Genomes and Genes
Gene Symbol: DDX58
Description: DExD/H-box helicase 58
Alias: RIG-I, RIGI, RLR-1, SGMRT2, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, DEAD box protein 58, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, RNA helicase RIG-I, retinoic acid-inducible gene 1 protein, retinoic acid-inducible gene I protein
Publications217 found, 100 shown here
- Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responsesKiyohiro Takahasi
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060 0812, Japan
Mol Cell 29:428-40. 2008..Our results suggest that the bipartite structure of CTD regulates RIG-I on encountering viral RNA patterns...
- TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activityMichaela U Gack
Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA
Nature 446:916-920. 2007Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral ..
- Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-IYanli Wang
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Struct Mol Biol 17:781-7. 2010....
- Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactionsAmitava Mukherjee
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 284:6486-94. 2009....
- Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5Junji Xing
Institut fur Klinische und Molekulare Virologie, Universitatsklinikum, Friedrich Alexander Universitat, Erlangen, Germany
J Virol 86:3528-40. 2012..Taken together, the combined data indicate that HSV-1 US11 binds to RIG-I and MDA-5 and inhibits their downstream signaling pathway, preventing the production of IFN-β, which may contribute to the pathogenesis of HSV-1 infection...
- Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 proteinRicardo Rajsbaum
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
PLoS Pathog 8:e1003059. 2012..In conclusion, our results indicate that influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production...
- Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cellsRobert Besch
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
J Clin Invest 119:2399-411. 2009..Due to their immunostimulatory and proapoptotic activity, RIG-I and MDA-5 ligands have therapeutic potential due to their ability to overcome the characteristic resistance of melanoma cells to apoptosis...
- Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125Kei ichiro Arimoto
Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
Proc Natl Acad Sci U S A 104:7500-5. 2007..Because RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production...
- Seasonal and pandemic influenza H1N1 viruses induce differential expression of SOCS-1 and RIG-I genes and cytokine/chemokine production in macrophagesGustavo Ramírez-Martínez
Department of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
Cytokine 62:151-9. 2013..Infection with pandemic (pdm) A/H1N1 virus induces high levels of pro-inflammatory mediators in blood and lungs of experimental animals and humans...
- Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-IHiroyuki Oshiumi
Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
J Biochem 151:5-11. 2012..The splice variant of RIG-I encodes a protein that lacks the first CARD of RIG-I, and the variant RIG-I protein is not ubiquitinated by TRIM25. Therefore, ubiquitin is the key regulator of the cytoplasmic viral RNA sensor RIG-I...
- Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signallingKarin Pachler
Department of Molecular Biology, University of Salzburg, Billrothstrasse 11, 5020 Salzburg, Austria
Virol J 8:48. 2011....
- Active caspase-1-mediated secretion of retinoic acid inducible gene-IMin Jung Kim
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea
J Immunol 181:7324-31. 2008..Our data suggest a novel mechanism that negatively regulates RIG-I-mediated signaling activity via caspase-1-dependent secretion of RIG-I protein...
- Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanismsGuofeng Cheng
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:8499-504. 2006..The results also suggest that HCV blocks the synthetic dsRNA-induced signaling pathway at a point upstream of MAVS/IPS-1, and that it does so by an NS3-independent mechanism...
- DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potentialHiroyuki Oshiumi
Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
Eur J Immunol 40:940-8. 2010..Forced expression of DDX3 augmented virus-mediated IFN-beta induction and host cell protection against virus infection. Hence, DDX3 is an antiviral IPS-1 enhancer...
- Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene ILan Qin
State Key Laboratory of Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Peking Union Medical College and Chinese Academy of Medical Sciences, 9 Dong Dan San Tiao, Dongcheng District, Beijing 100730, PR China
Virol J 8:526. 2011..However, in addition to these targets, NSP1 may subvert innate immune responses via other mechanisms...
- Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytesKui Li
Department of Microbiology and Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1019, USA
J Biol Chem 280:16739-47. 2005..We conclude that hepatocytes contain two distinct antiviral signaling pathways leading to expression of type I IFNs, one dependent upon TLR3 and the other dependent on RIG-I, with little cross-talk between these pathways...
- Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusMasaki Mibayashi
Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
J Virol 81:514-24. 2007..Our results indicate that, in addition to sequestering dsRNA, the NS1 of influenza A virus binds to RIG-I and inhibits downstream activation of IRF-3, preventing the transcriptional induction of IFN-beta...
- Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expressionZao Zhong Su
Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Physiol 213:502-10. 2007..IRF-1 is a tumor suppressor and the expression profile of RIG-I together with its regulation by IRF-1 and the presence of a caspase-recruitment domain in RIG-I suggest that RIG-I might also possess tumor suppressor properties...
- Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetesTaeko Shigemoto
Laboratory of Molecular Genetics, Institute for Virus Research, and Laboratory of Molecular Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8507, Japan
J Biol Chem 284:13348-54. 2009..These results provide new insights into the structure-function relationship of RIG-I-like receptors as well as into human RIG-I-like receptor polymorphisms, antiviral innate immunity, and autoimmune diseases...
- Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virusMartin Schlee
Institute of Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, D 53127 Bonn, Germany
Immunity 31:25-34. 2009....
- Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune responseJulien Pothlichet
Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
PLoS ONE 4:e7582. 2009..Thus, its defectiveness may strongly impair the host antiviral immunity. Remarkably, very little information is available on RIG-I single-nucleotide polymorphisms (SNPs) presenting a functional impact on the host response...
- PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4Fuping You
The Education Ministry Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China
Nat Immunol 10:1300-8. 2009..The PCBP2-AIP4 axis defines a new signaling cascade for MAVS degradation and 'fine tuning' of antiviral innate immunity...
- The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradationPeyman Nakhaei
The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
PLoS Pathog 5:e1000650. 2009..Thus, Triad3A represents a versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection...
- Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon inductionLina Fan
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA
J Virol 84:1785-91. 2010....
- Unpaired 5' ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-IJean Baptiste Marq
Department of Microbiology and Molecular Medicine, University of Geneva School of Medicine, CMU, 9 Avenue de Champel, 1211 Geneva, Switzerland
J Biol Chem 285:18208-16. 2010..The presence of this unpaired 5' ppp-nucleotide is thus another way that some viruses appear to use to avoid detection by cytoplasmic pattern recognition receptors...
- Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunityWenwen Zeng
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Cell 141:315-30. 2010..Our results delineate the mechanism of RIG-I activation, identify CARD domains as a ubiquitin sensor, and demonstrate that unanchored K63-polyubiquitin chains are signaling molecules in antiviral innate immunity...
- A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cellsJianzhong Hu
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 185:424-32. 2010..to the induction of the IFNbeta gene, IFNB1, through the activation of the RNA helicase RIG-I, which is encoded by DDX58. Expression levels of IFNB1 and DDX58 in infected DCs showed positive correlations at the population and the ..
- RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-IMayra Solis
Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
J Virol 85:1224-36. 2011..This study reveals a novel PR-dependent mechanism employed by HIV-1 to counteract the early IFN response to viral RNA in infected cells...
- Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I)Marco Binder
Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany
J Biol Chem 286:27278-87. 2011....
- Hepatitis C virus reveals a novel early control in acute immune responseNoëlla Arnaud
Institut Pasteur, Hepacivirus and Innate Immunity, Paris, France
PLoS Pathog 7:e1002289. 2011..Among those, ISG15 acts to negatively control the RIG-I/MAVS pathway, at the level of RIG-I ubiquitination.These data give novel insights in the machinery involved in the early events of innate immune response...
- The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunityHelene Minyi Liu
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 7950, USA
Cell Host Microbe 11:528-37. 2012..Our results define 14-3-3ε as a key component of a RIG-I translocon required for innate antiviral immunity...
- Junín virus infection activates the type I interferon pathway in a RIG-I-dependent mannerCheng Huang
Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA
PLoS Negl Trop Dis 6:e1659. 2012....
- The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesMitsutoshi Yoneyama
Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
Nat Immunol 5:730-7. 2004..Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes...
- Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-IRhea Sumpter
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9048, USA
J Virol 79:2689-99. 2005..RIG-I is thus a pathogen receptor that regulates cellular permissiveness to HCV replication and, as an interferon-responsive gene, may play a key role in interferon-based therapies for the treatment of HCV infection...
- Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathwaysChen Zhao
Institute for Cellular and Molecular Biology, University of Texas, 2500 Speedway, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 102:10200-5. 2005..By targeting a wide array of constitutively expressed proteins, ISG15 conjugation greatly extends the repertoire of cellular functions that are affected by IFN-alpha/beta...
- Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunityMitsutoshi Yoneyama
Antiviral Innate Immunity Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Honkomagome, Tokyo, Japan
J Immunol 175:2851-8. 2005..These results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors...
- Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Rashu B Seth
Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell 122:669-82. 2005..The transmembrane domain targets MAVS to the mitochondria, implicating a new role of mitochondria in innate immunity...
- IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionTaro Kawai
Exploratory Research for Advanced Technology, Japan Science and Technology Agency
Nat Immunol 6:981-8. 2005..Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses...
- VISA is an adapter protein required for virus-triggered IFN-beta signalingLiang Guo Xu
Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
Mol Cell 19:727-40. 2005..These findings suggest that VISA is critically involved in both virus-triggered TLR3-independent and TLR3-mediated antiviral IFN signaling...
- Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusEtienne Meylan
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nature 437:1167-72. 2005..3 (TLR3) and the recently identified cytosolic RNA helicases RIG-I (retinoic acid inducible gene I, also known as Ddx58) and Mda5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard)...
- Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activationTsung Hsien Chang
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
Microbes Infect 8:157-71. 2006..Therefore, we suggest that JEV and DEN-2 initiate the host innate immune response through a molecular mechanism involving RIG-I/IRF-3 and PI3K/NF-kappaB signaling pathways...
- Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific mannerJesper Melchjorsen
Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
J Virol 79:12944-51. 2005..Therefore, there appears to be a large degree of cell-type specificity in the mechanisms used by the host to recognize infecting viruses...
- Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20Rongtuan Lin
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 281:2095-103. 2006..These results suggest that the virus-inducible, NF-kappaB-dependent activation of A20 functions as a negative regulator of RIG-I-mediated induction of the antiviral state...
- Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infectionYueh Ming Loo
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 103:6001-6. 2006..HCV protease inhibitors effectively prevent IPS-1 proteolysis, suggesting they may be capable of restoring this innate host response in clinical practice...
- Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokinesJukka Sirén
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
Microbes Infect 8:2013-20. 2006..In conclusion, our results show that in epithelial cells influenza A virus-induced antiviral cytokine gene expression is triggered by RIG-I and mda-5, whose expression is positively regulated by IFN-alpha...
- RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphatesAndreas Pichlmair
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
Science 314:997-1001. 2006....
- 5'-Triphosphate RNA is the ligand for RIG-IVeit Hornung
Division of Clinical Pharmacology, Department of Internal Medicine, University of Munich, 80336 Munich, Germany
Science 314:994-7. 2006....
- NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-IZhu Guo
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Respir Cell Mol Biol 36:263-9. 2007..These results provide further information on the mechanism by which IAV NS1 antagonizes the host antiviral response...
- GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVSZihong Chen
Department of Microbiology and Immunology, Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1019, USA
J Virol 81:964-76. 2007..These data provide further support for the use of GBV-B infection in small primates as an accurate surrogate model for deciphering virus-host interactions in hepacivirus pathogenesis...
- Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytesHideo Kitamura
Department of Dermatology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
J Dermatol Sci 45:127-34. 2007..Retinoic acid-inducible gene-I (RIG-I) is a member of the DExH/D box family proteins and designated as a putative RNA helicase, which plays various roles in gene expression and cellular functions in response to a variety of RNA viruses...
- Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2Takeshi Saito
Department of Microbiology, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75235 9048, USA
Proc Natl Acad Sci U S A 104:582-7. 2007..Modulation of RIG-I/LGP2 interaction dynamics may have therapeutic implications for immune regulation...
- Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cellsYoshihiro Hirata
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
J Immunol 179:5425-32. 2007..Virus replication and virus-induced cell death increased in IECs in which RIG-I was silenced, consistent with the importance of the RIG-I signaling pathway in IEC antiviral innate immune defense mechanisms...
- Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infectionRafael Atencia
Laboratorio de Inmunologia, Hospital de Cruces, Barakaldo, Vizcaya, Spain
BMC Infect Dis 7:136. 2007....
- The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-ISheng Cui
Gene Center, Department of Chemistry and Biochemistry, Ludwig Maximilians University of Munich, Feodor Lynen Strasse 25, 81377 Munich, Germany
Mol Cell 29:169-79. 2008..Structure-guided mutagenesis identifies a positively charged groove as likely 5'-triphosphate-binding site of RIG-I. This groove is distinct in MDA5 and LGP2, raising the possibility that RD confers ligand specificity...
- Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathwayJulien Pothlichet
Unité Défense Innée et Inflammation, INSERM U874, Institut Pasteur, 25 rue du Dr Roux, Paris, France
J Immunol 180:2034-8. 2008..Importantly, by using vectors overexpressing SOCS1 and SOCS3 we revealed that while both molecules inhibit antiviral responses, they differentially modulate inflammatory signaling pathways...
- Essential role of the N-terminal domain in the regulation of RIG-I ATPase activityPeter Gee
Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
J Biol Chem 283:9488-96. 2008....
- The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral responseConstantin S Friedman
Immunology Institute, Mount Sinai School of Medicine, Box 1630, One Gustave L Levy Place, New York, New York 10029, USA
EMBO Rep 9:930-6. 2008..These findings show that CYLD is a negative regulator of RIG-I-mediated innate antiviral response...
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingHiroki Ishikawa
Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
Nature 455:674-8. 2008..Thus, as well as identifying a regulator of innate immune signalling, our results imply a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA...
- Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transductionMichaela U Gack
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA
Proc Natl Acad Sci U S A 105:16743-8. 2008..This study not only elucidates the vital role of the intact tandem CARD for TRIM25-mediated RIG-I activation but also identifies the RIG-I SV as an off-switch regulator of its own signaling pathway...
- Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infectionHiroyuki Oshiumi
Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Biol Chem 284:807-17. 2009..We infer that a variety of RIG-I-ubiquitinating molecular complexes sustain RIG-I activation to modulate RNA virus replication in the cytoplasm...
- Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2Darja Bamming
Department of Biochemistry, Molecular Biology, and Cell Biology and Department of Medicine, Northwestern University, USA
J Biol Chem 284:9700-12. 2009..In addition, neither enzymatic activity nor RNA binding was required for negative regulation of antiviral signaling by LGP2, supporting an RNA-independent interference mechanism...
- Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-IMichaela Ulrike Gack
Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
Cell Host Microbe 5:439-49. 2009..Our findings reveal a mechanism by which influenza virus inhibits host IFN response and also emphasize the vital role of TRIM25 in modulating antiviral defenses...
- REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-IDong Gao
Key Laboratory of Cell Proliferation and Differentiation Ministry of Education, College of Life Sciences, Peking University, Beijing, China
PLoS ONE 4:e5760. 2009..These findings suggest that REUL is an E3 ubiquitin ligase of RIG-I and specifically stimulates RIG-I-mediated innate antiviral activity...
- 5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-IAndreas Schmidt
Division of Clinical Pharmacology, Department of Medicine, Ludwig Maximilian University Munich, 80336 Munich, Germany
Proc Natl Acad Sci U S A 106:12067-72. 2009..Together, our findings accurately define a minimal molecular pattern sufficient to activate RIG-I that can be found in viral genomes or transcripts...
- RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediateAndrea Ablasser
Institute for Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany
Nat Immunol 10:1065-72. 2009..This pathway was important in the sensing of Epstein-Barr virus-encoded small RNAs, which were transcribed by RNA polymerase III and then triggered RIG-I activation. Thus, RNA polymerase III and RIG-I are pivotal in sensing viral DNA...
- Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunityPaola M Barral
Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA
Pharmacol Ther 124:219-34. 2009..We also consider the function of these cytoplasmic sensors in apoptosis, development and differentiation, and diabetes...
- RIG-I is cleaved during picornavirus infectionPaola M Barral
Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, 1101 East Marshall Street, Sanger Hall Building, Room 11 015, Richmond, VA 23298 0033, USA
Virology 391:171-6. 2009..Rather, the viral proteinase 3C(pro) cleaves RIG-I, both in vitro and in cells. Cleavage of RIG-I during picornavirus infection may constitute another mechanism for attenuating the innate response to viral infection...
- RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathwayYu Hsin Chiu
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Cell 138:576-91. 2009..These results suggest that RNA Pol-III is a cytosolic DNA sensor involved in innate immune responses...
- Direct activation of protein kinases by unanchored polyubiquitin chainsZong Ping Xia
Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Nature 461:114-9. 2009..These results indicate that unanchored polyubiquitin chains directly activate TAK1 and IKK, suggesting a new mechanism of protein kinase regulation...
- Both RIG-I and MDA5 RNA helicases contribute to the induction of alpha/beta interferon in measles virus-infected human cellsSatoshi Ikegame
Department of Virology, Kyushu University, Fukuoka 812 8582, Japan
J Virol 84:372-9. 2010..Taken together, the present results indicate that RIG-I and MDA5 both contribute to the recognition of MV and that the V protein promotes MV growth at least partly by inhibiting the MDA5-mediated IFN responses...
- Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6Shu Li
College of Life Sciences, Modern Virology Center, Wuhan University, Wuhan 430072, China
J Biol Chem 285:4291-7. 2010..These findings suggest that OTUB1 and OTUB2 negatively regulate virus-triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and -6...
- Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccinationInna G Ovsyannikova
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
J Infect Dis 201:207-13. 2010..Genetic polymorphisms play an important role in rubella vaccine-induced immunity...
- Phosphorylation-mediated negative regulation of RIG-I antiviral activityMichaela U Gack
Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
J Virol 84:3220-9. 2010..While Thr-170 phosphorylation keeps RIG-I latent, Lys-172 ubiquitination enables RIG-I to form a stable complex with MAVS, thereby inducing IFN signal transduction...
- RIG-I detects viral genomic RNA during negative-strand RNA virus infectionJan Rehwinkel
Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A3PX, UK
Cell 140:397-408. 2010..Rather, single-stranded RNA viral genomes bearing 5'-triphosphates constitute the natural RIG-I agonists that trigger cell-intrinsic innate immune responses during infection...
- Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK betaFabrice Yoboua
Centre de recherche du CHUM Hôpital St Luc, 264 Rene Levesque Est, PEA 311, Montreal, Quebec H2X 1P1, Canada
J Virol 84:7267-77. 2010....
- The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responsesXiaobo Lei
State Key Laboratory of Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People s Republic of China
J Virol 84:8051-61. 2010..Together, these results suggest that inhibition of RIG-I-mediated type I IFN responses by the 3C protein may contribute to the pathogenesis of EV71 infection...
