DLX5

Summary

Gene Symbol: DLX5
Description: distal-less homeobox 5
Alias: SHFM1D, homeobox protein DLX-5, distal-less homeo box 5, split hand/foot malformation type 1 with sensorineural hearing loss
Species: human

Top Publications

  1. ncbi Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function
    Y Masuda
    Department of Geriatric Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka cho, Obu, Aichi 474 8522, Japan
    J Biol Chem 276:5331-8. 2001
  2. ncbi Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro
    C Morsczeck
    Stiftung Caesar, Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn 53175, Germany
    Calcif Tissue Int 78:98-102. 2006
  3. ncbi DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
    D D Eisenstat
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
    J Comp Neurol 414:217-37. 1999
  4. ncbi A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1
    Aya Sasaki
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi 474 8522, Japan
    J Biol Chem 277:22541-6. 2002
  5. pmc Cloning and characterization of two members of the vertebrate Dlx gene family
    A Simeone
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    Proc Natl Acad Sci U S A 91:2250-4. 1994
  6. doi A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice
    Yinfei Tan
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Res 68:1296-302. 2008
  7. doi Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients
    Tatsuya Kato
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 14:2363-70. 2008
  8. pmc Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus
    Evelyn N Kouwenhoven
    Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Genet 6:e1001065. 2010
  9. doi Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation
    Hanan E Shamseldin
    Developmental Genetics Unit, King Faisal Specialist Hospital and Research Center, Riyad 11211, Saudi Arabia
    J Med Genet 49:16-20. 2012
  10. ncbi Split hand/split foot malformation with hearing loss: first report of families linked to the SHFM1 locus in 7q21
    D Tackels-Horne
    JC Self Research Institute, Greenwood Genetic Center, SC 29646, USA
    Clin Genet 59:28-36. 2001

Research Grants

  1. The Role of Osteoactivin in Osteoblast Development and Function
    Fayez F Safadi; Fiscal Year: 2013
  2. Cun Yu Wang; Fiscal Year: 2016
  3. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    Joseph R Testa; Fiscal Year: 2013
  4. Molecular and Genetic Regulation of Craniofacial Development
    Brian L Black; Fiscal Year: 2013
  5. Richard A Schneider; Fiscal Year: 2016
  6. Lisa J Bain; Fiscal Year: 2014
  7. John L R Rubenstein; Fiscal Year: 2016
  8. JHUMKU DUTT KOHTZ; Fiscal Year: 2016
  9. The role of Foxi3 in inner ear development
    SAFIA BANO KHATRI; Fiscal Year: 2012
  10. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009

Detail Information

Publications242 found, 100 shown here

  1. ncbi Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function
    Y Masuda
    Department of Geriatric Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka cho, Obu, Aichi 474 8522, Japan
    J Biol Chem 276:5331-8. 2001
    b>Dlx5, a member of the Dlx family of homeodomain proteins, plays a critical role in bone development and fracture healing...
  2. ncbi Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro
    C Morsczeck
    Stiftung Caesar, Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn 53175, Germany
    Calcif Tissue Int 78:98-102. 2006
    ..These real-time PCR results display molecular mechanisms in dental follicle precursor cells during osteogenic differentiation that are different from those in bone marrow-derived mesenchymal stem cells...
  3. ncbi DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
    D D Eisenstat
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
    J Comp Neurol 414:217-37. 1999
    ..In the basal telencephalon, these DLX-positive cells differentiate into projection neurons of the striatum and pallidum as well as interneurons, some of which migrate to the cerebral cortex and the olfactory bulb...
  4. ncbi A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1
    Aya Sasaki
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi 474 8522, Japan
    J Biol Chem 277:22541-6. 2002
    Msx2 and Dlx5 are homeodomain proteins that play an important role in osteoblast differentiation and whose expression is induced by bone morphogenetic proteins...
  5. pmc Cloning and characterization of two members of the vertebrate Dlx gene family
    A Simeone
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    Proc Natl Acad Sci U S A 91:2250-4. 1994
    ..We cloned and studied the expression of two members of this family, which we named Dlx5 and Dlx6, in human and mouse...
  6. doi A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice
    Yinfei Tan
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Res 68:1296-302. 2008
    ..The proximal breakpoint maps to a region near a locus comprising the linked homeobox/transcription factor genes Dlx5 and Dlx6...
  7. doi Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients
    Tatsuya Kato
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 14:2363-70. 2008
    ..b>DLX5 gene, a member of the human distal-less homeobox transcriptional factor family that is expressed during early ..
  8. pmc Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus
    Evelyn N Kouwenhoven
    Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Genet 6:e1001065. 2010
    ..enhancer element in the SHFM1 locus on chromosome 7q and that this element controls expression of DLX6 and possibly DLX5, both of which are important for limb development...
  9. doi Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation
    Hanan E Shamseldin
    Developmental Genetics Unit, King Faisal Specialist Hospital and Research Center, Riyad 11211, Saudi Arabia
    J Med Genet 49:16-20. 2012
    ..7q21.3 (SHFM1) is one of six loci described to date, and although DLX5 and DLX6 are compelling candidates in that locus, no intragenic mutations have been described in either of these ..
  10. ncbi Split hand/split foot malformation with hearing loss: first report of families linked to the SHFM1 locus in 7q21
    D Tackels-Horne
    JC Self Research Institute, Greenwood Genetic Center, SC 29646, USA
    Clin Genet 59:28-36. 2001
    ..37 at theta = 0.0 for locus D7S527) at 80% penetrance. Efforts to identify the responsible gene have not yet been successful...
  11. ncbi Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1
    Zunyi Zhang
    Department of Cell and Molecular Biology, Tulane University, 2000 Stern Hall, 6400 Freret St, New Orleans, LA 70118, USA zzhang
    Mech Dev 120:1469-79. 2003
    ..We show that the expression of Cbfa1 and Dlx5, two genes encode transcription factors that are critical for bone differentiation, overlaps with that of Msx1 and ..
