DR5

Summary

Gene Symbol: DR5
Description: TNF receptor superfamily member 10b
Alias: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, tumor necrosis factor receptor superfamily member 10B, Fas-like protein, TNF-related apoptosis-inducing ligand receptor 2, apoptosis inducing protein TRICK2A/2B, apoptosis inducing receptor TRAIL-R2, cytotoxic TRAIL receptor-2, death domain containing receptor for TRAIL/Apo-2L, death receptor 5, p53-regulated DNA damage-inducible cell death receptor(killer), tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor-like protein ZTNFR9
Species: human

Top Publications

  1. pmc Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
    Lauren Clancy
    Department of Pathology, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, 01655, USA
    Proc Natl Acad Sci U S A 102:18099-104. 2005
  2. ncbi Two distinct transport motifs in the adenovirus E3/10.4-14.5 proteins act in concert to down-modulate apoptosis receptors and the epidermal growth factor receptor
    Annette Hilgendorf
    Gene Centre of the Ludwig Maximilians University, Department of Virology, 81377 Munich, Germany
    J Biol Chem 278:51872-84. 2003
  3. ncbi Identification and characterization of a new member of the TNF family that induces apoptosis
    S R Wiley
    Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Immunity 3:673-82. 1995
  4. ncbi An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Science 277:815-8. 1997
  5. ncbi Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
    J P Sheridan
    Department of Molecular Oncology, Genentech, South San Francisco, CA 94080 4918, USA
    Science 277:818-21. 1997
  6. ncbi TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL
    G R Screaton
    Molecular Immunology Group Institute of Molecular Medicine John Radcliffe Hospital Oxford, OX3 9DS, UK
    Curr Biol 7:693-6. 1997
  7. ncbi Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL
    M MacFarlane
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:25417-20. 1997
  8. ncbi KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
    G S Wu
    Nat Genet 17:141-3. 1997
  9. ncbi Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway
    P M Chaudhary
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Immunity 7:821-30. 1997
  10. ncbi TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    Immunity 7:831-6. 1997

Research Grants

  1. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
  2. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
  3. DEVELOPMENT AND FUNCTION OF INTESTINAL LYMPHOID TISSUES
    Rodney D Newberry; Fiscal Year: 2013
  4. Understanding the role of IL-10 in acute murine cytomegalovirus infection
    Pamela J Gaddi; Fiscal Year: 2010
  5. Biochemical Characterization of the Regulatory T-cell Protein LAG-3.
    Zarixia Zavala Ruiz; Fiscal Year: 2010
  6. Patricia E Molina; Fiscal Year: 2014
  7. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2010
  8. Joyce C Solheim; Fiscal Year: 2014
  9. Mitchell Kronenberg; Fiscal Year: 2015
  10. Molecular Mechanisms of HIV Disease Pathogenesis
    Kathleen L Collins; Fiscal Year: 2013

Detail Information

Publications565 found, 100 shown here

  1. pmc Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
    Lauren Clancy
    Department of Pathology, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, 01655, USA
    Proc Natl Acad Sci U S A 102:18099-104. 2005
    ..We propose that TR4 is a "regulatory" rather than "decoy" receptor that inhibits apoptosis signaling by TRAIL through this previously uncharacterized ligand-independent mechanism...
  2. ncbi Two distinct transport motifs in the adenovirus E3/10.4-14.5 proteins act in concert to down-modulate apoptosis receptors and the epidermal growth factor receptor
    Annette Hilgendorf
    Gene Centre of the Ludwig Maximilians University, Department of Virology, 81377 Munich, Germany
    J Biol Chem 278:51872-84. 2003
    ..Thus, two distinct transport motifs present in two proteins synergize for efficient target removal and immune evasion...
  3. ncbi Identification and characterization of a new member of the TNF family that induces apoptosis
    S R Wiley
    Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Immunity 3:673-82. 1995
    ..Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformed cell lines of diverse origin...
  4. ncbi An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Science 277:815-8. 1997
    ..Another death domain-containing receptor for TRAIL (designated as death receptor-5), which preferentially engaged a FLICE (caspase-8)-related death protease, was also identified...
  5. ncbi Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
    J P Sheridan
    Department of Molecular Oncology, Genentech, South San Francisco, CA 94080 4918, USA
    Science 277:818-21. 1997
    ..Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4...
  6. ncbi TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL
    G R Screaton
    Molecular Immunology Group Institute of Molecular Medicine John Radcliffe Hospital Oxford, OX3 9DS, UK
    Curr Biol 7:693-6. 1997
    ..We have cloned a new member of this family, TRICK2, the TRAIL (TNF-related apoptosis-inducing ligand) receptor inducer of cell killing 2...
  7. ncbi Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL
    M MacFarlane
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:25417-20. 1997
    ..a cytoplasmic "death domain" necessary for induction of apoptosis and is hence designated death receptor-5 (DR5). Like DR4, DR5 engages the apoptotic pathway independent of the adaptor molecule FADD/MORT1...
  8. ncbi KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
    G S Wu
    Nat Genet 17:141-3. 1997
  9. ncbi Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway
    P M Chaudhary
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Immunity 7:821-30. 1997
    ..We have isolated a new member of the tumor necrosis factor receptor (TNFR) family, designated DR5, which bears a high degree of sequence homology to DR4...
  10. ncbi TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    Immunity 7:831-6. 1997
    TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes...
  11. ncbi FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
    M R Sprick
    Tumor Immunology Program, German Cancer Research Center DKFZ Heidelberg
    Immunity 12:599-609. 2000
    ..FADD/MORT1- and caspase-8-deficient Jurkat cells expressing only TRAIL-R2 were resistant to TRAIL-induced apoptosis. Thus, FADD/MORT1 and caspase-8 are essential for apoptosis induction via TRAIL-R2...
  12. ncbi Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain
    Jan Dorr
    Department of Neurology, Division of Neuroimmunology, Charité Neuroscience Research Center, 10098 Berlin, Germany
    J Neurosci 22:RC209. 2002
    ..Conversely, this death receptor-ligand system might well play an important role in T cell-mediated autoimmune diseases of the CNS such as multiple sclerosis...
  13. ncbi TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis
    Kimihisa Ichikawa
    Biomedical Research Laboratories, Sankyo Company, Limited, Tokyo, Japan
    J Immunol 171:1061-9. 2003
    ..Using two agonistic mAbs specific for TRAIL-R1 (DR4) and TRAIL-R2 (DR5), we examined the expression and function of these death receptors in RA synovial fibroblast cells...
  14. ncbi Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1
    Hajime Higuchi
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 279:51-60. 2004
    Bile acids up-regulate death receptor 5 (DR5)/TRAIL-receptor 2 (TRAIL-R2) expression thereby sensitizing hepatocytes to TRAIL-mediated apoptosis...
  15. ncbi Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 23:2554-8. 2004
    ..Here, we report that proteasome inhibitor MG132 upregulates Apo2L/TRAIL death receptor 5 expression in both Bax-proficient and -deficient HCT116 cells...
  16. ncbi Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD
    Lance R Thomas
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Medical Center Blvd Winston Salem, North Carolina 27157, USA
    J Biol Chem 279:32780-5. 2004
    ..Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signals apoptosis through two receptors, DR4 and DR5. Although there is much interest in TRAIL, the mechanism by which FADD is recruited to the TRAIL receptors is not ..
  17. ncbi IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC
    Madhu Ramaswamy
    Department of Microbiology and Immunology, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    Oncogene 23:6083-94. 2004
    ..and immunoprecipitation studies showed that IG20 can interact with TRAIL death receptors (DR), DR4 and DR5 and increase recruitment of FADD and caspase-8 into the TRAIL death-inducing signaling complex (DISC)...
  18. ncbi CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
    Hirohito Yamaguchi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 279:45495-502. 2004
    ..We and others have reported previously that DR5 expression is up-regulated in thapsigargin (THG)-treated human cancer cells...