- The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling proteinCongwen Wei
Beijing Institute of Biotechnology, China
J Immunol 185:1158-68. 2010..By establishing a link between MAVS and HBX, this study suggests that HBV can target the RIG-I signaling by HBX-mediated MAVS downregulation, thereby attenuating the antiviral response of the innate immune system...
- Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencingAlina Baum
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 107:16303-8. 2010..Our analysis for the first time identifies RIG-I PAMPs under natural infection conditions and implies that full-length genomes of single segmented RNA virus families are not bound by RIG-I during infection...
- RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infectionA M A Nasirudeen
Institute of Molecular and Cell Biology, Singapore, Singapore
PLoS Negl Trop Dis 5:e926. 2011..Collectively, our studies demonstrate that the intracellular RNA virus sensors (RIG-I, MDA5 and TLR3) are activated upon DV infection and are essential for host defense against the virus...
- Immune signaling by RIG-I-like receptorsYueh Ming Loo
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 7650, USA
Immunity 34:680-92. 2011..Understanding the processes of RLR signaling and response will provide insights to guide RLR-targeted therapeutics for antiviral and immune-modifying applications...
- Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signalingStefanie A Morosky
Department of Microbiology and Molecular Genetics, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
J Biol Chem 286:28574-83. 2011....
- Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon productionEike R Hrincius
Institute of Molecular Virology, ZMBE, Von Esmarch Str 56, D 48149 Muenster, Germany
Cell Microbiol 13:1907-19. 2011..These data identify PI3K as factor that is activated as part of the Rig-I mediated anti-pathogen response to enhance expression of type I interferons...
- Structural basis of RNA recognition and activation by innate immune receptor RIG-IFuguo Jiang
Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA
Nature 479:423-7. 2011Retinoic-acid-inducible gene-I (RIG-I; also known as DDX58) is a cytoplasmic pathogen recognition receptor that recognizes pathogen-associated molecular pattern (PAMP) motifs to differentiate between viral and cellular RNAs...
- The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signallingFiliz Civril
Department of Biochemistry at the Gene Center, Ludwig Maximilians University Munich, Feodor Lynen Strasse 25, Munich 81377, Germany
EMBO Rep 12:1127-34. 2011..Overall, our results indicate that the activation of RIG-I occurs through an RNA- and ATP-driven structural switch in the SF2 domain...
- Structural insights into RNA recognition by RIG-IDahai Luo
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Cell 147:409-22. 2011....
- Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNAEva Kowalinski
European Molecular Biology Laboratory, Grenoble Outstation, France
Cell 147:423-35. 2011..These findings significantly advance our molecular understanding of the activation of innate immune signaling helicases...
- 55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformationMaiko Kageyama
Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan
Biochem Biophys Res Commun 415:75-81. 2011..These findings shed light on the structural regulation of RIG-I function...
- Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon inductionKay Childs
Division of Basic Medical Sciences, St George s, University of London, London, United Kingdom
J Virol 86:3411-21. 2012..This is significant, because it demonstrates a general mechanism for the targeting of the RIG-I pathway by paramyxoviruses...
- Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune responseXiaomo Jiang
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Immunity 36:959-73. 2012..These results suggest a unified mechanism of RIG-I and MDA5 activation and reveal a unique mechanism by which ubiquitin regulates cell signaling and immune response...
- Intracellular pathogen detection by RIG-I-like receptorsEvelyn Dixit
Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA, USA
Adv Immunol 117:99-125. 2013..RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction...
- RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cellsCristina Amparo Hagmann
Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany
PLoS ONE 8:e62872. 2013..Our results show that detection of Listeria RNA by RIG-I represents a non-redundant cytosolic immunorecognition pathway in non-immune cells lacking a functional STING dependent signaling pathway...
- USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptorsJun Cui
1 Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat Sen University, Guangzhou 510275, China 2 Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Houston, TX 77030, USA
Cell Res 24:400-16. 2014..Our findings identify a previously unrecognized role of USP3 in RIG-I activation and provide insights into the mechanisms by which USP3 inhibits RIG-I signaling and antiviral immunity. ..
- Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young childrenNico Marr
Department of Pediatrics, University of British Columbia and Children s and Women s Health Centre of British Columbia, Vancouver, British Columbia V6H 3V4, Canada
J Immunol 192:948-57. 2014..Our results suggest that human pDCs are less functional in early life, which may contribute to the increased susceptibility of infants and young children to severe RSV disease. ..
- Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytesAndrea Ablasser
Institute of Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, Bonn, Germany
J Immunol 182:6824-33. 2009....
- Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresiaKenichi Harada
Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
Hepatology 46:1146-54. 2007....
- Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritisKatharina Flür
Medical Policlinic, University of Munich, Germany
Am J Pathol 175:2014-22. 2009..Thus, TLR-independent recognition of viral RNA is a potent inducer of type I interferon in mesangial cells, which can be an important mediator of virally induced glomerulonephritis...