  12. ncbi Expression of Dlx5 and Dlx6 during specification of the elbow joint
    Deborah Ferrari
    Center for Regenerative Medicine and Skeletal Development, Department of Oral Rehabilitation, Biomaterials and Skeletal Development, University of Connecticut Health Center, School of Dental Medicine, Farmington, Connecticut 06030, USA
    Int J Dev Biol 50:709-13. 2006
    ..we show that during specification of the elbow joint in the chick limb bud, the homeodomain transcription factors Dlx5 and Dlx6 are highly expressed by a discrete group of cells that encompass the prospective elbow joint...
  13. doi Retinoic acid-induced inner ear teratogenesis caused by defective Fgf3/Fgf10-dependent Dlx5 signaling
    Wei Liu
    Department of Otorhinolaryngology Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Birth Defects Res B Dev Reprod Toxicol 83:134-44. 2008
    ..Retinoic acid (RA) is essential for inner ear development. However, exposure to excess RA at a critical period leads to inner ear defects. These defects are associated with disruption in epithelial-mesenchymal interactions...
  14. pmc Regulation of Dlx3 gene expression in visceral arches by evolutionarily conserved enhancer elements
    Kenta Sumiyama
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 100:4030-4. 2003
    The mammalian Distal-less (Dlx) clusters (Dlx1-2, Dlx5-6, and Dlx3-7) have a nested expression pattern in developing visceral (branchial) arches...
  15. ncbi The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway
    Giorgio R Merlo
    Dulbecco Telethon Institute DTI, Advanced Biotechnology Center, Largo R Benzi 10, 16132 Genoa, Italy
    Dev Biol 248:157-69. 2002
    In the mouse embryo, Dlx5 is expressed in the otic placode and vesicle, and later in the semicircular canals of the inner ear...
  16. ncbi Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
    Zhengshi Lin
    Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
    Development 132:2309-18. 2005
    ..fates such as the endolymphatic duct and semicircular canals by positively regulating genes such as Wnt2b and Dlx5. However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression...
  17. doi Conserved pattern of OTP-positive cells in the paraventricular nucleus and other hypothalamic sites of tetrapods
    Sylvia M Bardet
    Department of Human Anatomy and Psychobiology, and CIBERER Research Group 736 Medical School, University of Murcia, Murcia E30071, Spain
    Brain Res Bull 75:231-5. 2008
    ..nucleus abuts the prethalamus (prosomere 3), and the entire complex is flanked ventrally and dorsally by Dlx5-expressing domains of the alar plate...
  18. pmc Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear
    Min Deng
    University of Rochester Flaum Eye Institute, University of Rochester, Rochester, NY 14642, USA
    Dev Biol 338:38-49. 2010
    ..known otic markers showed that Lmo4 is essential for the normal expression of Bmp4, Fgf10, Msx1, Isl1, Gata3, and Dlx5 in the dorsolateral domain of the otocyst, whereas the initial compartmentalization of the otocyst remains ..
  19. pmc Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development
    Michael J Depew
    Department of Craniofacial Development, King s College London, Guy s Hospital, London, UK
    J Anat 207:501-61. 2005
    ..on an allelic series of Dlx loss-of-function mouse mutants that includes various combinations of Dlx1, Dlx2, Dlx3, Dlx5 and Dlx6. Although we confirm fundamental aspects of the hypothesis, we further report a number of novel findings...
  20. ncbi Dlx5- and Dlx6-mediated chondrogenesis: Differential domain requirements for a conserved function
    Shu Hsuan Claire Hsu
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ont, Canada N1G 2W1
    Mech Dev 123:819-30. 2006
    ..b>Dlx5 and Dlx6 are functionally redundant regulators of chondrocyte hypertrophy...
  21. pmc Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs
    Juhee Jeong
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Development 135:2905-16. 2008
    ..for jaw) and mutant phenotypes; inactivation of Dlx1 and Dlx2 (Dlx1/2-/-) causes defects in the upper jaw, whereas Dlx5/6(-/-) results in homeotic transformation of the lower jaw into upper jaw...
  22. ncbi Development of the facial midline
    Michael H Carstens
    Loma Linda University, Children s Hospital, Oakland, CA
    J Craniofac Surg 13:129-87; discussion 188-90. 2002
    ..4) Mutants for the Dlx5 gene demonstrate A field deletion patterns...
  23. doi Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects
    Nadia Lo Iacono
    Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
    Development 135:1377-88. 2008
    ..are known in humans; the most common (type-I) is linked to deletions of DSS1 and the distalless-related homeogenes DLX5 and DLX6...
  24. ncbi Temporospatial cell interactions regulating mandibular and maxillary arch patterning
    C A Ferguson
    Department of Craniofacial Development, GKT Dental Institute, Kings College, Guy s Hospital, London SE1 9RT, UK
    Development 127:403-12. 2000
    ..Thus, whereas both mandibular and maxillary arch epithelia could induce Dlx2 and Dlx5 expression in the mandible and Dlx2 expression in the maxilla, neither could induce Dlx5 expression in the maxilla...
  25. ncbi Hmx2 homeobox gene control of murine vestibular morphogenesis
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Development 128:5017-29. 2001
    ..The developmental regulators Bmp4, Dlx5 and Pax2 all play a critical role in inner ear ontogeny, and the expression of each of these genes is affected in ..
  26. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    ..In the canals, Bmp2 and Dlx5 are regulated by Bmp4, either directly or indirectly...
  27. doi Transcriptional regulation of bone sialoprotein gene by Porphyromonas gingivalis lipopolysaccharide
    Xinyue Li
    Department of Periodontology, Nihon University School of Dentistry at Matsudo, Chiba 271 8587, Japan
    J Cell Biochem 110:823-33. 2010
    ..ChIP assays revealed increased binding of CREB1, JunD, Fra2, Runx2, Dlx5, and Smad1 to a chromatin fragment containing the CRE and FRE by 0.01 microg/ml P. gingivalis LPS...