  19. ncbi The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation
    Lance R Thomas
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 279:52479-86. 2004
    ..superfamily of receptors such as Fas/CD95 and the TNF-related apoptosis-inducing ligand (TRAIL) receptors DR4 and DR5 induce apoptosis by recruiting adaptor molecules and caspases...
  20. ncbi Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling
    Robert F Kelley
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 280:2205-12. 2005
    ..Apo2L/TRAIL is a homotrimeric protein that interacts with five receptors: death receptor 4 (DR4) and DR5 mediate apoptosis activation, whereas decoy receptor 1 (DcR1), DcR2, and osteoprotegerin counteract this function...
  21. ncbi Following a TRAIL: update on a ligand and its five receptors
    Fiona C Kimberley
    Department of Medicine, Hammersmith Hospital, Imperial College, Du Cane Road, London, UK
    Cell Res 14:359-72. 2004
    ..This review takes a comprehensive look at the story of this enigmatic ligand, addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves...
  22. pmc Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis
    A Hague
    Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK
    Br J Cancer 92:736-42. 2005
    ....
  23. ncbi Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
    Konstantinos G Drosopoulos
    Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    J Biol Chem 280:22856-67. 2005
    ..is able to kill specific tumor cells through the engagement of its receptors, death receptor 4 (DR4) and death receptor 5 (DR5), and the activation of apoptotic pathways, providing promising targets for anticancer therapies...
  24. ncbi Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5
    L R Thomas
    Cell Death Differ 13:160-2. 2006
  25. ncbi TRAIL-receptor expression is an independent prognostic factor for survival in patients with a primary glioblastoma multiforme
    Jos M A Kuijlen
    Department of Neurosurgery, University Hospital Groningen, Groningen, The Netherlands
    J Neurooncol 78:161-71. 2006
    ..The aim of this study was to quantify the expression of the death regulating receptors TRAIL-R1, TRAIL-R2 and TRAIL on primary GBM specimens and to correlate this expression with survival...
  26. pmc Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20092, USA
    Proc Natl Acad Sci U S A 103:7000-5. 2006
    ..LT from HIV(prog) exhibited higher TRAIL and DR5 mRNA levels than LT from HIV(NP) or controls. TRAIL mRNA levels in LT correlated with plasma viral load...
  27. pmc Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
    Delphine Merino
    INSERM, U517, Univ Bourgogne, Dijon F 21000, France
    Mol Cell Biol 26:7046-55. 2006
    ..apoptosis is mediated by the transmembrane receptors death receptor 4 (DR4) (also known as TRAIL-R1) and DR5 (TRAIL-R2)...
  28. ncbi Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system
    Haizhen Zhu
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Gastroenterology 133:1649-59. 2007
    ..However, the interaction between HCV and hepatocyte innate antiviral defense systems is not understood. The aim of this study was to examine how human hepatocytes respond to HCV infection...
  29. pmc Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells
    Stavroula Baritaki
    Department of Microbiology, Immunology, and Molecular Genetics, Division of Surgical Oncology, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 180:6199-210. 2008
    ..Proteasome inhibitors potentiate TRAIL apoptosis in vitro and in vivo and correlate with up-regulation of death receptor 5 (DR5) via an unknown mechanism...
  30. doi Hydrogen peroxide enhances TRAIL-induced cell death through up-regulation of DR5 in human astrocytic cells
    Daeho Kwon
    Medical Research Center for Environmental Toxico Genomics and Proteomics, Korea University College of Medicine, Anam dong 5ga 126 1, Seongbuk gu, Seoul 136 705, Republic of Korea
    Biochem Biophys Res Commun 372:870-4. 2008
    ..responsible for H(2)O(2)-induced sensitization, we examined expression of various genes (Caspase-8, Fas, FasL, DR4, DR5, DcR1, DcR2, TRAIL, TNFRp55) related to TRAIL-induced cell death...
  31. doi TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5
    Yaqin Zhang
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Mol Cancer Res 6:1861-71. 2008
    ..evaluated clinically as anticancer therapies, selectively kill cancer cells through the death receptors DR4 and DR5. However, their therapeutic potential is limited by occurring resistance in tumor cells...
  32. doi Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
    Zhaoyu Jin
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cell 137:721-35. 2009
    Cell-surface death receptors such as DR4 and DR5 trigger apoptosis through a death-inducing signaling complex (DISC) that recruits the apical protease caspase-8...
  33. doi TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors
    Eftychia Oikonomou
    Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Int J Cancer 125:2127-35. 2009
    ..Higher expression of its pro-death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5) attenuates higher sensitivity to TRAIL-induced apoptosis, and represents a marker for better cancer prognosis and ..
  34. pmc A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
    Amith Panner
    Brain Tumor Research Center, Department of Neurological Surgery and University of California San Francisco Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158 9001, USA
    Cancer Res 69:7911-6. 2009
    ..These results define the PTEN-Akt-AIP4 pathway as a key regulator of FLIP(S) ubiquitination, FLIP(S) stability, and TRAIL sensitivity and also define a novel link between PTEN and the ubiquitin-mediated control of protein stability...
  35. doi Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity
    Valeria Pavet
    Department of Cancer Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, BP 10142, Illkirch, France
    Cancer Res 70:1101-10. 2010
    ..are exploring anticancer approaches based on signaling by TRAIL, a ligand for the cell death receptors DR4 and DR5. In this study, we report on the selective apoptotic effects of multivalent DR5 binding peptides (TRAIL(mim/DR5)) ..
  36. doi Occurrence and regional distribution of TRAIL and DR5 on temporomandibular joint discs: comparison of disc derangement with and without reduction
    Rosalia Leonardi
    Department of Dentistry, University of Catania, Faculty of Dentistry, Policlinico Universitario, Catania, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:244-51. 2010
    ..It has been suggested to be a major contributing factor to tissue degeneration...
  37. pmc Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations
    Prashant Bavi
    Department of Human Cancer Genomic Research, MBC 98 16, Research Centre at KFNCCC, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia
    Mol Cancer 9:203. 2010
    ..apoptosis upon binding to its death domain containing receptors, TRAIL receptor 1 (DR4) and TRAIL receptor 2 (DR5)...
  38. pmc Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact
    Heath A Elrod
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, United States of America
    PLoS ONE 5:e12178. 2010
    b>Death receptor 5 (DR5) and caspase-8 are major components in the extrinsic apoptotic pathway...
  39. pmc Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Xiaobing Tian
    Department of Radiation Oncology and the Radiation Biology and Imaging Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:29408-16. 2011
    ..We found that Nelfinavir treatment led to ER stress-induced up-regulation of the DR5 receptor...
  40. doi Redistribution of DR4 and DR5 in lipid rafts accounts for the sensitivity to TRAIL in NSCLC cells
    Wen Ouyang
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, 169 Donghu Road, Wuchang District, Wuhan 430071, P R China
    Int J Oncol 39:1577-86. 2011
    ..compared to TRAIL-sensitive H460 cell line, TRAIL-resistant A549 cell line showed a similar expression level of DR5 and a higer expression level of DR4...
  41. pmc Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells
    Guangbo Liu
    School of Life Sciences, Shandong University, Jinan, China
    J Cell Mol Med 16:1618-28. 2012
    ..In this study, we show that salermide up-regulates the expression of death receptor 5 (DR5) in human non-small cell lung cancer (NSCLC) cells...
  42. pmc Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling
    You Take Oh
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA
    J Biol Chem 287:257-67. 2012
    ..b>Death receptor 5 (DR5) is a cell surface pro-apoptotic death receptor for tumor necrosis factor-related apoptosis-inducing ..
  43. pmc Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression
    Chunmei Wang
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Department of Surgery, Changzheng Hospital, Shanghai 200433, China
    J Biol Chem 284:16183-90. 2009
    ..Furthermore, Notch1 signaling could enhance DR5 expression in a p53-dependent manner...
