Cx43

Summary

Gene Symbol: Cx43
Description: gap junction protein alpha 1
Alias: AVSD3, CMDR, CX43, EKVP, GJAL, HLHS1, HSS, ODDD, PPKCA, gap junction alpha-1 protein, connexin-43, gap junction 43 kDa heart protein, gap junction protein, alpha 1, 43kDa
Species: human

Top Publications

  1. pmc Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia
    William A Paznekas
    Department of Pediatrics, Center for Craniofacial Development and Disorders, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Hum Genet 72:408-18. 2003
  2. ncbi The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    Baofeng Yang
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang 150086, China
    Nat Med 13:486-91. 2007
  3. pmc Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations
    E Oviedo-Orta
    Department of Medical Biochemistry and Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Immunology 99:578-90. 2000
  4. ncbi Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, Rome 00158, Italy
    J Biol Chem 278:41294-301. 2003
  5. ncbi Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Surg Res 142:137-42. 2007
  6. ncbi Corticotropin-releasing hormone activates connexin 43 via activator protein-1 transcription factor in human myometrial smooth muscle cells
    Xiang Wu
    Dept of Gynecology and Obstetrics, The Second Xiangya Hospital, Central South Univ, Changsha, Hunan 410011, China
    Am J Physiol Endocrinol Metab 293:E1789-94. 2007
  7. doi Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists
    Martine Tencé
    College de France, Center for Interdisciplinary Research in Biology CIRB, CNRS UMR 7241, INSERM U1050, Paris, France
    Cell Signal 24:86-98. 2012
  8. ncbi Connexin family members target to lipid raft domains and interact with caveolin-1
    Anne Lane Schubert
    Department of Molecular Pharmacology and Albert Einstein Cancer Center and Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 41:5754-64. 2002
  9. pmc Human mesenchymal stem cells make cardiac connexins and form functional gap junctions
    Virginijus Valiunas
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    J Physiol 555:617-26. 2004
  10. pmc Abnormal connexin43 in arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 mutations
    Lee M Fidler
    Heart Centre Cardiology Division, The Hospital for Sick Children, Toronto, ON, Canada
    J Cell Mol Med 13:4219-28. 2009

Research Grants

  1. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
  2. Connexin Distribution in Physiological Versus Pathological Cardiac Hypertrophy
    Michael R Zile; Fiscal Year: 2013
  3. Cx43 phosphorylation modulates Kras mediated pancreas cancer progression
    Paul D Lampe; Fiscal Year: 2012
  4. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2013
  5. Paul D Lampe; Fiscal Year: 2016
  6. Guy A Perkins; Fiscal Year: 2015
  7. Paul L Sorgen; Fiscal Year: 2016
  8. INTERCELLULAR COMMUNICATION IN THE LENS
    Lisa Ebihara; Fiscal Year: 2013
  9. GENETIC STUDIES OF ODDD
    Ethylin Wang Jabs; Fiscal Year: 2010
  10. Connexin 43 Hemichannels and Signaling In Bone
    LILIAN IRENE PLOTKIN; Fiscal Year: 2012

Detail Information

Publications248 found, 100 shown here

  1. pmc Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia
    William A Paznekas
    Department of Pediatrics, Center for Craniofacial Development and Disorders, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Hum Genet 72:408-18. 2003
    ..The human connexin 43 gene, or GJA1, is located at human chromosome 6q22-q23 within the candidate region for the oculodentodigital ..
  2. ncbi The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    Baofeng Yang
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang 150086, China
    Nat Med 13:486-91. 2007
    ..1) and GJA1 (which encodes connexin 43), and this likely accounts at least in part for its arrhythmogenic potential...
  3. pmc Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations
    E Oviedo-Orta
    Department of Medical Biochemistry and Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Immunology 99:578-90. 2000
    ..Connexin43 (Cx43) mRNA was expressed in peripheral blood and tonsil lymphocytes, but Cx40 mRNA expression was confined to tonsil-..
  4. ncbi Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, Rome 00158, Italy
    J Biol Chem 278:41294-301. 2003
    ..carcinoma cell lines to ET-1 led to a 50-75% inhibition in intercellular communication and to a decrease in the connexin 43 (Cx43)-based gap junction plaques...
  5. ncbi Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Surg Res 142:137-42. 2007
    ..It is our hypothesis that increased connexin43 expression following stimulation of VSMCs with Ang II and IGF-1 contributes to more proliferation in saphenous vein (SV) than in the internal mammary artery (IMA)...
  6. ncbi Corticotropin-releasing hormone activates connexin 43 via activator protein-1 transcription factor in human myometrial smooth muscle cells
    Xiang Wu
    Dept of Gynecology and Obstetrics, The Second Xiangya Hospital, Central South Univ, Changsha, Hunan 410011, China
    Am J Physiol Endocrinol Metab 293:E1789-94. 2007
    Corticotropin-releasing hormone (CRH) and connexin 43 (Cx43) play crucial roles in uterine contraction and the onset of labor...
  7. doi Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists
    Martine Tencé
    College de France, Center for Interdisciplinary Research in Biology CIRB, CNRS UMR 7241, INSERM U1050, Paris, France
    Cell Signal 24:86-98. 2012
    ..are extensively coupled through gap junctions (GJs) that are composed of channels mostly constituted by connexin43 (Cx43)...
  8. ncbi Connexin family members target to lipid raft domains and interact with caveolin-1
    Anne Lane Schubert
    Department of Molecular Pharmacology and Albert Einstein Cancer Center and Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 41:5754-64. 2002
    ..We show that connexin 43 (Cx43) colocalizes, cofractionates, and coimmunoprecipitates with caveolin-1...
  9. pmc Human mesenchymal stem cells make cardiac connexins and form functional gap junctions
    Virginijus Valiunas
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    J Physiol 555:617-26. 2004
    ..Immunostaining revealed typical punctate staining for Cx43 and Cx40 along regions of intimate cell-to-cell contact between hMSCs...
  10. pmc Abnormal connexin43 in arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 mutations
    Lee M Fidler
    Heart Centre Cardiology Division, The Hospital for Sick Children, Toronto, ON, Canada
    J Cell Mol Med 13:4219-28. 2009
    ..Reduced connexin43 expression and localization to the intercalated disk occurs in heterozygous human PKP-2 mutations, potentially explaining the delayed conduction and propensity to develop arrhythmias seen in this disease...
  11. ncbi Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells
    Xi Li
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine SJTU SM, Shanghai, China
    J Cell Physiol 208:594-601. 2006
    ..conditional expression of AML1-ETO by the ecdysone-inducible system dramatically increases the expression of connexin 43 (CX43), together with growth arrest at G1 phase in leukemic U937 cells...