  28. ncbi Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
    D Acampora
    International Institute of Genetic and Biophysics, CNR, Via Marconi 10, Italy
    Development 126:3795-809. 1999
    The Dlx5 gene encodes a Distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of the mouse embryo...
  29. ncbi Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission
    Maria R Domenici
    Department of Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 26:5794-9. 2006
    ..reduced glutamatergic responses in slices obtained from mice lacking CB1 exclusively in GABAergic neurons (CB1(f/f;Dlx5/6-Cre)), thus excluding the involvement of CB1 expressed on GABAergic neurons in this effect of the drug...
  30. ncbi Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, Maine
    Genesis 44:425-37. 2006
    ..and is observed in patients with split hand/split foot malformation, a malformation which is phenocopied by Dlx5/6 null mice...
  31. ncbi Methyl CpG-binding protein 2 (a mutation of which causes Rett syndrome) directly regulates insulin-like growth factor binding protein 3 in mouse and human brains
    Masayuki Itoh
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neuropathol Exp Neurol 66:117-23. 2007
    ..These results suggest that IGFBP3 is a downstream gene regulated by MeCP2 and that the previously reported BDNF and DLX5 genes and MeCP2 may contribute directly to the transcriptional expression of IGFBP3 in the brain...
  32. ncbi Xenopus aristaless-related homeobox (xARX) gene product functions as both a transcriptional activator and repressor in forebrain development
    Daniel W Seufert
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Dev Dyn 232:313-24. 2005
    ..However, expression of some markers, dlx5 and wnt8b, was enhanced in xArx-injected embryos...
  33. ncbi Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome
    Shin ichi Horike
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 84 171, University of California, Berkeley, California 94720, USA
    Nat Genet 37:31-40. 2005
    ..Several sequences mapped to an imprinted gene cluster on chromosome 6, including Dlx5 and Dlx6, whose transcription was roughly two times greater in brains of Mecp2-null mice compared with those of ..
  34. ncbi Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins
    Takaaki Kuwajima
    Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 26:5383-92. 2006
    ..Immunohistochemical analysis revealed that necdin was coexpressed with Dlx2, Dlx5, or MAGE-D1 in a subpopulation of embryonic forebrain cells...
  35. pmc The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development
    Raymond F Robledo
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Genes Dev 16:1089-101. 2002
    ..In addition, human Dlx5 and Dlx6 homeobox genes have been identified as possible candidate genes for the autosomal dominant form of the ..
  36. ncbi Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors
    Stephen E Harris
    Department of Oral Biology, University of Missouri at Kansas City, School of Dentistry, Kansas City, MO 64108, USA
    Front Biosci 8:s1249-65. 2003
    ..The Dlx2 and Dlx5 homeobox genes have been shown to be critical for bone formation both in vitro and in vivo...
  37. ncbi Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 27:3884-93. 2007
    ..gene-targeting strategy, using Foxg1-Cre mice to delete Rac1 in the ventricular zone (VZ) of telencephalon and Dlx5/6-Cre-IRES (internal ribosomal entry site)-EGFP (enhanced green fluorescent protein) (Dlx5/6-CIE) in the ..
  38. ncbi Expression of DLX5 during human embryonic craniofacial development
    J L Davideau
    Laboratoire de Biologie Odontologie, Universite Paris VII, Paris, France
    Mech Dev 81:183-6. 1999
    ..In order to study the role of DLX genes during embryonic development in human, DLX5 expression pattern was investigated in 6- to 11-week-old human embryos...
  39. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
    Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns...
  40. pmc Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity
    Louis Bruno Ruest
    Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY 40292, USA
    Development 131:4413-23. 2004
    ..in Ednra(-/-) embryos undergo a homeotic transformation into maxillary-like structures similar to those observed in Dlx5/Dlx6(-/-) embryos, though lower incisors are still present in both mutant embryos...
  41. ncbi SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes
    Cordula Magee
    Department of Anatomy and Cellular Biology, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 280:25331-8. 2005
    ..In this sequence, a binding site for Dlx5/6 transcription factors (nt -99 to -87) retards a protein specific for hypertrophic chondrocytes in electrophoretic ..
  42. pmc A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
    ..Our results suggest that some OB interneurons are derived from progenitors outside the LGE and that precursors expressing what has classically been considered a pallial transcription factor generate GABAergic interneurons...
  43. ncbi Molecular identity of olfactory bulb interneurons: transcriptional codes of periglomerular neuron subtypes
    Zegary J Allen
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    J Mol Histol 38:517-25. 2007
    ..e. dopaminergic, calbindin- and calretinin-expressing) derive from cells that express the homeobox genes Dlx5/6...
  44. doi Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 135:755-65. 2008
    ..the Edn1/Ednra signaling is thought to regulate the dorsoventral axis patterning of pharyngeal arches via Dlx5/Dlx6 upregulation...
  45. doi The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter
    Luc J Martin
    Reproduction, Perinatal and Child Health, CHUQ Research Centre, CHUL Room T1 49, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    J Mol Endocrinol 42:119-29. 2009
    ..These include the nuclear receptors NUR77 and SF1, AP-1 family members (particularly c-JUN), GATA4, C/EBPbeta, DLX5/6, and CREB...
  46. pmc Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females
    Eric Marsh
    Abramson Research Center, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Brain 132:1563-76. 2009
    ..To directly test this possibility, mice carrying a floxed Arx allele were generated and crossed to Dlx5/6(CRE-IRES-GFP)(Dlx5/6(CIG)) mice, conditionally deleting Arx from ganglionic eminence derived neurons including ..
