cells suppressed prostaglandin E2 production and cyclooxygenase-2 (COX-2) protein levels...

Detail Information

Publications62

  1. Chen Z, Pervaiz S. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ. 2010;17:408-20 pubmed publisher
    ..In this study, we show that Bcl-2 expression positively influences the targeting of nuclear-encoded COX Va and Vb to the mitochondria of cancer cells...
  2. Rizzuto R, Nakase H, Zeviani M, DiMauro S, Schon E. Subunit Va of human and bovine cytochrome c oxidase is highly conserved. Gene. 1988;69:245-56 pubmed
    ..clone specifying the nuclear-encoded subunit Va of the human mitochondrial respiratory enzyme cytochrome c oxidase (COX; EC 1.9.3.1.)...
  3. Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H, Zeman J. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. Biochem J. 2010;428:363-74 pubmed publisher
    ..CcO subunits in the assembly and function of the human complex, we used stable RNA interference of COX4, COX5A and COX6A1, as well as expression of epitope-tagged Cox6a, Cox7a and Cox7b, in HEK (human embryonic kidney)-293 ..
  4. Li G, Xia M, Abais J, Boini K, Li P, Ritter J. Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes. J Pharmacol Exp Ther. 2016;358:61-70 pubmed publisher
    ..These effects of AEA were inhibited by the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CEL)...
  5. Lu J, Shao R, Jin S, Hu L, Tu Y, Guo J. Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression. Brain Res Bull. 2017;128:106-112 pubmed publisher
    ..NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa B (NF-κB) were determined in the rat hippocampus and prefrontal cortex...
  6. Fusar Poli P, Palombini E, Davies C, Oliver D, Bonoldi I, Ramella Cravaro V, et al. Why transition risk to psychosis is not declining at the OASIS ultra high risk service: The hidden role of stable pretest risk enrichment. Schizophr Res. 2017;: pubmed publisher
    ..of psychosis were stratified and compared across three time periods (2001-2005, 2006-2010, 2011-2015) with Cox analysis and modulating factors were investigated...
  7. Sohilait M, Pranowo H, Haryadi W. Molecular docking analysis of curcumin analogues with COX-2. Bioinformation. 2017;13:356-359 pubmed publisher
    Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully...
  8. Mohd Aluwi M, Rullah K, Yamin B, Leong S, Abdul Bahari M, Lim S, et al. Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines. Bioorg Med Chem Lett. 2016;26:2531-8 pubmed publisher
    ..Further experiment showed that compounds 8b, 8c, 15a and 15b did not target the activity of downstream inflammatory COX-2 mediator...
  9. Iaboni A, Rawson K, Burkett C, Lenze E, Flint A. Potentially Inappropriate Medications and the Time to Full Functional Recovery After Hip Fracture. Drugs Aging. 2017;34:723-728 pubmed publisher
    ..b>Cox proportional hazards models examined the time to 95% recovery of function ('full recovery'), adjusting for ..
  10. Park E, Lee M, Seo C, Jeon W, Shin H. Yongdamsagan-tang, a traditional herbal formula, inhibits cell growth through the suppression of proliferation and inflammation in benign prostatic hyperplasia epithelial-1 cells. J Ethnopharmacol. 2017;209:230-235 pubmed publisher
    ..Furthermore, YSTE treatment in BPH-1 cells suppressed prostaglandin E2 production and cyclooxygenase-2 (COX-2) protein levels...
  11. Gul I, Yucel O, Zararsiz A, Demirpence O, Yucel H, Zorlu A, et al. Prognostic role of soluble suppression of tumorigenicity-2 on cardiovascular mortality in outpatients with heart failure. Anatol J Cardiol. 2017;18:200-205 pubmed publisher
    ..In multiple Cox regression analysis, sST2 level of >30 ng/mL (HR=6.756, p=0.002, 95% CI=1.983-23.018), hemoglobin level (HR=0...
  12. Anvari M, Joyner Melito H. Effect of fish gelatin-gum arabic interactions on structural and functional properties of concentrated emulsions. Food Res Int. 2017;102:1-7 pubmed publisher
    ..moduli under small deformation and exhibited greater deviation between apparent and complex viscosities under the Cox-Merz rule, indicating increased gel network extension and greater intermolecular connectivity between adsorbed ..