  12. pmc Zonula occludens-1 and connexin 43 expression in the failing human heart
    Sawa Kostin
    Core Lab for Molecular and Structural Biology, W G Kerckhoff Institute, Max Planck Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany
    J Cell Mol Med 11:892-5. 2007
    Focal disorganization of gap junctional distribution and down-regulation of the major gap junctional protein connexin 43 are typical features of myocardial remodelling in the failing human heart...
  13. pmc Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Mol Cell Cardiol 44:882-90. 2008
    ..We assessed connexin 43 (Cx43) expression and its role in angiotensin II-induced proliferation and migration of smooth muscle cells and ..
  14. pmc Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites
    Jia Chen
    Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Kowloon, Hong Kong
    EMBO J 27:2113-23. 2008
    ..together with the well-separated canonical carboxyl tail-binding pocket in each PDZ unit in binding to connexin43 (Cx43)...
  15. pmc Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43
    Gabriel J Villares
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 69:6730-7. 2009
    ..cDNA microarray and Western blot analyses reveal that the gap junctional intracellular communication molecule connexin 43 (Cx-43), known to be involved in tumor cell diapedesis and attachment to endothelial cells, is significantly ..
  16. pmc Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue
    Ann Hjelm Cluff
    Department of Woman and Child Health, Division for Obstetrics and Gynaecology, Karolinska University Hospital Solna, S 171 76 Stockholm, Sweden
    Reprod Biol Endocrinol 4:24. 2006
    Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium...
  17. ncbi Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication
    B N Giepmans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute and Centre for Biomedical Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 276:8544-9. 2001
    Cell-cell communication via connexin-43 (Cx43)-based gap junctions is transiently inhibited by certain mitogens, but the underlying regulatory mechanisms are incompletely understood...
  18. ncbi A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover
    Marc A Thomas
    Institute of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland
    J Cell Sci 116:2213-22. 2003
    ....
  19. ncbi The correlation between aberrant connexin 43 mRNA expression induced by promoter methylation and nodal micrometastasis in non-small cell lung cancer
    Jung Ta Chen
    Department of Pathology, Veteran General Hospital Taichung, Taichung 402, Taiwan, ROC
    Clin Cancer Res 9:4200-4. 2003
    ..Although aberrant Cx43 gene expression was linked with lung tumorigenesis, our understanding to the mechanism was still limited...
  20. pmc Expression of Gja1 correlates with the phenotype observed in oculodentodigital syndrome/type III syndactyly
    R Richardson
    J Med Genet 41:60-7. 2004
  21. ncbi Some oculodentodigital dysplasia-associated Cx43 mutations cause increased hemichannel activity in addition to deficient gap junction channels
    Radoslaw Dobrowolski
    Institute of Genetics, University of Bonn, Roemerstrasse 164, 53117, Bonn, Germany
    J Membr Biol 219:9-17. 2007
    ..ODDD is caused by mutations in the GJA1 gene encoding the gap junction protein connexin43 (Cx43)...
  22. ncbi [Decreased expression of Cx32 and Cx43 and their function of gap junction intercellular communication in gastric cancer]
    Jin Wu
    The Seventh Medical Department, Tumor Hospital of Harbin Medical University, Harbin 150040, China
    Zhonghua Zhong Liu Za Zhi 29:742-7. 2007
    ..The aim of this study was to investigate the expression of connexin (Cx) and the function of gap junction intercellular communication (GJIC) in the carcinogenesis, progression and metastasis of gastric cancers...
  23. doi Clathrin and Cx43 gap junction plaque endoexocytosis
    Beth M Nickel
    Department of Cell Biology and Physiology, University of Pittsburgh, School of Medicine, 324 South Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 374:679-82. 2008
    ..We report here that clathrin associates with both connexin 43 (Cx43) gap junction plaques and pentilaminar gap junction vesicles...
  24. doi Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
    Edward Leithe
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo and Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    J Cell Sci 122:3883-93. 2009
    ..Here, we show that ubiquitin is strongly relocalized to connexin-43 (Cx43; also known as Gja1) gap junction plaques in response to activation of protein kinase C...
  25. doi Expression and significance of Cx43 and E-cadherin in gastric cancer and metastatic lymph nodes
    Bo Tang
    General Surgery Center of PLA, Southwest Hospital, The Third Military Medical University, Shapingba District, Chongqing, China
    Med Oncol 28:502-8. 2011
    b>Connexin 43(Cx43) and E-cadherin are concurrently expressed in many tumors and were ever classified as tumor suppressors in primary tumors (PT), whereas recent studies showed that these two proteins played specific roles in tumor ..
  26. doi Androgen excess down-regulates connexin43 in a human granulosa cell line
    Cheng Hsuan Wu
    Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
    Fertil Steril 94:2938-41. 2010
    ..High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients...
  27. doi Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin
    Shi cang Yu
    Institute of Pathology and Southwest Cancer Center, Third Military Medical University, Chongqing, China
    Stem Cells 30:108-20. 2012
    ..GSCs expressed very low level of connexins, Cx43 in particular, which are key components of gap junction...
  28. ncbi Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality
    S H Britz-Cunningham
    Department of Physiology, Loma Linda University, CA 92354, USA
    N Engl J Med 332:1323-9. 1995
    ..We hypothesized that mutations altering sites critical to this regulation would lead to functional or developmental abnormalities of the heart...
  29. ncbi Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein
    B J Warn-Cramer
    Department of Molecular Carcinogenesis, Cancer Research Center of Hawaii, School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    J Biol Chem 271:3779-86. 1996
    ....
  30. ncbi Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions
    M Y Kanemitsu
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 272:22824-31. 1997
    ..in v-src transformed cells is accompanied by tyrosine phosphorylation of the gap junction protein, connexin 43 (Cx43). Cx43 is phosphorylated on tyrosine by v-Src...
  31. ncbi Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase
    B J Warn-Cramer
    Molecular Carcinogenesis Section, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    J Biol Chem 273:9188-96. 1998
    ..Studies with connexin-43 mutants suggest that MAP kinase phosphorylation at one or more of the tandem Ser279/Ser282 sites is sufficient to disrupt gap junctional intercellular communication...
  32. ncbi The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein
    B N Giepmans
    Division of Cellular Biochemistry The Netherlands Cancer Institute Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Curr Biol 8:931-4. 1998
    ..Connexin43 (Cx43) is the most widely expressed and the most well-studied member of this family...
