cytochrome c oxidase subunit VIII

Summary

Gene Symbol: cytochrome c oxidase subunit VIII
Description: cytochrome c oxidase subunit 8A
Alias: COX, COX8, COX8-2, COX8L, VIII, VIII-L, cytochrome c oxidase subunit 8A, mitochondrial, cytochrome c oxidase polypeptide VIII-liver/heart, cytochrome c oxidase subunit 8-2, cytochrome c oxidase subunit 8A (ubiquitous), cytochrome c oxidase subunit VIII, cytochrome c oxidase subunit VIIIA (ubiquitous)
Species: human

Top Publications

  1. pmc Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture
    D Bishop Bailey
    Department of Applied Pharmacology, National Heart and Lung Institute, Imperial College of Science and Technology, London
    Br J Pharmacol 121:125-33. 1997
  2. ncbi [Venous thromboembolic pathology. New acquired risk factors or new data on acquired risk factors]
    L Drouet
    , , , 75010 Paris
    Arch Mal Coeur Vaiss 94:1318-26. 2001
  3. ncbi Diagnostic and management procedures for compensable back injuries without serious associated injuries. Modeling of the 1991 injury cohort from a major Michigan compensation insurer
    A Oleinick
    Department of Environmental and Industrial Health, School of Public, Health, University of Michigan, Ann Arbor, USA
    Spine (Phila Pa 1976) 23:93-110. 1998
  4. ncbi Angiogenic histogenesis of stromal cells in hemangioblastoma: ultrastructural and immunohistochemical study
    B Lach
    Department of Laboratory Medicine and Pathology, University of Ottawa, Canada
    Ultrastruct Pathol 23:299-310. 1999
  5. ncbi 5-year reoperation rates after different types of lumbar spine surgery
    A D Malter
    Department of Health Services, University of Washington, Seattle, USA
    Spine (Phila Pa 1976) 23:814-20. 1998
  6. ncbi Use of compact, porous units with immobilized ligands with high molecular masses in affinity chromatography and enzymatic conversion of substrates with high and low molecular masses
    D Josic
    Octapharma Pharmazeutika Produktionsges, mbH, Wien, Austria
    J Chromatogr A 803:61-71. 1998
  7. ncbi [Perinatal asphyxia, hypoxic-ischemic encephalopathy and neurological sequelae in full-term newborns. II. Description and interrelation]
    J Gonzalez de Dios
    Servicio de Pediatria, Hospital Universitario San Juan, Alicante
    Rev Neurol 24:969-76. 1996
  8. ncbi Additional categories of sleep-related eating disorders and the current status of treatment
    C H Schenck
    Minnesota Regional Sleep Disorders Center, Minneapolis 55415
    Sleep 16:457-66. 1993
  9. ncbi Effects of microgravity on osteoblast growth
    M Hughes-Fulford
    Laboratory of Cell Growth and Differentiation, Veteran's Administration Medical Center, San Francisco, CA, USA
    Gravit Space Biol Bull 11:51-60. 1998
  10. ncbi [Diagnosis and treatment of coagulation disorders]
    M M Esnaola Rojas
    , , Buenos Aires, Argentina
    Rev Neurol 29:1290-300. 1999

Research Grants

  1. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
  2. RAYMOND NELSON DUBOIS; Fiscal Year: 2016
  3. Community-Based Studies in Cancer and Environment
    Yi Li; Fiscal Year: 2011
  4. Jiu Chiuan Chen; Fiscal Year: 2014
  5. MEASUREMENT ERRORS IN CANCER EPIDEMIOLOGY
    DONNA L SPIEGELMAN; Fiscal Year: 2013
  6. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
  7. Mechanisms of Race-Based Differences in Factor VIII Immunogenicity in Hemophilia
    KATHLEEN PALMER PRATT; Fiscal Year: 2010
  8. Qizhen Shi; Fiscal Year: 2016
  9. Phase 2a Study of Ataluren in Hemophilia A and B (IND 104,321)
    JAY A BARTH; Fiscal Year: 2010
  10. Hematopoietic gene therapy for hemophilia A
    H Trent Spencer; Fiscal Year: 2013

Detail Information

Publications1521 found, 100 shown here

  1. pmc Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture
    D Bishop Bailey
    Department of Applied Pharmacology, National Heart and Lung Institute, Imperial College of Science and Technology, London
    Br J Pharmacol 121:125-33. 1997
    ..is normally catalysed in the endothelium by constitutive isoforms of NO synthase (eNOS) and cyclo-oxygenase (COX-1), respectively...
  2. ncbi [Venous thromboembolic pathology. New acquired risk factors or new data on acquired risk factors]
    L Drouet
    , , , 75010 Paris
    Arch Mal Coeur Vaiss 94:1318-26. 2001
    ..but, in addition to this factor which slightly increases the risk of venous thrombosis, increases of factor VIII independent of inflammatory conditions, of blood group and Von Willebrand factor, which all influence the level of ..
  3. ncbi Diagnostic and management procedures for compensable back injuries without serious associated injuries. Modeling of the 1991 injury cohort from a major Michigan compensation insurer
    A Oleinick
    Department of Environmental and Industrial Health, School of Public, Health, University of Michigan, Ann Arbor, USA
    Spine (Phila Pa 1976) 23:93-110. 1998
    ..Factors affecting use of medical care were identified by logistic regression, supplemented by Cox analysis for time to first procedure...
  4. ncbi Angiogenic histogenesis of stromal cells in hemangioblastoma: ultrastructural and immunohistochemical study
    B Lach
    Department of Laboratory Medicine and Pathology, University of Ottawa, Canada
    Ultrastruct Pathol 23:299-310. 1999
    ..immunoreactive for desmin, factor XIIIa, and Ricinus communis lectin receptors, and only occasionally for factor VIII and Ulex europeus lectin...
  5. ncbi 5-year reoperation rates after different types of lumbar spine surgery
    A D Malter
    Department of Health Services, University of Washington, Seattle, USA
    Spine (Phila Pa 1976) 23:814-20. 1998
    ..Adjusted rates were compared using logistic regression and proportional hazards (Cox) regression after controlling for age, gender, prior spine surgery, diagnosis, comorbidity, type of surgery, and ..
  6. ncbi Use of compact, porous units with immobilized ligands with high molecular masses in affinity chromatography and enzymatic conversion of substrates with high and low molecular masses
    D Josic
    Octapharma Pharmazeutika Produktionsges, mbH, Wien, Austria
    J Chromatogr A 803:61-71. 1998
    ..Experiments concerning the isolation of monoclonal antibodies against clotting factor VIII (FVIII) are carried out on disks, combining anion-exchange chromatography and protein A affinity chromatography as ..
  7. ncbi [Perinatal asphyxia, hypoxic-ischemic encephalopathy and neurological sequelae in full-term newborns. II. Description and interrelation]
    J Gonzalez de Dios
    Servicio de Pediatria, Hospital Universitario San Juan, Alicante
    Rev Neurol 24:969-76. 1996
    ..There have been several attempts to relate either perinatal asphyxia at birth or abnormal neurological findings after asphyxia in neonatal period (hypoxic-ischemic encephalopathy), to outcome...
  8. ncbi Additional categories of sleep-related eating disorders and the current status of treatment
    C H Schenck
    Minnesota Regional Sleep Disorders Center, Minneapolis 55415
    Sleep 16:457-66. 1993
    ..restless legs syndrome and sleep-related eating (n = 2); vii) anorexia nervosa with nocturnal bulimia (n = 2) and viii) amitriptyline treatment of migraines (n = 1)...
  9. ncbi Effects of microgravity on osteoblast growth
    M Hughes-Fulford
    Laboratory of Cell Growth and Differentiation, Veteran's Administration Medical Center, San Francisco, CA, USA
    Gravit Space Biol Bull 11:51-60. 1998
    ..The message of immediate early growth gene, cox-2 was decreased in the microgravity activated cells when compared to ground or 1-g flight controls...
  10. ncbi [Diagnosis and treatment of coagulation disorders]
    M M Esnaola Rojas
    , , Buenos Aires, Argentina
    Rev Neurol 29:1290-300. 1999
    ..such as deficits of factor VII and factor XIII, mutation of prothrombin 20210-->A, increase in factor VIII. Hyperfibrinogenemia and hyperhomocysteinemia are also independent risk factors for CVE...