  47. doi cAMP and fibroblast growth factor 2 regulate bone sialoprotein gene expression in human prostate cancer cells
    Zhengyang Li
    Department of Periodontology, Nihon University School of Dentistry at Matsudo, Chiba 271 8587, Japan Tianjin Stomatology Hospital, Tianjin, China
    Gene 471:1-12. 2011
    ..were supershifted by phospho-CREB1 and c-Fos antibodies, and disrupted by CREB1, c-Jun, JunD, Fra2, p300, Runx2, Dlx5 and Smad1 antibodies...
  48. ncbi Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development
    M A Crackower
    Department of Molecular and Medical Genetics, University of Toronto, Canada
    Hum Mol Genet 5:571-9. 1996
    ..Three genes were identified, two genes of the Distal-less (dii) homeobox gene family, DLX5 and DLX6 and a novel gene, which we named DSS1...
  49. ncbi Multiple functions of Dlx genes
    G R Merlo
    Laboratory of Molecular Morphogenesis, National Cancer Institute IST, Genova, Italy
    Int J Dev Biol 44:619-26. 2000
    ..In addition, Dlx5 and Dlx6 are expressed in differentiating osteoblasts...
  50. pmc Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters
    Noel Ghanem
    Ottawa Health Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Genome Res 13:533-43. 2003
    ..The Dlx1/Dlx2, Dlx5/Dlx6, and Dlx3/Dlx7 clusters likely originate from duplications of an ancestral Dlx gene pair...
  51. ncbi Segregation of lens and olfactory precursors from a common territory: cell sorting and reciprocity of Dlx5 and Pax6 expression
    Sujata Bhattacharyya
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 271:403-14. 2004
    ..b>Dlx5 and Pax6 are initially co-expressed by future lens and olfactory cells...
  52. pmc Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh
    Martin M Riccomagno
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 19:1612-23. 2005
    ..signaling is active in dorsal regions of the otic vesicle, where it functions to regulate the expression of genes (Dlx5/6 and Gbx2) necessary for vestibular morphogenesis...
  53. ncbi Dlx3 is expressed in the ventral forebrain of chicken embryos: implications for the evolution of the Dlx gene family
    Hui Zhu
    Department of Molecular and Cellular Biology, University of Guelph, Ontario, Canada
    Int J Dev Biol 50:71-5. 2006
    The archetypal genomic arrangement of vertebrate Dlx genes is as three bigene clusters (Dlx1/2, Dlx3/4, Dlx5/6)...
  54. ncbi Cellular patterns of transcription factor expression in developing cortical interneurons
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
    Cereb Cortex 16:i82-8. 2006
    ..differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB)...
  55. ncbi Rett syndrome
    Bruria Ben Zeev Ghidoni
    Pediatric Neurology Unit, Safra Pediatric Hospital, Sheba Medical Center, Ramat Gan, Israel
    Child Adolesc Psychiatr Clin N Am 16:723-43. 2007
    ..including MeCP2 protein levels in autistic brains and MeCP2 effects on genes connected to autism, like DLX5 and genes on 15q11-13 region. This area also is involved in Angelman syndrome, which has many similarities to RS...
  56. pmc Gene expression in cortical interneuron precursors is prescient of their mature function
    Renata Batista-Brito
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Building, New York University Medical Center, 522 First Avenue, New York, NY 10016, USA
    Cereb Cortex 18:2306-17. 2008
    ..a gene expression microarray analysis on cortical interneuron precursors isolated through their expression of a Dlx5/6(Cre-IRES-EGFP) transgene. We purified these precursors from the embryonic mouse neocortex at E13.5 and E15...
  57. doi Ubc9 promotes the stability of Smad4 and the nuclear accumulation of Smad1 in osteoblast-like Saos-2 cells
    Koichi Shimada
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Bone 42:886-93. 2008
    ..The expression of BMP-induced transcription factors, including Runx2, Dlx5, Msx2, and Osterix, was examined using real-time reverse transcription polymerase chain reaction (qRT-PCR), and the ..
  58. doi Isolation and imprinting analysis of the porcine DLX5 gene and its association with carcass traits
    H C Cheng
    Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China
    Anim Genet 39:395-9. 2008
    ..In this study, the complete ORF containing 289 amino acids of the porcine DLX5 gene was obtained...
  59. pmc Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis
    Mohammad Q Hassan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Cells Tissues Organs 189:122-5. 2009
    ..Our studies provide evidence for (1) selective association of HOXA10, MSX2, DLX3 and DLX5 homeodomain transcription factors on Runx2 and OC genes at stages of osteoblast maturation as well as (2) ..
  60. pmc 5-Azacytidine facilitates osteogenic gene expression and differentiation of mesenchymal stem cells by alteration in DNA methylation
    Guo Shun Zhou
    Key Laboratory of Molecular Medicine, Huzhou Central Hospital, 313100, Huzhou, Zhejiang, People s Republic of China
    Cytotechnology 60:11. 2009
    ..Taking dlx5 as a representative, methylation alterations of the "CpG island shore" in the promoter caused by 5-azacytidine ..
  61. pmc Molecular regulation of matrix extracellular phosphoglycoprotein expression by bone morphogenetic protein-2
    Young Dan Cho
    Department of Cell and Developmental Biology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110 749, Korea
    J Biol Chem 284:25230-40. 2009
    ..Overexpression and knock-down experiments of Smads, Dlx5, and Runx2 indicated that they are indispensable mediators of BMP-2-induced Mepe expression...
  62. doi Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts
    Koichi Shimada
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    Biochem Biophys Res Commun 390:775-9. 2009
    ..in the medium, the expression levels of the Bmp2 gene and BMP-induced transcription factor genes, including Runx2, Dlx5, Msx2, and Sp7, and the phosphorylated-Smad1 protein level were increased in cells transfected with Traf2 siRNA...
