DAAM1

Summary

Gene Symbol: DAAM1
Description: dishevelled associated activator of morphogenesis 1
Alias: disheveled-associated activator of morphogenesis 1
Species: human

Top Publications

  1. ncbi Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1
    R Habas
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 107:843-54. 2001
  2. ncbi Crystal structure of human DAAM1 formin homology 2 domain
    Masami Yamashita
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama shi, Kanagawa 226 8501, Japan
    Genes Cells 12:1255-65. 2007
  3. pmc Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly
    Jun Lu
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Mol Biol 369:1258-69. 2007
  4. doi Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets
    Tomohito Higashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Biol Chem 283:8746-55. 2008
  5. pmc Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis
    Rong Ju
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 107:6906-11. 2010
  6. ncbi The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, Box 595, S 751 24 Uppsala, Sweden
    Exp Cell Res 312:2180-94. 2006
  7. pmc Mechanism of activation of the Formin protein Daam1
    Wei Liu
    Departments of Biochemistry, Robert Wood Johnson School of Medicine, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 105:210-5. 2008
  8. ncbi Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation
    Akira Sato
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson School of Medicine, Piscataway, NJ 08854, USA
    Development 133:4219-31. 2006
  9. pmc Critical roles for multiple formins during cardiac myofibril development and repair
    Michelle Rosado
    Biology Department and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454
    Mol Biol Cell 25:811-27. 2014
  10. pmc DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility
    Tamako Nishimura
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 215:559-573. 2016

Research Grants

  1. RACHEL KATHERINE MILLER; Fiscal Year: 2016
  2. Mechanisms enhancing functional coupling between native and embryonic stem cell d
    Karen Maass; Fiscal Year: 2013
  3. Sarah E Millar; Fiscal Year: 2016
  4. Jianbo Wang; Fiscal Year: 2015

Scientific Experts

  • M Katoh
  • Kristina Rydell-Törmänen
  • Dmitriy Mazurov
  • Pontus Aspenstrom
  • K Tanaka
  • Ye-Guang Chen
  • Claude Bouchard
  • Grace E Snow
  • Raymond Habas
  • Wei Liu
  • RACHEL KATHERINE MILLER
  • Karen Maass
  • Jianbo Wang
  • Sarah E Millar
  • Weiwei Luo
  • Tamako Nishimura
  • Tomohito Higashi
  • Bihui Bao
  • Bruce L Goode
  • Deepak K Khadka
  • Ed Manser
  • Yuriko Katoh
  • Hisanori Horiuchi
  • Ryutaro Shirakawa
  • Toru Kita
  • Tomoyuki Ikeda
  • Masa aki Nakaya
  • Aude Guillabert-Gourgues
  • Rieko Ajima
  • Dhananjay Wagh
  • Beatriz Lopez-Escobar
  • Akira Sato
  • Olga Ossipova
  • Gun Hwa Kim
  • Takayuki Yasunaga
  • Prakash Patil
  • Alexander D Bershadsky
  • Michael P Sheetz
  • Zi Zhao Lieu
  • Xiao Lin
  • M Asad
  • Michelle Rosado
  • Daphne Lehalle
  • Jeong Goo Lee
  • Ann Kathrin Hoffmann
  • Gai McMichael
  • Masatoshi Takeichi
  • Wiebke Cizelsky
  • Richa Jaiswal
  • Xiang Shun Cui
  • Jason D Gray
  • Juliane Bock
  • Witchuda Saengsawang
  • Zhiqing Liang
  • Hua Hu
  • Xiao Xu
  • Hyun Kyoung Lee
  • Wendy S Beane
  • Yichao Zhu
  • Sima Babayeva
  • Deqiang Li
  • Rachel K Miller
  • Beatriz Morte
  • Rong Ju
  • Chan Gao
  • Su Fen Ang
  • Takuji Tsuji
  • Anthony V Nguyen
  • Annalisa Astolfi
  • Hwee Goon Tay
  • Terry P Yamaguchi
  • Xi He
  • Kristi Lamonica
  • Mitsunori Kawato
  • Isabel P Laumanns
  • Katsuya Okawa
  • Steven N Salomon
  • Tamás Matusek
  • Shuya Fukai
  • Osamu Nureki
  • Jun Lu
  • Masami Yamashita
  • Ritu Bharti
  • Loren W Runnels
  • Yasuyuki S Kida
  • Sankar Maiti
  • Jin Kwan Han
  • James B Moseley
  • Eunjoo Park
  • Toshihiko Ogura

Detail Information

Publications80

  1. ncbi Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1
    R Habas
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 107:843-54. 2001
    ..Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled (Dvl) and a novel Formin homology protein Daam1. Daam1 binds to both Dvl and Rho, and mediates Wnt-induced Dvl-Rho complex formation...