  13. Jeng W, Chen Y, Chien R, Sheen I, Liaw Y. Incidence and predictors of HBsAg seroclearance after cessation of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B. Hepatology. 2017;: pubmed publisher
    ..The 6-year cumulative incidence was 13% with an estimated annual incidence of 1.78%. Cox regression analysis showed that shorter time to undetectable HBV DNA (<12wks), greater HBsAg reduction during ..
  14. Cole S, Edwards J, Westreich D, Lesko C, Lau B, Mugavero M, et al. Estimating multiple time-fixed treatment effects using a semi-Bayes semiparametric marginal structural Cox proportional hazards regression model. Biom J. 2017;: pubmed publisher
    ..We illustrate the approach with data from a nonexperimental study of HIV treatments...
  15. Joo E, Yeom J, Kwon M, Chang Y, Ryu S. Insulin resistance increases loss of antibody to hepatitis B surface antigen in nondiabetic healthy adults. J Viral Hepat. 2016;23:889-896 pubmed publisher
    ..A decline in anti-HBs to <10 mIU/L during the follow-up was considered to be a loss of protective anti-HBs. Cox-proportional hazard models were used to estimate the adjusted hazard ratios and 95% confidence intervals for anti-..
  16. Vetterlein M, Seisen T, Leow J, Preston M, Sun M, Friedlander D, et al. Effect of Nonurothelial Histologic Variants on the Outcomes of Radical Cystectomy for Nonmetastatic Muscle-invasive Urinary Bladder Cancer. Clin Genitourin Cancer. 2017;: pubmed publisher
    ..Inverse probability weighting-adjusted and facility-clustered Cox and logistic regression analyses were used to assess the effect of histologic variants versus PUC on OS and ..
  17. Wijma R, Perez M, Masello M, Stangaferro M, Giordano J. A resynchronization of ovulation program based on ovarian structures present at nonpregnancy diagnosis reduced time to pregnancy in lactating dairy cows. J Dairy Sci. 2018;101:1697-1707 pubmed publisher
    ..Binomial outcomes were analyzed with logistic regression and hazard of pregnancy (R32 = 485; SR = 462) with Cox's proportional regression in SAS (SAS Institute, Cary, NC)...
  18. Liu Y, Ju M, Pan S, He H, Luo Z, Gu Z. [Relationship between blood lactate level and the prognosis of patients with diabetic sepsis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:689-693 pubmed publisher
    ..by Kaplan-Meier regression analysis, and the factors influencing the prognosis were analyzed by multivariate Cox regression analysis. There were 76 males and 30 females sepsis patients, with an average age of (68.1±14...
  19. Dinerman B, Khani F, Golan R, Bernstein A, Cosiano M, Margolis D, et al. Population-based study of the incidence and survival for intraductal carcinoma of the prostate. Urol Oncol. 2017;35:673.e9-673.e14 pubmed publisher
    ..The effect of IDC-P on overall and disease-specific survival was assessed using Cox regression with a median follow-up of 4.8 years (interquartile range [IQR]: 2.6-7.0y; P = 0.01)...
  20. Zhuo C, Ying M, Lin R, Wu X, Guan S, Yang C. Negative lymph node count is a significant prognostic factor in patient with stage IV gastric cancer after palliative gastrectomy. Oncotarget. 2017;8:71197-71205 pubmed publisher
    ..Kaplan-Meier survival curves and multivariate Cox proportional hazards model were used to assess the risk factors for patients' survivals...
  21. Anzoise M, Basso A, Del Mauro J, Carranza A, Ordieres G, Gorzalczany S. Potential usefulness of methyl gallate in the treatment of experimental colitis. Inflammopharmacology. 2017;: pubmed publisher
    ..Furthermore, the administration of methyl gallate reduced the expression of COX2, IL-6, TNFα and the severity of microscopic tissue damage induced by acetic acid, while the mean ..
  22. Odimegwu C, De Wet N, Somefun O. Perceptions of social capital and sexual behaviour among youth in South Africa. J Child Adolesc Ment Health. 2017;:1-13 pubmed publisher
    ..The Cox proportional hazards regression model was used to predict the risk for early sexual debut...
