CREB

Summary

Gene Symbol: CREB
Description: cAMP responsive element binding protein 1
Alias: CREB, CREB-1, cyclic AMP-responsive element-binding protein 1, active transcription factor CREB, cAMP-response element-binding protein-1, cyclic adenosine 3',5'-monophosphate response element binding protein, cyclic adenosine 3',5'-monophosphate response element-binding protein CREB, transactivator protein
Species: human
Products:     CREB

Top Publications

  1. Wiggin G, Soloaga A, Foster J, Murray Tait V, Cohen P, Arthur J. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002;22:2871-81 pubmed
    ..we show that these protein kinases are required for the stress-induced phosphorylation of transcription factors CREB and ATF1 in primary embryonic fibroblasts...
  2. Xie Z, Geiger T, Johnson E, Nyborg J, Druey K. RGS13 acts as a nuclear repressor of CREB. Mol Cell. 2008;31:660-70 pubmed publisher
    Cyclic AMP-induced phosphorylation of the transcription factor CREB elicits expression of genes mediating diverse biological functions...
  3. Shankar D, Cheng J, Kinjo K, Federman N, Moore T, Gill A, et al. The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell. 2005;7:351-62 pubmed
    b>CREB is a transcription factor that functions in glucose homeostasis, growth factor-dependent cell survival, and memory. In this study, we describe a role of CREB in human cancer...
  4. Piera Velazquez S, Hawkins D, Whitecavage M, Colter D, Stokes D, Jimenez S. Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res. 2007;313:1069-79 pubmed
    ..report that the human SOX9 proximal promoter is also regulated by the cyclic-AMP response element binding protein (CREB) and Sp1...
  5. Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates J, et al. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J. 2007;26:2880-9 pubmed
    A number of hormones and growth factors stimulate gene expression by promoting the phosphorylation of CREB (P-CREB), thereby enhancing its association with the histone acetylase paralogs p300 and CBP (CBP/p300)...
  6. de La Fuente C, Gupta M, Klase Z, Strouss K, Cahan P, McCaffery T, et al. Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach. Retrovirology. 2006;3:43 pubmed
    ..Tax transactivates these cellular promoters by interacting with transcription factors such as CREB/ATF, NF-kappaB, and SRF...
  7. Lee J, Kim C, Simon D, Aminova L, Andreyev A, Kushnareva Y, et al. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005;280:40398-401 pubmed
    Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established...
  8. Ram rez J, Nyborg J. Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300. J Mol Biol. 2007;372:958-69 pubmed publisher
    ..Both Tax and the cellular transcription factor CREB bind to viral cyclic AMP response elements (vCREs) located in the viral promoter...
  9. Shi Y, Venkataraman S, Dodson G, Mabb A, Leblanc S, Tibbetts R. Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci U S A. 2004;101:5898-903 pubmed
    ..we describe a signal transduction pathway linking ATM directly to the Ca(2+)/cAMP response element-binding protein, CREB, a transcription factor that regulates cell growth, homeostasis, and survival...
  10. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham J, et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A. 2003;100:12147-52 pubmed
    ..A protein, termed transducer of regulated cAMP response element-binding protein (CREB) (TORC1), was identified that activated expression through the variant CRE and consensus CRE sites...