  33. ncbi c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes
    T Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 276:1780-8. 2001
    ..We therefore conclude that c-Src regulates the interaction between connexin-43 and ZO-1 through tyrosine phosphorylation and through the binding of its SH2 domain to connexin-43...
  34. ncbi Gap junction channels formed by coexpressed connexin40 and connexin43
    V Valiunas
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794, USA
    Am J Physiol Heart Circ Physiol 281:H1675-89. 2001
    ..We examined the potential interaction of connexin Cx43 and Cx40 in HeLa cells sequentially stably transfected with these two connexins...
  35. ncbi Transduction of cell survival signals by connexin-43 hemichannels
    Lilian I Plotkin
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, and the Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 277:8648-57. 2002
    ....
  36. ncbi Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication
    Hong Qin
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 277:29132-8. 2002
    ..study human breast tumor cells were found to exhibit diverse gap junction phenotypes including (a) undetectable Cx43 and no intercellular communication (HBL100); (b) low levels of Cx43 and sparse intercellular communication (MDA-MB-..
  37. pmc Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells
    Undine Lauf
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:10446-51. 2002
    ..investigated delivery of GJ channel subunits (connexons) assembled from green fluorescent protein (GFP)-tagged connexin 43 (Cx43) to the PM and GJs in living cells...
  38. ncbi Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Biol Chem 277:50087-97. 2002
    ..Our results suggest that impaired trafficking, and not the inability to form gap junctions, is the major cause of communication deficiency in human prostate cancer cell lines...
  39. ncbi The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth
    Xitong Dang
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada
    Mol Cell Biochem 242:35-8. 2003
    ..To define the role of a non-channel forming domain of connexin-43 (Cx43), the main constituent of cardiomyocyte gap junctions, on growth regulation, we expressed its C-terminal portion (..
  40. ncbi Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence
    George D Carystinos
    Department of Pharmacology and Therapeutics and the Montreal Centre for Experimental Therapeutics in Cancer, Lady Davis Institute of the Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Canada
    Mol Pharmacol 63:821-31. 2003
    b>Connexin 43 (Cx43) is essential for survival and is tightly regulated at the transcriptional and post-transcriptional levels...
  41. ncbi Mutations in the second extracellular region of connexin 43 prevent localization to the plasma membrane, but do not affect its ability to suppress cell growth
    Gordana Olbina
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, San Diego, CA 92186 5800, USA
    Mol Cancer Res 1:690-700. 2003
    b>Connexin 43 (Cx43), the most widely expressed gap junction protein, has a role in regulation of cell growth...
  42. pmc Gating and regulation of connexin 43 (Cx43) hemichannels
    Jorge E Contreras
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:11388-93. 2003
    b>Connexin 43 (Cx43) nonjunctional or "unapposed" hemichannels can open under physiological or pathological conditions...
  43. ncbi Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes
    Bradley W Doble
    Department of Human Anatomy and Cell Sciences, Faculty of Medicine, University of Manitoba, Winnipeg MB R3E 3J7, Canada
    J Cell Sci 117:507-14. 2004
    ..gap junction coupling and protein kinase C (PKC)-mediated phosphorylation of the gap junction protein connexin43 (Cx43)...
  44. ncbi A homozygous GJA1 gene mutation causes a Hallermann-Streiff/ODDD spectrum phenotype
    Antonio Pizzuti
    Ospedale Casa Sollievo della Sofferenza and Istituto CSS Mendel, Roma, Italy
    Hum Mutat 23:286. 2004
    ..However, while ODDD is a dominantly inherited disorder due to mutations in the connexin 43 gene GJA1, the inheritance pattern of the HSS syndrome is still debated...
  45. ncbi Connexins 26, 30, and 43: differences among spontaneous, chronic, and accelerated human wound healing
    Johanna M Brandner
    Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Invest Dermatol 122:1310-20. 2004
    ..We analyzed the staining patterns of the GJ proteins Cx26, Cx30, and Cx43 in human cutaneous wound healing and compared ex vivo spontaneous wound healing to non-healing wounds (chronic leg ..
  46. pmc Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368
    Theresa S Richards
    Division of Basic and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 167:555-62. 2004
    Phosphorylation of connexin43 (Cx43) on serine368 (S368) has been shown to decrease gap junctional communication via a reduction in unitary channel conductance...
  47. pmc Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells
    Hicham Lahlou
    INSERM U531, Institut Louis Bugnard, CHU Rangueil, TSA 50032, 31059 Toulouse Cedex 9, France
    Mol Cell Biol 25:4034-45. 2005
    ..by the antiproliferative somatostatin receptor 2 (sst2) is due to overexpression of endogenous connexins Cx26 and Cx43 and consequent formation of functional gap junctions...
  48. pmc Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture
    Mary Ann Pollmann
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada
    Breast Cancer Res 7:R522-34. 2005
    ..The molecular mechanisms regulating tumor cell diapedesis are poorly understood, but may involve heterocellular gap junctional intercellular communication (GJIC) between tumor cells and endothelial cells...
  49. ncbi Modulation of connexin43 alters expression of osteoblastic differentiation markers
    Zhongyong Li
    Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine 500 University Dr, Hershey, 17033, USA
    Am J Physiol Cell Physiol 290:C1248-55. 2006
    ..19 (hfob/cx43(-))...
  50. ncbi Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel
    Derek L Beahm
    Department of Biological Sciences, State University of New York, Buffalo, New York 14260, USA
    J Biol Chem 281:7994-8009. 2006
    ..This mutant may be useful as a tool for knocking down or knocking out connexin function in vitro or in vivo...
  51. ncbi Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia
    Taizen Nakase
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Sensyu Kubota Machi, Akita 010 0874, Japan
    Glia 54:369-75. 2006
    ..Moreover, astrocytes establish a glial network and communicate through gap junctions in the brain. Connexin 43 (Cx43) is one of major component proteins in astrocytic gap junctions...
  52. ncbi Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia
    Xiang Qun Gong
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 282:19190-202. 2007
    Oculodentodigital dysplasia (ODDD) is a congenital autosomal dominant disorder with phenotypic variability, which has been associated with mutations in the GJA1 gene encoding connexin43 (Cx43)...
  53. ncbi Identification of the calmodulin binding domain of connexin 43
    Yubin Zhou
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA
    J Biol Chem 282:35005-17. 2007
    ..This report identifies a CaM-binding motif comprising residues 136-158 in the intracellular loop of Cx43. A 23-mer peptide encompassing this CaM-binding motif was shown to bind Ca(2+)-CaM with 1:1 stoichiometry by using ..