  44. ncbi Rare loss-of-function mutation of a death receptor gene in head and neck cancer
    S I Pai
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University, Baltimore, Maryland 21205 2196, USA
    Cancer Res 58:3513-8. 1998
    ..Recently, a novel tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor gene, KILLER/DR5, a member of the tumor necrosis factor receptor family, was identified as a potential mediator in p53-..
  45. ncbi Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas
    T Arai
    Department of First Surgery, Tokyo Medical and Dental University School of Medicine, Japan
    Cancer Lett 133:197-204. 1998
    The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers...
  46. ncbi Mutation of the DR5/TRAIL receptor 2 gene is infrequent in hepatocellular carcinoma
    Yung Ming Jeng
    Department of Pathology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan
    Cancer Lett 181:205-8. 2002
    ..Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2/DR5), a member of tumor necrosis factor receptor family, is mapped to chromosome 8p21-22...
  47. pmc CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA
    Blood 106:3524-31. 2005
    ..The present study investigates the expression of TRAIL death receptor 5 (DR5) in the peripheral-blood mononuclear cells (PBMCs) of HIV-1-infected patients and its role in CD4(+) T-..
  48. pmc Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13974-9. 2005
    ..Our findings suggest a potential unique role of pDCs in the immunopathogenesis of HIV-1 infection by inducing the death molecule TRAIL...
  49. pmc Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor
    Almer M van der Sloot
    Department of Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Proc Natl Acad Sci U S A 103:8634-9. 2006
    ..drug that selectively induces apoptosis in a variety of cancer cells by interacting with death receptors DR4 and DR5. TRAIL can also bind to decoy receptors (DcR1, DcR2, and osteoprotegerin receptor) that cannot induce apoptosis...
  50. doi The role of TRAIL death receptors in the treatment of hematological malignancies
    Elizabeth S Henson
    Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, MB, Canada
    Leuk Lymphoma 49:27-35. 2008
    ..TRAIL induces apoptosis by binding to its two death receptors DR4 (TRAIL-R1) and DR5 (TRAIL-R2)...
  51. pmc CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation
    An Chi Tsai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    J Biol Chem 285:5497-506. 2010
    ..Such sensitization was achieved through up-regulation of death receptor 5 (DR5) but not DR4 or Fas...
  52. pmc ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1
    You Take Oh
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA
    J Biol Chem 285:41310-9. 2010
    b>Death receptor 5 (DR5) is a death domain-containing transmembrane receptor that triggers apoptosis upon binding to its ligand or when overexpressed...
  53. ncbi TRAIL receptor and CD95 signal to mitochondria via FADD, caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid
    Arlette B Werner
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 277:40760-7. 2002
    ..We conclude that the TRAIL receptor can bypass or neutralize the activity of cytosolic factor that blocks truncated Bid function. This may benefit the capacity of TRAIL to break apoptosis resistance in tumor cells...
  54. ncbi Peripheral blood and tumor infiltrating lymphocytes in non-small cell lung cancer: analysis at the population and clonal level
    M Viale
    Istituto Nazionale per la Ricerca sul Cancro, Laboratorio di Farmacologia, Genova, Italy
    Tumori 76:488-94. 1990
    ..receptor) and DR (MHC class II) antigens, which were increased in TILs, and in the percentage of CD16+ natural killer (NK) cells, which was reduced in TILs as compared to PBLs...
  55. ncbi Effects of biological response modifiers on lung natural killer activity
    W Lauzon
    Department of Pharmacology Faculty of Medicine, University of Ottawa, Ontario, Canada
    Immunopharmacol Immunotoxicol 13:237-50. 1991
    Natural killer (NK) activity plays an important role in host defense against tumors, especially once augmented by immunomodulators. It is likely that the modulation of NK cells is a reflection of the environment in which they reside...
  56. ncbi Effects of an acute bolus growth hormone infusion on the human immune system
    M Kappel
    Department of Infectious Diseases, Rigshospitalet, State University Hospital, Copenhagen, Denmark
    Horm Metab Res 25:579-85. 1993
    ..r-hGH did not influence the subpopulations of blood mononuclear cells (BMNC), natural killer cell activity, in vitro proliferative responses or production of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2,..
  57. ncbi Why do anal wounds heal adequately? A study of the local immunoinflammatory defense mechanisms
    Pedro Roberto de Paula
    Departamento de Medicina, Universidade de Taubate, Taubate, Brazil
    Dis Colon Rectum 47:1861-7. 2004
    ..The aim of this study was to identify the tissue defense immunoinflammatory mechanisms present in the healing process of anal region wounds resulting from hemorrhoidectomy by the open technique...
  58. ncbi Immune responses in the central nervous system
    D E Griffin
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Toxicol Pathol 15:294-302. 1987
    ..CNS involve the participation of most immunologically important cells: T and B lymphocytes, monocytes, and natural killer cells...
  59. ncbi Sex differentials in health and mortality
    L M Verbrugge
    Institute of Gerontology, University of Michigan, Ann Arbor 48109
    Women Health 12:103-45. 1987
    ..Yet, men have higher prevalence for many "killer" chronic conditions, higher prevalence rates of heart disease at younger ages, and higher injury rates at all ages...
  60. ncbi Phase II trial of outpatient interleukin-2 in malignant lymphoma, chronic lymphocytic leukemia, and selected solid tumors
    M A Allison
    Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246
    J Clin Oncol 7:75-80. 1989
    High-dose interleukin-2 (IL-2) with or without lymphokine-activated killer (LAK) cells has been reported to have activity in certain solid tumors, but toxicity has usually required hospitalization for administration...
  61. ncbi Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl
    G P Casale
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha 68198-6025
    Immunopharmacol Immunotoxicol 15:199-215. 1993
    ..inhibition of IL2 driven 1) proliferation of mouse CTLL2 cells, 2) proliferation of human natural killer (NK) cells, and 3) enhancement of target cell killing by human NK cells...
  62. pmc The effects of beta-adrenoceptor stimulation on adhesion of human natural killer cells to cultured endothelium
    R J Benschop
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Br J Pharmacol 113:1311-6. 1994
    1. The circulation of natural killer (NK) cells in vivo is influenced by physical exercise, mental stress, and infusion of beta-adrenoceptor agonists...
  63. ncbi Histamine and cytokine therapy
    K Hellstrand
    Department of Virology, , Sweden
    Acta Oncol 37:347-53. 1998
    Interleukin-2 (IL-2) and interferon-alpha (IFN-alpha) are potent activators of natural killer (NK) cells and other anti-tumor effector cells, but the results obtained in clinical trials with these cytokines have proved disappointing in ..
  64. ncbi Cloning and expression of a cDNA copy of the viral K28 killer toxin gene in yeast
    M J Schmitt
    , , Germany
    Mol Gen Genet 246:236-46. 1995
    The killer toxin K28, secreted by certain killer strains of the yeast Saccharomyces cerevisiae is genetically encoded by a 1...
  65. ncbi Yeast communities in a natural tequila fermentation
    M A Lachance
    Department of Plant Sciences, University of Western Ontario, London, Canada
    Antonie Van Leeuwenhoek 68:151-60. 1995
    ..Interactions involving killer toxins had no apparent direct effects on the yeast community structure.
  66. ncbi Characterization of the pulmonary lesions induced in rats by human recombinant interleukin-2
    J Zhang
    Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1518, USA
    Toxicol Pathol 23:653-66. 1995
    ..in capillaries and venules, marked interstitial infiltration by cytotoxic T lymphocytes, lymphokine-activated killer (LAK) cells, macrophages, and dendritic cells (as demonstrated by cell counting in preparations stained ..
  67. ncbi Immunotoxicity of polyunsaturated fatty acids in serum-free medium
    B U Tezabwala
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas 75235, USA
    Immunopharmacol Immunotoxicol 17:365-83. 1995
    ..Both human and murine cells were stimulated with recombinant human interleukin-2 to generate lymphokine activated killer cells...