  2. ncbi Crystal structure of human DAAM1 formin homology 2 domain
    Masami Yamashita
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama shi, Kanagawa 226 8501, Japan
    Genes Cells 12:1255-65. 2007
    ..Here, we present the crystal structure of human DAAM1 FH2 dimer at 2.8 A resolution. This is the first dimeric structure of the mammalian formin...
  3. pmc Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly
    Jun Lu
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Mol Biol 369:1258-69. 2007
    b>Daam1 (dishevelled-associated activator of morphogenesis-1) is a diaphanous-related formin first studied as a novel dishevelled binding protein and shown to be crucial for the planar cell polarity (PCP) pathway in Xenopus...
  4. doi Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets
    Tomohito Higashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Biol Chem 283:8746-55. 2008
    ..Here, we isolated two diaphanous-related formins, mDia1 and Daam1, in platelet extracts by GTP-RhoA affinity column chromatography...
  5. pmc Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis
    Rong Ju
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 107:6906-11. 2010
    ..expression of a constitutively active C-terminal domain of Dishevelled-associated activator of morphogenesis 1 (DAAM1) selectively inhibited endothelial cell proliferation...
  6. ncbi The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, Box 595, S 751 24 Uppsala, Sweden
    Exp Cell Res 312:2180-94. 2006
    ..One of the CIP4-binding proteins, DAAM1, was characterised in more detail...
  7. pmc Mechanism of activation of the Formin protein Daam1
    Wei Liu
    Departments of Biochemistry, Robert Wood Johnson School of Medicine, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 105:210-5. 2008
    ..Here we report that Daam1 is not significantly activated by Rho binding but rather by its interaction with Dishevelled (Dvl)...
  8. ncbi Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation
    Akira Sato
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson School of Medicine, Piscataway, NJ 08854, USA
    Development 133:4219-31. 2006
    ..We had previously identified the Formin homology protein Daam1 as an important link between Dishevelled and the Rho GTPase for cytoskeletal modulation...
  9. pmc Critical roles for multiple formins during cardiac myofibril development and repair
    Michelle Rosado
    Biology Department and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454
    Mol Biol Cell 25:811-27. 2014
    ..Using RNA interference silencing, we find that the formins mDia2, DAAM1, FMNL1, and FMNL2 are required nonredundantly for myofibrillogenesis...
  10. pmc DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility
    Tamako Nishimura
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 215:559-573. 2016
    ..We found that DAAM1, a formin family actin regulator, accumulated at the LCs, and its depletion caused dispersion of actin filaments ..
  11. pmc Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network
    Weiwei Luo
    Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore
    PLoS ONE 11:e0163915. 2016
    ..We previously described such a network that forms upon Latrunculin A (LatA) treatment, in which formin DAAM1 was localized at these nodes. Knock down of DAAM1 reduced the mobility of actin nodes but the nodes remained...
  12. pmc Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased β-catenin inhibition and increased Wnt5a/b interaction
    Kristina Rydell-Törmänen
    Lung Biology, Department Experimental Medical Science, Lund University, Lund, Sweden
    Physiol Rep 4:. 2016
    ..We investigated markers of Wnt signaling (β-catenin, Wnt3a, ICAT, Wnt5a/b, DAAM1 and NLK) histologically in lung parenchyma with variable degree of fibrosis...
  13. pmc Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway
    Aude Guillabert-Gourgues
    Adaptation Cardiovasculaire à l ischémie, INSERM, U1034, F 33600 Pessac, France
    Mol Biol Cell 27:941-53. 2016
    ..PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morphogenesis (Daam1), has been proposed to regulate cell actin cytoskeleton and microtubule (MT) reorganization for oriented cell ..