Detail Information

Publications62

  1. Wiggin G, Soloaga A, Foster J, Murray Tait V, Cohen P, Arthur J. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002;22:2871-81 pubmed
    ..we show that these protein kinases are required for the stress-induced phosphorylation of transcription factors CREB and ATF1 in primary embryonic fibroblasts...
  2. Xie Z, Geiger T, Johnson E, Nyborg J, Druey K. RGS13 acts as a nuclear repressor of CREB. Mol Cell. 2008;31:660-70 pubmed publisher
    Cyclic AMP-induced phosphorylation of the transcription factor CREB elicits expression of genes mediating diverse biological functions...
  3. Shankar D, Cheng J, Kinjo K, Federman N, Moore T, Gill A, et al. The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell. 2005;7:351-62 pubmed
    b>CREB is a transcription factor that functions in glucose homeostasis, growth factor-dependent cell survival, and memory. In this study, we describe a role of CREB in human cancer...
  4. Piera Velazquez S, Hawkins D, Whitecavage M, Colter D, Stokes D, Jimenez S. Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res. 2007;313:1069-79 pubmed
    ..report that the human SOX9 proximal promoter is also regulated by the cyclic-AMP response element binding protein (CREB) and Sp1...
  5. Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates J, et al. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J. 2007;26:2880-9 pubmed
    A number of hormones and growth factors stimulate gene expression by promoting the phosphorylation of CREB (P-CREB), thereby enhancing its association with the histone acetylase paralogs p300 and CBP (CBP/p300)...
  6. de La Fuente C, Gupta M, Klase Z, Strouss K, Cahan P, McCaffery T, et al. Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach. Retrovirology. 2006;3:43 pubmed
    ..Tax transactivates these cellular promoters by interacting with transcription factors such as CREB/ATF, NF-kappaB, and SRF...
  7. Lee J, Kim C, Simon D, Aminova L, Andreyev A, Kushnareva Y, et al. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005;280:40398-401 pubmed
    Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established...
  8. Ram rez J, Nyborg J. Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300. J Mol Biol. 2007;372:958-69 pubmed publisher
    ..Both Tax and the cellular transcription factor CREB bind to viral cyclic AMP response elements (vCREs) located in the viral promoter...
  9. Shi Y, Venkataraman S, Dodson G, Mabb A, Leblanc S, Tibbetts R. Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci U S A. 2004;101:5898-903 pubmed
    ..we describe a signal transduction pathway linking ATM directly to the Ca(2+)/cAMP response element-binding protein, CREB, a transcription factor that regulates cell growth, homeostasis, and survival...
  10. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham J, et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A. 2003;100:12147-52 pubmed
    ..A protein, termed transducer of regulated cAMP response element-binding protein (CREB) (TORC1), was identified that activated expression through the variant CRE and consensus CRE sites...
  11. Illario M, Giardino Torchia M, Sankar U, Ribar T, Galgani M, Vitiello L, et al. Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. Blood. 2008;111:723-31 pubmed
    ..These results reveal a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.
  12. Geiger T, Sharma N, Kim Y, Nyborg J. The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB. Mol Cell Biol. 2008;28:1383-92 pubmed
    ..Tax function is strictly dependent upon the cellular transcription factor CREB, and together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription...
  13. Screaton R, Conkright M, Katoh Y, Best J, Canettieri G, Jeffries S, et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell. 2004;119:61-74 pubmed
    ..pancreatic islet cell viability in part via the calcium- and cAMP-dependent activation of the transcription factor CREB. Here, we describe a signaling module that mediates the synergistic effects of these pathways on cellular gene ..
  14. Spooren A, Kooijman R, Lintermans B, Van Craenenbroeck K, Vermeulen L, Haegeman G, et al. Cooperation of NFkappaB and CREB to induce synergistic IL-6 expression in astrocytes. Cell Signal. 2010;22:871-81 pubmed publisher
    ..Simultaneous induction with isoproterenol and TNF-alpha was moreover associated with combined recruitment of CREB and p65 to the native IL-6 promoter...
  15. Melnikova V, Mourad Zeidan A, Lev D, Bar Eli M. Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. J Biol Chem. 2006;281:2911-22 pubmed
    Overexpression of cAMP-response element (CRE)-binding protein (CREB) and activating transcription factor (ATF) 1 contributes to melanoma progression and metastasis at least in part by promoting tumor cell survival and stimulating matrix ..