  63. doi Polymethylmethacrylate particles impair osteoprogenitor viability and expression of osteogenic transcription factors Runx2, osterix, and Dlx5
    Richard Chiu
    Department of Orthopaedic Surgery, Stanford University Medical Center, 300 Pasteur Drive, Edwards Building, R 116, Stanford, California 94305 5341, USA
    J Orthop Res 28:571-7. 2010
    ..the effects of these materials on osteoprogenitor viability and expression of transcription factors Runx2, osterix, Dlx5, and Msx2...
  64. pmc Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    BMC Musculoskelet Disord 11:104. 2010
    ..factors are involved in the establishment and maintenance of the osteoblastic phenotype, such as Runx2, osterix and Dlx5. The transcription factor retinoblastoma binding protein-1 (RBP1) was recently identified as an estrogen regulated ..
  65. doi AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells
    Won Gu Jang
    Department of Pharmacology and Dental Therapeutics and BK21, School of Dentistry, Chonnam National University, Gwangju 500 757, Republic of Korea
    Biochem Biophys Res Commun 404:1004-9. 2011
    ..In addition, metformin induced the phosphorylation of Smad1/5/8 and expression of Dlx5 and Runx2, whereas compound C or dominant negative AMPK inhibited these effects...
  66. pmc Restricted transgene expression in the brain with cell-type specific neuronal promoters
    Aurélie Delzor
    Atomic Energy Commission CEA, Institute of Biomedical Imaging I2BM and Molecular Imaging Research Center MIRCen, 92265 Fontenay aux Roses, France
    Hum Gene Ther Methods 23:242-54. 2012
    ..The promoters with the highest activity were those of the 67 kDa glutamic acid decarboxylase (GAD67), homeobox Dlx5/6, glutamate receptor 1 (GluR1), and preprotachykinin 1 (Tac1) genes...
  67. pmc Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes
    Emily G Berghoff
    Developmental Biology and Department of Pediatrics, Lurie Children s Research Center, and Feinberg School of Medicine, Northwestern University, Box 204, 2430 N Halsted, Chicago, IL 60614, USA
    Development 140:4407-16. 2013
    ..through Dlx6 antisense (Dlx6as) transcription and methyl-CpG binding protein (MECP2) recruitment to the Dlx5/6 ultraconserved DNA regulatory enhancer (Dlx5/6ei) in embryonic day 13.5 medial ganglionic eminence (E13.5 MGE)...
  68. doi Optimizing the osteogenic differentiation of human mesenchymal stromal cells by the synergistic action of growth factors
    Yahya Acil
    Department of Oral and Maxillofacial Surgery, Christian Albrechts University, Kiel, Germany
    J Craniomaxillofac Surg 42:2002-9. 2014
    ..upregulation of collagen type I, collagen type V, osteocalcin, alkaline phosphatase, RUNX2, BMP-2, osteonectin and DLX5 (p < 0.01) and resulted in a consistent matrix mineralization...
  69. doi Bioactive borate glass promotes the repair of radius segmental bone defects by enhancing the osteogenic differentiation of BMSCs
    Jieyuan Zhang
    Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, People s Republic of China Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, People s Republic of China These authors contributed equally
    Biomed Mater 10:065011. 2015
    ..Mechanistically, the critical genes Smad1/5 and Dlx5 in the BMP pathway and p-Smad1/5 proteins were significantly elevated after BG transplantation, and these effects ..
  70. pmc Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain
    Louis Bruno Ruest
    Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Kentucky 40292, USA
    Genesis 37:188-94. 2003
    b>Dlx5 and Dlx6, two members of the Distalless gene family, are required for development of numerous tissues during embryogenesis, including facial and limb development...
  71. ncbi Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2
    Youn Jeong Kim
    Department of Biochemistry, School of Dentistry and Skeletal Diseases Genome Research Center, Kyungpook National University, Daegu 700 422, Korea
    J Biol Chem 279:50773-80. 2004
    ..by bone morphogenetic protein (BMP)-2 treatment, the activation of BMP receptors and R-Smads, and the expression of Dlx5 and Runx2. However, how BMP-2 induces ALP expression is not clearly understood...
  72. ncbi Rett syndrome and neuronal development
    Michael V Johnston
    Department of Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Child Neurol 20:759-63. 2005
    ..that MeCP2 controls the expression of brain-derived neurotrophic factor and the DNA-binding homeobox protein Dlx5. Brain-derived neurotrophic factor enhances glutamate neurotransmission at excitatory synapses, whereas Dlx5 is ..
  73. pmc Phenotypic analysis of Dlx5 overexpression in post-natal bone
    J Zhang
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 87:45-50. 2008
    b>Dlx5 plays an important role in the embryonic development of mineralized tissues. We hypothesized that Dlx5 also functions in regulating post-natal bone formation in mice...
  74. pmc Netrin-1-alpha3beta1 integrin interactions regulate the migration of interneurons through the cortical marginal zone
    Amelia Stanco
    University of North Carolina Neuroscience Center and Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 106:7595-600. 2009
    ..In vivo analysis of interneuron-specific alpha3beta1 integrin, netrin-1-deficient mice (alpha3(lox/-)Dlx5/6-CIE, netrin-1(-/-)) reveals specific deficits in the patterns of interneuronal migration along the top of the ..
  75. doi Selective isolation and differentiation of a stromal population of human embryonic stem cells with osteogenic potential
    Linda Harkness
    Department of Endocrinology and Metabolism, Laboratory for Molecular Endocrinology KMEB, Medical Biotechnology Centre MBC, Winsløwparken 25, University of Southern Denmark, 5000 Odense C, Denmark
    Bone 48:231-41. 2011
    ..When cultured in osteogenic differentiation media, up regulation of osteoblastic lineage markers (DLX5, MSX2, RUNX2, SPARC, ALP, COL1a1, BGLAP, IBSP, DCN, LOX-L4) and production of in vitro mineralized matrix was ..