  11. ncbi Testicular degeneration and spermatid retention in young male rats
    K P Lee
    DuPont Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delware 19714
    Toxicol Pathol 21:292-302. 1993
    ..decreased maturing spermatids (steps 15-19) and a slight depletion of round spermatids were observed in stages I-VIII. In severe testicular degeneration, seminiferous tubules were lined with 1-2 layers of round spermatids and ..
  12. ncbi The ankle-brachial index as a predictor of survival in patients with peripheral vascular disease
    M M McDermott
    Division of General Internal Medicine, Northwestern University Medical School, Chicago, Illinois
    J Gen Intern Med 9:445-9. 1994
    ..Kaplan-Meier and Cox proportional hazards analyses were used to determine the relationship between increasing lower-extremity ischemia, ..
  13. ncbi Immunohistochemical and electron microscopic profiles of cutaneous Kaposi's sarcoma and bacillary angiomatosis
    M Kostianovsky
    Department of Pathology and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Ultrastruct Pathol 16:629-40. 1992
    ..microscopy and by immunohistochemistry with monoclonal endothelial antibodies against CD34, BNH9, and factor VIII-related antigen as well as the lectins Ulex europaeus 1 and Psophocarpus tetragonolobus...
  14. pmc Regulation of prostaglandin production by nitric oxide; an in vivo analysis
    D Salvemini
    G D Searle, Department of Molecular Pharmacology, St Louis, MO 63167, USA
    Br J Pharmacol 114:1171-8. 1995
    ..Inducible cyclo-oxygenase (COX-2) and nitric oxide synthase (iNOS) expression accounted for the LPS-induced PG and NO release since the ..
  15. ncbi Overexpression of protein kinase C-zeta isoform increases cyclooxygenase-2 and inducible nitric oxide synthase
    B W Miller
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Physiol 273:C130-6. 1997
    Cyclooxygenase (COX) catalyzes the formation of prostaglandins from arachidonic acid. Nitric oxide synthase catalyzes the production of nitric oxide, a short-lived messenger molecule involved in many diverse cellular processes...
  16. ncbi Effect of natural ageing and antioxidant inhibition on liver antioxidant enzymes, glutathione system, peroxidation, and oxygen consumption in Rana perezi
    M Lopez-Torres
    Department of Animal Biology II, Faculty of Biology, Complutense University, Madrid, Spain
    J Comp Physiol B 160:655-61. 1991
    ..Cytochrome oxidase (COX), glutathione status, in vivo and in vitro liver peroxidation, and metabolic rate did not vary as a function of age...
  17. pmc Modulation by stereoselective inhibition of cyclo-oxygenase of electromechanical coupling in the guinea-pig isolated renal pelvis
    P Santicioli
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:1149-58. 1995
    1. The effects of the (S)- and (R)-enantiomers of the cyclo-oxygenase (COX) inhibitor, ketoprofen, have been investigated on the spontaneous activity of the guinea-pig isolated renal pelvis and on electrical field stimulation-(EFS) ..
  18. ncbi Protein adsorption to poly(ether urethane ureas) modified with acrylate and methacrylate polymer and copolymer additives
    M R Brunstedt
    Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio 44106
    J Biomed Mater Res 27:367-77. 1993
    ..and whole or diluted human plasma were used to characterize the presence of fibrinogen, immunoglobulin G, factor VIII/von Willebrand factor, Hageman factor (factor XII), and albumin on a PEUU formulation and on PEUU formulations ..
  19. ncbi Predicting cutaneous hypersensitivity reactions to cotrimoxazole in HIV-infected individuals receiving primary Pneumocystis carinii pneumonia prophylaxis
    S Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6095, USA
    J Gen Intern Med 10:380-6. 1995
    ..b>Cox regression was used to calculate relative rates (RRs) and 95% confidence intervals (CIs) for a number of clinical ..
  20. ncbi Molecular systematics of the nepetoideae (family Labiatae): phylogenetic implications from rbcL gene sequences
    M Kaufmann
    , , Bundesrepublik Deutschland
    Z Naturforsch C 49:635-45. 1994
    ..II-Lavandula, III-Agastache, Glechoma, IV-Satureja, Hyssopus, Dracocephalum, V-Nepeta, VI-Hormium, VII-Prunella, VIII-Melissa, Ocimum, IX-Monarda, Mentha, X-Origanum, Thymus, XI-Salvia, XII-Rosmarinus, and XIII-Perovskia...
  21. ncbi Effects of deamino-8-D-arginin vasopressin on blood loss and coagulation factors in scoliosis surgery. A double-blind randomized clinical trial
    A Alanay
    Department of Orthopaedics and Traumatology, Hacettepe University, Ankara, Turkey
    Spine (Phila Pa 1976) 24:877-82. 1999
    ..05). Only factor VIII:C levels exhibited significant elevations at 30 minutes and at 24 hours (P < 0.05)...
  22. ncbi Regulation of mitochondrial biogenesis in Saccharomyces cerevisiae. Intricate interplay between general and specific transcription factors in the promoter of the QCR8 gene
    J H de Winde
    Section for Molecular Biology, Institute for Molecular Cell Biology, BioCentrum Amsterdam, The Netherlands
    Eur J Biochem 233:200-8. 1995
    Transcription of the QCR8 gene, encoding subunit VIII of the Saccharomyces cerevisiae mitochondrial ubiquinol-cytochrome c oxidoreductase (QCR), is controlled by the carbon-source-dependent heme-activator protein complex HAP2/3/4 and the ..
  23. ncbi [Risk factors predictive of neurological sequelae in term newborn infants with perinatal asphyxia]
    J Gonzalez de Dios
    Departamento de Pediatria, Hospital Universitario San Juan, Espana
    Rev Neurol 32:210-6. 2001
    ..The objective of this study is to analyze the perinatal risk factors of neurologic sequelae in asphyctic term newborns...
  24. ncbi Radical surgery and postoperative split-course radiotherapy in squamous cell carcinoma of the head and neck--factors influencing local control and survival
    M J Kajanti
    Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland
    Acta Oncol 32:319-25. 1993
    ..T- and N-category and pretreatment Karnofsky index had the strongest association with local control, whereas in Cox's proportional hazard's regression analyses T-category and pretreatment Karnofsky had the strongest association ..
  25. pmc Delays in protease inhibitor use in clinical practice
    K M Fairfield
    Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Mass. 02215, USA
    J Gen Intern Med 14:395-401. 1999
    ..In Cox proportional hazards modeling, significant univariate correlates for delayed protease inhibitor initiation were ..
  26. ncbi Angiogenic process in bacillary angiomatosis
    M Kostianovsky
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania
    Ultrastruct Pathol 18:349-55. 1994
    ..the lesions, including the spindle cell areas, expressed all endothelial markers used; CD34, factor VIII-related antigen, and Ulex europaeus 1 were the most consistent in intensity, however...
  27. ncbi Idiopathic intracranial hypertension and hemophilia A
    D E Jacome
    Department of Medicine, Franklin Medical Center, Greenfield, Mass, USA
    Headache 41:595-8. 2001
    ..BACKGROUND: Hemophilia A is a rare inherited coagulation disorder secondary to factor VIII deficiency...
  28. ncbi [Blood vessels in normal and abnormal mitral valve leaflets]
    T I-Ida
    Department of Pathology, Nippon Medical Shool, Tokyo, Japan
    J Nippon Med Sch 68:171-80. 2001
    ..vessels was counted at the surgical excision line of the valvular rings by immunohistochemical study using Factor VIII related antigen and CD34...
  29. pmc Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy
    A Tomlinson
    Department of Experimental Pathology, William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 113:693-8. 1994
    1. The profiles of cyclo-oxygenase (COX) and nitric oxide synthase (NOS) isoforms were determined in the rat carrageenin-induced pleurisy model of acute inflammation. 2...
  30. ncbi Claim rates of compensable back injuries by age, gender, occupation, and industry. Do they relate to return-to-work experience?
    J V Gluck
    Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, USA
    Spine (Phila Pa 1976) 23:1572-87. 1998
    ..A retrospective cohort study of Michigan workers' compensation cases involving back injuries in 1986 and 1987 with incidence and outcome data...
  31. ncbi [Hypertrophic pachymeningitis. A review of the histories of two cases and pathological relationship with the Tolosa-Hunt syndrome and the orbital pseudotumor]
    J Bosch
    Hospital de Barcelona, Barcelona,
    Rev Neurol 31:946-51. 2000
    ..hypoacusia for the past six months, progressively accompanied by ipsilateral paralysis of the II, IV, VI, VII and VIII cranial nerves but with no other alterations on physical examination...