  68. ncbi Genetic analysis of maintenance and expression of L and M double-stranded RNAs from yeast killer virus K28
    M J Schmitt
    , , Germany
    Yeast 8:373-84. 1992
    The killer phenotype expressed by Saccharomyces cerevisiae strain 28 differs from that of the more extensively studied K1 and K2 killers with respect to immunity, mode of toxin action and cell wall primary toxin receptor...
  69. ncbi Interleukin 1 and interferon-gamma: cytokines that provide reciprocal regulation of macrophage and T cell function
    R M Schultz
    Department of Immunology Research, Lilly Research Laboratories, Indianapolis, Indiana 46285
    Toxicol Pathol 15:333-7. 1987
    ..and replication of several subsets of precursor lymphocytes, including cytotoxic T cells, lymphokine-activated killer (LAK) cells, and natural killer (NK) cells, and enhances their cytotoxic activity for tumor cells...
  70. ncbi Inhibition of natural killer activity by calcitonin gene-related peptide
    Y Umeda
    Department of Chemotherapy and Biochemistry, Nippon Roche Research Center, Kamakura, Japan
    Immunopharmacol Immunotoxicol 11:309-20. 1989
    The effect of calcitonin gene-related peptide (CGRP) on natural killer (NK) cell activity in spleen cells from Balb/c mice and nude mice was studied...
  71. ncbi Effects of bromocriptine treatment on immune responses and 3-methylcholanthrene-induced tumorigenesis in rats
    J L Bussiere
    Department of Microbiology and Immunology, School of Medicine, Temple University, Philadelphia, PA 19140
    Immunopharmacol Immunotoxicol 13:47-64. 1991
    ..Tumor incidence was markedly increased and latency decreased in BCR-3MC rats compared to 3MC controls. Natural killer (NK) cell cytotoxicity responses and production of interleukin 2 (IL2) was enhanced at two weeks in rats treated ..
  72. ncbi Stress influence on development of hepatocellular tumors in transgenic mice overexpressing TGF alpha
    L Hilakivi-Clarke
    Lombardi Cancer Center, Georgetown University Medical School, Washington, D.C. 20007, USA
    Acta Oncol 34:907-12. 1995
    ..Natural killer (NK) cell activity, reduced in these mice, was not affected by housing environment...
  73. ncbi Natural killer activity in Fischer-344 rat lungs as a method to assess pulmonary immunocompetence: immunosuppression by phosgene inhalation
    G R Burleson
    Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711
    Immunopharmacol Immunotoxicol 11:421-43. 1989
    ..Studies were initiated (a) to evaluate the measurement of pulmonary natural killer (NK) activity as a method to assess pulmonary immunocompetence, and (b) to determine whether exposure to phosgene ..
  74. ncbi Killer-toxin-resistant kre12 mutants of Saccharomyces cerevisiae: genetic and biochemical evidence for a secondary K1 membrane receptor
    M J Schmitt
    , , D-55099 Mainz, Germany
    Arch Microbiol 164:435-43. 1995
    The Saccharomyces cerevisiae killer toxin K1 is a secreted alpha/beta-heterodimeric protein toxin that kills sensitive yeast cells in a receptor-mediated two-stage process...
  75. pmc Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis
    G Oberhuber
    Department of Clinical Pathology, University of Vienna Medical School, Austria
    Am J Pathol 148:1351-7. 1996
    ..The expression of TIA-1, GrB, CD3 (T-cell-receptor-associated complex), and Leu-7 (subset of natural killer cells) was studied by a sensitive three-step immunoperoxidase technique...
  76. ncbi Immunophenotypes and cytotoxic functions of lymphocytes in patients with hepatocellular carcinoma
    S S Chavan
    Cellular Immunology Unit, Tata Memorial Centre, Parel, Bombay, India
    Tumori 83:762-7. 1997
    ..In the tumor tissues, a significantly higher frequency of cytotoxic T cells compared to natural killer cells was observed...
  77. ncbi The effect of continuous corticosterone administration on lymphocyte subpopulations in the peripheral blood of the Fischer 344 rat as determined by two color flow cytometric analyses
    D K Flaherty
    Environmental Health Laboratory, Monsanto Agricultural Company, St. Louis, MO 63110
    Immunopharmacol Immunotoxicol 15:583-604. 1993
    ..Only numbers of natural killer cells were within normal limits...
  78. ncbi The immunosenescent phenotype in mice and humans can be defined by alterations in the natural immunity reversal by immunomodulation with oral AM3
    V G Villarrubia
    Dpt. of Clinical Research and Development, Immunology, I.F. Cantabria, Madrid, Spain
    Immunopharmacol Immunotoxicol 19:53-74. 1997
    The reactivities of monocyte/macrophages and natural killer (NK) cells (natural immunity) were evaluated following the administration of the biological response modifier AM3...
  79. ncbi Leukocyte Interleukin, Inj. (LI) augmentation of natural killer cells and cytolytic T-lymphocytes
    M A Chirigos
    CEL-SCI Corporation, Alexandria, VA 22314, USA
    Immunopharmacol Immunotoxicol 17:247-64. 1995
    ..To determine whether these responses elicited by LI were IL-2 driven, augmentation of natural killer cells (NKC) and cytolytic T cells (CTL), was tested both in vitro and in vivo. A single intraperitoneal (i.p...
  80. ncbi Cell cycle studies on the mode of action of yeast K28 killer toxin
    M J Schmitt
    , , Germany
    Microbiology 142:2655-62. 1996
    The virally encoded K28 killer toxin of Saccharomyces cerevisiae kills sensitive cells by a receptor-mediated process...
  81. ncbi Investigation of a killer strain of Zygosaccharomyces bailii
    F Radler
    , , Mainz, Germany
    J Gen Microbiol 139:495-500. 1993
    The yeast Zygosaccharomyces bailii strain 412 was found to liberate a killer toxin (KT412) lethal to sensitive strains of Saccharomyces cerevisiae and Candida glabrata...
  82. ncbi Halothane anesthesia decreases human monocyte hydrogen peroxide generation. Protection of monocytes by activation with gamma interferon
    G W Stevenson
    Department of Anesthesia, Childrens Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614
    Immunopharmacol Immunotoxicol 9:489-510. 1987
    ..Natural killer cell activity against K-562 was unaffected by halothane in most of the donors tested...
  83. ncbi Linear DNA plasmids from Pichia etchellsii, Debaryomyces hansenii and Wingea robertsiae
    Y S Cong
    Institut Curie, Section de Biologie, Centre Universitaire Paris XI, Orsay, France
    Microbiology 140:1327-35. 1994
    ..The plasmids of K. lactis strains were associated with a killer activity and their structure was similar to the known killer plasmids pGKL1 and 2...
  84. ncbi Comparison of immune functional parameters following in vitro exposure to natural and synthetic amphetamines
    R V House
    IIT Research Institute, Chicago, IL 60616
    Immunopharmacol Immunotoxicol 16:1-21. 1994
    ..was measured by proliferation, and natural immunity was assessed by quantitating basal and IL-2 augmented natural killer (NK) cell activity. None of the compounds tested had any direct effect on cellular viability...
  85. ncbi The novel acidophilic structure of the killer toxin from halotolerant yeast demonstrates remarkable folding similarity with a fungal killer toxin
    T Kashiwagi
    Protein Engineering Research Institute [Biomolecular Engineering Research Institute (BERI) as of the 1st of April 1996, Furuedai, Suita, Osaka 565, Japan
    Structure 5:81-94. 1997
    BACKGROUND: Several strains of yeasts and fungi produce proteinous substances, termed killer toxins, which kill sensitive strains...
  86. pmc The Mof2/Sui1 protein is a general monitor of translational accuracy
    Y Cui
    Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, UMDNJ, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 18:1506-16. 1998
    ..The yeast Saccharomyces cerevisiae killer virus system uses programmed -1 ribosomal frameshifting to synthesize its gene products...