  76. pmc FGF signaling transforms non-neural ectoderm into neural crest
    Nathan Yardley
    Department of Molecular, Cellular, and Developmental Biology, KBT 1100, Yale University, P O Box 208103, New Haven, CT 06520 8103, USA
    Dev Biol 372:166-77. 2012
    ..in response to FGF the non-neural ectoderm can ectopically express several early neural crest markers (Pax7, Msx1, Dlx5, Sox9, FoxD3, Snail2, and Sox10)...
  77. doi High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix
    Erica G Tierney
    Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Control Release 165:173-82. 2013
    ..the GAMs which revealed no significant changes in runx2 or BMP2 expression but an upregulation of osterix (Osx) and Dlx5 expression prompting the belief that the mode of osteogenesis is independent of the BMP2 pathway...
  78. ncbi A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction
    K Miyama
    New Product Research Laboratories III, Daiichi Pharmaceutical Co, Ltd, Tokyo R and D Center, Kita Kasai, Edogawa ku, Tokyo, 134, Japan
    Dev Biol 208:123-33. 1999
    ..These findings suggest that mDlx5 is a target gene of the BMP signaling pathway and acts as an important regulator of both osteogenesis and dorsoventral patterning of embryonic axis...
  79. ncbi Dlx5 induces expression of COL1A1 promoter contained in a retrovirus vector
    T Tadic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington CT 06030, USA
    Croat Med J 42:436-9. 2001
    To determine whether retrovirally expressed Dlx5, a homeobox-containing transcription factor, can induce a 2.3 kb rat COL1A1 promoter-reporter construct, which is transduced into osteoblastic cells by the use of a retrovirus vector.
  80. ncbi Transcriptional regulation restricting bone sialoprotein gene expression to both hypertrophic chondrocytes and osteoblasts
    George L Barnes
    Orthopaedic Research Laboratory of the Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Cell Biochem 87:458-69. 2002
    ..While Dlx5 has been implicated as the tissue-specific regulator of BSP expression through direct DNA binding at an element ..
  81. ncbi Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: mirror of the past?
    Annemiek Beverdam
    Laboratory of Molecular Morphogenesis, National Institute for Cancer Research, Genova, Italy
    Genesis 34:221-7. 2002
    ..Here we show that simultaneous inactivation of the murine homeobox genes Dlx5 and Dlx6 results in the transformation of the lower jaw into an upper jaw and in symmetry of the snout...
  82. ncbi Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis
    Jan Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 23:167-74. 2003
    ..Moreover, the adult SVZ and RMS contain numerous Er81-positive cells. Fate-mapping studies using Dlx5/6-cre transgenic mice demonstrate that Er81-positive cells in the granule cell and glomerular layers of the ..
  83. ncbi BMP signals regulate Dlx5 during early avian skull development
    Nicolas Holleville
    Institut d Embryologie Cellulaire et Moleculaire, CNRS, UMR 7128, 49 bis, avenue de la Belle Gabrielle, 94736, Nogent sur Marne, France
    Dev Biol 257:177-89. 2003
    ..b>Dlx5 gene mutation leads to cranial dismorphogenesis which differs from the previously studied craniosynostosis ..
  84. ncbi Effects of bone morphogenetic protein-2 and transforming growth factor beta1 on gene expression of transcription factors, AJ18 and Runx2 in cultured osteoblastic cells
    Minoru Takagi
    Department of Anatomy, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    J Mol Histol 35:81-90. 2004
    Osteoblast differentiation is controlled by multiple transcription factors, Runx2, AJ18, Osterix, Dlx5 and Msx2...
  85. ncbi Dlx5, the mouse homologue of the human-imprinted DLX5 gene, is biallelically expressed in the mouse brain
    Motoshi I Kimura
    Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishimachi, Yonago 683 8503, Japan
    J Hum Genet 49:273-7. 2004
    The mouse Dlx5 gene encodes a distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of mouse embryo and is located on chromosome 6, which is the syntenic region to the ..
  86. pmc Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene
    Mohammad Q Hassan
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655 0106, USA
    Mol Cell Biol 24:9248-61. 2004
    Genetic studies show that Msx2 and Dlx5 homeodomain (HD) proteins support skeletal development, but null mutation of the closely related Dlx3 gene results in early embryonic lethality...
  87. ncbi Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene
    Hernan Roca
    Department of Periodontics, Prevention, and Geriatrics and Center for Craniofacial Regeneration, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Biol Chem 280:30845-55. 2005
    ..All three sites (R1, R2, and C) are necessary for maximal promoter activity in osteoblasts. DLX5 in MC-4 cell nuclear extracts binds to the C site in vitro...
  88. ncbi Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells
    Hyun Mo Ryoo
    Department of Biochemistry, School of Dentistry and Skeletal Diseases Genome Research Center, Kyungpook National University, Daegu 700 422, South Korea
    Gene 366:51-7. 2006
    ..R-Smad activation, and kinase activation, and the role of osteogenic transcription factors, such as Runx2, Osx, Dlx5, and Msx2...
  89. ncbi Effects of low-intensity pulsed ultrasound on the differentiation of C2C12 cells
    Kyoko Ikeda
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    Life Sci 79:1936-43. 2006
    ..LIPUS stimulation, mRNA expression of cellular phenotype-specific markers characterizing osteoblasts (Runx2, Msx2, Dlx5, AJ18), chondroblasts (Sox9), myoblasts (MyoD), and adipocytes (C/EBP, PPARgamma) was studied using real-time ..
  90. ncbi Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme
    Nicolas Holleville
    CNRS UMR 7128, Institut d Embryologie Cellulaire et Moleculaire, 94736 Nogent sur Marne, France
    Dev Biol 304:860-74. 2007
    ..Here, we address the role of the homeobox transcription factor Dlx5 during the initial steps of calvaria membranous differentiation and we show that Dlx5 elicits Runx2 induction and ..