  54. ncbi Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1
    Alexandra F Bruce
    National Heart and Lung Institute, Imperial College London, Guy Scadding Building, London, UK
    Cardiovasc Res 77:757-65. 2008
    Remodelling of gap junctions, involving reduction of total gap junction quantity and down-regulation of connexin43 (Cx43), contributes to the arrhythmic substrate in congestive heart failure...
  55. pmc Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes
    Stephanie Langlois
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada
    Mol Biol Cell 19:912-28. 2008
    Connexin43 (Cx43) has been reported to interact with caveolin (Cav)-1, but the role of this association and whether other members of the caveolin family bind Cx43 had yet to be established...
  56. doi TNF-alpha represses connexin43 expression in HaCat keratinocytes via activation of JNK signaling
    Chalotte Tacheau
    INSERM U697, Paris, France
    J Cell Physiol 216:438-44. 2008
    ..by the Jun-N-terminal kinase (JNK) and NFkappaB pathways downstream of TNF-alpha in the context of connexin43 (Cx43) gene expression...
  57. doi Ocular manifestations in oculodentodigital dysplasia resulting from a heterozygous missense mutation (L113P) in GJA1 (connexin 43)
    F U Musa
    Birmingham and Midland Eye Centre, City Hospital, Birmingham, UK
    Eye (Lond) 23:549-55. 2009
    To characterize the ophthalmic findings, intrafamilial variability, and molecular genetic basis of oculodentodigital dysplasia (ODDD; MIM no. 164200).
  58. pmc Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium
    M Khair ElZarrad
    Department of Pharmacology and Center for Lung Biology, University of South Alabama, North University Boulevard, Mobile, AL 36688, USA
    BMC Med 6:20. 2008
    ..We hypothesized that, in this multi-stage scheme, connexin-43 is centrally involved as a cell adhesion molecule mediating metastatic tumor attachment to the pulmonary endothelium...
  59. doi High levels of connexin 43 mRNA in high grade astrocytomas. Study of 32 cases with in situ hybridization
    Rosario Caltabiano
    Department G F Ingrassia, Section of Anatomic Pathology, University of Catania, 95123 Catania, Italy
    Acta Histochem 112:529-35. 2010
    ..The aims of the research reported here were (1) to evaluate the Cx43 protein and mRNA of both low histological grade and high histological grade astrocyte tumors; (2) to evaluate if ..
  60. doi Comparative evaluation of estrogen and progesterone receptor expression with connexins 26 and 43 in endometrial cancer
    Tomasz Lesniewicz
    Department of General Pathomorphology, Medical University of Bialystok, Waszyngtona, Bialystok, Poland
    Int J Gynecol Cancer 19:1253-7. 2009
    ..on assessment of expression of estrogen receptor alpha (ERalpha) and PRs in relation to the expression of Cx26 and Cx43 in 88 cases of endometrial cancer and analysis of these proteins' expression in comparison with anatomoclinical ..
  61. doi Connexin-based signaling in acute myelogenous leukemia (AML)
    Brynjar Foss
    Department of Health Studies, University of Stavanger, Stavanger, Norway
    Biochim Biophys Acta 1798:1-8. 2010
    ....
  62. pmc Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
    James W Smyth
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 120:266-79. 2010
    ..We anticipate that protecting the microtubule-based forward delivery apparatus of connexons could improve cell-cell coupling and reduce ischemia-related cardiac arrhythmias...
  63. pmc Ultrastructure and regulation of lateralized connexin43 in the failing heart
    Geoffrey G Hesketh
    Johns Hopkins University School of Medicine, 720 N Rutland Ave, Baltimore, MD 21205, USA
    Circ Res 106:1153-63. 2010
    ..The primary gap junction protein in the working myocardium, connexin43 (Cx43), exhibits increased localization at the lateral membranes of cardiomyocytes in a variety of heart diseases, ..
  64. doi Control of the proliferation of activated CD4+ T cells by connexins
    Ernesto Oviedo-Orta
    Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
    J Leukoc Biol 88:79-86. 2010
    ..We showed that expression of Cx43 and its phosphorylated isoforms increased in response to the engagement of CD3 and CD28...
  65. doi The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1
    Stephanie Langlois
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cancer Res 70:4222-32. 2010
    Connexin43 (Cx43) is known to have tumor-suppressive effects, but the underlying mechanisms are still poorly understood...
  66. doi The carboxy-terminal tail of connexin43 gap junction protein is sufficient to mediate cytoskeleton changes in human glioma cells
    Sophie Crespin
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, CNRS UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    J Cell Biochem 110:589-97. 2010
    Connexin43 (Cx43) is a ubiquitously expressed member of the gap junction protein family that mediates gap junction intercellular communication (GJIC) by allowing exchange of cytosolic materials...
  67. pmc Connexon-mediated cell adhesion drives microtissue self-assembly
    Brian Bao
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, RI 02912, USA
    FASEB J 25:255-64. 2011
    ..We investigated whether connexon 43 (Cx43)-mediated cell adhesion modulates self-assembly of human KGN granulosa cells, normal human fibroblasts (NHFs), and ..
  68. doi Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal
    Steve Catarino
    Centre of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Biochem J 437:255-67. 2011
    ..The tyrosine-sorting signal (YXXØ), present at amino acids 286-289 of Cx43 (connexin43), has been implicated in the internalization of the protein...
  69. pmc Investigation of the reciprocal relationship between the expression of two gap junction connexin proteins, connexin46 and connexin43
    Debarshi Banerjee
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 286:24519-33. 2011
    ..Of the three vertebrate lens connexins, two connexins, connexin43 (Cx43) and connexin46 (Cx46), show reciprocal expression and subsequent function in the lens and in lens cell culture...
  70. pmc Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues
    Lucrecia Marquez-Rosado
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Biochim Biophys Acta 1818:1985-92. 2012
    ..Connexin43 (Cx43) is the most widely and highly expressed gap junction protein, both in cell culture models and in humans, thus more ..
  71. doi Channel-independent influence of connexin 43 on cell migration
    Petra Kameritsch
    Ludwig Maximilians Universitat Munich, Germany
    Biochim Biophys Acta 1818:1993-2001. 2012
    In this review we focus on the role of connexins, especially of Cx43, as modulators of migration - a fundamental process in embryogenesis and in physiologic functions of the adult organism...
  72. pmc Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer
    Joanna Gemel
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    J Membr Biol 245:231-41. 2012
    Many tissues express multiple gap junction proteins, or connexins (Cx); for example, Cx43, Cx40, and Cx37 are coexpressed in vascular cells...