  87. ncbi Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine: I. Activation of natural killer cells in mice
    B S Sharma
    Department of Immunology, ICN Pharmaceuticals, Costa Mesa, CA 92626
    Immunopharmacol Immunotoxicol 14:1-19. 1992
    ..Since certain tumor metastases and virus infected cells are targets to natural killer cells (NK cells), we now investigated whether 7T8OG is capable of activating NK cells in mice using NK cell ..
  88. ncbi Isolation and sequence analysis of a gene from the linear DNA plasmid pPacl-2 of Pichia acaciae that shows similarity to a killer toxin gene of Kluyveromyces lactis
    P L Bolen
    National Center for Agricultural Utilization Research, US Department of Agriculture, Peoria, IL 61604
    Yeast 10:403-14. 1994
    ..The sequence has been deposited in the GenBank data library under Accession Number U02596...
  89. ncbi Absence of cell wall chitin in Saccharomyces cerevisiae leads to resistance to Kluyveromyces lactis killer toxin
    M A Takita
    Department of Biochemistry, , Brazil
    Yeast 9:589-98. 1993
    Kluyveromyces lactis killer toxin causes sensitive strains of a variety of yeasts to arrest at the G1 stage of the cell cycle, and to lose viability...
  90. ncbi Autoimmune thyroiditis following interleukin-2 and LAK cell therapy for metastatic renal cell carcinoma: correlation with tumor regression
    C Besana
    Divisione di Medicina II, Istituto Scientifico San Raffaele, , Italy
    Tumori 77:339-42. 1991
    A 63-year-old woman receiving recombinant interleukin-2 (rIL-2) + lymphokine activated killer cells for metastatic renal cell carcinoma developed autoimmune thyroiditis with clinical hypothyroidism and high titer anti-thyroglobulin and ..
  91. ncbi Immunotherapy with low-dose subcutaneous interleukin-2 plus beta-interferon as a second-line therapy for metastatic colorectal carcinoma
    S Barni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 79:343-6. 1993
    ..Toxicity was low in all cases. Natural killer cell and T-activated lymphocyte mean number significantly increased during the immunotherapy...
  92. pmc Isolation of Candida glabrata homologs of the Saccharomyces cerevisiae KRE9 and KNH1 genes and their involvement in cell wall beta-1,6-glucan synthesis
    S Nagahashi
    Department of Biology, McGill University, , Quebec, Canada H3A 1B1
    J Bacteriol 180:5020-9. 1998
    ..Although a cgknh1Delta mutant showed no phenotype beyond slightly increased sensitivity to the K1 killer toxin, disruption of CgKRE9 resulted in several phenotypes similar to those of the S...
  93. ncbi A nuclear gene required for the expression of the linear DNA-associated killer system in the yeast Kluyveromyces lactis
    M Wesolowski-Louvel
    Institut Curie, Section de Biologie, Centre Universitaire, Orsay, France
    Yeast 4:71-81. 1988
    The killer system of Kluyveromyces lactis is associated with two linear DNA plasmids, pGKL1 and pGKL2. The killer toxin and the immunity determinant are coded for by pGKL1...
  94. ncbi KEX2 influences Candida albicans proteinase secretion and hyphal formation
    G Newport
    Department of Stomatology, University of California at San Francisco, San Francisco, California 94143-0422, USA
    J Biol Chem 272:28954-61. 1997
    ..Positive clones were assayed for killer toxin activity, another Kex2-dependent phenotype...
  95. ncbi Killer behaviour in wild wine yeasts associated with Merlot and Malbec type musts spontaneously fermented from northwestern Patagonia (Argentina)
    M P Sangorrín
    Laboratorio de Microbiología y Biotecnología, Departamento de Quimica, Facultad de Ingenieria, Universidad Nacional del Comahue, Buenos Aires 1400 8300 Neuquén, Argentina
    J Basic Microbiol 41:105-113. 2001
    The occurrence of killer wine yeasts in Comahue Region (Patagonia, Argentina) was studied. Wild wine yeasts were isolated from spontaneously fermenting Merlot and Malbec type musts...
  96. ncbi Induction of immune rejection of tumors by protein A in mice bearing transplantable solid tissue Dalton's lymphoma tumors
    P D Dwivedi
    Immunobiology Division, Industrial Toxicology Research Centre, Lucknow, India
    Immunopharmacol Immunotoxicol 14:105-28. 1992
    ..Apart from the nonspecific immunopotentiation, Protein A also activates natural Killer (NK) cell activity and also splenic lymphocytes mediated killing of autologous tumor targets in a significant (p ..
  97. ncbi Reduced NK activity in pulmonary tuberculosis patients with/without HIV infection: identifying the defective stage and studying the effect of interleukins on NK activity
    R Nirmala
    Tuberculosis Research Centre, Mayor V.R. Ramanathan Road, Chetput, Chennai, 600 031, India
    Tuberculosis (Edinb) 81:343-52. 2001
    ..to understand the non-major histocompatibility restricted cytotoxicity in order to delineate the role of natural killer (NK) cells towards the development of host immunity to tuberculosis...
  98. ncbi Promoter activity associated with the left inverted terminal repeat of the killer plasmid k1 from yeast
    X J Chen
    Institut Curie, Section de Biologie, Orsay, France
    Biochimie 73:1195-203. 1991
    The killer plasmid k1 of Kluyveromyces lactis has terminal inverted repeats of 202 base pairs (bp). The left terminal repeat is contiguous to the transcribed open reading frame, ORF1, which is supposed to code for a DNA polymerase...
  99. ncbi High-level secretion of correctly processed recombinant human interleukin-1 beta in Kluyveromyces lactis
    R Fleer
    , Biotechnology, Department, Vitry, France
    Gene 107:285-95. 1991
    ..lactis killer toxin...
  100. ncbi A new procedure for large scale production and freezing of lymphokine activated killer (LAK) cells to be used in adoptive immunotherapy of cancer
    C Gambacorti-Passerini
    Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan, Italia
    Tumori 74:523-30. 1988
    ..With this procedure therefore large quantities of lymphokine activated killer cells (LAK) can be easily produced to be used in adoptive immunotherapy trials.
  101. ncbi Fusarium proliferatum culture material alters several production and immune performance parameters in White Leghorn chickens
    M A Qureshi
    Department of Poultry Science, North Carolina State University, Raleigh 27695-7608, USA
    Immunopharmacol Immunotoxicol 17:791-804. 1995
    ..Macrophages from treated chicks exhibited a 34% reduction in phagocytic activity. Natural killer cell activity was not affected...

Research Grants102 found, 100 shown here

  1. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..pathogens and consists of numerous soluble factors and cell types, including dendritic cells (DC) and natural killer cells...
  2. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..barrier and induces a migration of different cell type such as neutrophils, macropages, T lymphocytes and natural killer cells through the airway epithelium...
  3. DEVELOPMENT AND FUNCTION OF INTESTINAL LYMPHOID TISSUES
    Rodney D Newberry; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: During intestinal inflammation a unique population of natural killer cells are generated...
  4. Understanding the role of IL-10 in acute murine cytomegalovirus infection
    Pamela J Gaddi; Fiscal Year: 2010
    ..we will evaluate the effects of IL-10 on the cytokine production, cytotoxicity, and proliferation of (1) natural killer cells, which are critical early antiviral responders and (2) CD8 T cells, which respond at 5-7 days post infection ..
  5. Biochemical Characterization of the Regulatory T-cell Protein LAG-3.
    Zarixia Zavala Ruiz; Fiscal Year: 2010
    ..This protein is expressed in activated natural killer cells, CD4+ and CD8+ T-cells. B-cells also express LAG-3 in a T-cell dependent manner...
  6. Patricia E Molina; Fiscal Year: 2014
    ..receptor subtypes (CB1 and CB2) as well as their localization (CB2predominantly on B lymphocytes and natural killer cells) has resulted in identification of multisystemic biomedical effects...
  7. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cytotoxic T lymphocytes and natural killer cells release granzymes and perforin from cytotoxic granules into the immune synapse to induce apoptosis of virally infected or tumor targets...