  91. ncbi The role of Dlx homeogenes in early development of the olfactory pathway
    Giorgio R Merlo
    Dulbecco Telethon Institute, CNR ITB Milano, Via F lli Cervi 93, 20090 Segrate, Milano, Italy
    J Mol Histol 38:347-58. 2007
    ..Little is known about the genetic control of intrinsic ORN properties. Inactivation of the distalless-related Dlx5 prevents connections between ORNs and FB...
  92. ncbi Genomic deletion size at the epsilon-sarcoglycan locus determines the clinical phenotype
    Friedrich Asmus
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany
    Brain 130:2736-45. 2007
    ..M-D, whereas one paediatric patient with split-hand/split-foot malformation and sensorineural hearing loss (SHFM1D, OMIM 220600) had not developed M-D at the age of 9 years. This patient had the largest deletion of 8.78 Mb (7q21...
  93. pmc Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development
    Margarita García-López
    Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
    J Comp Neurol 506:46-74. 2008
    ..analyzed the distribution of key regulatory genes that show restricted expression patterns within the subpallium (Dlx5, Nkx2...
  94. doi Bone morphogenetic protein-2 induces the differentiation of a mesenchymal progenitor cell line, ROB-C26, into mature osteoblasts and adipocytes
    Shigeyuki Kato
    Department of Anatomy, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    Life Sci 84:302-10. 2009
    ....
  95. pmc Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice
    Roman A Timakhov
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Genes Chromosomes Cancer 48:786-94. 2009
    ..The inv(6) results in robust upregulation of the homeobox/transcription factor gene Dlx5 because of its relocation near the Tcrb enhancer...
  96. pmc Characterization of conserved and nonconserved imprinted genes in swine
    Steve R Bischoff
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina 27606, USA
    Biol Reprod 81:906-20. 2009
    ..We also found no evidence of imprinting in ASB4, ASCL2, CD81, COMMD1, DCN, DLX5, and H13. Combined, these results represent the most comprehensive survey of imprinted genes in swine to date.
  97. doi Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2
    Hyang Kim
    Medical Science Graduated School, Yonsei University College of Medicine, Seoul, Korea
    Spine (Phila Pa 1976) 34:1834-8. 2009
    ..In vitro experiment using bone morphogenetic protein-2 (BMP-2) and cells from the nucleus pulposus (NP), transitional zone (TZ), and anulus fibrosus (AF) of the human intervertebral disc (IVD)...
  98. doi Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism
    Bart L T Vaes
    Division of Human Nutrition, Wageningen University and Research Centre, Wageningen, The Netherlands
    Bone 46:514-23. 2010
    ..Gene expression analysis of early (Msx2, Dlx5, Runx2) and late (Alp, Osx, Ocn) osteoblast markers during bone morphogenetic protein 2-induced C2C12 osteoblast ..
  99. doi The effects of COX-2 inhibitor during osteogenic differentiation of bone marrow-derived human mesenchymal stem cells
    Dong Suk Yoon
    Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, South Korea
    Stem Cells Dev 19:1523-33. 2010
    ..The mRNA expression of Runx2/Cbf alpha 1, Dlx5, and osteocalcin was also decreased by COX-2 inhibitors in inflammatory-conditioned MSCs and showed a significant ..
  100. doi Deficiency of vitamin A delays bone healing process in association with reduced BMP2 expression after drill-hole injury in mice
    Kazuhiro Tanaka
    Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Bone 47:1006-12. 2010
    ..During repair of the bone defect, increases of bmp2, dlx5, msx2, col1a1, and osteocalcin mRNA expression were suppressed, and runx2-p2 mRNA expression was accelerated in VAD...
  101. pmc Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling
    Yinfei Tan
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 70:9197-206. 2010
    ..We had previously found that Dlx5 is overexpressed in an Akt2 transgenic model of T-cell lymphoma...

Research Grants32

  1. The Role of Osteoactivin in Osteoblast Development and Function
    Fayez F Safadi; Fiscal Year: 2013
    ..We present preliminary data that BMP2 stimulates the recruitment of Smad1, Dlx5 and CBP to the OA promoter and this effect is dependent on the stage of osteoblast differentiation...
  2. Cun Yu Wang; Fiscal Year: 2016
    ..Aim 1 is to determine whether KDM4B epigenetically regulate MSC lineage commitment through induction of DLX5. Aim 2 is to explore how erasing H3K9me3 by KDM4B coordinately regulates osteogenic differentiation of MSCs...
  3. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    Joseph R Testa; Fiscal Year: 2013
    ..Up regulation of one of these candidate genes, encoding the transcription factor Dlx5, has recently been reported in several common human cancers, suggesting that this homeobox gene may be oncogenic ..
  4. Molecular and Genetic Regulation of Craniofacial Development
    Brian L Black; Fiscal Year: 2013
    ..Mice that carry one mutant allele of Dlx5/6 locus and one mutant copy of the Mef2c allele die at birth from craniofacial defects resembling PRS...
  5. Richard A Schneider; Fiscal Year: 2016
    ..the Transforming Growth Factor-Beta (TGF[unreadable]) and Bone Morphogenetic Protein (BMP) pathways such as Runx2, Dlx5, and Msx1, since they are known to affect osteogenesis and their expression is altered in chimeras...
  6. Lisa J Bain; Fiscal Year: 2014
    ..plate border specifier cells, which express transcription factors involved in myogenesis, such as Pax3, Pax7, Dlx5, Msx1, and Msx2, and are responsible for secreting factors that lead to the formation of the neural crest specifier ..
  7. John L R Rubenstein; Fiscal Year: 2016
    ..g.GucylaS, Zfhxib and cMaf);definiting interneuron phenotypes of conditional DIxl, Dlx2, Dlx1/Dlx2 and Dlx5 mutants;and characterizing autism mutant alleles of Dlx2, Lhx6 and other regulators of interneurons using an MGE-..