- Origin and evolution of the RIG-I like RNA helicase gene familyJun Zou
Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen, UK
BMC Evol Biol 9:85. 2009....
- Regulation of interferon production by RIG-I and LGP2: a lesson in self-controlDamien Vitour
Hepacivirus Unit, Pasteur Institute, Paris Cedex 15, France
Sci STKE 2007:pe20. 2007..The ability of RIG-I and LGP2 to exert such a feedback control at the earliest steps of IFN synthesis allows the cells to exert a tight regulation of the induction of the innate immune response...
- Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunityYueh Ming Loo
Department of Immunology, University of Washington School of Medicine, Box 357650, Seattle, WA 98195 7650, USA
J Virol 82:335-45. 2008....
- Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responsesThiagarajan Venkataraman
Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
J Immunol 178:6444-55. 2007..Collectively, our data indicate a disparate regulatory role for LGP2 in the triggering of innate immune signaling pathways following RNA virus infection...
- Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophilaKathryn M Monroe
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
PLoS Pathog 5:e1000665. 2009..Thus, our results provide new insights into the molecular mechanisms by which an intracellular bacterial pathogen activates and also represses innate immune responses...
- Helicase Regulation of dsRNA Signaling and Innate Antiviral Immune ResponsesCurt M Horvath; Fiscal Year: 2012..This strategy will reveal the strengths and vulnerabilities of the antiviral response and identify targets for therapeutic intervention. ..
- Innate Immunity and Herpes Simplex InfectionROBERT WILLIAM FINBERG; Fiscal Year: 2010..All Projects involve the use of common reagents and the definition of new paradigms related to recognition and response of the host to HSV. ..
- Evaluation of Novel DExD/H Helicases in Innate Immune SignalingGlen N Barber; Fiscal Year: 2013..2.) Characterization of FAH-1 and molecular mechanisms of action: We aim to evaluate the significance of FAH-1 in FADD-mediated innate immune regulation and determine this molecules importance in immune mechanisms of viral control. ..
- Innate Immune Sensing of Rift Valley Fever VirusAmy G Hise; Fiscal Year: 2010....
- Antonella Casola; Fiscal Year: 2014..Furthermore, the results obtained from these studies will be instrumental for the development of safer and more effective hMPV vaccines. ..
- Genetic Epidemiology of Life-Threatening Influenza Infection in ChildrenAdrienne Randolph; Fiscal Year: 2009..abstract_text> ..
- Genhong Cheng; Fiscal Year: 2015..We will also develop novel therapeutic agents to treat disease models associated with DNA virus infections such as genital herpes. ..
- Role of PISA;a PYHIN Family Member in Intracellular DNA RecognitionEicke Latz; Fiscal Year: 2013..Elucidation of molecular details of PISA activation could lead to novel strategies of pharmacological interference for diseases based on intracellular DNA recognition. ..
- Cellular responses to human metapneumovirus infectionXiaoyong Bao; Fiscal Year: 2011..The results obtained from these studies will be instrumental for the development of future hMPV vaccine candidates which are safe and effective. ..
- Jonathan C Kagan; Fiscal Year: 2016..By focusing on the earliest triggers of immune activation (the detection of viruses that enter our cells) we hope to uncover antiviral defense strategies that might be applicable to fight all infections. ..
- Pingwei Li; Fiscal Year: 2014..These studies will lead to the fundamental understanding about the molecular mechanism of antiviral immunity and will also provide critical information for potential therapeutic interventions. ..
- Immune Evasion Mechanisms of Neurovirulent AlphavirusesMark T Heise; Fiscal Year: 2012....
- A role for autophagy in increased cytosolic viral signaling in agingMichal Caspi Tal; Fiscal Year: 2011..I will then examine how this impacts the pathologies seen in aging, specifically the way in which a cell recognizes and responds to viral infection with age. ..
- Cellular Determinants of Apoptosis in Virus-Infected CellsGanes C Sen; Fiscal Year: 2013..Finally, genetically modified mice, including new IRF-3 mutant knock-in mice which have been generated for this project, will be used to assess the in vivo contribution of RIPA in controlling viral pathogenesis. ..
- Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cellsPaul R Knight; Fiscal Year: 2010..This treatment stimulates immunity against influenza virus, as well as interferes with the virus'ability to do damage to the airways. ..
- Role of small RNAs in innate immunity and inflammationMALATHI KRISHNAMURTHY; Fiscal Year: 2010....
- Peter Sarnow; Fiscal Year: 2016..To do this, novel biochemical, structural and genetic approaches will be employed to study protein-HCV RNA interactions. ..
- The functional role of DRH-1 in RNAi directed viral immunityRui Lu; Fiscal Year: 2013..Novel findings from the proposed studies may also shed light on some nematode-specific features of RDVI since DRH-1 is not conserved in fungi, plants or insects. ..