  32. pmc Spontaneous spinal subdural hematoma in a young adult with hemophilia
    R Y Friday
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA, USA
    J Natl Med Assoc 91:289-94. 1999
    ..Following correction of factor VIII levels, surgical exploration was undertaken and demonstrated liquefied blood within the subdural space without ..
  33. pmc Health disparity in black women: lack of pharmaceutical advertising in black vs. white-oriented magazines
    S C Omonuwa
    Morehouse School of Medicine, Department of Family Medicine, Atlanta, GA 30331 2099, USA
    J Natl Med Assoc 93:263-6. 2001
    ..magazines and not the black-oriented magazines were, for example, cholinesterase inhibitors, calcium supplements, COX II-inhibitors, intranasal steroids, anorexiants, proton pump inhibitors, and smoking deterrent agents...
  34. ncbi Ovarian myxoma: ultrastructural and immunohistochemical findings
    M J Costa
    Department of Pathology, Grady Memorial Hospital, Emory University, School of Medicine, Atlanta, Georgia 30335 3801
    Ultrastruct Pathol 16:429-38. 1992
    ..neoplastic cells showed no immunoreactivity with antibodies to desmin, S-100 protein, cytokeratin AE1:AE3, factor VIII-related protein, or placental alkaline phosphatase...
  35. ncbi [Relationship between tissue inhibitors of metalloproteinase and metastasis and prognosis in breast cancer]
    X Jiang
    Department of Surgery, College of Clinical Oncology, Beijing Medical University, China
    Zhonghua Wai Ke Za Zhi 38:291-3, 19. 2000
    ..To investigate the clinical significance of tissue inhibitors of metalloproteinase (TIMP) -3 and TIMP-4 in human breast cancer...
  36. pmc Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids
    T A Swierkosz
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1335-42. 1995
    1. Lipopolysaccharide (LPS) co-induces nitric oxide synthase (iNOS) and cyclo-oxygenase (COX-2) in J774.2 macrophages. Here we have used LPS-activated J774...
  37. ncbi Proposal of reference values for home blood pressure measurement: prognostic criteria based on a prospective observation of the general population in Ohasama, Japan
    I Tsuji
    Department of Public Health, Tohoku University School of Medicine, Sendai, Japan
    Am J Hypertens 10:409-18. 1997
    ..The association between baseline BP values and the overall mortality was examined by Cox proportional hazards regression model, adjusted for age, gender, and the use of antihypertensive medication...
  38. ncbi Survey of cases of familial mental illness. L. S. Penrose, July 1945
    L S Penrose
    Division of Psychiatric Research, Ontario Department of Health
    Eur Arch Psychiatry Clin Neurosci 240:315-24; discussion 314-5. 1991
    ..vii) Each main diagnosis group has its characteristic first admission age. (viii) The first admission age is earlier in males than in females for schizophrenics, and later in males than in females ..
  39. ncbi Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation
    T Nakajima
    Division of Environmental Health Research, Osaka Prefectural Institute of Public Health, 69 3, 1 chome, 537 0025, Osaka, Japan
    Int J Biochem Cell Biol 32:779-87. 2000
    ..for G-protein; H-7 for protein kinase C (PKC); AA861 for 5-lipoxygenase (5-LO); indomethacin for cyclo-oxygenase (COX); ETYA for both 5-LO and COX; hexanolamine PAF for platelet-activating factor (PAF)...
  40. ncbi Long-term survival and prognostic factors for 2170 breast cancer patients treated at two cancer centers (Milan and Houston)
    N Cascinelli
    Division of Surgical Oncology B, National Cancer Institute, Milan, Italy
    Tumori 75:123-31. 1989
    ..The latter group was defined "unknown". Multivariate analysis of survival, carried out by means of Cox's regression model, showed that mortality of these patients for all causes was significantly affected by the ..
  41. ncbi Influence of orchidectomy and ovariectomy on the blood-brain barrier permeability during bicuculline-induced seizures
    B Oztas
    Department of Physiology, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey
    Horm Metab Res 30:500-3. 1998
    ..V: ovariectomized female; Group VI: orchidectomized male; Group VII: ovariectomized female + bicuculline; Group VIII: orchidectomized male + bicuculline (1.2 mg/kg, i.v...
  42. pmc Three case definitions of malaria and their effect on diagnosis, treatment and surveillance in Cox's Bazar district, Bangladesh
    R M Montanari
    WHO Dhaka, Bangladesh
    Bull World Health Organ 79:648-56. 2001
    ..MCDs) were developed, with treatment and reporting guidelines, and used in all static health facilities of Cox's Bazar district, Bangladesh (population 1.5 million)...
  43. ncbi Transfusion medicine management for reconstructive spinal repair in a patient with von Willebrand's disease and a history of heavy surgical bleeding
    C D Bolan
    Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Spine (Phila Pa 1976) 26:E552-6. 2001
    ..and assessment of hemostasis and transfusion medicine management, including administration of Humate P, a Factor VIII preparation with high von Willebrand factor content...
  44. ncbi Timing of referral of terminally ill patients to an outpatient hospice
    N A Christakis
    Leonard Davis Institute of Health Economics, Department of Sociology, University of Pennsylvania, Philadelphia
    J Gen Intern Med 9:314-20. 1994
    ..METHODS: A retrospective cohort of 405 hospice outpatients was analyzed with Cox regression to evaluate the effect on length of stay of patient age, gender, race, diagnosis, activity level, mental ..
  45. ncbi [The importance of lung function as a predictor of 2-year mortality in mucoviscidosis]
    H Grasemann

    Pneumologie 49:466-9. 1995
    ..19 of the 73 patients included in this analysis had died. Cox proportional hazard regression analysis was performed using the lung function parameters as single covariates...
  46. pmc Modulation by nitric oxide of prostaglandin biosynthesis in the rat
    L Sautebin
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Br J Pharmacol 114:323-8. 1995
    ..3': 5'-cyclic monophosphate (cyclic GMP)-independent mechanism and suggest that the interaction between NO synthase and cyclo-oxygenase (COX) pathways may represent an important mechanism for the modulation of the inflammatory response.
  47. ncbi Protein adsorption onto poly(ether urethane ureas) containing Methacrol 2138F: a surface-active amphiphilic additive
    M R Brunstedt
    Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio 44106
    J Biomed Mater Res 27:255-67. 1993
    ..human plasma were also used to characterize the presence of the proteins fibrinogen, immunoglobulin G, factor VIII/von Willebrand factor, Hageman factor (factor XII), and albumin, on the surface of the same PEUUs as analyzed by ..
  48. ncbi The influence of indemnification by workers' compensation insurance on recovery from acute backache. North Carolina Back Pain Project
    N M Hadler
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Spine (Phila Pa 1976) 20:2710-5. 1995
    ..02). Recovery of the sense of wellness they enjoyed before this episode of back pain was delayed (Cox Model: Hazard Ratio = 0.822; P < 0.001; confidence interval: 0.733, 0...
  49. ncbi Interspecies differences in renal localization of cyclooxygenase isoforms: implications in nonsteroidal antiinflammatory drug-related nephrotoxicity
    K N Khan
    Department of Product Safety Assessment, G D Searle and Company, Skokie, Illinois 60077, USA
    Toxicol Pathol 26:612-20. 1998
    Cyclooxygenase (COX) exists in 2 related but unique isoforms: one is constitutive (COX-1) and functions in normal cell physiology, and the other is inducible (COX-2) and is expressed in response to inflammatory stimuli...
  50. ncbi Joint 1994 Wolff Award Presentation. Migraine and major depression: a longitudinal study
    N Breslau
    Department of Psychiatry, Henry Ford Health Sciences Center, Detroit, MI 48202-2689
    Headache 34:387-93. 1994
    ..5 year follow-up interval (in the 1992 interview). Using Cox-proportional hazards models with time-dependent covariates, we estimated the relative risk for major depression ..
  51. ncbi Mortality from skin melanoma in Italy and Friuli-Venezia Giulia region, 1970-1989
    S Franceschi
    Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano (Pordenone, Italy
    Tumori 80:251-6. 1994
    ..order to assess the trends of CMM, analysis of the specific code for CMM (International Classification of Disease VIII and IX:172) was coupled with analysis of total skin cancer mortality rates, standardized on the 1981 Italian Census ..
  52. ncbi The P(174)L mutation in the human hSCO1 gene affects the assembly of cytochrome c oxidase
    C Paret
    Institute of Genetics, University of Technology Dresden, Mommsenstrasse 13, Dresden, D 01062, Germany
    Biochem Biophys Res Commun 279:341-7. 2000
    Mutations of the yeast SCO1 gene result in impaired COX assembly...