  73. pmc Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia
    Qing Shao
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada
    Mol Biol Cell 23:3312-21. 2012
    Mutations in the gene encoding connexin-43 (Cx43) cause the human development disorder known as oculodentodigital dysplasia (ODDD)...
  74. pmc The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade
    Corinne Niger
    Department of Orthopaedics, University of Maryland, School of Medicine, Baltimore, MD, USA
    J Bone Miner Res 28:1468-77. 2013
    Connexin43 (Cx43) plays a critical role in osteoblast function and bone mass accrual, yet the identity of the second messengers communicated by Cx43 gap junctions, the targets of these second messengers and how they regulate osteoblast ..
  75. ncbi Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning
    Kerstin Boengler
    Institut fur Pathophysiologie, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Cardiovasc Res 67:234-44. 2005
    b>Connexin 43 (Cx43) is involved in infarct size reduction by ischemic preconditioning (IP); the underlying mechanism of protection, however, is unknown...
  76. ncbi Novel Connexin 43 (GJA1) mutation causes oculo-dento-digital dysplasia with curly hair
    Klaus W Kjaer
    Wilhelm Johannsen Centre for Functional Genome Research, The Panum Institute Building 24 4, Department of Medical Genetics, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen N, Denmark
    Am J Med Genet A 127:152-7. 2004
    ..ocular, craniofacial, and digital anomalies, caused by mutations in the gap junction alpha-1 gene (GJA1 or Connexin 43 (CX43)) [Paznekas et al., 2003]...
  77. ncbi Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence
    E Geimonen
    Department of Obstetrics, Gynecology and Reproductive Medicine, School of Medicine, State University of New York, Stony Brook, New York 11794 8091, USA
    J Biol Chem 271:23667-74. 1996
    ..This work provides evidence that transcription of the human connexin-43 gene is induced through protein kinase C activation in uterine smooth muscle cells, and that the induction involves up-regulation and activation of c-Jun and c-Fos...
  78. pmc Are gap junction gene connexins 26, 32 and 43 of prognostic values in hepatocellular carcinoma? A prospective study
    I Shyan Sheen
    Department of Surgery, Mackay Memorial Hospital, No 92, Sec 2, Chung San North Road, Taipei, Taiwan, China
    World J Gastroenterol 10:2785-90. 2004
    ..To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues...
  79. ncbi Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease
    Dale W Laird
    Departments of Anatomy and Cell Biology and Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 283:2997-3001. 2008
    ..For instance, the most prevalent connexin in the human body is connexin-43 (Cx43), yet autosomal dominant mutations in the GJA1 gene, which encodes Cx43, exhibit modest developmental disorders ..
  80. doi Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques
    Jamie Simek
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Sci 122:554-62. 2009
    b>Connexin 43 (Cx43) is a dynamic molecule, having a short half-life of only a few hours...
  81. ncbi Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness
    X Z Liu
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0033, USA
    Hum Mol Genet 10:2945-51. 2001
    ..We have found that alterations in a fifth member of this family, GJA1 (Cx43), appear to cause a common form of deafness in African Americans...
  82. ncbi Casein kinase 1 regulates connexin-43 gap junction assembly
    Cynthia D Cooper
    Fred Hutchinson Cancer Research Center and Department of Pathobiology, University of Washington, Seattle, Washington 98109 1024, USA
    J Biol Chem 277:44962-8. 2002
    ..We have examined the role of casein kinase 1 (CK1) in connexin-43 (Cx43) gap junction assembly...
  83. ncbi A new GJA1 (connexin 43) mutation causing oculodentodigital dysplasia associated to uncommon features
    David Rivera de la Parra
    Research Unit, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico
    Ophthalmic Genet 28:198-202. 2007
    ..The disease is caused by heterozygous mutations in the 6q22-q23 located GJA1 gene, that encodes connexin 43 (Cx43). In this paper we describe a novel Cx43 mutation (G2V) found in a Mexican eight-year-old boy...
  84. ncbi Paradoxical overexpression and translocation of connexin43 in homocysteine-treated endothelial cells
    Hong Li
    Department of Medicine, State University of New York, Stony Brook, 11794, USA
    Am J Physiol Heart Circ Physiol 282:H2124-33. 2002
    ..of human umbilical vein endothelial cells (HUVEC) treated with homocysteine (Hcy) revealed that connexin43 (Cx43) was upregulated. Expression of Cx43 was increased more than twofold in Hcy-treated HUVEC...
  85. ncbi Connexin expression in mouse lung tumor
    Naoko Udaka
    Department of Pathology and Experimental Medicine, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjyo, Kumamoto, Japan
    Cancer Lett 246:224-9. 2007
    ..b>Cx43 was similarly detectable in normal lung, smaller size tumor and larger size tumor, but western blotting showed that ..
  86. ncbi Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma
    Xiang Qun Gong
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 281:31801-11. 2006
    A frameshift mutation generated from a dinucleotide deletion (780-781del) in the GJA1 gene encoding Cx43 results in a frameshift yielding 46 aberrant amino acids after residue 259 and a shortened protein of 305 residues compared with the ..
  87. doi ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation
    Elizabeth McLachlan
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    J Bone Miner Res 23:928-38. 2008
    ..dominant human disease caused by mutations in the gene (GJA1) encoding the gap junction protein, connexin43 (Cx43). The disease is characterized by craniofacial bone deformities and limb abnormalities...
  88. doi Bystander effect in glioblastoma cells with a predominant cytoplasmic localization of connexin43
    S Cottin
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    Cancer Gene Ther 15:823-31. 2008
    ..In this study, we investigated the level of expression, the localization and the functionality of connexin43 (Cx43) in three glioblastoma cell lines...
  89. doi Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms
    Tao Huang
    Department of Anatomy and Cell Biology, University of Western Ontario, London ON N6A 5C1, Canada
    J Cell Sci 126:2857-66. 2013
    Oculodentodigital dysplasia (ODDD) is mainly an autosomal dominant human disease caused by mutations in the GJA1 gene, which encodes the gap junction protein connexin43 (Cx43)...
  90. ncbi Connexin expression and turnover : implications for cardiac excitability
    J E Saffitz
    Departments of Pathology and Medicine and the Center for Cardiovascular Research, Washington University, St Louis, MO 63110, USA
    Circ Res 86:723-8. 2000
    ..Regulation of connexin degradation may be an important mechanism for adjusting intercellular coupling in the heart under normal and pathophysiological conditions...