  14. pmc The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells
    Takayuki Yasunaga
    Renal Division, Department of Medicine, University of Freiburg Medical Center, 79106 Freiburg, Germany
    J Cell Biol 211:963-73. 2015
    ..interact with each other and that Inturned mediates the formation of ternary protein complexes between NPHP4 and DAAM1. Knockdown of daam1, but not formin-2, resulted in similar disruption of the subapical actin web, whereas nphp4 ..
  15. doi MiR-335-5p promotes chondrogenesis in mouse mesenchymal stem cells and is regulated through two positive feedback loops
    Xiao Lin
    School of Life Sciences, Tsinghua University, Beijing, China
    J Bone Miner Res 29:1575-85. 2014
    ..Molecular mechanism explorations revealed that miR-335-5p targets Daam1 and ROCK1, a set of negative regulators of Sox9; Sox9 downregulates the expression of miR-29a and 29b, both ..
  16. pmc DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly
    Rieko Ajima
    Mammalian Development Laboratory, National Institute of Genetics, Mishima 411 8540, Japan
    Dev Biol 408:126-39. 2015
    Wnt ligands regulate heart morphogenesis but the underlying mechanisms remain unclear. Two Formin-related proteins, DAAM1 and 2, were previously found to bind the Wnt effector Disheveled...
  17. doi scaRNAs regulate splicing and vertebrate heart development
    Prakash Patil
    Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan
    Biochim Biophys Acta 1852:1619-29. 2015
    ..g., GATA4, NOTCH2, DAAM1, DICER1, MBNL1 and MBNL2)...
  18. doi Multiple congenital anomalies-intellectual disability (MCA-ID) and neuroblastoma in a patient harboring a de novo 14q23.1q23.3 deletion
    Daphne Lehalle
    Département de Génétique Histologie Embryologie Cytogénétique, Hopital Necker Enfants Malades, Paris, France INSERM U781, Université Sorbonne Paris Cité, Institut Imagine, Paris, France
    Am J Med Genet A 164:1310-7. 2014
    ..In addition, we discuss the potential involvement in the clinical spectrum presented by the patient of five of the deleted genes, namely DAAM1, PLEKHG3, SPTB, AKAP5, and ARID4A.
  19. doi Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages
    Ann Kathrin Hoffmann
    Institute for Medical Microbiology, Virology, and Hygiene, University Medical Center Eppendorf, Hamburg, Germany
    FASEB J 28:3075-89. 2014
    ..In this study, we showed that the actin-regulatory formin Daam1 is important in Borrelia phagocytosis by primary human macrophages...
  20. doi The Wnt/JNK signaling target gene alcam is required for embryonic kidney development
    Wiebke Cizelsky
    Institute for Biochemistry and Molecular Biology, Ulm University, Albert Einstein Allee 11, Ulm 89081, Germany
    Development 141:2064-74. 2014
    ..Catenin-independent Wnt signaling through Fzd8, Inversin, Daam1, RhoA and Myosin is required for nephric tubule morphogenesis...
  21. pmc Interleukin-1β-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA
    Jeong Goo Lee
    USC Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Mol Cell Biol 34:3535-45. 2014
    ..in activation of disheveled protein (Dvl) and subsequently disheveled-associated activator of morphogenesis 1 (DAAM1). This leads to activation of Cdc42 and subsequent inhibition of RhoA...
  22. pmc FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway
    M Asad
    Cancer Science Institute of Singapore, Centre for Translational Medicine NUS Yong Loo Lin School of Medicine, Singapore, Singapore
    Cell Death Dis 5:e1346. 2014
    ..3 (CELSR3), prickle homolog 4 (Drosophila) (PRICKLE4), dishevelled-associated activator of morphogenesis 1 (DAAM1), profilin 2 (PFN2), protocadherin 9 (PCDH9), protocadherin α1 (PCDHA1), protocadherin β17 pseudogene (PCDHB17), ..
  23. pmc Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation
    Olga Ossipova
    Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Development 142:99-107. 2015
    ..Further experiments show that Vangl2, as well as Daam1 and Rho-associated kinase (Rock), regulate apical constriction of bottle cells at the blastopore and ectopic ..