  53. ncbi Amianthoid myofibroblastoma of the soft tissues
    A Corsi
    Dipartimento di Medicina Sperimentale e Patologia, , Roma, Italy
    Tumori 83:862-7. 1997
    ..actin and, focally, for desmin; immunostaining for cytokeratin, epithelial membrane antigen, S-100 protein, factor VIII-related antigen, and CD34 was negative...
  54. ncbi The prognosis of low back pain in general practice
    H J van den Hoogen
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 22:1515-21. 1997
    ..indicators, the duration of the index episode, and the occurrence of a relapse were analyzed using multivariate Cox regression and logistic regression analysis, respectively...
  55. ncbi Prognostic factors and results of radiation therapy in optic pathway tumors
    C A Regueiro
    Department of Radiation Oncology, , Madrid, Spain
    Tumori 82:353-9. 1996
    ..were calculated using the Kaplan-Meier method and differences between curves were evaluated by the Mantel-Cox test...
  56. ncbi [Analysis of utility of the phenotyping method on detection of cases infected by multiple strains of methicillin-resistant Staphylococcus aureus (MRSA)]
    T Sawai
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Kansenshogaku Zasshi 72:1035-40. 1998
    ..Phenotyping of all 113 MRSA isolates were done by coagulase typing (I-VIII), production of enterotoxins (SEA-SED) and toxic shock syndrome toxin-1 (TSST-1), hemolysis typing and antibiogram (..
  57. ncbi Non-Hodgkin's lymphomas of the tonsil: a retrospective analysis of twenty-eight patients with primary tonsillary lymphoma
    I Barista
    Department of Medical Oncology, Hacettepe University, Ankara, Turkey
    Tumori 81:234-7. 1995
    ..To analyze the clinical and therapeutic aspects of patients with primary tonsillary non-Hodgkin's lymphoma...
  58. pmc Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
    D Riendeau
    Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Br J Pharmacol 121:105-17. 1997
    ..one) was identified as a novel orally active and highly selective cyclo-oxygenase-2 (COX-2) inhibitor. 2...
  59. ncbi A comparison of the effects of etodolac and ibuprofen on renal haemodynamics, tubular function, renin, vasopressin and urinary excretion of albumin and alpha-glutathione-S-transferase in healthy subjects: a placebo-controlled cross-over study
    K B Svendsen
    Eur J Clin Pharmacol 56:383-8. 2000
    ..Cyclo-oxygenase exists in two isoforms (COX-1 and COX-2)...
  60. pmc Cytokine-mediated induction of cyclo-oxygenase-2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide
    P Akarasereenont
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 115:401-8. 1995
    1. The induction of cyclo-oxygenase-2 (COX-2) afforded by bacterial lipopolysaccharide (LPS, endotoxin) in bovine aortic endothelial cells (BAEC) is mediated by tyrosine kinase...
  61. ncbi Interleukin 1-induced cyclooxygenase and nitric oxide synthase gene expression in the rat dorsal root ganglia is modulated by antioxidants
    O J Igwe
    University of Missouri Kansas City, School of Pharmacy, Division of Pharmacology, M3 103, Medical School Building, 2411 Holmes Street, Kansas City, MO 64108 2792, USA
    Neuroscience 105:971-85. 2001
    Interleukin 1beta induced both nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2) gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities, and corresponding increases in the production ..
  62. ncbi Anti-inflammatory drugs in the 21st century
    K D Rainsford
    Biomedical Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Howard Street, Sheffield, SI 1WB, UK
    Subcell Biochem 42:3-27. 2007
    ..discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that ..
  63. pmc The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity
    B Zingarelli
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Br J Pharmacol 120:357-66. 1997
    ..inflammatory conditions, in which both the inducible isoforms of nitric oxide synthase (iNOS) and cyclo-oxygenase (COX-2) are induced, inhibition of NOS also results in inhibition of arachidonic acid metabolism...
  64. doi Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side effects after major surgery: a systematic review
    C McDaid
    Centre for Reviews and Dissemination, University of York, York, UK
    Health Technol Assess 14:1-153, iii-iv. 2010
    To determine which class of non-opioid analgesics - paracetamol (acetaminophen), NSAIDs or COX-2 inhibitors - is the most effective at reducing morphine consumption and associated adverse effects when used as part of multimodal analgesia ..
  65. pmc Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin
    Lacy A Holowatz
    Department of Kinesiology, The Pennsylvania State University, Noll Laboratory, University Park, Pennsylvania, USA
    J Appl Physiol (1985) 107:1121-7. 2009
    In young healthy humans full expression of reflex cutaneous vasodilation is dependent on cyclooxygenase (COX)- and nitric oxide synthase (NOS)-dependent mechanisms...
  66. ncbi Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells
    Jeanette A Richards
    Ohio State Biochemistry Program, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    J Steroid Biochem Mol Biol 80:203-12. 2002
    ..our recent studies have shown a strong linear association between CYP19 expression and the sum of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) expression in breast cancer specimens...
  67. ncbi Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis
    Trevor Duffy
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Eire
    Drugs 63:31-6. 2003
    Cyclo-oxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is responsible for homeostatic functions, whereas COX-2 is inducible and responsible for the inflammatory effects of prostaglandins...
  68. ncbi Therapeutic potential of selective cyclooxygenase-2 inhibitors in the management of tumor angiogenesis
    Stephen Gately
    NeoPharm Inc, Department of Translational Medicine, Lake Forest, Ill, USA
    Prog Exp Tumor Res 37:179-92. 2003
    It is clear that COX-2 plays an important role in tumor and endothelial cell biology. Increased expression of COX-2 occurs in multiple cells within the tumor microenvironment that can impact on angiogenesis...
  69. pmc Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells
    Tongzheng Liu
    Division of Pharmacology, The Ohio State University College of Pharmacy, and The Dorothy M, Davis Heart and Lung Research Institute, Columbus, Ohio 43210, USA
    J Inflamm (Lond) 6:20. 2009
    ..Degradation of iNOS was reduced by a calpain inhibitor, suggesting that PIN1 may affect induction of other calpain-sensitive inflammatory proteins, such as cyclooxygenase (COX)-2, in MAEC.
  70. ncbi Implication of gastrin in cyclooxygenase-2 expression in Helicobacter pylori infected gastric ulceration
    S J Konturek
    Department of Physiology, Jagiellonian University School of Medicine, Cracow, Poland
    Prostaglandins Other Lipid Mediat 66:39-51. 2001
    ..undertaken to assess the relationship between the HP infection and coexpression of gastrin and cyclooxygenases (COX), the rate limiting enzymes in the PG production...
  71. ncbi Development of freeze-dried albumin-free formulation of recombinant factor VIII SQ
    T Osterberg
    Department of Pharmaceutical Technology, Pharmacia and Upjohn AB, Stockholm, Sweden
    Pharm Res 14:892-8. 1997
    To develop a stable freeze-dried formulation of recombinant factor VIII-SQ (r-VIII SQ) without the addition of albumin.
  72. ncbi Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids
    I Chakraborty
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    J Mol Endocrinol 16:107-22. 1996
    Cyclo-oxygenase (COX) is a rate-limiting enzyme that converts arachidonic acid to prostaglandins (PGs) and exists in two isoforms, COX-1 and COX-2...
  73. ncbi Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies
    H Tapiero
    UNIVERSITE DE PARIS, Faculté de Pharmacie CNRS UMR 8612, Chatenay Malabry, France
    Biomed Pharmacother 56:215-22. 2002
    ..a source of AA or compounds which can be converted into AA, synthesis of prostaglandins (PGs) by a cyclooxygenase (COX) enzyme would be compromised, and this would seriously affect many normal metabolic processes...
  74. ncbi Cloning of guinea pig cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase complementary deoxyribonucleic acids: steroid-modulated gene expression correlates to prostaglandin F2 alpha secretion in cultured endometrial cells
    K E Bracken
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Endocrinology 138:237-47. 1997
    ..We cloned guinea pig cDNAs for cyclooxygenase 2 (COX-2), 15-hydroxyprostaglandin dehydrogenase (PGDH) that converts PGF2 alpha to biologically inactive 13,14-dihydro-15-..
  75. ncbi Role of cyclooxygenase isoforms in gastric mucosal defence
    B M Peskar
    Department of Experimental Clinical Medicine, University of Bochum, D 44780 Bochum, Germany
    J Physiol Paris 95:3-9. 2001
    ..Prostaglandin biosynthesis is catalysed by the enzyme cyclooxygenase (COX), which exists in two isoforms, COX-1 and COX-2...