- Synergistic innate immune activation and cell killing by RIG-I ligands in HCV-HCCLee Gehrke; Fiscal Year: 2013..This proposal has the potential to foster new ideas about how both HCV infection and the liver cancer that often follows can be treated or prevented. ..
- Novel Vaccination Strategies Against Epidemic and Pandemic Influenza Viruses to IMurali Krishna Kaja; Fiscal Year: 2012..This knowledge will not only contribute to improved vaccination strategies against influenza, especially in elderly, but also has implications for novel vaccination strategies against a variety of diseases. ..
- Zhijian J Chen; Fiscal Year: 2015..If successful, our research should significantly advance the fields of immunology and virology, and provide new approaches to harness the host innate immunity to combat viral and autoimmune diseases. ..
- Role of TRIM proteins in the innate cellular antiviral response to HCVPENIEL MULUGETA DIMBERU; Fiscal Year: 2010..We will also investigate any effect of TRIMs on signaling downstream of IFN receptors, on the pathways that lead to upregulation of interferon-stimulated genes. ..
- Peter Sarnow; Fiscal Year: 2015..5 fold drop in viral load without any emergence of resistant virus (Lanford et al. 2010. Science: 327:198-201). ..
- Agonists of the RIG-I Innate Immune PathwaySHAWN PATRICK IADONATO; Fiscal Year: 2013..The significance of the program derives from the global burden of viral diseases that may be addressed by these new drug candidates. ..
- Novel viral element in pathogen recognition receptor signaling by hepatitis C virJinah Choi; Fiscal Year: 2010..The long-term goal is to determine the mechanism by which HCV evades host immune response to improve the efficacy of the existing therapy or to develop new anti-HCV agents. ..
- Defining the host antiviral response to West Nile VirusMEHUL SHAMAL SUTHAR; Fiscal Year: 2010..With no vaccine available and therapy to infection being only minimal, studies have to be conducted to better define the interface between the host antiviral response and WNV pathogenesis. ..
- AMPLIFICATION OF ANTIVIRAL INNATE IMMUNITY BY SUPPRESSOR OF VIRUS RNA (svRNA)Robert H Silverman; Fiscal Year: 2010..The knowledge to be gained from the proposed studies could contribute to improved treatments for viral infections. ..
- Glen N Barber; Fiscal Year: 2016....
- Impact of the interferon regulated proteins XAF1 and ZNF313 on innate immunityDouglas W Leaman; Fiscal Year: 2010....
- MICHELLE ALICE KELLIHER; Fiscal Year: 2016..abstract_text> ..
- Michael J Gale; Fiscal Year: 2016....
- Alan A Aderem; Fiscal Year: 2016..Systems approaches will then be used to integrate Foxo3 and the miRNAs into a global IRF7 regulatory network. Finally, we will examine the in vivo relevance of the IRF7- FOXO3-miRNA regulatory circuit in a mouse model of VSV infection. ..
- Virulence factors of influenza virus: The NS1 proteinAdolfo Garcia Sastre; Fiscal Year: 2010..abstract_text> ..
- Regulation of Type I Interferon Gene Expression in the Innate Immune ResponseKatherine A Fitzgerald; Fiscal Year: 2010..abstract_text> ..
- Robert H Silverman; Fiscal Year: 2015..In addition, these studies could lead to strategies for the treatment or prevention of cancers caused by oncogenic viruses. Therefore, there are cogent and health-related justifications for these studies. ..
- Agonists of the RIG-I Innate Immune PathwaySHAWN IADONATO; Fiscal Year: 2009..Because these drugs will activate the natural immune response, they are likely to be safer, more effective, and less prone to failure due to the ability of viruses to develop drug resistance. ..
- Cell-based assay for high-throughput screening of TLR3 activatorsTsung Hsien Chuang; Fiscal Year: 2010....
- FRANCIS VINCENT CHISARI; Fiscal Year: 2014..Collectively, these experiments will provide insight into viral evasion and host defense mechanisms that could lead to the development of novel antiviral strategies to terminate chronic HCV infection. ..
- Host-pathogen competition in IFN mediated antiviral defenseJae U Jung; Fiscal Year: 2013....
- Shyam S Mohapatra; Fiscal Year: 2015..The results are expected to lead to the discovery of novel targets and to the initiation of preclinical studies of these targets against RSV lung disease. ..
- Radhakrishnan P Iyer; Fiscal Year: 2015..The goal of this project is the advancement of SB 44 as a novel first-in-class orally bioavailable antiviral agent towards human clinical trials. ..
- YPE PETER DE JONG; Fiscal Year: 2015..Results obtained by these experiments can help prioritize which immunomodulatory therapies should best be pursued into clinical development. ..