  91. ncbi Mapping of the autosomal recessive (AR) craniometaphyseal dysplasia locus to chromosome region 6q21-22 and confirmation of genetic heterogeneity for mild AR spondylocostal dysplasia
    P Iughetti
    Departamento de Biologia, Departamento de Biologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
    Am J Med Genet 95:482-91. 2000
    ....
  92. ncbi Bisphosphonate-induced, hemichannel-mediated, anti-apoptosis through the Src/ERK pathway: a gap junction-independent action of connexin43
    L I Plotkin
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Cell Commun Adhes 8:377-82. 2001
    ..These studies establish a role for connexin43 hemichannels in bisphosphonate action, and a novel function of connexin43--beyond gap junction communication--in the regulation of survival signaling pathways...
  93. doi Splice variant IVS2-2A>G in the SLC26A5 (Prestin) gene in five Estonian families with hearing loss
    Rita Teek
    Department of Oto Rhino Laryngology, University of Tartu, Tartu, Estonia
    Int J Pediatr Otorhinolaryngol 73:103-7. 2009
    ..The aim of our study was to identify the IVS2-2A>G sequence change in the SLC26A5 (Prestin) gene in Estonian individuals with hearing loss and in their family members...
  94. doi Effect of high-frequency electromagnetic fields on trophoblastic connexins
    Franco Cervellati
    Department of Biology and Evolution, Section of General Physiology, University of Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
    Reprod Toxicol 28:59-65. 2009
    ..HF-EMF exposure significantly and selectively increased Cx40 and Cx43, without altering protein expression...
  95. doi Eps15 interacts with ubiquitinated Cx43 and mediates its internalization
    Henrique Girao
    Centre of Ophthalmology and Visual Sciences, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Sta Comba 3000 354 Coimbra, Portugal
    Exp Cell Res 315:3587-97. 2009
    ..Regulation of GJIC by degradation of Cx43 has been a matter of debate over the last two decades and both the proteasome and the lysosome have been implicated...
  96. doi Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation
    Wei Zhao
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Cell Biology, Peking University Cancer Hospital and Institute, Beijing 100142, China
    Int J Biochem Cell Biol 43:1459-68. 2011
    ..We have previously shown that transfection of connexin43 (Cx43) cDNA retarded the growth of a highly metastatic human pulmonary giant cell carcinoma cell line, PG, both in vitro ..
  97. ncbi Connexin 43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1, as discovered using protein array technology
    Ruochun Huang
    Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Cancer Res 62:2806-12. 2002
    Previously, we demonstrated that connexin 43 (cx43) suppressed the growth of human glioblastoma cells...
  98. ncbi Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins
    Vincent C Chen
    Department of Chemistry, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
    J Proteome Res 5:2123-34. 2006
    ....
  99. pmc Functional analysis of human cardiac gap junction channel mutants
    G I Fishman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 88:3525-9. 1991
    ..Furthermore, since the mutant connexins are missing several consensus phosphorylation sites, modification of these particular sites may not be required for membrane insertion or assembly of human connexin43 into functional channels...
  100. ncbi Modulation of adrenal gap junction expression
    S A Murray
    Department of Cell Biology and Physiology, University of Pittsburgh, School of Medicine, Pennsylvania 15261, USA
    Horm Metab Res 30:426-31. 1998
    ..The gap junction protein, connexin 43 (alpha 1), was detected...
  101. ncbi Heterocellular gap junctional communication between alveolar epithelial cells
    V Abraham
    Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1085-93. 2001
    ..In normal rat lung sections, connexin (Cx)32 was expressed by type II cells, whereas Cx43 was more ubiquitously expressed and Cx46 was expressed by occasional alveolar epithelial cells...

Research Grants63

  1. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
    ..These studies will delineate the mechanism of Hcy-dependent endothelial-myocyte uncoupling in cardiac arrhythmia and failure, and will have therapeutic ramifications for sudden cardiac death. ..
  2. Connexin Distribution in Physiological Versus Pathological Cardiac Hypertrophy
    Michael R Zile; Fiscal Year: 2013
    ..in microtubule network organization and MAP4 binding in causing abnormal transport and localization of connexin43 [Cx43], a gap junction protein known to undergo functionally important alterations in quantity and localization during ..
  3. Cx43 phosphorylation modulates Kras mediated pancreas cancer progression
    Paul D Lampe; Fiscal Year: 2012
    ..The 5-year overall survival for patients with PDA is less than 3%. The gap junction protein connexin43 (Cx43) is a tumor suppressor gene that is expressed in pancreatic ductal cells, the putative site of cancer origin...
  4. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2013
    ..Of the over twenty identified mammalian connexin genes, only four connexins, connexin40 (Cx40), connexin43 (Cx43), connexin45 (Cx45), and connexin 31.9 (Cx31.9), are expressed in the heart...
  5. Paul D Lampe; Fiscal Year: 2016
    ..The gap junction protein connexin43 (Cx43) is regulated via phosphorylation and its interactions with other proteins...
  6. Guy A Perkins; Fiscal Year: 2015
    ..In combination with biochemical and inhibitor analyses of wild type and mutant Cx43 proteins, the overall goal is to study these phospho-forms at electron tomographic resolution (~40-60 E) in 3D to ..
  7. Paul L Sorgen; Fiscal Year: 2016
    ..and intermolecular interactions that define the structure of the major cardiac gap junction protein connexin43 (Cx43) during pH-mediated gating and degradation...
  8. INTERCELLULAR COMMUNICATION IN THE LENS
    Lisa Ebihara; Fiscal Year: 2013
    ..Three different connexin proteins (Connexin 43 (Cx43), Connexin 46 (Cx46), Connexin 50 (Cx50)) have been identified in lens fibers...
  9. GENETIC STUDIES OF ODDD
    Ethylin Wang Jabs; Fiscal Year: 2010
    ..identified mutations (missense and small duplication) in the gap junction protein GJA1, also referred to as connexin 43, in ODDD patients...
  10. Connexin 43 Hemichannels and Signaling In Bone
    LILIAN IRENE PLOTKIN; Fiscal Year: 2012
    ..b>Cx43 is the most abundant connexin expressed in bone cells...
  11. Virginijus Valiunas; Fiscal Year: 2015
    ..Mutations in connexin43 (Cx43) have been linked to oculodentodigital dysplasia (ODDD) which manifests with bone deformities and accompanying neurological complications...
  12. Connexin-Mediated Hemichannel Activity in Experimental Periodontitis
    Karen F Ross; Fiscal Year: 2012
    ..to fluid movement above the cells (mechanical stimulation), and oral keratinocytes express predominately connexin 43 (Cx43). We hypothesize, therefore, that P...