  76. ncbi Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosis
    C Max Schmidt
    Department of Surgery and The Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Gastrointest Surg 7:1024-33. 2003
    Cyclooxygenase-2 (COX-2) and ERK-MAPK mitogenic signaling pathways are important in human hepatocellular carcinoma...
  77. ncbi Cyclo-oxygenase-2 inhibitors: when should they be used in the elderly?
    Ruth Savage
    New Zealand Pharmacovigilance Centre, Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
    Drugs Aging 22:185-200. 2005
    ..The cyclo-oxygenase (COX)-2 inhibitors are as effective as standard NSAIDs for the relief of pain and for improving function in elderly ..
  78. ncbi Collagen type VIII expression in human diabetic nephropathy
    J Gerth
    University of Jena, Jena, Germany
    Eur J Clin Invest 37:767-73. 2007
    Collagen type VIII is a non-fibrillar short-chain collagen that may modulate migration, proliferation and adherence of various cells. Only very sparse information exists on collagen type VIII expression in human diabetic nephropathy.
  79. ncbi Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor
    G Lal
    Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 61:6131-6. 2001
    ..This is believed to be mediated, at least in part, by inhibition of cyclooxygenase (COX) activity. There are two COX isoenzymes, namely the constitutively expressed COX-1 and the inducible COX-2...
  80. ncbi Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers
    B Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock, Germany
    Int J Clin Pharmacol Ther 46:180-6. 2008
    Over the last few years, there has been concern regarding the cardiovascular safety of selective cyclooxygenase (COX)-2 inhibitors and high-dose regimens of nonsteroidal anti-inflammatory drugs (NSAIDs)...
  81. doi Relationship between cyclooxygenase-2 and human epidermal growth factor receptor 2 in vascular endothelial growth factor C up-regulation and lymphangiogenesis in human breast cancer
    Rabindra N Bhattacharjee
    Department of Anatomy, The University of Western Ontario, London, Ontario, Canada
    Cancer Sci 101:2026-32. 2010
    Both cyclooxygenase (COX)-2 and human epidermal growth factor receptor (HER)-2 promote breast cancer progression; however, the relationship between the two molecules remains unclear...
  82. pmc Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma
    Hong Ling Li
    Department of Hematology, Xijing Hospital, Fourth Military Medical University, 127 ChangLe West Road, Xi an 710032, Shaanxi Province, China
    World J Gastroenterol 10:1862-6. 2004
    To assess the expression of cyclooxygenase-2 (COX-2), nitric oxide synthase (iNOS), p53 and Ki-67 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and clarify the relationship between COX-2 expression and iNOS or p53 ..
  83. ncbi Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation
    M Gomez Lira
    Department of Mother and Child, Section of Biology and Genetics, University of Verona, Verona, Italy
    Br J Dermatol 157:49-57. 2007
    Overexpression of cyclooxygenase-2 (COX-2), resulting in excessive prostaglandin production, has been observed in human epidermal keratinocytes after ultraviolet B injury, in squamous cell skin carcinoma (SCC), in actinic keratoses, and ..
  84. ncbi Withdrawal of COX-2 selective inhibitors rofecoxib and valdecoxib: impact on NSAID and gastroprotective drug prescribing and utilization
    Shawn X Sun
    Walgreens Health Services, Deerfield, IL 60015, USA
    Curr Med Res Opin 23:1859-66. 2007
    Cyclo-oxygenase-2 (COX-2) inhibitors rofecoxib and valdecoxib were withdrawn from the market because of their association with cardiovascular problems...
  85. ncbi Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks
    Edgar M Moran
    Department of Medicine, University of California, Irvine, USA
    J Environ Pathol Toxicol Oncol 21:193-201. 2002
    ..This is chiefly due to the inhibition of the cyclooxygenase (COX) enzymes...
  86. pmc Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue
    Rikke Nørregaard
    Deptartment of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    Am J Physiol Regul Integr Comp Physiol 298:R1017-25. 2010
    Inhibitors of cyclooxygenase (COX)-2 prevent suppression of aquaporin-2 and reduce polyuria in the acute phase after release of bilateral ureteral obstruction (BUO)...
  87. pmc Selective COX-2 inhibitors, NSAIDs and congestive heart failure: differences between new and recurrent cases
    Patricia McGettigan
    Discipline of Clinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia
    Br J Clin Pharmacol 65:927-34. 2008
    ..shown that in susceptible individuals, nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors increase the risk of developing congestive heart failure (CHF)...
  88. ncbi Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction
    Nicole Scheuren
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    J Mol Cell Cardiol 34:29-37. 2002
    ..Cyclooxygenase-2 (COX-2) plays a key role in mediating inflammation...
  89. ncbi Cyclooxygenase-2 directly regulates gene expression of P450 Cyp19 aromatase promoter regions pII, pI.3 and pI.7 and estradiol production in human breast tumor cells
    Jenifer R Prosperi
    Department of Molecular Virology, Immunology, and Medical Genetics, The Integrated Biomedical Science Graduate Program, The Ohio State University College of Medicine, 2184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    Prostaglandins Other Lipid Mediat 81:55-70. 2006
    The present studies evaluated the direct effects of the presence of human cyclooxygenase-2 (Cox-2) on gene expression of specific promoter regions of the P450 Cyp19 enzyme aromatase enzyme and its product, estradiol, in Cox-2 null ..
  90. ncbi Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation
    Y F Chen
    Department of Public Health and Epidemiology, University of Birmingham, UK
    Health Technol Assess 12:1-278, iii. 2008
    To review the clinical effectiveness and cost-effectiveness of cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drugs (NSAIDs) (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for ..
  91. doi Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale
    Muhammad Amer
    Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Cardiol Rev 18:204-12. 2010
    Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit production of prostaglandins by acting on cyclooxygenase (COX) isoenzymes 1 and 2. Nonselective NSAIDs inhibit both COX 1 and 2 isoenzymes (eg, ibuprofen and naproxen)...
  92. ncbi Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivity
    Laura D Carbone
    Department of Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA
    J Bone Miner Res 18:1795-802. 2003
    BMD was examined in users of NSAIDs (by COX selectivity) and aspirin in the Health ABC cohort (n = 2853). Significantly higher BMD was found in users of relative COX-2 selective NSAIDs with aspirin (COX-2/ASA) compared with nonusers...
  93. ncbi Dual acting anti-inflammatory drugs: a reappraisal
    A Bertolini
    Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, via G Campi 287, 41100 Modena, Italy
    Pharmacol Res 44:437-50. 2001
    ..approach seemed to be the preparation of novel NSAIDs, targeted at the inducible isoform of prostaglandin synthase (COX-2); they appear to be devoid of gastrointestinal toxicity, in that they spare mucosal prostaglandin synthesis...
  94. ncbi Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpression
    Karin Muller-Decker
    Section of Eicosanoids and Epithelial Tumor Development, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 121:661-8. 2003
    Cyclooxygenase (COX)-1 and -2 catalyze the key reaction in prostaglandin biosynthesis...
  95. ncbi Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients
    Ang Yuan
    Division of Chest Medicine, Departments of Internal Medicine and Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cancer 115:545-55. 2005
    ..Our aim was to study total COX-2 mRNA expression in both cancer cells and surrounding stromal cells and its association with angiogenic factor ..
  96. pmc Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma
    Ying Hui Zhi
    Department of General Surgery, Affiliated Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China
    World J Gastroenterol 11:3724-8. 2005
    To investigate the relationships between the expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) and the degree of vascularization, clinicopathologic feature, survival time of patients with gallbladder ..
  97. ncbi Correlation between expression of cyclooxygenase-2 and the presence of CD4+ infiltrating T-lymphocyte in human primary hepatocellular carcinoma
    Ya Wei Gao
    Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, PR China
    Hepatogastroenterology 55:345-50. 2008
    Recent studies have found that Cyclooxygenase-2(Cox-2) is frequently inappropriately expressed in primary hepatocellular carcinoma (HCC), suggesting that abnormal Cox-2 expression plays an important role in hepatocarcinogenesis...
  98. doi Cyclooxygenase-2 protects germ cells against spermatogenesis disturbance in experimental cryptorchidism model mice
    Hiroki Kubota
    Department of Nephrourology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Androl 32:77-85. 2011
    The role of cyclooxygenases (COX) in the male reproductive organ remains unclear. However, there are some reports suggesting that COX-2 might have an effect on spermatogenesis or steroidogenesis...