  23. Jia T, Qiao J, Guan D, Chen T. Anti-Inflammatory Effects of Licochalcone A on IL-1β-Stimulated Human Osteoarthritis Chondrocytes. Inflammation. 2017;40:1894-1902 pubmed publisher
    ..IL-1β-induced iNOS and COX-2 expression were also inhibited by Lico A...
  24. Tian M, Zhu L, Lin H, Lin Q, Huang P, Yu X, et al. Hsp-27 levels and thrombus burden relate to clinical outcomes in patients with ST-segment elevation myocardial infarction. Oncotarget. 2017;8:73733-73744 pubmed publisher
    ..847; 95% CI, 0.775-0.918; P < 0.01). The multivariate cox regression analysis demonstrated that Hsp-27 > 45 ng/mL (HR 2.801, 95% CI 1.296-4.789, P = 0...
  25. Sun L, Subar A, Bosire C, Dawsey S, Kahle L, Zimmerman T, et al. Dietary Flavonoid Intake Reduces the Risk of Head and Neck but Not Esophageal or Gastric Cancer in US Men and Women. J Nutr. 2017;147:1729-1738 pubmed publisher
    ..We used Cox proportional hazards regression models to estimate HRs and CIs for the associations between flavonoid intake ..
  26. Lin C, Li C, Liu C, Lin W, Lin C, Yang S, et al. Development and validation of a risk prediction model for end-stage renal disease in patients with type 2 diabetes. Sci Rep. 2017;7:10177 pubmed publisher
    ..Participants were randomly assigned to the derivation and validation sets at a 2:1 ratio. The Cox proportional hazard regression model was used for model development. A total of 813 and 402 subjects (5.06% and 5...
  27. McCoy M, Geppert J, Dech L, Richardson M. Associations Between Peer Counseling and Breastfeeding Initiation and Duration: An Analysis of Minnesota Participants in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Matern Child Health J. 2018;22:71-81 pubmed publisher
    ..Multivariate logistic regression and Cox regression models examined associations between peer services and breastfeeding initiation and continuation of any ..
  28. Shen Tu Y, Mao F, Pan Y, Wang W, Zhang L, Zhang H, et al. Lymph node dissection and survival in patients with early stage nonsmall cell lung cancer: A 10-year cohort study. Medicine (Baltimore). 2017;96:e8356 pubmed publisher
    ..The association between lymph node dissection and the survival of NSCLC patients was assessed using Cox proportional-hazard models.Patients in the MLND group presented better survival (median survival time = 154...
  29. Jung T, Jung M, Cacciola S, Cech T, Bakonyi J, Seress D, et al. Multiple new cryptic pathogenic Phytophthora species from Fagaceae forests in Austria, Italy and Portugal. IMA Fungus. 2017;8:219-244 pubmed publisher
    ..Multigene phylogeny based on nuclear ITS, ß-tubulin and HSP90 and mitochondrial cox1 and NADH1 gene sequences demonstrated that two species, P. tyrrhenica and P. vulcanica spp. nov...
  30. Ao M, Feng Y, Xiao G, Xu Y, Hong J. Clinical outcome of Descemet stripping automated endothelial keratoplasty in 18 cases with iridocorneal endothelial syndrome. Eye (Lond). 2017;: pubmed publisher
    ..A Log-rank test in a Kaplan-Meier analysis and a Cox proportional hazard regression were used to analyse potential risk factors of graft failure...
  31. Tobias J. Weak analgesics and nonsteroidal anti-inflammatory agents in the management of children with acute pain. Pediatr Clin North Am. 2000;47:527-43 pubmed
    ..functioning, RBF, and the GI tract may be eliminated with the introduction of NSAIDs that selectively inhibit COX II without effects on COX I, the enzyme present in the GI tract, renal system, and platelets...