  13. SiRNA therapeutics: Gap junction delivery in vitro and in vivo
    Richard T Mathias; Fiscal Year: 2013
    ..Our previous studies have shown that gap junctions composed of connexin43 (Cx43) are permeable to siRNAs and permeating siRNAs can subsequently reduce the mRNA levels of a specific gene...
  14. Mario Delmar; Fiscal Year: 2015
    ..the cardiac sodium channel protein, functionally interacts with PKP2 and with the gap junction protein connexin43 (Cx43)...
  15. Transfer of Metabolites through Lens Gap Junctions
    Gary Goldberg; Fiscal Year: 2005
    ..In particular, connexin43 (Cx43), Cx46, and Cx5O are needed for normal lens development and function...
  16. Mechanisms for Stem Cell Differentiation into Cardiac Myocytes
    Margaret Loewy Kirby; Fiscal Year: 2010
    ..the following sequential events drive naive stem cell differentiation into a cardiomyocyte: shared functional connexin 43 (Cx43)-derived gap junctions develop between the stem cell and an adjacent contracting cardiomyocyte (Cx43 is ..
  17. Connexin 43 gap junction dynamics in the diabetic heart
    Joseph A Palatinus; Fiscal Year: 2013
    ..Zonula occludens-1 (ZO-1) binds Connexin 43 (Cx43), and this interaction is important for gapjunction remodeling...
  18. JOHN PEARCE MORROW; Fiscal Year: 2015
    ..Further, connexin 43, the main component of the ventricular gap junction, is down regulated at the transcriptional level and the ..
  19. Joshua M Hare; Fiscal Year: 2016
    ..resulting from a combination of autologous CSCs and MSCs, 2) assess the impact of cell-cell communication by connexin 43 (Cx43)-mediated gap junctions on cardiac regeneration, and 3) assess the cell- cell interaction and efficacy of ..
  20. SIGNAL TRANSDUCTION AT FERTILIZATION
    Laurinda A Jaffe; Fiscal Year: 2012
    ..These studies will be complemented by investigations of the phosphorylation of connexin 43 on specific regulatory sites...
  21. Eliseo A Eugenin; Fiscal Year: 2016
    ..We hypothesize that Cx43 containing gap junctions (GJ) and hemichannels (uHC) amplify intercellular signals generated in few HIV infected ..
  22. Roberto Civitelli; Fiscal Year: 2016
    ..of the osteogenic lineage, and the fact that Gja1 mutations cause the human disease oculodentodigital dysplasia (ODDD), characterized by craniofacial and skeletal abnormalities, substantiate that skeletal homeostasis requires Cx43...
  23. Development of a novel connexin-based peptide for the treatment of corneal injury
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2012
    ..FirstString's lead novel bioengineered peptide dubbed ACT1, is based on the C-terminal sequence of connexin 43 (Cx43), and shows great promise in modulating intercellular communication...
  24. Electro-mechanical Resynchronization Therapy For Arrhythmogenic Right Ventricular
    Harikrishna Tandri; Fiscal Year: 2012
    ..Finally, insights gained from gap junctional protein expression in ARVC may stimulate research in the role of gap junctional proteins in arrhythmogenesis in other inherited cardiomyopathies. (End of Abstract) ..
  25. Mario Delmar; Fiscal Year: 2016
    ..Since its inception (in 1999), we focused on the mechanisms that regulate gap junctions formed by Connexin43 (Cx43)...
  26. X Edward Guo; Fiscal Year: 2014
    ..of 3D bovine trabecular bone explants with seeded primary bovine OBs depend on the gap junctions/hemi-channels connexin 43 (Cx43) in OCYs...
  27. Homeostatic Roles of Connexin43 in Response to DNA Damage
    DANNY SAM ROH; Fiscal Year: 2013
    ..in vitro model of CE cells, we have recently observed significant changes in the gap junction protein connexin-43 (Cx43) after exposure to DNA damage-inducing agents...
  28. Joseph P Stains; Fiscal Year: 2016
    ..The gap junction protein connexin 43, which permits the direct cell-to-cell communication of signals between osteoblasts and osteocytes, has been ..
  29. Andrew L Harris; Fiscal Year: 2016
    ..In connexin43 (Cx43), interactions between the cytoplasmic loop (CL) and the C-terminal domain (CT) is crucially involved physiological ..
  30. YURIY KUCHERYAVYKH; Fiscal Year: 2015
    ..Our preliminary data indicate that (1) PA eliminate cationic block of Cx43 gap junctions/hemichannels and (2) increase their open probability...
  31. Janis M Burt; Fiscal Year: 2014
    ..Three gap junction proteins are commonly expressed in vascular cells, connexin (Cx) 37, Cx40 and Cx43;in the endothelium Cx37 and Cx40 normally predominate, but during vasculogenesis and with stress, injury and ..
  32. Connexin acetylation: Impact on gap junction function and HDAC inhibitor respons
    JEANNETTE CHLOE BULINSKI; Fiscal Year: 2010
    ..1 kDa or less) between adjacent cells. In vertebrates the gap junctions comprised of the connexin, Cx43, perform vital functions in cardiac and other tissues...
  33. HEIDI GRABENSTATTER; Fiscal Year: 2015
    ..astrocytes3 suggests that increased open probability of gap- junction hemi channels via dephosphorylating of connexin 43 in hippocampal astrocytes may contribute to the progression of epileptogenesis...
  34. Structure and Dynamics of Gap Junction Channels
    MARK JAY YEAGER; Fiscal Year: 2013
    ..Previously, this research program focused on the 43 kDa connexin (Cx43) channel, which mediates ionic conduction between cardiac myocytes, thereby regulating the normal heartbeat, but ..
  35. Guy A Perkins; Fiscal Year: 2016
    ..3) To create electron tomographic volumes of genetically labeled Cx43 intercellular channels and cytoskeletal and scaffolding proteins in situ to better understand the cytoplasmic ..
  36. Internalization of gap junctions as a regulatory mechanism of direct GJIC
    Matthias M Falk; Fiscal Year: 2013
    ..b>Cx43-based gap junctional intercellular communication (GJIC) is of particular interest because it is regulated by both ..
  37. The effect of phthalates on the heart: molecular pathways and clinical relevance
    Nikki Gillum Posnack; Fiscal Year: 2013
    ..In contrast, little is known about the adverse effects of DEHP on the heart, and awareness of its potential cardiotoxicity is essentially non-existent. ..