  8. Joyce C Solheim; Fiscal Year: 2014
    ..Flt3L preferentially expands DC1 cells and increases the type 1 T cell response and the numbers of natural killer cells, and it has been shown to have an immunologically mediated anti-tumor effect in several cancer models...
  9. Mitchell Kronenberg; Fiscal Year: 2015
    ..responses are impaired in Hvem-/- mice, including decreased IL-22 production by specialized intestinal natural killer cells (NK22 cells) and decreased generation of IL-17 secreting T lymphocytes (Th17 cells)...
  10. Molecular Mechanisms of HIV Disease Pathogenesis
    Kathleen L Collins; Fiscal Year: 2013
    ..antiviral factor that inactivates the virus by converting cytosine residues to uracils, also alerts natural killer cells to the infection. HIV counteracts this cellular response via the concerted activities of Vif, Vpr and Nef...
  11. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..of the host immune response, including T and B cells, macrophages, dendritic cells, PMNs, mast cells, and natural killer cells...
  12. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..Decidual natural killer cells (50-90% of leukocytes in the decidua that were characterized during the first 5 years of this project) ..
  13. Predictors of Immunologic Long-term Non-Progression in Children with HIV
    Jintanat Ananworanich; Fiscal Year: 2010
    This proposed study will evaluate the activation and other surface markers of T and B lymphocytes, natural killer cells and monocytes in children who are enrolled in the PREDICT Study (CIPRA 1U19AI53741-01A1, An open label, randomized ..
  14. Jack L Strominger; Fiscal Year: 2014
    ..Decidual natural killer cells (~70% of leukocytes in the decidua that were characterized during the first 5 years of this project) ..
  15. PETER R PARHAM; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Natural killer (NK) cells are lymphocytes distinct from B and T cells that have essential roles in innate immunity and placental reproduction...
  16. Material Fumonisin Exposure and Pregnancy Outcome: Decoding the Sphingolipid Immu
    Janee Gelineau van Waes; Fiscal Year: 2009
    ..in immune surveillance and the presentation of lipid antigens to the invariant 12 T-cell receptor on natural killer T-cells (NKT)...
  17. T Cell Modulation by NKG2D
    Thomas Spies; Fiscal Year: 2013
    The NKG2D receptor triggers natural killer cells and costimulates T cells upon engagement of ligands that are absent from most normal cells but can be induced by cell stress...
  18. Cetuximab Therapy of Pancreatic Cancer: Immune Modulation with IL-21
    William E Carson; Fiscal Year: 2010
    ..activating cytokines can enhance the anti-tumor activity of mAbs via their ability to stimulate potent natural killer (NK) cell and monocyte cytotoxicity and cytokine secretion...
  19. NK Cell Control of Acute Influenza Virus Infection
    Jonathan W Heusel; Fiscal Year: 2010
    ..Natural killer (NK) cells are cytotoxic lymphocytes that respond in the earliest phase of viral infections to control viral ..
  20. KELLY M STOREK; Fiscal Year: 2015
    ..including antigen presentation and production of cytokines involved in activation of T cells, B cells and natural killer cells...
  21. Psychogenetic Factors in Project REACH
    Nicole R Nugent; Fiscal Year: 2013
    ..g., CD4/CD8 lymphocytes, HIV-1 plasma RNA levels, cytokines, and natural killer cells) in youth living with HIV (YLH)...
  22. Anthony R French; Fiscal Year: 2016
    Natural killer (NK) cells are innate lymphocytes that play a pivotal role in early anti-pathogen host defense and are particularly important in mediating resistance to viral infections...
  23. Effects of chronic alcohol consumption on pathogenesis of respiratory viral infec
    THOMAS JERRELLS; Fiscal Year: 2009
    ..limit early control of viral infection by suppressing activation of natural killer cells, which limits production of interferon (IFN)-. B...
  24. Adoptive Immunotherapy of Cancer with IL-12 Secreting Tumor-Targeted T cells
    RENIER JOSEPH BRENTJENS; Fiscal Year: 2013
    ..IL-12 secretion by targeted T cells will recruit or activate other host immune elements, including natural killer cells as well as anergic TILs, thereby broadening the anti-tumor immune repertoire...
  25. MEGAN ANNE COOPER; Fiscal Year: 2014
    ..e., they do not exhibit memory of prior activation. Natural killer (NK) cells are innate lymphocytes capable of recognizing and killing target cells and producing immunoregulatory ..
  26. Marco Colonna; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Natural killer cells are generally viewed as a first line of defense in cancer immunosurveillance and are critical players in immune-mediated cancer rejection...
  27. Immunobiology of NKT cell development and function
    DEREK B SANT apos ANGELO; Fiscal Year: 2010
    Invariant Natural Killer T cells (iNKT cells) are a rare but potent population of cells expressing features in common with both natural killer cells and T cells...
  28. Wayne M Yokoyama; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The overall goal of this proposal is to better understand how natural killer (NK) cells are tolerant to self in order to gain insight into how NK cells control tumors and infections...
  29. Soma Jyonouchi; Fiscal Year: 2015
    ..Host defense against viral infection and malignancy requires natural killer (NK) cells, which can innately recognize and kill affected cells...
  30. CANCER THERAPY WITH ACTIVATED NATURAL KILLER CELLS
    Ronald Herberman; Fiscal Year: 2000
    There has been increasing evidence for an important role of natural killer (NK) cells in resistance against cancer and particularly inhibition of the development of metastases...
  31. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..processes including angiogenesis, lymphocyte trafficking and the migration of hematopoietic stem cells, natural killer cells, and cancer cells...
  32. ACTIVATION OF XENOGENEIC ENDOTHELIUM TO RESIST INJURY
    Agustin P Dalmasso; Fiscal Year: 2010
    ..protective molecules will be studied in protection from apoptosis elicited with TNF-alpha and with human natural killer cells...
  33. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..Human NK cell functions in immunity and reproduction are controlled by highly polymorphic interactions between killer cell immunoglobulin-like receptors (KIR) and major histocompatibility complex (MHC) I ligands...
  34. Protective immunity against HIV: the role of IgG subclass and glycosylation
    Donald Forthal; Fiscal Year: 2009
    Project Summary Engagement of IgG Fc receptors (Fc?Rs) on natural killer cells, monocytes, macrophages, or dendritic cells may play a critical role in preventing lentivirus infection...
  35. Protein Carbohydrate Interactions in Cell Communication
    James C Paulson; Fiscal Year: 2010
    ..immunity, including C-type lectins, siglecs and the CD1 T-cell receptor in dendritic cells, macrophages, natural killer cells and other leukocytes, are being explored, as are aspects of cell signaling mediated by galectins, siglecs ..
  36. Mapping the functional major histocompatibility complex genes in zebrafish
    JILL L DE JONG; Fiscal Year: 2012
    ..In addition, immunology experiments studying antigen presentation, activation of lymphocytes and natural killer cells, and infectious disease models in the zebrafish would become possible...
  37. Role of fascin1 in dendritic cell-mediated immunity against listeria infection
    Shigeko Yamashiro; Fiscal Year: 2013
    ..Fascin1 is absent in immature DCs or in other blood cells including macrophages, neutrophils and natural killer cells, suggesting a specific role for fascin1 in DC biology upon maturation...
  38. Amy M Fulton; Fiscal Year: 2016
    ..Furthermore, that EP1 controls metastasis by a mechanism dependent on Natural Killer cells...
  39. AvanceIII 700MHz NMR spectrometer with cryogenic probe
    James J Chou; Fiscal Year: 2010
    ..regions of immunoreceptors, by solving the structure of an activating immune receptor complex from the Natural Killer cells, consisting of the transmembrane domains of the dimeric DAP12 signaling module and the NKG2C receptor chain...
  40. The Role of RNA Interference in West Nile Virus Diversification
    Douglas E Brackney; Fiscal Year: 2010
    ..Vertebrates respond to viral infections mainly via type-1 interferon and natural killer cells, whereas mosquitoes rely on RNA interference (RNAi) as an intracellular defense mechanism to control viral ..