  99. ncbi Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum
    E Beubler
    Department of Experimental and Clinical Pharmacology, Karl Franzens University of Graz, Graz, Austria
    J Pharmacol Exp Ther 297:940-5. 2001
    ..To elucidate the role of the different isoforms (COX-1 and COX-2) of cyclooxygenase in cholera toxin (CT)-induced fluid secretion and intraluminal prostaglandin E(2) (..
  100. ncbi Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: critical remarks
    A Bertolini
    Section of Clinical Pharmacology and Toxicology, Department of Medicine, University of Modena and Reggio Emilia, Largo del Pozzo 71, Modena, 41100, Italy
    Curr Med Chem 9:1033-43. 2002
    ..approach seemed to be the preparation of novel NSAIDs, specific for the inducible isoform of cyclooxygenase (COX-2): they appear to be devoid of gastrointestinal toxicity, in that they spare mucosal prostaglandin synthesis...

Research Grants133 found, 100 shown here

  1. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
    ..New versions of these drugs (coxibs) act by inhibiting the activity of the cyclooxygenase (COX)-2 enzyme...
  2. RAYMOND NELSON DUBOIS; Fiscal Year: 2016
    ..prostaglandin E2 (PGE2) in carcinogenesis, a cutting-edge goal of chemoprevention research is to find alternative COX-2-independent approaches to suppress PGE2 production or to block the downstream procarcinogenic effects of this ..
  3. Community-Based Studies in Cancer and Environment
    Yi Li; Fiscal Year: 2011
    ..Specifically, the PI plans to develop: (1) Semiparametric normal transformation Cox models for multivariate survival data: Flexible modeling of pairwise dependence will be developed and new class of ..
  4. Jiu Chiuan Chen; Fiscal Year: 2014
    ..S. EPA monitoring system with the data outputs of air quality models. Multivariable-adjusted Cox models, multilevel mixed-effect models, and latent curve structural models will be used to analyze the data...
  5. MEASUREMENT ERRORS IN CANCER EPIDEMIOLOGY
    DONNA L SPIEGELMAN; Fiscal Year: 2013
    ..Here, the dependent variable is time to cancer incidence or mortality;thus, Cox models are considered in which time-varying covariates such as cumulative averages and cumulative exposures are of ..
  6. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Factor VIII (fVIII) and factor IX (fIX) are two key plasma proteins that are deficient in the bleeding disorders Hemophilia A and Hemophilia B, respectively...
  7. Mechanisms of Race-Based Differences in Factor VIII Immunogenicity in Hemophilia
    KATHLEEN PALMER PRATT; Fiscal Year: 2010
    ..provided by applicant): The proposed study will elucidate mechanisms of immune responses to the infused factor VIII (FVIII) used to arrest bleeding in hemophilia A (HA) patients, in which ~25% of patients develop "inhibitors" (..
  8. Qizhen Shi; Fiscal Year: 2016
    ..the most common severe bleeding disorder resulting from hereditary deficiency of the blood clotting protein, factor VIII (FVIII)...
  9. Phase 2a Study of Ataluren in Hemophilia A and B (IND 104,321)
    JAY A BARTH; Fiscal Year: 2010
    ..90 power whether PTC124 provides pharmacological effect in HA/HB as measured by plasma clotting factor VIII (FVIII)/FIX activity...
  10. Hematopoietic gene therapy for hemophilia A
    H Trent Spencer; Fiscal Year: 2013
    ..Hemophilia A is a congenital bleeding disorder caused by genetic mutations affecting a plasma protein, termed factor VIII (fVIII), whose function is to facilitate blood clotting...
  11. Therapeutic-Expression of a Platelet-Specific Integrin
    DAVID ALLEN WILCOX; Fiscal Year: 2010
    ..used to explore strategies to correct canine Hemophilia A via targeted synthesis and storage of coagulation factor VIII to platelet a-granules...
  12. Kam W Leong; Fiscal Year: 2015
    ..Upon treatment, 20-30% of patients with hemophilia A (factor VIII deficiency) and 1...
  13. In vivo lentiviral transduction of bone marrow cells for hemophilia gene therapy
    Carol H Miao; Fiscal Year: 2013
    ..gene therapy strategy to treat hemophilia A (HemA) by directly transferring lentiviral vectors encoding factor VIII (FVIII) gene into bone marrow cells...
  14. Induction of Tolerance to Factor VIII in Hemophilia
    DAVID WILLIAM SCOTT; Fiscal Year: 2012
    Hemophilia A is an X-linked disorder in which clotting factor VIII (fVIII) mutations lead to a loss of fVIII expression and serious bleeding...
  15. RAMP Mediated Gene Delivery
    Kevin G Rice; Fiscal Year: 2012
    ..RAMP polyplexes will be used to treat Factor VIII deficiency in hemophilic mice...
  16. Structure and Stability Studies of Factor VIII to Overcome the Immune Response
    PAUL CLINTON SPIEGEL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Blood coagulation factor VIII is a non-enzymatic glycoprotein cofactor that is essential for proper regulation of the blood coagulation cascade...
  17. Bioengineered factor VIII gene therapy for hemophilia A
    H Trent Spencer; Fiscal Year: 2012
    ..we have shown that the transplantation of genetically-engineered hematopoietic stem cells can restore factor VIII (fVIII) activity to curative levels in hemophilia A mice and that human hematopoietic stem cells are readily ..
  18. Blocking the immune response to Helper-dependent adenovirus vector for Hemophilia
    Masataka Suzuki; Fiscal Year: 2011
    ..Project Abstract. Hemophilia A (HA) is a common disorder of coagulation caused by deficiency of factor VIII (FVIII). The mainstay of treatment has been replacement therapy with recombinant human FVIII...
  19. STRUCTURE AND REGULATION OF HUMAN FACTOR VIII
    Philip J Fay; Fiscal Year: 2013
    ..A, the most common of the severe, inherited bleeding disorders, results from a deficiency or defect in factor VIII. We propose to define critical aspects of factor VIII structure and regulation that includes fine point details of ..
  20. Hemophilia Adult Prophylaxis Study
    MARGARET VICTORIA RAGNI; Fiscal Year: 2012
    ..the feasibility of conducting a Phase III randomized clinical trial comparing two doses of recombinant factor VIII (r.FVIII) prophylaxis in adults with severe hemophilia A...
  21. Shannon L Meeks; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Inhibitory antibodies to factor VIII (fVIII) develop in approximately 30% of patients with severe hemophilia A in response to infusions of fVIII...
  22. Masataka Suzuki; Fiscal Year: 2015
    ..Project Abstract. Hemophilia A (HA) is a common disorder of coagulation caused by deficiency of factor VIII (FVIII). The mainstay of treatment has been replacement therapy with recombinant human FVIII...
  23. In vivo function and tolerance to Factor VIII variants
    BRENDAN HL LEE; Fiscal Year: 2011
    Hemophilia A (HA) is a common disorder of coagulation caused by deficiency of factor VIII (FVIII). The mainstay of therapy has been replacement therapy with recombinant human FVIII...
  24. Feasibility of the Hemophilia INHIBIT Trial
    MARGARET VICTORIA RAGNI; Fiscal Year: 2013
    ..provided by applicant): Hemophilia A is an X-linked bleeding disorder resulting from deficiency of factor VIII, and characterized by bleeding into joints, muscles, and body cavities...
  25. FIV Vectors for the Treatment of Hemophilia A
    William C Raschke; Fiscal Year: 2012
    ..The lack of sufficient expression levels Factor VIII (FVIII) in hemophilic patients indicates that further improvements of the current gene delivery systems are needed ..
  26. Combined Factor VIII Replacement and Tolerance Therapy for Hemophilia A
    ANNE SEARLS DEGROOT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this new SBIR program is to produce a combined clotting Factor VIII replacement and immunomodulatory therapy that will provide FVIII-specific tolerance induction at therapeutic doses for ..
  27. Randal J Kaufman; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Factor VIII (FVIII) is the protein deficient or functionally defective in hemophilia A, an X chromosome-linked bleeding disorder affecting 1/5,000 males...
  28. Andrew M Davidoff; Fiscal Year: 2015
    ..virus (AAV) vectors can safely mediate long-term expression of therapeutic levels of coagulation factor VIII (FVIII) for the treatment of hemophilia A...
  29. Epitope-driven deimmunization of Factor VIII
    ANNE SEARLS DE GROOT; Fiscal Year: 2010
    Hemophilia A patients are prone to develop inhibitory immune responses to the very therapy they require: Factor VIII protein replacement...