  24. pmc The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye
    Beatriz Lopez-Escobar
    Grupo de Neurodesarrollo, Unidad de Gestión de Pediatría, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio, Centro Superior de Investigaciones Científicas, Universidad de Sevilla, 41013 Seville, Spain
    Dis Model Mech 8:157-68. 2015
    ..of elements in the non-canonical Wnt-PCP pathway, such as the Dishevelled-associated activator of morphogenesis 1 (Daam1) and Vangl2...
  25. pmc Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1
    Dhananjay Wagh
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California, United States of America
    PLoS ONE 10:e0120093. 2015
    ..Here we have identified Daam1, a Formin that functions with Profilin to drive F-actin assembly, as a novel Piccolo binding partner...
  26. ncbi Role of PKA as a negative regulator of PCP signaling pathway during Xenopus gastrulation movements
    Eunjoo Park
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk 790 784, South Korea
    Dev Biol 292:344-57. 2006
    ..As a negative component of PCP signaling, PKA inhibits not only the activation of RhoA and JNK but also the Dsh-Daam1-RhoA complex formation which is essential for the regulation of RhoA activity...
  27. pmc LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure
    Jason D Gray
    Brain and Mind Research Institute and Department of Neurology
    Hum Mol Genet 22:4267-81. 2013
    ..Lrp6 co-immunoprecipitated with Disheveled-associated activator of morphogenesis 1 (DAAM1), a formin promoting GEF activity in Wnt signaling...
  28. pmc Rare copy number variation in cerebral palsy
    Gai McMichael
    Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia
    Eur J Hum Genet 22:40-5. 2014
    ..3, and a 265-kb duplication of DAAM1. This is the first systematic study of CNVs in CP, and although it did not identify de novo mutations, has shown ..
  29. pmc Karyotypic and molecular genetic changes associated with fetal cardiovascular abnormalities: results of a retrospective 4-year ultrasonic diagnosis study
    Bihui Bao
    Department of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Int J Biol Sci 9:463-71. 2013
    ..To investigate the incidence of aneuploidy in fetuses with congenital heart defects (CHDs) and to further identify submicroscopic changes and global DNA methylation levels as potential biomarkers in complex CHD cases...
  30. pmc CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils
    Witchuda Saengsawang
    University of Wisconsin Madison, Department of Neuroscience, Madison, WI 53706, USA
    J Cell Sci 126:2411-23. 2013
    ..We also demonstrate that CIP4 dynamically colocalizes with Ena/VASP and DAAM1, two proteins known to induce unbranched actin filament arrays and play important roles in neuronal development...
  31. pmc ERG transcriptional networks in primary acute leukemia cells implicate a role for ERG in deregulated kinase signaling
    Juliane Bock
    Department of Hematology and Oncology, Charite, University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany
    PLoS ONE 8:e52872. 2013
    ..chromatin immunoprecipitation-on-chip of primary samples revealed 48 significantly enriched single genes including DAAM1 and NUMB...
  32. doi Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes
    Dmitriy Mazurov
    Laboratory of Immunochemistry, Institute of Immunology, Moscow, Russia
    FEBS J 280:1200-13. 2013
    ....
  33. doi Involvement of microRNA-335-5p in cytoskeleton dynamics in mouse oocytes
    Xiang Shun Cui
    Department of Animal Sciences, Chungbuk National University, Cheongju 361 763, Korea
    Reprod Fertil Dev 25:691-9. 2013
    ..be due to regulation of actin because perturbation of miR-335-5p resulted in reduced expression of actin nucleator Daam1, a member of the Formin family...
  34. pmc Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms
    Xiao Xu
    Departments of Medicine, Stony Brook University, Stony Brook, NY, USA
    Blood 120:3575-85. 2012
    ..datasets with functional reporter assays identified dishevelled associated activator of morphogenesis 1 (DAAM1) as a miR 490 5p protein target demonstrating decreased expression in ET platelets, putatively by translational ..
  35. pmc Deletion of a single-copy DAAM1 gene in congenital heart defect: a case report
    Bihui Bao
    Department of Gynecology and Obstetrics, South West Hospital, Third Military Medical University, Chongqing, China
    BMC Med Genet 13:63. 2012
    ..Here, we report a copy number deletion of chromosomal 14q23.1 in a female fetus with complex congenital heart defects. This is the first description of DAAM1 gene deletion associated with congenital heart anomalies.