  32. Aguirre Martínez G, Andre C, Gagne F, Martín Díaz L. The effects of human drugs in Corbicula fluminea. Assessment of neurotoxicity, inflammation, gametogenic activity, and energy status. Ecotoxicol Environ Saf. 2018;148:652-663 pubmed publisher
    ..exposure period, dopamine levels (DOP), monoamine oxidase activity (MAO), arachidonic acid cyclooxygenase activity (COX), vitellogenin-like proteins (VTG), mitochondrial electron transport (MET), total lipids (TLP), and energy ..
  33. Seyedin S, Mitchell D, Mott S, Russo J, Tracy C, Snow A, et al. Is More Always Better? An Assessment of the Impact of Lymph Node Yield on Outcome for Clinically Localized Prostate Cancer with Low/Intermediate Risk Pathology (pT2-3a/pN0) Managed with Prostatectomy Alone. Pathol Oncol Res. 2017;: pubmed publisher
    ..Kaplan-Meier method was employed for survival probability estimation. Cox regression models were used to assess bRFS differences between subsets...
  34. Frisk G, Tinge B, Ekberg S, Eloranta S, Bäcklund L, Lidbrink E, et al. Survival and level of care among breast cancer patients with brain metastases treated with whole brain radiotherapy. Breast Cancer Res Treat. 2017;166:887-896 pubmed publisher
    ..Survival was estimated using Cox regression, and odds ratios (OR) of not coming home using logistic regression...
  35. Bonnesen T, Winther J, Andersen K, Asdahl P, de Fine Licht S, Gudmundsdottir T, et al. Liver diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS): A population-based cohort study of 32,839 one-year survivors. Int J Cancer. 2017;: pubmed publisher
    ..We included all 1-year survivors of childhood cancer treated in the five Nordic countries. A Cox proportional hazards model was used to estimate hospitalisation rate (hazard) ratios (HRs) for each liver outcome ..
  36. Kornfield S, Kang Yi C, Mandell D, Epperson C. Predictors and Patterns of Psychiatric Treatment Dropout During Pregnancy Among Low-Income Women. Matern Child Health J. 2017;: pubmed publisher
    ..Kaplan-Meier and Cox regression analyses were used to estimate psychiatric treatment dropout rate during pregnancy and examine ..
  37. Xu C, Zhao J, Loo W, Hao L, Wang M, Cheung M, et al. Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis. Int J Biol Markers. 2012;27:e314-21 pubmed publisher
    ..The hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic levels...
  38. Morgia G, Voce S, Palmieri F, Gentile M, Iapicca G, Giannantoni A, et al. Association between selenium and lycopene supplementation and incidence of prostate cancer: Results from the post-hoc analysis of the procomb trial. Phytomedicine. 2017;34:1-5 pubmed publisher
    ..The relative risk (RR) for PCa was 1.07 and 0.89 in group A and B, respectively (p = 0.95). At the multivariate Cox regression analysis supplementation with Se and Ly was not associated with greater risk of PCa (hazard ratio: 1...
  39. YASHIN A, Fang F, Kovtun M, Wu D, Duan M, Arbeev K, et al. Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses. Exp Gerontol. 2017;: pubmed publisher
    ..The logistic regression and Cox's regression were used as statistical models in GWAS...
  40. Maliniak M, Patel A, McCullough M, Campbell P, Leach C, Gapstur S, et al. Obesity, physical activity, and breast cancer survival among older breast cancer survivors in the Cancer Prevention Study-II Nutrition Cohort. Breast Cancer Res Treat. 2017;: pubmed publisher
    ..Multivariable Cox proportional hazards regression models were used to examine associations of pre- and post-diagnosis body mass index ..
  41. Che D, Zhang S, Jing Z, Shang L, Jin S, Liu F, et al. Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/β-catenin signalling pathway. Mol Immunol. 2017;90:197-210 pubmed publisher
    ..In this study, the macrophage density and cyclooxygenase-2 (COX-2) protein were examined in surgical specimens by immunohistochemistry (IHC), and the prostaglandin E2 (..
  42. Wang G, Xu W, Li F, Su K, Li N, Lu Z, et al. [Relationship between inflammatory markers and the risk of colorectal cancer in Kailuan male cohort]. Zhonghua Yi Xue Za Zhi. 2017;97:3158-3161 pubmed publisher
    ..Multivariable Cox proportional hazards regression models were used to calculate hazard ratios (HR) of association between ..