  30. CHAR MARIE WITMER; Fiscal Year: 2014
    ..is the most common severe congenital bleeding disorder and is the result of a deficiency of the clotting factor (F) VIII. Clinical severity is largely determined by a patient's baseline factor level: severe (<1%), moderate (1-5%)..
  31. Bin Zhang; Fiscal Year: 2016
    Description (provided by the applicant): Coagulation factors V (FV) and factor VIII (FVIII) are both secreted glycoproteins that share pivotal roles in both hemostasis and thrombosis...
  32. SATHY VENKAT BALU-IYER; Fiscal Year: 2016
    ..provided by applicant): The development of antibody responses against therapeutic proteins such as Factor VIII (FVIII) is a major clinical complication that compromises the safety and efficacy of protein based therapeutics...
  33. Roland W Herzog; Fiscal Year: 2016
    ..we will extent investigations on the immunology of hepatic AAV gene transfer to treatment of hemophilia A (factor VIII, F.VIII, deficiency), the more common form of hemophilia. F...
  34. Evaluation of the Antigenicity of Black Restricted FVIII Haplotypes and Haplotype
    James W Lillard; Fiscal Year: 2013
    Evaluation of the Antigenicity of Black-Restricted Haplotypes of Factor VIII ABSTRACT About 30% of congenital Hemophilia A (HA) patients develop alloantibodies that neutralize the activity of replacement Factor (F) VIII proteins...
  35. CHRISTINE LUISE KEMPTON; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The development of neutralizing anti-factor VIII (fVIII) antibodies, inhibitors, is the most significant complication affecting treated patients with hemophilia A (HA)...
  36. Patient-Level Meta-analysis: Effect of age of initiation, intensity and duration
    Marilyn J Manco-Johnson; Fiscal Year: 2013
    ..Effects of age of initiation, duration of therapy and intensity of treatment (dosing schedule) with factor VIII prophylaxis on prevention of hemophilic arthropathy using joint scoring via sensitive and specific magnetic ..
  37. Molecular engineering of factor VIII gene for rAAV delivery
    Weidong Xiao; Fiscal Year: 2012
    ..This disease is primarily caused by deficiency in the factor VIII gene located in the X-chromosome and is difficult to treat by conventional medicine...
  38. Mechanism of HPA Axis Activation: Role of Nicotinic Acid Receptor in the Brain
    Jang H Youn; Fiscal Year: 2012
    ..these effects are blocked by an icv infusion of pertussis toxin (PTX;G-protein inhibitor) or cyclooxygenase (COX;or prostaglandin synthase) inhibitors...
  39. William L Smith; Fiscal Year: 2014
    ..Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2), also known as cyclooxygenases-1 and -2 (COX-1 and COX-2), catalyze the conversion of arachidonic acid (AA) to prostaglandin H2 (PGH2) in the committed step of ..
  40. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..will lead to a follow- up proposal to obtain funding to evaluate novel biomarkers of VTE risk such as factor VIII, von Willebrand factor levels, and genetic factors in African-Americans versus European-Americans...
  41. Social Networks &Breast Cancer Prognosis in the Chinese and US Evaluation Study
    Candyce H Kroenke; Fiscal Year: 2013
    ..Multiple linear and logistic regression will be used to evaluate associations with behavioral factors, and Cox models will be used to evaluate associations with mortality, after evaluating heterogeneity...
  42. Christianne L Roumie; Fiscal Year: 2016
    ..We will use the marginal structural Cox proportional hazards models (MSM) using "stabilized" Inverse probability treatment weights (IPTW)...
  43. Access to Liver Transplantation for Patients with Primary Sclerosing Cholangitis
    David Seth Goldberg; Fiscal Year: 2011
    ..Our first aim will address this primary research question in three ways. We will develop two Cox proportional hazard models, one accounting for all of a patient's MELD scores while on the waitlist, and ..
  44. Lisa Fredman; Fiscal Year: 2014
    ..We will use mixed longitudinal models and Cox proportional hazards models to test four hypotheses in all participants and in caregivers only...
  45. Ambulatory Case and Preventable Hospitalizations in Diabetic Kidney Disease
    Chin Lin Tseng; Fiscal Year: 2013
    ..We will evaluate their annual trends using logistic regressions with Generalized Estimating Equations (GEEs). Cox proportional hazards models will be used to evaluate the associations of consistency of subspecialty care and other ..
  46. Arsenic Exposure, Cardiovascular Disease and Diabetes in Native Americans
    Ana Navas-Acien; Fiscal Year: 2011
    ..Statistical analysis: Cox proportional hazard models will be used to assess the prospective association of urine arsenic species ..
  47. CVD Predictors of Cognitive Function Trajectory over 20 Years
    Elizabeth L Barrett Connor; Fiscal Year: 2010
    ..We will examine predictors of categorically-defined successful cognitive aging using Cox proportional hazard models...
  48. Cynthia J Brown; Fiscal Year: 2014
    ..Multilevel change or random-effects regression models will be used to examine life-space trajectories over time and Cox proportional hazards models to evaluate predictors of adverse outcomes...
  49. MEASUREMENT ERRORS IN ENVIRONMENTAL EPIDEMIOLOGY
    DONNA L SPIEGELMAN; Fiscal Year: 2013
    ..the regression calibration method for adjustment for measurement error in multivariate regression models, including Cox models and logistic models, to accommodate the study designs and data structures encountered in environmental ..
  50. Obesity, Aging, and Cancer Cost (OACC) Study
    Benjamin M Craig; Fiscal Year: 2010
    ..MCBS), The New Mexico Mammography Project, The New Mexico Tumor Registry, and SEER-Medicare, we will estimate Cox proportional hazard models on the time to episode of care and exponential conditional mean models on the cost of ..
  51. Pesticide Use & Breast Cancer Risk in Large Cohort of Female Agriculture Workers
    LAWRENCE STUART ENGEL; Fiscal Year: 2010
    ..Relative risks will be estimated using data from both interviews (pre-diagnostic only), via Cox proportional hazards models including the full cohort, as well as separately by menopausal status and state of ..
  52. The Quality of Buprenorphine Treatment for Medicaid Beneficiaries
    Jeffrey D Baxter; Fiscal Year: 2013
    ..Finally, for aim 3, using Cox proportional hazards models we will measure the association between receiving care according to treatment ..
  53. Amanda Hyre Anderson; Fiscal Year: 2015
    ..All proposed investigations will occur within the cohort framework of the CRIC Study utilizing Cox proportional hazards models, mixed effects growth curve models, and marginal structural models with time-updated ..
  54. Health of Children Born by Mothers with Pheumatoid Arthritis
    Jorn Olsen; Fiscal Year: 2012
    ..Statistical analyses: Data will be analyzed using Cox models...
  55. Mary Sano; Fiscal Year: 2015
    ..Cumulative transition rates will be estimated based on the survival curves generated from the Cox models...
  56. SPRY2 predicts survival post-chemotherapy in advanced ovarian cancer.
    Raymond P Perez; Fiscal Year: 2010
    ..In aim 1, SPRY2 and Cbl protein levels, assayed by quantitative automated immunohistochemistry, are entered into Cox models as potential predictors of survival and disease-free interval...
  57. Martha L Slattery; Fiscal Year: 2016
    ..groups of miRNAs using recent extensions of several statistical methods including ANOVA, logistic regression, and Cox proportional hazards models...
  58. Determining Processes of Cardiovascular Care Relevant to Complex Patients
    Elizabeth A Bayliss; Fiscal Year: 2010
    ..We will use linear regression models and Cox proportional hazard models to assess the impact of the cancer prognosis and other morbidity scores (and their ..
  59. Donna B Jeffe; Fiscal Year: 2015
    ..We will examine gender and race/ethnicity differences in time to faculty promotion and attrition using Cox proportional hazard models and Kaplan-Meier curves...
  60. Risk and Risk Preferences for Surgery and Medical Therapy in Ulcerative Colitis
    Meenakshi Bewtra; Fiscal Year: 2013
    ..b>Cox proportional hazards models with adjustment will be used to detemnine relative survival of UC patients treated with ..
  61. Rajender R Aparasu; Fiscal Year: 2015
    ..Propensity score adjusted multivariate analyses including Cox models will be used to evaluate the safety profile of anticholinergics...
  62. Comparative Risk of Endometrial Cancer from Ablation Versus Medical Management
    BRIAN LESLIE STROM; Fiscal Year: 2012
    ..It will examine the relative risk of endometrial cancer using Cox proportional hazard models~ it will investigate diagnostic delay by comparing median time from DUB diagnosis to ..