- Michael J Gale; Fiscal Year: 2014..Our studies are linked with the U19 Clinical Core, and Projects 2 and 3 to feature translational approaches aimed at defining the virus-host interface that controls hepatic innate immunity and HCV infection. ..
- Michaela Ulrike Gack; Fiscal Year: 2016..Furthermore, this study will give detailed insights into viral immune evasion strategies, which may ultimately contribute to the establishment of novel therapeutic approaches for emerging virus-associated disorders. ..
- Siddharth Balachandran; Fiscal Year: 2014....
- RIG-I and TRIM25 mediated immune surveillance against virusJae U Jung; Fiscal Year: 2010..The proposed study is targeted to delineate the molecular mechanism underlying the host-viral interaction, with a specific focus on the RIG-I- and TRIM25-mediated IFN response. ..
- Structure and Function of the Hepatitis C Virus GenomePETER contact SARNOW; Fiscal Year: 2010..To do this, novel biochemical, structural and genetic approaches will be employed to study protein-HCV RNA interactions. ..
- Hepatitis C Virus Genetic Diversity and Modulation of Innate ImmunityGretja Schnell; Fiscal Year: 2012..Vaccine strategies are not currently available for preventing HCV infection, so understanding the virus-host interactions regulating innate immunity against HCV is necessary in order to develop new therapies and restrict infection. ..
- Activators and repressors of NFkappaB and IRF3/7 in innate immunityGEORGE ROBERT STARK; Fiscal Year: 2012..Our findings have the potential to lead to new therapeutic approaches in several disease settings. ..
- Modulation of Innate Immune Responses by CytomegalovirusKlaus J Früh; Fiscal Year: 2012..Ultimately, these in vitro results will allow us to test the importance of modulating the innate immune response in an emerging animal model for HCMV. ..
- The host response to Hepatitis C VirusMichael J Gale; Fiscal Year: 2012..The proposed studies will define the virus and host cell processes that trigger and control innate immunity and HCV infection outcome. ..
- Michael J Gale; Fiscal Year: 2016....
- MAVS protein: A role of mitochondria in innate immunity and cardioprotectionKirk Peterson; Fiscal Year: 2013..abstract_text> ..
- Innate Immunity: Mechanisms Linking with Adaptive ImmunityAndrew D Robertson; Fiscal Year: 2010....
- Akiko Iwasaki; Fiscal Year: 2014..the generation of innate and adaptive immunity against virus infections, these studies will help to establish important foundation with which to design vaccines and anti-infective measures against a variety of viral pathogens ..
- Initial study of the dendritic cell response to SeV DI particlesCAROLINA B LOPEZ; Fiscal Year: 2010..These studies are crucial for the comprehensive characterization of the DC mechanisms that efficiently respond to virus infection and should provide novel insights for the development of immunostimulatory molecules. ..
- Defining the role of the Inflammasome in immunity against Flavivirus InfectionHILARIO RAMOS; Fiscal Year: 2013....
- Defining double-stranded RNA receptor induced apoptosis in ovarian cancer.DANIELLE NICOLE SCHRAMM; Fiscal Year: 2010..This project seeks to define biomarkers that would identify dsRNA-responsive ovarian cancer tumors. ..
- Molecular mechanism of innate immunity control of HBV replicationHaitao Guo; Fiscal Year: 2011..Understanding of the robust and intricate innate antiviral pathway could potentially lead to the development of novel therapeutics to control HBV infections. ..
- Natural Phenotypic Diversity of HCV NS3/4A ProteaseDAVID RICHARD GRETCH; Fiscal Year: 2012..This proposal is significant because it describes and tests the potential pathogenic significance of naturally occurring mutations in HCV genomes during mild and severe disease progression. ..
- Robert E Lanford; Fiscal Year: 2014..In addition, persistent GBV-B infections would represent a new primate model for HCV disease progression. Furthermore, development of a primate model of targeted gene knockdown would be of great value in a number of research areas. ..
- Michael Levitt; Fiscal Year: 2016..This set of structures then provides a statistical sanity check, showing how much better the best model is than the next best one. ..
- BENJAMIN GOLDMAN-ISRAELOW; Fiscal Year: 2014....
- Negative Regulation of NLRP1-inflammasomes by the linear ubiquitin assembly complMary Rodgers; Fiscal Year: 2013....
- Blossom A Damania; Fiscal Year: 2016....
- Mechanisms of VSV-mediated OncolysisGlen N Barber; Fiscal Year: 2010..Understanding how these pathways function has significant impact on understanding pathogenesis and for developing novel therapeutics and vaccines to combat disease. ..
- Enterovirus PathogenesisVINCENT RACANIELLO; Fiscal Year: 2007..The biological role of poliovirus-induced cleavage of RIG-I and MDA-5 will be determined. Because poliovirus is a model pathogen, the results will contribute to the control of other medically relevant viruses. ..