  36. pmc Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development
    Wendy S Beane
    Biology Department and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Stem Cells Dev 21:2085-94. 2012
    ..Although traditionally studied as regulators of tissue polarity, we found that loss of the PCP genes Vangl2, DAAM1, and ROCK by RNA interference (individually or together) resulted in supernumerary eyes and excess optical neurons ..
  37. pmc The formin Daam1 and fascin directly collaborate to promote filopodia formation
    Richa Jaiswal
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Curr Biol 23:1373-9. 2013
    ..Here, we report that the mammalian formin Daam1 (Disheveled-associated activator of morphogenesis 1) is a potent actin-bundling protein and localizes all along ..
  38. pmc Analysis of the local organization and dynamics of cellular actin networks
    Weiwei Luo
    Mechanobiology Institute, National University of Singapore, Singapore 117411, Republic of Singapore
    J Cell Biol 202:1057-73. 2013
    ..with and linked by myosin II and containing the formin disheveled-associated activator of morphogenesis 1 (DAAM1) and the cross-linker filamin A (FlnA)...
  39. ncbi Formin proteins: purification and measurement of effects on actin assembly
    James B Moseley
    Rosenstiel Center, Brandeis University, Waltham, MA, USA
    Methods Enzymol 406:215-34. 2006
    ..formins Bni1 and Bnr1 but have extended them to mammalian formins, including mouse mDia1 and mDia2 and human Daam1. Thus, the approach we describe should be universally applicable to the purification and analysis of formins from ..
  40. pmc Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord
    Hyun Kyoung Lee
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 22:183-96. 2012
    The Daam family of proteins consists of Daam1 and Daam2. Although Daam1 participates in noncanonical Wnt signaling during gastrulation, Daam2 function remains completely uncharacterized...
  41. doi Planar cell polarity links axes of spatial dynamics in neural-tube closure
    Tamako Nishimura
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Cell 149:1084-97. 2012
    ..At these AJs, Celsr1 cooperates with Dishevelled, DAAM1, and the PDZ-RhoGEF to upregulate Rho kinase, causing their actomyosin-dependent contraction in a planar-polarized ..
  42. pmc Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration
    Yichao Zhu
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
    PLoS ONE 7:e37823. 2012
    The Dishevelled (Dvl) and Dishevelled-associated activator of morphogenesis 1 (Daam1) pathway triggered by Wnt5a regulates cellular polarity during development and tissue homoeostasis...
  43. pmc Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements
    Gun Hwa Kim
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea
    EMBO J 26:2513-26. 2007
    ..Furthermore, xbetaarr2 interacts with the N-terminal quarter of Daam1 and RhoA proteins, but not Rac1, and regulates RhoA activation through Daam1 activation for CE movements...
  44. ncbi Identification and characterization of rat Dact1 and Dact2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:1045-9. 2005
    DACT1 (DAPPER1), Frizzled receptors, MUSK receptor, VANGL1, VANGL2, PRICKLE1, PRICKLE2, DAAM1, Casein kinases, MARK3 (PAR1), PP2C, AXIN1, AXIN2, NKD1, NKD2, FRAT1, FRAT2 and CXXC4 are WNT signaling molecules associating with Dishevelled ..
  45. ncbi Identification and characterization of human DAAM2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:915-20. 2003
    ..Dishevelled proteins are implicated in the WNT - beta-catenin pathway and the WNT-PCP pathway. DAAM1/KIAA0666 is a Dishevelled-binding protein transducing WNT signals to the PCP pathway...
  46. ncbi Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1161-8. 2003
    FMNL (NM_005892.2) is a 5'-truncated partial cDNA encoding a Formin-homology protein related to DAAM1, DAAM2, DIAPH1 and DIAPH2. Here, we identified three members of FMNL gene family in the human genome by using bioinformatics...
  47. ncbi Identification and characterization of human FNBP3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:651-6. 2003
    FMNL1, FMNL2, FMNL3, DAAM1, DAAM2, DIAPH1 and DIAPH2 constitute the Formin-homology subfamily with FDD, FH1 and FH2 domains. FMNL2 gene is linked to FNBP3 (also known as HYPA) gene on human chromosome 2q23...