  63. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..g., Factor VIII) integrity;(2) test prototypical and emerging viruses and bacteria in human plasma in extant SFS-CFI units and in ..
  64. C Yan Cheng; Fiscal Year: 2016
    ..that maintains BTB integrity as preleptotene and leptotene spermatocytes traverse the BTB that occurs at stage VIII of the seminiferous epithelial cycle of spermatogenesis...
  65. Ian C Michelow; Fiscal Year: 2016
    ..effects logistic regression modeling to account for repeated measures and confounding variables as well as the Cox proportional hazards survival model to compare time to predefined endpoints...
  66. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..Amongst several other targets, factors such as transforming growth factor-ss1 (TGF-ss1), and COX-2 are upregulated in adult tissue and show reduced expression in fetal skin...
  67. COX Inhibition & Musculoskeletal Responses to Exercise
    Wendy M Kohrt; Fiscal Year: 2010
    ..As noted by the new title, COX Inhibition &Musculoskeletal Responses to Exercise, the application is a continuation of the study of factors ..
  68. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..development of collagen-induced arthritis in mice(CIA);and (2) bioavailable PFE constituents/metabolites inhibited COX-2 activity and IL-1[unreadable]-induced production of NO and PGE2 in chondrocytes...
  69. Use of Novel Cox-2 Inhibitors in Neurological Disorders
    STANLEY BELL; Fiscal Year: 2006
    ..Numerous studies indicate that the enzyme cyclooxygenase-2 (COX-2) is induced by oxidative stress, contributes to oxidative stress, and promotes subsequent neuronal injury...
  70. Xianglin Shi; Fiscal Year: 2015
    ..These inflammatory mediators include infiltrating leukocytes and myeloperoxidase (MPO), COX-2, PGE2, and several pro-inflammatory cytokines, TNF-1, IL-2, and IL-6. Specific Aim 4...
  71. MECHANICAL LOADING OF BONE AND PROSTAGLANDINS
    Carol C Pilbeam; Fiscal Year: 2010
    ..Loading stimulates new bone formation and unloading causes bone loss. Cyclooxygenase (COX)-2, the major enzyme for prostaglandin (PG) responses in bone, can enhance both bone formation and resorption and ..
  72. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2009
    ..There are two cyclooxygenases, COX-1 and COX-2. COX-1 is usually expressed constitutively;COX-2 is induced by many stimuli...
  73. Flavonoids, esophageal/gastric cardia adenocarcinoma and Barretts Esophagus Risk
    Marilie D Gammon; Fiscal Year: 2013
    ..A number of flavonoids are also COX-2 inhibitors and some can suppress COX-2 transcription...
  74. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..The cyclooxygenases COX-1 and COX-2 catalyze the first committed step in prostaglandin synthesis, and the inducible isoform COX-2 promotes ..
  75. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cyclooxygenases (COXs: COX-1/-2) and 5-lipoxygenase (5-LOX) catalyzed reactions play significant roles in colon cancer progression...
  76. PHILIPPE ANDRE GALLAY; Fiscal Year: 2014
    ..T cells ex vivo;vii) is extremely efficacious since less than 15 min of exposure suffices for C5A to neutralize HIV;viii) is potent for a considerable length of time both prior to (at least 1 h) and after (at least 1 h) addition of HIV ..
  77. John P Lynch; Fiscal Year: 2016
    ..b>Cox-1 and Cox-2 are the rate-limiting enzymes in prostaglandin biosynthesis...
  78. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2009
    ..S., is newly diagnosed in 150,000 persons each year. Chemoprevention through cyclooxygenase-2 (COX-2) specific NSAIDs is being proposed as a viable means of reducing the incidence of colorectal polyps, the ..
  79. Howard B Lieberman; Fiscal Year: 2016
    ..suppressor", upregulation of the gene and subsequent transactivation of at least three downstream targets, Cox-2, Flt-1 and p21. We also provide evidence of a new carcinogenesis related function for Rad9, in metastasis...
  80. Lawrence J Marnett; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Cyclooxygenase-2 (COX-2) plays a key role in the conversion of arachidonic acid (AA) to prostaglandins, which are an important class of bioactive lipids...
  81. Gadiparthi N Rao; Fiscal Year: 2015
    ..Arachidonic acid (AA), which is produced primarily by PLA2s, metabolizes via the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 monooxygenase (CYP) pathways producing prostaglandins (PGs), ..
  82. Chemopreventive effect of fish oil derived EPA in lung cancer
    Peiying Yang; Fiscal Year: 2013
    ..Finding effective preventive and treatment strategies for lung cancer are desperately needed. Cyclooygenase-2 (COX-2), a key mediator of inflammation, is an important target for lung cancer therapy and prevention because ..
  83. Claus Schneider; Fiscal Year: 2015
    ..via separate pathways following the initial oxygenation of arachidonic acid by either cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LOX), respectively...
  84. Francis Perry Wilson; Fiscal Year: 2016
    ..the predictive ability of various proxies of muscle mass and function with all-cause mortality primarily using Cox regression. We will assess the discriminant ability of these measures using C-statistics...
  85. Ellen Merrick Schill; Fiscal Year: 2015
    ..be analyzed by immunohistochemistry and time-lapse imaging to determine if ibuprofen inhibits ENCC migration via a Cox- dependent mechanism...
  86. Prakash R Rai; Fiscal Year: 2014
    ..of chemo-preventive agents which include selective estrogen receptor antagonists, aromatase inhibitors, retinoids, COX-2 inhibitors and metformin...
  87. IVAN B YANACHKOV; Fiscal Year: 2015
    ..The main antiplatelet drugs in clinical use today - aspirin and clopidogrel - target platelet COX-1 and P2Y12 platelet receptors, respectively...
  88. Harvey J Murff; Fiscal Year: 2014
    ..Secondary endpoints will include rectal epithelial cell expression of COX-2 and 15-PGDH, rectal cell production of PGE2 and PGE3, rectal mucosal tissue levels of fatty acids, and changes in ..
  89. Gary A Piazza; Fiscal Year: 2016
    ..drugs (NSAIDs) strongly inhibit tumorigenesis in experimental animal models, but toxicity from cyclooxygenase (COX) inhibition limits their use in humans for cancer chemoprevention...
  90. LAURA ELIZABETH FREDENBURGH; Fiscal Year: 2016
    ..pulmonary arteries develop a striking hyper-proliferative phenotype, decreased expression of cyclooxygenase (COX)-2, reduced prostaglandin I2 synthesis, and increased secretion of endothelin-1...
  91. Gary A Piazza; Fiscal Year: 2015
    ..Unfortunately, toxicity resulting from cyclooxygenase (COX) inhibition and incomplete protection from disease progression in all individuals, limits their use for ..
  92. ANDREW JESS DANNENBERG; Fiscal Year: 2015
    ..Importantly in this respect, a key role has been established for cyclooxygenase (COX)-derived prostaglandin E2 (PGE2) in stimulating transcription of the CYP19 gene which encodes the aromatase enzyme...
  93. William L Hughes; Fiscal Year: 2015
    ..to reinforce learning via teaching, vii) participating in conferences such as the Materials Research Society (MRS) and Foundations of Nanoscience (FNANO) to network, and viii) writing proposals alongside and independent of the mentor.
  94. EMILY YIN CHU; Fiscal Year: 2014
    ..Recent studies in the Cox laboratory have found that IRF6 binds, in a phosphorylation-enhanced manner, to NME2 (non-metastatic 2), which has ..
  95. TGF-beta1 and Mitochondrial Dysfunction in LPS-Induced Renal Failure
    L Jay Stallons; Fiscal Year: 2013
    ..Urine output was minimal at 42 h. Mitochondrial electron transport chain and ATP synthesis proteins [i.e. NDUFB8, COX I and ATP synthase [unreadable] (ATPS [unreadable])] were depleted at 42 h after LPS injection...
  96. PC-NSAIDs for Chemoprevention of Colorectal Cancer
    Lenard M Lichtenberger; Fiscal Year: 2013
    ..IBU-PC and INDO-PC inhibit the early stages of colon cancer progression including: inhibition of: cyclooxygenase (COX) activity, reducing the expression of COX-1, COX-2 and mdr-1;and their ability to disrupt Ras-signaling events...
  97. JAMES CHRISTOPHER BONNER; Fiscal Year: 2016
    ..pulmonary fibrosis and mesothelioma is due to reduced expression or impaired functional interaction between COX-2, STAT-1, and p53...