  43. Chen Y, Shu X, Su Z, Lin R, Zhang H, Yuan W, et al. A Low-Normal Free Triiodothyronine Level Is Associated with Adverse Prognosis in Euthyroid Patients with Heart Failure Receiving Cardiac Resynchronization Therapy. Int Heart J. 2017;: pubmed publisher
    ..Multivariate Cox regression analyses disclosed that a lower-normal fT3 level (HR = 0.648, P = 0.009) and CRT response (HR = 0...
  44. Shrestha S, Zhu J, Wang Q, Du X, Liu F, Jiang J, et al. Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway. Int J Oncol. 2017;51:1249-1260 pubmed publisher
    ..that the combinational treatment enhanced the repression of nuclear translocation of NF-κB and their binding on COX-2 promoter via inhibiting IKKβ activity, resulting in inhibition of COX-2 expression...
  45. Tahara T, Mori K, Mochizuki M, Ishiyama R, Noda M, Hoshi H, et al. Tolvaptan is effective in treating patients with refractory ascites due to cirrhosis. Biomed Rep. 2017;7:558-562 pubmed publisher
    ..05). Factors associated with survival were also analyzed using the Cox proportional hazard model...
  46. Rogasch J, Hundsdoerfer P, Furth C, Wedel F, Hofheinz F, Krüger P, et al. Individualized risk assessment in neuroblastoma: does the tumoral metabolic activity on 123I-MIBG SPECT predict the outcome?. Eur J Nucl Med Mol Imaging. 2017;44:2203-2212 pubmed publisher
    ..Primary tumour MTV and ASP were defined using semiautomatic thresholds. Cox regression analysis, receiver operating characteristic analysis (cut-off determination) and Kaplan-Meier analysis ..
  47. Liu X, Qin S, Wang Z, Xu J, Xiong J, Bai Y, et al. Early presence of anti-angiogenesis-related adverse events as a potential biomarker of antitumor efficacy in metastatic gastric cancer patients treated with apatinib: a cohort study. J Hematol Oncol. 2017;10:153 pubmed publisher
    ..Time-to-event variables were assessed using Kaplan-Meier methods and Cox proportional hazard regression models. Binary endpoints were assessed using logistic regression models...
  48. Indini A, Schiavello E, Biassoni V, Bergamaschi L, Magni M, Puma N, et al. Long-term safety of growth hormone replacement therapy after childhood medulloblastoma and PNET: it is time to set aside old concerns. J Neurooncol. 2017;131:349-357 pubmed publisher
    ..their disease-free and overall survival outcomes and risk of secondary malignancies using Kaplan-Meier and Cox models. Overall 65 children were consecutively collected from May 1981 to April 2013...
  49. Davis J, Suleta K, Corsi K, Booth R. A Hazard Analysis of Risk Factors of Mortality in Individuals Who Inject Drugs in Denver CO. AIDS Behav. 2017;21:1044-1053 pubmed publisher
    ..Risk factors for both all-cause and acute-toxicity related mortality were analyzed using Cox proportional hazards regression. Two-thousand seven individuals were interviewed at baseline...
  50. Hsu R, Lin C, Chang F, Huang C, Chuang H, Liu J. The association between scabies and myasthenia gravis: A nationwide population-based cohort study. J Clin Neurosci. 2017;45:115-120 pubmed publisher
    ..We tracked the subjects in both groups for a 7-year period to identify new onset MG. Cox regression analysis was performed to calculate the hazard ratio (HR) for MG...
  51. Huang X, Ye Q, Zhang Z, Huang X, Zhu Z, Chen Y, et al. Association of matrix metalloproteinase-3 gene 5A/6A polymorphism with the recurrence of ischemic stroke: A prospective observational study. Brain Res. 2017;1674:55-61 pubmed publisher
    ..IS recurrence was monitored after the index event and multivariate Cox proportional hazards model was constructed to identify factors related to future IS recurrence...
  52. Reichert S, Triebert U, Santos A, Hofmann B, Schaller H, Schlitt A, et al. Soluble form of receptor for advanced glycation end products and incidence of new cardiovascular events among patients with cardiovascular disease. Atherosclerosis. 2017;266:234-239 pubmed publisher
    ..whether peripheral sRAGE level is associated with new cardiovascular events among patients with CVD using the Cox's regression analysis...