  48. ncbi Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:1015-9. 2003
    ..FMNL1/KW-13/FMNL, FMNL2/KIAA1902/FHOD2, FMNL3/KIAA2014, DAAM1, DAAM2, DIAPH1 and DIAPH2 are Formin-homology proteins with the FDD domain, while Fmn1, Fmn2, FHOD1 and Grid2ip/..
  49. ncbi Identification and characterization of human DIAPH3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:473-8. 2004
    ..3% total-amino-acid identity with DIAPH2. FMNL1/FMNL, FMNL2/FHOD2, FMNL3/WBP3, DAAM1, DAAM2, DIAPH1, DIAPH2 and DIAPH3 were classified as the FDD-type Formin homology proteins, while GRID2IP/..
  50. ncbi Identification and characterization of human FHOD3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:615-20. 2004
    ..FHOD1/FHOS, GRID2IP, Fmn1 and Fmn2 are non-FDD-type Formin homology proteins, while FMNL1, FMNL2/FHOD2, FMNL3, DAAM1, DAAM2, DIAPH1, DIAPH2 and DIAPH3 are FDD-type Formin homology proteins...
  51. ncbi Identification and characterization of human FHDC1, mouse Fhdc1 and zebrafish fhdc1 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:929-34. 2004
    ..FMNL1, FMNL2, FMNL3, DIAPH1, DIAPH2, DIAPH3, DAAM1 and DAAM2 are FDD-type Formin homology proteins, while FHOD1, FHOD3, GRID2IP, Fmn1 and Fmn2 are non-FDD-type ..
  52. ncbi Identification and characterization of the human FMN1 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:121-6. 2004
    ..GRID2IP and FHDC1 are non-FDD-type Formin homology proteins, while FMNL1, FMNL2, FMNL3, DIAPH1, DIAPH2, DIAPH3, DAAM1 and DAAM2 are FDD-type Formin homology proteins. Here, we identified the human FMN1 gene by using bioinformatics...
  53. ncbi Characterization of FMN2 gene at human chromosome 1q43
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:469-74. 2004
    ..GRID2IP and FHDC1 are non-FDD-type Formin homology proteins, while FMNL1, FMNL2, FMNL3, DIAPH1, DIAPH2, DIAPH3, DAAM1 and DAAM2 are FDD-type Formin homology proteins. Here, we characterized human FMN2 gene by using bioinformatics...
  54. ncbi Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Oncol Rep 12:939-43. 2004
    ..proteins, such as FMN1, FMN2, FHOD1, FHOD3, FHDC1, GRID2IP, FMNL1, FMNL2, FMNL3, DIAPH1, DIAPH2, DIAPH3, DAAM1 and DAAM2. Cdc50p is necessary for subcellular localization of Bni1p and asymmetrical cell division...
  55. ncbi Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system
    Yasuyuki Kida
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara, 630 0101, Japan
    Brain Res Dev Brain Res 153:143-50. 2004
    ..The observed expression patterns in developing central nervous tissues suggested that vertebrate Daam genes were involved in pivotal steps in neuronal cell differentiation and movement...
  56. ncbi Comparative integromics on FAT1, FAT2, FAT3 and FAT4
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 18:523-8. 2006
    WNT5A, WNT5B, WNT11, FZD3, FZD6, VANGL1, VANGL2, DVL1, DVL2, DVL3, PRICKLE1, PRICKLE2, ANKRD6, NKD1, NKD2, DAAM1, DAAM2, CELSR1, CELSR2, CELSR3, ROR1 and ROR2 are planar cell polarity (PCP) signaling molecules implicated in the ..
  57. ncbi Formin family proteins in cytoskeletal control
    K Tanaka
    Division of Biochemistry, Hokkaido University School of Medicine, Sapporo, 060 8638, Japan
    Biochem Biophys Res Commun 267:479-81. 2000
    ..Recent evidence indicates that the formin family proteins play a crucial role in the reorganization of the cytoskeleton. In this review, recent advance in the understanding of the functions of formin family proteins is discussed...
  58. ncbi Identification and comparative expression analyses of Daam genes in mouse and Xenopus
    Masa aki Nakaya
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH, 1050 Boyles St, Bldg 539, Rm 218, Frederick, MD 21702, USA
    Gene Expr Patterns 5:97-105. 2004
    ..Cross-species comparisons indicate that the expression domains of Xenopus Daam1 (XDaam1) mirror mDaam1 expression...