  38. LYDIA ELEANOR MATESIC; Fiscal Year: 2014
    ..displays myocyte hypertrophy and disarray, disorganization of intercalated discs with altered localization of Connexin 43 (Cx43), and, usually, increased amounts of interstitial fibrosis...
  39. Hemal H Patel; Fiscal Year: 2016
    ..Two membrane structural proteins, caveolin-3 (Cav-3) and connexin43 (Cx43), exist in dynamic membrane microenvironments, and provide spatial organization to multi-protein complexes in lipid-..
  40. PROTEIN KINASE C IN THE LENS
    DOLORES JEAN TAKEMOTO; Fiscal Year: 2010
    ..previous work from this lab has shown that PKC3 is oxidatively activated and that this activation results in connexin 43 (Cx43), connexin 46 (Cx46), and connexin 50 (Cx50) gap junction inhibition...
  41. Osteoblastic lineage cells regulate osteoclastogenesis via Cx43 and gap junctions
    Yue Zhang; Fiscal Year: 2011
    ..The predominant form of connexin in bone cells is Cx43. Previous In vitro studies demonstrated that Cx43, hemichannel and GJ regulate osteoblast, osteocyte and osteoclast ..
  42. CONNEXONS IN CARDIOVASCULAR CELL COMMUNICATION
    Eric C Beyer; Fiscal Year: 2013
    ..Two major connexins (CX40 and CX43) are expressed in the atrium...
  43. Maiken Nedergaard; Fiscal Year: 2016
    ..It is well established that astrocytic hemichannels such as connexin-43 (Cx43) constitute an important pathway for gliotransmitter release...
  44. Miduturu Srinivas; Fiscal Year: 2014
    ..recently, we found that there are differences in the molecular permeability through channels made of Cx46, Cx50 and Cx43. In this proposal, we will continue to pursue electrophysiological studies to understand how the diversity in ..
  45. Regulation of Vascular Stabilization by Connexin 43
    Linda J Metheny-Barlow; Fiscal Year: 2013
    ..Our preliminary data demonstrate that the junctional molecule Connexin 43 (Cx43) plays a previously unidentified role in stabilization of normal blood vessels...
  46. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2013
    ..an enzyme (guanylyl cyclase), a calcium-activated potassium channel (SK3), and a component of the gap junction (connexin 43)...
  47. Samuel C Dudley; Fiscal Year: 2014
    ..factor NFkB via H2O2 production, c-Src is transcriptionally upregulated in our model, and ACE mice have reduced Cx43 protein in the absence of changes in mRNA abundance...
  48. ADAM CARL STRAUB; Fiscal Year: 2015
    ..nitric oxide group from a cysteine-thiol side chain, serves as an important post-translational modification on connexin 43 gap junction (GJ) proteins, and that this modification is associated with control of resistance arterial tone...
  49. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2012
    ..nitric oxide group from a cysteine-thiol side chain, serves as an important post-translational modification on connexin 43 gap junction (GJ) proteins, and that this modification is associated with control of resistance arterial tone...
  50. SMOOTH MUSCLE CELL PROLIFERATION IN HUMAN CORONARY ARTERY BYPASS GRAFTS
    Devendra K Agrawal; Fiscal Year: 2012
    ..We also found that increased connexin43 (Cx43) expression following stimulation of SMCs with angiotensin II (Ang II) and IGF-1 significantly increases ..
  51. Neetu Tyagi; Fiscal Year: 2016
    ..These studies will demonstrate the novel mechanism of cerebrovascular remodeling and have therapeutic ramifications for mitochondrial repair in cerebral ischemic stroke. ..
  52. MOLECULAR MECHANISMS OF THE MYOTONIC DYSTROPHY MUTATION
    MANI SUBRAMANIAM MAHADEVAN; Fiscal Year: 2013
    ..5, and profound disturbances in connexin 40 (Cx40) and connexin 43 (Cx43), proteins that are targets of Nkx2.5 and crucial for normal cardiac conduction...
  53. ASHLESH KRISHNA MURTHY; Fiscal Year: 2016
    ..b>Connexin 43, also expressed on oviduct epithelium, has been shown to be involved in the transfer of antigenic peptides from ..
  54. Determining the role of sema3d during fin regeneration
    MARY KATHRYN IOVINE; Fiscal Year: 2013
    ..alf dty86 also exhibit important and opposing differences in the expression of the gap junction gene connexin43 (cx43)...
  55. Xun Ai; Fiscal Year: 2015
    ..Recent studies showed an important role of JNK in downregulation of connexin43 (Cx43). Cx43 is one of the major atrial gap junctional proteins linked to AF stabilization and maintenance...
  56. Restoration of Skin Structure and Function Post-Wounding
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2010
    ..Ghatnekar are co inventors of novel bioengineered peptides based on a carboxyl-terminal fragment of connexin43 (Cx43)...
  57. Robert G Gourdie; Fiscal Year: 2016
    ..Remodeling of connexin43 (Cx43) GJs has been linked to cardiac arrhythmias...
  58. PIOTR J KRAJ; Fiscal Year: 2015
    ..This will be accomplished by modulating the expression of connexin 43, a molecule identified to control suppressor function of TR cells and expression of Foxp3...
  59. EMILY LYNN ONGSTAD; Fiscal Year: 2014
    ..We propose to investigate the mechanism by which the Connexin43 (Cx43) carboxyl terminal (CT) mimetic peptide [unreadable]CT1 modulates the wound healing response and promotes ..
  60. Malignant melanoma: Regulation by AP-2 and PAR-1
    MENASHE BARELI; Fiscal Year: 2012
    ..These genes include MCAM/MUC18, Connexin 43, Maspin, RUNX3, IL-8, Ang-2, GRO, ACRP30, and GITR-ligand...
  61. Heinz Josef Lenz; Fiscal Year: 2016
    ..the expression of Wnt/[unreadable]-catenin regulated genes including survivin, EGFR, VEGF, EphB2, S100A4,CD44, connexin 43 and cyclin D1, which play important roles in initiation, proliferation, angiogenesis, metastasis and drug ..
  62. Bisphosphonate binding to connexin43-expressing cells
    Teresita Bellido; Fiscal Year: 2007
    ..in vitro and in vivo, by a novel mechanism that involves the opening of hemichannels containing connexin43 (Cx43) (but not other connexins), with the subsequent activation of Src kinases, followed by activation of the ..
  63. Homogeneous Transfer of Connexin 43 to Prevent Atrial Fibrillation in Pigs
    Hao Qin; Fiscal Year: 2007
    ..We will test the hypothesis that overexpression of connexin 43 (Cx43) will increase conduction velocity through the atria in the absence of significant changes in tissue ..