  53. Argirion I, Weinstein S, Mannisto S, Albanes D, Mondul A. Serum Insulin, Glucose, Indices of Insulin Resistance, and Risk of Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2017;26:1519-1524 pubmed publisher
    ..Insulin and glucose were measured in fasting serum collected 5 to 12 years before diagnosis. Cox proportional hazards models were utilized to estimate the relative risk of lung cancer...
  54. Deng S, Zhu J, Huang Q, Fu W, Li Q, Chen G, et al. Lentiviral vector-mediated shRNAs targeting a functional isoform of the leptin receptor (Ob-Rb) inhibit cartilage degeneration in a rat model of osteoarthritis. Osteoarthritis Cartilage. 2017;25:1912-1921 pubmed publisher
    ..levels of pro-inflammatory mediators (TNF-α, IL-1β and IL-6) and catabolic mediators (ADAMTS-5, MMP-9, NOS-2 and COX-2) were also significantly decreased, and the expression levels of anabolic type II collagen were significantly ..
  55. Mantha S, Goldman D, Devlin S, Lee J, Zannino D, Collins M, et al. Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era. Blood. 2017;129:1763-1767 pubmed publisher
    ..7% (95% confidence interval [CI], 2.6% to 5.0%). Using multivariate Cox proportional hazards regression, the hazard ratio of HD in the first 30 days was 2.17 (95% CI, 0.84-5...
  56. Cao T, Xiang D, Liu B, Huang T, Tan B, Zeng C, et al. FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma. Oncotarget. 2017;8:65957-65968 pubmed publisher
    ..001). Additionally, multivariate Cox regression analysis showed that FZD7 overexpression was an independent prognostic factor for ESCC patients...
  57. Chesin M, Galfavy H, Sönmez C, Wong A, Oquendo M, Mann J, et al. Nonsuicidal Self-Injury Is Predictive of Suicide Attempts Among Individuals with Mood Disorders. Suicide Life Threat Behav. 2017;47:567-579 pubmed publisher
    ..Archival data from 222 mood-disordered participants were analyzed using multivariate Cox proportional hazards analysis. Participants with a youth SA were excluded...
  58. Ramirez E, Mendieta L, Flores G, Limón I. Neurogenesis and morphological-neural alterations closely related to amyloid β-peptide (25-35)-induced memory impairment in male rats. Neuropeptides. 2017;: pubmed publisher
    ..administration of the Aβ25-35 peptide were examined the morphological changes in the DG using a Golgi-Cox stain...
  59. Kashani Sabet M, Nosrati M, Miller J, Sagebiel R, Leong S, Lesniak A, et al. Prospective Validation of Molecular Prognostic Markers in Cutaneous Melanoma: A Correlative Analysis of E1690. Clin Cancer Res. 2017;23:6888-6892 pubmed publisher
    ..RFS) and overall survival (OS) was assessed using Kaplan-Meier analysis, and both univariate and multivariate Cox regression analyses...
  60. Mohamed L, El Badry O, El Ansary A, Ismael A. Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors. Bioorg Chem. 2017;72:308-314 pubmed publisher
    A new series of oxazolones and triazinones were designed and synthesized and evaluated against both COX-1 and COX-2 enzymes...
  61. Matsukuma S, Yoshimura K, Ueno T, Oga A, Inoue M, Watanabe Y, et al. Calreticulin is highly expressed in pancreatic cancer stem-like cells. Cancer Sci. 2016;107:1599-1609 pubmed publisher
    ..resection and was found to be associated with patients' clinicopathological features and disease outcomes in the Cox proportional hazard regression model...
  62. da Costa P, Cortez A, de Souza F, Mares G, Dos Santos B, Muxfeldt E. Prognostic impact of baseline urinary albumin excretion rate in patients with resistant hypertension: a prospective cohort study. J Hum Hypertens. 2017;: pubmed publisher
    ..Survival analysis by multiple Cox regression assessed the associations among endpoints, baseline UAER, glomerular filtration rate (GFR), and ABPM ..