  59. ncbi WNT/PCP signaling pathway and human cancer (review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Oncol Rep 14:1583-8. 2005
    ..WNT/PCP signals are transduced to the RHOA signaling cascade through Formin homology proteins DAAM1 and DAAM2, and to the JNK signaling cascade through MAPKKKs and MAPKK4/7...
  60. pmc A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly
    Hwee Goon Tay
    Rho GTPases in Stem Cells Group, Institute of Medical Biology, Singapore, Singapore
    PLoS ONE 5:e10125. 2010
    ..This non-canonical Wnt pathway regulates RhoA-ROK/DAAM1 to control the acto-myosin network...
  61. doi Localization of the Diaphanous-related formin Daam1 to neuronal dendrites
    Steven N Salomon
    Center for Research in Neuroscience, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada
    Neurosci Lett 447:62-7. 2008
    ..In this study, we show that Daam1, a member of the Diaphanous-related formin protein family and a downstream effector for RhoA, is localized to the ..
  62. doi The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension
    Isabel P Laumanns
    Department of Internal Medicine, University Hospital of Giessen, Giessen, Germany
    Am J Respir Cell Mol Biol 40:683-91. 2009
    ..of further PCP mediators wingless member 11 (WNT11), disheveled associated activator of morphogenesis-1 (DAAM1), disheveled (DSV), and RHO-kinase (ROCK)...
  63. doi Formin proteins of the DAAM subfamily play a role during axon growth
    Tamás Matusek
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
    J Neurosci 28:13310-9. 2008
    ..We also show that mouse Daam1 rescues the CNS defects observed in dDAAM mutant flies to a high degree, and vice versa, that Drosophila DAAM ..
  64. pmc The planar cell polarity pathway directs parietal endoderm migration
    Kristi Lamonica
    Department of Biology, Wesleyan University, Hall Atwater Laboratories, Lawn Avenue, Middletown, CT 06459, USA
    Dev Biol 330:44-53. 2009
    ..Inhibition of the PCP pathway at the level of Daam1 also results in a loss of cell orientation along with an increase in cell migration, as seen with sFRP treatment...
  65. pmc Non-redundant roles for Profilin2 and Profilin1 during vertebrate gastrulation
    Deepak K Khadka
    Department of Biochemistry, Robert Wood Johnson School of Medicine, Piscataway, NJ 08854, USA
    Dev Biol 332:396-406. 2009
    ..We had previously identified the Formin protein Daam1 and an effector molecule XProfilin1 as links for Wnt-mediated cytoskeletal changes during gastrulation...
  66. pmc Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting
    Grace E Snow
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    BMC Cancer 9:383. 2009
    ..This study comprehensively investigated expression profiles of Wnt signalling components regulated during induced differentiation of EC cells and explored the role of key components in maintaining pluripotency...
  67. doi Dishevelled: The hub of Wnt signaling
    Chan Gao
    Tsinghua University, Beijing, China
    Cell Signal 22:717-27. 2010
    ..In the non-canonical Wnt pathways such as Wnt-Frizzled/PCP (planar cell polarity) signaling, Dvl signals via the Daam1-RhoA axis and the Rac1 axis...
  68. pmc Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase
    Tomohito Higashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 285:16231-8. 2010
    ..Diaphanous-related formins (DRFs), such as Daam1 and mDia1, play central roles in actin dynamics through assembling linear actin filaments...
  69. pmc Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord
    Yasuyuki S Kida
    Department of Developmental Neurobiology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1, Seiryo, Aoba, Sendai, Miyagi 980 8575, Japan
    Proc Natl Acad Sci U S A 104:6708-13. 2007
    ..We show that subcellular localization of Daam1, an essential component of noncanonical Wnt signaling, changes dynamically during notochord formation...
  70. pmc Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling
    Rachel K Miller
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Am Soc Nephrol 22:1654-64. 2011
    ..We found that during tubulogenesis, the developing pronephric anlagen expresses Daam1 and its interacting Rho-GEF (WGEF), which compose one PCP/noncanonical Wnt pathway branch...