  41. Elucidating mechanisms governing transcriptional regulation of the human LAT gene
    Timothy S Finco; Fiscal Year: 2013
    ..highly conserved among mammals, is critical for the development and/or function of T cells, mast cells, Natural Killer cells, and megakaryocytes/platelets...
  42. Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 (NK1-R) Antagonists
    STEVEN DANIEL DOUGLAS; Fiscal Year: 2013
    ..This NK1RA has activity as an antiviral HIV agent that improves innate immunity (Natural Killer cells) and has positive neurobehavioral effects. NK1RA are a potential novel therapy for neuroAIDS.
  43. Lester F Lau; Fiscal Year: 2016
    ..The senescent stellate cells express anti-fibrotic genes and are targeted for removal by natural killer cells, thereby limiting fibrosis and facilitating resolution of the healing response...
  44. WILLIAM JOSEPH MURPHY; Fiscal Year: 2015
    ..Natural killer (NK) cells represent critical components of the innate immune response and are being increasingly used as a ..
  45. NK Cells in GVHD and GVT
    Robert S Negrin; Fiscal Year: 2012
    ..In this proposal we will focus on natural killer (NK) cells which have known anti-tumor capabilities yet do not cause GVHD...
  46. 13th International Meeting of the Society for Natural Immunity April 20-24, 2012
    Lewis L Lanier; Fiscal Year: 2012
    ..underrepresented minorities to attend a four-day international scientific meeting devoted to the study of natural killer Cells (NK cells)...
  47. Jennifer A Maynard; Fiscal Year: 2014
    ..As a part of innate immunity, these processed peptides are presented on cell surfaces for recognition by Natural Killer cells to indicate that the cell is healthy...
  48. Generation of Ikaros conditional knockout mice
    SUSAN M WINANDY; Fiscal Year: 2012
    ..Defects in Ikaros null mice include a total lack of B and natural killer cells, selective lack of some lineages of dendritic and ?dT cells and defects in a[unreadable]T cell development...
  49. DEK and TNF inhibitors in juvenile arthritis
    DAVID MICHAEL MARKOVITZ; Fiscal Year: 2012
    ..cells and released by apoptotic T cells, and serve as a chemoattractant for neutrophils, CD8+ T cells, and natural killer cells...
  50. Elizabeth A Trachtenberg; Fiscal Year: 2014
    ..medically refractory UC). The contribution of the natural killer cells (NK) in innate immunity to the risk of IBD has not been as well examined...
  51. David A Spiegel; Fiscal Year: 2015
    ..antigens with high affinity and selectivity, and the ability to trigger the action of professional phagocytic and killer cells (e.g., natural killer cells, macrophages, and dendritic cells)...
  52. Koichi Yuki; Fiscal Year: 2016
    ..playing a role in leukocyte arrest on the endothelium, phagocytosis, immunological synapse formation, natural killer cells cytotoxicity, and so on...
  53. COBRE for Perinatal Biology
    James F Padbury; Fiscal Year: 2012
    ..stem cell repair of cardiac injury in adult life;5) the immunopathogenesis of preeclampsia;6) role of natural killer cells in successful pregnancy outcomes...
  54. Eugene C Butcher; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Tumorigenesis is controlled by mechanisms of immune surveillance. Natural killer cells are important mediators of innate anti-tumor immunity, and immunostimulatory dendritic cells and cytotoxic T ..
  55. ADJOA R SMALLS-MANTEY; Fiscal Year: 2015
    ..viral epitopes coating an infected CD4+ target T cell and an Fc receptor bearing effector, most commonly natural killer cells (NKs), bind the Ab and use perforin to deliver granzymes which induce apoptosis in the target...
  56. Innate Immunity and Cancer Therapy
    SARAH ANNE COOLEY; Fiscal Year: 2011
    ..and evidence suggests that at least part of the efficacy is mediated through the indirect activation of natural killer cells...
  57. Natural Killer Cell Receptor Diversity and CMV in Hematopoietic Cell Transplantat
    STEVEN AARON PERGAM; Fiscal Year: 2013
    ..This project will build on preliminary work evaluating the role of killer immunoglobulin-like receptors (KIR) in CMV infection in hematopoietic cell transplantation (HOT)...
  58. ACTIN AND MICROTUBULE-BASED MECHANISMS FOR FUNCTIONS OF NK LYMPHOID CELLS
    John A Cooper; Fiscal Year: 2013
    ..provided by applicant): To investigate how actin and microtubules function in vivo, we are using the Natural Killer (NK) lymphoid cell as a model cell system...
  59. Activation of Plasmacytoid Dendritic Cells (pDCs) to Induce Antitumor Activity
    Patrick Hwu; Fiscal Year: 2012
    ..viruses and lead directly to the activation of other immune cells, including myeloid dendritic cells and natural killer cells which then lead to a potent adaptive T-cell immune response...
  60. Synthetic immunoreceptor systems for combinatorial tumor antigen detection
    Chia Yung Wu; Fiscal Year: 2013
    ..2) Compare the properties of the developed CAR systems in both T cells and Natural Killer cells, two major types of immune cells that are therapeutically useful in adoptive immunotherapy...
  61. Wayne M Yokoyama; Fiscal Year: 2015
    ..Wayne Yokoyama at Washington University in St. Louis. As major components of the innate immune system, natural killer (NK) cells provide host defense against pathogens and developing tumors...
  62. Modulation of surface markers by HIV-1 Vpu/Vpr and sensitivity to NK cell lysis
    VICENTE contact PLANELLES; Fiscal Year: 2010
    ..We are referring to the virus'ability to avoid and suppress the immune response. Natural killer (NK) cells are an understudied arm of the immune response against HIV, but are recognized as being crucial in the ..
  63. RECEPTOR AGGREGATION AND ITS EFFECTS
    BYRON B GOLDSTEIN; Fiscal Year: 2012
    ..which, when co-crosslinked with FceRI, acts as an inhibitory receptor and FcyRllla, the receptor on Natural Killer cells that mediates antibody-dependent cell-mediated cytotoxicity...
  64. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..The causes of the more rapid emergence and spread of these "killer" viruses and pathogens are not entirely known, but are thought to be caused by some combination of deforestation ..
  65. James D Bryers; Fiscal Year: 2016
    ..cells - DCs) to produce T- and B-cell memory and antibody expression, and potentially stimulate direct native killer T-cell responses...
  66. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    Lung cancer is the number one cancer killer in the United States, exceeding breast, colorectal, prostate, and melanoma malignancies combined...
  67. Michael J Rosen; Fiscal Year: 2016
    ..by two co-mentors;Luc Van Kaer, PhD, an immunologist internationally recognized for his expertise in natural killer T cells, adaptive immunity, and mucosal immunology, and R. Stokes Peebles, Jr...
  68. ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLY
    Joyce Solheim; Fiscal Year: 2009
    ..In addition, the number of surface MHC class I molecules on target cells influences their recognition by natural killer cells...
  69. Neutralizing and non-neutralizing antibodies protection from breast milk HIV-1
    Manish Sagar; Fiscal Year: 2013
    ..On the other hand, immune effector cells, such as natural killer cells, may eliminate maternal breast milk cell free viruses and infected cells through antibody dependent cellular ..
  70. Blood Cell-Spheres: Growth, Description, and Potential
    AUDREY NADINE JAJOSKY; Fiscal Year: 2013
    ..to develop individualized (patient-specific) therapies that will use antibodies and/or immune cells ("natural killer cells," macrophages, cytotoxic T cells) to attack cancer-causing leukemia "stem" cells (LSC's) without ..
  71. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..Fnip1 null mice have blocks in pre-B cell and invariant natural killer T (iNKT) cell development at stages where the cells normally undergo massive division dependent on c- Myc, an ..