  16. Shankar E, Krishnamurthy S, Paranandi R, Basu A. PKCepsilon induces Bcl-2 by activating CREB. Int J Oncol. 2010;36:883-8 pubmed
    ..Knockdown of PKCepsilon decreased phosphorylation of cAMP response element-binding protein (CREB) at Ser133 in MDA-MB-231 cells, and depletion of CREB by siRNA decreased Bcl-2 at both the protein and mRNA levels...
  17. Laneve P, Gioia U, Andriotto A, Moretti F, Bozzoni I, Caffarelli E. A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation. Nucleic Acids Res. 2010;38:6895-905 pubmed publisher
    ..master transcriptional factors RE1-silencing transcription factor (REST) and cAMP-response element binding protein (CREB) on miR-9-2 promoter induces miRNA expression during differentiation...
  18. Comerford K, Leonard M, Karhausen J, Carey R, Colgan S, Taylor C. Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A. 2003;100:986-91 pubmed
    ..previously shown to involve phosphorylation-dependent degradation of the cAMP-response element-binding protein (CREB)...
  19. Zhang Y, Bharadwaj U, Logsdon C, Chen C, Yao Q, Li M. ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. Clin Cancer Res. 2010;16:1423-30 pubmed publisher
    ..The activity of cAMP response element-binding protein (CREB) is examined by a promoter activity assay...
  20. Yang C, Li X, Wang Y, Zhao L, Chen W. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene. 2012;496:8-16 pubmed publisher
    ..in western blot analysis, p300 (encoded by EP300) and its coactivator cAMP response element-binding protein (CREB) level were significantly down-regulated...
  21. Kim Y, Ram rez J, Mick J, Giebler H, Yan J, Nyborg J. Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation. J Biol Chem. 2007;282:18750-7 pubmed publisher
    ..elements (CREs), which are recognized by the cellular transcription factor cAMP-response element-binding protein (CREB). Tax binds to GC-rich sequences that immediately flank the CREs...
  22. Ban N, Yamada Y, Someya Y, Ihara Y, Adachi T, Kubota A, et al. Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression. Diabetes. 2000;49:1142-8 pubmed
    ..islets, ATF-2 enhanced glucose-induced insulin promoter activity, whereas cAMP response element-binding protein (CREB) repressed it...
  23. Deak M, Clifton A, Lucocq L, Alessi D. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998;17:4426-41 pubmed
    ..MSK1 is localized in the nucleus of unstimulated or stimulated cells, and phosphorylates CREB at Ser133 with a Km value far lower than PKA, MAPKAP-K1(p90Rsk) and MAPKAP-K2...
  24. Xing J, Ginty D, Greenberg M. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996;273:959-63 pubmed
    ..growth factors activate the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB), a critical regulator of immediate early gene transcription...
  25. Radhakrishnan I, Pérez Alvarado G, Parker D, Dyson H, Montminy M, Wright P. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell. 1997;91:741-52 pubmed
    The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner...
  26. Zhou Q, Gedrich R, Engel D. Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB. J Virol. 1995;69:4323-30 pubmed
    ..that the mechanism of transcriptional repression by YY1 might involve a direct interaction with members of the ATF/CREB family of transcription factors...
  27. Arias J, Alberts A, Brindle P, Claret F, Smeal T, Karin M, et al. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 1994;370:226-9 pubmed
    ..of numerous genes, for example, through the protein kinase-A (PKA)-mediated phosphorylation of transcription factor CREB at Ser 133...
  28. Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb M. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J. 1996;15:4629-42 pubmed
    ..regulates gene expression at a cyclic-AMP response element (CRE) by stimulating the transcriptional activity of CREB. The activation of CREB is prevented by a dominant negative mutant of Ras and triggered via the same site (Ser133) ..
  29. Huang Y, Chang C, Huang T, Hsieh Y, Shih H. Daxx interacts with and modulates the activity of CREB. Cell Cycle. 2012;11:99-108 pubmed publisher
    The phosphorylation of cAMP response element-binding protein (CREB) induced by the cAMP-dependent protein kinase A (PKA) elicits the recruitment of CREB-binding protein (CBP) for activating cAMP responsive gene expression...
  30. Kim Y, Cho S, Kim S, Jang H, Seo Y. Effects of Extremely Low Frequency Electromagnetic Fields on Melanogenesis through p-ERK and p-SAPK/JNK Pathways in Human Melanocytes. Int J Mol Sci. 2017;18: pubmed publisher
    ..Phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB) levels were higher than controls in cells exposed to ELF-EMFs at 50-75 Hz...
  31. Mayr B, Guzman E, Montminy M. Glutamine rich and basic region/leucine zipper (bZIP) domains stabilize cAMP-response element-binding protein (CREB) binding to chromatin. J Biol Chem. 2005;280:15103-10 pubmed