  8. JHUMKU DUTT KOHTZ; Fiscal Year: 2016
    ..We show that Evf2 forms a complex with the DLX2 homeodomain transcription factor and regulates Dlx5/6 enhancer activity...
  9. The role of Foxi3 in inner ear development
    SAFIA BANO KHATRI; Fiscal Year: 2012
    ..The PPR is marked by the expression of unique set of genes like Dlx5, ERNI, Six1/4, Foxi3 and Eya 1/2. We have shown that Foxi3 is one of the earliest genes expressed in this region...
  10. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
    ..The genetic units to identify cell of the articular lineage will include: pre-interzone cells, Dlx5 and Col2a1;interzone cells, Gdf5;early articular chondrocytes, Pg4 (lubricin) and mature articular cells, tnc (..
  11. The Role of FoxP2 in Olfactory Bulb Interneuron Neurogenesis
    Zegary J Allen; Fiscal Year: 2010
    ..Furthermore, the transcription factors Dlx5/6 have been shown to be expressed in cells that will give rise to olfactory bulb interneurons...
  12. Role of Dlx-5 in Chondrocyte Differentiation
    ROBERT KOSHER; Fiscal Year: 2007
    ..The goal of this research is to investigate the hypothesis that the homeodomain transcription factor Dlx5 is a key positive regulator of chondrocyte maturation during endochondral ossification, and to unravel the ..
  13. Dix Genes in Neurogenic Cranial Placode Induction
    Stephen Brown; Fiscal Year: 2004
    ..A number of genes, including Dlx5 and Dlx6, are expressed in a pattern marking the pre-placodal ectoderm, however their roles in placode induction ..
  14. DLX HOMEOBOX GENE CONTROL OF FETAL SKELETOGENESIS
    Thomas Lufkin; Fiscal Year: 2004
    ..domains and the preliminary results from the Principal Investigator's gene knockout studies presented below, the Dlx5 and Dlx6 homeobox genes are major directors of morphogenesis and cellular differentiation of the fetal skeleton...
  15. Regulation of craniofacial development by the Dix genes.
    John Rubenstein; Fiscal Year: 2007
    ..as well as the olfactory and otic appatati We have made loss-of-function mutations of Dlxl, Dlx2, Dlxl&2 and Dlx5 in the mouse and found that these genes are essential for normal skeletal morphogenesis of the jaw apparatus and ..
  16. iCys Laser Scanning Cytometer for UC Davis Core
    Janine LaSalle; Fiscal Year: 2008
    ..The placement of a shared iCys LSC imaging system in a core facility with a strong track record of support is a cost effective way of supporting NIH funded researchers at UC Davis. [unreadable] [unreadable] [unreadable]..
  17. Epigenetic Interaction of MECP2 and Organic Pollutants in Neurodevelopment
    Janine LaSalle; Fiscal Year: 2009
    ..factors in the etiology of autism and mental retardation? Can specific epigenetic changes be diagnostic for autism and mental retardation of unknown genetic etiology? Are epigenetic changes affecting neurodevelopment heritable? ..
  18. Epigenetic Etiologies of Autism-Spectrum Disorders
    Janine LaSalle; Fiscal Year: 2009
    ..The successful completion of these studies should yield findings to help develop better diagnostic and treatment modalities for autism-spectrum disorders. ..
  19. Altered Inhibitory Prefrontal Circuitry in Schizophrenia
    DAVID VOLK; Fiscal Year: 2003
    ..After a 3 month survival period, we will quantify any changes in the mRNA expression of PFC GABA markers using in situ hybridization and grain counting techniques. ..
  20. Pharmacogenomics of Antidepressant Response
    Steven Hamilton; Fiscal Year: 2008
    ..These findings could provide steps toward our ability to define clinically useful genetic predictors of pharmacological treatment and apply them to patient populations. ..
  21. Bone Strength Phenotypes in men: Genes and Environment
    Joseph Zmuda; Fiscal Year: 2008
    ..The improved understanding of the genetic regulation of bone strength that will emerge from the proposed project will yield fundamental insight into the basic mechanisms of male osteoporosis. ..
  22. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Genetic Determinants of COMT Expression
    Steven Hamilton; Fiscal Year: 2007
    ..This in vitro work may be useful for the understanding of the genetic contribution of COMT to disease susceptibility, particularly with regard to the cis regulation of the COMT locus. [unreadable] [unreadable] [unreadable]..
  24. Hearing loss associated with chromosomal rearrangements
    Kerry Kocher; Fiscal Year: 2007
    ..Analysis of the mice and in situ hybridization studies of the candidate genes in the cochlea will be used to establish the role of these genes in auditory function. ..
  25. Mechanically Responsive Regions of MEPE Gene
    JELICA HEINRICH; Fiscal Year: 2006
    ..This approach should enhance our understanding of the complex signaling pathways involved in bone response to mechanical loading. [unreadable] [unreadable]..
  26. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
    ..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
  27. Determinants of Bone Strength in Afro-Caribbean Families
    Joseph Zmuda; Fiscal Year: 2004
    ..The identification of these genes will likely yield fundamental insight on bone biology and may lead to the development of novel approaches to the diagnosis, treatment, and prevention of osteoporosis. ..
  28. ACTIVITY-DEPENDENT PLASTICITY IN SENSORY CORTEX
    Edward Jones; Fiscal Year: 2004
    ....
  29. BONE SIALOPROTEIN: EXPRESSION & ROLE IN MINERALIZATION
    Renny Franceschi; Fiscal Year: 2004
    ..Such knowledge is essential for designing new strategies for bone regeneration to treat trauma and pathological conditions such as osteoporosis and periodontal disease. ..
  30. DEVELOPMENT OF THE CORTICOTHALAMIC SYSTEM
    Edward Jones; Fiscal Year: 2003
    ..Defective maturation may be a concomitant of or a basis for certain forms of seizures in young individuals. ..