  72. Renal Cell Tumor-Mediated Trans-differentiation of Natural Killer Cells
    ANDREW CHRISTROPHER WILBER; Fiscal Year: 2013
    ..Natural killer (NK) cells have classically been associated with immune surveillance of tumors and are thought to destroy tumor ..
  73. Role of Natural Killer Cells in Myocarditis and Dilated Cardiomyopathy
    Sufey Ong; Fiscal Year: 2013
    ..Depletion of natural killer (NK) cells during of experimental autoimmune myocarditis (EAM) significantly increases levels of disease severity, ..
  74. PETER R PARHAM; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Controlling vital natural killer (NK) cell functions in immunity and reproduction are variable receptors that recognize polymorphic determinants of major histocompatibility complex (MHC) class I ..
  75. Robert L Ferris; Fiscal Year: 2014
    ..such as immune cell activation through antibody dependent cellular cytotoxicity (ADCC) mediated by natural killer (NK) cells and monocytes, through the constant fragment (Fc) domain of the mAb binding to polymorphic Fc? ..
  76. IL15 AND NATURAL KILLER (NK) CELL FUNCTION
    William Carson; Fiscal Year: 1999
    We hypothesize that macrophages are able to influence the function of natural killer (NK) cells via a novel cytokine known as IL-15...
  77. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..The causes of the more rapid emergence and spread of these "killer" viruses are not entirely known, but are thought to be caused by some combination of deforestation with ..
  78. Immune dysregulation by psychosocial distress
    HERBERT MATHEWS; Fiscal Year: 2006
    ..Psychosocial distress impairs the immune system, impacting both natural killer cells and the production of cytokines...
  79. The role of macrophages and natural killer cells in cisplatin-induced acute renal
    Lawrence Lu; Fiscal Year: 2007
    ..Thus the grant proposal will focus on IL-1a and IL-6. Macrophages and natural killer (NK) cells are known sources and targets of IL-1a and IL-G...
  80. Gilbert R Kinsey; Fiscal Year: 2014
    ..response to kidney injury through suppression of a specific innate pathway involving dendritic cells, natural killer T cells and neutrophils, and that pharmacological stimulation of A2A receptors will enhance innate Treg cell ..
  81. DANIELLE RENNER; Fiscal Year: 2014
    ..Previous work has shown that enhancement of anti-tumor killer T cell responses via dendritic cell vaccination correlates with a positive immune response in select GBM patients...
  82. Model System Studies of Naltrexone and Alcohol Interaction
    DIPAK SARKAR; Fiscal Year: 2009
    ..In particular, naltrexone enhances the effects of opioid ligands on natural killer cell functions. The underlying molecular basis for these observations is not known...
  83. PREGNANCY-SPECIFIC MODULATION OF NK CELLS
    Michael Soares; Fiscal Year: 2001
    ..of signals originating in trophoblast cells of the developing chorioallantoic placenta and targeted toward Natural Killer cells located within the uteroplacental compartment...
  84. LIVER NATURAL KILLER & ACCESSORY CELLS IN MURINE LUPUS
    Daniel Magilavy; Fiscal Year: 1992
    ..immune regulation have been reported including activation of Kupffer cells and high activity of hepatic natural killer cells...
  85. Chimeric IgG/A Tumor Immunotherapy
    KEITH WYCOFF; Fiscal Year: 2013
    ..FcRn binding; (b) purification using Protein A;and (c) augmented cellular recruitment and activation of natural killer (NK) cells via Fc? receptor binding...
  86. Natural killer cells and control of SIV infection
    R Paul Johnson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Innate immune responses, including natural killer (NK) cell responses, are the principal defense against viral infections prior to the development of adaptive immune responses and can play a critical ..
  87. Prevention of Diabetes with Lipid Immunomodulators
    Steven Porcelli; Fiscal Year: 2005
    In recent years, CD1d-restricted natural killer T cells (NK T cells) have been identified as a critical population of regulatory T cells that function to control autoimmune responses...
  88. Prevention of Diabetes with Lipid Immunomodulators
    Teresa Dilorenzo; Fiscal Year: 2005
    In recent years, CD1d-restricted natural killer T cells (NK T cells) have been identified as a critical population of regulatory T cells that function to control autoimmune responses...
  89. Role of Prdx 1 in Natural Killer Cells and Tumorigenesis
    Carola Neumann; Fiscal Year: 2007
    ..This proposal will help to understand the role of the antioxidant protein peroxiredoxin 1 (Prdx1) in natural killer cell function and tumor susceptibility...
  90. Effects of amino acids on regional lipid metabolism
    Elisabet Borsheim; Fiscal Year: 2013
    ..Coronary Heart Disease (CHD) is the single largest killer of American men and women...
  91. NATURAL KILLER CELLS IN THE LUNG
    Joan Stein Streilein; Fiscal Year: 1992
    DESCRIPTION: (Adapted from applicant's abstract): The natural killer lymphocyte (NK) is a cytotoxic cell that can lyse virus infected cells, or tumor cells without prior sensitization to the antigens expressed on those cells...
  92. Kaposi's Sarcoma-Associated Herpesvirus (KSHV) evasion of Natural Killer cells
    ALEXIS SPAIN MADRID; Fiscal Year: 2010
    ..thus potentially exposing these cells to Natural Killer (NK) cell mediated lysis. We hypothesized that KSHV has also evolved a mechanism to evade killing by NK cells...
  93. ANALYSIS OF KILLER CELL INHIBITORY RECEPTOR COMPLEX
    David Lawlor; Fiscal Year: 1999
    ..Abstract): The investigator proposes to characterize the genomic region of human chromosome 19 that contains the Killer Cell Inhibitory Receptor (KIR) genes...
  94. NOVEL CYTOKINE NATURAL KILLER CELL SIGNALING
    Michael Soares; Fiscal Year: 2001
    ..further our understanding of the interactions of a novel cytokine, prolactin-like protein- A (PLP-A ) and Natural Killer cells...
  95. FUNCTIONAL DEVELOPMENT OF NATURAL KILLER CELLS
    Amy Reichlin; Fiscal Year: 1999
    Natural killer (NK) cells provide host defense not only against tumors but also viral and intracellular infections including cytomegalovirus, T. gondii, and L. monocytogenes that are important pathogens in neonatal infections...
  96. ORGIN AND DIFFERENTIATION OF NATURAL KILLER CELLS
    Vinay Kumar; Fiscal Year: 2003
    Natural Killer (NK) cells have been implicated in defense against cancer, viral infection, and regulation of hemopoiesis...
  97. Hunting for Endogenous Ligands for Invariant Natural Killer T Cells
    Peng George Wang; Fiscal Year: 2010
    ..In contrast, a specialized subpopulation of T cells called invariant natural killer T (iNKT) cells recognizes glycolipid antigens presented by the MHC class I-like molecule, CD1d...
  98. Effects of Climate Change on Cholera Dynamics and Prediction
    Shafiqul Islam; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cholera has reemerged as a global killer with the world witnessing an unprecedented rise in cholera infection and transmission over the past two decades...
  99. NKT Cells Immunotherapy: Targeting Dendritic Cells with Glycolipid Liposomes
    Peng Wang; Fiscal Year: 2007
    ..drug delivery to dendritic cells for better harnessing the wide range of immunological functions of natural killer T cells...
  100. MECHANISMS OF ALLOGENEIC STEM CELL EDUCATION IN SCID
    Rebecca H Buckley; Fiscal Year: 2010
    ..characterize the phenotype and function by the development of normally functioning whether the decline in natural killer (NK) cell function in X-SCID and Jak3-deficient SCID is compensated for returning or new chimeras who are ..
  101. ANTIGEN IMMUNOSUPPRESSION BY KILLER LANGERHANS CELLS
    Akira Takashima; Fiscal Year: 2004
    ..We hypothesized that LC genetically modified to over-express CD95L (Fas ligand) termed "killer" LC, would deliver apoptotic signals to T cells upon antigen-specific interaction...