    We have examined the dynamics of cAMP-response element-binding protein (CREB) binding to chromatin in live cells using fluorescence recovery after photobleaching (FRAP)...
  32. Sun Y, Byon C, Yang Y, Bradley W, Dell Italia L, Sanders P, et al. Dietary potassium regulates vascular calcification and arterial stiffness. JCI Insight. 2017;2: pubmed publisher
    ..the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification...
  33. Ciani E, Guidi S, Della Valle G, Perini G, Bartesaghi R, Contestabile A. Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation. J Biol Chem. 2002;277:49896-902 pubmed
    The transcription factor cAMP-response element-binding protein (CREB) mediates survival in many cells, including neurons...
  34. Kronke G, Bochkov V, Huber J, Gruber F, Bluml S, Furnkranz A, et al. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J Biol Chem. 2003;278:51006-14 pubmed
    ..The cAMP-responsive element-binding protein (CREB) was phosphorylated via these pathways in response to OxPAPC treatment and expression of a dominant-negative mutant ..
  35. Pearce A, Sanders L, Brighton P, Rana S, Konje J, Willets J. Reciprocal regulation of β2-adrenoceptor-activated cAMP response-element binding protein signalling by arrestin2 and arrestin3. Cell Signal. 2017;38:182-191 pubmed publisher
    ..In the myometrium cAMP-driven modulation of cell phenotype is facilitated by CREB activity, however despite the importance of CREB signalling in the promotion of myometrial quiescence during ..
  36. Wang X, Li W, Williams M, Terada N, Alessi D, Proud C. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 2001;20:4370-9 pubmed
    ..In contrast, regulation of eEF2 by stimuli that activate Erk is insensitive to rapamycin, but blocked by inhibitors of MEK/Erk signalling, consistent with the involvement of p90(RSK1). ..
  37. Lee J, Ryu H, Kim J, Jung T, Park S, Lee Y. Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells. Arch Pharm Res. 2017;40:807-817 pubmed publisher
    ..transcription factor (MITF) in B16F10 cells, while it did not affect cAMP response element binding protein (CREB) phosphorylation. Additionally, gomisin N activated AKT phosphorylation, which inhibits MITF expression...
  38. Sonntag T, Moresco J, Vaughan J, Matsumura S, Yates J, Montminy M. Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. PLoS ONE. 2017;12:e0173013 pubmed publisher
    ..messenger cAMP stimulates cellular gene expression via the PKA-mediated phosphorylation of the transcription factor CREB and through dephosphorylation of the cAMP-responsive transcriptional coactivators (CRTCs)...
  39. Shi F, Shang L, Yang L, Jiang Y, Wang X, Hao J, et al. Neuropilin-1 contributes to esophageal squamous cancer progression via promoting P65-dependent cell proliferation. Oncogene. 2017;: pubmed publisher
    ..NRP1 regulates P65 transcription by activating cAMP responsive element binding protein (CREB)...
  40. Ahluwalia A, Jones M, Szabo S, Tarnawski A. Aging impairs transcriptional regulation of vascular endothelial growth factor in human microvascular endothelial cells: implications for angiogenesis and cell survival. J Physiol Pharmacol. 2014;65:209-15 pubmed
    ..Since P-STAT3 and P-CREB are transcription factors that, in association with HIF-1α, can activate VEGF gene expression in some cells (e.g...
  41. Jana M, Ghosh S, Pahan K. Upregulation of Myelin Gene Expression by a Physically-Modified Saline via Phosphatidylinositol 3-Kinase-Mediated Activation of CREB: Implications for Multiple Sclerosis. Neurochem Res. 2017;: pubmed publisher
    ..the mechanisms, we found that RNS60 treatment induced the activation of cAMP response element binding protein (CREB) in oligodendrocytes, ultimately leading to the recruitment of CREB to the promoters of myelin-specific genes...
  42. Sangerman J, Lee M, Yao X, Oteng E, Hsiao C, Li W, et al. Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2. Blood. 2006;108:3590-9 pubmed
    ..p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP response element (CRE) binding protein (CREB), are intimately involved in fetal hemoglobin induction by these agents...
  43. Lazary J, Juhasz G, Anderson I, Jacob C, Nguyen T, Lesch K, et al. Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality. Eur Neuropsychopharmacol. 2011;21:63-70 pubmed publisher
    ..Our results suggest that genetic epistasis in post-receptor signaling pathways in memory systems may have relevance for depression and its treatment. ..
  44. Kaplan A, Keenan T, Scott R, Zhou X, Bourchouladze R, McRiner A, et al. Identification of 5-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-Carboxamides as Novel and Selective Monoamine Oxidase B Inhibitors Used to Improve Memory and Cognition. ACS Chem Neurosci. 2017;: pubmed publisher
    ..demonstrated that the transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) is a master control gene for memory formation...