  71. ncbi Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles
    Anthony V Nguyen
    Division of Hematology Oncology and Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA
    Int J Mol Med 26:121-5. 2010
    ..Genes involved in non-canonical Wnt signaling with increased expression in villous adenomas included rho-u, daam1, damm2, cxxc4 and nlk...
  72. doi Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes
    Sima Babayeva
    Department of Medicine, Nephrology Research Group, McGill University, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 300:F549-60. 2011
    ..The pathway is functional since Wnt5a causes redistribution of PCP proteins Dishevelled and Daam1. We also show that Wnt5a treatment changes podocyte morphology, alters nephrin distribution, increases the number ..
  73. doi A molecular portrait of gastrointestinal stromal tumors: an integrative analysis of gene expression profiling and high-resolution genomic copy number
    Annalisa Astolfi
    Interdepartmental Centre for Cancer Research G Prodi, University of Bologna, Bologna, Italy
    Lab Invest 90:1285-94. 2010
    ..1 region, which contains potentially novel tumor suppressors, including DAAM1, RTN1 and DACT1. siRNA-mediated RTN1 downregulation showed evidence for the potential role in GIST pathogenesis...
  74. pmc Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells
    Takuji Tsuji
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan
    Mol Biol Cell 21:3590-600. 2010
    ..Dishevelled (Dvl) and its binding protein Daam1 mediate RhoA activation in this pathway...
  75. pmc DAAM1 is a formin required for centrosome re-orientation during cell migration
    Su Fen Ang
    Rho GTPases in Stem Cells Group, Institute of Medical Biology Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 5:. 2010
    Disheveled-associated activator of morphogenesis 1 (DAAM1) is a formin acting downstream of Wnt signaling that is important for planar cell polarity...
  76. pmc Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis
    Deqiang Li
    Riley Heart Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 138:303-15. 2011
    Dishevelled-associated activator of morphogenesis 1 (Daam1), a member of the formin protein family, plays an important role in regulating the actin cytoskeleton via mediation of linear actin assembly...
  77. pmc Genomic predictors of the maximal O₂ uptake response to standardized exercise training programs
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Appl Physiol (1985) 110:1160-70. 2011
    ..Response to Exercise (DREW) study (n = 112): rs1956197 near dishevelled associated activator of morphogenesis 1 (DAAM1) and rs17117533 in the vicinity of necdin (NDN)...
  78. doi Monocyte-mediated regulation of genes by the amyloid and prion peptides in SH-SY5Y neuroblastoma cells
    Beatriz Morte
    Instituto de Investigaciones Biomédicas and Center for Biomedical Research on Rare Diseases CIBERER, Madrid, Spain
    Neurochem Int 58:613-9. 2011
    ..According to microarray analysis, not many coincidences are observed and only four genes (Hint3, Psph, Daam1 and c-Jun) appear to be commonly upregulated by both peptides...
  79. pmc MIM regulates vertebrate neural tube closure
    Wei Liu
    Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Development 138:2035-47. 2011
    ..previously identified as a Hedgehog response gene and actin and membrane remodeling protein, specifically binds to Daam1 and couples non-canonical Wnt signaling to neural tube closure...

Research Grants4

  1. RACHEL KATHERINE MILLER; Fiscal Year: 2016
    ..Our hypothesis is that the PCP components Daam1, WGEF, Prickle and Strabismus are required for primary cilia formation, which is in turn required for nephric ..
  2. Mechanisms enhancing functional coupling between native and embryonic stem cell d
    Karen Maass; Fiscal Year: 2013
    ..Based on preliminary data, I will investigate how the formin protein Daam1 enhances gap junction formation...
  3. Sarah E Millar; Fiscal Year: 2016
    ..pattern hair follicle development in embryonic skin;(2) Determine whether the non-canonical Wnt pathway components Daam1 and Daam2 act downstream of Wnt5a and control proliferation and hair follicle stem cell maintenance by regulating ..
  4. Jianbo Wang; Fiscal Year: 2015
    ..signaling is activated by non- canonical Wnt ligand Wnt5a in the SHF splanchnic mesoderm, (2) whether PCP effector Daam1, a novel Formin homology protein, functions downstream of Wnt5a and Wnt/PCP gene Disheveled (Dvl) in the SHF and (..